Relevant bibliographies by topics / MFA2

Academic literature on the topic 'MFA2'

Author: Grafiati
Published: 10 December 2022
Last updated: 28 January 2023

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Journal articles on the topic "MFA2"

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Sakae, Kotaro, Keiji Nagano, Miyuna Furuhashi, and Yoshiaki Hasegawa. "Diversity analysis of genes encoding Mfa1 fimbrial components in Porphyromonas gingivalis strains." PLOS ONE 16, no. 7 (July 26, 2021): e0255111. http://dx.doi.org/10.1371/journal.pone.0255111.

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Porphyromonas gingivalis, a gram-negative anaerobic bacterium, is associated with the development of periodontal disease. The genetic diversity in virulence factors, such as adhesive fimbriae, among its strains affects the bacterial pathogenicity. P. gingivalis generally expresses two distinct types of fimbriae, FimA and Mfa1. Although the genetic diversity of fimA, encoding the major FimA fimbrilin protein, has been characterized, the genes encoding the Mfa1 fimbrial components, including the Mfa1 to Mfa5 proteins, have not been fully studied. We, therefore, analyzed their genotypes in 12 uncharacterized and 62 known strains of P. gingivalis (74 strains in total). The mfa1 genotype was primarily classified into two genotypes, 53 and 70. Additionally, we found that genotype 70 could be further divided into two subtypes (70A and 70B). The diversity of mfa2 to mfa4 was consistent with the mfa1 genotype, although no subtype in genotype 70 was observed. Protein structure modeling showed high homology between the genotypes in Mfa1 to Mfa4. The mfa5 gene was classified into five genotypes (A to E) independent of other genotypes. Moreover, genotype A was further divided into two subtypes (A1 and A2). Surprisingly, some strains had two mfa5 genes, and the 2nd mfa5 exclusively occurred in genotype E. The Mfa5 protein in all genotypes showed a homologous C-terminal half, including the conserved C-terminal domain recognized by the type IX secretion system. Furthermore, the von Willebrand factor domain at the N-terminal was detected only in genotypes A to C. The mfa1 genotypes partially correlated with the ragA and ragB genotypes (located immediately downstream of the mfa gene cluster) but not with the fimA genotypes.
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Hasegawa, Yoshiaki, Jun Iwami, Keiko Sato, Yoonsuk Park, Kiyoshi Nishikawa, Tatsuo Atsumi, Keiichi Moriguchi, et al. "Anchoring and length regulation of Porphyromonas gingivalis Mfa1 fimbriae by the downstream gene product Mfa2." Microbiology 155, no. 10 (October 1, 2009): 3333–47. http://dx.doi.org/10.1099/mic.0.028928-0.

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Porphyromonas gingivalis, a causative agent of periodontitis, has at least two types of thin, single-stranded fimbriae, termed FimA and Mfa1 (according to the names of major subunits), which can be discriminated by filament length and by the size of their major fimbrilin subunits. FimA fimbriae are long filaments that are easily detached from cells, whereas Mfa1 fimbriae are short filaments that are tightly bound to cells. However, a P. gingivalis ATCC 33277-derived mutant deficient in mfa2, a gene downstream of mfa1, produced long filaments (10 times longer than those of the parent), easily detached from the cell surface, similar to FimA fimbriae. Longer Mfa1 fimbriae contributed to stronger autoaggregation of bacterial cells. Complementation of the mutant with the wild-type mfa2 allele in trans restored the parental phenotype. Mfa2 is present in the outer membrane of P. gingivalis, but does not co-purify with the Mfa1 fimbriae. However, co-immunoprecipitation demonstrated that Mfa2 and Mfa1 are associated with each other in whole P. gingivalis cells. Furthermore, immunogold microscopy, including double labelling, confirmed that Mfa2 was located on the cell surface and likely associated with Mfa1 fimbriae. Mfa2 may therefore play a role as an anchor for the Mfa1 fimbriae and also as a regulator of Mfa1 filament length. Two additional downstream genes (pgn0289 and pgn0290) are co-transcribed with mfa1 (pgn0287) and mfa2 (pgn0288), and proteins derived from pgn0289, pgn0290 and pgn0291 appear to be accessory fimbrial components.
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Michaelis, S., and I. Herskowitz. "The a-factor pheromone of Saccharomyces cerevisiae is essential for mating." Molecular and Cellular Biology 8, no. 3 (March 1988): 1309–18. http://dx.doi.org/10.1128/mcb.8.3.1309-1318.1988.

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The Saccharomyces cerevisiae pheromone a-factor is produced by a cells and interacts with alpha cells to cause cell cycle arrest and other physiological responses associated with mating. Two a-factor structural genes, MFA1 and MFA2, have been previously cloned with synthetic probes based on the a-factor amino acid sequence (A. Brake, C. Brenner, R. Najarian, P. Laybourn, and J. Merryweather, cited in M.-J. Gething [ed.], Protein transport and secretion, 1985). We have examined the function of these genes in a-factor production and mating by construction and analysis of chromosomal null mutations. mfa1 and mfa2 single mutants each exhibited approximately half the wild-type level of a-factor activity and were proficient in mating, whereas the mfa1 mfa2 double mutant produced no a-factor and was unable to mate. These results demonstrate that both genes are functional, that each gene makes an equivalent contribution to the a-factor activity and mating capacity of a cells, and that a-factor plays an essential role in mating. Strikingly, exogenous a-factor did not alleviate the mating defect of the double mutant, suggesting that an a cell must be producing a-factor to be an effective mating partner.
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Michaelis, S., and I. Herskowitz. "The a-factor pheromone of Saccharomyces cerevisiae is essential for mating." Molecular and Cellular Biology 8, no. 3 (March 1988): 1309–18. http://dx.doi.org/10.1128/mcb.8.3.1309.

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The Saccharomyces cerevisiae pheromone a-factor is produced by a cells and interacts with alpha cells to cause cell cycle arrest and other physiological responses associated with mating. Two a-factor structural genes, MFA1 and MFA2, have been previously cloned with synthetic probes based on the a-factor amino acid sequence (A. Brake, C. Brenner, R. Najarian, P. Laybourn, and J. Merryweather, cited in M.-J. Gething [ed.], Protein transport and secretion, 1985). We have examined the function of these genes in a-factor production and mating by construction and analysis of chromosomal null mutations. mfa1 and mfa2 single mutants each exhibited approximately half the wild-type level of a-factor activity and were proficient in mating, whereas the mfa1 mfa2 double mutant produced no a-factor and was unable to mate. These results demonstrate that both genes are functional, that each gene makes an equivalent contribution to the a-factor activity and mating capacity of a cells, and that a-factor plays an essential role in mating. Strikingly, exogenous a-factor did not alleviate the mating defect of the double mutant, suggesting that an a cell must be producing a-factor to be an effective mating partner.
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Vasudevan, Shobha, Nicole Garneau, Danny Tu Khounh, and Stuart W. Peltz. "p38 Mitogen-Activated Protein Kinase/Hog1p Regulates Translation of the AU-Rich-Element-Bearing MFA2 Transcript." Molecular and Cellular Biology 25, no. 22 (November 15, 2005): 9753–63. http://dx.doi.org/10.1128/mcb.25.22.9753-9763.2005.

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ABSTRACT AU-rich-element (ARE)-mediated mRNA regulation occurs in Saccharomyces cerevisiae in response to external and internal stimuli through the p38 mitogen-activated protein kinase (MAPK)/Hog1p pathway. We demonstrate that the ARE-bearing MFA2 3′ untranslated region (UTR) controls translation efficiency in a p38 MAPK/Hog1p-dependent manner in response to carbon source growth conditions. The carbon source-regulated effect on MFA2 3′-UTR-controlled translation involves the role of conserved ARE binding proteins, the ELAV/TIA-1-like Pub1p, which can interact with the cap/eIF4G complex, and the translation/mRNA stability factor poly(A) binding protein (Pab1p). Pub1p binds the MFA2 3′-UTR in a p38 MAPK/Hog1p-regulated manner in response to carbon source growth conditions. Significantly, the p38 MAPK/Hog1p is also required to modulate Pab1p in response to carbon source. We find that Pab1p can bind the MFA2 3′-UTR in a regulated manner to control MFA2 3′-UTR reporter translation. Binding of full-length Pab1p to the MFA2 3′-UTR correlates with translation repression. Importantly, Pab1p binds the MFA2 3′-UTR only in a PUB1 strain, and correlating with this requirement, Pub1p controls translation repression of MFA2 in a carbon source/Hog1p-regulated manner. These results suggest that the p38 MAPK/Hog1p pathway regulates 3′-UTR-mediated translation by modulating recruitment of Pab1p and Pub1p, which can interact with the translation machinery.
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Duttagupta, Radharani, Shobha Vasudevan, Carol J. Wilusz, and Stuart W. Peltz. "A Yeast Homologue of Hsp70, Ssa1p, Regulates Turnover of the MFA2 Transcript through Its AU-Rich 3′ Untranslated Region." Molecular and Cellular Biology 23, no. 8 (April 15, 2003): 2623–32. http://dx.doi.org/10.1128/mcb.23.8.2623-2632.2003.

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ABSTRACT Many eukaryotic mRNAs exhibit regulated decay in response to cellular signals. AU-rich elements (AREs) identified in the 3′ untranslated region (3′-UTR) of several such mRNAs play a critical role in controlling the half-lives of these transcripts. The yeast ARE-containing mRNA, MFA2, has been studied extensively and is degraded by a deadenylation-dependent mechanism. However, the trans-acting factors that promote the rapid decay of MFA2 have not been identified. Our results suggest that the chaperone protein Hsp70, encoded by the SSA family of genes, is involved in modulating MFA2 mRNA decay. MFA2 is specifically stabilized in a strain bearing a temperature-sensitive mutation in the SSA1 gene. Furthermore, an AU-rich region within the 3′-UTR of the message is both necessary and sufficient to confer this regulation. Stabilization occurs as a result of slower deadenylation in the ssa1ts strain, suggesting that Hsp70 is required for activation of the turnover pathway.
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Aronov, Stella, Saray Dover-Biterman, Edith Suss-Toby, Michael Shmoish, Lea Duek, and Mordechai Choder. "Pheromone-encoding mRNA is transported to the yeast mating projection by specific RNP granules." Journal of Cell Biology 209, no. 6 (June 22, 2015): 829–42. http://dx.doi.org/10.1083/jcb.201408045.

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Association of messenger RNAs with large complexes such as processing bodies (PBs) plays a pivotal role in regulating their translation and decay. Little is known about other possible functions of these assemblies. Exposure of haploid yeast cells, carrying mating type “a,” to “α pheromone” stimulates polarized growth resulting in a “shmoo” projection; it also induces synthesis of “a pheromone,” encoded by MFA2. In this paper, we show that, in response to α pheromone, MFA2 mRNA is assembled with two types of granules; both contain some canonical PB proteins, yet they differ in size, localization, motility, and sensitivity to cycloheximide. Remarkably, one type is involved in mRNA transport to the tip of the shmoo, whereas the other—in local translation in the shmoo. Normal assembly of these granules is critical for their movement, localization, and for mating. Thus, MFA2 mRNAs are transported to the shmoo tip, in complex with PB-like particles, where they are locally translated.
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Geva, Polina, Konstantin Komoshvili, and Stella Liberman-Aronov. "Two- and Three-Dimensional Tracking of MFA2 mRNA Molecules in Mating Yeast." Cells 9, no. 10 (September 23, 2020): 2151. http://dx.doi.org/10.3390/cells9102151.

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Intracellular mRNA transport contributes to the spatio-temporal regulation of mRNA function and localized translation. In the budding yeast, Saccharomyces cerevisiae, asymmetric mRNA transport localizes ~30 specific mRNAs including those encoding polarity and secretion factors, to the bud tip. The underlying process involves RNA-binding proteins (RBPs), molecular motors, processing bodies (PBs), and the actin cytoskeleton. Recently, pheromone a-factor expression in mating yeast was discovered to depend on proper localization of its mRNA, MFA2 mRNAs in conjunction with PBs cluster at the shmoo tip to form “mating bodies”, from which a-factor is locally expressed. The mechanism ensuring the correct targeting of mRNA to the shmoo tip is poorly understood. Here we analyzed the kinetics and trajectories of MFA2 mRNA transport in living, alpha-factor treated yeast. Two- (2D) and three-dimensional (3D) analyses allowed us to reconstruct the granule tracks and estimate granule velocities. Tracking analysis of single MFA2 mRNA granules, labeled using a fluorescent aptamer system, demonstrated three types movement: vibrational, oscillatory and translocational. The mRNA granule transport was complex; a granule could change its movement behavior and composition during its journey to the shmoo. Processing body assembly and the actin-based motor, Myo4p, were involved in movement of MFA2 mRNA to the shmoo, but neither was required, indicating that multiple mechanisms for translocation were at play. Our visualization studies present a dynamic view of the localization mechanism in shmoo-bearing cells.
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Hirschhorn, J. N., and F. Winston. "SPT3 is required for normal levels of a-factor and alpha-factor expression in Saccharomyces cerevisiae." Molecular and Cellular Biology 8, no. 2 (February 1988): 822–27. http://dx.doi.org/10.1128/mcb.8.2.822-827.1988.

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Mutations in the Saccharomyces cerevisiae SPT3 gene were previously found to cause suppression of Ty and delta insertion mutations in 5'-noncoding regions of genes. This suppression likely results from the fact that SPT3 is required for transcription initiation in delta sequences. Other additional phenotypes of spt3 mutants, including a mating defect, suggest that SPT3 is required for normal levels of expression of other genes. We analyzed the mating defect in spt3 mutants and showed that the levels of transcripts of the three major mating pheromone genes, MF alpha 1, MFa1, MFa2, were all reduced. The reduction in expression of these genes in spt3 mutants was not due to expression of a silent mating type cassette. Furthermore, we showed that the spt3 mating defect was manifest at the levels of both cellular fusion and nuclear fusion.
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Hirschhorn, J. N., and F. Winston. "SPT3 is required for normal levels of a-factor and alpha-factor expression in Saccharomyces cerevisiae." Molecular and Cellular Biology 8, no. 2 (February 1988): 822–27. http://dx.doi.org/10.1128/mcb.8.2.822.

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Mutations in the Saccharomyces cerevisiae SPT3 gene were previously found to cause suppression of Ty and delta insertion mutations in 5'-noncoding regions of genes. This suppression likely results from the fact that SPT3 is required for transcription initiation in delta sequences. Other additional phenotypes of spt3 mutants, including a mating defect, suggest that SPT3 is required for normal levels of expression of other genes. We analyzed the mating defect in spt3 mutants and showed that the levels of transcripts of the three major mating pheromone genes, MF alpha 1, MFa1, MFa2, were all reduced. The reduction in expression of these genes in spt3 mutants was not due to expression of a silent mating type cassette. Furthermore, we showed that the spt3 mating defect was manifest at the levels of both cellular fusion and nuclear fusion.
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Dissertations / Theses on the topic "MFA2"

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Teng, Y. "Nucleotide excision repair in the Saccharomyces cerevisiae MFA2 gene." Thesis, Swansea University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.639174.

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An end-labelling strategy for mapping DNA damage in yeast Saccharomyces cerevisiae at the level of the nucleotide is presented. Compared with other high resolution damage mapping protocols, the method described in this thesis is simpler and more efficient with less radioactive manipulation. The MFA2 gene, which is actively transcribed in a-mating type cells whereas repressed in α-mating type cells, provides an ideal model system for studying DNA repair due to its small size and easy control of its expression. The data from nucleotide excision repair competent strains showed that repair of Cyclobutane Pyrimidine Dimers (CPDs) in the upstream region of the MFA2 gene is enhanced in the Mcm1 binding region, and the closer to the transcription start point, the quicker the repair rate observed except for the TATA box region. This enhanced repair rate becomes fastest in the MFA2 transcribed region due to the transcription-coupled repair (TCR). The data from the rad16 mutant strain provided the first evidence that Rad16 is not absolutely required to repair CPDs in some upstream control sequences despite being nontranscribed regions. Experiments with a rad26 mutant showed that Rad26 is essential for TCR of the whole MFA2 transcribed region. Here, although TCR was abolished in the transcribed region, enhanced repair still occurred in the control region of MFA2. Studies with yeast replication protein A mutants indicated that the DNA binding domain, not the protein interaction domain of RPA70, confers a defect in global repair and only partly impairs the process of TCR. The experiments with transcription adaptor mutants, Δgcn5 and Δada2, identified a requirement for these gene products in Nucleotide Excision Repair (NER) of CPDs. Comparing the two adaptors examined, Gcn5 plays a more important role than Ada2 in both MFA2 transcription and CPD repair.
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Yu, S. "Nucleotide excision repair and nucleosome positioning in the Saccharomyces cerevisiae MFA2 gene." Thesis, Swansea University, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.636719.

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The Saccharomyces cerevisiae checkpoint genes RAD9, RAD17, RAD24, and MEC3 are required for the transcriptional induction of a group of genes including some for DNA repair. In this thesis two of the checkpoint genes, RAD9 and RAD24, and two nucleotide excision repair (NER) genes RAD16 and RAD26, have been investigated for their role in inducible NER at the MFA2 gene at nucleotide resolution. In wild type cells, enhanced NER is detected in cells received a minor UV irradiation one hour prior to a main UV dose compared to cells only treated with the main UV dose. This inducible NER is not detectable in mutant strains rad9, rad24, rad9rad24, rad16 and rad26. These data suggest that inducible NER is dependent on the checkpoint genes RAD9 and RAD24, on the RAD16 gene that is essential for global genome repair (GGR), and on the RAD26 gene that is required for efficient transcription-coupled repair (TCR). A second aspect of the thesis examined the role of histone acetylation in NER. Histone acetyltransferases (HATs) play an important role in remodelling chromatin structure during transcription activation. Here, the role of one HAT, Gen5, in the NER of UV induced CPDs in the upstream region of MFA2 has been examined. In Δgcn5 strains, NER of both strands in the control region of MFA2 is slower than in wild type cells. As Gen5 regulates MFA2 transcription, probably through chromatin modification, its role in chromatin organization in the control region of MFA2 would appear to influence DNA repair in that region.
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Liu, Hairong. "DNA repair and transcription of the yeast MFA2 gene : roles of Tup1p, Gcn5p and Rad16p." Thesis, Cardiff University, 2005. http://orca.cf.ac.uk/54096/.

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To clarify the role of one of the general chromatin remodelling factors-the histone acetylase Gcn5p in NER, I undertook experiments with Δgcn5 and Δtup1gcn5 strains.
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Jokubaityte, Gintare. "Assessment of polymerization possibilities of two fimbriae proteins, Mfa3 and Mfa4, in Porphyromonas gingivalis." Thesis, Umeå universitet, Kemiska institutionen, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-150541.

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Porobic, Damir Verona. "MFA thesis exhibition." Morgantown, W. Va. : [West Virginia University Libraries], 2005. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=4189.

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Thesis (M.F.A.)--West Virginia University, 2005.
Title from document title page. Document formatted into pages; contains vi, 30 p. : ill. (some col.). Includes a video file in the QuickTime format. Includes abstract. Includes bibliographical references (p. 30).
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Cuevas, Santamaría Sergio Axel. "My MFA Experience." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1524073680662621.

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Tur, Torres Juan. "Role of Mfn2 in Macrophage Inflammatory Responses." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/402898.

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Mitochondria are well known for their role as bioenergetic and biosynthetic organelles. Recently, they also have emerged as one of the main regulators of innate immune responses, mostly for its ability to modulate several signaling pathways through mechanisms such ROS production. Mitofusin-2 (Mfn2) is a GTPase located in the external mitochondrial and ER membranes. It is responsible for the fusion between mitochondria and the ER-mitochondria contacts, both necessary for the correct functioning of both organelles. Even that, the role of Mfn2 in immune responses. Here we demonstrate that Mfn2 is crucial for the pro-inflammatory activation of macrophages. Murine Mfn2-/- macrophages show a disruption in the mitochondrial network morphology that leads to loss in the mitochondrial membrane potential and in mitochondrial respiration. These two defects in the mitochondrial function do not affect their ability to normally generate ATP. However, the production of ROS in the mitochondria from Mfn2-/- macrophages is markedly decreased. This defect in ROS generation leads to a severe dysfunction in macrophage responses, particularly in the inflammatory activation, phagocytosis, and the processing of proteins. First, the decrease in ROS in Mfn2-/- macrophages results in a defective activation of p38, ERK, and NF-kB signaling pathways in response to LPS. The decrease in these signaling cascades leads to a reduction in the production of pro- inflammatory cytokines, severely impairing their ability to undergo pro- inflammatory activation. Second, in addition to show reduced ROS levels, Mfn2-/- also show an accumulation of autophagosomes due to a Mfn2-dependent defect in the autophagosome-lysosome fusion. As a result to both increased autophagy and decreased ROS levels, Mfn2-/- macrophages show decreased expression of type- A scavenger receptors. We demonstrate that these alterations lead to a widespread defect in the phagocytic capabilities of Mfn2-/- macrophages, showing defective phagocytosis of bacteria (both gram positive and gram negative) and apoptotic bodies. Thirdly, Mfn2-/- macrophages also show a defect in the bactericidal activity of phagocyted bacteria, as well as a defective proteolysis, being unable to process antigens to present them to CD4+ cells in a MHC-II context, and therefore, potentially impairing their ability to initiate adaptive immune responses. Finally, we demonstrated that Mfn2 is relevant in in vivo models of inflammation or infection. Myeloid-conditional Mfn2-/- mice were infected with either Listeria monocytogenes or Mycobacterium tuberculosis. In both models, Mfn2-/- mice showed a severe decrease in their survival, when compared to their WT counterparts. Furthermore, the colony counts in selected organs (spleen and liver for listeria, spleen and lung for tuberculosis) was significantly increased in Mfn2-/- mice, indicating that Mfn2 in macrophages is required to effectively control bacterial infections. In addition, we performed a model of sterile inflammation using the irritant DNFB on the mice’s ear. Confirming the in vitro results, Mfn2-/- mice show decreased inflammation in the ear, as confirmed by the decrease in size and weight, and the reduced expression of inflammatory cytokines. All these findings suggest that Mfn2 is a crucial regulator of macrophage pro- inflammatory responses, including production of pro-inflammatory cytokines, phagocytosis, and antigen presentation, through modulation of mitochondrial ROS production, autophagy, and protein processing.
Apart del seu rol en la regulació del metabolisme, és cada cop més acceptat els mitocondris són un dels principals controladors de les respostes immunes. En aquesta tesi ens centrem en l’estudi de Mitofusina 2 (Mfn2), una GTPasa que es troba a la membrana mitocondrial externa i que promou la fusió entre mitocondris. Degut a que Mfn2 controla aspectes clau de la fisiologia mitocondrial com la respiració, la producció de ROS i l’apoptosi, tots ells intrínsecament lligats en el funcionament de les respostes immunes, decidim estudiar el paper que juga aquesta proteïna en els macròfags, cèl·lules clau en la inflamació. Els macròfags Mfn2-/- presenten una xarxa mitocondrial completament fragmentada, així com una pèrdua del potencial de membrana mitocondrial i una disminució de la respiració. Això fa que les mitocòndries d’aquestes cèl·lules, tot i generar ATP de forma normal, siguin incapaces de produir nivells fisiològics de ROS. Aquesta disminució de ROS provoca que vies de senyalització com ERK, p38 i NF-κB no puguin ser activades per LPS, portant els macròfags Mfn2-/- a ser incapaços de sintetitzar citocines inflamatòries com el TNF-α o la IL-1β, i per tant de generar una resposta inflamatòria eficient. Per altra banda, la deficiència de Mfn2 provoca una acumulació d’autofagosomes en els macròfags. Això genera per una banda un increment de l’apoptosi en aquestes cèl·lules, i per altra un defecte en la seva capacitat fagocítica. Tot això a més és combina amb un defecte en la degradació de bacteris fagocitats i el processament de proteïnes necessari per la presentació antigènic, probablement degut també a la falta de ROS. Finalment demostrem que Mfn2 és crucial en les respostes inflamatòries usant 3 models in vivo. En dos d’ells mostrem com els macròfags necessiten Mfn2 per controlar les infeccions de listèria i tuberculosis, mentre que el l’últim demostrem que Mfn2 també és necessària en la inflamació asèptica. Per concloure, en aquesta tesi demostrem que la Mfn2 és crucial per l’activació pro- inflamatòria del macròfag, afectant tres processos clau: la producció de citocines inflamatòries, la fagocitosi i la presentació antigènica.
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Caudill, Ross Steven. "Ross Caudill MFA Sculpture 2006." VCU Scholars Compass, 2006. http://scholarscompass.vcu.edu/etd/1407.

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This thesis overviews my experience during graduate school making tangible,object oriented sculpture. I have been working formally to compose space in a way that develops a narrative between parts. The work is also a bridge between the fields of painting and sculpture, in terms of drawing with form and both painted and local, material color. My palette has mostly consisted of bronze casting, steel fabrication, fiberglass and epoxy resin, paint, the found object, woodworking, and mold making. This work is also conceptually based in showing the hand worked qualities of the materials, the transfer of meaning through casting, and my emotional relationship with the various parts of the sculptures. The three major themes of the work are: divine love and the complex of the apocalypse, the complexities and psychology concerning the relationship between a man and a woman, and the intrigue, potential energy, and beauty of the systems mankind hasinvented to harness the atom. The major artistic influences for this body of work have been: Jasper Johns, Marcel Duchamp, Constantine Brancusi, Alberto Giacommetti, Reg Butler, Henry Moore, Lynn Chadwick, Kenneth Armitage, Jeff Koons, Terry Winters, William DeKooning, Richard Diebenkorn, David Smith and Charles Long. I retain a strongrelationship with the movements of Dada, Surrealism, Futurism, and Assemblage, and amalso currently involved in solidifying the Manifesto of Raubeaux with a small group ofesteemed colleagues.
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Jilka, Milan. "Artistic Learning in an MFA Community." Thesis, University of North Texas, 2019. https://digital.library.unt.edu/ark:/67531/metadc1538710/.

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The purpose of this phenomenographical case study is to explore the ways in which a group of MFA students conceive of their learning as they are enmeshed within an MFA community. The research follows along two guiding research questions: 1) What does artistic learning involve for graduate students in an MFA community? 2) How is one's artistic practice shaped by one's active participation in an MFA community? The findings of this study have been presented as lines of artistic learning and help to show the various conceptions that MFA students have of their learning as artists while in an MFA program of study. Ultimately, it is in better understanding one's lines of artistic learning that MFA students can be better supported in their journeying to become professional, practicing artists.
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Grandjean, Didier. "Contribution à l'étude des solutions solides de type fluorine MF2-NdF3 et MF2-UF4 (M = Ca, Ba)." Montpellier 2, 1991. http://www.theses.fr/1991MON20032.

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Differentes compositions des solutions solides heterotypiques de type fluorine ba#1##xu#xf#2#+#2#x, ba#1##xnd#xf#2#+#x et ca#1##xnd#xf#2#+#x, ont ete preparees et caracterisees par diffraction des rayons x. Des mesures d'impedance, realisees jusqu'a 800c sur toutesles compositions, ont permis de mettre en evidence l'evolution des proprietes electriques et de caracteriser la conductivite en fonction de la composition et de la nature de l'ion aliovalent. Une etude par spectroscopie exafs des differentes compositions de la solution solide ba#1##xu#xf#2#+#2#x nous a permis, a la lumiere des mesures de conductivite, de contribuer a une meilleure comprehension de l'environnement local de l'eatome d'uranium et des phenomenes de diffusion au sein du reseau hote baf#2. Dans le cadre d'une convention de recherche industrie-universite, une etude par analyse thermique differentielle a l'echauffement du phenomene d'initialisation de la reaction de reduction du trifluorure de neodyme par le calcium a ete realisee
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Books on the topic "MFA2"

1

Lay, Chuck. Proud past, bright future: MFA Incorporated's first 100 years. Virginia Beach, VA: Donning Company Publishers, 2013.

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Faini, Riccardo. A primer on the MFA maze. Washington, DC (1818 H St. NW Washington 20433): Country Economics Dept., World Bank, 1993.

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Woldekidan, Berhanu. Mauritian clothing exports without the MFA. Canberra, Australia: Research School of Pacific Studies, ANU, 1992.

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Spinanger, Dean. Textiles beyond the MFA phase-out. Warwick: University of Warwick, 1998.

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Faini, Riccardo. A primer on the MFA maze. London: Centre for Economic Policy Research, 1992.

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Whalley, John. The post MFA performance of developing Asia. Cambridge, Mass: National Bureau of Economic Research, 2006.

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Whalley, John. The post MFA performance of developing Asia. Cambridge, MA: National Bureau of Economic Research, 2006.

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Workshop, New York Writers, ed. The portable MFA in creative writing: Improve your craft with the core essentials taught to MFA students. Cincinnati, OH: Writer's Digest Books, 2006.

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Finger, J. M. The MFA paradox: More protection and more trade? Cambridge, MA: National Bureau of Economic Research, 1994.

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America, College Art Association of. Directory of MFA programs in the visual arts. New York: College Art Association, 1999.

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Book chapters on the topic "MFA2"

1

Jazmin, Lara J., John P. O’Grady, Fangfang Ma, Doug K. Allen, John A. Morgan, and Jamey D. Young. "Isotopically Nonstationary MFA (INST-MFA) of Autotrophic Metabolism." In Plant Metabolic Flux Analysis, 181–210. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-688-7_12.

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Hicks, Richard M. "Azure MFA Integration." In Implementing Always On VPN, 269–87. Berkeley, CA: Apress, 2021. http://dx.doi.org/10.1007/978-1-4842-7741-6_9.

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Lu, Suihua, and Aubrey B. Poore. "Network-Centric MFA Tracking Architectures." In Cooperative Systems, 187–213. Boston, MA: Springer US, 2003. http://dx.doi.org/10.1007/978-1-4757-3758-5_10.

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Bashford, David. "Tetrafluoroethylene and Perfluoromethylvinylether Copolymer (MFA)." In Thermoplastics, 242. Dordrecht: Springer Netherlands, 1997. http://dx.doi.org/10.1007/978-94-009-1531-2_41.

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Hasegawa, Yoshiaki, Keiji Nagano, Yukitaka Murakami, and Richard J. Lamont. "Purification of Native Mfa1 Fimbriae from Porphyromonas gingivalis." In Periodontal Pathogens, 75–86. New York, NY: Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0939-2_8.

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Geng, Bingqian, Congyan Lang, Junliang Xing, Songhe Feng, and Wu Jun. "MFAD: A Multi-modality Face Anti-spoofing Dataset." In PRICAI 2019: Trends in Artificial Intelligence, 214–25. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-29911-8_17.

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Hu, Bo, and Malgorzata Marek-Sadowska. "mFAR: Multilevel Fixed-Points Addition-Based VLSI Placement." In Series on Integrated Circuits and Systems, 229–45. Boston, MA: Springer US, 2007. http://dx.doi.org/10.1007/978-0-387-68739-1_9.

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Tamura, Makoto. "Climate Change Risk and Adaptation." In Interlocal Adaptations to Climate Change in East and Southeast Asia, 1–16. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-81207-2_1.

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AbstractClimate change is considered by many to be the most critical issue of our time, posing a threat to security and socio-economic prosperity at the global level (MFAJ 2017). Asia is very vulnerable to the impacts of climate change, as more than 60% (approximately 4.5 billion) of the world’s people live in the region, making it a growth center of the world (UNDESA 2017).
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von Schöppenthau, Philip. "Konklusion: Die zwei Dimensionen des MFA-Regimewandels." In Die Europäische Union als Akteur der internationalen Handelspolitik, 285–311. Wiesbaden: Deutscher Universitätsverlag, 1999. http://dx.doi.org/10.1007/978-3-663-08386-3_12.

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Steinbach, Adalbert. "Materialflussanalyse (MFA) Als Basis Eines Umweltorientierten Controllings." In Informatik für den Umweltschutz / Computer Science for Environmental Protection, 182–92. Berlin, Heidelberg: Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-642-77164-4_19.

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Conference papers on the topic "MFA2"

1

Hu, Bo, Yue Zeng, and Malgorzata Marek-Sadowska. "mFAR." In the 2005 international symposium. New York, New York, USA: ACM Press, 2005. http://dx.doi.org/10.1145/1055137.1055189.

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Perez-Rua, Juan-Manuel, Valentin Vielzeuf, Stephane Pateux, Moez Baccouche, and Frederic Jurie. "MFAS: Multimodal Fusion Architecture Search." In 2019 IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR). IEEE, 2019. http://dx.doi.org/10.1109/cvpr.2019.00713.

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De Bruyn, Maxime, Ehsan Lotfi, Jeska Buhmann, and Walter Daelemans. "MFAQ: a Multilingual FAQ Dataset." In Proceedings of the 3rd Workshop on Machine Reading for Question Answering. Stroudsburg, PA, USA: Association for Computational Linguistics, 2021. http://dx.doi.org/10.18653/v1/2021.mrqa-1.1.

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Johnson, Alexander D., Jacob Tamasy, James F. Fung, and Benjamin McMahon. "Development of Balanced TCDA for MFAs." In 2022 IEEE International Symposium on Phased Array Systems & Technology (PAST). IEEE, 2022. http://dx.doi.org/10.1109/past49659.2022.9975072.

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Lu, Suihua, Aubrey B. Poore, and Brian J. Suchomel. "Network MFA tracking architectures." In International Symposium on Optical Science and Technology, edited by Oliver E. Drummond. SPIE, 2001. http://dx.doi.org/10.1117/12.492749.

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Han, K. H., H. Kim, and Y. C. Chung. "Multi-purpose Fiber-optic Access Network (MFAN)." In Optical Fiber Communication Conference. Washington, D.C.: OSA, 2001. http://dx.doi.org/10.1364/ofc.2001.wn4.

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Zheng, Jiaqi, Xi Zhang, Sanchuan Guo, Quan Wang, Wenyu Zang, and Yongdong Zhang. "MFAN: Multi-modal Feature-enhanced Attention Networks for Rumor Detection." In Thirty-First International Joint Conference on Artificial Intelligence {IJCAI-22}. California: International Joint Conferences on Artificial Intelligence Organization, 2022. http://dx.doi.org/10.24963/ijcai.2022/335.

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Rumor spreaders are increasingly taking advantage of multimedia content to attract and mislead news consumers on social media. Although recent multimedia rumor detection models have exploited both textual and visual features for classification, they do not integrate the social structure features simultaneously, which have shown promising performance for rumor identification. It is challenging to combine the heterogeneous multi-modal data in consideration of their complex relationships. In this work, we propose a novel Multi-modal Feature-enhanced Attention Networks (MFAN) for rumor detection, which makes the first attempt to integrate textual, visual, and social graph features in one unified framework. Specifically, it considers both the complement and alignment relationships between different modalities to achieve better fusion. Moreover, it takes into account the incomplete links in the social network data due to data collection constraints and proposes to infer hidden links to learn better social graph features. The experimental results show that MFAN can detect rumors effectively and outperform state-of-the-art methods.
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Yan Jingwen and Hou Zhongsheng. "Convergence of MFAC based feedback-feedforward ILC systems." In 2008 Chinese Control Conference (CCC). IEEE, 2008. http://dx.doi.org/10.1109/chicc.2008.4604919.

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Tao, Mo, Zhiwu Ke, Xianling Li, Ruotong Qu, Zhenxing Zhao, Jun Wu, and Yong Li. "The Research of the Model-Free Adaptive Control Method of Once-Through Steam Generator in Nuclear Power." In 2017 25th International Conference on Nuclear Engineering. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/icone25-66489.

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Due to the increasingly complexity of the nuclear power device system, the demands for its performance and security become rather high. Once through steam generator (OTSG) has been widely researched and applied because of its practical advantages like simple structure and small volume, good static performance and mobility. It can produce superheated steam, can work without dehumidification device, and can improve the thermal efficiency of a system. However OTSG has evidently shortages on tight coupling, nonlinearity, large hysteresis and strong interference. That makes its controller designing faces with great challenges. Keeping to the topic of OTSG (Including the feed pump and the feed valve), the main study subjects of this paper are: Firstly, identifying the plant system and researching the four stages changing of the steam pressure by driving the feed valve with a step signal. Non-minimum phase characteristic is found in the second stage. Secondly, discussing whether MFAC and PID are applicable to the non-minimum phase characteristic in the second stage of steam pressure changing. Whether they can eliminate the changing in the first stage, overcome the non-minimum phase characteristic, and finally reduce the cyclic stress damage of OTSG. Thirdly, for the “feed valve-steam pressure” channel, adjusting the feed valve to track the steam pressure. Then, whether the adjusting of the feed valve can resist the disturbance on steam pressure is researched. This research can help us avoid adjusting the circuit and the feed pump frequently and enhances the reliability and security of the system on the premise that no adjust on feed valve and the power of the first circuit. Compared with the simulation result of PID, the convergence rate of MFAC is evidently faster than PID’s. In brief, MFAC has obvious superiorities in tracking, adapting, anti-interference and overcoming large hysteresis when compared with PID controller.
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Pham, Hoang Anh, and Dirk Söffker. "Modified Model-Free Adaptive Control Method Applied to Vibration Control of an Elastic Crane." In ASME 2019 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/detc2019-97654.

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Abstract Model-free adaptive control (MFAC) is a data-driven control approach receiving increased attention in the last years. Different model-free-based control strategies are proposed to design adaptive controllers when mathematical models of the controlled systems should not be used or are not available. Using only measurements (I/O data) from the system, a feedback controller is generated without the need of any structural information about the controlled plant. In this contribution an improved MFAC is discussed for control of unknown multivariable flexible systems. The main improvement in control input calculation is based on the consideration of output tracking errors and its variations. A new updated control input algorithm is developed. The novel idea is firstly applied for controlling vibrations of a MIMO ship-mounted crane. The control efficiency is verified via numerical simulations. The simulation results demonstrate that vibrations of the elastic boom and the payload of the crane can be reduced significantly and better control performance is obtained when using the proposed controller compared to standard model-free adaptive and PI controllers.
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Reports on the topic "MFA2"

1

Nelson, J. V. Irradiation data for the MFA-1 and MFA-2 tests in the FFTF. Office of Scientific and Technical Information (OSTI), April 1997. http://dx.doi.org/10.2172/16897.

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Nelson, J. V. Irradiation data for the MFA-1 and MFA-2 tests during FFTF cycles 10A and 10B. Office of Scientific and Technical Information (OSTI), October 1996. http://dx.doi.org/10.2172/332177.

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Trela, Irene, and John Whalley. Do Developing Countries Lose From the MFA? Cambridge, MA: National Bureau of Economic Research, June 1988. http://dx.doi.org/10.3386/w2618.

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Whalley, John. The Post MFA Performance of Developing Asia. Cambridge, MA: National Bureau of Economic Research, May 2006. http://dx.doi.org/10.3386/w12178.

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Cohn, David B., David Fink, John H. Wang, and Russell E. Warren. Feasibility Study for the Mini-Frequency Agile Laser (MFAL) LIDAR System. Fort Belvoir, VA: Defense Technical Information Center, January 2002. http://dx.doi.org/10.21236/ada399950.

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Finger, J. Michael, and Ann Harrison. The MFA Paradox: More Protection and More Trade? Cambridge, MA: National Bureau of Economic Research, May 1994. http://dx.doi.org/10.3386/w4751.

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Evans, Carolyn, and James Harrigan. Tight Clothing: How the MFA Affects Asian Apparel Exports. Cambridge, MA: National Bureau of Economic Research, January 2004. http://dx.doi.org/10.3386/w10250.

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Herrington, Karen, David Walker, Eric Goodman, Jim Jokl, and Scott Cantor. Multi-Factor Authentication (MFA) Interoperability Profile Working Group Final Report. Internet2, June 2016. http://dx.doi.org/10.26869/ti.36.1.

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Trela, Irene, and John Whalley. Internal Quota Allocation Schemes and the Costs of the MFA. Cambridge, MA: National Bureau of Economic Research, February 1991. http://dx.doi.org/10.3386/w3627.

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Koster, Tinka, Landry Fanou, Nina Bellini Motovska, Denis Muhangi, Ali Mahamadou, and Cor Wattel. End evaluation of the MFA-NL-supported NCEA programme 2017-2022. Wageningen: Wageningen Economic Research, 2022. http://dx.doi.org/10.18174/578904.

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