Relevant bibliographies by topics / Mice Color

Academic literature on the topic 'Mice Color'

Author: Grafiati
Published: 10 December 2022
Last updated: 28 January 2023

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Journal articles on the topic "Mice Color"

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Davis, Andrew K., Natalie Woodall, Jake P. Moskowitz, Nikole Castleberry, and Byron J. Freeman. "Temporal Change in Fur Color in Museum Specimens of Mammals: Reddish-Brown Species Get Redder with Storage Time." International Journal of Zoology 2013 (2013): 1–6. http://dx.doi.org/10.1155/2013/876347.

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Museum collections have great value for zoological research, but despite careful preservation, over time specimens can show subtle changes in color. We examined the effect of storage time on fur color of two reddish-brown species, golden mice (Ochrotomys nuttalli) and eastern chipmunk (Tamias striatus). Using image analysis, we obtained color data (hue, saturation, and density) on 91 golden mice and 49 chipmunks from Georgia, USA. Analyses that considered body size, gender, and collection year showed significant effects of year on fur color of golden mice (hue and saturation) and of agouti color of chipmunks. Older specimens tended to be redder in color than newer specimens, consistent with a prior study of red bats (Lasiurus borealis). Hair samples showed reddening of fine body hairs, but not in thicker guard hairs. There was no temporal change in black or white stripe color in chipmunks, indicating that this temporal effect would be limited to species with reddish-brown fur. This effect may be caused by breakdown of eumelanin pigments (which make dark colors) over time, leaving a greater proportion of pheomelanin pigments (which make red colors). These results show that storage time needs to be considered in research projects where fur color is of importance.
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Nitezki, Tina, Nadja Schulz, and Stephanie Krämer. "Color matters: They would choose if they could (see)!" Laboratory Animals 52, no. 6 (April 8, 2018): 611–20. http://dx.doi.org/10.1177/0023677218766370.

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Concerning standardization of laboratory animal husbandry, only exiguous changes of habitat can potentially influence animal physiology or results of behavioral tests. Routinely, mice chow is dyed when different types of diets are dispensed. Given the fact that the dye itself has no effects on food odor or flavor, we wanted to test the hypothesis that the color of chow has an impact on food uptake in mice. Twelve-week-old male mice of different strains (C57BL/6J, DBA/2J, C3H/HeJ, BALB/cJ; n = 12/strain) were single-housed in PhenoMaster® cages. After acclimatization standard mice chow in different colors was administered. Food intake was monitored as a two-alternative choice test of different color combinations. All animals had an average food intake of 3 g/d and no preferences were observed when a combination of identically colored food was offered. Preference tests yielded significant aversion to blue food and significant attraction to yellow and green food in C57BL/6 and DBA/2J mice. In C3H/HeJ and BALB/cJ mice no color-related pattern occurred. Selected mice strains have known differences concerning functionality of their visual sense. C57BL/6 and DBA/2 mice are considered to be normal sighted at testing age, BALB/c is representative for albino strains and C3H mice carry mutations resulting in retinal alterations. Results suggesting that normal-sighted mice would be selective concerning food color when given the choice. Nevertheless, this does not influence overall quantity of food intake when animals were provided solely with food colored with a single dye. Moreover, visually impaired mice showed no color-related food preferences.
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Sylvester, Francisco A., and Anne Marie Griffiths. "ENDOTHELINS AND THE COLOR OF MICE." Journal of Pediatric Gastroenterology and Nutrition 21, no. 4 (November 1995): 478. http://dx.doi.org/10.1097/00005176-199511000-00020.

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Conway, Bevil R. "Color Vision: Mice See Hue Too." Current Biology 17, no. 12 (June 2007): R457—R460. http://dx.doi.org/10.1016/j.cub.2007.04.017.

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Hoffman, Robert M., and Meng Yang. "Dual-color, whole-body imaging in mice." Nature Biotechnology 23, no. 7 (July 1, 2005): 790. http://dx.doi.org/10.1038/nbt0705-790.

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Neitz, M., and J. Neitz. "Curing Color Blindness--Mice and Nonhuman Primates." Cold Spring Harbor Perspectives in Medicine 4, no. 11 (August 21, 2014): a017418. http://dx.doi.org/10.1101/cshperspect.a017418.

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Galus, Ryszard, Krzysztof Włodarski, Jacek Malejczyk, and Jarosław Jóźwiak. "Fluvastatin Influences Hair Color in C57Bl/6 Mice." International Journal of Molecular Sciences 14, no. 7 (July 10, 2013): 14333–45. http://dx.doi.org/10.3390/ijms140714333.

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Bennett, Dorothy C., and M. Lynn Lamoreux. "The Color Loci of Mice - A Genetic Century." Pigment Cell Research 16, no. 4 (August 2003): 333–44. http://dx.doi.org/10.1034/j.1600-0749.2003.00067.x.

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ABDEL-RAHIM, Emam, Hossam S. EL-BELTAGI, Rehab F. M. ALI, Abeer A. AMER, and Somia M. MOUSA. "The Effects of Using Synthetic and Natural Color Foods on Lipid Profile and Liver Function in Rats." Notulae Scientia Biologicae 11, no. 4 (December 24, 2019): 363–67. http://dx.doi.org/10.15835/nsb11410504.

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Today synthetic food dyes are being used most commonly as food colorant in confectionaries for children. Present study was designed to evaluate effect of tartrazine and chocolate brown as a synthetic color and turmeric, cocoa as a natural color on Swiss albino mice. The rats have been fed on color biscuits and after the acclimation period, rats were divided into 7 groups (5 rats each one). Rats treated with dose level 7.5 mg/kg /day (ADI) in tartrazine and turmeric and 0.15 mg/kg /day (ADI) in chocolate brown and cocoa. The study revealed a highly noticeable decrease in the body weight gain, food intake and feed efficiency in synthetic color of mice compared to the control group, the mixture improvement this effects and non-significant with natural color. A significant increase in the average weight of the major organs liver, spleen, heart, pancreas and kidney of the mice has been increased significantly in synthetic color treated groups with tartrazine and chocolate brown. Total cholesterol level, T-lipid, LDL and vLDL were no significant change in all mice administration color foods, but significant increase in T.G with tartrazine and chocolate brown and has significant decrease in HDL-C with tartrazine and chocolate brown. There was a significant increase in the level of ALT, AST and ALP with tartrazine and chocolate brown while compared to control group. The mixture synthetic and natural color improved the results. Bilirubin levels were significantly increased with tartrazine and chocolate brown.
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Moore, K. J., D. A. Swing, E. M. Rinchik, M. L. Mucenski, A. M. Buchberg, N. G. Copeland, and N. A. Jenkins. "The murine dilute suppressor gene dsu suppresses the coat-color phenotype of three pigment mutations that alter melanocyte morphology, d, ash and ln." Genetics 119, no. 4 (August 1, 1988): 933–41. http://dx.doi.org/10.1093/genetics/119.4.933.

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Abstract The murine dilute suppressor gene, dsu, was identified because of its ability to suppress the dilute coat color of mice homozygous for the retrovirally induced allele (dv) of the dilute locus (d). dsu is unlinked to the d locus and has recently been shown to be semidominantly inherited. The dilute phenotype of d/d mice is the consequence of abnormal melanocyte morphology. While wild-type melanocytes are dendritic, d/d melanocytes are adendritic. dsu apparently suppresses the dilute phenotype by restoring normal melanocyte morphology. In addition to d, two other loci, ashen (ash) and leaden (ln), have been identified that produce a diluted coat color associated with adendritic melanocytes. Interestingly, d and ash are closely linked on chromosome 9 while dsu and ln are located on chromosome 1. In experiments described here, we present genetic mapping data between ash and d indicating that, despite their identical phenotypes, they are separate genes and are not intragenic complementing alleles of the same locus. We also show that dsu is only loosely linked to ln (approximately 9 cM proximal) and that dsu can suppress, at least partially, the coat color of ln/ln mice and ash/ash mice. The partial suppression of ln and ash coat colors is associated with the partial restoration of normal melanocyte morphology. These studies provide new insights into the mechanism of action of dsu and into the interrelationships between members of a family of pigment genes.
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Dissertations / Theses on the topic "Mice Color"

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McGowan, Kelly Ann. "Genetics of skin color in mice /." May be available electronically:, 2008. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.

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Ruivenkamp, Claudia Antoinette Laetitia. "Colon cancer susceptibility genes in mice and humans." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2003. http://dare.uva.nl/document/67685.

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Ahmed, F. A. W. "Pleiotropic effects of coat-colour mutants in mice." Thesis, University of Essex, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375647.

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Miyamoto, Shingo. "Suppressive effects of flavonoids on hyperleptinemia and colon carcinogenesis in mice." Kyoto University, 2009. http://hdl.handle.net/2433/126529.

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Kyoto University (京都大学)
0048
新制・課程博士
博士(農学)
甲第14843号
農博第1783号
新制||農||974(附属図書館)
学位論文||H21||N4483(農学部図書室)
27249
UT51-2009-F485
京都大学大学院農学研究科食品生物科学専攻
(主査)教授 入江 一浩, 教授 伏木 亨, 教授 河田 照雄
学位規則第4条第1項該当
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Richter, Cornelia, San Juan Martina Herrero, Benno Weigmann, Dominik Bergis, Katrin Dauber, Michael H. Muder, Gustavo B. Baretton, et al. "Defective IL-23/IL-17 Axis Protects p47phox−/− Mice from Colon Cancer." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-226852.

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In the colon, a sophisticated balance between immune reaction and tolerance is absolutely required. Dysfunction may lead to pathologic phenotypes ranging from chronic inflammatory processes to cancer development. Two prominent modulators of colon inflammation are represented by the closely related cytokines interleukin (IL)-12 and IL-23, which initiate adaptive Th1 and Th17 immune responses, respectively. In this study, we investigated the impact of the NADPH oxidase protein p47phox, which negatively regulates IL-12 in dendritic cells, on colon cancer development in a colitis-associated colon cancer model. Initially, we found that IL-12−/− mice developed less severe colitis but are highly susceptible to colon cancer. By contrast, p47phox−/− mice showed lower tumor scores and fewer high grade tumors than wild-type (WT) littermates. Treatment with toll-like receptor 9 ligand CpG2216 significantly enhanced colitis in p47phox−/− mice, whereas tumor growth was simultaneously reduced. In tumor tissue of p47phox−/− mice, the IL-23/IL-17 axis was crucially hampered. IL-23p19 protein expression in tumor tissue correlated with tumor stage. Reconstitution of WT mice with IL-23p19−/− bone marrow protected these mice from colon cancer, whereas transplantation of WT hematopoiesis into IL-23p19−/− mice increased the susceptibility to tumor growth. Our study strengthens the divergent role of IL-12 and IL-23 in colon cancer development. With the characterization of p47phox as a novel modulator of both cytokines our investigation introduces a promising new target for antitumor strategies.
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Gillen, Aric. "The Effects of Electrochemical Therapy on Colon-25 Tumors in Balb-C Mice." Thesis, University of North Texas, 2000. https://digital.library.unt.edu/ark:/67531/metadc2720/.

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The purpose of the research was to treat immunodeficient mice, implanted with colon-25 tumors, with continuous and interrupted electrochemical therapy (ECT). ECT involves the placement of two electrodes, an anode near the center of the tumor and a cathode into the tumor periphery. A constant voltage is applied across the electrodes for a given period of time. The data showed that the interrupted and continuous ECT resulted in a decrease in mean tumor growth as compared to that of the sham controls. The histology of both ECT groups showed an increase presence of large vacuoles, randomly distributed tumor cells as well as the presence of "crevicing" in the medullary tissue. The differential leukocyte counts showed a distinct neutrophilia and lymphopenia in all groups at day 20 post tumor implantation. The results from the experimental groups appeared to support the findings of previous investigators.
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O'Connor, Christiane C. "The influence of lipids on the growth, development, and metastatic potential of transplantable colon tumor CT-26 in Balb/c mice." Thesis, Boston University, 1987. https://hdl.handle.net/2144/38089.

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Thesis (M.A.)--Boston University
PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.
Evidence that dietary fats influence carcinogenesis comes from both epidemiological and experimental data. Previous experimental studies suggest that dietary fat acts as a promoter in chemically induced carcinogenesis and this effect depends on the degree of saturation and concentration of dietary fat. [TRUNCATED]
2031-01-01
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Edwards, Cheri Paris. "Your Blues Ain't Like Mine: Voices from the Other Side of the Color Line." Thesis, University of North Texas, 2019. https://digital.library.unt.edu/ark:/67531/metadc1609132/.

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This dissertation examines intra-racial colorism in works by writers who began their careers during the Harlem Renaissance, but whose writings span almost a century. In these writings, colorism; which can be defined as a bias directed toward an individual that is based on skin tone, is portrayed an intra-racial practice that results from the internalization of racist ideals. The practice relies on a hierarchy that most often privileges those closest to the color line. However, these depictions also show that the preponderance of skin tones can sometimes determine who is targeted. For the purposes of this study it is called reverse colorism when the bias is directed by individuals darker in skin tone toward those who are lighter. Consequently, the careful descriptions of the shades and hues of black characters becomes more than aesthetics and can be seen as a coded reference to experiential differences. While Alain Locke hailed the start of the Harlem Renaissance to signal the rise of The New Negro, the writings featured by female writers in this dissertation advance a less optimistic reality for women, who had to contend with both inter- and intra-racial bias because of their skin tone. Colorism is identified as a particularly prevalent presence in the lives of black women, who also saw skin tone subjectively and viewed themselves as darker than their male counterparts.
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Hayashi, Adam. "Effects of Daily Oral Injections of Quercetin on Implanted Colon-25 Tumor Growth in Balb-C Mice." Thesis, University of North Texas, 2000. https://digital.library.unt.edu/ark:/67531/metadc2525/.

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The effects of three oral dosages (0.4 mg, 0.8 mg, and 1.6 mg) of quercetin on Colon-25 tumors implanted in Balb-c mice were studied. The data in this study show that: (1) certain dosages of quercetin in alcohol solutions, reduces the weight, and size of implanted Colon-25 tumors in Balb-c mice, (2) these same dosages of quercetin all produce a profound neutrophilia combined with a significant lymphopenia at day 20 post-implantation, and (3) there was relatively little evidence of histological changes in the quercetin-treated tumor section which would indicate that the action(s) of quercetin is primarily at the subcellular level probably within the nuclei of the tumor cells.
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廖兆霖 and Shiu-lam Edgar Liu. "Pathogenic mechanisms of cigarette smoking on ulcerative colitis-associated neoplasia in mice." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B3124452X.

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Books on the topic "Mice Color"

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Walsh, Ellen Stoll. Mouse paint. New York: Trumpet Club, 1989.

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Frith, C. H. A color atlas of hematopoietic pathology of mice. Little Rock, AR: Toxicology Pathology Associates, 1985.

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Tomiko, Nagi, ed. Meishī-chan no nijiiro no yume. Tōkyō: Ksidridhs, 2003.

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Bernd, Schmidt. Our friend the painter. Ada, Okla: Garrett Educational Corp., 1989.

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Félix, Monique. The colors. Mankato, MN: Creative Editions, 2013.

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The colors. Mankato, Minn: Creative Education, 1991.

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Maisy's rainbow dream. Cambridge, Mass: Candlewick Press, 2003.

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Cousins, Lucy. Maisy's colors. 2nd ed. Cambridge, MA: Candlewick Press, 1999.

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Cyndy Szekeres' I love my busy book. New York: Scholastic, 1997.

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Cousins, Lucy. Pina e i colori. Milano: Mondadori, 1998.

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Book chapters on the topic "Mice Color"

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Hoffman, Robert M. "Transgenic Nude Mice Ubiquitously Expressing Fluorescent Proteins for Color-Coded Imaging of the Tumor Microenvironment." In Methods in Molecular Biology, 353–65. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-1215-5_20.

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Hardy, R. R., J. D. Kemp, and K. Hayakawa. "Analysis of Lymphoid Population in Scid Mice; Detection of a Potential B Lymphocyte Progenitor Population Present at Normal Levels in Scid Mice by Three Color Flow Cytometry With B220 and S7." In Current Topics in Microbiology and Immunology, 19–25. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74974-2_3.

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Hempelmann, Uwe. "3. Mie theory." In Colour Technology of Coatings, 143–49. Hannover, Germany: Vincentz Network, 2019. http://dx.doi.org/10.1515/9783748600282-019.

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Lockwood, David J. "Rayleigh and Mie Scattering." In Encyclopedia of Color Science and Technology, 1–12. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-27851-8_218-1.

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Lockwood, David J. "Rayleigh and Mie Scattering." In Encyclopedia of Color Science and Technology, 1–12. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-642-27851-8_218-2.

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Lockwood, David J. "Rayleigh and Mie Scattering." In Encyclopedia of Color Science and Technology, 1–12. Berlin, Heidelberg: Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-642-27851-8_218-3.

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Lockwood, David J. "Rayleigh and Mie Scattering." In Encyclopedia of Color Science and Technology, 1097–107. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4419-8071-7_218.

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Yoshida, Kazuhiko, Tohru Fujikawa, Akihiko Tanabe, and Kenji Sakurai. "Metastases Models of Human Colon Cancer in Congenitally Athymic Mice." In Recent Advances in Management of Digestive Cancers, 740–42. Tokyo: Springer Japan, 1993. http://dx.doi.org/10.1007/978-4-431-68252-3_223.

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Fleiszer, D., J. Hilgers, and E. Skamene. "Multigenic Control of Colon Carcinogenesis in Mice Treated with 1,2-Dimethylhydrazine." In Genetics of Immunological Diseases, 243–49. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-50059-6_37.

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Zhong, Sheng Wen, Qian Zhang, Shu Jing Zhang, De Qiang Han, and Jing Zhong Kuang. "Preparation of Yellow Color Pearlescent Pigments of CeO2-Mica." In Key Engineering Materials, 2549–51. Stafa: Trans Tech Publications Ltd., 2007. http://dx.doi.org/10.4028/0-87849-410-3.2549.

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Conference papers on the topic "Mice Color"

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Dos Santos, Dalí, Adriano Silva, Paulo De Faria, Bruno Travençolo, and Marcelo Do Nascimento. "Impacts of Color Space Transformations on Dysplastic Nuclei Segmentation Using CNN." In Workshop de Visão Computacional. Sociedade Brasileira de Computação - SBC, 2020. http://dx.doi.org/10.5753/wvc.2020.13475.

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Oral epithelial dysplasia is a common precancerous lesion type that can be graded as mild, moderate and severe. Although not all oral epithelial dysplasia become cancer over time, this premalignant condition has a significant rate of progressing to cancer and the early treatment has been shown to be considerably more successful. The diagnosis and distinctions between mild, moderate, and severe grades are made by pathologists through a complex and time-consuming process where some cytological features, including nuclear shape, are analysed. The use of computer-aided diagnosis can be applied as a tool to aid and enhance the pathologist decisions. Recently, deep learning based methods are earning more and more attention and have been successfully applied to nuclei segmentation problems in several scenarios. In this paper, we evaluated the impact of different color spaces transformations for automated nuclei segmentation on histological images of oral dysplastic tissues using fully convolutional neural networks (CNN). The CNN were trained using different color spaces from a dataset of tongue images from mice diagnosed with oral epithelial dysplasia. The CIE L*a*b* color space transformation achieved the best averaged accuracy over all analyzed color space configurations (88.2%). The results show that the chrominance information, or the color values, does not play the most significant role for nuclei segmentation purpose on a mice tongue histopathological images dataset.
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Garofalakis, Anikitos, Giannis Zacharakis, Heiko Meyer, Stelios Psycharakis, Clio Mamalaki, Georgia Fousteri, Joseph Papamatheakis, et al. "Two-color in-vivo imaging of fluorescent cells in mice." In Biomedical Topical Meeting. Washington, D.C.: OSA, 2006. http://dx.doi.org/10.1364/bio.2006.tuc5.

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Zacharakis, Giannis, Rosy Favicchio, Anikitos Garofalakis, Stylianos Psycharakis, Clio Mamalaki, and Jorge Ripoll. "Spectral unmixing of multi-color tissue specific in vivo fluorescence in mice." In European Conference on Biomedical Optics. Washington, D.C.: OSA, 2007. http://dx.doi.org/10.1364/ecbo.2007.6626_8.

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Zacharakis, Giannis, Rosy Favicchio, Anikitos Garofalakis, Stylianos Psycharakis, Clio Mamalaki, and Jorge Ripoll. "Spectral unmixing of multi-color tissue specific in vivo fluorescence in mice." In European Conference on Biomedical Optics, edited by Kai Licha and Vasilis Ntziachristos. SPIE, 2007. http://dx.doi.org/10.1117/12.728410.

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Uehara, Fuminari, Yasunori Tome, Hiroki Maehara, Kazuhiro Tanaka, Fuminori Kanaya, Shinji Miwa, Yukihiko Hiroshima, et al. "Abstract 13: Color-coded imaging of vessel anastomosisin vivousing RFP and CFP transgenic mice." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-13.

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Hoffman, Robert M. "Multi-color fluorescence imaging of sub-cellular dynamics of cancer cells in live mice." In Biomedical Optics 2006, edited by Alexander P. Savitsky and Rebekka Wachter. SPIE, 2006. http://dx.doi.org/10.1117/12.644923.

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Yao, Yue, Yuanhuan Zhu, Yang Dong, and Hui Ma. "Multi-color backscattering Mueller matrix imaging on thick fresh tissues and on living nude mice skin." In Dynamics and Fluctuations in Biomedical Photonics XV, edited by Valery V. Tuchin, Kirill V. Larin, Martin J. Leahy, and Ruikang K. Wang. SPIE, 2018. http://dx.doi.org/10.1117/12.2289611.

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Shen, Che-Chou, Jyun-Gong Yu, and Gency Jeng. "Implementation and evaluation of slow-time golay decoding for pre-clinical high-frequency color doppler imaging in mice." In 2015 IEEE International Ultrasonics Symposium (IUS). IEEE, 2015. http://dx.doi.org/10.1109/ultsym.2015.0330.

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Forero-Vargas, Manuel G., Eduard L. Sierra-Ballen, Wilman H. Sanchez-Rodriguez, Fredy Tejedor-Orduz, Karen Hernandez, Ana Vinasco, Eduardo Low, and Angel Bernal. "Using equalization in YIQ color model and curve adjust by splines for morphometric evaluation of histological slides in mice." In International Symposium on Optical Science and Technology, edited by Andrew G. Tescher. SPIE, 2002. http://dx.doi.org/10.1117/12.452381.

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West, Jennifer L. "Near Infrared Absorbing Nanoparticles for Photothermal Cancer Therapy." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-192982.

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Advances in nanotechnology are expected to lead to the development of new and improved therapeutic strategies, amenable to targeting, that may ultimately revolutionize cancer treatment. For example, we have developed a nanoparticle-based photothermal cancer therapy that has shown high efficacy with virtually no damage to normal tissues (Hirsch et al., 2003, O’Neal et al., 2004, Lowery et al., 2006). This therapeutic strategy employs nanoparticles called nanoshells that are designed to strongly absorb near infrared (NIR) light. Metal nanoshells are a new type of nanoparticle composed of a dielectric (for instance, silica) core coated with an ultrathin metallic (for instance, gold) layer. Gold nanoshells possess physical properties similar to gold colloid, in particular, a strong optical absorption due to the collective electronic response of the metal to light. The optical absorption of gold colloid yields a brilliant red color that has been of considerable utility in consumer-related medical products, such as home pregnancy tests. In contrast, the optical response of gold nanoshells depends dramatically on the relative size of the nanoparticle core and the thickness of the gold shell. By varying the relative core and shell thicknesses, the color of gold nanoshells can be varied across a broad range of the optical spectrum that spans the visible and the near infrared spectral regions (Oldenburg et al., 1999). Gold nanoshells can be made to either preferentially absorb or scatter light at their plasmon resonance by varying the size of the particle relative to the wavelength of the light at their optical resonance. For cancer therapy, nanoshells are injected intravenously and allowed to accumulate in tumor sites due to the leakiness of the vasculature (EPR) and/or molecular targeting. Accumulation in the tumor sites peaks after several hours, at which time the tissue region is illuminated with NIR light for several minutes. NIR light is not absorbed to a significant extent by tissue components, but is strongly absorbed by nanoshells within the tumor. This leads to rapid heating of the tumor tissue without damage to adjacent normal tissues. In preliminary studies, complete tumor regression and 100% survival with no regrowth has been achieved. Mice with CT26 colon carcinoma tumors (4 mm diameter) were injected intravenously with NIR absorbing nanoshells that were coated with PEG-SH. 6 hr following nanoshell injection, the tumor sites were illuminated with light from a 820 nm diode laser (4 W/cm2) for 4 min. Animals in a sham group received a saline injection instead of nanoshells prior to NIR treatment, while a control group was untreated. Tumor size and animal survival were then tracked. As shown in Figure 1, all tumors treated with nanoshells had completely regressed within 10 days of treatment, while sham and control tumors had grown dramatically. Furthermore, all sham and control animals died within 20 days of treatment, while all nanoshell-treated mice continue to live (+12 months) with no tumor regrowth (Figure 2, O’Neal et al., 2004). Excellent nanoshell biocompatibility has been observed.
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