Dissertations / Theses on the topic 'Mice embryology; mice genetics'
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McClellan, Kelly Anne. "Murine oocyte loss occurs during fetal development." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=79047.
Full textIn this study the controversy was addressed by establishing a new and reliable method to quantify murine oocytes in meiotic prophase, as well as to determine the gestation age and meiotic prophase stage of oocyte loss. Earlier limitations were overcome through the use of Germ Cell Nuclear Antigen-1 (GCNA-1) antibody as a germ cell specific marker, and the novel addition of a cytospin centrifugation step to the method. Progress through meiotic prophase was examined in chromosome spread preparations where meiotic stages were assessed using an antiserum against synaptonemal complex (SC) proteins. Quantification was accomplished by counting the number of GCNA-1 immunoreactive cells in chromosome spread preparations and estimated in histological sections using the ratio estimation model. (Abstract shortened by UMI.)
Fu, Germaine 1976. "Mouse oocytes and embryos with or without the H10 gene : linker histone subtypes and development performance." Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=33399.
Full textImmunocytochemistry of wild-type cells demonstrated that H10 was predominant in oocytes while somatic H1 began accumulating in the 2-cell embryo. In H10-/- cells H10 was not detected, but, surprisingly, somatic H1 was detected beginning at the 1-cell stage. Radiolabeling of wild-type and H10-/- cells revealed that somatic H1 synthesis intensified after meiotic maturation, and therefore prior to its detection in embryos. The functional study found that loss of H10 impaired oogenesis but enhanced embryogenesis. The patterns of H1 immunodetection and synthesis are integrated, and the significance of H1 composition in development is discussed.
McLay, David W. "Developmental regulation and molecular nature of an activity in murine oocytes that transfers histones onto sperm DNA." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=38235.
Full textMacdonald, Karen Beth. "The genetics and embryopathology of exencephaly in SELH/Bc mice." Thesis, University of British Columbia, 1988. http://hdl.handle.net/2429/27983.
Full textMedicine, Faculty of
Medical Genetics, Department of
Graduate
Moase, Connie E. (Connie Evelyn). "Histopathology of, and retinoic acid effects in, biochemically identified splotch-delayed mouse embryos." Thesis, McGill University, 1986. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=66099.
Full textHurtubise, Patricia. "Intracellular signalling during murine oocyte growth." Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=31239.
Full textO'Leary, Debra Alison. "Characterisation of gene structure and function of the ETS transcription factor Gabpα in mouse." Monash University, Centre for Functional Genomics and Human Disease, 2003. http://arrow.monash.edu.au/hdl/1959.1/9445.
Full textNowacka, Lidia. "Muscle gene transfer studies of a 27-BP segment of the troponin I fast gene IRE enhancer." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111563.
Full textAlthough constructs containing the wild-type IRE 27-bp region were expressed, there was little preferential expression in fast fibers, in contrast to expression driven by the complete 148-bp IRE. Thus my results indicate that the MEF2 and CACT elements are not sufficient to drive fast fiber-type-specific expression, and suggest that additional elements outside of the 27-bp region tested are also necessary for fiber-type-specificity.
Glaser, Juliane. "Functional characterization of the imprinted Liz/Zdbf2 locus in mice : from the early embryo to adult physiology." Electronic Thesis or Diss., Sorbonne université, 2018. http://www.theses.fr/2018SORUS243.
Full textGenomic imprinting refers to the epigenetic mechanism by which approximately 120 genes are expressed in a parent-of-origin manner. This parental asymmetry in gene expression is mediated through differential profiles of DNA methylation established in the oocyte and the sperm and maintained after fertilization in the developing individual. In mammals, imprinted genes are essential for normal embryo development as well as behavioral and physiological functions after birth. Clarifying the regulation and the function of those genes is thus fundamental in the field of developmental biology and health. During my PhD, I functionally characterized the imprinted Zdbf2 locus in mice. Zdbf2 is a paternally expressed gene, conserved from mouse to human, whose biological function was unknown. I revealed that Zdbf2 activation in the post-natal brain requires an indelible epigenetic signal that is established during the first days of embryogenesis. Additionally, I provided in vivo evidence that early programming of Zdbf2 is essential for proper growth after birth. By generating multiple CRISPR-mediated genetic mutants with varied doses of Zdbf2 in the hypothalamo-pituitary axis, I finally demonstrated that Zdbf2 is a growth-promoting gene, with a dose-sensitive effect and acting independently of its parental origin. Altogether, my work shed light onto the crucial function of a mammalian imprinted gene, from its regulation in the early embryo to its role in adult physiology
Poirier, Luc. "The degradation of the stem-loop binding protein at the late 2-cell stage of mouse embryogenesis /." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=80351.
Full textMcGowan, Kelly Ann. "Genetics of skin color in mice /." May be available electronically:, 2008. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.
Full textChan, Siu-yuen. "Effects of prostaglandins on peri-implantation development of mouse embryos /." [Hong Kong : University of Hong Kong], 1989. http://sunzi.lib.hku.hk/hkuto/record.jsp?B12730191.
Full textBhanji, Tania. "Elastin in zebrafish and mice." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111938.
Full textIn the second part of this study, elastin-null mice were studied to uncover the impact of the loss of elastin on the expression of other elastic fiber-associated proteins. The expression of fibrillin-1, the major component of microfibrils, was not altered in the absence of elastin, implying that elastin is not necessary for the formation of microfibrils. On the other hand, both fibulin-2 and -5 were upregulated in the absence of elastin, suggesting that expression of these genes are controlled by elastin. Overall, this study highlights the importance of elastin in evolution, as well as its potential role in the regulation of expression of other matrix molecules.
Devine, Jill Christine. "POPULATION GENETICS OF GOLDEN MICE (OCHROTOMYS NUTTALLI) AND WHITE-FOOTED MICE (PEROMYSCUS LEUCOPUS)." OpenSIUC, 2012. https://opensiuc.lib.siu.edu/theses/943.
Full textByers, Shannon L. "Use of Inbred Strains of Mice to Study the Genetics and Biology of Sperm Function." Fogler Library, University of Maine, 2006. http://www.library.umaine.edu/theses/pdf/ByersSL2006.pdf.
Full textJoyce, Bradley. "Elucidating the molecular mechanisms underlying cell movements during early embryogenesis." Thesis, University of Oxford, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.589616.
Full textHusbands, Sandra D. "Tolerance and immunity in transgenic mice." Thesis, University College London (University of London), 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.303680.
Full textGini, Beatrice. "The genetics of family interactions in mice." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/the-genetics-of-family-interactions-in-mice(afdad740-ef76-403c-b4fc-738a3470cffe).html.
Full textFuku, Eiji. "Studies on the preservation of mammalian embryos in the supercooled state." Thesis, McGill University, 1991. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=60523.
Full textExposure for 1 h to $>$ 0.6 M of sucrose or trehalose at room temperature suppressed growth in culture, but dehydration in up to 0.4M sucrose before supercooling (in M:P) increased survival at $-$5 or $-$10$ sp circ$C, survival increasing with dehydration.
Finally, demi-embryos and intact embryos were cultured to the blastocyst stage, stored at $-$5$ sp circ$ for 48 h, then cultured for 24 h and transferred into pseudopregnant recipients.
Chia, Gloryn Le Bin. "Investigating the role of Oct4 during lineage specification in the physiological context of mouse embryonic development." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.607990.
Full textYu, Hing-Sing. "Studies on the toxicity and teratogenicity of cadmium on mouse pre-embryos in vitro and in vivo with special reference to their subsequent development /." [Hong Kong] : University of Hong Kong, 1987. http://sunzi.lib.hku.hk/hkuto/record.jsp?B1221579X.
Full textBehnam, Yousif Toma. "DNA hypomethylation and gene expression in mice." Thesis, University of Southampton, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296518.
Full textBell, Cindy Lea. "Transport studies in primary cultures of mouse renal epithelial cells." Thesis, McGill University, 1986. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=75363.
Full textIn order to determine if the defect is intrinsic to the renal cell or dependent upon an extrinsic humoral factor, I established primary cultures of renal epithelial cells from normal and Hyp mouse kidney. The cultures demonstrated several differentiated properties of epithelial cells of the renal proximal tubule, the site of the Pi transport defect in the Hyp mouse.
Primary cultures initiated from Hyp mice had decreased Pi transport (expressed as an uptake ratio, Pi/$ alpha$-MG), and increased production of 24,25 dihydroxyvitamin D$ sb3$. These results provide evidence for the intrinsic nature of the primary defect in the Hyp mouse.
This appears to be the first time that expression of a mutant transport gene has been demonstrated in cultured renal cells.
Hübner, Roland Karl Peter. "Chromosomal and biochemical variation in wild mice from Switzerland : relevance for models of chromosomal evolution in European house mice." Thesis, University of Oxford, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316879.
Full textLe, Tissier Paul Roussel. "The biochemical genetics of purine catabolism in mice." Thesis, University of Reading, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236393.
Full textRambau, Ramugondo Victor. "Molecular genetics of Rhabdomys subspecies boundaries : phylogeography of mitochondrial lineages and chromosomal fluorescence in situ hybridization." Thesis, Stellenbosch : Stellenbosch University, 2003. http://hdl.handle.net/10019.1/53504.
Full textENGLISH ABSTRACT: The geographic genetic population structure and evolutionary history of the African four-striped mouse, Rhabdomys pumilio, was investigated using mitochondrial (mtDNA) cytochrome b gene (1140 bp) and control region (994 bp) sequences and a combination of cytogenetic banding techniques (G- and C-banding), and fluorescence in situ hybridization. Two cytotypes (2n = 46 and 2n = 48) were identified by cytogenetic analysis. No evidence of diploid number variation within populations was found nor were there differences in gross chromosome morphology, or subtle interchromosomal rearrangements at levels detected by ZOO-FISH. The comparative painting data (using the complete suite, N = 20, of Mus musculus chromosome specific painting probes) show that 10 mouse chromosomes have been retained as chromosomal arms, or intact chromosome blocks within the R. pumilio genome, six produced double signals, while the remaining four hybridized to three or more R. pumilio chromosomes. In total, the 20 mouse chromosome paints detected 40 segments of conserved synteny. Their analysis revealed eight R. pumilio specific contiguous segment associations, a further two that were shared by R. pumilio and other rodents for which comparable data are available, the Black (Rattus rattus) and Norwegian (Rattus nONegicus) rats, but not by the Chinese hamster, Cricetulus grise us. The results suggest that mouse chromosomes 1, 10, and 17 have undergone extensive rearrangements during genome evolution in the murids and may be useful markers for enhancing our understanding of the mode and tempo of chromosome evolution in rodents. Following initial studies using control region sequences, the phylogeographic appraisal of R. pumilio was done using cytochrome b gene sequences. Analyses based on a variety of analytical procedures resulted in the detection of two major mtDNA lineages that correspond roughly to the xeric and mesic biotic zones of southern Africa. One clade comprises specimens with 2n = 48, and the other representatives of two cytotypes (2n = 48 and 2n = 46). The mean sequence divergence (12.0%, range 8.3% -15.6%) separating the two mtDNA clades is comparable to among-species variation within murid genera suggesting their recognition as distinct species, the prior names for which would be R. dilecfus and R. pumilio. Low sequence divergences and the diploid number dichotomy within the mesic lineage support the recognition of two subspecies corresponding to R. d. dilecfus (2n = 46) and R. d. chakae (2n = 48). The data do not support subspecific division within the nominate, R. pumilio. Molecular dating places cladogenesis of the two putative species at less than 5 million years, a period characterised by extensive climatic oscillations which are thought to have resulted in habitat fragmentation throughout much of the species' range.
AFRIKAANSE OPSOMMING: Die geografiesebevolkingsstruktuur en evolusionêre verwantskappe binne die Afrika streepmuis, Rhabdoys pumilio, is ondersoek deur middel van mitochondriale ONS volgordebepaling van die geenfragment sitochroom b (1140 basispare) en die reguleerstreek (994 bp) in kombinasie met sitogenetiese tegnieke (G- en Cbandkleuring en f1uoreseerende in situ hibridisasie). Twee sitotipes (2n = 46 en 2n = 48) is geidentifiseer deur sitogenetiese analasie. Geen bewys van variasie in die 2n chromosoomgetal binne bevolkings is gevind nie. Verder is daar ook geen verskil in die morfologies struktuur van chromosome aanwesig binne bevolkings nie. Vergelykende data (verkry met behulp van die N = 20 Mus musculus chromosoomspesifiekepeilers) dui daarop dat 10 muis chromosome behoud gebly het as chromosoomarms of chromosoomblokke binne die R. pumilio genoom. Ses peilers het dubbel seine gelewer terwyl die oorblywende vier peilers gehibridiseer het aan drie of meer R. pumilio chromosome. In totaal het die 20 muischromosoomverwe 40 konserwatiewe segmente geidentifiseer. Die analise dui agt R. pumilio spesifieke aaneenlopende segmentassosiasies aan, met 'n addisionele twee wat deur R. pumilio en ander muisagtiges vir wie vergelykende data beskikbaar is, byvoorbeeld die swart (Rattus rattus) en Noorweegse (R. norvegicus) rot maar nie die Chinese hamster, Cricetulus grise us, gedeel word. Die resultate stel voor dat muischromosoom 1, 10 en 17 ekstensiewe herrangskikkings ondergaan het gedurende die genoom evolusie binne die Muridae en dat hulle waarskynlik waardevolle merkers kan wees om beide die patroon en tempo van chromosome evolusie in muisagtiges verder te kan verstaan. Die filogeografiese verwantskappe binne R. pumilio is ondersoek deur middel van ONS volgordebepalings van die reguleerstreek asook sitochroom b. Die resultate van hierdie studie het twee divergente mitochondriale ONS eenhede ontdek wat gekorreleer kan word met xeriese en mesiese klimaatsones binne suidelike Afrika. Een groep bestaan uit diere met 2n = 48, terwyl die ander genetiese groep twee sitotipes (2n = 46 en 2n= 48) insluit. 'n Gemiddelde genetiese divergensie van 12.0% (varieer tussen 8.3% - 15.5%) verdeel die twee mtDNS-groepe en is vergelykbaar met tussenspesievariasie binne ander muisagtige genera, wat moontlik daarop dui dat twee verskillende spesies teenwoordig is; die voorgestelde name is R. di/ectus en R. pumilio. Lae genetiese divergensie binne die mesiese groep versterk die moontlike teenwoordigheid van twee subspesies, R. d. di/ectus (2n = 46) en R. d. chakae (2n = 48). Die data verleen egter nie steun aan die divisie binne R. pumilio nie. Molekulêre datering van die twee spesies dui daarop dat die divergensie ten minste 5 miljoen jaar gelede plaasgevind het. Die periode was gekarakteriseer deur ekstensiewe klimaatsossilasies, wat gely het tot habitat fragmentasie in die spesie se verspreidingsgebied.
Cheong, Wan-yee Ana, and 張韻怡. "A study on the embryotrophic action of the complement component-3 derivative (iC3b) in the preimplantation mouse embryo development." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B44231994.
Full textFung, Chun-kit. "An investigation on the effects of glutamine in culture meida on the preimplantation mouse embryo /." Hong Kong : University of Hong Kong, 1999. http://sunzi.lib.hku.hk/hkuto/record.jsp?B21629821.
Full textAhmed, F. A. W. "Pleiotropic effects of coat-colour mutants in mice." Thesis, University of Essex, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375647.
Full textAsante, Emmanuel A. "Biochemical genetics of lipid metabolism in chickens and mice." Thesis, University of Edinburgh, 1988. http://hdl.handle.net/1842/11520.
Full textTinch, Alan E. "The genetics of muscle growth in chickens and mice." Thesis, University of Edinburgh, 1990. http://hdl.handle.net/1842/13134.
Full textMao, Jian-Hua. "Stochastic modelling of tumorigenesis in p53 deficient transgenic mice." Thesis, University of Glasgow, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286124.
Full textArgyropoulos, George. "Molecular and genetic investigations of testicular development in mice." Thesis, University of Essex, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.280829.
Full textTian, Xiao Ying. "The study of Chinese herbal medicine in embryonic development of mice." HKBU Institutional Repository, 2009. http://repository.hkbu.edu.hk/etd_ra/1071.
Full textKim, Iksoo Phillips Carleton J. "Gene flow, genetic population structure, and biogeography of the leaf-eared mouse, Phyllotis xanthopygus, dwelling in natural habitat islands." Normal, Ill. Illinois State University, 1998. http://wwwlib.umi.com/cr/ilstu/fullcit?p9835913.
Full textTitle from title page screen, viewed July 5, 2006. Dissertation Committee: Carleton J. Phillips (chair), Elmer C. Birney, Angelo P. Capparella, Sabine S. Loew, Charles F. Thompson. Includes bibliographical references (leaves 61-74) and abstract. Also available in print.
Jeffries, Sean Joseph. "Imprint erasure and DNA demethylation in mouse development." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608949.
Full textBander, S. A. A. "Pre-zygotic interactions in mice : A genetic analysis." Thesis, University of Essex, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.380568.
Full textShukri, N. M. "Genetic studies of male reproductive characteristics in mice." Thesis, University of Essex, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383426.
Full textChan, Siu-yuen, and 陳小圓. "Effects of prostaglandins on peri-implantation development of mouse embryos." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1989. http://hub.hku.hk/bib/B30257256.
Full textFung, Chun-kit, and 馮俊傑. "An investigation on the effects of glutamine in culture meida on the preimplantation mouse embryo." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B31222560.
Full text余慶聲 and Hing-Sing Yu. "Studies on the toxicity and teratogenicity of cadmium on mouse pre-embryos in vitro and in vivo with special reference to theirsubsequent development." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1987. http://hub.hku.hk/bib/B31231457.
Full textAlexandrova, Stoyana. "In vivo behaviour of embryonic stem cells in early mouse embryo development." Thesis, University of Cambridge, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708686.
Full textCaron, Judith 1973. "Genetics of host resistance to chronic Salmonella infection in mice." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=85895.
Full textThe contribution of genes controlling the late phase of a Salmonella infection was studied using a model based on the inoculation of a sublethal dose of S. Enteritidis in 129S6 and C57BL/6J mice. C57BL/6J mice were able to eliminate completely S. Enteritidis from their RES, whereas 129S6 mice could not. Linkage analysis of 302 (C57BL/6J X 129S6) F2 progeny identified three QTLs, Ses1, Ses2, and Ses3. They were associated with disease susceptibility in 129S6 mice, and their estimated effects on bacterial clearance were greater in females. A statistical interaction was detected between Ses1 and Ses2. The model included the QTLs, the interaction and sex as a covariate, and explained 32% of the phenotypic variance suggesting that unidentified modifiers contributed to the phenotype.
A two-locus epistasis QTL linkage analysis conducted separately in the F2 females and males identified additional QTLs with individual effects and epistasic QTLs associated with the Salmonella carrier state of 129S6 mice. The model for females included Ses3 and two significant interactions (Ses1-D7Mit267 and Ses1-DXMit48 ) accounting for 47% of the total phenotypic variance. The model for males included Ses1.1, three interactions (Ses1-D9Mit218, D2Mit197-D4Mit2 and D3Mit256-D13Mit36) and explained 47% of the phenotypic variance.
We constructed congenic mice carrying the Ses1.1, Ses1, Ses2 and Ses3 regions to validate their existence in vivo and to study their impact on Salmonella clearance (129.136). Double congenic mice Ses1/Ses2 were constructed to test functionally the statistical interaction between these QTLs. Phenotypic analysis confirmed that Ses1 and Ses1.1 contribute to bacterial clearance.
The candidacy of Nramp1 as the gene underlying Ses1 was evaluated using Nramp1-deficient mice. 129S6-Nramp1tm1Mcg mice have a significantly lower bacterial load compared to 129S6 mice, suggesting that Nramp1 influences the S. Enteritidis clearance during the late phase of infection. We observed that the 129S6 mice mounted an early and strong TH1 response, whereas the 129S6-Nramp1 tm1Mcg mice mounted an earlier and more vigorous TH 2 response that seems to improve the late phase Salmonella clearance.
Everett, Clare Alexandra. "Robertsonian translocations and their effect on the fertility of mice." Thesis, University of Oxford, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.357568.
Full textChau, Hien Nguyet 1977. "Renal calcification in Npt2 knockout mice." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=78338.
Full textSalcedo, Tovah. "Population Genetics and Evolution of Innate Immunity in House Mice." Diss., The University of Arizona, 2009. http://hdl.handle.net/10150/194535.
Full textYazbek, Soha Nabil. "Analysis of genetic susceptibility to type II diabetes in mice." Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1277326732.
Full textHolmes, Andrew. "Mechanisms and contexts of kin recognition in female house mice." Thesis, University of Liverpool, 2012. http://livrepository.liverpool.ac.uk/9259/.
Full textSchmidt, Kristie. "The Mechanism of Obesity in Rai1+/- Mice." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/135.
Full textMoase, Connie E. (Connie Evelyn). "Cell interactions in abnormal neural tube and neural crest cell development of splotch mice." Thesis, McGill University, 1991. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=70336.
Full text