Log in

Relevant bibliographies by topics / Metabolic derangements / Journal articles

Journal articles on the topic 'Metabolic derangements'

To see the other types of publications on this topic, follow the link: Metabolic derangements.

Author: Grafiati

Published: 10 December 2022

Last updated: 28 January 2023

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Metabolic derangements.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Allan, Russell, and Cristopher Foster. "Problem-Based Review: A patient with metabolic acidosis." Acute Medicine Journal 11, no. 4 (October 1, 2012): 251–56. http://dx.doi.org/10.52964/amja.0587.

Full text

Abstract:

Metabolic acidosis is a common metabolic derangement present in the acute medical patient. A thorough and structured investigative approach is required as there are many causes and management is reliant on identifying these. In particular calculation of the anion gap with correction for albumin level and use of the delta ratio can be helpful in complex cases especially in patients where a combination of metabolic derangements may be present.

APA, Harvard, Vancouver, ISO, and other styles

2

Gaboury, Cynthia L., Norman K. Hollenberg, Paul N. Hopkins, Roger Williams, and Gordon H. Williams. "Metabolic derangements in nonmodulating hypertension*." American Journal of Hypertension 8, no. 9 (September 1995): 870–75. http://dx.doi.org/10.1016/0895-7061(95)00160-q.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Pinder, Elizabeth M., Gurprit S. S. Atwal, Abraham A. Ayantunde, Sarah Khan, Mike Sokal, Tom McCulloch, and Simon L. Parsons. "Tumour Lysis Syndrome Occurring in a Patient with Metastatic Gastrointestinal Stromal Tumour Treated with Glivec (Imatinib Mesylate, Gleevec, STI571)." Sarcoma 2007 (2007): 1–5. http://dx.doi.org/10.1155/2007/82012.

Full text

Abstract:

Tumour lysis syndrome (TLS) is a rare side effect of chemotherapy for solid tumours. It describes the metabolic derangements following rapid and extensive tumour cell death following a good response to chemotherapy. Symptoms are those of metabolic derangement and renal failure. Treatment involves rehydration and correction of metabolic abnormalities. TLS should be considered in high risk groups. We report a case of TLS in a patient with metastatic gastrointestinal stromal tumour treated with imatinib mesylate. To our knowledge, this is the first reported case.

APA, Harvard, Vancouver, ISO, and other styles

4

Muoio, Deborah M., and Christopher B. Newgard. "Obesity-Related Derangements in Metabolic Regulation." Annual Review of Biochemistry 75, no. 1 (June 2006): 367–401. http://dx.doi.org/10.1146/annurev.biochem.75.103004.142512.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Puente-Maestu, Luis, Alberto Lázaro, and Blanca Humanes. "Metabolic derangements in COPD muscle dysfunction." Journal of Applied Physiology 114, no. 9 (May 1, 2013): 1282–90. http://dx.doi.org/10.1152/japplphysiol.00815.2012.

Full text

Abstract:

Mitochondrial muscle alterations are common in patients with chronic obstructive pulmonary disease (COPD) and manifest mainly as decreased oxidative capacity and excessive production of reactive oxygen species (ROS). The significant loss of oxidative capacity observed in the quadriceps of COPD patients is mainly due to reduced mitochondrial content in the fibers, a finding consistent with the characteristic loss of type I fibers observed in that muscle. Decreased oxidative capacity does not directly limit maximum performance; however, it is associated with increased lactate production at lower exercise intensity and reduced endurance. Since type I fiber atrophy does not occur in respiratory muscles, the loss of such fibers in the quadriceps could be to the result of disuse. In contrast, excessive production of ROS and oxidative stress are observed in both the respiratory muscles and the quadriceps of COPD patients. The causes of increased ROS production are not clear, and a number of different mechanisms can play a role. Several mitochondrial alterations in the quadriceps of COPD patients are similar to those observed in diabetic patients, thus suggesting a role for muscle alterations in this comorbidity. Amino acid metabolism is also altered. Expression of peroxisome proliferator-activated receptor-γ coactivator-1α mRNA is low in the quadriceps of COPD patients, which could also be a consequence of type I fiber loss; nevertheless, its response to exercise is not altered. Patterns of muscle cytochrome oxidase gene activation after training differ between COPD patients and healthy subjects, and the profile is consistent with hypoxic stress, even in nonhypoxic patients.

APA, Harvard, Vancouver, ISO, and other styles

6

Gebreegziabher, Yohannes, Amgad N. Makaryus, John N. Makaryus, and Samy I. McFarlane. "Heart failure: metabolic derangements and therapeutic rationale." Expert Review of Cardiovascular Therapy 5, no. 2 (March 2007): 331–43. http://dx.doi.org/10.1586/14779072.5.2.331.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Yadav, Hariom. "Whole Grains in Amelioration of Metabolic Derangements." Journal of Nutritional Health & Food Science 4, no. 4 (October 24, 2016): 1–11. http://dx.doi.org/10.15226/jnhfs.2016.00173.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Mazzoccoli, Gianluigi, Calogero Longhitano, and Manlio Vinciguerra. "Cardio-Hepatic Metabolic Derangements and Valproic Acid." Current Clinical Pharmacology 9, no. 2 (April 2014): 165–70. http://dx.doi.org/10.2174/1574884708999140101144839.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Baker, Susan S., Ellen Dwyer, and Patt Queen. "Metabolic Derangements in Children Requiring Parenteral Nutrition." Journal of Parenteral and Enteral Nutrition 10, no. 3 (May 1986): 279–81. http://dx.doi.org/10.1177/0148607186010003279.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Govindarajan, Gurushankar, Melvin R. Hayden, Shawna A. Cooper, Said Daibes Figueroa, Lixin Ma, Timothy J. Hoffman, Craig S. Stump, and James R. Sowers. "Metabolic Derangements in the Insulin‐Resistant Heart." American Journal of Geriatric Cardiology 15, no. 6 (November 2006): 102–6. http://dx.doi.org/10.1111/j.1559-4564.2006.05683.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Mizock, Barry A. "METABOLIC DERANGEMENTS IN SEPSIS AND SEPTIC SHOCK." Critical Care Clinics 16, no. 2 (April 2000): 319–36. http://dx.doi.org/10.1016/s0749-0704(05)70112-3.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Govindarajan, Gurushankar, Melvin R. Hayden, Shawna A. Cooper, Said Daibes Figueroa, Lixin Ma, Timothy J. Hoffman, Craig S. Stump, and James R. Sowers. "Metabolic Derangements in the Insulin‐Resistant Heart." Journal of the CardioMetabolic Syndrome 1, no. 2 (March 2006): 102–6. http://dx.doi.org/10.1111/j.1600-0501.2008.01474.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Catto, G. R. D. "Hormonal and metabolic derangements in renal failure." Clinica Chimica Acta 164, no. 3 (May 1987): 351. http://dx.doi.org/10.1016/0009-8981(87)90310-x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Fava, Stephen, Marie-Claire Fava, and Rachel Agius. "Obesity and cardio-metabolic health." British Journal of Hospital Medicine 80, no. 8 (August 2, 2019): 466–71. http://dx.doi.org/10.12968/hmed.2019.80.8.466.

Full text

Abstract:

Obesity is a major and growing global health problem. It is associated with increased mortality as a result of an increasing number of complications, including type 2 diabetes, dyslipidaemia, hypertension, non-alcoholic hepatic steatosis, cardiovascular disease, sleep apnoea, gallbladder disease, obesity-related renal disease, increased risk of falls and injuries, and mental health problems as well as increased risk of certain malignancies. This article discusses the metabolic derangements associated with obesity. These include insulin resistance, dysglycaemia, low and dysfunctional high-density lipoprotein, formation of small dense and oxidised low-density lipoprotein, and high circulating levels of free fatty acids. This article reviews the aetiology of these derangements and their relationship to cardiovascular disease, and discusses the concept of metabolic health.

APA, Harvard, Vancouver, ISO, and other styles

15

Hsieh, Yun-Chiao, Po-Kai Yang, and Mei-Jou Chen. "Metabolic Syndrome in Polycystic Ovary Syndrome." Fertility & Reproduction 03, no. 04 (November 15, 2021): 125–35. http://dx.doi.org/10.1142/s2661318221500158.

Full text

Abstract:

Polycystic ovary syndrome (PCOS) is a common endocrinopathy in women of reproductive age. Although its essential clinical manifestation includes a plethora of symptoms and signs, which largely reflects the underlying hyperandrogenism, oligo/anovulation, and polycystic ovarian morphology, PCOS may also be associated with many metabolic derangements. These metabolic derangements happen to overlap with many of the core constituents of the metabolic syndrome (MBS)—increased insulin resistance, central obesity, and dyslipidemia. The two disorders also display similarly increased risks for certain metabolic and vascular diseases, such as type 2 diabetes mellitus, hypertension, and cardiovascular diseases. Due to the many similarities between metabolic syndrome and PCOS, this review aims to examine the evidence concerning the overlapping features, the risks for comorbidities, possible shared mechanisms, and treatment strategies in patients with coexisting PCOS and MBS.

APA, Harvard, Vancouver, ISO, and other styles

16

Roy, Suparna, and Anindya Dasgupta. "METABOLIC DERANGEMENTS AS INDICATORS OF PARTIAL HELLP SYNDROME." Journal of Evolution of Medical and Dental Sciences 6, no. 84 (October 19, 2017): 5853–56. http://dx.doi.org/10.14260/jemds/2017/1271.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Ursich, Mileni, Rosa Fukui, Dalva Rocha, Maria Silva, and B. Wajchenberg. "Metabolic Derangements in Excessive Insulin and Sulfonylurea Therapy." Hormone and Metabolic Research 25, no. 09 (September 1993): 457–61. http://dx.doi.org/10.1055/s-2007-1002148.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Sorop, Oana, Jens van de Wouw, Selena Chandler, Vahagn Ohanyan, Johnathan D. Tune, William M. Chilian, Daphne Merkus, Shawn B. Bender, and Dirk J. Duncker. "Experimental animal models of coronary microvascular dysfunction." Cardiovascular Research 116, no. 4 (January 11, 2020): 756–70. http://dx.doi.org/10.1093/cvr/cvaa002.

Full text

Abstract:

Abstract Coronary microvascular dysfunction (CMD) is commonly present in patients with metabolic derangements and is increasingly recognized as an important contributor to myocardial ischaemia, both in the presence and absence of epicardial coronary atherosclerosis. The latter condition is termed ‘ischaemia and no obstructive coronary artery disease’ (INOCA). Notwithstanding the high prevalence of INOCA, effective treatment remains elusive. Although to date there is no animal model for INOCA, animal models of CMD, one of the hallmarks of INOCA, offer excellent test models for enhancing our understanding of the pathophysiology of CMD and for investigating novel therapies. This article presents an overview of currently available experimental models of CMD—with an emphasis on metabolic derangements as risk factors—in dogs, swine, rabbits, rats, and mice. In all available animal models, metabolic derangements are most often induced by a high-fat diet (HFD) and/or diabetes mellitus via injection of alloxan or streptozotocin, but there is also a wide variety of spontaneous as well as transgenic animal models which develop metabolic derangements. Depending on the number, severity, and duration of exposure to risk factors—all these animal models show perturbations in coronary microvascular (endothelial) function and structure, similar to what has been observed in patients with INOCA and comorbid conditions. The use of these animal models will be instrumental in identifying novel therapeutic targets and for the subsequent development and testing of novel therapeutic interventions to combat ischaemic heart disease, the number one cause of death worldwide.

APA, Harvard, Vancouver, ISO, and other styles

19

Sury, Krishna. "Update on the prevention and treatment of tumor lysis syndrome." Journal of Onco-Nephrology 3, no. 1 (February 2019): 19–30. http://dx.doi.org/10.1177/2399369319837212.

Full text

Abstract:

Tumor lysis syndrome is a constellation of metabolic derangements seen when tumor cells die and release their intracellular contents into the systemic circulation. Hyperkalemia, hyperphosphatemia, hypocalcemia, and hyperuricemia may lead to severe organ dysfunction and even death. Tumor lysis syndrome is classically considered a complication of successful cancer treatment, but it can also occur in untreated malignancies characterized by rapid proliferation. In this review, we cover the types of cancers and chemo- and immunotherapies associated with tumor lysis syndrome, the mechanisms by which severe metabolic derangements can develop, and the available treatments.

APA, Harvard, Vancouver, ISO, and other styles

20

Khunger, Jitender, Monica Malhotra, Nitin Kumar, VPS Punia, and Mohan Agarwal. "To Study the Coagulation Profile Derangements in Metabolic Syndrome." Blood 134, Supplement_1 (November 13, 2019): 4959. http://dx.doi.org/10.1182/blood-2019-125048.

Full text

Abstract:

Introduction: The metabolic syndrome is a complex disorder characterized by the presence of a clustering of metabolic risk factors usually in a single individual associated with the presence of central obesity and a strong association with diabetes and cardiovascular disease morbidity and mortality. It is a fast spreading global pandemic & emerging as a public health problem with poor outcome and Quality of life thus more predilection is towards preventive than curative treatment. According to WHO Clinical Criteria, Metabolic syndrome is defined as insulin resistance, identified by 1 of the following, Type 2 diabetes, fasting blood glucose more than 110 mg/dl plus any 2 of the following: antihypertensive medication and /or high blood pressure > 140 mm systolic or >90 mm diastolic, plasma triglyceride (TG) level more than 150 mg/dl (1.7 mmol/L), high-density lipoprotein (HDL) cholesterol level less than 35 mg/dl (0.9 mmol/L) in men or less than 39 (1.0 mmol/L)in women , BMI >30 kg/m2 and/or waist:hip ratio >0.9 in men, > 0.85 in women, Urinary albumen excretion rate > 20 mcg/min or albumin:creatinine ratio>30mg/g Aims & Objectives: To investigate the coagulation profile derangements in metabolic syndrome. To study the relationship of various components of metabolic syndrome with coagulation parameters. Material & Methods: This was a prospective cross-sectional study carried out in Haematology & Medicine Deptt of SafdarJang Hospital, New Delhi. After taking consent from the Hospital Ethics Committee, a total of 50 cases of metabolic syndrome presenting as outpatient or inpatient were included in the study. 50 age & sex matched controls were selected which did not satisfy the criteria for metabolic syndrome. Observation & Results: In our study we found that the cases with metabolic syndrome have significantly increased levels of Fibrinogen, Factor VIII and Plasminogen Activator Inhibitor1 (PAI1). PT & APTT were shorter in cases with metabolic syndrome. The mean value of fibrinogen in cases was 402.24 ± 66.92 mg/dl while that in control was 261.5 ± 41.95 mg/dl with a P value of <.0001 which was statistically significant. The mean value of Factor VIII in cases was 152.66 ± 7.54 IU/dl while that in control was 131.44 ± 6.24 IU/dl with a P value of <.0001 which was statistically significant. The mean value of Plasminogen Activator Inhibitor1 (PAI1) in cases was 49.99 ± 5.34 ng/ml while that in control was 36.75 ± 3.35 ng/ml with a P value of <.0001 which was statistically significant. Prothrombin Time (PT) values in cases were 9.79 ± 0.74 seconds and in controls were 12.04 ± 0.7 seconds & this difference was statistically significant (p<.0001). Activated partial Thromboplastin Time (APTT) values in cases were 28.96 ± 0.92 seconds and in controls were 32.6 ± 1.34 seconds & this difference was statistically significant (p<.0001). Conclusions: The coagulation parameters studied correlated significantly with the components of metabolic syndrome. The values varied significantly with increased number of features of metabolic syndrome. Thus we can conclude that metabolic syndrome is a hypercoagulable state and further studies are required for further evaluation of the consequences of this hypercoagulable state.. Disclosures No relevant conflicts of interest to declare.

APA, Harvard, Vancouver, ISO, and other styles

21

Alaigh, Vivek, and Debapriya Datta. "Spontaneous Tumor Lysis Syndrome due to Uterine Leiomyosarcoma with Lung Metastases." Case Reports in Critical Care 2017 (2017): 1–4. http://dx.doi.org/10.1155/2017/4141287.

Full text

Abstract:

Tumor lysis syndrome (TLS) is an oncologic emergency characterized by a combination of metabolic derangements (hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia) caused by rapid turnover from cell destruction in certain cancers. These metabolic derangements can lead to seizures, cardiac arrhythmias, renal failure, and death. TLS is usually seen after the initiation of chemotherapy for hematologic malignancies. TLS occurring spontaneously, without initiation of chemotherapy, is rare and its occurrence in solid tumors is rarer still. We report a case of spontaneous TLS in a patient with leiomyosarcoma of the uterus, with metastasis to lung. Such a case has never been reported before.

APA, Harvard, Vancouver, ISO, and other styles

22

Volkow, Nora D., and Laurence Tancredi. "Neural Substrates of Violent Behaviour a Preliminary Study with Positron Emission Tomography." British Journal of Psychiatry 151, no. 5 (November 1987): 668–73. http://dx.doi.org/10.1192/bjp.151.5.668.

Full text

Abstract:

Brain function was evaluated in four psychiatric patients with a history of repetitive purposeless violent behaviour, using EEG, CT scan, and positron emission tomography (PET). Three patients showed spiking activity in left temporal regions, and two showed CT scan abnormalities characterised by generalised cortical atrophy. The PET scans for the four cases showed evidence of blood flow and metabolic abnormalities in the left temporal lobe. Two patients also had derangement in the frontal cortex. The patients showing the largest defects with the PET scans were those whose CT scans were reported as normal. This paper shows the utility of PET in investigating possible brain derangements that could lead to violent behaviour.

APA, Harvard, Vancouver, ISO, and other styles

23

KENING, MATTHEW, JESSICA SCHUMANN, FREDERICK GMORA, KATELYN A HANSON, and OLUBUNMI OLAREWAJU. "HYPERGLYCEMIA WITH METABOLIC DERANGEMENTS: ALTERNATIVE ETIOLOGIES BEYOND DIABETIC KETOACIDOSIS." Chest 162, no. 4 (October 2022): A684. http://dx.doi.org/10.1016/j.chest.2022.08.537.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Maneschi, Elena, Annamaria Morelli, Sandra Filippi, Ilaria Cellai, Paolo Comeglio, Benedetta Mazzanti, Tommaso Mello, et al. "Testosterone treatment improves metabolic syndrome-induced adipose tissue derangements." Journal of Endocrinology 215, no. 3 (October 8, 2012): 347–62. http://dx.doi.org/10.1530/joe-12-0333.

Full text

Abstract:

We recently demonstrated that testosterone dosing ameliorated the metabolic profile and reduced visceral adipose tissue (VAT) in a high-fat diet (HFD)-induced rabbit model of metabolic syndrome (MetS). We studied the effects of HFD and in vivo testosterone dosing on VAT function and the adipogenic capacity of rabbit preadipocytes isolated from VAT of regular diet (RD), HFD, and testosterone-treated HFD rabbits. VAT was studied by immunohistochemistry, western blot, and RT-PCR. Isolated rPADs were exposed to adipocyte differentiating mixture (DIM) to evaluate adipogenic potential. Adipocyte size was significantly increased in HFD VAT compared with RD, indicating adipocyte dysfunction, which was normalized by testosterone dosing. Accordingly, perilipin, an anti-lipolytic protein, was significantly increased in HFD VAT, when compared with other groups. HFD VAT was hypoxic, while testosterone dosing normalized VAT oxygenation. In VAT, androgen receptor expression was positively associated with mRNA expression of GLUT4 (SLC2A4) (insulin-regulated glucose transporter) and STAMP2 (STEAP4) (androgen-dependent gene required for insulin signaling). In testosterone-treated HFD VAT, STAMP2 mRNA was significantly increased when compared with the other groups. Moreover, GLUT4 membrane translocation was significantly reduced in HFD VAT, compared with RD, and increased by testosterone. In DIM-exposed preadipocytes from HFD, triglyceride accumulation, adipocyte-specific genes, insulin-stimulated triglyceride synthesis, glucose uptake, and GLUT4 membrane translocation were reduced compared with preadipocytes from RD and normalized by in vivo testosterone dosing. In conclusion, testosterone dosing in a MetS animal model positively affects VAT functions. This could reflect the ability of testosterone in restoring insulin sensitivity in VAT, thus counteracting metabolic alterations.

APA, Harvard, Vancouver, ISO, and other styles

25

Koh, Shin O., and Yong T. Nam. "METABOLIC AND HEMODYNAMIC DERANGEMENTS OF BRAIN-DEAD ORGAN DONORS." Critical Care Medicine 27, Supplement (December 1999): A148. http://dx.doi.org/10.1097/00003246-199912001-00422.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

Lee, Ni-Chung, Yin-Hsiu Chien, Shinn-Forng Peng, Ai-Chu Huang, Tze-Tze Liu, Ariel Sing-Huei Wu, Li-Chu Chen, Li-Wen Hsu, Shih-Chuan Tseng, and Wuh-Liang Hwu. "Brain Damage by Mild Metabolic Derangements in Methylmalonic Acidemia." Pediatric Neurology 39, no. 5 (November 2008): 325–29. http://dx.doi.org/10.1016/j.pediatrneurol.2008.07.018.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

Misra, Anoop, and Abhimanyu Garg. "Clinical Features and Metabolic Derangements in Acquired Generalized Lipodystrophy." Medicine 82, no. 2 (March 2003): 129–46. http://dx.doi.org/10.1097/00005792-200303000-00007.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Tevy, Maria Florencia, Jadwiga Giebultowicz, Zachary Pincus, Gianluigi Mazzoccoli, and Manlio Vinciguerra. "Aging signaling pathways and circadian clock-dependent metabolic derangements." Trends in Endocrinology & Metabolism 24, no. 5 (May 2013): 229–37. http://dx.doi.org/10.1016/j.tem.2012.12.002.

Full text

APA, Harvard, Vancouver, ISO, and other styles

29

van Niekerk, Gustav, and Anna-Mart Engelbrecht. "Inflammation-induced metabolic derangements or adaptation: An immunometabolic perspective." Cytokine & Growth Factor Reviews 43 (October 2018): 47–53. http://dx.doi.org/10.1016/j.cytogfr.2018.06.003.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Tran, LanChi, Umeshkumar Athiraman, Keith M. Rich, and Rene Tempelhoff. "Hyperventilation, Sympathetic and Metabolic Derangements After Endoscopic Third Ventriculostomy." Journal of Neurosurgical Anesthesiology 29, no. 1 (January 2017): 61–62. http://dx.doi.org/10.1097/ana.0000000000000250.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

Pham, Amy Quynh Trang, Li Hao Richie Xu, and Orson W. Moe. "Drug-Induced Metabolic Acidosis." F1000Research 4 (December 16, 2015): 1460. http://dx.doi.org/10.12688/f1000research.7006.1.

Full text

Abstract:

Metabolic acidosis could emerge from diseases disrupting acid-base equilibrium or from drugs that induce similar derangements. Occurrences are usually accompanied by comorbid conditions of drug-induced metabolic acidosis, and clinical outcomes may range from mild to fatal. It is imperative that clinicians not only are fully aware of the list of drugs that may lead to metabolic acidosis but also understand the underlying pathogenic mechanisms. In this review, we categorized drug-induced metabolic acidosis in terms of pathophysiological mechanisms, as well as individual drugs’ characteristics.

APA, Harvard, Vancouver, ISO, and other styles

32

Wei, Zhikui, You Chen, and Raghu P. Upender. "Sleep Disturbance and Metabolic Dysfunction: The Roles of Adipokines." International Journal of Molecular Sciences 23, no. 3 (February 1, 2022): 1706. http://dx.doi.org/10.3390/ijms23031706.

Full text

Abstract:

Adipokines are a growing group of peptide or protein hormones that play important roles in whole body metabolism and metabolic diseases. Sleep is an integral component of energy metabolism, and sleep disturbance has been implicated in a wide range of metabolic disorders. Accumulating evidence suggests that adipokines may play a role in mediating the close association between sleep disorders and systemic metabolic derangements. In this review, we briefly summarize a group of selected adipokines and their identified function in metabolism. Moreover, we provide a balanced overview of these adipokines and their roles in sleep physiology and sleep disorders from recent human and animal studies. These studies collectively demonstrate that the functions of adipokine in sleep physiology and disorders could be largely twofold: (1) adipokines have multifaceted roles in sleep physiology and sleep disorders, and (2) sleep disturbance can in turn affect adipokine functions that likely contribute to systemic metabolic derangements.

APA, Harvard, Vancouver, ISO, and other styles

33

Ohmi, H., K. Ichihara, and Y. Abiko. "Role of oxygen radicals in canine myocardial metabolic derangement during regional ischemia." American Journal of Physiology-Heart and Circulatory Physiology 262, no. 2 (February 1, 1992): H553—H561. http://dx.doi.org/10.1152/ajpheart.1992.262.2.h553.

Full text

Abstract:

To clarify the role of oxygen radicals in the development of myocardial injury during ischemia, production of lipid peroxides mediated by oxygen radicals was determined in in vivo dogs subjected to regional ischemia and reperfusion. Myocardial injury was assessed by derangement in energy and carbohydrate metabolism caused by ischemia and reperfusion. The production of lipid peroxides mediated by oxygen radicals considerably increased not only during reperfusion after ischemia but also during ischemia. Removal of oxygen radicals by administration of radical scavengers [recombinant human superoxide dismutase + catalase or N-(2-mercaptopropionyl)glycine] completely prevented the increase in production of lipid peroxides during ischemia. However, the radical scavengers did not attenuate the myocardial energy and carbohydrate metabolic derangements caused by ischemia and reperfusion after ischemia. These results suggest that significant amounts of oxygen radicals are generated during ischemia as well as during reperfusion and that the oxygen radicals and subsequent lipid peroxidation are not major factors in development of myocardial injury during either ischemia or reperfusion after ischemia.

APA, Harvard, Vancouver, ISO, and other styles

34

Little, JA, NJ Dempsey, M. Tuchman, and GD Ginder. "Metabolic persistence of fetal hemoglobin." Blood 85, no. 7 (April 1, 1995): 1712–18. http://dx.doi.org/10.1182/blood.v85.7.1712.bloodjournal8571712.

Full text

Abstract:

Hereditary persistence of fetal hemoglobin (HPFH) has typically been ascribed to mutations in the beta-globin gene cluster. Pharmacologic agents, including the short-chain fatty acid butyrate, have been shown to upregulate fetal and embryonic globin gene expression. In this report we investigate the possibility that metabolic derangements characterized by an inability to metabolize another short-chain fatty acid, propionate, could be associated with a persistence of fetal hemoglobin unrelated to alterations in the beta-globin cluster. Embryonic globin gene upregulation in a murine adult erythroid cell culture was shown by RNase protection after induction with three short-chain fatty acids (C2-C5). Chart reviews and measurement of fetal hemoglobin in five patients with abnormalities in propionate (C3) metabolism were undertaken; SSCP/dideoxy fingerprint analysis of the gamma-globin gene promoters was done in three of these five patients. Twelve patients with other metabolic derangements served as controls. Only the four patients with clinically severe abnormalities in propionate metabolism (ages 2 to 11), but without anemia, showed a sustained elevation in fetal hemoglobin (3% to 10%). The level of elevation of fetal hemoglobin in these patients, who lack erythropoietic stress, suggests that propionic acid and/or its metabolites are potent stimulators of fetal hemoglobin expression. Study of this group of patients should allow unique insights into the long-term effects of sustained exposure to elevations of short-chain fatty acid levels.

APA, Harvard, Vancouver, ISO, and other styles

35

Kissoon, N., T. C. Frewen, M. Bloch, M. Gayle, and C. Stiller. "Pediatric Organ Donor Maintenance: Pathophysiologic Derangements and Nursing Requirements." Pediatrics 84, no. 4 (October 1, 1989): 688–93. http://dx.doi.org/10.1542/peds.84.4.688.

Full text

Abstract:

A retrospective chart review was conducted of 26 organ donors to determine hemodynamic and metabolic derangements encountered and nursing requirements for donor organ maintenance. There were 15 boys and 11 girls with a mean age 6.57 ± 5.46 years. Mean donor maintenance time was 10.5 ± 6.7 hours. Cardiorespiratory derangements included hypotension in 16, hypertension in 6, arrhythmias in 17 (premature ventricular contraction in 4, bradycardia in 8, paroxysmal atrial tachycardia in 3, and ventricular tachycardia in 2), asystolic events in 5, pulmonary insufficiency in 6, anemia in 8, and thrombocytopenia in 8. Metabolic and hormonal derangements included hyperglycemia in 18, hypokalemia in 20, hyperkalemia in 4, hyponatremia in 3, hypernatremia in 17, metabolic acidosis in 10, and diabetes insipidus in 15. Hypothermia (temperature 33.3°± 0.4°C, mean ± SD) occurred in 14 donors. The mean physiologic Stability Index score was 22.2 ± 4.7 and mean Therapeutic Intervention Score was 46.7 ± 5.8. Total number of nursing hours spent in donor maintenance was 424.5 hours. Therapies offered included diuretics in 10, sodium bicarbonate in 8, antibiotics in 6, insulin in 12, pitressin in 13, verapamil in 3, isoproterenol in 3, dopamine in 17, and intravenous potassium boluses in 14. Of the potential 26 donors, 46 kidneys, 8 hearts, 14 livers, 3 pancreas, and 9 corneas were retrieved in transplantable condition. With appropriate donor maintenance, organs suitable for transplantation can be retrieved despite significant pathophysiologic derangements. Physicians intending to provide donor support should be comfortable with invasive monitoring and cardiorespiratory support and be prepared to provide a nurse to patient ratio of 2:1 at the bedside.

APA, Harvard, Vancouver, ISO, and other styles

36

Lind, Lars, Samira Salihovic, Johan Sundström, Sölve Elmståhl, Ulf Hammar, Koen Dekkers, Johan Ärnlöv, J. Gustav Smith, Gunnar Engström, and Tove Fall. "Metabolic Profiling of Obesity With and Without the Metabolic Syndrome: A Multisample Evaluation." Journal of Clinical Endocrinology & Metabolism 107, no. 5 (January 4, 2022): 1337–45. http://dx.doi.org/10.1210/clinem/dgab922.

Full text

Abstract:

Abstract Context There is a dispute whether obesity without major metabolic derangements may represent a benign condition or not. Objective We aimed to compare the plasma metabolome in obese subjects without metabolic syndrome (MetS) with normal-weight subjects without MetS and with obese subjects with MetS. Methods This was a cross-sectional study at 2 academic centers in Sweden. Individuals from 3 population-based samples (EpiHealth, n = 2342, SCAPIS-Uppsala, n = 4985, and SCAPIS-Malmö, n = 3978) were divided into groups according to their body mass index (BMI) and presence/absence of MetS (National Cholesterol Education Program [NCEP]/consensus criteria). In total, 791 annotated endogenous metabolites were measured by ultra-performance liquid chromatography–tandem mass spectrometry. Results We observed major differences in metabolite profiles (427 metabolites) between obese (BMI ≥ 30 kg/m2) and normal-weight (BMI < 25 kg/m2) subjects without MetS after adjustment for major lifestyle factors. Pathway enrichment analysis highlighted branch-chained and aromatic amino acid synthesis/metabolism, aminoacyl-tRNA biosynthesis, and sphingolipid metabolism. The same pathways, and similar metabolites, were also highlighted when obese subjects with and without MetS were compared despite adjustment for BMI and waist circumference, or when the metabolites were related to BMI and number of MetS components in a continuous fashion. Similar metabolites and pathways were also related to insulin sensitivity (Matsuda index) in a separate study (POEM, n = 501). Conclusion Our data suggest a graded derangement of the circulating metabolite profile from lean to obese to MetS, in particular for metabolites involved in amino acid synthesis/metabolism and sphingolipid metabolism. Insulin resistance is a plausible mediator of this gradual metabolic deterioration.

APA, Harvard, Vancouver, ISO, and other styles

37

Yan, Xiaonan, Xiaonan Dai, Jing Wang, Nannan Zhao, Yugui Cui, and Jiayin Liu. "Prenatal androgen excess programs metabolic derangements in pubertal female rats." Journal of Endocrinology 217, no. 1 (February 20, 2013): 119–29. http://dx.doi.org/10.1530/joe-12-0577.

Full text

Abstract:

Owing to the heterogeneity in the clinical symptoms of polycystic ovary syndrome (PCOS), the early pathophysiological mechanisms of PCOS remain unclear. Clinical, experimental, and genetic evidence supports an interaction between genetic susceptibility and the influence of maternal environment in the pathogenesis of PCOS. To determine whether prenatal androgen exposure induced PCOS-related metabolic derangements during pubertal development, we administrated 5α-dihydrotestosterone (DHT) in pregnant rats and observed their female offspring from postnatal 4 to 8 weeks. The prenatally androgenized (PNA) rats exhibited more numerous total follicles, cystic follicles, and atretic follicles than the controls. Fasting glucose, insulin, leptin levels, and homeostatic model assessment for insulin resistance were elevated in the PNA rats at the age of 5–8 weeks. Following intraperitoneal glucose tolerance tests, glucose and insulin levels did not differ between two groups; however, the PNA rats showed significantly higher 30- and 60-min glucose levels than the controls after insulin stimulation during 5–8 weeks. In addition, prenatal DHT treatment significantly decreased insulin-stimulated phosphorylation of AKT in the skeletal muscles of 6-week-old PNA rats. The abundance of IR substrate 1 (IRS1) and IRS2 was decreased in the skeletal muscles and liver after stimulation with insulin in the PNA group, whereas phosphorylation of insulin-signaling proteins was unaltered in the adipose tissue. These findings validate the contribution of prenatal androgen excess to metabolic derangements in pubertal female rats, and the impaired insulin signaling through IRS and AKT may result in the peripheral insulin resistance during pubertal development.

APA, Harvard, Vancouver, ISO, and other styles

38

Gilliland, Taylor, Nicole Villafane-Ferriol, Kevin Shah, Rohan Shah, Hop Tran Cao, Nader Massarweh, Eric Silberfein, et al. "Nutritional and Metabolic Derangements in Pancreatic Cancer and Pancreatic Resection." Nutrients 9, no. 3 (March 7, 2017): 243. http://dx.doi.org/10.3390/nu9030243.

Full text

APA, Harvard, Vancouver, ISO, and other styles

39

Ehrlich, Garth D. "LncRNAs H19 and MEG3 as Universal Indicators of Metabolic Derangements?" Genetic Testing and Molecular Biomarkers 24, no. 6 (June 1, 2020): 319–20. http://dx.doi.org/10.1089/gtmb.2020.0117.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Heinonen, S., L. Saarinen, J. Naukkarinen, A. Rodríguez, G. Frühbeck, A. Hakkarainen, J. Lundbom, et al. "Adipocyte morphology and implications for metabolic derangements in acquired obesity." International Journal of Obesity 38, no. 11 (February 19, 2014): 1423–31. http://dx.doi.org/10.1038/ijo.2014.31.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Ali, A., A. Deeb, A. Orabi, M. Abdu, and A. Gad. "Pattern of Thyroid Functional Derangements in Patients with Metabolic Syndrome." British Journal of Medicine and Medical Research 20, no. 9 (January 10, 2017): 1–10. http://dx.doi.org/10.9734/bjmmr/2017/32311.

Full text

APA, Harvard, Vancouver, ISO, and other styles

42

Swithers, Susan E. "Artificial sweeteners produce the counterintuitive effect of inducing metabolic derangements." Trends in Endocrinology & Metabolism 24, no. 9 (September 2013): 431–41. http://dx.doi.org/10.1016/j.tem.2013.05.005.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Baldin, Alexandre Duarte, Adriana Aparecida Siviero-Miachon, Tatiana Fabbri, Sofia Helena Valente de Lemos-Marini, Angela Maria Spinola-Castro, Maria Tereza Matias Baptista, Lilia Freire Rodrigues D'Souza-Li, André Moreno Morcillo, Andrea Trevas Maciel-Guerra, and Gil Guerra-Junior. "Turner syndrome and metabolic derangements: Another example of fetal programming." Early Human Development 88, no. 2 (February 2012): 99–102. http://dx.doi.org/10.1016/j.earlhumdev.2011.07.014.

Full text

APA, Harvard, Vancouver, ISO, and other styles

44

Rudloff, Elke. "Diabetic ketoacidosis in the cat: Recognition and essential treatment." Journal of Feline Medicine and Surgery 19, no. 11 (October 25, 2017): 1167–74. http://dx.doi.org/10.1177/1098612x17735762.

Full text

Abstract:

Practical relevance: Diabetic ketoacidosis (DKA) is a not uncommon emergency in both newly diagnosed and poorly regulated diabetic cats. When there is a heightened metabolic rate and energy requirement due to concurrent illness, an increase in the release of glucose counter-regulatory hormones causes insulin receptor resistance, lipolysis, free fatty acid release and ketogenesis. This necessitates not only treatment to eliminate the ketosis and control blood glucose, but also investigation of concurrent illnesses. Clinical challenges: A number of metabolic derangements can occur with DKA, requiring a comprehensive diagnostic evaluation, elimination of ketones, careful correction of glucose, electrolyte and acid base abnormalities, and close monitoring. Audience: Any veterinarian that cares for cats in urgent and emergency situations should understand the pathophysiology of DKA in order to address an individual’s clinical signs and metabolic derangements. Evidence base: This review draws evidence from the peer-reviewed literature as well as the author’s personal clinical experience.

APA, Harvard, Vancouver, ISO, and other styles

45

van den Bunder, Fenne A. I. M., Nigel J. Hall, L. W. Ernest van Heurn, and Joep P. M. Derikx. "A Delphi Analysis to Reach Consensus on Preoperative Care in Infants with Hypertrophic Pyloric Stenosis." European Journal of Pediatric Surgery 30, no. 06 (January 20, 2020): 497–504. http://dx.doi.org/10.1055/s-0039-3401987.

Full text

Abstract:

Abstract Introduction Infantile hypertrophic pyloric stenosis (IHPS) is a common gastrointestinal condition that can lead to metabolic alkalosis and, if uncorrected, to respiratory complications. A standardized approach to correct metabolic derangements and dehydration may reduce time until pyloromyotomy while preventing potential respiratory complications. Such an evidence-based policy regarding preoperative care is absent. We aim to formulate a recommendation about preoperative care for infants with IHPS using the Delphi technique. Materials and Methods The RAND/UCLA appropriateness method was used to reach international consensus in a panel of pediatric surgeons, pediatric anesthetists, and pediatricians. Statements on type and frequency of blood sampling, required serum concentrations before pyloromyotomy and intravenous fluid therapy, were rated online using a 9-point Likert scale. Consensus was present if the panel rated the statement appropriate/obligatory (panel median: 7–9) or inappropriate/unnecessary (panel median: 1–3) without disagreement according to the interpercentile range adjusted for symmetry formula. Results Thirty-three and twenty-nine panel members completed the first and second round, respectively. Consensus was reached in 54/74 statements (73%). The panel recommended the following laboratory tests and corresponding cutoff values prior to pyloromyotomy: pH ≤7.45, base excess ≤3.5, bicarbonate <26 mmol/L, sodium ≥132 mmol/L, potassium ≥3.5 mmol/L, chloride ≥100 mmol/L, and glucose ≥4.0 mmol/L. Isotonic crystalloid with 5% dextrose and 10 to 20 mEq/L potassium should be used for fluid resuscitation. Conclusion Consensus is reached in an expert panel about assessment of metabolic derangements at admission, cutoff serum concentrations to be achieved prior to pyloromyotomy, and appropriate intravenous fluid regime for the correction of dehydration and metabolic derangements in infants with IHPS.

APA, Harvard, Vancouver, ISO, and other styles

46

Parisi, Francesca, Roberta Milazzo, Valeria M. Savasi, and Irene Cetin. "Maternal Low-Grade Chronic Inflammation and Intrauterine Programming of Health and Disease." International Journal of Molecular Sciences 22, no. 4 (February 9, 2021): 1732. http://dx.doi.org/10.3390/ijms22041732.

Full text

Abstract:

Overweight and obesity during pregnancy have been associated with increased birth weight, childhood obesity, and noncommunicable diseases in the offspring, leading to a vicious transgenerational perpetuating of metabolic derangements. Key components in intrauterine developmental programming still remain to be identified. Obesity involves chronic low-grade systemic inflammation that, in addition to physiological adaptations to pregnancy, may potentially expand to the placental interface and lead to intrauterine derangements with a threshold effect. Animal models, where maternal inflammation is mimicked by single injections with lipopolysaccharide (LPS) resembling the obesity-induced immune profile, showed increased adiposity and impaired metabolic homeostasis in the offspring, similar to the phenotype observed after exposure to maternal obesity. Cytokine levels might be specifically important for the metabolic imprinting, as cytokines are transferable from maternal to fetal circulation and have the capability to modulate placental nutrient transfer. Maternal inflammation may induce metabolic reprogramming at several levels, starting from the periconceptional period with effects on the oocyte going through early stages of embryonic and placental development. Given the potential to reduce inflammation through inexpensive, widely available therapies, examinations of the impact of chronic inflammation on reproductive and pregnancy outcomes, as well as preventive interventions, are now needed.

APA, Harvard, Vancouver, ISO, and other styles

47

&NA;. "Pioglitazone raises HDL-cholesterol and improves several metabolic derangements in nondiabetic patients with metabolic syndrome,." Inpharma Weekly &NA;, no. 1525 (February 2006): 19. http://dx.doi.org/10.2165/00128413-200615250-00049.

Full text

APA, Harvard, Vancouver, ISO, and other styles

48

Barili, Valeria, Andrea Vecchi, Marzia Rossi, Ilaria Montali, Camilla Tiezzi, Amalia Penna, Diletta Laccabue, Gabriele Missale, Paola Fisicaro, and Carolina Boni. "Unraveling the Multifaceted Nature of CD8 T Cell Exhaustion Provides the Molecular Basis for Therapeutic T Cell Reconstitution in Chronic Hepatitis B and C." Cells 10, no. 10 (September 28, 2021): 2563. http://dx.doi.org/10.3390/cells10102563.

Full text

Abstract:

In chronic hepatitis B and C virus infections persistently elevated antigen levels drive CD8+ T cells toward a peculiar differentiation state known as T cell exhaustion, which poses crucial constraints to antiviral immunity. Available evidence indicates that T cell exhaustion is associated with a series of metabolic and signaling deregulations and with a very peculiar epigenetic status which all together lead to reduced effector functions. A clear mechanistic network explaining how intracellular metabolic derangements, transcriptional and signaling alterations so far described are interconnected in a comprehensive and unified view of the T cell exhaustion differentiation profile is still lacking. Addressing this issue is of key importance for the development of innovative strategies to boost host immunity in order to achieve viral clearance. This review will discuss the current knowledge in HBV and HCV infections, addressing how innate immunity, metabolic derangements, extensive stress responses and altered epigenetic programs may be targeted to restore functionality and responsiveness of virus-specific CD8 T cells in the context of chronic virus infections.

APA, Harvard, Vancouver, ISO, and other styles

49

Osman, Y., H. Mangray, and N. Allorto. "A case of bowel perforation secondary to burn conversion." South African Journal of Surgery 60, no. 4 (December 2022): 305–6. http://dx.doi.org/10.17159/2078-5151/sajs3838.

Full text

Abstract:

Burn conversion is a process by which superficial partial-thickness burns spontaneously progress into deep partial-thickness or full-thickness wounds. Factors that influence this process centre around poor perfusion which can be related to either too much or too little fluid resuscitation, infection, free radical damage, and metabolic or nutritional derangements. Therein lies the role of preventative strategies, i.e., adequate fluid resuscitation, prompt identification and management of sepsis, correction of electrolyte derangements and early institution of feeds. Prevention of burn conversion could prevent the need for surgical intervention and improve the morbidity and mortality of burns patients.

APA, Harvard, Vancouver, ISO, and other styles

50

Molfino, Alessio, Giovanni Imbimbo, and Maurizio Muscaritoli. "The relevance of nutritional and metabolic derangements in COVID-19 patients." European Journal of Internal Medicine 96 (February 2022): 120. http://dx.doi.org/10.1016/j.ejim.2021.12.017.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!