Relevant bibliographies by topics / Methyl transferase

Academic literature on the topic 'Methyl transferase'

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Published: 4 June 2021
Last updated: 31 January 2023

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Journal articles on the topic "Methyl transferase"

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Farid, Anila, Beenish Haider, Kehkashan Akbar, Ammar Mehfooz, Ziyad Ahmad, Fazal E. Raheem, Furqan Arshad, et al. "Homology Modeling of Predicted Methyl Transferases (STY 3264): A Protein of Salmonella TYPHI CT18." Pakistan Journal of Medical and Health Sciences 16, no. 3 (March 26, 2022): 720–22. http://dx.doi.org/10.53350/pjmhs22163720.

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Background: Salmonella typhi gives rise to typhoid fever which is life threatening illness.It puts end to approximately 600,000 people per annum around the world.Food and water are the leading components through which this disease is passed on and becomes origin of typhoid.It lays out widely where cleanliness is very substandard. Objective: To construct 3 dimensional structure of protein Methyl Transferase of Salmonella typhi CT18 by homology modeling. Materials and Methods: Bioinformatic tools and programs like Comprehensive Microbial Resource (CMR), Interproscan, Basic Local Alignment Search Tool (BLAST), Modellor 9.10, Procheck and Prosa were helpful for the complete homology modeling of methyl transferases (STY 3264).The models were visualized by DS Viever. Results: Homology modeling is an effective method to find structure of methyl transferase protein for future discovery of drugs. Conclusion: Homology modeling is an effective method to find structure of protein which provides good solution for drug discovery. Keywords: Methyl transferase ,Homology modeling, Typhoid fever,Salmonella typhi CT18.
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Ibrahim, Ragal K. "Plant O-methyl-transferase signatures." Trends in Plant Science 2, no. 7 (July 1997): 249–50. http://dx.doi.org/10.1016/s1360-1385(97)86345-5.

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Spencer, S. R., L. A. Xue, E. M. Klenz, and P. Talalay. "The potency of inducers of NAD(P)H:(quinone-acceptor) oxidoreductase parallels their efficiency as substrates for glutathione transferases. Structural and electronic correlations." Biochemical Journal 273, no. 3 (February 1, 1991): 711–17. http://dx.doi.org/10.1042/bj2730711.

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Induction of glutathione transferases (EC. 2.5.1.18), NAD(P)H:(quinone-acceptor) oxidoreductase (EC 1.6.99.2; quinone reductase) and other detoxification enzymes is a major mechanism for protecting cells against the toxicities of electrophiles, including many carcinogens. Although inducers of these two enzymes belong to many different chemical classes, they nevertheless contain (or acquire by metabolism) electrophilic centres that appear to be essential for inclusive activity, and many inducers are Michael reaction acceptors [Talalay, De Long & Prochaska (1988) Proc. Natl. Acad. Sci. U.S.A., 85, 8261-8265]. The inducers therefore share structural and electronic features with glutathione transferase substrates. To define these features more precisely, we examined the inductive potencies (by measuring quinone reductase in murine hepatoma cells) of two types of glutathione transferase substrates: a series of 1-chloro-2-nitrobenzenes bearing para-oriented electron-donating or -withdrawing substituents and a wide variety of other commonly used and structurally unrelated glutathione transferase substrates. We conclude that virtually all glutathione transferase substrates are inducers, and their potencies in the nitrobenzene series correlate linearly with the Hammett sigma or sigma- values of the aromatic substituents, precisely as previously reported for their efficiencies as glutathione transferase substrates. More detailed information on the electronic requirements for inductive activity was obtained with a series of methyl trans-cinnamates bearing electron-withdrawing or -donating substituents on the aromatic ring, and in which the electronic densities at the olefinic and adjacent carbon atoms were measured by 13C n.m.r. Electron-withdrawing meta-substituents markedly enhance inductive potency in parallel with their increased non-enzymic reactivity with GSH. Thus, methyl 3-bromo-, 3-nitro- and 3-chloro-cinnamates are 21, 14 and 8 times more potent inducers than the parent methyl cinnamate. This finding permits the design of more potent inducers, which are important for elucidation of the molecular mechanisms of induction.
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Nes, W. "Sterol methyl transferase: enzymology and inhibition." Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1529, no. 1-3 (December 15, 2000): 63–88. http://dx.doi.org/10.1016/s1388-1981(00)00138-4.

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Futó, J., J. E. Cannon, M. R. Fahey, C. F. Seals, J. P. Kupferberg, R. D. Miller, and J. Moss. "VECURONIUM INHIBITS HISTAMINE N-METHYL TRANSFERASE." Anesthesia & Analgesia 67, Supplement (February 1988): 67. http://dx.doi.org/10.1213/00000539-198802001-00067.

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SUGUMARAN, Geetha, Maya KATSMAN, and E. Jeremiah SILBERT. "Subcellular co-localization and potential interaction of glucuronosyltransferases with nascent proteochondroitin sulphate at Golgi sites of chondroitin synthesis." Biochemical Journal 329, no. 1 (January 1, 1998): 203–8. http://dx.doi.org/10.1042/bj3290203.

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Microsomal membranes from chick embryo epiphyseal cartilage were fractionated by equilibrium sucrose-density-gradient centrifugation and assayed for GlcA (glucuronic acid) transferase I (the enzyme that transfers GlcA from UDP-GlcA to Gal-Gal-Xyl of proteochondroitin linkage region), for comparison with GlcA transferase II (the GlcA transferase of chondroitin polymerization). Gal(β1-3)Galβ1-methyl (disaccharide) and GalNAc(β1-4)GlcA(β1-3)GalNAc(β1-4)GlcA(β1-3)GalNAc (pentasaccharide) were used respectively as acceptors of [14C]GlcA from UDP-[14C]GlcA. Distributions of the two GlcA transferase activities in the sucrose-density-gradient fractions were compared with each other and with the previously reported distribution of the activities of Gal transferases (UDP-Gal to ovalbumin, and to xylose of the proteochondroitin linkage region) and GalNAc (N-acetylgalactosamine) transferase II of chondroitin polymerization. The linkage-region GlcA transferase I had a dual Golgi distribution similar to that of chondroitin-polymerizing GlcA transferase II and distinctly different from the distribution of linkage-region Gal transferases I and II, which were found exclusively in the heavier fractions. Solubilized GlcA transferase I was partly purified by sequential use of Q-Sepharose, heparin-Sepharose and wheatgerm agglutinin-agarose and was accompanied at each step by some of the GlcA transferase II activity. Both GlcA transferase I and II bound to the Q-Sepharose as though they were highly anionic. However, treatment with chondroitin ABC lyase eliminated the binding while markedly decreasing enzyme stability. The enzyme activities could not be reconstituted by adding chondroitin or chondroitin pentasaccharide to the chondroitin ABC lyase-treated enzymes. Incubation of the partly purified enzymes with both UDP-GlcA and UDP-GalNAc resulted in a 40-fold greater incorporation than with just one sugar nucleotide, indicating the presence of bound, nascent proteochondroitin serving as the acceptor for chondroitin polymerization. These results, together with the membrane co-localization, indicate that GlcA transferase I and GlcA transferase II occur closely together with nascent proteochondroitin at the site of synthesis and that this complex with the nascent proteochondroitin stabilizes both enzymes during purification.
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Pacifici, GM, P. Donatelli, and L. Giuliani. "Histamine N-methyl transferase: inhibition by drugs." British Journal of Clinical Pharmacology 34, no. 4 (October 1992): 322–27. http://dx.doi.org/10.1111/j.1365-2125.1992.tb05637.x.

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Bruce, C., and W. H. Taylor. "Fluoride - An Activator of Histamine Methyl Transferase." Clinical Science 93, s37 (August 1, 1997): 17P. http://dx.doi.org/10.1042/cs093017p.

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Acuna-Johnson, Adriana P., Allan C. Oehlschlager, Aldona M. Pierce, Harold D. Pierce, and Eva K. Czyzewska. "Stereochemistry of yeast Δ24-sterol methyl transferase." Bioorganic & Medicinal Chemistry 5, no. 5 (May 1997): 821–32. http://dx.doi.org/10.1016/s0968-0896(97)00010-2.

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Pitt, James J., Nicholas Tzanakos, and Thanh Nguyen. "Newborn screening for guanidinoacetate methyl transferase deficiency." Molecular Genetics and Metabolism 111, no. 3 (March 2014): 303–4. http://dx.doi.org/10.1016/j.ymgme.2014.01.005.

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Dissertations / Theses on the topic "Methyl transferase"

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Pandya, Bhavna Kalpesh. "Thiopurine s-methyl transferase gene polymorphism : Clinical correlations." Thesis, University of Manchester, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.529233.

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Jiang, Hong, and 姜紅. "Effects of estrogen on human catechol-O-methyl transferase." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B31241864.

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Jiang, Hong. "Effects of estrogen on human catechol-O-methyl transferase." Hong Kong : University of Hong Kong, 2001. http://sunzi.lib.hku.hk/hkuto/record.jsp?B23273744.

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Holford, Kenneth C. Borst David Wellington. "Molecular characterization of farnesoic acid o-methyl transferase in the American lobster (Homarus americanus)." Normal, Ill. Illinois State University, 2000. http://wwwlib.umi.com/cr/ilstu/fullcit?p9986727.

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Thesis (Ph. D.)--Illinois State University, 2000.
Title from title page screen, viewed May 11, 2006. Dissertation Committee: David Borst (chair), Anthony Otsuka, Radheshyam Jayaswal, Paul Garris, David Williams. Includes bibliographical references (leaves 130-135) and abstract. Also available in print.
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Hahn, Eric [Verfasser]. "Der Einfluss des Val158/108Met Polymorphismus der Catechol-O-Methyl-Transferase auf behaviorale Inhibition bei Schizophrenie / Eric Hahn." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2011. http://d-nb.info/1025510348/34.

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Salvidge, William. "The role of the histone methyl-transferase, set1, in variable gene expression and cell type proportioning in D. discoideum." Thesis, University of Manchester, 2018. https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-the-histone-methyltransferase-set1-in-variable-gene-expression-and-cell-type-proportioning-in-d-discoideum(d3d7ea3b-7f44-4f8a-ab65-b7d36a295604).html.

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During multicellular development, cells must make fate decisions that reproducibly generate the correct cell type proportions. It is remarkable that in certain developmental scenarios, seemingly identical cells in a homogenous environment can achieve this. It is thought that this is possible because cell populations exhibit reproducible cell-cell variation in gene expression. How these differences are generated has been intensely studied over the past decade, with transcriptional bursting emerging as an important factor for driving variability between cells. Furthermore, it is thought that chromatin structure around gene promoters is a key regulator of transcriptional bursting. However, key questions remain. What factors regulate chromatin structure at the molecular level? Is the activity of chromatin regulators governed by random processes or entrained by one of many hidden factors such as cell cycle positioning, cell volume, metabolism? Are the proportions of cells exhibiting different bursting patterns regulated to ensure normal cell fate choice and proportioning? To address these questions, we have investigated whether different regulators of chromatin structure affect the pre-stalk/pre-spore fate decision in the social amoebae D. discoideum. We have identified that set1, a methyl-transferase responsible for generating methylation on histone 3 at position lysine 4 (H3K4me), plays a key role in controlling the balance of cell types in multicellular development as in its absence cells become autonomously primed towards a pre-stalk fate. Single cell RNA-sequencing has revealed that genes normally regulated by this modification represent a specific class of hyper-variable genes. We find that this variability is generated by specific set1 dependent repression at these loci, as upon deletion of this enzyme we see an active recruitment of more cells to an expressing state. Our data suggest that set1 activity itself is controlled by the external source of the cell cycle. This cell cycle dependent regulation robustly ensures the correct proportions of cells within the population contain levels of set1 activity that prime 25% of cells towards the pre-stalk lineage and the other 75% to the pre-spore fate. As such we believe our study reveals a novel mechanism linking specific regulation of transcriptional bursting through the activity of set1 to cell fate propensity.
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Esberard, Barbara Cathalá. "Polimorfismos do gene da tiopurina metiltransferase (TPMT) em pacientes com doenças inflamatórias intestinais: avaliação da prevalência e correlação com efeitos colaterais." Universidade do Estado do Rio de Janeiro, 2013. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=6947.

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A azatioprina e a 6 mercaptopurina (6-MCP) são drogas muito utilizada no tratamento das doenças inflamatórias intestinais (DII), porém estão associadas a vários efeitos colaterais. A determinação prévia do genótipo da tiopurina metiltransferase (TPMT) pode identificar pacientes de maior risco de toxicidade a droga. Os objetivos deste estudo foram avaliar a prevalência dos polimorfismos do gene da TPMT em pacientes com DII acompanhados no Hospital Universitário Pedro Ernesto (HUPE) da UERJ, comparando com a prevalência em outras populações e correlacionar a presença desses polimorfismos com a toxicidade às drogas. Foram avaliados 146 pacientes com doença de Crohn (DC) e 73 com retocolite ulcerativa idiopática (RCUI). A pesquisa dos principais genótipos da TPMT (*2, *3, *3C) foi realizada por técnicas de PCR (alelo específico e RFLP). Os achados clínicos foram correlacionados com a genotipagem e avaliados por análises multivariadas. Dentre os pacientes que estavam em uso de azatioprina, 14 apresentaram pancreatite ou elevação de enzimas pancreáticas, 6 apresentaram hepatoxicidade e 2 evoluíram com neutropenia. Os polimorfismos do gene da TPMT foram observados em 37 dos 219 pacientes (8 foram heterozigotos para o genótipo *2, 11 heterozigotos para *3A e 18 foram heterozigotos para o polimorfismo *3C). Não foi observado nenhum homozigoto polimórfico. Uma correlação positiva foi observada entre a elevação de enzimas pancreáticas e os genótipos *2 e *3C. A prevalência dos polimorfismos neste estudo (16,89%) foi maior que a descrita para população caucasiana e em outros estudos brasileiros. Apesar do predomínio do genótipo *3C, não houve ocorrência exclusiva de um polimorfismo, conforme observado em outras populações. A população brasileira devido à sua miscigenação têm características genotípicas próprias diferentes do outros países do mundo. Dois polimorfismos da TPMT (*2 e *3C) estiveram associados à toxicidade ao uso da azatioprina em pacientes com DII no sudeste do Brasil. O teste genético pode auxiliar na escolha da melhor droga e na dose ideal para os pacientes portadores de DII antes do início do tratamento.
Although azathioprine is commonly used for treating patients with inflammatory bowel disease (IBD), there is still concern about potential severe side effects. Determining the Thiopurine-Methyl-Transferase (TPMT) genotype is expected to identify patients predisposition in respect of toxicity prior to azathioprine administration. The aim of this study was to analyze the prevalence of TPMT genotypes and association with drug toxicity in IBD patients from south-eastern Brazil, constituted by a heterogeneous population. We analyzed 146 Crohns disease (CD) and 73 ulcerative colitis (UC) patients, for the presence of the major TPMT genetic variants (TPMP*2, *3A, *3C) by means of specific allele and RFLP PCR. Clinical data were systematically recorded and correlated with the genotype results, and analyzed in multivariate models. Among the side effects recorded from patients taking azathioprine, 14 presented pancreatitis and/or elevation of pancreatic enzymes, while 6 had liver toxicity, and 2 had neutropenia. TPMT polymorphisms were detected in 37/219 patients (8 heterozygous for *2, 11 heterozygous for *3A and 18 heterozygous for *3C). No homozygotic polymorphisms were found. A positive correlation was found between the elevation of pancreatic enzymes and either TPMT*2 or TPMT*3C. The prevalence of polymorphisms in this study (16,89%) was greater than described with caucasian population or other Brazilian studies. Despite the prevalence of genotype *3C, it was not the only polymorphism shown as observed in other populations. Two genetic variants of TPMT gene (*2 and *3C) are associated with azathioprine toxicity in IBD patients from a south-eastern Brazilian population. Genetic testing may help in the selection of the most appropriate medication prior to treatment initiation.
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Zhang, Rui. "Association study of adverse events with monoamine oxidase inhibitors and catechol-o-methyl transferase inhibitors in subjects with Parkinson's disease." Thesis, Boston University, 2012. https://hdl.handle.net/2144/31630.

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Thesis (M.A.)--Boston University
PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.
Introduction: Parkinson's disease (PO) is a neurodegenerative disorder. Medication is by far the most effective and important treatment for PO and levodopa is the most effective and commonly used medicine to control motor symptoms in PD. However, its long-term usage often induces several adverse events (AEs). Both combination therapy of monoamine oxidase type B inhibitor. (MAOBI) with levodopa and catechol-0-methyltransferase inhibitor (COMTI) with levodopa were demonstrated to provide benefits to PO patients, such as regulating motor fluctuations and reducing levodopa dose, but are accompanied by increased frequency of dopaminergic AEs. Available data is too limited to directly compare the safety of these combination therapies (MAOBI vs. COMTI). Thus the aim of this study is to investigate whether MAOBI and COMTI have different AE profiles. Methods: All the data used to analyze the AEs of different PO medications were retrieved from "The Boston University Medical Center's Parkinson's Disease and Movement Disorder Database". Ten categories of AEs, i.e. compulsive behavior, dyskinesia, dementia, depression, freezing, hallucinations, motor fluctuations, orthostatic hypotension, other autonomic dysfunction and psychosis, were compared between MAOBI and COMTI groups. Fisher's exact test and multivariable logistic regression models were applied to analyze data. Results: In total 87 subjects were included in the analysis. Out of 10 AEs, presence of dementia was significantly different between the MAOBI and COMTI groups with OR of 6.9 (COMTI vs. MAOBI, 95%CI: 1.3-37.0). Motor fluctuations were also found to be differently distributed in the two medication groups with OR of 3.1 (COMTI vs. MAOBI, 95%CI: 1.0-9.8). Conclusion: COMTI combined with levodopa therapy was more likely to be associated with dementia and motor fluctuations than MAOBI. The results need to be further tested in other independent studies.
2031-01-01
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Jacobs, Sarah. "Development of a COMT PCR multiplex to investigate resilience, anxiety and childhood trauma in a South African population." University of the Western Cape, 2020. http://hdl.handle.net/11394/7923.

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>Magister Scientiae - MSc
Anxiety, resilience and childhood trauma can be categorized as functional behavioural categories, with a wealth of research behind each. The research approach adopted for each, in most cases, is either from a genetic or neuropsychological standpoint, with few studies combining both to better understand all three functional behavioural categories as a multidimensional construct A number of candidate genes have been identified as markers for anxiety, resilience and childhood trauma, of which Catechol-methyl-transferase (COMT) and several respective single nucleotide polymorphisms (SNPs) are included. Although COMT SNPs have been linked to at least one of the functional categories, with a handful of haplotypes identified, to our knowledge no study has investigated the combination of SNPs selected for this study (rs6269, rs4818, rs4680, rs4633, rs737865, rs2075507) as a possible haplotype, specifically in a South African population. The use of SNaPshot for the genotyping of genes is an efficient and reliable means of identifying genotype frequencies and haplotypes in large sample groups, yet when selecting more than two SNPs of interest, the development of a multiplex assay is ideal. The first aim of the study was to design and optimize a multiplex assay to genotype several COMT SNPs. The primer design, multiplex optimization and SNaPshot conditions used showed good working parameters that can be utilized and further improved by optimization. Self-report measures are widely used to measure psychiatric disorders, such as anxiety, and has also been used for the measurement of resilience and childhood trauma. With each functional behavioural category well investigated in its respective domain, there is a need to investigate all three as a collective in a South African population due to the high rate of anxiety and childhood trauma exposure in communities. The second aim of the study was to investigate the prevalence of anxiety, resilience and childhood as functional behavioural categories in the full South African sample group; and the role of sex, through established self-report measures and respective normative data. Additionally, this carried over into investigating the correlation between anxiety, resilience and childhood trauma as a multidimensional construct in both the full South African sample and between sexes. There is a clear relationship which exists between all three functional behavioural categories, as they show a correlation in various dimensions independent of one another. Higher anxiety levels amongst females were reported, with no difference between sexes for resiliency. The empirical data collected from both COMT SNP and self-report measures for male and female where explored and reviewed against current literature for better understanding and insight into the association of COMT SNPs with anxiety, resilience and childhood trauma in a South African population. The results of this study to understand the complexity and association of all three functional behavioural categories as a multidimensional construct will be invaluable and may assist in the identification of possible risk factors which are essential for the promotion of better mental health in society.
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Thomas, Sherine Elizabeth. "Targeting Mycobacterium abscessus infection in cystic fibrosis : a structure-guided fragment-based drug discovery approach." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/289126.

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Recent years have seen the emergence of Mycobacterium abscessus, a highly drug-resistant non-tuberculous mycobacterium, which causes life-threatening infections in people with chronic lung conditions like cystic fibrosis. This opportunistic pathogen is refractory to treatment with standard anti-tuberculosis drugs and most currently available antibiotics, often resulting in accelerated lung function decline. This project aims to use a structure-guided fragment-based drug discovery approach to develop effective drugs to treat M. abscessus infections. During the early stage of the project, three bacterial targets were identified, based on analysis of the structural proteome of M. abscessus and prior knowledge of M. tuberculosis drug targets, followed by gene knockout studies to determine target essentiality for bacterial survival. The three targets from M. abscessus were then cloned, expressed and purified and suitable crystallization conditions were identified leading to the determination of high resolution structures. Further, a large number of starting fragments that hit the three target proteins were determined, using a combination of biophysical screening methods and by defining crystal structures of the complexes. For target 3, PPAT (Phosphopantethiene adenylyl transferase), a chemical linking of two fragments followed by iterative fragment elaboration was carried out to obtain two compounds with low micromolar affinities in vitro. However, these compounds afforded only low inhibitory activity on M. abscessus whole cell. All starting fragments of target 2, PurC (SAICAR synthase), occupied the ATP indole pocket. Efforts were then made to identify further fragment hits by screening diverse libraries. Sub-structure searches of these initial fragment hits and virtual screening helped to identify potential analogues amenable to further medicinal chemistry intervention. While fragment hits of target 1, TrmD (tRNA-(N1G37) methyl transferase), were prioritized, whereby two chemical series were developed using fragment growing and merging approaches. Iterative fragment elaboration cycle, aided by crystallography, biophysical and biochemical assays led to the development of several potential lead candidates having low nano-molar range of in vitro affinities. Two such compounds afforded moderate inhibition of M. abscessus and stronger inhibition of M. tuberculosis and S. aureus cultures. Further chemical modifications of these compounds as well as others are now being done, to optimize cellular and in vivo activities, to be ultimately presented as early stage clinical candidates.
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Books on the topic "Methyl transferase"

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Horn, M. A. Method for estimating water use and interbasin transfers of freshwater and wastewater in an urbanized basin. Northborough, Mass: U.S. Dept. of the Interior, U.S. Geological Survey, 2000.

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Horn, M. A. Method for estimating water use and interbasin transfers of freshwater and wastewater in an urbanized basin. Northborough, Mass: U.S. Dept. of the Interior, U.S. Geological Survey, 2000.

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Adam, Thomas. Intercultural transfers and the making of the modern world, 1800-2000: Sources and contexts. Houndmills, Basingstoke, Hampshire: Palgrave Macmillan, 2012.

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Intercultural transfers and the making of the modern world, 1800-2000: Sources and contexts. Houndmills, Basingstoke, Hampshire: Palgrave Macmillan, 2012.

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Paulter, Nicholas G. Guide to the technologies of concealed weapon and contratband imaging and detection. Washington, DC: U.S. Dept. of Justice, Office Justice Programs, National Institute of Justice, 2001.

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Jordan, Robert B. Reaction Mechanisms of Inorganic and Organometallic Systems. Oxford University Press, 2007. http://dx.doi.org/10.1093/oso/9780195301007.001.0001.

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This third edition retains the general level and scope of earlier editions, but has been substantially updated with over 900 new references covering the literature through 2005, and 140 more pages of text than the previous edition. In addition to the general updating of materials, there is new or greatly expanded coverage of topics such as Curtin-Hammett conditions, pressure effects, metal hydrides and asymmetric hydrogenation catalysts, the inverted electron-transfer region, intervalence electron transfer, photochemistry of metal carbonyls, methyl transferase and nitric oxide synthase. The new chapter on heterogeneous systems introduces the basic background to this industrially important area. The emphasis is on inorganic examples of gas/liquid and gas/liquid/solid systems and methods of determining heterogeneity.
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Hamilton, Matthew Lloyd. COMT genotypes in pain responses. Edited by Paul Farquhar-Smith, Pierre Beaulieu, and Sian Jagger. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198834359.003.0080.

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The landmark study discussed in this chapter is ‘COMT val158met genotype affects μ‎-opioid neurotransmitter responses to a pain stressor’, published by Zubieta et al. in 2003. Catechol-O-methyl-transferase (COMT) is a key modulator of dopaminergic and noradrenergic neurotransmission. This study focused on a single nucleotide polymorphism of the COMT gene encoding the substitution of valine (val) by methionine (met) at Codon 158 (val158met), resulting in a three- to fourfold reduction in its activity. Individuals with the val/val genotype have the highest activity of COMT, val/met genotypes have intermediate activity, and met/met genotypes have the lowest activity of COMT. Using a mixture of PET imaging of the binding of μ‎-opioid receptors and correlation with clinical outcomes, this groundbreaking study provided evidence that confirmed their hypothesis and established the COMT val158met SNP as one of the first gene modifications with direct ramifications on human pain.
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Buller, Ana Maria, Amber Peterman, Meghna Ranganathan, Alexandra Bleile, Melissa Hidrobo, and Lori Heise. A Mixed-Method Review of Cash Transfers and Intimate Partner Violence in Low- and Middle-Income Countries. Published by Oxford University Press on behalf of the World Bank, 2018. http://dx.doi.org/10.1596/33274.

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Rubin, Donald, Xiaoqin Wang, Li Yin, and Elizabeth Zell. Bayesian causal inference: Approaches to estimating the effect of treating hospital type on cancer survival in Sweden using principal stratification. Edited by Anthony O'Hagan and Mike West. Oxford University Press, 2018. http://dx.doi.org/10.1093/oxfordhb/9780198703174.013.24.

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This article discusses the use of Bayesian causal inference, and more specifically the posterior predictive approach of Rubin’s causal model (RCM) and methods of principal stratification, in estimating the effects of ‘treating hospital type’ on cancer survival. Using the Karolinska Institute in Stockholm, Sweden, as a case study, the article investigates which type of hospital (large patient volume vs. small volume) is superior for treating certain serious conditions. The study examines which factors may reasonably be considered ignorable in the context of covariates available, as well as non-compliance complications due to transfers between hospital types for treatment. The article first provides an overview of the general Bayesian approach to causal inference, primarily with ignorable treatment assignment, before introducing the proposed approach and motivating it using simple method-of-moments summary statistics. Finally, the results of simulation using Markov chain Monte Carlo (MCMC) methods are presented.
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Jolivet, Jean-Pierre. Metal Oxide Nanostructures Chemistry. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780190928117.001.0001.

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This much-anticipated new edition of Jolivet's work builds on the edition published in 2000. It is entirely updated, restructured and increased in content. The book focuses on the formation by techniques of green chemistry of oxide nanoparticles having a technological interest. Jolivet introduces the most recent concepts and modelings such as dynamics of particle growth, ordered aggregation, ionic and electronic interfacial transfers. A general view of the metal hydroxides, oxy-hydroxides and oxides through the periodic table is given, highlighting the influence of the synthesis conditions on crystalline structure, size and morphology of nanoparticles. The formation of aluminum, iron, titanium, manganese and zirconium oxides are specifically studied. These nanomaterials have a special interest in many technological fields such as ceramic powders, catalysis and photocatalysis, colored pigments, polymers, cosmetics and also in some biological or environmental phenomena.
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Book chapters on the topic "Methyl transferase"

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Schomburg, Dietmar, and Ida Schomburg. "methyl halide transferase 2.1.1.165." In Class 2–3.2 Transferases, Hydrolases, 9–19. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-36240-8_3.

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Strauss, Bernard, Daphna Sagher, Theodore Karrison, Jeffrey Schwartz, Richard Larson, and Stephanie Williams. "Methyl Transferase Activity in Secondary Leukemia." In DNA Damage and Repair in Human Tissues, 277–89. Boston, MA: Springer US, 1990. http://dx.doi.org/10.1007/978-1-4613-0637-5_22.

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Lim, Siew Pheng, Christophe Bodenreider, and Pei-Yong Shi. "Detection and Quantification of Flavivirus NS5 Methyl-Transferase Activities." In Antiviral Methods and Protocols, 249–68. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-484-5_20.

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Peter, H., S. Deutschmann, A. Muelle, B. Gansewendt, M. Bolt, and E. Hallier. "Different Affinity of Erythrocyte Glutathione-S-Transferase to Methyl Chloride in Humans." In Archives of Toxicology, 128–32. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74117-3_17.

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Brouwer, C., J. J. Keizer-Garritsen, L. H. J. Lambooy, K. Ament, P. G. J. H. Ter Riet, R. A. De Abreu, J. P. M. Bökkerink, et al. "Thiopurine Methyl Transferase: Activity and Genotyping in Patients with Acute Lymphoblastic Leukemia." In Purine and Pyrimidine Metabolism in Man X, 327–31. Boston, MA: Springer US, 2002. http://dx.doi.org/10.1007/0-306-46843-3_63.

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Castro, Carmen, Andrew P. Breksa, Elizabeth M. Salisbury, and Timothy A. Garrow. "Betaine-Homocysteine S-Methyl-Transferase (BHMT) Transcription is Inhibited by S-Adenosylmethionine (AdoMet)." In Chemistry and Biology of Pteridines and Folates, 549–56. Boston, MA: Springer US, 2002. http://dx.doi.org/10.1007/978-1-4615-0945-5_93.

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Talas Ogras, T., A. Kuru, and N. GÖZÜKirmizi. "Lignin Pathway Modifications by Antisense O-Methyl- Transferase and Peroxidase Gene Construct in Tobacco." In Progress in Botanical Research, 541–44. Dordrecht: Springer Netherlands, 1998. http://dx.doi.org/10.1007/978-94-011-5274-7_124.

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Nuno Palma, P., László E. Kiss, and Patrício Soares-da-Silva. "CHAPTER 4. Catechol‐O‐Methyl‐Transferase Inhibitors: Present Problems and Relevance of the New Ones." In Drug Discovery, 83–109. Cambridge: Royal Society of Chemistry, 2013. http://dx.doi.org/10.1039/9781849737357-00083.

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Backliwal, Gaurav, Markus Hildinger, Ivan Küttel, David L. Hacker, and Florian M. Wurm. "Optimization and Comparison of Different DNA Methyl Transferase and Histone Deacetylase Inhibitors for Enhancing Transient Protein Expression." In Cells and Culture, 261–64. Dordrecht: Springer Netherlands, 2010. http://dx.doi.org/10.1007/978-90-481-3419-9_45.

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de Andrade, Alexander, Augusto Tulmann Neto, Fernando Adami Tcacenco, Rubens Marschalek, Adriana Pereira, Antonio Mendes de Oliveira Neto, Klaus Konrad Scheuermann, Ester Wickert, and José Alberto Noldin. "Gamma-rays in the development of rice lines tolerant to aryloxyphenoxypropionate herbicides." In Mutation breeding, genetic diversity and crop adaptation to climate change, 285–89. Wallingford: CABI, 2021. http://dx.doi.org/10.1079/9781789249095.0029.

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Abstract The aryloxyphenoxypropionate (APP) herbicides are graminicides with excellent control of many grass weed species, including weedy rice (Oryza sativa L.). These herbicides block fatty acid biosynthesis by inhibition of the enzyme acetyl-CoA carboxylase (ACCase) and cause death of the plant. Through induced mutation of rice seeds with gamma-rays, rice lines resistant to APP have been developed. Plant dose-response assays confirmed resistance to the APP herbicides quizalofop-p-ethyl and haloxyfop-p-methyl. The carboxyl-transferase (CT) domain fragments of ACCase from the resistant line and the susceptible control were sequenced and compared. A point mutation was detected in the amino acid position 2027. Results indicated that resistance to APP herbicides is a consequence of an altered ACCase enzyme that confers resistance. APP-resistant rice provides an option to improve the efficiency of weed management in rice crops.
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Conference papers on the topic "Methyl transferase"

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Wroblewski, Tadeusz H., Philip D. Tatman, Anthony R. Fringuello, Samuel S. Scherer, William B. Foreman, Denise M. Damek, Kevin Lillehei, et al. "DNA Methyl Transferase Inhibition in Meningiomas." In 31st Annual Meeting North American Skull Base Society. Georg Thieme Verlag KG, 2022. http://dx.doi.org/10.1055/s-0042-1743634.

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Mueller, Daniel, Christian Beisenherz-Huss, Carolin Heidemann-Dinger, Constance Ketterer, Diane Krämer, and Michael H. G. Kubbutat. "Abstract 5160: Development of a non-radioactive method to determine Protein-Methyl-Transferase activity in-vitro." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-5160.

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Forester, Sarah C., and Joshua D. Lambert. "Abstract 5435: Tolcapone inhibits catechol-O-methyl transferase-mediated methylation of (-)-epigallocatechin-3-gallatein vivo." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-5435.

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Arora, Shilpi, Vidya Balasubramanian, Kaylyn Williamson, Victor Gehling, Chris Nasveschuk, Rishi Vaswani, Jennifer Busby, et al. "Abstract 5526: Inhibition of the histone methyl transferase EZH2 causes viability defects in multiple myeloma." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-5526.

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Göbel, Gero, Anja Talke, Uwe Ahnert, and Fred Lisdat. "Sensorial activity determination of the human catechol-O-methyl transferase at fluorine doped tin oxide." In The 1st International Electronic Conference on Biosensors. Basel, Switzerland: MDPI, 2020. http://dx.doi.org/10.3390/iecb2020-07077.

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Licht, Jonathan D. "Abstract IA27: Deregulation and oncogenic functions of the NSD2/MMSET histone methyl transferase in hematologic malignancies." In Abstracts: Second AACR Conference on Hematologic Malignancies: Translating Discoveries to Novel Therapies; May 6-9, 2017; Boston, MA. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1557-3265.hemmal17-ia27.

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Konduri, Santhi D., Sreeram Maddipatla, Joshua Smith, Beth Isley, Maria-Lourdes M. Caparas, Susan M. Constantino, Nikita Shah, and Said Baidas. "Abstract 716: O6-Methylguanine DNA methyl transferase (MGMT) and tamoxifen resistance in patients with breast cancer." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-716.

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Daifuku, Richard. "NUC041: a Prodrug of the DNA Methyl Transferase Inhibitor (DNMTI) and Ribonucleotide Reductase Inhibitor NUC013." In 3rd International Electronic Conference on Medicinal Chemistry. Basel, Switzerland: MDPI, 2017. http://dx.doi.org/10.3390/ecmc-3-04666.

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Ezponda-Itoiz, Teresa, Relja Popovic, Mrinal Y. Shah, Eva Martinez-Garcia, Dong-Joon Min, Christine Will, and Jonathan D. Licht. "Abstract 1046: The histone methyl transferase MMSET/WHSC1 promotes an epithelial-mesenchymal transition and invasive properties of prostate cancer." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-1046.

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Puyo, Stéphane, Jacques Robert, Pierre Richaud, Philippe Pourquier, and Nadine Houédé. "Abstract 2692: Overexpression of serine hydroxy methyl transferase 2 (SHMT2) in high grade prostate cancers as a marker of tumor response to oxaliplatin." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-2692.

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Reports on the topic "Methyl transferase"

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Vigneri, Marcella. The Science in the Middle: Middle Level Theory in International Development Evaluation. Centre of Excellence for Development Impact and Learning, 2021. http://dx.doi.org/10.51744/cmwp3.

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This paper discusses how Middle Level Theory is becoming an important tool in the evaluation of international development programmes by connecting abstract theory to project level theory. The paper discusses three defining features of how mid-level theorising generates transferable knowledge across disciplines and settings; it consolidates empirical regularities in human behaviour, it explains the diversity of outcomes observed across contexts, and it is explicit about causal principles observed in different settings. These attributes are illustrated using examples from interventions in international development that show the potential of the method in improving the design of international development programmes.
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Mader, Philip, Maren Duvendack, Adrienne Lees, Aurelie Larquemin, and Keir Macdonald. Enablers, Barriers and Impacts of Digital Financial Services: Insights from an Evidence Gap Map and Implications for Taxation. Institute of Development Studies, June 2022. http://dx.doi.org/10.19088/ictd.2022.008.

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Digital financial services (DFS) have expanded rapidly over the last decade, particularly in sub-Saharan Africa. They have been accompanied by claims that they can alleviate poverty, empower women, help businesses grow, and improve macroeconomic outcomes and government effectiveness. As they have become more widespread, some controversy has arisen as governments have identified DFS revenues and profits as potential sources of tax revenue. Evidence-based policy in relation to taxing DFS requires an understanding of the enablers and barriers (preconditions) of DFS, as well as the impacts of DFS. This report aims to present insights from an Evidence Gap Map (EGM) on the enablers and barriers, and subsequent impacts, of DFS, including any research related to taxation. An EGM serves to clearly identify the gaps in the evidence base in a visually intuitive way, allowing researchers to address these gaps. This can help to shape future research agendas. Our EGM draws on elements from the systematic review methodology. We develop a transparent set of inclusion criteria and comprehensive search strategy to identify relevant studies, and assess the confidence we can place in their causal findings. An extensive search initially identified 389 studies, 205 of which met the inclusion criteria and were assessed based on criteria of cogency, transparency and credibility. We categorised 40 studies as high confidence, 97 as medium confidence, and 68 as low confidence. We find that the evidence base is still relatively thin, but growing rapidly. The high-confidence evidence base is dominated by quantitative approaches, especially experimental study designs. The geographical focus of many studies is East Africa. The dominant DFS intervention studied is mobile money. The majority of studies focus on DFS usage for payments and transfers; fewer studies focus on savings, very few on credit, and none on insurance. The strongest evidence base on enablers and barriers relates to how user attributes and industry structure affect DFS. Little is known about how policy and politics, including taxation, and macroeconomic and social factors, affect DFS. The evidence base on impacts is strongest at the individual and household level, and partly covers the business level. The impact of DFS on the macroeconomy, and the meso level of industry and government, is very limited. We find no high-confidence evidence on the role of taxation. We need more higher quality evidence on a variety of topics. This should particularly look at enablers, constraints and impacts, including the role of taxation, beyond the individual and household level. Research going forward should cover more geographic areas and a wider range of purposes DFS can serve (use cases), including savings, and particularly credit. More methodological variety should be encouraged – experiments can be useful, but are not the best method for all research questions.
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Method for estimating water use and interbasin transfers of freshwater and wastewater in an urbanized basin. US Geological Survey, 2000. http://dx.doi.org/10.3133/wri994287.

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