Relevant bibliographies by topics / Microfluidic optical chip

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Microfluidic optical chip'

Author: Grafiati
Published: 14 March 2023

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Journal articles on the topic "Microfluidic optical chip"

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Qu, Jian, Yi Liu, Yan Li, Jinjian Li, and Songhe Meng. "Microfluidic Chip with Fiber-Tip Sensors for Synchronously Monitoring Concentration and Temperature of Glucose Solutions." Sensors 23, no. 5 (February 23, 2023): 2478. http://dx.doi.org/10.3390/s23052478.

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Monitoring the properties of fluids in microfluidic chips often requires complex open-space optics technology and expensive equipment. In this work, we introduce dual-parameter optical sensors with fiber tips into the microfluidic chip. Multiple sensors were distributed in each channel of the chip, which enabled the real-time monitoring of the concentration and temperature of the microfluidics. The temperature sensitivity and glucose concentration sensitivity could reach 314 pm/°C and −0.678 dB/(g/L), respectively. The hemispherical probe hardly affected the microfluidic flow field. The integrated technology combined the optical fiber sensor with the microfluidic chip and was low cost with high performance. Therefore, we believe that the proposed microfluidic chip integrated with the optical sensor is beneficial for drug discovery, pathological research and material science investigation. The integrated technology has great application potential for micro total analysis systems (μ-TAS).
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Adamopoulos, Christos, Asmaysinh Gharia, Ali Niknejad, Vladimir Stojanović, and Mekhail Anwar. "Microfluidic Packaging Integration with Electronic-Photonic Biosensors Using 3D Printed Transfer Molding." Biosensors 10, no. 11 (November 14, 2020): 177. http://dx.doi.org/10.3390/bios10110177.

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Multiplexed sensing in integrated silicon electronic-photonic platforms requires microfluidics with both high density micro-scale channels and meso-scale features to accommodate for optical, electrical, and fluidic coupling in small, millimeter-scale areas. Three-dimensional (3D) printed transfer molding offers a facile and rapid method to create both micro and meso-scale features in complex multilayer microfluidics in order to integrate with monolithic electronic-photonic system-on-chips with multiplexed rows of 5 μm radius micro-ring resonators (MRRs), allowing for simultaneous optical, electrical, and microfluidic coupling on chip. Here, we demonstrate this microfluidic packaging strategy on an integrated silicon photonic biosensor, setting the basis for highly multiplexed molecular sensing on-chip.
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Alhalaili, Badriyah, Ileana Nicoleta Popescu, Carmen Otilia Rusanescu, and Ruxandra Vidu. "Microfluidic Devices and Microfluidics-Integrated Electrochemical and Optical (Bio)Sensors for Pollution Analysis: A Review." Sustainability 14, no. 19 (October 9, 2022): 12844. http://dx.doi.org/10.3390/su141912844.

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An overview of the recent research works and trends in the design and fabrication of microfluidic devices and microfluidics-integrated biosensors for pollution analysis and monitoring of environmental contaminants is presented in this paper. In alignment with the tendency in miniaturization and integration into “lab on a chip” devices to reduce the use of reagents, energy, and implicit processing costs, the most common and newest materials used in the fabrication of microfluidic devices and microfluidics-integrated sensors and biosensors, the advantages and disadvantages of materials, fabrication methods, and the detection methods used for microfluidic environmental analysis are synthesized and evaluated.
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Paiè, Petra, Rebeca Martínez Vázquez, Roberto Osellame, Francesca Bragheri, and Andrea Bassi. "Microfluidic Based Optical Microscopes on Chip." Cytometry Part A 93, no. 10 (September 13, 2018): 987–96. http://dx.doi.org/10.1002/cyto.a.23589.

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Ou, Xiaowen, Peng Chen, and Bi-Feng Liu. "Optical Technologies for Single-Cell Analysis on Microchips." Chemosensors 11, no. 1 (January 3, 2023): 40. http://dx.doi.org/10.3390/chemosensors11010040.

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Cell analysis at the single-cell level is of great importance to investigate the inherent heterogeneity of cell populations and to understand the morphology, composition, and function of individual cells. With the continuous innovation of analytical techniques and methods, single-cell analysis on microfluidic chip systems has been extensively applied for its precise single-cell manipulation and sensitive signal response integrated with various detection techniques, such as optical, electrical, and mass spectrometric analyses. In this review, we focus on the specific optical events in single-cell analysis on a microfluidic chip system. First, the four most commonly applied optical technologies, i.e., fluorescence, surface-enhanced Raman spectroscopy, surface plasmon resonance, and interferometry, are briefly introduced. Then, we focus on the recent applications of the abovementioned optical technologies integrated with a microfluidic chip system for single-cell analysis. Finally, future directions of optical technologies for single-cell analysis on microfluidic chip systems are predicted.
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Kumar, Rahul, Hien Nguyen, Bruno Rente, Christabel Tan, Tong Sun, and Kenneth T. V. Grattan. "A Portable ‘Plug-and-Play’ Fibre Optic Sensor for In-Situ Measurements of pH Values for Microfluidic Applications." Micromachines 13, no. 8 (July 30, 2022): 1224. http://dx.doi.org/10.3390/mi13081224.

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Microfluidics is used in many applications ranging from chemistry, medicine, biology and biomedical research, and the ability to measure pH values in-situ is an important parameter for creating and monitoring environments within a microfluidic chip for many such applications. We present a portable, optical fibre-based sensor for monitoring the pH based on the fluorescent intensity change of an acrylamidofluorescein dye, immobilized on the tip of a multimode optical fibre, and its performance is evaluated in-situ in a microfluidic channel. The sensor showed a sigmoid response over the pH range of 6.0–8.5, with a maximum sensitivity of 0.2/pH in the mid-range at pH 7.5. Following its evaluation, the sensor developed was used in a single microfluidic PDMS channel and its response was monitored for various flow rates within the channel. The results thus obtained showed that the sensor is sufficiently robust and well-suited to be used for measuring the pH value of the flowing liquid in the microchannel, allowing it to be used for a number of practical applications in ‘lab-on-a-chip’ applications where microfluidics are used. A key feature of the sensor is its simplicity and the ease of integrating the sensor with the microfluidic channel being probed.
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KOU, Q. "On-chip optical components and microfluidic systems." Microelectronic Engineering 73-74 (June 2004): 876–80. http://dx.doi.org/10.1016/s0167-9317(04)00237-0.

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Hoera, Christian, Andreas Kiontke, Maik Pahl, and Detlev Belder. "A chip-integrated optical microfluidic pressure sensor." Sensors and Actuators B: Chemical 255 (February 2018): 2407–15. http://dx.doi.org/10.1016/j.snb.2017.08.195.

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Bissardon, Caroline, Xavier Mermet, Sophie Morales, Frédéric Bottausci, Marie Carriere, Florence Rivera, and Pierre Blandin. "Light sheet fluorescence microscope for microfluidic chip." EPJ Web of Conferences 238 (2020): 04005. http://dx.doi.org/10.1051/epjconf/202023804005.

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We present a light sheet fluorescence microscope dedicated to image “Organ-on-chip”-like biostructures in microfluidic chip. Based on a simple design, the setup is built around the chip and its environment to allow 3D imaging inside the chip in a microfluidic laboratory. The experimental setup, its optical characterization and first volumetric images are reported.
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Baczyński, Szymon, Piotr Sobotka, Kasper Marchlewicz, Artur Dybko, and Katarzyna Rutkowska. "Low-cost, widespread and reproducible mold fabrication technique for PDMS-based microfluidic photonic systems." Photonics Letters of Poland 12, no. 1 (March 31, 2020): 22. http://dx.doi.org/10.4302/plp.v12i1.981.

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In this letter the possibility of low-cost fabrication of molds for PDMS-based photonic microstructures is considered. For this purpose, three different commercially available techniques, namely UV-curing of the capillary film, 3D SLA printing and micromilling, have been analyzed. Obtained results have been compared in terms of prototyping time, quality, repeatability, and re-use of the mold for PDMS-based microstructures fabrication. Prospective use for photonic systems, especially optofluidic ones infiltrated with liquid crystalline materials, have been commented. Full Text: PDF References:K. Sangamesh, C.T. Laurencin, M. Deng, Natural and Synthetic Biomedical Polymers (Elsevier, Amsterdam 2004). [DirectLink]A. Mata et. al, "Characterization of Polydimethylsiloxane (PDMS) Properties for Biomedical Micro/Nanosystems", Biomed. Microdev. 7(4), 281 (2005). [CrossRef]I. Rodríguez-Ruiz et al., "Photonic Lab-on-a-Chip: Integration of Optical Spectroscopy in Microfluidic Systems", Anal. Chem. 88(13), 6630 (2016). [CrossRef]SYLGARD™ 184 Silicone Elastomer, Technical Data Sheet [DirectLink]N.E. Stankova et al., "Optical properties of polydimethylsiloxane (PDMS) during nanosecond laser processing", Appl. Surface Science 374, 96 (2016) [CrossRef]J.C. McDonald et al., "Fabrication of microfluidic systems in poly(dimethylsiloxane)", Electrophoresis 21(1), 27 (2000). [CrossRef]T. Fujii, "PDMS-based microfluidic devices for biomedical applications", Microelectronic Eng. 61, 907 (2002). [CrossRef]F. Schneider et al., "Process and material properties of polydimethylsiloxane (PDMS) for Optical MEMS", Sensors Actuat. A: Physical 151(2), 95 (2009). [CrossRef]T.K. Shih et al., "Fabrication of PDMS (polydimethylsiloxane) microlens and diffuser using replica molding", Microelectronic Eng. 83(11-12), 2499 (2006). [CrossRef]K. Rutkowska et al. "Electrical tuning of the LC:PDMS channels", PLP, 9, 48-50 (2017). [CrossRef]D. Kalinowska et al., "Studies on effectiveness of PTT on 3D tumor model under microfluidic conditions using aptamer-modified nanoshells", Biosensors Bioelectr. 126, 214 (2019).[CrossRef]N. Bhattacharjee et al., "The upcoming 3D-printing revolution in microfluidics", Lab on a Chip 16(10), 1720 (2016). [CrossRef]I.R.G. Ogilvie et al., "Reduction of surface roughness for optical quality microfluidic devices in PMMA and COC", J. Micromech. Microeng. 20(6), 065016 (2010). [CrossRef]D. Gomez et al., "Femtosecond laser ablation for microfluidics", Opt. Eng. 44(5), 051105 (2005). [CrossRef]Y. Hwang, R.N. Candler, "Non-planar PDMS microfluidic channels and actuators: a review", Lab on a Chip 17(23), 3948 (2017). [CrossRef]
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Dissertations / Theses on the topic "Microfluidic optical chip"

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Heinze, Brian Carl. "Lab-on-a-Chip Optical Immunosensor for Pathogen Detection." Diss., The University of Arizona, 2010. http://hdl.handle.net/10150/196023.

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This dissertation develops technology for microfluidic point-of-care (POC) immunoassay devices, divided into three papers, and explores the use of a quartz crystal microbalance for real time monitoring of blood coagulation in a fourth paper. The concept of POC testing has been well established around the world. With testing conveniently brought to the vicinity of the patient or testing site, results can be obtained in a much shorter time. There has been a global push in recent years to develop POC molecular diagnostics devices for resource-limited regions where well equipped centralized laboratories are not readily accessible. POC testing has applications in medical/veterinary diagnostics, environmental monitoring, as well as defense related testing. In the first paper, we demonstrated the use of latex immunoagglutination assays within a microfluidic chip to be an effective and sensitive method for detecting the bovine viral diarrhea virus. In the second paper the feasibility and general ease of integrating liquid core optical components onto a microfluidic lab-on-a-chip type device, for point-of-care AI diagnosis is demonstrated. In the third paper particle agglutination assays, utilizing light scattering measurements at a fixed angle from incident light delivery, for pathogen detection are explored in both Rayleigh and Mie scatter regimes through scatter intensity simulations and compared to experimental results. In the fourth paper a quartz crystal microbalance was used for real-time monitoring of fibrinogen cross-linking on three model biomaterial surfaces.
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Marchington, Robert F. "Applications of microfluidic chips in optical manipulation & photoporation." Thesis, University of St Andrews, 2010. http://hdl.handle.net/10023/1633.

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Integration and miniaturisation in electronics has undoubtedly revolutionised the modern world. In biotechnology, emerging lab-on-a-chip (LOC) methodologies promise all-integrated laboratory processes, to perform complete biochemical or medical synthesis and analysis encapsulated on small microchips. The integration of electrical, optical and physical sensors, and control devices, with fluid handling, is creating a new class of functional chip-based systems. Scaled down onto a chip, reagent and sample consumption is reduced, point-of-care or in-the-field usage is enabled through portability, costs are reduced, automation increases the ease of use, and favourable scaling laws can be exploited, such as improved fluid control. The capacity to manipulate single cells on-chip has applications across the life sciences, in biotechnology, pharmacology, medical diagnostics and drug discovery. This thesis explores multiple applications of optical manipulation within microfluidic chips. Used in combination with microfluidic systems, optics adds powerful functionalities to emerging LOC technologies. These include particle management such as immobilising, sorting, concentrating, and transportation of cell-sized objects, along with sensing, spectroscopic interrogation, and cell treatment. The work in this thesis brings several key applications of optical techniques for manipulating and porating cell-sized microscopic particles to within microfluidic chips. The fields of optical trapping, optical tweezers and optical sorting are reviewed in the context of lab-on-a-chip application, and the physics of the laminar fluid flow exhibited at this size scale is detailed. Microfluidic chip fabrication methods are presented, including a robust method for the introduction of optical fibres for laser beam delivery, which is demonstrated in a dual-beam optical trap chip and in optical chromatography using photonic crystal fibre. The use of a total internal reflection microscope objective lens is utilised in a novel demonstration of propelling particles within fluid flow. The size and refractive index dependency is modelled and experimentally characterised, before presenting continuous passive optical sorting of microparticles based on these intrinsic optical properties, in a microfluidic chip. Finally, a microfluidic system is utilised in the delivery of mammalian cells to a focused femtosecond laser beam for continuous, high throughput photoporation. The optical injection efficiency of inserting a fluorescent dye is determined and the cell viability is evaluated. This could form the basis for ultra-high throughput, efficient transfection of cells, with the advantages of single cell treatment and unrivalled viability using this optical technique.
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Lucas, Lonnie J. "Detection of Light Scattering for Lab-On-A-Chip Immunoassays Using Optical Fibers." Diss., The University of Arizona, 2007. http://hdl.handle.net/10150/193897.

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This dissertation develops technology for microfluidic point-of-care immunoassay devices. This research (2004–2007) improved microfluidic immunoassay performance by reducing reagent consumption, decreasing analysis time, increasing sensitivity, and integrating processes using a lab-on-a-chip. Estimates show that typical hospital laboratories can save $1.0 million per year by using microfluidic chips. Our first objective was to enhance mixing in a microfluidic channel, which had been one of the main barriers to using these devices. Another goal of our studies was to simplify immunoassays by eliminating surfactants. Manufacturers of latex immunoassays add surfactants to prevent non-specific aggregation of microspheres. However, these same surfactants can cause false positives (and negatives) during diagnostic testing. This work, published in Appendix A (© 2006 Elsevier) shows that highly carboxylated polystyrene (HCPS) microspheres can replace surfactants and induce rapid mixing via diffusion in microfluidic devices. Our second objective was to develop a microfluidic device using fiber optics to detect static light scattering (SLS) of microspheres in Appendix B (© 2007 Elsevier). Fiber optics were used to deliver light emitting diode (LED) or laser light. A miniature spectrometer was used to measure 45° forward light scattering collected by optical fiber. Latex microspheres coated with PR3 proteins were used to test for the vasculitis marker, anti-PR3. No false negatives or positives were observed. A limit of detection (LOD) of 50 ng mL⁻¹ was demonstrated. This optical detection system works without fluorescence or chemiluminescence markers. It is cost effective, small, and re-usable with simple rinsing. The final objective in this dissertation, published in Appendix C (© 2007 Elsevier), developed a multiplex immunoassay. A lab-on-a-chip was used to detect multiple antibodies using microsphere light scattering and quantum dot (QD) emission. We conjugated QDs onto microspheres and named this configuration “nano-on-micro” or “NOM”. Upon radiation with UV light, strong light scattering is observed. Since QDs also provide fluorescent emission, we are able to use increased light scattering for detecting antigen-antibody reactions, and decreased QD emission to identify which antibody is present.
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BERRETTONI, CHIARA. "Design, implementation and characterization of an optoelectronic platform for the detection of immunosuppressants in transplanted patients by means of a microfluidic optical chip." Doctoral thesis, Università di Siena, 2017. http://hdl.handle.net/11365/1007099.

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The past few years have seen great interest and advances in scientific research on fluorescence-based microfluidic optical sensors for clinical/medical applications. In particular, the growing demand for point-of-care-testing (POCT) devices to be applied near the patient’s bed, has driven the development of simple to use, reliable and low cost microfluidic optical platforms. The main objective of the research project presented in this thesis is the development of a novel fluorescence-based microfluidic optical chip for the simultaneous analysis of different analytes and its integration into a stand-alone POCT device. The work was undertaken in the framework of the EU project NANODEM (NANOphotonic Device for Multiple therapeutic drug monitoring - FP7-ICT-2011) that aims at developing a POCT device for the measurement of immunosuppressants in transplanted patients, characterized by a narrow therapeutic range and serious potential side effects. The benefit of this device will be an optimized dosage of the therapeutic drugs to support patient management in a clinical environment. In particular, the system will accurately measure the patient blood drug free fraction, which is considered the active fraction in terms of both drug effect and toxicity. In order to reach the low limit of detection required by the clinicians and enable the detection of the therapeutic drug free fraction, a heterogeneous binding inhibition immunoassay has been developed which makes use of antibody-coated fluorescent and magnetic nanoparticles. The microfluidic optical chip, which exploits total internal reflection fluorescence (TIRF) and fluorescence anisotropy, is constituted by an array of microfluidic channels whose surface is chemically modified with the analyte derivative. The excitation light, coming from an external source, is properly coupled and confined by total internal reflection into the optical waveguide constituting the chip, and is guided towards the sensing area. After binding with the analyte derivative immobilised on the microchannel surface, the fluorescent-magnetic nanoparticles, coated with the analyte-specific antibodies, can be excited by means of the evanescent field, which arises at the waveguide/chip surface, and the emitted fluorescence can be collected by means of large area photodiodes. A thorough study on the excitation and emission of a fluorophore near a dielectric interface was undertaken theoretically and experimentally in order to optimize the microfluidic chip design for the best fluorescence collection efficiency. Different materials have been also investigated and several chip prototypes have been realized and characterized. The final microfluidic optical chip consists of three different polymeric parts bonded together: a thin Zeonor foil (188 µm thick, R.I. = 1.53) which is used as excitation waveguide, a double side adhesive tape (140 µm thick, R.I. = 1.49), in which ten channels are structured by laser cutting and in which the heterogeneous inhibition binding immunoassay is performed, and a Zeonex slide (1 mm thick, R.I = 1.51). The developed microfluidic optical chip is capable of performing the simultaneous analysis of three different selected analytes (Tacrolimus, Cyclosporin A and Mycophenolic acid), each of them measured three times in three different channels with an additional channel for waste flowing. One of the main challenges of the work is to make the microfluidic optical chip easy to use and easy to integrate with different functional elements into a POCT device. These elements include the optoelectronic system (for both the excitation and the detection of the fluorescent signal), the magnetic trapping system (for the attraction and confinement of magnetic and fluorescent nanoparticles within the sensing area), and the fluidic system (for the automatic management of samples and reagents). Specifically, for the optoelectronic excitation system, different laser sources and different optical arrangements for the in-coupling of the light into the excitation waveguide have been experimentally evaluated and tested. An optimized butt-coupling illumination system based on an optical fibre bundle has been finally developed and integrated with the microfluidic chip. As second step of integration, the optical acquisition system, constituted of amorphous large area silicon (a-Si:H) photodiodes, absorption optical filters and readout electronics, has been properly developed in collaboration with the partners of the project. In order to favour the interaction between the fluorescent magnetic nanoparticles and the sensing layer, two magnetic trapping strategies based on current line structures (magnetic coils) and on permanent magnets have been evaluated, and a permanent magnet platform has been properly designed to be finally coupled with the microfluidic optical chip. The automatic management of the fluidics is an essential requirement for the development of POCT devices: from this point of view a fluidic system has been optimized for the implementation of the heterogeneous assay into the channels of the chip. A laboratory version of the integrated system has been developed and it can be considered as a transition setup. The final NANODEM POCT device has been finally manufactured and its functionality has been evaluated.
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Kaylor, Sean C. "Development of a Low Cost Handheld Microfluidic Phosphate Colorimeter for Water Quality Analysis." DigitalCommons@CalPoly, 2009. https://digitalcommons.calpoly.edu/theses/147.

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This thesis describes the design, fabrication, and testing process for a microfluidic phosphate colorimeter utilized for water quality analysis. The device can be powered by, and interfaced for data collection with, a common cell phone or laptop to dramatically reduce costs. Unlike commercially available colorimeters, this device does not require the user to measure or mix sample and reagent. A disposable poly(dimethylsiloxane) (PDMS) microfluid chip, powered by an absorption pumping mechanism, was used to draw water samples, mix the sample at a specific ratio with a molybdovanadate reagent, and load both fluids into an onboard cuvette for colorimetric analysis. A series of capillary retention valves, channels, and diffusion pumping surfaces passively controls the microfluidic chip so that no user input is required. The microfluidic chip was fabricated using a modified SU-8 soft lithography process to produce a 1.67mm light absorbance pathlength for optimal Beer Lambert Law color absorbance. Preliminary calibration curves for the device produced from standard phosphate solutions indicate a range of detection between 5 to 30mg/L for reactive orthophosphate with a linearity of R²=91.3% and precision of 2.6ppm. The performance of the PDMS absorption driven pumping process was investigated using flow image analysis and indicates an effective pumping rate up to approximately 7µL/min to load a 36µL sample.
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He, Yingning. "Lateral porous silicon membranes for planar microfluidic applications." Thesis, Toulouse 3, 2016. http://www.theses.fr/2016TOU30255/document.

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Les laboratoires sur puce visent à miniaturiser et à intégrer les fonctions couramment utilisées dans les laboratoires d'analyse afin de cibler des applications en santé avec un impact prometteur sur le diagnostic médical au lit du patient. Les membranes poreuses sont d'un grand intérêt pour la préparation et l'analyse d'échantillon sur puce car elles permettent la séparation par taille/charge de molécules, mais également leur pré-concentration. Parmi les matériaux disponibles pour constituer des membranes poreuses, le silicium poreux présente de nombreux avantages tels que le contrôle précis de la taille des pores et de la porosité, une chimie de surface pratique et des propriétés optiques uniques. Les membranes de silicium poreux sont généralement intégrées dans des puces fluidiques en les montant entre deux couches comportant des micro-canaux, formant ainsi des réseaux fluidiques à trois dimensions, peu pratiques et peu adaptés à l'observation directe par microscopie. Dans ces travaux de thèse, nous avons développé deux méthodes de fabrication de membranes de silicium à pores latéraux qui permettent leur intégration monolithique dans des systèmes microfluidiques planaires. Le premier procédé est fondé sur l'utilisation d'électrodes localement structurées afin de guider la formation de pores de manière horizontale, en combinaison avec des substrats type silicium sur isolant (SOI) pour localiser spatialement la formation de silicium poreux dans la profondeur du canal. La deuxième méthode repose sur le fait que la formation de silicium poreux par anodisation est fortement dépendante du type de dopant et de sa concentration. Bien que nous utilisons encore le même type d'électrodes structurées sur les parois latérales de la membrane pour injecter le courant lors de l'anodisation, le dopage par implantation permet de confiner la membrane, de façon analogue mais à la place de l'oxyde enterré du SOI. Des membranes à pores latéraux ont été fabriquées par ces deux méthodes et leur fonctionnalité a été démontrée en réalisant des expériences de filtrage. En plus de la filtration d'échantillon, les membranes ont été utilisées pour étudier la possibilité d'effectuer de la pré-concentration électrocinétique et de la détection interférométrique. La sélectivité ionique des membranes microporeuse permet la pré-concentration moléculaire avec des facteurs de concentration pouvant atteindre jusqu'à 103 en 10 min en appliquant moins de 9 V. Ces résultats sont comparables à ceux rapportés dans la littérature à l'aide par exemple de nanocanaux avec une consommation d'énergie beaucoup plus faible. Enfin, nous avons pu détecter une variation de l'indice de réfraction du silicium poreux par le décalage du spectre d'interférence lors du chargement de différents liquides injectés dans les membranes. Le travail présenté dans cette thèse constitue la première étape dans la démonstration de l'intérêt du silicium poreux pour la préparation d'échantillon et la biodétection dans des laboratoires sur puce planaires
Lab on a chip devices aim at integrating functions routinely used in medical laboratories into miniaturized chips to target health care applications with a promising impact foreseen in point-of-care testing. Porous membranes are of great interest for on-chip sample preparation and analysis since they enable size- and charge-based molecule separation, but also molecule pre-concentration by ion concentration polarization. Out of the various materials available to constitute porous membranes, porous silicon offers many advantages, such as tunable pore properties, large porosity, convenient surface chemistry and unique optical properties. Porous silicon membranes are usually integrated into fluidic chips by sandwiching fabricated membranes between two layers bearing inlet and outlet microchannels, resulting in three-dimensional fluidic networks that lack the simplicity of operation and direct observation accessibility of planar microfluidic devices. To tackle this constraint, we have developed two methods for the fabrication of lateral porous silicon membranes and their monolithic integration into planar microfluidics. The first method is based on the use of locally patterned electrodes to guide pore formation horizontally within the membrane in combination with silicon-on-insulator (SOI) substrates to spatially localize the porous silicon within the channel depth. The second method relies on the fact that the formation of porous silicon by anodization is highly dependent on the dopant type and concentration. While we still use electrodes patterned on the membrane sidewalls to inject current for anodization, the doping via implantation enables to confine the membrane analogously to but instead of the SOI buried oxide box. Membranes with lateral pores were successfully fabricated by these two methods and their functionality was demonstrated by conducting filtering experiments. In addition to sample filtration, we have achieved electrokinetic pre-concentration and interferometric sensing using the fabricated membranes. The ion selectivity of the microporous membrane enables to carry out sample pre-concentration by ion concentration polarization with concentration factors that can reach more than 103 in 10 min by applying less than 9 V across the membrane[TL1]. These results are comparable to what has already been reported in the literature using e.g. nanochannels with much lower power consumption. Finally, we were able to detect a change of the porous silicon refractive index through the shift of interference spectrum upon loading different liquids into the membrane. The work presented in this dissertation constitutes the first step in demonstrating the interest of porous silicon for all-in-one sample preparation and biosensing into planar lab on a chip
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Schembri, Florinda. "Experimental study for the control of two-phase microfluidic flows." Thesis, Universita' degli Studi di Catania, 2011. http://hdl.handle.net/10761/366.

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Microfluidic systems can be considered as nonlinear dynamical systems. In the perspective of control systems toward the development of highly integrated and portable Lab on a Chip systems (LOC), is of primary importance the identification of the nonlinear processes involved in such phenomena. The main aims achieved in this PhD thesis are: the identification of input-output relation maps for the two-phase flow patterns, the design of innovative PDMS micro-optical systems for microfluidics' monitoring, the parameters estimation of a mathematical model by means of synchronization of two dynamical systems. These experimental studies open the way for the control of two-phase microfluidic flows through signal processing.
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Harazim, Stefan M. "Rolled-up microtubes as components for Lab-on-a-Chip devices." Doctoral thesis, Universitätsbibliothek Chemnitz, 2012. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-100312.

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Rolled-up nanotechnology based on strain-engineering is a powerful tool to manufacture three-dimensional hollow structures made of virtually any kind of material on a large variety of substrates. The aim of this thesis is to address the key features of different on- and off-chip applications of rolled-up microtubes through modification of their basic framework. The modification of the framework pertains to the tubular structure, in particular the diameter of the microtube, and the material which it is made of, hence achieving different functionalities of the final rolled-up structure. The tuning of the microtube diameter which is adjusted to the individual size of an object allows on-chip studies of single cells in artificial narrow cavities, for example. Another modification of the framework is the addition of a catalytic layer which turns the microtube into a self-propelled catalytic micro-engine. Furthermore, the tuneability of the diameter can have applications ranging from nanotools for drilling into cells, to cargo transporters in microfluidic channels. Especially rolled-up microtubes based on low-cost and easy to deposit materials, such as silicon oxides, can enable the exploration of novel systems for several scientific topics. The main objective of this thesis is to combine microfluidic features of rolled-up structures with optical sensor capabilities of silicon oxide microtubes acting as optical ring resonators, and to integrate these into a Lab-on-a-Chip system. Therefore, a new concept of microfluidic integration is developed in order to establish an inexpensive, reliable and reproducible fabrication process which also sustains the optical capabilities of the microtubes. These integrated microtubes act as optofluidic refractrometric sensors which detect changes in the refractive index of analytes using photoluminescence spectroscopy. The thesis concludes with a demonstration of a functional portable sensor device with several integrated optofluidic sensors
Die auf verspannten Dünnschichten basierende „rolled-up nanotechnologie“ ist eine leistungsfähige Methode um dreidimensionale hohle Strukturen (Mikroröhrchen) aus nahezu jeder Art von Material auf einer großen Vielfalt von Substraten herzustellen. Ausgehend von der Möglichkeit der Skalierung des Röhrchendurchmessers und der Modifikation der Funktionalität des Röhrchens durch Einsatz verschiedener Materialien und Oberflächenfunktionalisierungen kann eine große Anzahl an verschiedenen Anwendungen ermöglicht werden. Eine Anwendung behandelt unter anderem on-chip Studien einzelner Zellen wobei die Mikroröhrchen, an die Größe der Zelle angepasste, Reaktionscontainer darstellen. Eine weitere Modifikation der Funktionalität der Mikroröhrchen kann durch das Aufbringen einer katalytischen Schicht realisiert werden, wodurch das Mikroröhrchen zu einem selbstangetriebenen katalytischen Mikro-Motor wird. Hauptziel dieser Arbeit ist es Mikrometer große optisch aktive Glasröhrchen herzustellen, diese mikrofluidisch zu kontaktieren und als Sensoren in Lab-on-a-Chip Systeme zu integrieren. Die integrierten Glasröhrchen arbeiten als optofluidische Ringresonatoren, welche die Veränderungen des Brechungsindex von Fluiden im inneren des Röhrchens durch Änderungen im Evaneszenzfeld detektieren können. Die Funktionsfähigkeit eines Demonstrators wird mit verschiedenen Flüssigkeiten gezeigt, dabei kommt ein Fotolumineszenz Spektrometer zum Anregen des Evaneszenzfeldes und Auslesen des Signals zum Einsatz. Die entwickelte Integrationsmethode ist eine Basis für ein kostengünstiges, zuverlässiges und reproduzierbares Herstellungsverfahren von optofluidischen Mikrochips basierend auf optisch aktiven Mikroröhrchen
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Fu, Yi. "Conception, fabrication et expérimentation de systèmes microfluidiques de CULTU." Thesis, Paris Est, 2014. http://www.theses.fr/2014PEST1165/document.

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Dans cette thèse, deux dispositifs de culture in vitro de cellules ont été développés selon des technologies de microfabrication, qui offrent de nouveaux niveaux de contrôle sur le microenvironnement de la culture cellulaire. Les applications des dispositifs développés dans la recherche sur le cancer et la neurobiologie ont été démontrées, notamment pour l'étude fondamentale de métastases du cancer et le pathfinding axonal de neurones. La puce microfluidique dédiée à la transmigration comprend des microcanaux utilisées pour mimer les capillaires des tissus le long de la trajectoire des cellules cancéreuses lors de la métastase. La transparence optique du dispositif a permis une bonne observation de la déformation et de la migration des cellules dans les capillaires artificiels. Les résultats ont montré que la déformation du noyau de la cellule rigide était une des étapes les fastidieuses du processus de transmigration. Les restrictions physiques modifient la morphologie des cellules, mais elles affectent aussi de manière significative leur profil de migration. D'autres études sur le contenu moléculaire et les propriétés biologiques des cellules transmigrées ont montré que le blocage des modifications des histones par un médicament spécifique peut inhiber la transmigration des cellules cancéreuses dans le microcanal, ce qui pourrait avoir des implications sur la prévention et le traitement du cancer. La puce microfluidique peut également être utilisée pour évaluer la déformabilité de la cellule, qui est un marqueur pronostique potentiel pour le diagnostic du cancer. La puce de la culture de neurones permet la culture de cellules dans un microenvironnement au sein duquel de protéines sont imprimées selon des motifs géométriques précis. Les somas et axones des neurones mis en culture dans le dispositif peuvent être polarisés dans différents environnements fluidiquement isolés sur une longue période. L'extension des axones peut être guidée par des protéines immobilisées sur le substrat de verre. La croissance axonale orientée peut en outre être modulée par un traitement médicamenteux localisé. Les études sur le mécanisme moléculaire sous-jacent ont révélé que ces processus ont été étroitement associés à des protéines synthétisées localement dans les extrémités d'axones en croissance
In this PhD project, two in vitro cell culture devices were developed via microfabrication technologies, which provided entirely new levels of controls over the cell culture microenvironment. The applications of the developed devices in cancer and neurobiology researches were demonstrated, specifically for the fundamental study of cancer metastasis and neural axonal pathfinding. The microfluidic transmigration chip used microchannel structures to mimic the tissue capillaries along the path of cancer cell metastasis. The transparent optical qualities of the device allowed good observation of the deformation and migration of cells in the artificial capillaries. Results showed that deformation of the stiff cell nucleus were the most time-consuming steps during the transmigration process. The physical restrictions not only changed the morphology of the cells, but also significantly affect their migration profile. Further studies on the molecular contents and biological properties of the transmigrated cells showed that blocking the histone modifications by specific drug can inhibit the transmigration of cancer cells in the microchannel, which might have implications on cancer prevention and treatment. The microfluidic chip can also be used to evaluate cell deformability, which is a potential prognostic marker for cancer diagnosis. The neural culture chip integrated microfluidic cell culture and protein patterning techniques. The somas and axons of neurons cultured in the device can be polarized into different fluidically isolated environments for long period, and the extension of the axons can be guided by proteins immobilized on the glass substrate into specific patterns. The oriented axon growth can be further modulated by localized drug treatment. Studies on the underlying molecular mechanism revealed that these processes were closely associated with the proteins synthesized locally in the tips of growing axons
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Shen, Li. "PORTABLE MULTIPLEXED OPTICAL DETECTION FOR POINT-OF-CARE." University of Cincinnati / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1367943692.

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Books on the topic "Microfluidic optical chip"

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Nanobiosensors for Personalized and Onsite Biomedical Diagnosis. Institution of Engineering & Technology, 2016.

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Book chapters on the topic "Microfluidic optical chip"

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Rasooly, Avraham, Yordan Kostov, and Hugh A. Bruck. "Charged-Coupled Device (CCD) Detectors for Lab-on-a Chip (LOC) Optical Analysis." In Microfluidic Diagnostics, 365–85. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-62703-134-9_23.

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Wang, Xiaolin, Shuxun Chen, and Dong Sun. "Robot-Aided Micromanipulation of Biological Cells with Integrated Optical Tweezers and Microfluidic Chip." In Advanced Micro and Nanosystems, 393–416. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2015. http://dx.doi.org/10.1002/9783527690237.ch16.

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Osellame, R., R. Martinez Vazquez, C. Dongre, R. Dekker, H. J. W. M. Hoekstra, M. Pollnau, R. Ramponi, and G. Cerullo. "Femtosecond laser fabrication for the integration of optical sensors in microfluidic lab-on-chip devices." In Springer Series in Chemical Physics, 973–75. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-95946-5_315.

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Gai, Hongwei, Yongjun Li, and Edward S. Yeung. "Optical Detection Systems on Microfluidic Chips." In Microfluidics, 171–201. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/128_2011_144.

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Schmidt, Holger. "On-Chip Micro-optical Detection." In Encyclopedia of Microfluidics and Nanofluidics, 2513–18. New York, NY: Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4614-5491-5_1152.

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Schmidt, Holger. "On-Chip Micro-optical Detection." In Encyclopedia of Microfluidics and Nanofluidics, 1–8. Boston, MA: Springer US, 2014. http://dx.doi.org/10.1007/978-3-642-27758-0_1152-2.

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Lucas, Lonnie J., and Jeong-Yeol Yoon. "On-Chip Detection Using Optical Fibers." In Encyclopedia of Microfluidics and Nanofluidics, 2484–502. New York, NY: Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4614-5491-5_1145.

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Lucas, Lonnie J., and Jeong-Yeol Yoon. "On-Chip Detection Using Optical Fibers." In Encyclopedia of Microfluidics and Nanofluidics, 1–19. Boston, MA: Springer US, 2014. http://dx.doi.org/10.1007/978-3-642-27758-0_1145-2.

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Ibarlucea, Bergoi, Julian Schütt, Larysa Baraban, Denys Makarov, Mariana Medina Sanchez, and Gianaurelio Cuniberti. "Real-Time Tracking of Individual Droplets in Multiphase Microfluidics." In Microfluidics and Nanofluidics - Fundamentals and Applications [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.106796.

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Multiphase microfluidics enables the high-throughput manipulation of droplets for multitude of applications, from the confined fabrication of nano- and micro-objects to the parallelization of chemical reactions of biomedical or biological interest. While the standard methods to follow droplets on a chip are represented by a visual observation through either optical or fluorescence microscopy, the conjunction of microfluidic platforms with miniaturized transduction mechanisms opens new ways towards the real-time and individual tracking of each independent reactor. Here we provide an overview of the most recent droplet sensing techniques, with a special focus on those based on electrical signals for an optics-less analysis.
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Kumar Chourasia, Ritesh, Nitesh K. Chourasia, Ankita Srivastava, and Narendra Bihari. "Photonic Nanostructured Bragg Fuel Adulteration Sensor." In Photonic Materials: Recent Advances and Emerging Applications, 237–64. BENTHAM SCIENCE PUBLISHERS, 2023. http://dx.doi.org/10.2174/9789815049756123010015.

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The adulteration of liquid fuels has several far-reaching repercussions, including pollution and a rising energy crisis. Around the world, fossil fuels are widely utilized for transportation and energy generation. Fuel adulteration currently threatens a big number of customers. Adulteration of fossil fuels with other recognised hydrocarbons is a common occurrence. Adulterants are added to these base fuels in the form of additional low-cost hydrocarbons with similar compositions, leading the base to be altered and degraded. Adulteration is an unauthorised or illegal introduction of a lower-quality external substance into a higher-quality commodity, causing the latter to lose its original composition and qualities. The Opto-Microfluidics approach is a new field that uses a small sample to identify adulteration in food and fuel, resulting in high-resolution findings. Consumers will benefit from very sensitive detection of dangerous adulteration in any commodity thanks to opto-microfluidic lab-on-chip technologies. Using the metal-polymer nanocomposites’ multilayer cylindrical nanostructure with a microfluidic channel, we develop a real-time and temperature dependent prototype of the Bragg Opto-microfluidic sensor for effective tracking of contaminated fossil fuels. The purpose of this chapter is to examine the biological motivations for the development of multilayer photonic nanostructures and various types of fuel adulteration detection optical sensors using various sensor-based techniques, as well as to compare the Bragg Metal-Polymer nanocomposites optical sensor with other optical sensors. This chapter is devoted entirely to the use of the theoretical model's Kay, Eykman, Dale-Gladstone, Newton, and Lorentz-Lorenz, as well as Hankel formalism and the transfer matrix method for cylindrical symmetry.
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Conference papers on the topic "Microfluidic optical chip"

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Zhang, Lei, and Limin Tong. "Microfluidic chip based microfiber sensors." In Optical Sensors. Washington, D.C.: OSA, 2015. http://dx.doi.org/10.1364/sensors.2015.ses2b.4.

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Zhang, Lei, and Limin Tong. "Microfluidic chip based microfiber/nanofiber sensors." In 25th International Conference on Optical Fiber Sensors, edited by Youngjoo Chung, Wei Jin, Byoungho Lee, John Canning, Kentaro Nakamura, and Libo Yuan. SPIE, 2017. http://dx.doi.org/10.1117/12.2264873.

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Chandrasekaran, Arvind, and Muthukumaran Packirisamy. "Integrated optical microfluidic lab-on-a-chip." In Photonics North 2008, edited by Réal Vallée, Michel Piché, Peter Mascher, Pavel Cheben, Daniel Côté, Sophie LaRochelle, Henry P. Schriemer, Jacques Albert, and Tsuneyuki Ozaki. SPIE, 2008. http://dx.doi.org/10.1117/12.807550.

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Ghirardini, Lavinia, Anne-Laure Baudrion, Marco Monticelli, Daniela Petti, Giovanni Pellegrini, Lamberto Duò, Paolo Biagioni, Marco Finazzi, Pierre-Michel Adam, and Michele Celebrano. "Plasmon-enhanced second-harmonic sensing on a microfluidic chip." In Optical Sensors. Washington, D.C.: OSA, 2018. http://dx.doi.org/10.1364/sensors.2018.seth1a.2.

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Ribeiro, A. R., I. Martinho, J. B. Tillak, I. Bernacka-Wojcik, D. Barata, P. A. S. Jorge, H. Águas, and A. G. Oliva. "Microfluidic chip for spectroscopic and refractometric analysis." In OFS2012 22nd International Conference on Optical Fiber Sensor, edited by Yanbiao Liao, Wei Jin, David D. Sampson, Ryozo Yamauchi, Youngjoo Chung, Kentaro Nakamura, and Yunjiang Rao. SPIE, 2012. http://dx.doi.org/10.1117/12.975248.

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Su, Bo, Yanqiu Li, and Hongguang Sun. "Novel fabrication technology of polydimethylsiloxane microfluidic chip." In 3rd International Symposium on Advanced Optical Manufacturing and Testing Technologies: Design, Manufacturing, and Testing of Micro- and Nano-Optical Devices and Systems, edited by Sen Han, Tingwen Xing, Yanqiu Li, and Zheng Cui. SPIE, 2007. http://dx.doi.org/10.1117/12.782732.

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Leistiko, Otto. "Integrated microfluidic-optical detection system on a chip." In BiOS '97, Part of Photonics West, edited by Paul L. Gourley. SPIE, 1997. http://dx.doi.org/10.1117/12.269959.

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Tonouchi, Masayoshi. "Terahertz microfluidic chip sensitivity-enhanced with a few arrays of meta atoms." In Optical Sensors. Washington, D.C.: OSA, 2018. http://dx.doi.org/10.1364/sensors.2018.seth4e.1.

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Espina Palanco, Marta, Darmin Catak, Rodolphe Marie, Marco Matteucci, Brian Bilenberg, Anders Kristensen, and Kirstine Berg-Sørensen. "Optical two-beam trap in a polymer microfluidic chip." In SPIE Nanoscience + Engineering, edited by Kishan Dholakia and Gabriel C. Spalding. SPIE, 2016. http://dx.doi.org/10.1117/12.2236465.

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Jingjing, Zhao, and You Zheng. "Combining microfluidic chip and binary optical element for flow cytometry." In 2016 IEEE SENSORS. IEEE, 2016. http://dx.doi.org/10.1109/icsens.2016.7808676.

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