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Dissertations / Theses on the topic 'Microbial peptides'

Author: Grafiati

Published: 4 June 2021

Last updated: 7 September 2023

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1

Kwok, Hoi-shan, and 郭凱珊. "The comparison of biological properties of L- and D-enantiomeric antimicrobial peptides." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/206507.

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Antibiotics have been used widely for the treatment of bacterial infections for over half a century. However, the emergence of resistance to antibiotics has aroused public health concern, leading to the development of antimicrobial peptides (AMPs) as potential alternative therapeutic agents against bacterial infections. AMPs are naturally found in many species and have important roles in our innate immune defense systems. AMPs are usually cationic amphipathic peptides with membrane destabilizing property. They have a relatively broad spectrum of antimicrobial activity and pathogens are less li

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2

Zhou, Yu. "Studies on anti-microbial peptides and other bioactive peptides from skin secretions of phyllomedusine frogs." Thesis, Queen's University Belfast, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.534594.

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3

Chia, Brian Cheng San. "Amphibian antimicrobial peptides : their structures and mechanisms of action : a thesis presented for the degree of Doctor of Philosophy." Title page, contents and abstract only, 2000. http://web4.library.adelaide.edu.au/theses/09PH/09phc532.pdf.

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Copy of author's previously published works inserted. Bibliography: leaves 183-220. Three antimicrobial peptides, maculatin 1.1, uperin 3.6 and caerin 4.1 have been isolated from the respective skin glands of the Australian amphibians Litoria genimaculata, Uperoleia mjobergii and Litoria caerulea. To gain a deeper insight into their mechanisms of action, three dimensional structural studies have been conducted using circular dichroism, two-dimensional nuclear resonance and computer modelling techniques. The role of central flexibility within antibiotic peptides in their interaction with bacter

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4

Chen, Heru. "Preparation and biological evaluation of the loloatins and their analogues /." View Abstract or Full-Text, 2002. http://library.ust.hk/cgi/db/thesis.pl?CHEM%202002%20CHEN.

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5

Wilson, Sarah, and n/a. "Vaccine peptide delivery by virus particles." University of Otago. Department of Microbiology & Immunology, 2007. http://adt.otago.ac.nz./public/adt-NZDU20080131.161222.

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Vaccination with immunogenic peptides offers a safe and specific way of inducing protection against pathogens, however as of yet there are no peptide-based vaccines available. The limitations on the therapeutic use of peptides are due to their poor immunogenicity and short life span in vivo. Peptide delivery systems act to circumvent these issues. The aims of this research were to investigate the ability of virus-like particles (VLP) from Rabbit haemmorhagic disease virus (RHDV) to deliver immunogenic peptides, to characterize the immune response to these particles, and to investigate whether

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6

Wabnitz, Paul Andrew. "Chemistry and medical implications of novel amphibian peptides : a thesis submitted for the degree of Doctor of Philosophy /." Title page, contents and abstract only, 1999. http://web4.library.adelaide.edu.au/theses/09PH/09phw112.pdf.

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7

Brewster, Rachel Elizabeth. "Synthesis of small molecules with specific function : I. Peptidocalix[4]arenes as molecular receptors ; II. Towards the total synthesis of (-)-Dihydroguaiaretic acid." Diss., Available online, Georgia Institute of Technology, 2004:, 2004. http://etd.gatech.edu/theses/available/etd-06072004-131103/unrestricted/brewster%5Frachel%5Fe%5F200405%5Fphd.pdf.

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8

Limoli, Dominique H. "Investigating the host and microbial determinants of Pseudomonas aeruginosa mucoid conversion." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1406024226.

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9

Lu, Qian. "Expression and regulation of human [beta]-defensins in gingival epithelia." Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36613708.

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10

Besse, Alison. "Interactions microbiennes et adaptations en milieu extrême : peptides antimicrobiens d’archées halophiles." Thesis, Paris, Muséum national d'histoire naturelle, 2016. http://www.theses.fr/2016MNHN0007/document.

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Les archées halophiles sont des procaryotes vivant dans des conditions d’extrême salinité. Ces micro-organismes colonisent les environnements hypersalins et synthétisent des peptides antimicrobiens appelés halocines, qui pourraient leur conférer un avantage sélectif sur leurs compétiteurs. Parmi les peptides antimicrobiens d’archées halophiles décrits, on distingue l’halocine C8, initialement purifiée à partir de la souche halophile Natrinema sp. AS7092. Ce travail de thèse a permis de montrer que la production d’halocine C8 était conservée chez plusieurs archées halophiles appartenant aux gen

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11

Morgan, Joanne. "Screening, isolation and characterisation of antimicrobial/antifungal peptides produced by lactic acid bacteria isolated from wine." Thesis, Stellenbosch : Stellenbosch University, 2003. http://hdl.handle.net/10019.1/53582.

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Thesis (MSc)--Stellenbosch University, 2003.<br>Full text to be digitised and attached to bibliographic record.<br>ENGLISH ABSTRACT: Winemaking is an age-old tradition that dates back to as early as 6000 BC. In our modern era there are several insects and microorganisms that pose a threat to the grapevine, the environment and the final wine product. Farmers and winemakers are becoming aware of the threat and the fight against disease, spoilage and/or pathogenic microorganisms is on the rise. Currently, the natural environment is being altered through rural developments, pollution and disa

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12

Lu, Qian, and 陸茜. "Expression and regulation of human {221}-defensins in gingival epithelia." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B36613708.

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13

Holroyd, Dale. "Atomic force microscopy : a novel tool for the analysis of the mechanism of action of antimicrobial peptides on target membranes." Thesis, Stellenbosch : Stellenbosch University, 2003. http://hdl.handle.net/10019.1/53306.

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Thesis (MSc)--Stellenbosch University, 2003.<br>ENGLISH ABSTRACT: Nanoscale visualisation of live cells and cellular components under physiological conditions has long been a goal in microscopy. The objective of this study was to validate the use of Atomic Force Microscopy (AFM) as a new tool in unravelling the mysteries of antimicrobial peptide mechanism of action. Using the simplest AFM imaging technique, we were able to analyse the influence of haemolytic melittin and anti-bacterial magainin 2 on different target membranes at nanometer resolution, without using fixing agents. First,

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14

Miranda, Ceres Maciel de. "Expressão de microplusina em Aedes aegypti: avaliação do efeito sobre Plasmodium gallinaceum." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/42/42135/tde-04082011-091317/.

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A transmissão de parasitas da malária por mosquitos vetores é dependente do desenvolvimento bem sucedido das formas infectantes de Plasmodium sp., especialmente os esporozoítas, que são as formas que infectam o hospedeiro vertebrado. A manipulação genética de mosquitos vetores tem sido uma estratégia alternativa na tentativa de controle da malária. Um componente extremamente importante desta estratégia é a escolha de uma molécula efetora capaz de reduzir a transmissão do patógeno. Microplusina é um peptídeo antimicrobiano rico em cisteína, originalmente descrito como um componente antimicrobia

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15

NASH, JAMES ANDREW. "THE PEPTIDOGLYCAN-DEGRADING PROPERTY OF LYSOZYME IS NOT REQUIRED FOR BACTERICIDAL ACTIVITY, IN VIVO." University of Cincinnati / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1135957476.

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16

Rizk, Ziad. "Impact and identification of inhibitory peptides released by Saccharomyces cerevisiae on the malolactic fermentation." Phd thesis, Toulouse, INPT, 2016. http://oatao.univ-toulouse.fr/19390/1/Ziad_Rizk.pdf.

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The production of most red wines and certain white and sparkling wine styles requires two consecutive fermentation steps. The first one is the alcoholic fermentation (AF) and is carried out mainly by Saccharomyces cerevisiae. At the end of the AF, the wines undergo malolactic fermentation (MLF) carried out mainly by Oenococcus oeni. However, the MLF is often difficult to trigger and accomplish because of the individual or synergistic antibacterial activity of several physical chemical wine parameters and yeast inhibitory metabolites. In this context, the study of the interactions that may occu

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17

Wang, Peng. "Studies on E. Coli Membrane Protein Biogenesis: Mechanism of Signal Peptide Peptidase A and the Influence of YiDC Depletion on Cellular Processes." Columbus, Ohio : Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view.cgi?acc%5Fnum=osu1243982038.

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18

Hubert, Marie. "Structure de mycotoxines et d'analogues- recherche de leurs métabolites chez un insecte hôte." Rouen, 1998. http://www.theses.fr/1998ROUES037.

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Dans l'optique d'utiliser les mycotoxines en tant que bioinsecticides potentiels de nouvelle génération, nous nous sommes intéressés à celles de deux champignons entomopathogènes, Metarhizium anisopliae et Paecilomyces farinosus. Celles de M. Anisopliae, les destruxines (DTXs), sont des cyclohexadepsipeptides connus depuis plusieurs décennies. Sur le plan structural, une systématique de fragmentation de ces composés a été mise au point par PFAB/MS/Linked Scan. Au niveau biologique, nous avons complété les études sur le comportement in vivo des destruxines. Les métabolites des DTXs A et E, dest

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19

Leite, Suzan Blima Paulino. "Efluentes do processamento de Minced de tilápia reaproveitados como coprodutos com atividade antioxidante e para uso como meio de cultura em bioprocessos." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/64/64135/tde-14072016-142959/.

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A água residual do processamento do Minced de tilápia (Oreochromis niloticus) é descartada sem qualquer aproveitamento, constituindo um efluente de potencial impacto ao ambiente. O objetivo desse estudo foi avaliar este efluente, caracterizar sua fração proteica, verificar seu potencial antioxidante e sua eficiência como meio de cultura para o crescimento microbiano. A carne mecanicamente separada (CMS) de tilápia foi submetida à operação de clarificação em água destilada a 10ºC, na proporção 1:3, processo que se constituiu em homogeneização por 3 min, repouso por 3 min, sendo o Minced acondic

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20

Tayou, Junior Kom. "Requirement of ßDELSEED-Motif of Escherichia coli F₁F_O ATP Synthase in Antimicrobial Peptide Binding." Digital Commons @ East Tennessee State University, 2011. https://dc.etsu.edu/etd/1260.

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F1FO ATP synthase is a membrane bound enzyme capable of synthesizing and hydrolyzing ATP. Lately, α-helical cationic peptides such as melittin and melittin related peptide (MRP) were shown to inhibit E. coli ATP synthase. The proposed but unconfirmed site of inhibition is βDELSEED-motif formed by the residues 380-386, located at the interface of α/β subunit of ATP synthase. This project was a mutagenic analysis of βDELSEED-motif residues to understand the binding mechanism and mode of action of peptide inhibitors. The study addressed 2 main questions: Are the antibacterial/anticancer effects o

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21

Winkle, Sean M., Andrea L. Throop та Melissa M. Herbst-Kralovetz. "IL-36γ Augments Host Defense and Immune Responses in Human Female Reproductive Tract Epithelial Cells". FRONTIERS MEDIA SA, 2016. http://hdl.handle.net/10150/617371.

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IL-36 gamma is a proinflamatory cytokine which belongs to the IL-1 family of cytokines. It is expressed in the skin and by epithelial cells (ECs) lining lung and gut tissue. We used human 3-D organotypic cells, that recapitulate either in vivo human vaginal or cervical tissue, to explore the possible role of IL-36 gamma in host defense against pathogens in the human female reproductive tract (FRT). EC were exposed to compounds derived from virus or bacterial sources and induction and regulation of IL-36 gamma and its receptor was determined. Polyinosinic-polycytidylic acid (poly I:C), flagelli

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22

Govender, Thashlin. "Antifungal activity of epithelia from selected frogs species of the south Western Cape of South Africa." Thesis, Cape Peninsula University of Technology, 2008. http://hdl.handle.net/20.500.11838/1476.

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Thesis (MTech Biomedical Technology)) ---Cape Peninsula University of Technology, 2008<br>Resistance to antibiotics has been acknowledged as a major global public health problem. The use of peptides to provide alternatives to combat multi drug resistant organisms is of current relevance to overcome antibiotic resistance. The high deversity of amphibian skin peptides render these animals a potential source for the discovery of novel drugs.

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23

Liu, Youzhong. "Etude des interactions levures/bactérie par métabolomique." Thesis, Dijon, 2015. http://www.theses.fr/2015DIJOS074/document.

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Le vin en tant qu’écosystème complexe est un modèle particulièrement intéressant pour l’étudie des interactions entre les microorganismes. L’interaction sans contact celluaire (interaction indirecte) entre la levure Saccharomyces cerevisae et la bactérie lactique Oenococcus oeni a un effect direct sur l’induction et l'achèvement de la fermentation malolactique (FML), une fermentation très importante pour la qualité du vin. Une souche levurienne peut être classée FML+ si elle stimule la croissance bactérienne et FML- si elle a un effet inhibiteur. Les métabolites connus qui inhibent ou stimulen

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24

Wall, Erin A. "ELUCIDATION OF A NOVEL PATHWAY IN STAPHYLOCOCCUS AUREUS: THE ESSENTIAL SITE-SPECIFIC PROCESSING OF RIBOSOMAL PROTEIN L27." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/3747.

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Ribosomal protein L27 is a component of the eubacterial large ribosomal subunit that has been shown to play a critical role in substrate stabilization during protein synthesis. This function is mediated by the L27 N-terminus, which protrudes into the peptidyl transferase center where it interacts with both A-site and P-site tRNAs as well as with 23S rRNA. We observed that L27 in S. aureus and other Firmicutes is encoded with a short N-terminal extension that is not present in most Gram-negative organisms, and is absent from mature ribosomes. The extension contains a conserved cleavage motif; n

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25

Wynn, Jessica Elaine. "Functionalizing Branched Peptides with Unnatural Amino Acids Toward Targeting HIV-1 RRE RNA and Microbials." Diss., Virginia Tech, 2016. http://hdl.handle.net/10919/82227.

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The interaction of the protein Rev with Rev Response Element (RRE) RNA is critical to the HIV-1 life cycle as this complex is required for the export of singly-spliced and unspliced mRNAs from the nucleus to the cytoplasm. Disruption of this interaction is considered to be a powerful strategy towards the development of HIV-1 therapeutics. Therefore, we have developed several branched peptide libraries containing unnatural amino acids to target the high-affinity binding site of RRE RNA (RRE IIB), with the idea that branching in peptides can provide multivalent contacts with folded RNA structu

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26

Smith, Mark Wayne. "Characterisation and exploitation of microbial peptide transport systems." Thesis, Bangor University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.305957.

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27

Clamens, Thomas. "Etude de l'implication de l'opéron ami de Pseudomonas aeruginosa dans l'activité anti-biofilm d'une famille d'hormones humaines." Thesis, Normandie, 2018. http://www.theses.fr/2018NORMR124.

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Dans un contexte mondial d’émergence de bactéries résistantes aux antibiotiques, il est nécessaire d’explorer de nouvelles voies de recherche pour trouver de nouveaux traitements. Cet état de fait est particulièrement marqué dans le cadre d’infections chroniques associées à une colonisation des tissus par des biofilms bactériens. L’endocrinologie microbienne est un champ de recherche axé sur l’étude des mécanismes de communication inter-règnes qui peut s’établir entre des bactéries et leurs hôtes. Les molécules humaines qui permettent ce dialogue constituent de potentiels outils capables de mo

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28

Nathan, Philip Bernard. "Genetic and biochemical studies of microbial peptidase enzymes." Thesis, Nottingham Trent University, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.258545.

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29

Ghannad, Mona. "Design and Synthesis of Collagen-binding Anti-microbial Proteins." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/19981.

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The Herpes simplex virus (HSV) is a virus that commonly infects the skin, and mucous membrane of the mouth, genitalia, and the eye. HSV-1 is the strain that is most commonly associated with corneal infections, and it is the most frequent cause of corneal blindness in North America [1]. Currently no cure is available, and many limitations are characterized by the currently available synthetic antiviral drugs, which suggest the need for other potential drug alternatives and delivery strategies. Anti-microbial peptides are naturally occurring peptides that are potent killers of a broad range of m

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30

Shurtleff, Matthew J. "DESIGNING A MICROBIAL PROLYL PEPTIDASE DELIVERY SYSTEM FOR THE TREATMENT OF CELIAC DISEASE." DigitalCommons@CalPoly, 2009. https://digitalcommons.calpoly.edu/theses/160.

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Celiac disease is an autoimmune enteropathy resulting from the ingestion of gluten and gluten-like proteins from wheat, barley and rye in afflicted individuals. Indigestible gluten-derived peptides rich in proline residues are known to be responsible for eliciting the inappropriate immune response characteristic of the disease. In this investigation, surface level expression of prolyl peptidase activity by genetically engineered probiotic lactobacilli was postulated to be a possible treatment for this disease. Plasmid-based reporter vectors were constructed utilizing a novel, homology-based cl

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31

Moon, Jinyoung. "Selective accrual and dynamics of proteinaceous compounds during pedogenesis: testing source and sink selection hypotheses." Diss., Virginia Tech, 2015. http://hdl.handle.net/10919/77030.

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The emerging evidence of preferential accumulation and long residence time of proteinaceous compounds in soil are counter to the traditional view that their structure is readily broken down through microbial activity. The shift in thinking of their residence time is, however, heavily influenced by physical and chemical protections in soil, representing an important change for understanding global biogeochemical carbon and nitrogen cycling. We investigated the accumulation patterns of proteinogenic amino acids for a long term (thousands of years) related to their sources and sinks. We found cle

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32

Wheeler, Gregory Lawrence. "Plant Carnivory and the Evolution of Novelty in Sarracenia alata." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1531948732481904.

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33

Chou, Chung Jen James. "Design and screening of potential peptide modulator through the studies of iron-dependent regulator functions /." Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/8504.

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34

Telugu, Bhanu Prakash V. L. Green Jonathan A. "An analysis of aspartic peptidases expressed by trophoblasts and placenta of even-toed ungulates." Diss., Columbia, Mo. : University of Missouri--Columbia, 2008. http://hdl.handle.net/10355/7197.

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Title from PDF of title page (University of Missouri--Columbia, viewed on February 23, 2010). The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file. Dissertation advisor: Dr. Jonathan A. Green. Vita Includes bibliographical references.

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35

Diaz, Benjamin. "STUDIES RELATING PQQ BIOSYNTHESIS TO PUTATIVE PEPTIDASES AND OPERON STRUCTURE IN PSEUDOMONAS SPECIES." UKnowledge, 2017. http://uknowledge.uky.edu/pss_etds/95.

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Several bacteria isolated from the broccoli rhizosphere were assayed to compare their ability to solubilize phosphate and release pyrroloquinoline quinone (PQQ) into the surrounding media. Subsequently, their genomes were sequenced and analyzed for PQQ biosynthesis operon structure. PQQ biosynthesis genes pqqA-F were found in all isolates. The order of PQQ biosynthesis genes and predicted amino acid sequences were compared to each other and the host’s ability to solubilize phosphate and release PQQ. In all Pseudomonas species, two putative protease genes, pqqF, and pqqG, flanked the canonical

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36

Silva, Alessandra Vaso Rodrigues da. "Prospecção das interações mastoparano-membrana em proteolipossomos como modelo para o desenvolvimento racional de novos agentes antimicrobianos /." Rio Claro : [s.n.], 2009. http://hdl.handle.net/11449/87736.

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Resumo: Neste trabalho estudou-se a estrutura, função e mecanismo de ação do peptídeo antibacteriano Protonectarina-MP (isolado de veneno da vespa social Protonectarina sylveirae) tendo seu resíduo C-terminal nas formas ácida (-OH) e amidada (-NH2). Os peptídeos foram sintetizados, utilizando-se a estratégia Fmoc, purificados por cromatografia líquida de alta performance. O monitoramento do material sintético foi feito por espectrometria de massas ESI-MS e por seqüenciamento através de Química Degradativa de Edman. A estrutura secundária foi investigada pelo uso de espectroscopia de dicroísmo

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Prabhu, Saurabh. "Determining the in vitro anti-cancer effects of various novel indoles and an anti-microbial peptide towards a potential treatment of glioma." Thesis, University of Central Lancashire, 2014. http://clok.uclan.ac.uk/11323/.

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Substituted indoles (2-arylindoles) and related structures are known to exhibit potent anti-cancer activity against human breast cancer cell lines, and a range of other therapeutic targets. This activity, and other factors such as their biological activity, the fact that they are privileged structures, and the presence of the indole nucleus in various commercial anti-cancer drugs led to the choosing of indoles for the current study as a starting point for the development of new treatments against glioma. Investigation began on determining the anti-cancer activity of a variety of indoles agains

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Milhan, Noala Vicensoto Moreira. "Avaliação do peptideo LL-37 em contato com células-tronco da polpa dentária /." São José dos Campos, 2017. http://hdl.handle.net/11449/149791.

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Orientador: Samira Esteves Afonso Camargo<br>Banca: Luana Marotta Reis de Vasconcellos<br>Banca: Mônica Ghislaine Oliveira Alves<br>Banca: Cristina Pacheco Soares<br>Banca: Cacio de Moura Netto<br>Resumo: O peptídeoLL-37 (catelicidina derivada de humano), é liberado por algumas células humanas e capaz de neutralizar os tecidos com lipopolissacarídeo (LPS), além de atrair células da polpa, e induzir a angiogênese, características que o tornam um possível adjunto para a regeneração do complexo dentino-pulpar. O objetivo desse trabalho foi avaliar in vitro a biocompatibilidade do peptídeo LL-37 n

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Silva, Alessandra Vaso Rodrigues da [UNESP]. "Prospecção das interações mastoparano-membrana em proteolipossomos como modelo para o desenvolvimento racional de novos agentes antimicrobianos." Universidade Estadual Paulista (UNESP), 2009. http://hdl.handle.net/11449/87736.

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Made available in DSpace on 2014-06-11T19:22:59Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-06-08Bitstream added on 2014-06-13T20:29:34Z : No. of bitstreams: 1 silva_avr_me_rcla.pdf: 1706887 bytes, checksum: eda68ea29b93397b581e427121535611 (MD5)<br>Neste trabalho estudou-se a estrutura, função e mecanismo de ação do peptídeo antibacteriano Protonectarina-MP (isolado de veneno da vespa social Protonectarina sylveirae) tendo seu resíduo C-terminal nas formas ácida (-OH) e amidada (-NH2). Os peptídeos foram sintetizados, utilizando-se a estratégia Fmoc, purificados por cromatografia

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Masson, Florent. "Régulations immunitaires et cellulaires impliquées dans le maintien et le contrôle des bactéries endosymbiotiques du charançon des céréales du genre Sitophilus spp." Thesis, Lyon, INSA, 2015. http://www.theses.fr/2015ISAL0116/document.

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Plusieurs insectes se développant dans des milieux nutritionnellement déficients vivent en symbiose durable avec des bactéries intracellulaires (endosymbiotes) qui complémentent leur alimentation et améliorent leur pouvoir adaptatif. Alors que ces associations ont été largement étudiées sur les plans physiologiques et évolutifs, peu de travaux se sont consacrés à l’étude des mécanismes impliqués dans la tolérance et le contrôle des endosymbiotes par l’hôte. L’objectif de cette thèse est d’étudier, chez les charançons des céréales du genre Sitophilus, les particularités moléculaires et immunita

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Trino, Luciana Daniele. "Funcionalização de superfícies e estudo de adsorção de biomoléculas em óxidos metálicos." Universidade Estadual Paulista (UNESP), 2018. http://hdl.handle.net/11449/154201.

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Nelson, Geoffrey Winston. "Surface characterization and functional properties of carbon-based materials." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:f22b95ce-65f3-4d9e-ac3d-a88f6e142c1a.

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Carbon-based materials are poised to be an important class of 21st century materials, for bio-medical, bio-electronic, and bio-sensing applications. Diamond and polymers are two examples of carbon-based materials of high interest to the bio-materials community. Diamond, in its conductive form, can be used as an electrochemical bio-sensor, whilst its nanoparticle form is considered a non-inflammatory platform to deliver drugs or to grow neuronal cells. Polymers, especially when chemically modified, have been used extensively in biological environments, from anti-microbial use to drug delivery.

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Kuo, Ting-Rung, and 郭庭榕. "Identification of anti-microbial peptides and their functional types." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/2ec6u3.

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碩士<br>國立中央大學<br>資訊工程學系<br>106<br>Owing to the abuse of antibiotics, the infection resistance of microbial pathogens against chemical antibiotics increases rapidly. Antimicrobial peptides (AMPs) are essential components of the innate immune system with the lower possibility on the emergence of resistance and produced by virtually all organisms known on earth, hence become the attractive candidates for development as therapeutics. AMPs are able to resist various pathogenic microorganisms, such as viruses, parasites, bacteria, and fungi. However, little research dedicates to differentiate the mul

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Lam, Lisa Ngoc Han. "The synthesis of Staphylococcal quorum sensing-inhibiting cyclic peptides via continuous-flow solid phase peptide." Thesis, 2017. http://hdl.handle.net/1959.7/uws:45620.

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The overuse of antibiotics has imposed immense selective pressure on Staphylococcal bacteria which has resulted in the increased evolution of antibiotic-resistant bacteria such as Methicillin-resistant S. aureus to the point where last-line agents are now obsolete. Therefore, there is great pressure to develop novel approaches to combat bacterial infections while minimising the development of resistance. Here, the development of compounds which inhibit bacterial quorum sensing through antagonism of the accessory gene regulator (agr) display promise as a new generation of therapeutics. In this

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Uma, M. V. "Studies on Efrapeptins." Thesis, 1999. https://etd.iisc.ac.in/handle/2005/1536.

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Uma, M. V. "Studies on Efrapeptins." Thesis, 1999. http://etd.iisc.ernet.in/handle/2005/1536.

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Chia, Brian Cheng San. "Amphibian antimicrobial peptides : their structures and mechanisms of action / by Brian Cheng San Chia." Thesis, 2000. http://hdl.handle.net/2440/19636.

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Copy of author's previously published works inserted.<br>Bibliography: leaves 183-220.<br>xiii, 226 leaves : ill. (chiefly col.) ; 30 cm.<br>Three antimicrobial peptides, maculatin 1.1, uperin 3.6 and caerin 4.1 have been isolated from the respective skin glands of the Australian amphibians Litoria genimaculata, Uperoleia mjobergii and Litoria caerulea. To gain a deeper insight into their mechanisms of action, three dimensional structural studies have been conducted using circular dichroism, two-dimensional nuclear resonance and computer modelling techniques. The role of central flexibility wi

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Takahashi, Sumiko Logan Timothy M. "Preparation and crystallization trials of HR1 peptide bound iron-dependent repressor protein of mycobacterium tuberculosis." 2006. http://etd.lib.fsu.edu/theses/available/etd-05082006-173409.

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Thesis (M.S.)--Florida State University, 2006.<br>Advisor: Timothy M. Logan, Florida State University, College of Arts and Science, Dept. of Chemistry and Biochemistry. Title and description from dissertation home page (viewed Sept. 15, 2006). Document formatted into pages; contains xi, 63 pages. Includes bibliographical references.

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Goredema, Wadzanayi Patience. "An investigation into the proteolytic degradation of antimicrobial peptides by plant extracts and localisation of pleurocidin in transgenic saccharum hybrid species." Thesis, 2001. http://hdl.handle.net/10413/9779.

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Two cationic antimicrobial peptides, ESF I-GR7, and pleurocidin, were assessed for their stability in plant intercellular fluid, the targeted locale for their expression in transgenic plants. Incubation of ESFI-GR7 and pleurocidin with intercellular fluid (ICF) extracted from sugarcane, tomato and tobacco leaves reduced their biotoxicity towards various pathogens, namely Camobacterium mobile DMSO and Xanthomollas campestris. It was concluded that it may be necessary to modify the aminoacid structures of the peptides in order to ensure that endogenous proteases would not degrade the peptides on

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Wabnitz, Paul Andrew. "Chemistry and medical implications of novel amphibian peptides : a thesis submitted for the degree of Doctor of Philosophy / by Paul Andrew Wabnitz." Thesis, 1999. http://hdl.handle.net/2440/19494.

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Copies of author's previously published articles inserted.<br>Includes bibliographical references.<br>xv, 210 leaves : ill. ; 30 cm.<br>A chemical and pharmacological investigation of compounds derived from amphibian skin. Isolates novel amphibian peptides and further investigates the biological activity of some of the peptides discovered.<br>Thesis (Ph.D.)--University of Adelaide, Dept. of Chemistry, 2000

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