Academic literature on the topic 'Microdomain organisation'
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Journal articles on the topic "Microdomain organisation"
Röder, Ira Verena, Valentina Lissandron, Jessica Martin, Yvonne Petersen, Giulietta Di Benedetto, Manuela Zaccolo, and Rüdiger Rudolf. "PKA microdomain organisation and cAMP handling in healthy and dystrophic muscle in vivo." Cellular Signalling 21, no. 5 (May 2009): 819–26. http://dx.doi.org/10.1016/j.cellsig.2009.01.029.
Full textLechner, Bob-Dan, Paul Smith, Beth McGill, Skye Marshall, Jemma L. Trick, Andrei P. Chumakov, Charles Peter Winlove, Oleg V. Konovalov, Christian D. Lorenz, and Peter G. Petrov. "The Effects of Cholesterol Oxidation on Erythrocyte Plasma Membranes: A Monolayer Study." Membranes 12, no. 9 (August 24, 2022): 828. http://dx.doi.org/10.3390/membranes12090828.
Full textJanas, T., K. Nowotarski, W. I. Gruszecki, and T. Janas. "The effect of hexadecaprenol on molecular organisation and transport properties of model membranes." Acta Biochimica Polonica 47, no. 3 (September 30, 2000): 661–73. http://dx.doi.org/10.18388/abp.2000_3987.
Full textFantini, Jacques, Nicolas Garmy, Radhia Mahfoud, and Nouara Yahi. "Lipid rafts: structure, function and role in HIV, Alzheimer's and prion diseases." Expert Reviews in Molecular Medicine 4, no. 27 (December 20, 2002): 1–22. http://dx.doi.org/10.1017/s1462399402005392.
Full textDissertations / Theses on the topic "Microdomain organisation"
Eichel, Catherine. "Organisation et régulation des canaux sodiques et potassiques cardiaques par les protéines MAGUK." Thesis, Paris 6, 2014. http://www.theses.fr/2014PA066157/document.
Full textThe aim of the thesis was to understand how ion channels are addressed, organized and regulated in specialized domains of the plasma membrane of cardiac myocytes. Among these partners, the MAGUK proteins (Membrane Associated GUanylate Kinase) are specialized in anchoring, aggregation and clustering of macromolecular complexes at the plasma membrane. In particular, characterized for the first time at the level of the hearth, one of these MAGUK proteins is the CASK protein. CASK is localized at the lateral membrane of cardiomyocytes, but excluded from intercalated disks which are privilege zones of the longitudinal axial conduction. At the lateral membrane, CASK protein is expressed among the costameric dystrophin/glycoproteins complex. CASK inhibition leads to the increase in sodium current density in HEK293 cells and in cardiomyocytes. In HEK293, evanescent wave microscopy (TIRF) and biotinylation experiments pointed out that the INa increase is associated to an increase in the number of NaV1.5 channels at the plasma membrane. Scanning ion conductance microscopy (SICM) coupled to cell-attached patch-clamp has demonstrated that CASK holds together sodium channels at the crest level and prevents their aggregation into clusters in the T-tubules. Finally, inhibition of CASK, in vivo, using an adeno-associated virus strategy resulted to an increase in duration of ventricular depolarization and to the appearance of dilated cardiomyopathy
Toubiana, Julie. "Signalisation de TLR2, organisation et variabilité de la réponse immunitaire innée." Paris 5, 2010. http://www.theses.fr/2010PA05T016.
Full textHost invasion by micro-organisms induces an innate immune response that leads to cell activation, inflammation and potentially to the initiation of an adaptative response. Major differences are found within the organisation of innate immune responses depending on the pathogen, the invaded cell-type and the host itself. Initiation and organisation of innate immune responses facing bacteria, parasites, or fungi need the cooperation of Toll-like receptor 2 (TLR2) with TLR1 or TLR6, and multimolecular complexes in lipid rafts that determine a specific response. However, our understanding of molecular interactions within lipid rafts remains cryptic. Specifically, little is known regarding the composition of signaling complexes induced by distinct pathogens and the activation mechanisms involved in the initiation and regulation of a potent inflammatory response. The aim of this research project was to investigate the mechanisms involved in recognition and signaling downstream TLR2, and factors that account for variability of the inflammatory phenotype. For this purpose, we established a differential proteomic strategy to identiy the composition of TLR2 activation cluster and post-translationnal modifications of proteins after the recruitment of TLR2 dimers to lipid rafts. This approach enabled us to identify tyrosine-kinase Lyn and IMPDHII as essential regulators of TLR2 signaling. In a translational approach, we studied the effect of an haplotype of IRAKI gene, which codes for a key signaling protein downstream TLRs, on clinical variability in patients with septic shock. Our results provide new insights in ogranisation, regulation and variability of innate imune response
Bezzaoucha, Fatiha. "Nouveaux polyamphiphiles cationiques : synthèse et étude de leur organisation en milieu aqueux et aux interfaces en relation avec leur structure." Thesis, Vandoeuvre-les-Nancy, INPL, 2008. http://www.theses.fr/2008INPL026N/document.
Full textIn order to improve the fundamental knowledge of the relationships between the chemical structure of intramolecular associative polymers (polysoaps) and their physical chemical properties in aqueous media, three new families of cationic amphiphilic polymers were obtained by complementary methods offering great structure variability. The corresponding polymers were comb poly(meth)acrylamides with pendant ammonium groups with alkyl side chains of variable lengths. A first investigation of their physical chemical behaviour in aqueous solutions, by viscometry and fluorescence spectrometry with two complementary fluorescent probes, showed that they displayed polysoap properties which varied progressively with their chemical features, in particular the length of the alkyl side chain, the size of the spacer between the two polar amide and ammonium groups and the polymer molecular weight. Tensiometry confirmed the prevailing of the hydrophobic effect by showing that these polymers displayed a very weak activity at the water/air interface although the corresponding molecular models showed excellent tensio-active properties. Langmuir’s films were eventually obtained in the first study of this importance on cationic amphiphilic polymers. Here again, the great structural variability enabled original observations and new structure/properties relationships were obtained for the corresponding compression isotherms
Schäfers, Sonja [Verfasser]. "Annexin A2 in membrane microdomain organisation and influenza A infection / vorgelegt von Sonja Schäfers." 2010. http://d-nb.info/1003549209/34.
Full textMedvedev, Roman. "Structural and functional differences between cardiomyocytes from right and left ventricles in health and disease." Doctoral thesis, 2020. http://hdl.handle.net/11562/1017728.
Full textSieber, Jochen Josef. "Der Syntaxin 1-Cluster - Organisation und Dynamik einer supramolekularen Struktur der Plasmamembran." Doctoral thesis, 2007. http://hdl.handle.net/11858/00-1735-0000-0006-AC62-5.
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