Relevant bibliographies by topics / Microfluidic Optical Stretcher

Academic literature on the topic 'Microfluidic Optical Stretcher'

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Published: 11 March 2023

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Journal articles on the topic "Microfluidic Optical Stretcher"

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Trotta, Gianluca, Rebeca Martínez Vázquez, Annalisa Volpe, Francesco Modica, Antonio Ancona, Irene Fassi, and Roberto Osellame. "Disposable Optical Stretcher Fabricated by Microinjection Moulding." Micromachines 9, no. 8 (August 4, 2018): 388. http://dx.doi.org/10.3390/mi9080388.

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Microinjection moulding combined with the use of removable inserts is one of the most promising manufacturing processes for microfluidic devices, such as lab-on-chip, that have the potential to revolutionize the healthcare and diagnosis systems. In this work, we have designed, fabricated and tested a compact and disposable plastic optical stretcher. To produce the mould inserts, two micro manufacturing technologies have been used. Micro electro discharge machining (µEDM) was used to reproduce the inverse of the capillary tube connection characterized by elevated aspect ratio. The high accuracy of femtosecond laser micromachining (FLM) was exploited to manufacture the insert with perfectly aligned microfluidic channels and fibre slots, facilitating the final composition of the optical manipulation device. The optical stretcher operation was tested using microbeads and red blood cells solutions. The prototype presented in this work demonstrates the feasibility of this approach, which should guarantee real mass production of ready-to-use lab-on-chip devices.
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Nava, Giovanni, Francesca Bragheri, Tie Yang, Paolo Minzioni, Roberto Osellame, Ilaria Cristiani, and Kirstine Berg-Sørensen. "All-silica microfluidic optical stretcher with acoustophoretic prefocusing." Microfluidics and Nanofluidics 19, no. 4 (June 16, 2015): 837–44. http://dx.doi.org/10.1007/s10404-015-1609-x.

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Yao, Zhanshi, Ching Chi Kwan, and Andrew W. Poon. "An optofluidic “tweeze-and-drag” cell stretcher in a microfluidic channel." Lab on a Chip 20, no. 3 (2020): 601–13. http://dx.doi.org/10.1039/c9lc01026b.

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Lautenschläger, Franziska, Stephan Paschke, Stefan Schinkinger, Arlette Bruel, Michael Beil, and Jochen Guck. "The regulatory role of cell mechanics for migration of differentiating myeloid cells." Proceedings of the National Academy of Sciences 106, no. 37 (August 26, 2009): 15696–701. http://dx.doi.org/10.1073/pnas.0811261106.

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Migration of cells is important for tissue maintenance, immune response, and often altered in disease. While biochemical aspects, including cell adhesion, have been studied in detail, much less is known about the role of the mechanical properties of cells. Previous measurement methods rely on contact with artificial surfaces, which can convolute the results. Here, we used a non-contact, microfluidic optical stretcher to study cell mechanics, isolated from other parameters, in the context of tissue infiltration by acute promyelocytic leukemia (APL) cells, which occurs during differentiation therapy with retinoic acid. Compliance measurements of APL cells reveal a significant softening during differentiation, with the mechanical properties of differentiated cells resembling those of normal neutrophils. To interfere with the migratory ability acquired with the softening, differentiated APL cells were exposed to paclitaxel, which stabilizes microtubules. This treatment does not alter compliance but reduces cell relaxation after cessation of mechanical stress six-fold, congruent with a significant reduction of motility. Our observations imply that the dynamical remodeling of cell shape required for tissue infiltration can be frustrated by stiffening the microtubular system. This link between the cytokeleton, cell mechanics, and motility suggests treatment options for pathologies relying on migration of cells, notably cancer metastasis.
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Chan, C. J., G. Whyte, L. Boyde, G. Salbreux, and J. Guck. "Impact of heating on passive and active biomechanics of suspended cells." Interface Focus 4, no. 2 (April 6, 2014): 20130069. http://dx.doi.org/10.1098/rsfs.2013.0069.

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A cell is a complex material whose mechanical properties are essential for its normal functions. Heating can have a dramatic effect on these mechanical properties, similar to its impact on the dynamics of artificial polymer networks. We investigated such mechanical changes by the use of a microfluidic optical stretcher, which allowed us to probe cell mechanics when the cells were subjected to different heating conditions at different time scales. We find that HL60/S4 myeloid precursor cells become mechanically more compliant and fluid-like when subjected to either a sudden laser-induced temperature increase or prolonged exposure to higher ambient temperature. Above a critical temperature of 52 ± 1°C, we observed active cell contraction, which was strongly correlated with calcium influx through temperature-sensitive transient receptor potential vanilloid 2 (TRPV2) ion channels, followed by a subsequent expansion in cell volume. The change from passive to active cellular response can be effectively described by a mechanical model incorporating both active stress and viscoelastic components. Our work highlights the role of TRPV2 in regulating the thermomechanical response of cells. It also offers insights into how cortical tension and osmotic pressure govern cell mechanics and regulate cell-shape changes in response to heat and mechanical stress.
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Ding, Yingchun, Liqi Yu, Chaomin Zhang, Huimei He, Bin Zhang, Qiang Liu, Duli Yu, and Xiaoxing Xing. "High-throughput microfluidic particle velocimetry using optical time-stretch microscopy." Applied Physics Letters 115, no. 3 (July 15, 2019): 033702. http://dx.doi.org/10.1063/1.5101015.

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Sano, Emi, Chihiro Mori, Naoki Matsuoka, Yuka Ozaki, Keisuke Yagi, Aya Wada, Koichi Tashima, et al. "Tetrafluoroethylene-Propylene Elastomer for Fabrication of Microfluidic Organs-on-Chips Resistant to Drug Absorption." Micromachines 10, no. 11 (November 19, 2019): 793. http://dx.doi.org/10.3390/mi10110793.

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Organs-on-chips are microfluidic devices typically fabricated from polydimethylsiloxane (PDMS). Since PDMS has many attractive properties including high optical clarity and compliance, PDMS is very useful for cell culture applications; however, PDMS possesses a significant drawback in that small hydrophobic molecules are strongly absorbed. This drawback hinders widespread use of PDMS-based devices for drug discovery and development. Here, we describe a microfluidic cell culture system made of a tetrafluoroethylene-propylene (FEPM) elastomer. We demonstrated that FEPM does not absorb small hydrophobic compounds including rhodamine B and three types of drugs, nifedipine, coumarin, and Bay K8644, whereas PDMS absorbs them strongly. The device consists of two FEPM layers of microchannels separated by a thin collagen vitrigel membrane. Since FEPM is flexible and biocompatible, this microfluidic device can be used to culture cells while applying mechanical strain. When human umbilical vein endothelial cells (HUVECs) were subjected to cyclic strain (~10%) for 4 h in this device, HUVECs reoriented and aligned perpendicularly in response to the cyclic stretch. Moreover, we demonstrated that this device can be used to replicate the epithelial–endothelial interface as well as to provide physiological mechanical strain and fluid flow. This method offers a robust platform to produce organs-on-chips for drug discovery and development.
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Lai, Chia-Wei, Suz-Kai Hsiung, Chia-Lun Yeh, Arthur Chiou, and Gwo-Bin Lee. "A cell delivery and pre-positioning system utilizing microfluidic devices for dual-beam optical trap-and-stretch." Sensors and Actuators B: Chemical 135, no. 1 (December 2008): 388–97. http://dx.doi.org/10.1016/j.snb.2008.08.041.

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Zhang, Huiyang, Andrew Lowe, Anubha Kalra, and Yang Yu. "A Flexible Strain Sensor Based on Embedded Ionic Liquid." Sensors 21, no. 17 (August 26, 2021): 5760. http://dx.doi.org/10.3390/s21175760.

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We present a simple-structured strain sensor based on a low-cost ionic liquid. The ionic liquid was made of sodium chloride/propylene glycol solution and was embedded in a linear microfluidic channel fabricated using Ecoflex. The proposed sensor is capable of measuring strain up to 100% with excellent repeatability. The highest gauge factor is obtained as 6.19 under direct current excitation and 3.40 under alternating current excitation at 1 kHz. The sensor shows negligible hysteresis and overshoot, and survived 10,000 rapid stretch-release cycles of a 100% peak strain with a minor deviation in the response signal. The sensor can be mounted to different locations on the human body and suits a variety of applications in the field of motion detection, human–machine interface and healthcare monitoring.
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Tang, Anson H. L., Queenie T. K. Lai, Bob M. F. Chung, Kelvin C. M. Lee, Aaron T. Y. Mok, G. K. Yip, Anderson H. C. Shum, Kenneth K. Y. Wong, and Kevin K. Tsia. "Microfluidic Imaging Flow Cytometry by Asymmetric-detection Time-stretch Optical Microscopy (ATOM)." Journal of Visualized Experiments, no. 124 (June 28, 2017). http://dx.doi.org/10.3791/55840.

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Dissertations / Theses on the topic "Microfluidic Optical Stretcher"

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Faigle, Christoph. "The Optical Stretcher." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-202092.

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The mechanical parameters of biological cells are relevant indicators of their function or of disease. For example, certain cancerous cells are more deformable than healthy cells. The challenge consists in developing methods that can measure these parameters while not affecting the cell. The Optical Stretcher is a microfluidic system that deforms single suspended cells without contact using lasers and determines the cells’ viscoelastic properties. The advantage compared to standard methods of molecular biology is that cells do not need to be treated with additional markers. Basic versions of the Optical Stretcher have existed for some years. These allow the measurement of homogeneous cell populations. Up until now, it was only possible to calculate average population values of compliance. To characterize inhomogeneous populations however, it is necessary to consider each single cell and measure additional mechanical or optical parameters such as the refractive index. This work highlights various extensions of the Optical Stretcher. A novel procedure, including an improved image processing algorithm, is presented to analyze mechanical data in real time. In combination with measurements of the optical refractive index, single cells can now be characterized in more detail. Moreover, it is now possible to extract interesting subpopulations that can be further examined with molecular biology techniques. Depending on the intended purpose, novel devices for cell measurements, based on microfluidic and optical considerations, are presented. The fundamental concept involves microstructured chips that can be integrated into a commercial microscope. These chips offer the possibility of separating measured cell populations according to their mechanical properties. This separation, including mathematical classification, is demonstrated. These methods are tested with cell types of differing mechanical properties to prove their applicability in practice. Single cells are sorted into their respective population of origin. These novel methods offer the possibility of a versatile device to be applied in biophysical research.
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Faigle, Christoph. "The Optical Stretcher: Towards a Cell Sorter Based on High-Content Analysis." Doctoral thesis, 2015. https://tud.qucosa.de/id/qucosa%3A29459.

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The mechanical parameters of biological cells are relevant indicators of their function or of disease. For example, certain cancerous cells are more deformable than healthy cells. The challenge consists in developing methods that can measure these parameters while not affecting the cell. The Optical Stretcher is a microfluidic system that deforms single suspended cells without contact using lasers and determines the cells’ viscoelastic properties. The advantage compared to standard methods of molecular biology is that cells do not need to be treated with additional markers. Basic versions of the Optical Stretcher have existed for some years. These allow the measurement of homogeneous cell populations. Up until now, it was only possible to calculate average population values of compliance. To characterize inhomogeneous populations however, it is necessary to consider each single cell and measure additional mechanical or optical parameters such as the refractive index. This work highlights various extensions of the Optical Stretcher. A novel procedure, including an improved image processing algorithm, is presented to analyze mechanical data in real time. In combination with measurements of the optical refractive index, single cells can now be characterized in more detail. Moreover, it is now possible to extract interesting subpopulations that can be further examined with molecular biology techniques. Depending on the intended purpose, novel devices for cell measurements, based on microfluidic and optical considerations, are presented. The fundamental concept involves microstructured chips that can be integrated into a commercial microscope. These chips offer the possibility of separating measured cell populations according to their mechanical properties. This separation, including mathematical classification, is demonstrated. These methods are tested with cell types of differing mechanical properties to prove their applicability in practice. Single cells are sorted into their respective population of origin. These novel methods offer the possibility of a versatile device to be applied in biophysical research.
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Lai, Chia-wei, and 賴嘉偉. "A Fiber Coupling and Cell Manipulating System Utilizing Microfluidic Devices for On-chip Dual-beam Optical Trap-and-Stretch." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/89334495899619154886.

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碩士
國立成功大學
工程科學系碩博士班
96
Fiber-dual-beam optical trap has been widely used for many applications such as the trapping or manipulation of micro-particles and cell biomechanics study. However, for these applications, precise alignment of a pair of optical fibers still remains a challenge. To tackle this issue, this study proposes a two-axis active optical-fiber manipulator for on-chip fiber alignment and optical dual beam trap applications. The chip comprising of a flow channel, air chambers, fiber channels, controllable moving walls and membrane microstructures were fabricated by using micro-electro-mechanical-systems (MEMS) technology. By adjusting air pressures to control the deflection of the pneumatic chambers placed orthogonal to and underneath the fiber channels, accurate alignment of a pair of co-axial optical-fibers, which was indicated by maximizing fiber-to-fiber coupling efficiency measured in real-time, has been achieved. A maximum displacement of a buried fiber as large as 13 μm at an applied pressure of 40 psi for one air chamber has been demonstrated. The maximum coupling efficiency for two single-mode optical-fibers facing each other at a distance of 200 μm was measured to be 4.1%. The multiple cells trapping manipulation by using the proposed chip also has been demonstrated. In addition, this study also developed a new microfluidic chip integrating the proposed fiber alignment device, cell transportation and pre-positioning systems utilizing MEMS techniques. The developed microfluidic chip is capable of delivering and pre-positioning cells in a predefined trapping zone, followed by manipulation of buried optical fibers and dual beam lasers for optical trapping, manipulation and stretcher. Experimental results showed that by integrating three micropumps connected in series, the cell samples were automatically delivered into the flow focusing area and then transported to the trapping zone. A single cell can be confined by micro-valves and then elevated towards the optical axis by a negative-DEP force operated at 20 Vp-p and 900 KHz. Finally, a red blood cell was successfully trapped, manipulated and stretched by active fiber manipulators and dual beam optical trap using the proposed microfluidic system. The developed microfluidic chip is promising for further applications that require trapping, manipulation and biomechanical analysis of a single cell or particle. Furthermore, the developed fibers alignment system is not only promising for applications requiring co-axial fibers for in-line optical analysis, but can also be easily integrated with other microfluidic systems such as capillary electrophoresis or micro flow cytometers for cell, protein, and DNA analysis.
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Book chapters on the topic "Microfluidic Optical Stretcher"

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Lau, Andy K. S., Terence T. W. Wong, Ho Cheung Shum, Kenneth K. Y. Wong, and Kevin K. Tsia. "Ultrafast Microfluidic Cellular Imaging by Optical Time-Stretch." In Imaging Flow Cytometry, 23–45. New York, NY: Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4939-3302-0_3.

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Conference papers on the topic "Microfluidic Optical Stretcher"

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Dong, Aotuo, Balaadithya Uppalapati, Md Shariful Islam, Brandon Gibbs, Ganesan Kamatchi, Sacharia Albin, and Makarand Deo. "Non-contact trapping and stretching of biological cells using dual-beam optical stretcher on microfluidic platform." In Health Monitoring of Structural and Biological Systems XIII, edited by Paul Fromme and Zhongqing Su. SPIE, 2019. http://dx.doi.org/10.1117/12.2514299.

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Volpe, Annalisa, Antonio Ancona, Gianluca Trotta, Rebeca Martínez Vázquez, Irene Fassi, and Roberto Osellame. "Fabrication and assembling of a microfluidic optical stretcher polymeric chip combining femtosecond laser and micro injection molding technologies." In SPIE LASE, edited by Udo Klotzbach, Kunihiko Washio, and Rainer Kling. SPIE, 2017. http://dx.doi.org/10.1117/12.2251372.

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Lau, Andy K. S., Terence T. W. Wong, Kenneth K. Y. Ho, Matthew Y. H. Tang, Joseph D. F. Robles, Xiaoming Wei, Antony C. S. Chan, et al. "Ultrafast high-contrast microfluidic cellular imaging by asymmetric-detection time-stretch optical microscopy (ATOM)." In Frontiers in Optics. Washington, D.C.: OSA, 2013. http://dx.doi.org/10.1364/fio.2013.fw6a.7.

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Wong, Terence T. W., Andy K. S. Lau, Matthew Y. H. Tang, Kenneth K. Y. Ho, Kenneth K. Y. Wong, Anderson H. C. Shum, and Kevin K. Tsia. "Asymmetric-detection time-stretch optical microscopy (ATOM) for high-contrast and high-speed microfluidic cellular imaging." In SPIE BiOS, edited by Daniel L. Farkas, Dan V. Nicolau, and Robert C. Leif. SPIE, 2014. http://dx.doi.org/10.1117/12.2038952.

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