Journal articles: 'Meta-populations'

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Marsh, David M. "Fluctuations in amphibian populations: a meta-analysis." Biological Conservation 101, no. 3 (October 2001): 327–35. http://dx.doi.org/10.1016/s0006-3207(01)00076-3.

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Jiang, Yao, Shaoqing Tang, Wei Xiao, Peng Yun, and Xiangdong Ding. "A genome-wide association study of reproduction traits in four pig populations with different genetic backgrounds." Asian-Australasian Journal of Animal Sciences 33, no. 9 (September 1, 2020): 1400–1410. http://dx.doi.org/10.5713/ajas.19.0411.

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Objective: Genome-wide association study and two meta-analysis based on GWAS performed to explore the genetic mechanism underlying variation in pig number born alive (NBA) and total number born (TNB).Methods: Single trait GWAS and two meta-analysis (single-trait meta analysis and multitrait meta analysis) were used in our study for NBA and TNB on 3,121 Yorkshires from 4 populations, including three different American Yorkshire populations (n = 2,247) and one British Yorkshire populations (n = 874).Results: The result of single trait GWAS showed that no significant associated single nucleotide polymorphisms (SNPs) were identified. Using single-trait meta analysis and multi-trait meta analysis within populations, 11 significant loci were identified associated with target traits. Spindlin 1, vascular endothelial growth factor A, forkhead box Q1, msh homeobox 1, and LHFPL tetraspan submily member 3 are five functionally plausible candidate genes for NBA and TNB. Compared to the single population GWAS, single-trait Meta analysis can improve the detection power to identify SNPs by integrating information of multiple populations. The multiple-trait analysis reduced the power to detect trait-specific loci but enhanced the power to identify the common loci across traits.Conclusion: In total, our findings identified novel genes to be validated as candidates for NBA and TNB in pigs. Also, it enabled us to enlarge population size by including multiple populations with different genetic backgrounds and increase the power of GWAS by using meta analysis.

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Moe, Jeffry L. "Wellness and Distress in LGBTQ Populations: A Meta-Analysis." Journal of LGBT Issues in Counseling 10, no. 2 (March 10, 2016): 112–29. http://dx.doi.org/10.1080/15538605.2016.1163520.

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Pinsky, Malin L., and Stephen R. Palumbi. "Meta-analysis reveals lower genetic diversity in overfished populations." Molecular Ecology 23, no. 1 (October 25, 2013): 29–39. http://dx.doi.org/10.1111/mec.12509.

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Forrest, Robyn E., Murdoch K. McAllister, Martin W. Dorn, Steven J. D. Martell, and Richard D. Stanley. "Hierarchical Bayesian estimation of recruitment parameters and reference points for Pacific rockfishes (Sebastes spp.) under alternative assumptions about the stock–recruit function." Canadian Journal of Fisheries and Aquatic Sciences 67, no. 10 (October 2010): 1611–34. http://dx.doi.org/10.1139/f10-077.

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Hierarchical Bayesian meta-analysis can be a useful method for improving estimation of key parameters for harvested fish populations. In hierarchical models, data from multiple populations are used simultaneously to obtain estimates of parameters for individual populations and characterize the variability among populations. Many populations of Pacific rockfishes ( Sebastes spp.) have declined off the US West Coast since the 1980s, and there is also concern for their conservation in Canada. We develop a hierarchical Bayesian meta-analysis to improve estimates of stock–recruit parameters, characterize management-related parameters (e.g., optimal harvest rate), and address uncertainties in the structural form of the stock–recruit function for Pacific rockfishes. We estimate steepness and optimal harvest rates for 14 populations of Pacific rockfishes under alternative assumptions about the underlying stock–recruit function (Beverton–Holt and Ricker). We provide a posterior predictive distribution of steepness for rockfishes that can be used as a prior in future assessments for similar populations. We also evaluate whether F40% is an appropriate proxy for FMSY for Pacific rockfishes and show that uncertainty in the natural mortality rate can have a significant effect on management advice derived from meta-analyses of stock–recruit data.

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Civitello, David J., Evelyn Rynkiewicz, and Keith Clay. "Meta-Analysis of Co-Infections in Ticks." Israel Journal of Ecology and Evolution 56, no. 3-4 (May 6, 2010): 417–31. http://dx.doi.org/10.1560/ijee.56.3-4.417.

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Microbial infections typically do not occur in isolation but co-occur within diverse communities of bacteria, fungi, protozoans, and viruses. Co-infections can lead to increased disease severity, lead to selection for increased virulence, and complicate disease diagnosis and treatment. Co-infections also occur in disease vectors, and represent one source of co-infections in hosts. We examined patterns of co-infections in ticks (Order Acari), which vector diverse human and wildlife pathogens, and asked whether the frequency of microbial co-infections deviated significantly from independent associations. Most published data were from Ixodes species and reported infection and co-infection frequencies ofBorrelia burgdorferiandAnaplasma phagocytophilum. A total of 18 datasets representing 4978 adult ticks met our criteria for inclusion in the meta-analysis. Significant deviations from independent co-infection were detected in eight of the 18 populations. Five populations exhibited a significant excess ofA. phagocytophilum/B. burgdorferico-infections, including all populations ofI. ricinusthat deviated from independence. In contrast, both populations ofI. persulcatusand one of two populations ofI. scapularisexhibited a significant deficit of co-infection. The single population ofI. pacificusexamined had a significant excess of co-infection. Our meta-analyses indicate that tick-borne microbes are often distributed non-randomly, but the direction of deviation was not consistent, indicating that multiple mechanisms contribute to these patterns. Unfortunately, most published studies were not designed to describe patterns of co-infection, and provided insufficient data for our meta-analysis. Future studies should more explicitly measure and report co-infections in ticks, including co-infections by endosymbionts.

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Jujjavarapu, Chethan, Jacob Hughey, Federico Gherardini, Robert Bruggner, Garry Nolan, Sanchita Bhattacharya, and Atul Butte. "A Framework for Meta-Analysis of Cytometry Data." Journal of Immunology 196, no. 1_Supplement (May 1, 2016): 69.16. http://dx.doi.org/10.4049/jimmunol.196.supp.69.16.

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Abstract Flow cytometry has been used to analyze cell populations with a certain condition, but because of the limitations of a single flow cytometry experiment, results only present a small portion of cell populations. Meta-analysis has been used to compare and contrast multiple datasets in hopes of discovering new insights. Scientists can then identify more cell populations linked to the condition. Therefore, we are developing a method to standardize and analyze multiple flow cytometry datasets.

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Ovegård, Maria K., Niels Jepsen, Mikaela Bergenius Nord, and Erik Petersson. "Cormorant predation effects on fish populations: A global meta‐analysis." Fish and Fisheries 22, no. 3 (February 4, 2021): 605–22. http://dx.doi.org/10.1111/faf.12540.

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Gillies, Christina, Sabina Super, Hedwig te Molder, Kees de Graaf, and Annemarie Wagemakers. "Healthy eating strategies for socioeconomically disadvantaged populations: a meta-ethnography." International Journal of Qualitative Studies on Health and Well-being 16, no. 1 (January 1, 2021): 1942416. http://dx.doi.org/10.1080/17482631.2021.1942416.

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Campbell, Kate M., Angela Kouris, Whitney England, Rika E. Anderson, R. Blaine McCleskey, D. Kirk Nordstrom, and Rachel J. Whitaker. "Sulfolobus islandicus meta-populations in Yellowstone National Park hot springs." Environmental Microbiology 19, no. 6 (June 2017): 2334–47. http://dx.doi.org/10.1111/1462-2920.13728.

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Gunning, Christian E., and Helen J. Wearing. "Probabilistic measures of persistence and extinction in measles (meta)populations." Ecology Letters 16, no. 8 (June 20, 2013): 985–94. http://dx.doi.org/10.1111/ele.12124.

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Cheng, J. Y. W., E. M. L. Ng, R. Y. L. Chen, and J. S. N. Ko. "Prevalence of erectile dysfunction in Asian populations: a meta-analysis." International Journal of Impotence Research 19, no. 3 (August 24, 2006): 229–44. http://dx.doi.org/10.1038/sj.ijir.3901517.

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Spaans, Marleen, Marc L. Molendijk, Edwin de Beurs, Thomas Rinne, and Philip Spinhoven. "Self-reported personality traits in forensic populations: a meta-analysis." Psychology, Crime & Law 23, no. 1 (August 23, 2016): 56–78. http://dx.doi.org/10.1080/1068316x.2016.1220555.

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Corrigan, Patrick W. "Social skills training in adult psychiatric populations: A meta-analysis." Journal of Behavior Therapy and Experimental Psychiatry 22, no. 3 (September 1991): 203–10. http://dx.doi.org/10.1016/0005-7916(91)90017-y.

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Waseem, Andrabi Syed, Vertika Singh, Girish Chandra Makker, Sameer Trivedi, Geetanjali Mishra, Kiran Singh, and Singh Rajender. "AZF deletions in Indian populations: original study and meta-analyses." Journal of Assisted Reproduction and Genetics 37, no. 2 (January 9, 2020): 459–69. http://dx.doi.org/10.1007/s10815-019-01661-0.

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Sentenac, Mariane, Isabelle Boutron, Elizabeth S. Draper, Eero Kajantie, Rolf F. Maier, Dieter Wolke, and Jennifer Zeitlin. "Defining Very Preterm Populations for Systematic Reviews With Meta-analyses." JAMA Pediatrics 174, no. 10 (October 1, 2020): 997. http://dx.doi.org/10.1001/jamapediatrics.2020.0956.

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Mensah-Ablorh, Akweley, Sara Lindstrom, Christopher A. Haiman, Brian E. Henderson, Loic Le Marchand, Seunngeun Lee, Daniel O. Stram, A. Heather Eliassen, Alkes Price, and Peter Kraft. "Meta-Analysis of Rare Variant Association Tests in Multiethnic Populations." Genetic Epidemiology 40, no. 1 (December 7, 2015): 57–65. http://dx.doi.org/10.1002/gepi.21939.

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Veritti, Daniele, Valentina Sarao, Valentina Soppelsa, Carla Danese, Jay Chhablani, and Paolo Lanzetta. "Managing Neovascular Age-Related Macular Degeneration in Clinical Practice: Systematic Review, Meta-Analysis, and Meta-Regression." Journal of Clinical Medicine 11, no. 2 (January 10, 2022): 325. http://dx.doi.org/10.3390/jcm11020325.

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The use of anti-vascular endothelial growth factor (VEGF) agents has profoundly changed the prognosis of neovascular age-related macular degeneration (nAMD). As clinical experiences have accumulated, it has become mandatory to summarize data to give information that can be useful in everyday practice. We conducted a systematic review to identify randomized controlled trials (RCTs) and observational studies that reported 12-month changes in best-corrected visual acuity (BCVA) in patients with nAMD on anti-VEGF monotherapy. Data were analyzed in a random-effects meta-analysis with BCVA change as the primary outcome. Meta-regression was conducted to evaluate the impact of multiple covariates. Four hundred and twelve heterogeneous study populations (109,666 eyes) were included. Anti-VEGFs induced an overall improvement of +5.37 ETDRS letters at 12 months. Meta-regression showed that mean BCVA change was statistically greater for RCTs (p = 0.0032) in comparison with observational studies. Populations following a proactive regimen had better outcomes than those following a reactive treatment regimen. Mean BCVA change was greater in younger populations, with lower baseline BCVA and treated with a higher number of injections (p < 0.001). Our results confirm that anti-VEGFs may produce a significant functional improvement at 12 months in patients with nAMD.

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Wang, Qi, Shaobo Zhou, Lijie Wang, Mingming Lei, Yong Wang, Chi Miao, and Yuanzhe Jin. "ALDH2rs671 Polymorphism and Coronary Heart Disease Risk Among Asian Populations: A Meta-Analysis and Meta-Regression." DNA and Cell Biology 32, no. 7 (July 2013): 393–99. http://dx.doi.org/10.1089/dna.2013.1995.

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Cho, Y. C., J. Kim, R. C. Sokol, and G. Y. Rhee. "Biotransformation of polychlorinated biphenyls in St. Lawrence River sediments: reductive dechlorination and dechlorinating microbial populations." Canadian Journal of Fisheries and Aquatic Sciences 57, S1 (March 14, 2000): 95–100. http://dx.doi.org/10.1139/f99-239.

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Polychlorinated biphenyl dechlorinating microbial populations in St. Lawrence River sediments were fractionated and estimated based on the dechlorination pattern using a combination of serial dilution and most probable number techniques. Two distinctive dechlorination patterns were found in most probable number sediments spiked with Aroclor 1248. A high-dilution inoculum decreased the average number of chlorines per biphenyl from 4.0 to 3.4 but was unable to dechlorinate meta-substituted congeners consisting mainly of 2,5,2',5'-, 2,4,2',5'-, and 2,5,2'-chlorobiphenyl (pattern B). On the other hand, a low-dilution inoculum did dechlorinate the meta-rich congeners and reduced the average number of chlorines to 2.9 (pattern A). These results indicate that there are at least two populations. While pattern B was produced by pattern B producing dechlorinators, pattern A was produced by a combination of pattern B producers plus another population that dechlorinates the meta-substituted congeners. When the population size was calculated based on the frequency of respective dechlorination patterns, the populations yielding pattern B were approximately 2.4 × 106cells·g dry weight sediment-1whereas the dechlorinators of the meta-rich congeners were two orders of magnitude less at 3.5 × 104cells·g dry weight sediment-1. Despite lower numbers, these meta-dechlorinators in pattern A increased the overall dechlorination by almost twofold.

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Al Kanaani, Zaina, Sarwat Mahmud, Silva P. Kouyoumjian, and Laith J. Abu-Raddad. "The epidemiology of hepatitis C virus in Pakistan: systematic review and meta-analyses." Royal Society Open Science 5, no. 4 (April 2018): 180257. http://dx.doi.org/10.1098/rsos.180257.

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To characterize hepatitis C virus (HCV) epidemiology in Pakistan and estimate the pooled mean HCV antibody prevalence in different risk populations, we systematically reviewed all available records of HCV incidence and/or prevalence from 1989 to 2016, as informed by the Cochrane Collaboration Handbook. This systematic review was reported following the PRISMA guidelines. Populations were classified into six categories based on the risk of exposure to HCV infection. Meta-analyses were performed using DerSimonian and Laird random-effects models with inverse variance weighting. The search identified one HCV incidence study and 341 prevalence measures/strata. Meta-analyses estimated the pooled mean HCV prevalence at 6.2% among the general population, 34.5% among high-risk clinical populations, 12.8% among populations at intermediate risk, 16.9% among special clinical populations, 55.9% among populations with liver-related conditions and 53.6% among people who inject drugs. Most reported risk factors in analytical epidemiologic studies related to healthcare procedures. Pakistan is enduring an HCV epidemic of historical proportions—one in every 20 Pakistanis is infected. HCV plays a major role in liver disease burden in this country, and HCV prevalence is high in all-risk populations. Most transmission appears to be driven by healthcare procedures. HCV treatment and prevention must become a national priority.

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Buglione, Maria, Simona Petrelli, Claudia Troiano, Tommaso Notomista, Antonio Petrella, Laura De Riso, Luigi Poerio, Vito Cascini, Remo Bartolomei, and Domenico Fulgione. "Spatial genetic structure in the Eurasian otter (Lutra lutra) meta-population from its core range in Italy." Contributions to Zoology 90, no. 1 (August 28, 2020): 70–92. http://dx.doi.org/10.1163/18759866-bja10012.

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Abstract We characterized the genetic structure of the Eurasian otter (Lutra lutra) meta-population living in the core of its Italian distribution range providing results from 191 fresh spraints, collected from 24 watercourses included in Southern Italy. Furthermore, according to ecological corridors and barriers, we discuss the likely ways of movement and possible evolutionary fate of these populations. We genotyped 136 samples using 11 Lut microsatellite nuclear markers amplified from faecal dna. Microsatellites were moderately variable (Ho = 0.45; He = 0.46), with a total number of alleles and average number of alleles per locus in the meta-population of 50 and 4.54, respectively. No significant heterozygosity excess was observed in meta-population suggesting no recent population bottlenecks. Bayesian clustering discriminated a sub-structuring of the meta-population in five putative clusters, indicating that local populations are genetically differentiated: three of these seem to be identifiable with geographically defined sub-populations (from the Cilento, Agri and Basento river basins). The fourth is represented by multiple sub-populations with admixed genotype, that include genotypes from the Lao, Sinni and Abatemaco river basins, living in a landscape with the higher environmental permeability. Landscape genetic analysis could provide evidence of an unexpected ecological corridor: the seacoast, highlighted, for the first time as a new way for the dispersion of the South-Italian otters. Deepening the knowledge of these perspectives is crucial to identify solid strategies aimed at the future health of the populations of the Italian otters, by restoring dispersal corridors and managing the watercourses.

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Young, S., D. Moss, O. Sedgwick, M. Fridman, and P. Hodgkins. "A meta-analysis of the prevalence of attention deficit hyperactivity disorder in incarcerated populations." Psychological Medicine 45, no. 2 (April 7, 2014): 247–58. http://dx.doi.org/10.1017/s0033291714000762.

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BackgroundStudies report the variable prevalence of attention deficit hyperactivity disorder (ADHD) in incarcerated populations. The aim of this meta-analysis was to determine the prevalence of ADHD in these populations.MethodPrimary research studies reporting the prevalence (lifetime/current) of ADHD in incarcerated populations were identified. The meta-analysis used a mixed log-binomial model, including fixed effects for each covariate and a random study effect, to estimate the significance of various risk factors.ResultsForty-two studies were included in the analysis. ADHD prevalence was higher with screening diagnoses versus diagnostic interview (and with retrospective youth diagnoses versus current diagnoses). Using diagnostic interview data, the estimated prevalence was 25.5% and there were no significant differences for gender and age. Significant country differences were noted.ConclusionsCompared with published general population prevalence, there is a fivefold increase in prevalence of ADHD in youth prison populations (30.1%) and a 10-fold increase in adult prison populations (26.2%).

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Van Zandt and Mopper. "A Meta-Analysis of Adaptive Deme Formation in Phytophagous Insect Populations." American Naturalist 152, no. 4 (1998): 595. http://dx.doi.org/10.2307/2463359.

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Tohme, Scarlett, Shangqing Jiang, Amee Shah, Lindsay Freud, Giovanni Ferrari, Emile Bacha, and David Kalfa. "Ross Procedure in Neonate and Infant Populations: A Meta-analysis Review." Structural Heart 3, sup1 (April 9, 2019): 116–17. http://dx.doi.org/10.1080/24748706.2019.1588540.

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Lifshitz, Hefziba, Sarit Shtein, Izhak Weiss, and Eli Vakil. "Meta‐analysis of explicit memory studies in populations with intellectual disability." European Journal of Special Needs Education 26, no. 1 (February 2011): 93–111. http://dx.doi.org/10.1080/08856257.2011.543535.

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Province, M. A., M. P. Goetz, H. Brauch, D. A. Flockhart, J. M. Hebert, R. Whaley, V. J. Suman, et al. "CYP2D6 Genotype and Adjuvant Tamoxifen: Meta-Analysis of Heterogeneous Study Populations." Clinical Pharmacology & Therapeutics 95, no. 2 (September 23, 2013): 216–27. http://dx.doi.org/10.1038/clpt.2013.186.

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Gonser, M., K. Vetter, F. Noack, and KennethF Schulz. "Meta-analyses of interventional trials done in populations with different risks." Lancet 345, no. 8960 (May 1995): 1304–5. http://dx.doi.org/10.1016/s0140-6736(95)90949-4.

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Young, S., O. Sedgwick, M. Fridman, G. Gudjonsson, P. Hodgkins, M. Lantigua, and R. A. González. "Co-morbid psychiatric disorders among incarcerated ADHD populations: a meta-analysis." Psychological Medicine 45, no. 12 (April 10, 2015): 2499–510. http://dx.doi.org/10.1017/s0033291715000598.

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BackgroundRates of psychiatric disorders are highly prevalent among prison inmates, and recent evidence confirms over-representation of youths and adults with attention deficit hyperactivity disorder (ADHD). The risk for psychiatric co-morbidity may be greater among offenders with ADHD. We undertook a systematic review and meta-analysis of reported rates of co-existing psychiatric morbidity with ADHD in prison samples.MethodStudies published from 1980 to 2015 were identified using five bibliographic indexes, review articles and reference lists. Included studies had a defined ADHD group and provided additional prevalence on at least one of the following: conduct disorder, substance use disorder, mood disorder, anxiety disorder, or personality disorder. We performed meta-analytical estimates of the prevalence of each co-morbid disorder within ADHD, and estimated the risk for co-existing disorders among prisoners with ADHD by pooling odds ratios (OR) with 95% confidence intervals.ResultsEighteen studies with data for 1615 with ADHD and 3128 without ADHD were included. The risk (OR) of all psychiatric morbidity is increased among adult inmates with ADHD. Associations in youths with ADHD were restricted to mood disorder (OR 1.89, 95% confidence interval 1.09–3.28).ConclusionsThis study quantifies the extent of co-morbidity presented by offenders with ADHD, especially adults. The differences between risk estimates for youths and adults indicate an incremental effect in both frequency and severity for the development of further co-morbid pathology through adulthood. The findings have implications for clinical intervention and for criminal justice policy.

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Zandt, Peter A. Van, and Susan Mopper. "A Meta‐Analysis of Adaptive Deme Formation in Phytophagous Insect Populations." American Naturalist 152, no. 4 (October 1998): 595–604. http://dx.doi.org/10.1086/286192.

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Marsh, Abigail A., and R. J. R. Blair. "Deficits in facial affect recognition among antisocial populations: A meta-analysis." Neuroscience & Biobehavioral Reviews 32, no. 3 (January 2008): 454–65. http://dx.doi.org/10.1016/j.neubiorev.2007.08.003.

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Boler, A., and P. Howard. "MD3 THE IMPLICATIONS OF COMBINING HETEROGENEOUS PATIENT POPULATIONS IN META-ANALYSES." Value in Health 6, no. 6 (November 2003): 610–11. http://dx.doi.org/10.1016/s1098-3015(10)61569-0.

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Band, Gavin, Quang Si Le, Luke Jostins, Matti Pirinen, Katja Kivinen, Muminatou Jallow, Fatoumatta Sisay-Joof, et al. "Imputation-Based Meta-Analysis of Severe Malaria in Three African Populations." PLoS Genetics 9, no. 5 (May 23, 2013): e1003509. http://dx.doi.org/10.1371/journal.pgen.1003509.

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Tohme, Scarlett, Shangqing Jiang, Kanwal Farooqi, Matthew A. Crystal, David Blitzer, Giovanni Ferrari, Emile Bacha, and David Kalfa. "Ross Procedure in Neonate and Infant Populations: A Meta-Analysis Review." World Journal for Pediatric and Congenital Heart Surgery 13, no. 6 (October 26, 2022): 759–69. http://dx.doi.org/10.1177/21501351221119494.

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Objective This study aims to perform a meta-analysis of early and late outcomes of the Ross/Ross-Konno procedures in neonates/infants. Methods A meta-analysis was performed in accordance with PRISMA guidelines. We used Ovid versions of MEDLINE/PubMed for relevant studies and included those that reported Ross/Ross-Konno operations in neonates/infants and at least one of the predetermined clinical outcomes. I2 and double arcsine methods assessed the heterogeneity between pooled estimates. We used a random-effect model to account for heterogeneity with MetaXL. We calculated point estimates of a pooled estimates along with its 95% CI. Results 587 neonate/infant patients were included with median age of 87.5 days old. The follow-up range was five days to 23 years. Early mortality reported in 25 studies with pooled estimates of 18.3% (95% CI: 13.6%-23.5%). Estimates ranged from 0% to 50% with relatively substantial heterogeneity ( P = .01, I2 = 48.6%). Late mortality reported in 22 studies with pooled incidence of 9.7% (95% CI: 5.9%-14.3%). Estimates ranged from 0% to 53% with relatively substantial heterogeneity ( P = .01, I2 = 46.1%). Autograft reintervention reported in 18 studies with pooled estimate of 19.2% (95% CI: 7.3%-34.5%). Estimates ranged from 0% to 81.8% with high heterogeneity ( P < .001, I2 = 90.5%). Right ventricle-to-pulmonary artery conduit reintervention reported in 16 studies with pooled estimates of 32.0% (95% CI: 20.9%-44.12%). Estimates ranged from 0% to 92.3% with high heterogeneity ( P < .001, I2 = 75.9%). Conclusions The data suggest that the Ross/Ross-Konno procedure in neonates/infants still carries significant risk of early/late mortality and autograft/conduit reintervention. The high variability of results among centers confirms the need for surgical expertise and good patient selection. Prospective multicenter studies are warranted to investigate the rate of autograft reintervention and the impact on long-term survival in this specific population.

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Plock, Nele, Axel Facius, Gezim Lahu, Nolan Wood, Timothy Frigo, Aaron Deveney, and Pau Aceves. "Population Pharmacokinetic Meta-Analysis to Bridge Ferumoxytol Plasma Pharmacokinetics Across Populations." Clinical Pharmacokinetics 54, no. 4 (November 5, 2014): 385–95. http://dx.doi.org/10.1007/s40262-014-0203-9.

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Chen, Zi, Wei-Ying Li, Mandy Ho, and Pui-Hing Chau. "The Prevalence of Sarcopenia in Chinese Older Adults: Meta-Analysis and Meta-Regression." Nutrients 13, no. 5 (April 24, 2021): 1441. http://dx.doi.org/10.3390/nu13051441.

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Sarcopenia, with risk factors such as poor nutrition and physical inactivity, is becoming prevalent among the older population. The aims of this study were (i) to systematically review the existing data on sarcopenia prevalence in the older Chinese population, (ii) to generate pooled estimates of the sex-specific prevalence among different populations, and (iii) to identify the factors associated with the heterogeneity in the estimates across studies. A search was conducted in seven databases for studies that reported the prevalence of sarcopenia in Chinese older adults, aged 60 years and over, published through April 2020. We then performed a meta-analysis to estimate the pooled prevalence, and investigated the factors associated with the variation in the prevalence across the studies using meta-regression. A total of 58 studies were included in this review. Compared with community-dwelling Chinese older adults (men: 12.9%, 95% CI: 10.7–15.1%; women: 11.2%, 95% CI: 8.9–13.4%), the pooled prevalence of sarcopenia in older adults from hospitals (men: 29.7%, 95% CI:18.4–41.1%; women: 23.0%, 95% CI:17.1–28.8%) and nursing homes (men: 26.3%, 95% CI: 19.1 to 33.4%; women: 33.7%, 95% CI: 27.2 to 40.1%) was higher. The multivariable meta-regression quantified the difference of the prevalence estimates in different populations, muscle mass assessments, and areas. This study yielded pooled estimates of sarcopenia prevalence in Chinese older adults not only from communities, but also from clinical settings and nursing homes. This study added knowledge to the current epidemiology literature about sarcopenia in older Chinese populations, and could provide background information for future preventive strategies, such as nutrition and physical activity interventions, tailored to the growing older population.

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Lasram, Khaled, Nizar Ben Halim, Sana Hsouna, Rym Kefi, Imen Arfa, Welid Ghazouani, Henda Jamoussi, et al. "Evidence for Association of the E23K Variant ofKCNJ11Gene with Type 2 Diabetes in Tunisian Population: Population-Based Study and Meta-Analysis." BioMed Research International 2014 (2014): 1–9. http://dx.doi.org/10.1155/2014/265274.

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Aims. Genetic association studies have reported the E23K variant ofKCNJ11gene to be associated with Type 2 diabetes. In Arab populations, only four studies have investigated the role of this variant. We aimed to replicate and validate the association between the E23K variant and Type 2 diabetes in Tunisian and Arab populations.Methods. We have performed a case-control association study including 250 Tunisian patients with Type 2 diabetes and 267 controls. Allelic association has also been evaluated by 2 meta-analyses including all population-based studies among Tunisians and Arabs (2 and 5 populations, resp.).Results. A significant association between the E23K variant and Type 2 diabetes was found (OR = 1.6, 95% CI = 1.14–2.27, andP=0.007). Furthermore, our meta-analysis has confirmed the significant role of the E23K variant in susceptibility of Type 2 diabetes in Tunisian and Arab populations (OR = 1.29, 95% CI = 1.15–1.46, andP<10-3and OR = 1.33, 95% CI = 1.13–1.56, andP=0.001, resp.).Conclusion. Both case-control and meta-analyses results revealed the significant association between the E23K variant ofKCNJ11and Type 2 diabetes among Tunisians and Arabs.

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Sultana, Bushra, Marie-Andrée Panzini, Ariane Veilleux Carpentier, Jacynthe Comtois, Bastien Rioux, Geneviève Gore, Prisca R. Bauer, et al. "Incidence and Prevalence of Drug-Resistant Epilepsy." Neurology 96, no. 17 (March 15, 2021): 805–17. http://dx.doi.org/10.1212/wnl.0000000000011839.

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ObjectiveTo evaluate the incidence and prevalence of drug-resistant epilepsy (DRE) as well as its predictors and correlates, we conducted a systematic review and meta-analysis of observational studies.MethodsOur protocol was registered with PROSPERO, and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses and Meta-analysis of Observational Studies in Epidemiology reporting standards were followed. We searched MEDLINE, Embase, and Web of Science. We used a double arcsine transformation and random-effects models to perform our meta-analyses. We performed random-effects meta-regressions using study-level data.ResultsOur search strategy identified 10,794 abstracts. Of these, 103 articles met our eligibility criteria. There was high interstudy heterogeneity and risk of bias. The cumulative incidence of DRE was 25.0% (95% confidence interval [CI]: 16.8–34.3) in child studies but 14.6% (95% CI: 8.8–21.6) in adult/mixed age studies. The prevalence of DRE was 13.7% (95% CI: 9.2–19.0) in population/community-based populations but 36.3% (95% CI: 30.4–42.4) in clinic-based cohorts. Meta-regression confirmed that the prevalence of DRE was higher in clinic-based populations and in focal epilepsy. Multiple predictors and correlates of DRE were identified. The most reported of these were having a neurologic deficit, an abnormal EEG, and symptomatic epilepsy. The most reported genetic predictors of DRE were polymorphisms of the ABCB1 gene.ConclusionsOur observations provide a basis for estimating the incidence and prevalence of DRE, which vary between populations. We identified numerous putative DRE predictors and correlates. These findings are important to plan epilepsy services, including epilepsy surgery, a crucial treatment option for people with disabling seizures and DRE.

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Barley, Jordanna M., Brian S. Cheng, Matthew Sasaki, Sarah Gignoux-Wolfsohn, Cynthia G. Hays, Alysha B. Putnam, Seema Sheth, Andrew R. Villeneuve, and Morgan Kelly. "Limited plasticity in thermally tolerant ectotherm populations: evidence for a trade-off." Proceedings of the Royal Society B: Biological Sciences 288, no. 1958 (September 8, 2021): 20210765. http://dx.doi.org/10.1098/rspb.2021.0765.

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Many species face extinction risks owing to climate change, and there is an urgent need to identify which species' populations will be most vulnerable. Plasticity in heat tolerance, which includes acclimation or hardening, occurs when prior exposure to a warmer temperature changes an organism's upper thermal limit. The capacity for thermal acclimation could provide protection against warming, but prior work has found few generalizable patterns to explain variation in this trait. Here, we report the results of, to our knowledge, the first meta-analysis to examine within-species variation in thermal plasticity, using results from 20 studies (19 species) that quantified thermal acclimation capacities across 78 populations. We used meta-regression to evaluate two leading hypotheses. The climate variability hypothesis predicts that populations from more thermally variable habitats will have greater plasticity, while the trade-off hypothesis predicts that populations with the lowest heat tolerance will have the greatest plasticity. Our analysis indicates strong support for the trade-off hypothesis because populations with greater thermal tolerance had reduced plasticity. These results advance our understanding of variation in populations' susceptibility to climate change and imply that populations with the highest thermal tolerance may have limited phenotypic plasticity to adjust to ongoing climate warming.

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Gatto, Nicole M., Pamela Ogata, and Brittany Lytle. "Farming, Pesticides, and Brain Cancer: A 20-Year Updated Systematic Literature Review and Meta-Analysis." Cancers 13, no. 17 (September 5, 2021): 4477. http://dx.doi.org/10.3390/cancers13174477.

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Twenty additional years of epidemiologic literature have become available since the publication of two meta-analyses on farming and brain cancer in 1998. The current systematic literature review and meta-analysis extends previous research and harmonizes findings. A random effects model was used to calculate meta-effect estimates from 52 studies (51 articles or reports), including 11 additional studies since 1998. Forty of the 52 studies reported positive associations between farming and brain cancer with effect estimates ranging from 1.03 to 6.53. The overall meta-risk estimate was 1.13 (95% CI = 1.06, 1.21), suggesting that farming is associated with a 13% increase in risk of brain cancer morbidity or mortality. Farming among white populations was associated with a higher risk of brain cancer than among non-white populations. Livestock farming (meta-RR = 1.34; 95% CI = 1.18, 1.53) was associated with a greater risk compared with crop farming (meta-RR = 1.13; 95% CI = 0.97, 1.30). Farmers with documented exposure to pesticides had greater than a 20% elevated risk of brain cancer. Despite heterogeneity among studies, we conclude that the synthesis of evidence from 40 years of epidemiologic literature supports an association between brain cancer and farming with its potential for exposure to chemical pesticides.

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Hagen, Briana N. M., Charlotte B. Winder, Jared Wootten, Carrie K. McMullen, and Andria Jones-Bitton. "A Systematic Review and Meta-Analysis of Depression among Farming Populations Worldwide." International Journal of Environmental Research and Public Health 17, no. 24 (December 15, 2020): 9376. http://dx.doi.org/10.3390/ijerph17249376.

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A systematic review and meta-analysis were conducted to determine the overall prevalence of depression among farming populations globally, and explore any heterogeneity present. Eligible studies were primary research articles published in English, which involved the collection of data for the purpose of determining the prevalence of depression among a farming population. Four relevant databases were searched in January 2019. Potential for bias was assessed using a modified Quality Assessment of Diagnostic Accuracy Studies (QUADAS) tool. From 7662 records, 72 articles were deemed relevant and had data extracted. Of these, 45 utilized the Center for Epidemiologic Studies—Depression Revised scale (CES-D/DR) to quantify depression, 42 of which were conducted in the United States (U.S.). As a result, meta-analyses were restricted to this geographic location. Substantial heterogeneity was seen in the initial whole-group analysis (I2 = 97%), and while sub-group exploration suggested a significantly higher prevalence of depression among migrant farm workers (26%, 95% CI = 21–31%) than in studies examining a non-migrant farming population (12%, 95% CI = 8–17%), substantial heterogeneity remained (I2 = 96%), indicating that the majority of between study variation was due to factors other than sampling error. Additionally, the majority of studies (81%) in migrant farm worker populations were published since 2010, while only 21% of studies in non-migrant farming populations were published in this timeframe. It is possible with recent efforts to de-stigmatize mental illness, participants in more recent studies may be more likely to self-report depressive symptoms. Hence, while it appears that migrant farmworker populations may have an elevated prevalence of depression, it is also apparent that little research in the U.S. has been done to evaluate depression among non-migrant farming populations in recent years. Perhaps a reporting bias may account for some of the difference between the two populations. A research gap also appears to exist in estimating the prevalence of depression among farming populations outside of the US. Assessment for bias at the study level revealed challenges in reporting of key study design elements, as well as potential for selection bias in the majority of studies.

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Hubers, A. A. M., S. Moaddine, S. H. M. Peersmann, T. Stijnen, E. van Duijn, R. C. van der Mast, O. M. Dekkers, and E. J. Giltay. "Suicidal ideation and subsequent completed suicide in both psychiatric and non-psychiatric populations: a meta-analysis." Epidemiology and Psychiatric Sciences 27, no. 2 (December 19, 2016): 186–98. http://dx.doi.org/10.1017/s2045796016001049.

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Aims.Several authors claimed that expression of suicidal ideation is one of the most important predictors of completed suicide. However, the strength of the association between suicidal ideation and subsequent completed suicide has not been firmly established in different populations. Furthermore, the absolute suicide risk after expression of suicidal ideation is unknown. In this meta-analysis, we examined whether the expression of suicidal ideation predicted subsequent completed suicide in various populations, including both psychiatric and non-psychiatric populations.Methods.A meta-analysis of cohort and case–control studies that assessed suicidal ideation as determinant for completed suicide in adults. Two independent reviewers screened 5726 articles for eligibility and extracted data of the 81 included studies. Pooled risk ratios were estimated in a random effects model stratified for different populations. Meta-regression analysis was used to determine suicide risk during the first year of follow-up.Results.The risk for completed suicide was clearly higher in people who had expressed suicidal ideation compared with people who had not, with substantial variation between the different populations: risk ratio ranging from 2.35 (95% confidence interval (CI) 1.43–3.87) in affective disorder populations to 8.00 (95% CI 5.46–11.7) in non-psychiatric populations. In contrast, the suicide risk after expression of suicidal ideation in the first year of follow-up was higher in psychiatric patients (risk 1.40%, 95% CI 0.74–2.64) than in non-psychiatric participants (risk 0.23%, 95% CI 0.10–0.54). Past suicide attempt-adjusted risk ratios were not pooled due to large underreporting.Conclusions.Assessment of suicidal ideation is of priority in psychiatric patients. Expression of suicidal ideation in psychiatric patients should prompt secondary prevention strategies to reduce their substantial increased risk of suicide.

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Christie, Mark R., Patrick G. Meirmans, Oscar E. Gaggiotti, Robert J. Toonen, and Crow White. "Disentangling the relative merits and disadvantages of parentage analysis and assignment tests for inferring population connectivity." ICES Journal of Marine Science 74, no. 6 (April 7, 2017): 1749–62. http://dx.doi.org/10.1093/icesjms/fsx044.

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AbstractAccurately estimating patterns of population connectivity in marine systems remains an elusive goal. Current genetic approaches have focused on assigning individuals back to their natal populations using one of two methods: parentage analyses and assignment tests. Each of these approaches has their relative merits and weaknesses. Here, we illustrate these tradeoffs using a forward-time agent-based model that incorporates relevant natural history and physical oceanography for 135 Kellet’s whelk (Kelletia kelletii) populations from Southern California. Like most marine organisms, Kellet’s whelks live in large meta-populations where local populations are connected by dispersive larvae. For estimating population connectivity, we found parentage analyses to be relatively insensitive to the amount of genetic differentiation among local populations, but highly sensitive to the proportion of the meta-population sampled. Assignment tests, on the other hand, were relatively insensitive to the proportion of the meta-population sampled, but highly sensitive to the amount of genetic differentiation found among local populations. Comparisons between the true connectivity matrices (generated by using the true origin of all sampled individuals) and those obtained via parentage analyses and assignment tests reveal that neither approach can explain >26% of the variation in true connectivity. Furthermore, even with perfect assignment of all sampled individuals, sampling error alone can introduce noise into the estimated population connectivity matrix. Future work should aim to improve the number of correct assignments without the expense of additional incorrect assignments, perhaps by using dispersal information obtained from related individuals as priors in a Bayesian framework. These analyses dispel a number of common misconceptions in the field and highlight areas for both future research and methodological improvements.

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Tourjman, Valerie, Gill Louis-Nascan, Ghalib Ahmed, Anaïs DuBow, Hubert Côté, Nadia Daly, George Daoud, et al. "Psychosocial Interventions for Attention Deficit/Hyperactivity Disorder: A Systematic Review and Meta-Analysis by the CADDRA Guidelines Work GROUP." Brain Sciences 12, no. 8 (August 1, 2022): 1023. http://dx.doi.org/10.3390/brainsci12081023.

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Multiple psychosocial interventions to treat ADHD symptoms have been developed and empirically tested. However, no clear recommendations exist regarding the utilization of these interventions for treating core ADHD symptoms across different populations. The objective of this systematic review and meta-analysis by the CADDRA Guidelines work Group was to generate such recommendations, using recent evidence. Randomized controlled trials (RCT) and meta-analyses (MA) from 2010 to 13 February 020 were searched in PubMed, PsycINFO, EMBASE, EBM Reviews and CINAHL. Studies of populations with significant levels of comorbidities were excluded. Thirty-one studies were included in the qualitative synthesis (22 RCT, 9 MA) and 24 studies (19 RCT, 5 MA) were included in the quantitative synthesis. Using three-level meta-analyses to pool results of multiple observations from each RCT, as well as four-level meta-analyses to pool results from multiples outcomes and multiple studies of each MA, we generated recommendations using the GRADE approach for: Cognitive Behavioral Therapy; Physical Exercise and Mind–Body intervention; Caregiver intervention; School-based and Executive intervention; and other interventions for core ADHD symptoms across Preschooler, Child, Adolescent and Adult populations. The evidence supports a recommendation for Cognitive Behavioral Therapy for adults and Caregiver intervention for Children, but not for preschoolers. There were not enough data to provide recommendations for the other types of psychosocial interventions. Our results are in line with previous meta-analytic assessments; however, they provide a more in-depth assessment of the effect of psychosocial intervention on core ADHD symptoms.

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Ye, Yu, Chong Yang, Lei Xu, and Dilong Fang. "MUC1 rs4072037 Polymorphism is Associated with Decreased Risk of Gastric Cancer: A Meta-analysis." International Journal of Biological Markers 32, no. 3 (July 2017): 284–90. http://dx.doi.org/10.5301/ijbm.5000270.

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Background Several studies have recently investigated the association between mucin 1 (MUC1) rs4072037 polymorphism and gastric cancer (GC) risk, but with conflicting results. The aim of this meta-analysis was to evaluate the association between MUC1 rs4072037 polymorphism and GC risk. Methods A comprehensive database search of PubMed, Elsevier, Embase and China National Knowledge Infrastructure (CNKI) databases was performed to identify relevant studies. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of any association. Results A total of 12 papers containing 18 studies were included in this meta-analysis, involving 12,373 cases and 15,008 controls. Our data suggested that rs4072037 polymorphism was associated with a decreased risk of GC. Stratification analyses of ethnicity indicated that rs4072037 decreased the risk of GC among white populations, but no significant relationship was observed among Asian populations. No significant associations were observed in subgroups of Lauren classification (intestinal or diffuse) and anatomical classification (cardia or non-cardia). Conclusions In conclusion, this meta-analysis suggested that rs4245739 polymorphism in the MUC1 gene may play a pivotal role in the pathogenesis of GC, especially for white populations.

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Villalobos-Comparán, Marisela, Rogelio F. Jiménez-Ortega, Karol Estrada, Alma Y. Parra-Torres, Anahí González-Mercado, Nelly Patiño, Manuel Castillejos-López, et al. "A Pilot Genome-Wide Association Study in Postmenopausal Mexican-Mestizo Women Implicates the RMND1/CCDC170 Locus Is Associated with Bone Mineral Density." International Journal of Genomics 2017 (2017): 1–13. http://dx.doi.org/10.1155/2017/5831020.

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To identify genetic variants influencing bone mineral density (BMD) in the Mexican-Mestizo population, we performed a GWAS for femoral neck (FN) and lumbar spine (LS) in Mexican-Mestizo postmenopausal women. In the discovery sample, 300,000 SNPs were genotyped in a cohort of 411 postmenopausal women and seven SNPs were analyzed in the replication cohort (n=420). The combined results of a meta-analysis from the discovery and replication samples identified two loci, RMND1 (rs6904364, P=2.77×10−4) and CCDC170 (rs17081341, P=1.62×10−5), associated with FN BMD. We also compared our results with those of the Genetic Factors for Osteoporosis (GEFOS) Consortium meta-analysis. The comparison revealed two loci previously reported in the GEFOS meta-analysis: SOX6 (rs7128738) and PKDCC (rs11887431) associated with FN and LS BMD, respectively, in our study population. Interestingly, rs17081341 rare in Caucasians (minor allele frequency < 0.03) was found in high frequency in our population, which suggests that this association could be specific to non-Caucasian populations. In conclusion, the first pilot Mexican GWA study of BMD confirmed previously identified loci and also demonstrated the importance of studying variability in diverse populations and/or specific populations.

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Alexander, Dominik D., Susan T. Pastula, and Alexander S. Riordan. "Epidemiology of lung cancer among acrylonitrile-exposed study populations: A meta-analysis." Regulatory Toxicology and Pharmacology 122 (June 2021): 104896. http://dx.doi.org/10.1016/j.yrtph.2021.104896.

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Nath, Sonia, Brianna Poirier, Xiangqun Ju, Kostas Kapellas, Dandara Haag, and Lisa Jamieson. "Periodontal disease inequities among Indigenous populations: A systematic review and meta‐analysis." Journal of Periodontal Research 57, no. 1 (October 16, 2021): 11–29. http://dx.doi.org/10.1111/jre.12942.

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Nath, Sonia, Brianna Faye Poirier, Xiangqun Ju, Kostas Kapellas, Dandara Gabriela Haag, Pedro Henrique Ribeiro Santiago, and Lisa M. Jamieson. "Dental Health Inequalities among Indigenous Populations: A Systematic Review and Meta-Analysis." Caries Research 55, no. 4 (2021): 268–87. http://dx.doi.org/10.1159/000516137.

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The aim of this systematic review and meta-analysis was to document the disparity in dental caries experiences among indigenous and nonindigenous populations globally by measuring dental caries prevalence and severity. An electronic database (MEDLINE) was initially searched using relevant keywords. This was followed by use of the search string in the following electronic databases: Scopus, EBSCOhost, Cochrane, and Open Grey. Two independent reviewers conducted the study search and screening, quality assessment, and data extraction, which was facilitated using JBI SUMARI software. The primary outcome was the decayed missing filled teeth (DMFT) score and dental caries prevalence. Subgroup analysis was done by country of publication to identify causes of heterogeneity. Forest plots were used with the standardized mean difference (SMD) and publication bias was assessed using the Egger test with funnel plot construction. For the final review, 43 articles were selected and 34 were meta-analyzed. The pooled mean DMFT for both the permanent dentition (SMD = 0.26; 95% CI 0.13–0.39) and deciduous dentition (SMD = 0.67; 95% CI 0.47–0.87) was higher for the Indigenous population than for the general population. Indigenous populations experienced more decayed teeth (SMD = 0.44; 95% CI 0.25–0.62), a slightly higher number of missing teeth (SMD = 0.11< 95% CI –0.05 to 0.26), and lesser filled teeth (SMD = –0.04; 95% CI –0.20 to 0.13) than their nonindigenous counterparts. The prevalence of dental caries (SMD = 0.27; 95% CI 0.13–0.41) was higher among indigenous people. Globally, indigenous populations have a higher caries prevalence and severity than nonindigenous populations. The factors which have led to such inequities need to be examined.

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Fan, Dazhi, Si Liu, Ting Yang, Shanshan Wu, Sheng Wang, Guixing Li, Zhen Zeng, et al. "Association between KIR polymorphisms and ankylosing spondylitis in populations: A meta-analysis." Modern Rheumatology 24, no. 6 (March 27, 2014): 985–91. http://dx.doi.org/10.3109/14397595.2014.894489.

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Journal articles on the topic 'Meta-populations'

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