Dissertations / Theses on the topic 'Metabolic Aspects'
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Svensson, Maria. "Metabolic aspects on diabetic nephropathy." Doctoral thesis, Umeå University, Public Health and Clinical Medicine, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-79.
Full textDiabetic nephropathy (DN) is associated with morbidity and mortality due to cardiovascular disease and renal failure. This study focused on the impact of glycemic control on the development of DN and the metabolic consequences of DN. The euglycemic hyperinsulinemic clamp technique was used to assess insulin sensitivity and insulin clearance. Two different registries, the Diabetes Incidence Study in Sweden (DISS) and the Swedish Childhood Diabetes Registry, as well as questionnaires and data from medical records were used to study diabetic complications in population-based cohorts.
Microalbuminuria is an early marker of DN and may also be associated with impaired insulin sensitiv-ity in diabetic and non-diabetic subjects. We studied the relationship between insulin sensitivity and the degree of albuminuria in patients with type 1 diabetes and micro- or macroalbuminuria but normal glomerular filtration rate (GFR). We did not find a direct quantitative association between the degree of albuminuria and insulin resistance, arguing against a cause-effect relationship.
With progression of DN, a decline in GFR is seen. Patients with severe renal failure have both im-paired insulin sensitivity and insulin clearance. We studied insulin sensitivity and insulin clearance in type 1 diabetes patients with three different degrees of renal involvement (none, only albuminuria, and slightly reduced GFR, ~40-70 ml/min/1.73 m2, respectively). A clear reduction in insulin sensitivity in vivo, but not in insulin clearance, was seen in the group with reduced GFR, and concomitant changes in the levels of PTH, IGF-1, IL-6 and TNF-α were found. In parallel, cellular insulin sensitivity and insulin degradation were examined in vitro, in subcutaneous fat cells but no differences were found between the three groups of patients.
To study the occurrence of renal involvement in patients with modern diabetes treatment we moni-tored a cohort of young adults from the DISS-registry with onset of diabetes in 1987-88 at age 15-34 years. We found that ~7% of the patients had signs of renal involvement, i.e. incipient nephropathy (5%) and overt nephropathy (2%), after a median follow-up of ~9 years and the strongest risk markers were poor glycemic control (HbA1c) and high blood pressure. Patients with type 2 diabetes were most prone to have renal involvement in this age group.
Retrospectively, we studied 94 patients diagnosed with type 1 diabetes in 1981-1992 at age 0-14 years at the Umeå University Hospital. Incipient nephropathy and background retinopathy occurred in 18 and 45%, respectively, of the patients, during ~12 years of follow-up. Glycemic control, also during the first five years of diabetes, was a strong risk marker. Young age at onset of diabetes prolonged the time to development of microvascular complications.
Conclusion: Despite modern diabetes treatment some patients with diabetes develop renal involvement within the first ten years. Inadequate glycemic control, also early in the disease, is a risk marker as well as type 2 diabetes and high blood pressure. In patients with type 1 diabetes and diabetic neph-ropathy a slightly reduced GFR, but not albuminuria, is associated with insulin resistance. Concomi-tant changes in insulin-antagonistic hormones and cytokines may be involved.
Small, J. R. "Theoretical aspects of metabolic control." Thesis, Oxford Brookes University, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.382208.
Full textGauna, Carlotta. "Metabolic aspects of the ghrelin system." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2007. http://hdl.handle.net/1765/10528.
Full textYasmin, Ephia. "Metabolic aspects of polycystic ovary syndrome." Thesis, University of Leeds, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.545722.
Full textRiley, Marshall S. "Metabolic aspects of chronic cardiac failure." Thesis, Queen's University Belfast, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335264.
Full textWardle, Catherine A. "Metabolic aspects of the hypoxic heart." Thesis, University of Edinburgh, 1990. http://hdl.handle.net/1842/20278.
Full textLindholm, Åsa Maria. "Metabolic Aspects in the Polycystic Ovary Syndrome." Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-120235.
Full textLindholm, Åsa Maria. "Metabolic Aspects in the Polycystic Ovary Syndrome." Doctoral thesis, Uppsala universitet, Institutionen för kvinnors och barns hälsa, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-120235.
Full textBisi, Maria Cristina <1983>. "Bioengineering of exercise: biomechanical and metabolic aspects." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2010. http://amsdottorato.unibo.it/2543/.
Full textL’ambito di ricerca di questa tesi riguarda la bioingegneria dell’esercizio fisico, in particolare l’integrazione tra conoscenze biomeccaniche e metaboliche. La relazione tra questi due aspetti consentirebbe una valutazione completa dell’esercizio fisico che potrebbe aiutare la pratica clinica in diversi ambiti (ottimizzazione della performance di atleti, comprensione e compensazione del consumo energetico nei pazienti protesizzati, identificazione di esercizi ad alto consumo calorico e basso carico alle articolazioni per pazienti in sovrappeso). Inoltre, potrebbe avere applicazioni tecniche nel design di macchine per il fitness e per la riabilitazione. Lo scopo di questo lavoro era di approfondire la conoscenza riguardante la relazione tra lavoro meccanico e costo energetico metabolico durante il movimento, attraverso l’utilizzo di modelli interpretativi. Il problema è stato affrontato attraverso l’utilizzo di modelli muscolo scheletrici che includono oltre alla descrizione meccanica anche la descrizione della spesa energetica muscolare e che quindi permettono di valutare il movimento umano sia in termini meccanici che in termini di spesa energetica. E’ stato identificato in letteratura un modello muscolo scheletrico dell’intero corpo che potesse descrivere sia aspetti meccanici che metabolici; tale modello è stato applicato e validato utilizzando un approccio guidato da dati sperimentali di cinematica e elettromiografia (EMG-driven). Il vantaggio principale nell’utilizzo di un approccio EMG-driven è evitare l’introduzione di funzioni di ottimizzazione arbitrarie che servono per risolvere il problema indeterminato delle forze muscolari attorno alle articolazioni. E’ stata quindi condotta un’analisi di sensitività sul modello con lo scopo di conoscere quanto le variazioni nei parametri possono influire sulle uscite del modello stesso: i risultati hanno mostrato che variazioni dei parametri all’interno di range fisiologici non influenzano largamente le uscite del modello. Successivamente, il modello muscolo scheletrico è stato applicato ai dati sperimentali al fine di valutare la sua capacità predittiva: la valutazione è stata prima effettuata su un esercizio semplice (leg press unilaterale) e poi su uno più completo (esercizio ellittico). Le predizioni energetiche del modello sono risultate vicine ai dati di consumo energetici stimati tramite calorimetria indiretta nei casi studiati, in particolare alle basse velocità di esercizio e a diversi livelli di intensità. In conclusione, l’utilizzo di modelli muscolo scheletrici per predire il consumo energetico è risultato promettente e l’uso di un approccio EMG-driven ha permesso di evitare l’utilizzo di funzioni di ottimizzazione. Sebbene i risultati ottenuti siano preliminari e molti aspetti dell’approccio proposto debbano essere ulteriormente studiati, le conclusioni di questa tesi suggeriscono che la modellazione muscolo scheletrica può essere uno strumento utile per rispondere a domande riguardanti l’efficienza del movimento in soggetti sani o patologici.
Guberović, Iva. "The metabolic aspects of macroH2A histone variants." Doctoral thesis, Universitat de Barcelona, 2021. http://hdl.handle.net/10803/673875.
Full textShirazi, Farshad 1963. "Metabolic aspects of neonatal rat cardiomyocyte hypertrophy." Diss., The University of Arizona, 1997. http://hdl.handle.net/10150/282447.
Full textJenkins, Timothy Mark. "Molecular and metabolic aspects of succinate thiokinase." Thesis, University of Bath, 1988. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383299.
Full textGhosh, Nandini. "MOLECULAR ASPECTS OF LIPID METABOLISM IN NUTRITIONAL INTERVENTIONS: FOCUS ON DEGENERATIVE METABOLIC CONDITIONS." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu156346872132189.
Full textDuijnhoven, Elly M. van. "Metabolic and pharmacokinetic aspects of tacrolimus in renal transplantation." Maastricht : Maastricht : Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 2002. http://arno.unimaas.nl/show.cgi?fid=7135.
Full textCervellati, Claudia <1983>. "Metabolic and molecular aspects of cyanogenesis in apricot seed." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2011. http://amsdottorato.unibo.it/3843/.
Full textBosagh, Zadeh Ali Reza. "Some aspects of the metabolic response to surgical trauma." Thesis, King's College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299907.
Full textAudet, Diane. "Metabolic cost of aerobic dance circuit training." Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=56816.
Full textTan, Bee Kang. "Adipokines and the Metabolic Aspects of the Polycystic Ovary Syndrome." Thesis, University of Warwick, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.490677.
Full textGemert, Wilhelmus Gerardus van. "Surgical treatment of morbid obesity technical, psychosocial and metabolic aspects /." [Maastricht : Maastricht : Universiteit Maastricht] ; University Library, Maastricht University [Host], 1999. http://arno.unimaas.nl/show.cgi?fid=8566.
Full textTaveroff, Arlene. "Metabolic derangements following bone marrow transplantation : an integrated analysis." Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=74259.
Full textHesselink, Matthijs Karel Christiaan. "Structural, functional and metabolic aspects of shortening and lengthening muscle contractions." Maastricht : Maastricht : Universiteit Maastricht ; University Library, Maastricht University [Host], 1998. http://arno.unimaas.nl/show.cgi?fid=6030.
Full textBöttiger, Ylva. "Metabolic drug interactions in man : methodological aspects on in vivo studies /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4207-2/.
Full textBruce, N. C. "Enzymic and metabolic aspects of aromatic ring degradation in nocardioform actinomycetes." Thesis, University of Kent, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376346.
Full textBishop, Stephen Christopher. "Genetic and metabolic aspects of growth and its components in mice." Thesis, University of Edinburgh, 1985. http://hdl.handle.net/1842/10817.
Full textAinslie, Philip N. "The prolonged exercise of hill walking : physiological, metabolic and ergonomic aspects." Thesis, Liverpool John Moores University, 2002. http://researchonline.ljmu.ac.uk/4995/.
Full textWesthoff, Philipp [Verfasser]. "Metabolic aspects of host pathogen interactions revealed by metabolomics / Philipp Westhoff." Greifswald : Universitätsbibliothek Greifswald, 2016. http://d-nb.info/1112473602/34.
Full textKhoo, Kong Kheong. "The influence of metabolic phenotypes upon the development of colorectal neoplasia /." Title page, table of contents and conclusions only, 1995. http://web4.library.adelaide.edu.au/theses/09MD/09mdk45.pdf.
Full textFlynn, Michael Gerald. "Fat storage in athletes : the metabolic and hormonal responses to swimming and running exercise." Virtual Press, 1987. http://liblink.bsu.edu/uhtbin/catkey/516210.
Full textFerguson, Matthew J. "The metabolic and muscular adaptations to cycle training with Powercranks." Virtual Press, 2007. http://liblink.bsu.edu/uhtbin/catkey/1371690.
Full textSchool of Physical Education, Sport, and Exercise Science
Rautio, K. (Katriina). "Effects of insulin-lowering drugs in PCOS: endocrine, metabolic and inflammatory aspects." Doctoral thesis, University of Oulu, 2006. http://urn.fi/urn:isbn:951428268X.
Full textTappi, Silvia <1980>. "Qualitative, Metabolic and Nutritional Aspects of Traditional and Innovative Minimally Processed Fruit." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amsdottorato.unibo.it/7633/.
Full textPivovarova, Olga [Verfasser]. "Cardiovascular, inflammatory and circadian aspects of metabolic regulation in humans / Olga Pivovarova." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2017. http://d-nb.info/1149050721/34.
Full textDengel, Donald R. "Metabolic determinants of success during triathlon competition." Virtual Press, 1986. http://liblink.bsu.edu/uhtbin/catkey/452141.
Full textPatel, Kishor Kantilal. "Physiological aspects of weight loss in obesity." Thesis, University of Nottingham, 2011. http://eprints.nottingham.ac.uk/12052/.
Full textButler, Ross Norman. "Aspects of the relationship between metabolic and proliferative activity in the large bowel /." Title page, contents and abstract only, 1990. http://web4.library.adelaide.edu.au/theses/09PH/09phb986.pdf.
Full textTrichia, Eirini. "Dairy products and cardio-metabolic health : aspects from nutritional, molecular and genetic epidemiology." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/290034.
Full textSocha, Catherine. "Study of the metabolic aspects of resilience to intestinal infections in Drosophila melanogaster." Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAJ106.
Full textUpon microbial infections, host defenses comprise two complementary facets. First, immune effectors target and kill the invading pathogen, an attack referred to as resistance. Second, the infected host must repair the damages inflicted by microbes or by the immune response itself, a mechanism called resilience. I have studied the effects of an intestinal infection with the bacterium Serratia marcescens in Drosophila. We have discovered a purge mechanism in the intestine, where enterocytes -the main cell type in the gut- extrude some of their internal contents. The intestinal epithelium thus becomes very thin but rapidly recovers its shape, thereby protecting the fly against the deleterious effects of infection. I have identified an amino acid transporter, CG1139, which is required for the intestinal recovery. CG1139 is necessary to mobilize the fly’s internal metabolic reserves and to transport some these metabolic stores back to the gut, in a retrograde manner
Howe, Cheryl A. "The effects of warm-up intensity on anaerobic performance and metabolic recovery in male children." Virtual Press, 1994. http://liblink.bsu.edu/uhtbin/catkey/917031.
Full textSchool of Physical Education
Ramabhai, Leena I. "The effect of load carriage on selected metabolic and perceptual responses of military personnel." Thesis, Rhodes University, 2000. http://hdl.handle.net/10962/d1005189.
Full textGoh, Kah Lay. "Skin microvascular function in type 2 diabetes and related aspects of the metabolic syndrome." Thesis, University of Leicester, 2001. http://hdl.handle.net/2381/29384.
Full textNijhuis, Jeroen. "Bariatric surgery and its effect on the metabolic and inflammatory aspects of morbid obesity." Maastricht : Maastricht : Universitaire Pers Maastricht ; University Library, Universiteit Maastricht [host], 2008. http://arno.unimaas.nl/show.cgi?fid=11592.
Full textCole, Kevin J. "The effects of caffeine sensitivity on metabolic substrate use and performance." Virtual Press, 1994. http://liblink.bsu.edu/uhtbin/catkey/902503.
Full textSchool of Physical Education
Bradbury, James. "Computational hypothesis generation with genome-side metabolic reconstructions : in-silico prediction of metabolic changes in the freshwater model organism Daphnia to environmental stressors." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8437/.
Full textLaberge, MacDonald Tammy. "Molecular Aspects of Nitrogen Metabolism in Fishes." Scholarly Repository, 2009. http://scholarlyrepository.miami.edu/oa_dissertations/668.
Full textZhang, Song. "Peripheral and central pathways linking metabolic status and reproduction in male sheep." University of Western Australia. School of Animal Biology, 2005. http://theses.library.uwa.edu.au/adt-WU2005.0037.
Full textPassow, Courtney Nicole. "Physiological and transcriptomic aspects of adaptation to extreme environments." Diss., Kansas State University, 2016. http://hdl.handle.net/2097/32867.
Full textDepartment of Biology
Michael Tobler
Extremophiles are organisms with the ability to survive in environments characterized by strong physicochemical stressors lethal to most other organisms, providing excellent models to further our understanding of life's capacities and limitations to deal with far-from-average conditions. I studied how physiological processes varied among fish residing in starkly different environmental conditions to understand how organisms cope with extreme environments and disentangle the roles of short-term plastic responses and evolved population differences in shaping physiological responses. I used the Poecilia mexicana model, a series of extremophile fish populations that has colonized toxic hydrogen sulfide (H₂S) rich springs and caves, to address three major objectives: (1) I investigated the energetic consequences of life in extreme environments and tested whether predicted reductions in organismal energy demands evolved repeatedly along replicated environmental gradients. (2) I characterized variation in gene expression among populations and organs to test for interactive effects between different stressors and identify potential physiological mechanisms underlying adaptation to H₂S and cave environments. (3) I conducted common garden and H₂S-exposure experiments to test how evolutionary change and plasticity interact to shape variation in gene expression observed in nature. To address these objectives, I measured variation in metabolic physiology and quantified variation in physiological processes through genome-wide gene expression analyses. I found that adaptation to extreme environments directly impacts energy metabolism, with fish living in extreme environments consistently expending less energy overall. Reductions in energy demand have evolved in convergence and were primarily mediated through a life history shift (reduction in body mass). The quantification of gene expression across divergent habitats and organs revealed organ-specific physiological responses in H₂S-rich and cave habitats. Gene expression variation in the relevant genes was primarily shaped by evolutionary change in gene regulation, and ancestral plastic responses play a minor role in causing the observed expression differences between replicated sulfidic and nonsulfidic populations in nature. Overall, my research has implications for understanding the capacities and constraints that shape life in extreme environments and aids in our understanding of modifications in physiological pathways mediating adaptation to elevated H₂S and perpetual darkness.
Carman, Judith Anne. "The metabolic relationship between nutrition and cancer /." Title page, contents and abstract only, 1988. http://web4.library.adelaide.edu.au/theses/09PH/09phc287.pdf.
Full textHicks, Richard Wayne. "Association of metabolic and hemodynamic variables during exercise in children." Diss., The University of Arizona, 1987. http://hdl.handle.net/10150/184264.
Full textLee, Stuart M. C. "The elevation of metabolic rate after combined arm-and-leg versus leg-only exercise." Thesis, Virginia Tech, 1992. http://hdl.handle.net/10919/40646.
Full textPrevious investigations have shown that metabolic rate remains elevated for a period of time after the cessation of exercise. While other investigations have examined the effect of intensity and duration of prior exercise, the purpose of this study was to examine the effect of exercise mode and the employment of different muscle masses on the elevation of post-exercise metabolic rate (EPOC). Fifteen non-smoking, physically active females (21.1 ± 1.3 years; 21.4 ± 4.6 %BF) volunteered for this investigation. Each subject completed a graded maximal exercise test (GXT) on the Monark 880 cycle ergometer (Max HR=192.5 ± 2.3 bpm; Max V02=2.68 ± O.lll/min; Max RPE=19.5 ± 0.1) from which a heart rate corresponding to 70% V02max was chosen. Subjects then exercised on either a Monark 880 cycle ergometer (LE) or the Schwinn Airdyne (ALE) in random order for thirty minutes at the prescribed heart rate (HR). Exercise bouts were separated from each other and from the GXT by at least 48 hours. Workloads were monitored in five minute intervals and adjusted to maintain the appropriate heart rate. The mean exercise heart rates were 172.5 ± 2.8 bpm for the LE bout and 170.0 ± 2.8 bpm for the ALE bout, respectively. Two-way repeated measures ANOVA revealed no significant difference \r >0.05) between exercise treatments in terms of HR or V02. Repeated measures trend analYSis revealed no significant difference in either EPOC or post-exercise heart rate between the two treatments across a one-hour seated recovery period. There was also no significant difference (p>O.05) in excess post-exercise caloric expenditure during the recovery period as a result of the different exercise treatments. Therefore, this suggests that neither exercise modality nor the distribution of work over a larger muscle mass had an effect on EPOC when exercise intensity and duration were held constant.
Master of Science
Ledbetter, John C. "Event Order in the Biathlon Does Not Have an Effect on Metabolic Response." Thesis, University of North Texas, 1990. https://digital.library.unt.edu/ark:/67531/metadc500834/.
Full text