Relevant bibliographies by topics / Methylerythritol phosphate pathway (MEP pathway)

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Academic literature on the topic 'Methylerythritol phosphate pathway (MEP pathway)'

Author: Grafiati
Published: 31 August 2024
Last updated: 31 July 2025

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Journal articles on the topic "Methylerythritol phosphate pathway (MEP pathway)"

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Banerjee, A., and T. D. Sharkey. "Methylerythritol 4-phosphate (MEP) pathway metabolic regulation." Nat. Prod. Rep. 31, no. 8 (2014): 1043–55. http://dx.doi.org/10.1039/c3np70124g.

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The methylerythritol 4-phosphate pathway provides precursors for isoprenoids in bacteria, some eukaryotic parasites, and chloroplasts of plants. Metabolic regulatory mechanisms control flux through the pathway and the concentration of a central intermediate, methylerythritol cyclodiphosphate.
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Testa, Charles A., and L. Jeffrey Johnson. "A Whole-Cell Phenotypic Screening Platform for Identifying Methylerythritol Phosphate Pathway-Selective Inhibitors as Novel Antibacterial Agents." Antimicrobial Agents and Chemotherapy 56, no. 9 (2012): 4906–13. http://dx.doi.org/10.1128/aac.00987-12.

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ABSTRACTIsoprenoid biosynthesis is essential for survival of all living organisms. More than 50,000 unique isoprenoids occur naturally, with each constructed from two simple five-carbon precursors: isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Two pathways for the biosynthesis of IPP and DMAPP are found in nature. Humans exclusively use the mevalonate (MVA) pathway, while most bacteria, including all Gram-negative and many Gram-positive species, use the unrelated methylerythritol phosphate (MEP) pathway. Here we report the development of a novel, whole-cell phenotypic sc
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Cassera, María B., Fabio C. Gozzo, Fabio L. D'Alexandri, et al. "The Methylerythritol Phosphate Pathway Is Functionally Active in All Intraerythrocytic Stages ofPlasmodium falciparum." Journal of Biological Chemistry 279, no. 50 (2004): 51749–59. http://dx.doi.org/10.1074/jbc.m408360200.

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Two genes encoding the enzymes 1-deoxy-d-xylulose-5-phosphate synthase and 1-deoxy-d-xylulose-5-phosphate reductoisomerase have been recently identified, suggesting that isoprenoid biosynthesis inPlasmodium falciparumdepends on the methylerythritol phosphate (MEP) pathway, and that fosmidomycin could inhibit the activity of 1-deoxy-d-xylulose-5-phosphate reductoisomerase. The metabolite 1-deoxy-d-xylulose-5-phosphate is not only an intermediate of the MEP pathway for the biosynthesis of isopentenyl diphosphate but is also involved in the biosynthesis of thiamin (vitamin B1) and pyridoxal (vita
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Chen, Lijia, Hui Tong, Mingxuan Wang, et al. "Effect of Enzyme Inhibitors on Terpene Trilactones Biosynthesis and Gene Expression Profiling in Ginkgo biloba Cultured Cells." Natural Product Communications 10, no. 12 (2015): 1934578X1501001. http://dx.doi.org/10.1177/1934578x1501001205.

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The biosynthetic pathway of terpene trilactones of Ginkgo biloba is unclear. In this present study, suspension cultured cells of G. biloba were used to explore the regulation of the mevalonic acid (MVA) and methylerythritol 4-phosphate (MEP) pathways in response to specific enzyme inhibitors (lovastatin and clomazone). The results showed that the biosynthesis of bilobalide was more highly correlated with the MVA pathway, and the biosynthesis of ginkgolides was more highly correlated with the MEP pathway. Meanwhile, according to the results, it could be speculated that bilobalide might be a pro
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Zeidler, J., J. Schwender, C. Mueller, and H. K. Lichtenthaler. "The non-mevalonate isoprenoid biosynthesis of plants as a test system for drugs against malaria and pathogenic bacteria." Biochemical Society Transactions 28, no. 6 (2000): 796–98. http://dx.doi.org/10.1042/bst0280796.

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Two plant test systems are presented in the search for new inhibitors of the non-mevalonate isoprenoid pathway. A derivative of clomazone appears to be an inhibitor of the deoxyxylulose 5-phosphate/methylerythritol 4-phosphate (DOXP/MEP) pathway of isoprenoid formation.
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Kadian, Kavita, Yash Gupta, Harsh Vardhan Singh, Prakasha Kempaiah, and Manmeet Rawat. "Apicoplast Metabolism: Parasite’s Achilles’ Heel." Current Topics in Medicinal Chemistry 18, no. 22 (2019): 1987–97. http://dx.doi.org/10.2174/1568026619666181130134742.

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Malaria continues to impinge heavily on mankind, with five continents still under its clasp. Widespread and rapid emergence of drug resistance in the Plasmodium parasite to current therapies accentuate the quest for novel drug targets and antimalarial compounds. Plasmodium parasites, maintain a non-photosynthetic relict organelle known as Apicoplast. Among the four major pathways of Apicoplast, biosynthesis of isoprenoids via Methylerythritol phosphate (MEP) pathway is the only indispensable function of Apicoplast that occurs during different stages of the malaria parasite. Moreover, the human
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Cornish, Rita M., John R. Roth, and C. Dale Poulter. "Lethal Mutations in the Isoprenoid Pathway of Salmonella enterica." Journal of Bacteriology 188, no. 4 (2006): 1444–50. http://dx.doi.org/10.1128/jb.188.4.1444-1450.2006.

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ABSTRACT Essential isoprenoid compounds are synthesized using the 2-C-methyl-d-erythritol 4-phosphate (MEP) pathway in many gram-negative bacteria, some gram-positive bacteria, some apicomplexan parasites, and plant chloroplasts. The alternative mevalonate pathway is found in archaea and eukaryotes, including cytosolic biosynthesis in plants. The existence of orthogonal essential pathways in eukaryotes and bacteria makes the MEP pathway an attractive target for the development of antimicrobial agents. A system is described for identifying mutations in the MEP pathway of Salmonella enterica ser
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Pérez-Gil, Jordi, and Manuel Rodríguez-Concepción. "Metabolic plasticity for isoprenoid biosynthesis in bacteria." Biochemical Journal 452, no. 1 (2013): 19–25. http://dx.doi.org/10.1042/bj20121899.

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Isoprenoids are a large family of compounds synthesized by all free-living organisms. In most bacteria, the common precursors of all isoprenoids are produced by the MEP (methylerythritol 4-phosphate) pathway. The MEP pathway is absent from archaea, fungi and animals (including humans), which synthesize their isoprenoid precursors using the completely unrelated MVA (mevalonate) pathway. Because the MEP pathway is essential in most bacterial pathogens (as well as in the malaria parasites), it has been proposed as a promising new target for the development of novel anti-infective agents. However,
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Banerjee, Aparajita, Yan Wu, Rahul Banerjee, Yue Li, Honggao Yan, and Thomas D. Sharkey. "Feedback Inhibition of Deoxy-d-xylulose-5-phosphate Synthase Regulates the Methylerythritol 4-Phosphate Pathway." Journal of Biological Chemistry 288, no. 23 (2013): 16926–36. http://dx.doi.org/10.1074/jbc.m113.464636.

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The 2-C-methyl-d-erythritol 4-phosphate (MEP) pathway leads to the biosynthesis of isopentenyl diphosphate (IDP) and dimethylallyl diphosphate (DMADP), the precursors for isoprene and higher isoprenoids. Isoprene has significant effects on atmospheric chemistry, whereas other isoprenoids have diverse roles ranging from various biological processes to applications in commercial uses. Understanding the metabolic regulation of the MEP pathway is important considering the numerous applications of this pathway. The 1-deoxy-d-xylulose-5-phosphate synthase (DXS) enzyme was cloned from Populus trichoc
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Rohmer, M. "Mevalonate-independent methylerythritol phosphate pathway for isoprenoid biosynthesis. Elucidation and distribution." Pure and Applied Chemistry 75, no. 2-3 (2003): 375–88. http://dx.doi.org/10.1351/pac200375020375.

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A long-overlooked metabolic pathway for isoprenoid biosynthesis, the mevalonate-independent methylerythritol phosphate (MEP) pathway, is present in many bacteria and in the chloroplasts of all phototrophic organisms. It represents an alternative to the well known mevalonate pathway, which is present in animals, fungi, plant cytoplasm, archaebacteria, and some eubacteria. This contribution summarizes key steps of its elucidation and the state-of-the-art knowledge of this biosynthetic pathway, which represents a novel target for antibacterial and antiparasitic drugs.
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Dissertations / Theses on the topic "Methylerythritol phosphate pathway (MEP pathway)"

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Bianchino, Gabriella ines. "La métalloenzyme IspH, une source pour la découverte de nouveaux agents antimicrobiens." Electronic Thesis or Diss., Strasbourg, 2024. http://www.theses.fr/2024STRAF016.

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L'un des moyens de lutter contre la résistance aux antimicrobiens est de se concentrer sur des séries d'enzymes cibles sous-exploitées. Dans la plupart des bactéries et certains parasites, les précurseurs isoprénoïdes sont synthétisés par la voie du 2C-méthyl-d-érythritol 4-phosphate (MEP), absente chez l'homme, et qui représente donc une cible intéressante pour le développement de nouveaux anti-infectieux. IspH est une oxydoréductase contenant un cluster [4Fe-4S]2+ sensible à l'oxygène qui catalyse la dernière étape de la voie du MEP en convertissant l’HMBPP en IPP et DMAPP. Une stratégie plu
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Baatarkhuu, Zoljargal. "Metabolic labelling of bacterial isoprenoids produced by the methylerythritol phosphate pathway : a starting point towards a new inhibitor." Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAF029/document.

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Les isoprénoïdes, présents dans tous les organismes vivants, sont synthétisés selon deux processus: la voie du Mevalonate et la voie Méthylérythritol phosphate (MEP). Cette dernière, absente chez l’humain, est très étudiée car elle représente une cible pour le développement de nouveaux antimicrobiens. Le ME-N3, un analogue du méthylérythritol portant un azoture, a été synthétisé et exploité dans des expériences de marquage métabolique de la voie MEP en utilisant un couplage bioorthogonale suivi d’une analyse par LC/MS. De façon intéressante, nous avons découvert que le MEP-N3, un analogue du M
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Henriksson, Lena M. "Structural and Functional Studies of Peptidyl-prolyl cis-trans isomerase A and 1-deoxy-D-xylulose- 5-phosphate reductoisomerase from Mycobacterium tuberculosis." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis Acta Universitatis Upsaliensis, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8253.

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Giménez, Oya Víctor. "Molecular studies of two methylerythritol 4-phosphate pathway enzymes of isoprenoid biosynthesis : the 4-diphosphocytidyl-2C-methyl-D-erythritol kinase and the 1-deoxy-D-xylulose 5-phosphate synthase = Estudios moleculares de dos enzimas de la ruta del metileritritol 4-fosfato de biosíntesis de isoprenoides : la 4-difosfocitidil-2C-metil-D-eritritol quinasa y la 1-dexosi-D-xilulosa 5-fosfato sintasa." Doctoral thesis, Universitat de Barcelona, 2009. http://hdl.handle.net/10803/665005.

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Los isoprenoides son una de las mayores familias de compuestos descritos en la naturaleza. Estos compuestos están presentes en todos los organismos vivos y se sintetizan a partir de dos moléculas de 5 átomos de carbono: el isopentenil difosfato (IPP) y el dimetilalil difosfato (DMAPP). Actualmente se conoce que arqueobacterias, hongos y animales presentan la ruta del mevalonato de síntesis de estos precursores, mientras que eubacterias, algún protozoo (como el causante de la malaria) y protistas presentan la ruta del metileritritol 4-fosfato (MEP) de síntesis de IPP y DMAPP. Estas rutas coexis
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Jansson, Anna M. "Targeting Infectious Disease : Structural and functional studies of proteins from two RNA viruses and Mycobacterium tuberculosis." Doctoral thesis, Uppsala universitet, Struktur- och molekylärbiologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-196623.

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The recent emergence of a number of new viral diseases as well as the re-emergence of tuberculosis (TB), indicate an urgent need for new drugs against viral and bacterial infections. Coronavirus nsp1 has been shown to induce suppression of host gene expression and interfere with host immune response. However, the mechanism behind this is currently unknown. Here we present the first nsp1 structure from an alphacoronavirus, Transmissible gastroenteritis virus (TGEV) nsp1. Contrary to previous speculation, the TGEV nsp1 structure clearly shows that alpha- and betacoronavirus nsp1s have a common e
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Book chapters on the topic "Methylerythritol phosphate pathway (MEP pathway)"

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Lichtenthaler, Hartmut K. "Chapter 7 The Non-mevalonate DOXP/MEP (Deoxyxylulose 5-Phosphate/Methylerythritol 4-Phosphate) Pathway of Chloroplast Isoprenoid and Pigment Biosynthesis." In The Chloroplast. Springer Netherlands, 2010. http://dx.doi.org/10.1007/978-90-481-8531-3_7.

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Boronat, Albert. "Chapter 8 The Methylerythritol 4-Phosphate Pathway: Regulatory Role in Plastid Isoprenoid Biosynthesis." In The Chloroplast. Springer Netherlands, 2010. http://dx.doi.org/10.1007/978-90-481-8531-3_8.

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Sathee, Lekshmy, M. K. Malini, Pramod Kumar, and Sudhir Kumar. "Terpenoid Production Through Mevalonate and Methylerythritol Phosphate Pathway and Regulation of Environmental Stress Tolerance." In Biology and Biotechnology of Environmental Stress Tolerance in Plants. Apple Academic Press, 2023. http://dx.doi.org/10.1201/9781003346173-4.

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Nagegowda, Dinesh A., David Rhodes, and Natalia Dudareva. "Chapter 10 The Role of the Methyl-Erythritol-Phosphate (MEP)Pathway in Rhythmic Emission of Volatiles." In The Chloroplast. Springer Netherlands, 2010. http://dx.doi.org/10.1007/978-90-481-8531-3_10.

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Wright, Louwrance P., and Michael A. Phillips. "Measuring the Activity of 1-Deoxy-D-Xylulose 5-Phosphate Synthase, the First Enzyme in the MEP Pathway, in Plant Extracts." In Methods in Molecular Biology. Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-0606-2_2.

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O. Bruce, Stella, and Felix A. Onyegbule. "Biosynthesis of Natural Products." In Biosynthesis [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.97660.

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Natural products are in the form of primary and secondary metabolites and are isolated chemical compounds or substances from living organisms. Terpenes, Phenolic compounds, and Nitrogen-containing compounds are secondary metabolites. The biosyntheses of secondary metabolites are derived from primary metabolism pathways, which consist of a tricarboxylic acid cycle (TCA), methylerythritol phosphate pathway (MEP), mevalonic and shikimic acid pathway. This chapter provides an overview of the diversity of secondary metabolites in plants, their multiple biological functions, and multi-faceted cultur
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"Mevalonate and Methylerythritol Phosphate Pathways: Terpenoids and Steroids." In Chemical Diversity of Plant Specialized Metabolites. Royal Society of Chemistry, 2023. http://dx.doi.org/10.1039/9781837671472-00077.

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Terpenes are naturally occurring metabolites with structural diversity based on the number of isoprene units (C5H8). They are biosynthesized following mevalonate (MVA) or methylerythritol phosphate (MEP) pathways. The MVA pathway occurs in the cytosol in plants to form sesquiterpenes (C15) and triterpenes (C30). The MEP pathway occurs in the plastids in plants to form monoterpenes (C10), diterpenes (C20) and tetraterpenes (C40). Depending on the structure, metabolites belonging to this group are essential for plants to interact with the environment for example, protecting plants against herbiv
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Bittencourt Fagundes, Mariane, and Roger Wagner. "Sterols Biosynthesis in Algae." In Biosynthesis [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.96719.

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Sterols are secondary metabolites, they are considered bioactive, due to their recognized activity as antioxidants, anticarcinogenic, cardiovascular protectors, and antiviral capacity. These triterpenoids can be found in a wide range of concentrations in different algae strains, being the variations related to external factors. In the world, there are millions of algae, some strains have the ability to produce high-value phytosterols, like stigmasterol, and sitosterol, however, others could lead to cholesterol production. For this reason, understand the principal factors involved in sterols bi
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Rohmer, Michel. "Methylerythritol Phosphate Pathway." In Comprehensive Natural Products III. Elsevier, 2010. http://dx.doi.org/10.1016/b978-0-08-102690-8.00702-8.

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Rohmer, Michel. "Methylerythritol Phosphate Pathway." In Comprehensive Natural Products II. Elsevier, 2010. http://dx.doi.org/10.1016/b978-008045382-8.00702-4.

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