Relevant bibliographies by topics / Mice – Aging; Periodontal ligament – Aging

Academic literature on the topic 'Mice – Aging; Periodontal ligament – Aging'

Author: Grafiati
Published: 10 December 2022
Last updated: 29 January 2023

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Journal articles on the topic "Mice – Aging; Periodontal ligament – Aging"

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Foster, B. L., Y. Soenjaya, F. H. Nociti, E. Holm, P. M. Zerfas, H. F. Wimer, D. W. Holdsworth, et al. "Deficiency in Acellular Cementum and Periodontal Attachment in Bsp Null Mice." Journal of Dental Research 92, no. 2 (November 26, 2012): 166–72. http://dx.doi.org/10.1177/0022034512469026.

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Bone sialoprotein (BSP) is an extracellular matrix protein found in mineralized tissues of the skeleton and dentition. BSP is multifunctional, affecting cell attachment and signaling through an RGD integrin-binding region, and acting as a positive regulator for mineral precipitation by nucleating hydroxyapatite crystals. BSP is present in cementum, the hard tissue covering the tooth root that anchors periodontal ligament (PDL) attachment. To test our hypothesis that BSP plays an important role in cementogenesis, we analyzed tooth development in a Bsp null (-/-) mouse model. Developmental analysis by histology, histochemistry, and SEM revealed a significant reduction in acellular cementum formation on Bsp-/- mouse molar and incisor roots, and the cementum deposited appeared hypomineralized. Structural defects in cementum-PDL interfaces in Bsp-/- mice caused PDL detachment, likely contributing to the high incidence of incisor malocclusion. Loss of BSP caused progressively disorganized PDL and significantly increased epithelial down-growth with aging. Bsp-/- mice displayed extensive root and alveolar bone resorption, mediated by increased RANKL and the presence of osteoclasts. Results collected here suggest that BSP plays a non-redundant role in acellular cementum formation, likely involved in initiating mineralization on the root surface. Through its importance to cementum integrity, BSP is essential for periodontal function.
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Kim, Yu Gyung, Sang Min Lee, Sungeun Bae, Taejun Park, Hyeonjin Kim, Yujeong Jang, Keonwoo Moon, et al. "Effect of Aging on Homeostasis in the Soft Tissue of the Periodontium: A Narrative Review." Journal of Personalized Medicine 11, no. 1 (January 18, 2021): 58. http://dx.doi.org/10.3390/jpm11010058.

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Aging is characterized by a progressive decline or loss of physiological functions, leading to increased susceptibility to disease or death. Several aging hallmarks, including genomic instability, cellular senescence, and mitochondrial dysfunction, have been suggested, which often lead to the numerous aging disorders. The periodontium, a complex structure surrounding and supporting the teeth, is composed of the gingiva, periodontal ligament, cementum, and alveolar bone. Supportive and protective roles of the periodontium are very critical to sustain life, but the periodontium undergoes morphological and physiological changes with age. In this review, we summarize the current knowledge of molecular and cellular physiological changes in the periodontium, by focusing on soft tissues including gingiva and periodontal ligament.
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Benatti, Bruno Braga, Karina Gonzales Silvério, Márcio Zaffalon Casati, Enilson Antônio Sallum, and Francisco Humberto Nociti. "Influence of Aging on Biological Properties of Periodontal Ligament Cells." Connective Tissue Research 49, no. 6 (January 2008): 401–8. http://dx.doi.org/10.1080/03008200802171159.

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Moxham, B. J., and I. L. Evans. "The Effects of Aging upon the Connective Tissues of the Periodontal Ligament." Connective Tissue Research 33, no. 1-3 (January 1995): 31–35. http://dx.doi.org/10.3109/03008209509016978.

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Zanoni, Jacqueline N., Nathalia M. Lucas, Aline R. Trevizan, and Ivan D. S. Souza. "Histological evaluation of the periodontal ligament from aged wistar rats supplemented with ascorbic acid." Anais da Academia Brasileira de Ciências 85, no. 1 (March 1, 2013): 327–35. http://dx.doi.org/10.1590/s0001-37652013005000003.

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Ascorbic acid (AA) is able to neutralize reactive oxygen species and is essential for collagen synthesis. In aging process oxidative stress is elevated. This study aims to investigate the effects of AA supplementation on the periodontal ligament (PL) of rats during aging. Twenty five rats were used and divided into groups: J90 (90-day-old control), E345 (345-day-old control), E428 (428-day-old control), EA345 (345-day-old supplemented with AA from 90-day-old on) and EA428 (428-day-old supplemented with AA from 90-day-old on). We analyzed the thickness, density of fibroblasts and blood vessels and collagen fibers types in the PL. In group J90 there was predominantly type III collagen fibers (87.64%). In animals supplemented with AA, the area filled by type I fibers (group EA345: 65.67%, group EA428: 52.23%) was higher than type III fibers. PL in group EA428 was thicker than the one observed in group E428 (P < 0.05). During natural aging process, AA promoted the maturation of collagen fibers and enhanced angiogenesis in periodontal ligament. One can conclude that the supplementation with AA represented a beneficial factor for the development of PL in aged rats.
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Li, Qian, Yushi Ma, Yunyan Zhu, Ting Zhang, and Yanheng Zhou. "Declined Expression of Histone Deacetylase 6 Contributes to Periodontal Ligament Stem Cell Aging." Journal of Periodontology 88, no. 1 (January 2017): e12-e23. http://dx.doi.org/10.1902/jop.2016.160338.

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Shimizu, N., T. Goseki, M. Yamaguchi, T. Iwasawa, H. Takiguchi, and Y. Abiko. "In vitro Cellular Aging Stimulates Interleukin-1β Production in Stretched Human Periodontal-ligament-derived Cells." Journal of Dental Research 76, no. 7 (July 1997): 1367–75. http://dx.doi.org/10.1177/00220345970760070601.

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Although the severity of periodontal disease is known to be affected by host age, the pathological role of aging in periodontal disease, and especially that attributable to trauma from occlusion, has not been well-characterized. Interleukin (IL)-1β is a key mediator involved in periodontal diseases, a potent stimulator of bone resorption. Furthermore, it is produced by human periodontal ligament (PDL) cells in response to mechanical stress. To investigate the age-related changes in the biosynthetic capacity of IL-1β in PDL cells, we examined the effects of in vitro cellular aging with mechanical stress on IL-1β protein and gene expression by human PDL cells. Human PDL cells (young = 5th or 6th passage; old = 18-20th passage) were cultured on flexible-bottomed culture plates, and the cells were deformed at 6 cycles per min at 2 steps of tension force for 1 to 5 days. We found a two-fold increase in IL-lp production by old PDL cells subjected to mechanical tension compared with that by young PDL cells, although the constitutive levels of IL-1β were similar in both the young and old PDL cells. This increase was tension-dependent. IL-1β mRNA was also detected in both the cell types under basal conditions, and its expression was further enhanced by application of mechanical tension by use of reverse-transcription-polymerase chain-reaction (RT-PCR) and in situ hybridization methods. The increase in signal rate was higher in the old cells than in the young cells. IL-1β-converting enzyme mRNA remained unchanged. It is possible that a large amount of IL-1β produced by PDL cells from an aged host in response to mechanical force may be positively related to the accleration of alveolar bone resorption.
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Fang, Hui, Kun Yang, Ping Tang, Na Zhao, Rui Ma, Xin Luo, and Qi Liu. "Glycosylation end products mediate damage and apoptosis of periodontal ligament stem cells induced by the JNK-mitochondrial pathway." Aging 12, no. 13 (June 30, 2020): 12850–68. http://dx.doi.org/10.18632/aging.103304.

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Benatti, Bruno Braga, Karina Gonzales Silvério, Márcio Zaffalon Casati, Enilson Antônio Sallum, and Francisco Humberto Nociti Jr. "Inflammatory and bone-related genes are modulated by aging in human periodontal ligament cells." Cytokine 46, no. 2 (May 2009): 176–81. http://dx.doi.org/10.1016/j.cyto.2009.01.002.

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Zhang, Yunyan, Yuzhi Yang, Mingxue Xu, Jingwen Zheng, Yuchan Xu, Guoqing Chen, Qiang Guo, Weidong Tian, and Weihua Guo. "The Dual Effects of Reactive Oxygen Species on the Mandibular Alveolar Bone Formation in SOD1 Knockout Mice: Promotion or Inhibition." Oxidative Medicine and Cellular Longevity 2021 (February 3, 2021): 1–15. http://dx.doi.org/10.1155/2021/8847140.

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The status of reactive oxygen species (ROS) correlates closely with the normal development of the oral and maxillofacial tissues. Oxidative stress caused by ROS accumulation not only affects the development of enamel and dentin but also causes pathological changes in periodontal tissues (periodontal ligament and alveolar bone) that surround the root of the tooth. Although previous studies have shown that ROS accumulation plays a pathologic role in some oral and maxillofacial tissues, the effects of ROS on alveolar bone development remain unclear. In this study, we focused on mandibular alveolar bone development of mice deficient in superoxide dismutase1 (SOD1). Analyses were performed using microcomputerized tomography (micro-CT), TRAP staining, immunohistochemical (IHC) staining, and enzyme-linked immunosorbent assay (ELISA). We found for the first time that slightly higher ROS in mandibular alveolar bone of SOD1(-/-) mice at early ages (2-4 months) caused a distinct enlargement in bone size and increased bone volume fraction (BV/TV), trabecular thickness (Tb.Th), and expression of alkaline phosphatase (ALP), Runt-related transcription factor 2 (Runx2), and osteopontin (OPN). With ROS accumulation to oxidative stress level, increased trabecular bone separation (Tb.Sp) and decreased expression of ALP, Runx2, and OPN were found in SOD1(-/-) mice at 6 months. Additionally, dosing with N-acetylcysteine (NAC) effectively mitigated bone loss and normalized expression of ALP, Runx2, and OPN. These results indicate that redox imbalance caused by SOD1 deficiency has dual effects (promotion or inhibition) on mandibular alveolar bone development, which is closely related to the concentration of ROS and the stage of growth. We present a valuable model here for investigating the effects of ROS on mandibular alveolar bone formation and highlight important roles of ROS in regulating tissue development and pathological states, illustrating the complexity of the redox signal.
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Dissertations / Theses on the topic "Mice – Aging; Periodontal ligament – Aging"

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Cameron, John. "Endothelial junctions in the periodontal ligament microvasculature of young and aged mice." Thesis, 1995. http://hdl.handle.net/2440/110343.

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Investigates the effects of ageing on the morphology of the periodontal ligament (PDL) endothelial junctions. Tests the null hypothesis that no changes occur in proportions of 'tight' and 'close' regions, and the dimensions of endothelial junctions in the microvascular bed of aged mouse PDL. The null hypothesis is rejected.
Thesis (M.D.S.) -- University of Adelaide, Dept. of Dentistry, 1996?
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