Relevant bibliographies by topics / Metabolomic analyses / Dissertations / Theses
To see the other types of publications on this topic, follow the link: Metabolomic analyses.

Dissertations / Theses on the topic 'Metabolomic analyses'

Author: Grafiati
Published: 25 June 2022
Last updated: 31 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'Metabolomic analyses.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Robinson, Andrew Raymond. "Metabolomic analyses of wood attributes in tree species." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/7697.

Full text
Abstract:
Metabolomics is an emerging field in functional plant biology that attempts to relate patterns in the molecular intermediates and products of metabolic pathways with genetic, gene expression, environmental and phenotypic traits - at the whole-tissue and/or whole-organism level. There is enormous potential for metabolomics tools to be applied in the study of tree species, and the demand for widespread application is promoting an ongoing evolution and refinement of newly-developed techniques. This body of research addresses the application of broad-scale, non-targeted metabolomics to questions
APA, Harvard, Vancouver, ISO, and other styles
2

Hobani, Yahya Hasan. "Metabolomic analyses of Drosophila models for human renal disease." Thesis, University of Glasgow, 2012. http://theses.gla.ac.uk/3222/.

Full text
Abstract:
Inborn errors of metabolism (IEMs) constitute a major class of genetic disorder. Most of IEMs are transmitted recessively, so consanguinity has a huge impact on disease prevalence, particularly in societies like Saudi Arabia, where consanguineous marriage is common. Understanding and treatment are very important in genetic diseases, and simple models would be helpful. Thus, the feasibility of applying the fruit fly, Drosophila melanogaster, as a model for a human renal genetic disease - xanthinuria - was investigated. Xanthinuria is a rare human genetic disease, caused by mutations in xanthine
APA, Harvard, Vancouver, ISO, and other styles
3

Wibom, Carl. "Multivariate analyses of proteomic and metabolomic patterns in brain tumors." Doctoral thesis, Umeå universitet, Onkologi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-25670.

Full text
Abstract:
Glioblastoma multiforme (GBM) is the most common primary brain tumor. Given the current standard of care, the prognosis for patients diagnosed with this disease is still poor. There consequently exists a need to improve current treatments, as well as to develop new ones. Many obstacles however need to be overcome to facilitate this effort and one of these involves the development of improved methods to monitor treatment effects. At present, the effects of treatment are typically assessed by radiological means several months after its initiation, which is unsatisfactory for a fast growing tumor
APA, Harvard, Vancouver, ISO, and other styles
4

Taraboletti, Alexandra Anna. "Chemical and Metabolomic Analyses of Cuprizone-Induced Demyelination and Remyelination." University of Akron / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=akron1498535047689141.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Barberis, Elettra. "New non-invasive approaches for proteomics and metabolomics analyses." Doctoral thesis, Università del Piemonte Orientale, 2020. http://hdl.handle.net/11579/115041.

Full text
Abstract:
Recent technological developments in analytical chemistry spurred the analysis of historical, archaeological and paleontological objects. The Identification of proteins and small molecules from cultural heritage objects is crucial to characterize the materials used by the artists and it can provide invaluable information for designing restoration interventions. All most the developed analytical procedures require at least a micro sampling from the object. However, non-invasive techniques are always preferred for the analysis of precious and unique objects. A part of this PhD research focused
APA, Harvard, Vancouver, ISO, and other styles
6

Orland, Annika [Verfasser]. "Metabolomic and Transcriptomic Analyses in the Characterization of Herbal Substances and their Preparations = Metabolom- und Transkriptom-Analysen zur Charakterisierung von pflanzlichen Substanzen und daraus hergestellten Zubereitungen / Annika Orland." Bonn : Universitäts- und Landesbibliothek Bonn, 2014. http://d-nb.info/1077290357/34.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Vincent, Isabel May. "Using metabolomic analyses to study mode of action of and resistance to Eflornithine in Trypanosoma brucei." Thesis, University of Glasgow, 2011. http://theses.gla.ac.uk/3125/.

Full text
Abstract:
Human African trypanosomiasis (HAT) is a disease that is in desperate need of new pharmacological agents active against the causative parasite, the flagellated protozoan Trypanosoma brucei. In this thesis, new metabolomics techniques have been developed to study pathways in response to drug action with the aim of defining the mode of action of current and future drugs. Eflornithine, a polyamine pathway inhibitor, was used as a proof of principle, revealing both expected changes that correlate well with the literature and unexpected changes that lead to pathways and metabolites not previously d
APA, Harvard, Vancouver, ISO, and other styles
8

Sun, Jihan. "Hepatocellular carcinoma complicating MASLD : metabolomic, lipidomic and gene expression analyses of tumorous and non-tumorous liver." Electronic Thesis or Diss., Besançon, Université Marie et Louis Pasteur, 2025. http://www.theses.fr/2025PAST3001.

Full text
Abstract:
Le carcinome hépatocellulaire (CHC) peut compliquer une hépatopathie chronique d'origine virale, alcoolique ou une stéatopathie métabolique (MASLD), une affection qui touche 25 % de la population mondiale et dont l'incidence augmente. Bien que le CHC se développe habituellement en cas de cirrhose, 25 à 30 % des patients atteints de CHC sur MASLD (CHC-MASLD) ne présentent aucune fibrose ou une fibrose légère, ce qui suggère que différents mécanismes de cancérogénèse sont impliqués dans le CHC-MASLD. Notre étude s'est concentrée sur les analyses de lipidomiques et d'expression génique entre les
APA, Harvard, Vancouver, ISO, and other styles
9

Boudah, Samia. "Développement et application de méthodes de chromatographie liquide couplées à la spectrométrie de masse à haute résolution pour les analyses métabolomiques et lipidomiques de larges cohortes." Thesis, Paris 6, 2014. http://www.theses.fr/2014PA066281/document.

Full text
Abstract:
Le profilage métabolomique global de matrices biologiques dans de larges séries d'échantillon est un enjeu majeur. Dans ce contexte, notre travail vise à développer des approches LC-HRMS et outils bioinformatiques pour les analyses métabolomique et lipidomique de larges cohortes. Dans un premier temps, nous avons développé puis évalué la pertinence de 4 méthodes LC-HRMS dans l'annotation du métabolome/lipidome sérique humain. Ainsi, une base de données spectrales a été implémentée à l'aide de spectres MS, MS/MS et les temps de rétention de composés de référence afin d'assurer l'annotation de j
APA, Harvard, Vancouver, ISO, and other styles
10

Díaz, San Pedro Ramón. "Potential of LC-(Q)TOF MS in target and non-target analyses: wide scope screening of organic contaminants and metabolomic applications." Doctoral thesis, Universitat Jaume I, 2016. http://hdl.handle.net/10803/669026.

Full text
Abstract:
En la presente tesis se ha investigado el potencial de la cromatografía líquida acoplada a la espectrometría de masas de alta resolución en aproximaciones analíticas tanto de tipo target (análisis de compuestos diana) como non-target (análisis no dirigido). Las ventajas que este tipo de instrumentación ofrece, derivadas de la adquisición del espectro completo con alta resolución y medidas de masa exacta, la hacen idónea para el screening de contaminantes orgánicos así como para estudios metabolómicos tanto de denominación de origen de alimentos como de carácter biomédico. El trabajo present
APA, Harvard, Vancouver, ISO, and other styles
11

Conan, Cécile. "Metabolomics investigations of seaweed extracts used as plant growth biostimulants and transcriptomic studies of their physiological effects on A. thaliana." Electronic Thesis or Diss., Paris 6, 2016. http://www.theses.fr/2016PA066760.

Full text
Abstract:
Développer une agriculture durable et respectueuse de l’environnement, implique l’utilisation de biostimulants tels que les extraits de macro-algues marines dans le but d’améliorer la croissance des plantes ainsi que leur tolérance aux stress biotiques et abiotiques. Ces extraits commerciaux d’algues sont utilisés en agriculture afin de favoriser la nutrition des plantes, d’améliorer leur qualité nutritionnelle et d’accroitre leur rendement. Dans ce domaine quelques modes d’action ont été élucidés par le centre R&D des Laboratoires Goëmar-Arysta. Cependant, jusqu’à présent, les matières ac
APA, Harvard, Vancouver, ISO, and other styles
12

Karimpour, Masoumeh. "Multi-platform metabolomics assays to study the responsiveness of the human plasma and lung lavage metabolome." Doctoral thesis, Umeå universitet, Kemiska institutionen, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-120591.

Full text
Abstract:
Metabolomics as a field has been used to track changes and perturbations in the human body by investigating metabolite profiles indicating the change of metabolite levels over time and in response to different challenges. In this thesis work, the main focus was on applying multiplatform-metabolomics to study the human metabolome following exposure to perturbations, such as diet (in the form of a challenge meal) and exhaust emissions (air pollution exposure in a controlled setting). The cutting-edge analytical platforms used for this purpose were nuclear magnetic resonance (NMR), as well as gas
APA, Harvard, Vancouver, ISO, and other styles
13

Zhang, Baichen. "Dissection of phloem transport in cucurbitaceae by metabolomic analysis." Phd thesis, Universität Potsdam, 2005. http://opus.kobv.de/ubp/volltexte/2006/664/.

Full text
Abstract:
This thesis aimed to investigate several fundamental and perplexing questions relating to the phloem loading and transport mechanisms of <i>Cucurbita maxima</i>, by combining metabolomic analysis with cell biological techniques. This putative symplastic loading species has long been used for experiments on phloem anatomy, phloem biochemistry, phloem transport physiology and phloem signalling. Symplastic loading species have been proposed to use a polymer trapping mechanism to accumulate RFO (raffinose family oligosaccharides) sugars to build up high osmotic pressure in minor veins which sustai
APA, Harvard, Vancouver, ISO, and other styles
14

Yu, Zhonghao. "Metabolomics analyses to better understand complex phenotypes." Diss., Ludwig-Maximilians-Universität München, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:19-172737.

Full text
Abstract:
In dieser Doktorarbeit werden drei Metabolomics-Studien der KORA Kohorte behandelt. Das Ziel dieser Doktorarbeit war, ein besseres Verständnis der Rolle des Metabolismus von komplexen Phänotypen anhand von Unterschieden im Blutbild, des Geschlechts und anhand von Veränderungen des Metabolitenprofils bei multifaktoriellen Krankheiten wie Typ 2 Diabetes mellitus zu erhalten. Um Artefakte auszuschließen wurden strikte Qualitätskontrollen aller gemessenen Metaboliten durchgeführt. Durch die Analyse von Blutplasma und -serum von 377 Personen konnten wir zeigen, dass die Konzentrationen der Metabol
APA, Harvard, Vancouver, ISO, and other styles
15

Hällkvist, Jenny. "Investigation of parameters causing drift in metabolomic analyzes." Thesis, Umeå universitet, Kemiska institutionen, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-85837.

Full text
APA, Harvard, Vancouver, ISO, and other styles
16

Yet, Idil. "Integrated epigenomics and metabolomics analysis in twins." Thesis, King's College London (University of London), 2016. https://kclpure.kcl.ac.uk/portal/en/theses/integrated-epigenomics-and-metabolomics-analysis-in-twins(4d0fb76b-cc2b-4e31-8950-a7ffb5b91363).html.

Full text
Abstract:
Epigenetics and metabolomics are rapidly growing areas of research, in part due to recent advances in technology that have allowed for a wide coverage of the human genome. Metabolites are small compounds present in cell and body fluids, and are involved in biochemical processes of the cell. Quantitative trait loci associated with levels of individual metabolites (mQTLs) have been identified from numerous metabolome GWAS. Here, I analysed metabolite levels in twins with the aim of identifying genetic variants that influence metabolomic traits (mQTLs) using two different metabolomics platforms,
APA, Harvard, Vancouver, ISO, and other styles
17

BACCOLO, GIACOMO. "Chemometrics approaches for the automatic analysis of metabolomics GC-MS data." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2022. http://hdl.handle.net/10281/374731.

Full text
Abstract:
La metabolomica, che consiste nella identificazione di tutti i metaboliti presenti all’interno dei campioni biologici analizzati, è un approccio ampiamente applicato in diversi campi di ricerca quali: identificazione di biomarcatori, sviluppo di nuovi farmaci, scienze alimentari e ambientali. La metabolomica è strettamente legata alla capacità di tecniche analitiche fra queste una delle più applicate è la gas cromatografia accoppiata alla spettrometria di massa. Moderne piattaforme analitiche possono generare centinaia di migliaia di spettri, rilevando una quantità impressionante di molecole d
APA, Harvard, Vancouver, ISO, and other styles
18

Muhamad, Ali Howbeer. "Metabolomics investigation of microbial cell factories." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/metabolomics-investigation-of-microbial-cell-factories(2e2f5f58-d38a-4c77-966b-56ce92aec619).html.

Full text
Abstract:
The stream of new technological advancements and their integration into the field of microbiology have contributed significantly towards our understanding of life in the micro-scale world, making the fields of microbiology and biotechnology shine like never before. Since 1980, the recombinant protein-based therapeutics industry has become one of the fastest growing sectors in the biopharmaceutical market. Nearly 30% of commercially available recombinant proteins are produced in Escherichia coli, making this species one of the most commonly used bacterial expression systems for the production o
APA, Harvard, Vancouver, ISO, and other styles
19

Waterman, Claire Louise. "A global metabolomic based analysis of non-genotoxic carcinogenesis." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611571.

Full text
APA, Harvard, Vancouver, ISO, and other styles
20

D'Souza, Arun. "PathCaseMAW: A Workbench for Metabolomic Analysis." Case Western Reserve University School of Graduate Studies / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1222895452.

Full text
APA, Harvard, Vancouver, ISO, and other styles
21

D'Souza, Arun. "PathCase [superscript] MAW a workbench for metabolomic analysis institution /." online version, 2009. http://rave.ohiolink.edu/etdc/view.cgi?acc%5Fnum=case1222895452.

Full text
APA, Harvard, Vancouver, ISO, and other styles
22

Kumar, Y. "Proteomic and metabolomic analysis of chickpea‐fusarium oxysporum interactions." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2015. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2002.

Full text
APA, Harvard, Vancouver, ISO, and other styles
23

Spicer, Rachel. "Fit for purpose? : a metascientific analysis of metabolomics data in public repositories." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/287634.

Full text
Abstract:
Metabolomics is the study of metabolites and metabolic processes. Due to the diversity of structures and polarities of metabolites, no single analytical technique is able to measure the entire metabolome - instead a varied set of experimental designs and instrumental technologies are used to measure specific portions. This has led to the development of many distinct data analysis and processing methods and software. There is hope that metabolomics can be utilized for clinical applications, in toxicology and to measure the exposome. However, for these applications to be realised data must be hi
APA, Harvard, Vancouver, ISO, and other styles
24

Breier, Michaela [Verfasser], Jerzy [Akademischer Betreuer] [Gutachter] Adamski, and Hannelore [Gutachter] Daniel. "Targeted metabolomics analyses reveal the impact of pre-analytics and drug intake on the human metabolome / Michaela Breier ; Gutachter: Hannelore Daniel, Jerzy Adamski ; Betreuer: Jerzy Adamski." München : Universitätsbibliothek der TU München, 2015. http://d-nb.info/1138359653/34.

Full text
APA, Harvard, Vancouver, ISO, and other styles
25

Beisken, Stephan Andreas. "Informatics for tandem mass spectrometry-based metabolomics." Thesis, University of Cambridge, 2014. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708325.

Full text
APA, Harvard, Vancouver, ISO, and other styles
26

Green, Cara. "Multi-tissue metabolomic analysis of responses to graded calorie restriction." Thesis, University of Aberdeen, 2017. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=235895.

Full text
Abstract:
With ageing comes a deterioration of metabolic and physiological changes that often manifest themselves as age-related comorbidities. Calorie restriction (CR) is a robust intervention that can prevent and reverse such changes, resulting in reduced ageassociated disease and increased lifespan across a wide range of species. Moreover, a link between the extent of restriction and increased lifespan has also been established. Though widely studied, the mechanisms behind the beneficial effects of CR have yet to be fully understood. Consequently, I investigated metabolomic changes in the liver, plas
APA, Harvard, Vancouver, ISO, and other styles
27

Guy, Alison Jane. "Machine perfusion in kidney transplantation : clinical application & metabolomic analysis." Thesis, University of Birmingham, 2015. http://etheses.bham.ac.uk//id/eprint/6395/.

Full text
Abstract:
Kidney Transplantation is the gold standard treatment for patients with end-stage renal failure. Most kidneys used for transplantation are from deceased donors and ensuring successful outcomes depends on many factors. One of these is organ storage. Hypothermic Machine Perfusion (HMP) of deceased donor organs has been shown to have several benefits. However, it has not been widely adopted and the underlying mechanism is poorly understood. The first section of this thesis examines the introduction of HMP into clinical practice. HMP outcomes were similar to those of standard storage techniques bu
APA, Harvard, Vancouver, ISO, and other styles
28

Emamzadeh, Yazdi Simin. "Metabolomic analysis on anti-HIV activity of selected Helichrysum species." Thesis, University of Pretoria, 2019. http://hdl.handle.net/2263/77900.

Full text
Abstract:
Since the beginning of human civilization, medicinal plants have been used to treat a variety of infectious and non-infectious diseases. The therapeutic properties of phytochemicals have been recognized since ancient human history. The genus Helichrysum Mill. with its attractive flowers consist of an estimated 500‒600 species in the Asteraceae family. In South Africa and Namibia there are about 244‒250 species with tremendous morphological diversity. Several Helichrysum species are widely used by the indigenous population to treat various disorders such as wounds, infections, respiratory condi
APA, Harvard, Vancouver, ISO, and other styles
29

Kelly, Benjamin J. "Computational Analysis of Metabolomic Toxicological Data Derived from NMR Spectroscopy." Wright State University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=wright1240245664.

Full text
APA, Harvard, Vancouver, ISO, and other styles
30

Křápková, Monika. "Dynamický model produkce polyhydroxyalkonoátů termofilní bakterií S. thermodepolymerans." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2021. http://www.nusl.cz/ntk/nusl-442582.

Full text
Abstract:
Tato diplomová práce se zabývá rekonstrukcí dynamického modelu produkce polyhydroxyalkanoátů (PHA) termofilní bakterií Schlegelella thermodepolymerans. První kapitola poskytuje čtenářům krátký úvod do systémové biologie a matematické teorie grafů. Na ni navazuje druhá kapitola zabývající se různými přístupy v dynamickém modelování, včetně běžně používaných nástrojů pro dynamickou analýzu komplexních systémů. Třetí kapitola pak sleduje další pojmy a možnosti týkající se analýzy modelu. Následující kapitola se zaměřuje na metabolomiku a často používané laboratorní techniky a pátá kapitola je pak
APA, Harvard, Vancouver, ISO, and other styles
31

PIRAS, CRISTINA. "Metabolomic investigation of food matrices by ¹H NMR spectroscopy." Doctoral thesis, Università degli Studi di Cagliari, 2012. http://hdl.handle.net/11584/266182.

Full text
Abstract:
The present Ph.D. work shows some applications on the NMR-based metabolomic approach in food science. The investigated food matrices are largely different, from a manufactured product that undergoes only physical treatments (bottarga), to a manufactured product where biochemical transformations take place (Fiore Sardo cheese), and, finally, a raw food (Argentina sphyraena). All of these food matrices were not chosen by chance, but they represent an important piece of economy of the island of Sardinia, or might be further valorized, gaining more importance in the near future. Indeed, bottarga a
APA, Harvard, Vancouver, ISO, and other styles
32

Davis, Richard. "Analysis of pattern recognition techniques applied to 1H NMR metabolomic data." Thesis, University of York, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.490269.

Full text
Abstract:
Metabolomics seeks to achieve a comprehensive quantitative analysis of the wide range of metabolites in biological samples. Analytical chemistry, and specifically 1H NMR, can provide spectra detailing the vast array of physio-chemical properties of the sample. The identification of characteristics in the spectra is known as metabolomic fingerprinting. However, the thousands of variables in the 1H NMR spectra, .relating to hundreds of metabolites, make the data sets extremely complex and difficult to interpret. The aim of this research was to develop analytical techniques to classify biological
APA, Harvard, Vancouver, ISO, and other styles
33

Hervás, Marín David. "Use of multivariate statistical methods for the analysis of metabolomic data." Doctoral thesis, Universitat Politècnica de València, 2019. http://hdl.handle.net/10251/130847.

Full text
Abstract:
[ES] En las últimas décadas los avances tecnológicos han tenido como consecuencia la generación de una creciente cantidad de datos en el campo de la biología y la biomedicina. A día de hoy, las así llamadas tecnologías "ómicas", como la genómica, epigenómica, transcriptómica o metabolómica entre otras, producen bases de datos con cientos, miles o incluso millones de variables. El análisis de datos ómicos presenta una serie de complejidades tanto metodoló-gicas como computacionales que han llevado a una revolución en el desarrollo de nuevos métodos estadísticos específicamente diseñados para t
APA, Harvard, Vancouver, ISO, and other styles
34

Gummer, Joel. "A metabolomic analysis of G-protein signalling mutants of Stagonospora nodorum." Thesis, Gummer, Joel (2012) A metabolomic analysis of G-protein signalling mutants of Stagonospora nodorum. PhD thesis, Murdoch University, 2012. https://researchrepository.murdoch.edu.au/id/eprint/17286/.

Full text
Abstract:
Stagonospora nodorum is the causal agent of Stagonospora nodorum blotch (SNB) of wheat. This fungus has cost the Australian grains industry upwards of 100 million dollars (AUD) p.a. in recent growing seasons, making it one of the most agriculturally damaging pathogens in Australia. Disease severity is governed by the polycyclic lifecycle of S. nodorum, requiring a succession of spore inoculum arising from the asexual fruiting body of the fungus, known as the pycnidium. The resultant fungal density will determine the level of damage and ultimately influence the grain yield of the plant. G-p
APA, Harvard, Vancouver, ISO, and other styles
35

Klünder, Christina. "Metabolomics for toxicity analysis using the chlorophyte Scenedesmus vacuolatus /." Leipzig [u.a.], 2009. http://www.ufz.de/data/ufzdiss_2_2009_9947.pdf.

Full text
APA, Harvard, Vancouver, ISO, and other styles
36

Gloaguen, Yoann. "Supporting analysis, visualisation and biological interpretation of metabolomics datasets." Thesis, University of Glasgow, 2017. http://theses.gla.ac.uk/8433/.

Full text
Abstract:
Over the past decades, the emerging omics technologies have enabled scientists to take a step further in the investigation of biological systems. From food safety to stratified medicine, omics technologies are now an essential and powerful means to study biological processes. Omics technologies are however at different stages of maturity, and the most recent field of the omics family, metabolomics, is still in its infancy. Metabolomics attempts to catalogue, characterise and quantify all small molecules constitutive of a biological system. Liquid Chromatography - Mass Spectrometry (LCMS) is no
APA, Harvard, Vancouver, ISO, and other styles
37

Abdelrazig, Salah M. A. "Mass spectrometry for high-throughput metabolomics analysis of urine." Thesis, University of Nottingham, 2015. http://eprints.nottingham.ac.uk/30600/.

Full text
Abstract:
Direct electrospray ionisation-mass spectrometry (direct ESI-MS), by omitting the chromatographic step, has great potential for application as a high-throughput approach for untargeted urine metabolomics analysis compared to liquid chromatography-mass spectrometry (LC-MS). The rapid development and technical innovations revealed in the field of ambient ionisation MS such as nanoelectrospray ionisation (nanoESI) chip-based infusion and liquid extraction surface analysis mass spectrometry (LESA-MS) suggest that they might be suitable for high-throughput metabolomics analysis. In this thesis, LC-
APA, Harvard, Vancouver, ISO, and other styles
38

Singh, P. "Metabolomics and camphor biosynthetic pathway analysis of ocimum killmandscharicum." Thesis(Ph.D.), CSIR - National Chemical Laboratory, Pune, 2016. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/5833.

Full text
APA, Harvard, Vancouver, ISO, and other styles
39

Heyman, Heino Martin. "Metabolomic comparison of selected Helichrysum species to predict their antiviral properties." Diss., University of Pretoria, 2009. http://hdl.handle.net/2263/26565.

Full text
Abstract:
From the Helichrysum genus 600 species occur in Africa of which 244 species are found in South Africa. The most commonly used Helichrysum species for medicinal purposes are H. cymosum, H. odoratissimum, H. petiolare and H. nudifolium. The medicinal uses include the treatment of coughs, colds, fever, infection, headaches, menstrual pain and are very popular for wound dressing. Previous published research has shown that H. aureonitens has antiviral properties against Herpes simplex virus type 1 (HSV-1). In this study, further investigation into the Helichrysum species was undertaken, to establis
APA, Harvard, Vancouver, ISO, and other styles
40

Lin, Hui-Ming. "Metabolomic analysis of the interleukin-10-deficient mouse model of Crohn's disease." Thesis, University of Auckland, 2009. http://hdl.handle.net/2292/5793.

Full text
Abstract:
Crohn’s disease is an inflammatory disorder of the bowel, arising from the dysregulation of intestinal mucosal immunity. The interleukin-10-deficient (IL10-/-) mouse develops intestinal inflammation with similar characteristics to Crohn’s disease, due to the loss of immune tolerance towards intestinal microbiota. Metabolomic analysis is the study of small molecule metabolites, involving the measurement of large numbers of metabolites in biological samples. The aim of the research was to study the urinary metabolite profile of IL10-/- mice by gas chromatography-mass spectrometry metabolomic ana
APA, Harvard, Vancouver, ISO, and other styles
41

Kanani, Harin H. "High-throughput time-series metabolomic analysis of a systematically perturbed plant system." College Park, Md. : University of Maryland, 2007. http://hdl.handle.net/1903/6895.

Full text
Abstract:
Thesis (Ph. D.) -- University of Maryland, College Park, 2007.<br>Thesis research directed by: Chemical Engineering. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.
APA, Harvard, Vancouver, ISO, and other styles
42

Rusilowicz, Martin James. "Computational tools for the processing and analysis of time-course metabolomic data." Thesis, University of York, 2016. http://etheses.whiterose.ac.uk/18295/.

Full text
Abstract:
Modern, high-throughput techniques for the acquisition of metabolomic data, combined with an increase in computational power, have provided not only the need for, but also the means to develop and use, methods for the interpretation of large and complex datasets. This thesis investigates the methods by which pertinent information can be extracted from nontargeted metabolomic data and reviews the current state of chemometric methods. The analysis of real-world data and research questions relevant to the agri-food industry reveals several problems for which novel solutions are proposed. Three LC
APA, Harvard, Vancouver, ISO, and other styles
43

Macleod, D. "Differential networks (and other statistical issues) for the analysis of metabolomic data." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2017. http://researchonline.lshtm.ac.uk/3817570/.

Full text
Abstract:
Coronary heart disease (CHD) is the leading cause of death in the UK. Recent technological advances in metabolomics have the potential to contribute to further the understanding of CHD, especially because they are facilitating the collection of metabolomics data in large observational studies. However, the high dimensionality of this type of information and its strong interdependencies raise several analytical difficulties. These difficulties were investigated, motivated by the study of 228 metabolites acquired from blood samples as part of the British Womens Heart and Health Study (BWHHS). Is
APA, Harvard, Vancouver, ISO, and other styles
44

Palisi, Angelica. "NMR-based metabolomic analysis of biological fluids to monitor relevant unsolved diseases." Doctoral thesis, Universita degli studi di Salerno, 2017. http://hdl.handle.net/10556/2565.

Full text
Abstract:
2015 - 2016<br>Metabolomics and metabonomics encompass the comprehensive profiling of multiple metabolite concentrations and their cellular and systemic fluctuations in response to drugs, diet, lifestyle, environment, stimuli and genetic modulations, in order to characterize the beneficial and adverse effects of such interactions. In the context of biomedical applications, metabolomics will have a preferential role with respect to the other "Omics" sciences for its ability to detect in real time the response of the organisms to pathological stressors. The application of the NMR technique
APA, Harvard, Vancouver, ISO, and other styles
45

Duffy, Kate I. "Application of metabolomics to the analysis of ancient organic residues." Thesis, University of Birmingham, 2015. http://etheses.bham.ac.uk//id/eprint/5670/.

Full text
Abstract:
The grape is arguably one of the oldest cultivated products in human history and the analysis of its main product, wine, reveals clues to trade and associations of previous civilizations. In ancient times, wine was stored in clay amphorae, which, if not properly sealed with resin or pitch allowed the wine to wick into clay matrices, dry, and polymerize producing insoluble, intractable materials that may remain within the matrix for several thousand years. Presently, identification of wine residue is based upon the extraction of these polymeric materials from the ceramic matrix and analyzing/id
APA, Harvard, Vancouver, ISO, and other styles
46

Vallabhaneni, Prashanthi. "Metabolomic approaches to understanding the auxin and ethylene response in Arabidopsis roots." Thesis, Virginia Tech, 2012. http://hdl.handle.net/10919/76838.

Full text
Abstract:
Non-targeted metabolite profiling by liquid chromatography-mass spectrometry (LC-MS) was used to determine the metabolite responses of Arabidopsis roots to auxin or ethylene. Crosstalk between these hormones regulates many important physiological processes in plants, including the initiation of lateral root formation and the response to gravity. These occur in part through alterations in the levels of flavonoids, specialized plant metabolites that have been shown to act as negative regulators of auxin transport. However, much remains to be learned about auxin and ethylene responses at the le
APA, Harvard, Vancouver, ISO, and other styles
47

Johnsson, Anna. "Mining for Lung Cancer Biomarkers in Plasma Metabolomics Data." Thesis, Linköping University, Biotechnology, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-57670.

Full text
Abstract:
<p>Lung cancer is the cancer form that has the highest mortality worldwide and inaddition the survival of lung cancer is very low. Only 15% of the patients are alivefive years from set diagnosis. More research is needed to understand the biologyof lung cancer and thus make it possible to discover the disease at an early stage.Early diagnosis leads to an increased chance of survival. In this thesis 179 lungcancer- and 116 control samples of blood serum were analyzed for identificationof metabolomic biomarkers. The control samples were derived from patients withbenign lung diseases.Data was gain
APA, Harvard, Vancouver, ISO, and other styles
48

Graham, S. E. "Metabolomic and statistical analysis of wheat (T Aestivum L) and selected beef tissues." Thesis, Queen's University Belfast, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.517286.

Full text
APA, Harvard, Vancouver, ISO, and other styles
49

Yusuf, Shamil. "Triggers and substrates in atrial fibrillation : an in-depth proteomic and metabolomic analysis." Thesis, University of London, 2009. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.518118.

Full text
APA, Harvard, Vancouver, ISO, and other styles
50

Yu, Zhonghao [Verfasser], and Thomas [Akademischer Betreuer] Illig. "Metabolomics analyses to better understand complex phenotypes / Zhonghao Yu. Betreuer: Thomas Illig." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2013. http://d-nb.info/1060005603/34.

Full text
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the bibliographies on the topic 'Metabolomic analyses' for other source types:
Journal articles Books
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography