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Journal articles on the topic 'Mesoporous Materials -Bioactive Pharmaceuticals -'

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Author: Grafiati

Published: 7 September 2023

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1

Salinas, Antonio J., and Pedro Esbrit. "Mesoporous Bioglasses Enriched with Bioactive Agents for Bone Repair, with a Special Highlight of María Vallet-Regí’s Contribution." Pharmaceutics 14, no. 1 (January 15, 2022): 202. http://dx.doi.org/10.3390/pharmaceutics14010202.

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Throughout her impressive scientific career, Prof. María Vallet-Regí opened various research lines aimed at designing new bioceramics, including mesoporous bioactive glasses for bone tissue engineering applications. These bioactive glasses can be considered a spin-off of silica mesoporous materials because they are designed with a similar technical approach. Mesoporous glasses in addition to SiO2 contain significant amounts of other oxides, particularly CaO and P2O5 and therefore, they exhibit quite different properties and clinical applications than mesoporous silica compounds. Both materials exhibit ordered mesoporous structures with a very narrow pore size distribution that are achieved by using surfactants during their synthesis. The characteristics of mesoporous glasses made them suitable to be enriched with various osteogenic agents, namely inorganic ions and biopeptides as well as mesenchymal cells. In the present review, we summarize the evolution of mesoporous bioactive glasses research for bone repair, with a special highlight on the impact of Prof. María Vallet-Regí´s contribution to the field.

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2

Purcăreanu, Bogdan, Manuela Diana Ene, Alina Moroșan, Dan Eduard Mihaiescu, Mihai Alexandru Florea, Adelina Ghica, Roxana Andreea Nita, et al. "Mesoporous Composite Bioactive Compound Delivery System for Wound-Healing Processes." Pharmaceutics 15, no. 9 (August 31, 2023): 2258. http://dx.doi.org/10.3390/pharmaceutics15092258.

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Currently, the treatment of wounds is still a challenge for healthcare professionals due to high complication incidences and social impacts, and the development of biocompatible and efficient medicines remains a goal. In this regard, mesoporous materials loaded with bioactive compounds from natural extracts have a high potential for wound treatment due to their nontoxicity, high loading capacity and slow drug release. MCM-41-type mesoporous material was synthesized by using sodium trisilicate as a silica source at room temperature and normal pressure. The synthesized mesoporous silica was characterized by using Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), N2 absorption–desorption (BET), Dynamic Light Scattering (DLS) and Fourier transform infrared spectroscopy (FT-IR), revealing a high surface area (BET, 1244 m2/g); pore diameter of approx. 2 nm; and a homogenous, ordered and hexagonal geometry (TEM images). Qualitative monitoring of the desorption degree of the Salvia officinalis (SO) extract, rich in ursolic acid and oleanolic acid, and Calendula officinalis (CO) extract, rich in polyphenols and flavones, was performed via the continuous recording of the UV-VIS spectra at predetermined intervals. The active ingredients in the new composite MCM-41/sage and marigold (MCM-41/SO&CO) were quantified by using HPLC-DAD and LC-MS-MS techniques. The evaluation of the biological composites’ activity on the wound site was performed on two cell lines, HS27 and HaCaT, naturally involved in tissue-regeneration processes. The experimental results revealed the ability to stimulate collagen biosynthesis, the enzymatic activity of the main metalloproteinases (MMP-2 and MMP-9) involved in tissue remodeling processes and the migration rate in the wound site, thus providing insights into the re-epithelializing properties of mesoporous composites.

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3

Chang, Lan, Yaqin Liu, and Chengtie Wu. "Copper-Doped Mesoporous Bioactive Glass for Photothermal Enhanced Chemotherapy." Journal of Biomedical Nanotechnology 14, no. 4 (April 1, 2018): 786–94. http://dx.doi.org/10.1166/jbn.2018.2542.

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4

Nakiou, Eirini A., Maria Lazaridou, Georgia K. Pouroutzidou, Anna Michopoulou, Ioannis Tsamesidis, Liliana Liverani, Marcela Arango-Ospina, et al. "Poly(Glycerol Succinate) as Coating Material for 1393 Bioactive Glass Porous Scaffolds for Tissue Engineering Applications." Polymers 14, no. 22 (November 19, 2022): 5028. http://dx.doi.org/10.3390/polym14225028.

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Background: Aliphatic polyesters are widely used for biomedical, pharmaceutical and environmental applications due to their high biodegradability and cost-effective production. Recently, star and hyperbranched polyesters based on glycerol and ω-carboxy fatty diacids have gained considerable interest. Succinic acid and bio-based diacids similar to glycerol are regarded as safe materials according to the US Food and Drug Administration (FDA). Bioactive glass scaffolds utilized in bone tissue engineering are relatively brittle materials. However, their mechanical properties can be improved by using polymer coatings that can further control their degradation rate, tailor their biocompatibility and enhance their performance. The purpose of this study is to explore a new biopolyester poly(glycerol succinate) (PGSuc) reinforced with mesoporous bioactive nanoparticles (MSNs) as a novel coating material to produce hybrid scaffolds for bone tissue engineering. Methods: Bioactive glass scaffolds were coated with neat PGSuc, PGSuc loaded with dexamethasone sodium phosphate (DexSP) and PGSuc loaded with DexSP-laden MSNs. The physicochemical, mechanical and biological properties of the scaffolds were also evaluated. Results: Preliminary data are provided showing that polymer coatings with and without MSNs improved the physicochemical properties of the 1393 bioactive glass scaffolds and increased the ALP activity and alizarin red staining, suggesting osteogenic differentiation potential when cultured with adipose-derived mesenchymal stem cells. Conclusions: PGSuc with incorporated MSNs coated onto 1393 bioactive glass scaffolds could be promising candidates in bone tissue engineering applications.

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5

Munir, Arooj, Danijela Marovic, Liebert Parreiras Nogueira, Roger Simm, Ali-Oddin Naemi, Sander Marius Landrø, Magnus Helgerud, et al. "Using Copper-Doped Mesoporous Bioactive Glass Nanospheres to Impart Anti-Bacterial Properties to Dental Composites." Pharmaceutics 14, no. 10 (October 20, 2022): 2241. http://dx.doi.org/10.3390/pharmaceutics14102241.

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Experimental dental resin composites containing copper-doped mesoporous bioactive glass nanospheres (Cu-MBGN) were developed to impart anti-bacterial properties. Increasing amounts of Cu-MBGN (0, 1, 5 and 10 wt%) were added to the BisGMA/TEGDMA resin matrix containing micro- and nano-fillers of inert glass, keeping the resin/filler ratio constant. Surface micromorphology and elemental analysis were performed to evaluate the homogeneous distribution of filler particles. The study investigated the effects of Cu-MBGN on the degree of conversion, polymerization shrinkage, porosity, ion release and anti-bacterial activity on S. mutans and A. naeslundii. Experimental materials containing Cu-MBGN showed a dose-dependent Cu release with an initial burst and a further increase after 28 days. The composite containing 10% Cu-MBGN had the best anti-bacterial effect on S. mutans, as evidenced by the lowest adherence of free-floating bacteria and biofilm formation. In contrast, the 45S5-containing materials had the highest S. mutans adherence. Ca release was highest in the bioactive control containing 15% 45S5, which correlated with the highest number of open porosities on the surface. Polymerization shrinkage was similar for all tested materials, ranging from 3.8 to 4.2%, while the degree of conversion was lower for Cu-MBGN materials. Cu-MBGN composites showed better anti-bacterial properties than composites with 45S5 BG.

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6

Ilyas, Kanwal, Lamia Singer, Muhammad Akhtar, Christoph Bourauel, and Aldo Boccaccini. "Boswellia sacra Extract-Loaded Mesoporous Bioactive Glass Nano Particles: Synthesis and Biological Effects." Pharmaceutics 14, no. 1 (January 5, 2022): 126. http://dx.doi.org/10.3390/pharmaceutics14010126.

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Bioactive glasses (BGs) are being increasingly considered for numerous biomedical applications. The loading of natural compounds onto BGs to increase the BG biological activity is receiving increasing attention. However, achieving efficient loading of phytotherapeutic compounds onto the surface of bioactive glass is challenging. The present work aimed to prepare novel amino-functionalized mesoporous bioactive glass nanoparticles (MBGNs) loaded with the phytotherapeutic agent Boswellia sacra extract. The prepared amino-functionalized MBGNs showed suitable loading capacity and releasing time. MBGNs (nominal composition: 58 wt% SiO2, 37 wt% CaO, 5 wt% P2O5) were prepared by sol-gel-modified co-precipitation method and were successfully surface-modified by using 3-aminopropyltriethoxysilane (APTES). In order to evaluate MBGNs loaded with Boswellia sacra, morphological analysis, biological studies, physico-chemical and release studies were performed. The successful functionalization and loading of the natural compound were confirmed with FTIR, zeta-potential measurements and UV-Vis spectroscopy, respectively. Structural and morphological evaluation of MBGNs was done by XRD, SEM and BET analyses, whereas the chemical analysis of the plant extract was done using GC/MS technique. The functionalized MBGNs showed high loading capacity as compared to non-functionalized MBGNs. The release studies revealed that Boswellia sacra molecules were released via controlled diffusion and led to antibacterial effects against S. aureus (Gram-positive) bacteria. Results of cell culture studies using human osteoblastic-like cells (MG-63) indicated better cell viability of the Boswellia sacra-loaded MBGNs as compared to the unloaded MBGNs. Therefore, the strategy of combining the properties of MBGNs with the therapeutic effects of Boswellia sacra represents a novel, convenient step towards the development of phytotherapeutic-loaded antibacterial, inorganic materials to improve tissue healing and regeneration.

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Simanek, Eric E. "Two Decades of Triazine Dendrimers." Molecules 26, no. 16 (August 6, 2021): 4774. http://dx.doi.org/10.3390/molecules26164774.

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For two decades, methods for the synthesis and characterization of dendrimers based on [1,3,5]-triazine have been advanced by the group. Motivated by the desire to generate structural complexity on the periphery, initial efforts focused on convergent syntheses, which yielded pure materials to generation three. To obtain larger generations of dendrimers, divergent strategies were pursued using iterative reactions of monomers, sequential additions of triazine and diamines, and ultimately, macromonomers. Strategies for the incorporation of bioactive molecules using non-covalent and covalent strategies have been explored. These bioactive materials included small molecule drugs, peptides, and genetic material. In some cases, these constructs were examined in both in vitro and in vivo models with a focus on targeting prostate tumor subtypes with paclitaxel conjugates. In the materials realm, the use of triazine dendrimers anchored on solid surfaces including smectite clay, silica, mesoporous alumina, polystyrene, and others was explored for the separation of volatile organics from gas streams or the sequestration of atrazine from solution. The combination of these organics with metal nanoparticles has been probed. The goal of this review is to summarize these efforts.

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8

Gonzalez, Gema, Amaya Sagarzazu, and Tamara Zoltan. "Infuence of Microstructure in Drug Release Behavior of Silica Nanocapsules." Journal of Drug Delivery 2013 (August 6, 2013): 1–8. http://dx.doi.org/10.1155/2013/803585.

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Meso- and nanoporous structures are adequate matrices for controlled drug delivery systems, due to their large surface areas and to their bioactive and biocompatibility properties. Mesoporous materials of type SBA-15, synthesized under different pH conditions, and zeolite beta were studied in order to compare the different intrinsic morphological characteristics as pore size, pore connectivity, and pore geometry on the drug loading and release process. These materials were characterized by X-ray diffraction, nitrogen adsorption, scanning and transmission electron microscopy, and calorimetric measurements. Ibuprofen (IBU) was chosen as a model drug for the formulation of controlled-release dosage forms; it was impregnated into these two types of materials by a soaking procedure during different periods. Drug loading and release studies were followed by UV-Vis spectrophotometry. All nano- and mesostructured materials showed a similar loading behavior. It was found that the pore size and Al content strongly influenced the release process. These results suggest that the framework structure and architecture affect the drug adsorption and release properties of these materials. Both materials offer a good potential for a controlled delivery system of ibuprofen.

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9

Tsamesidis, Ioannis, Anna Theocharidou, Anastasia Beketova, Maria Bousnaki, Iason Chatzimentor, Georgia K. Pouroutzidou, Dimitrios Gkiliopoulos, and Eleana Kontonasaki. "Artemisinin Loaded Cerium-Doped Nanopowders Improved In Vitro the Biomineralization in Human Periodontal Ligament Cells." Pharmaceutics 15, no. 2 (February 15, 2023): 655. http://dx.doi.org/10.3390/pharmaceutics15020655.

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Background: A promising strategy to enhance bone regeneration is the use of bioactive materials doped with metallic ions with therapeutic effects and their combination with active substances and/or drugs. The aim of the present study was to investigate the osteogenic capacity of human periodontal ligament cells (hPDLCs) in culture with artemisinin (ART)-loaded Ce-doped calcium silicate nanopowders (NPs); Methods: Mesoporous silica, calcium-doped and calcium/cerium-doped silicate NPs were synthesized via a surfactant-assisted cooperative self-assembly process. Human periodontal ligament cells (hPDLCs) were isolated and tested for their osteogenic differentiation in the presence of ART-loaded and unloaded NPs through alkaline phosphatase (ALP) activity and Alizarine red S staining, while their antioxidant capacity was also evaluated; Results: ART promoted further the osteogenic differentiation of hPDLCs in the presence of Ce-doped NPs. Higher amounts of Ce in the ART-loaded NPs inversely affected the mineral deposition process by the hPDLCs. ART and Ce in the NPs have a synergistic role controlling the redox status and reducing ROS production from the hPDLCs; Conclusions: By monitoring the Ce amount and ART concentration, mesoporous NPs with optimum properties can be developed towards bone tissue regeneration demonstrating also potential application in periodontal tissue regeneration strategies.

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10

Carrozza, Debora, Gianluca Malavasi, and Erika Ferrari. "Very Large Pores Mesoporous Silica as New Candidate for Delivery of Big Therapeutics Molecules, Such as Pharmaceutical Peptides." Materials 16, no. 11 (June 2, 2023): 4151. http://dx.doi.org/10.3390/ma16114151.

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The synthesis of a scaffold that can accommodate big molecules with a pharmaceutical role is important to shield them and maintain their biological activity. In this field, silica particles with large pores (LPMS) are innovative supports. Large pores allow for the loading of bioactive molecules inside the structure and contemporarily their stabilization and protection. These purposes cannot be achieved using classical mesoporous silica (MS, pore size 2–5 nm), because their pores are not big enough and pore blocking occurs. LPMSs with different porous structures are synthesized starting from an acidic water solution of tetraethyl orthosilicate reacting with pore agents (Pluronic® F127 and mesitylene), performing hydrothermal and microwave-assisted reactions. Time and surfactant optimization were performed. Loading tests were conducted using Nisin as a reference molecule (polycyclic antibacterial peptide, with dimensions of 4–6 nm); UV-Vis analyses on loading solutions were performed. For LPMSs, a significantly higher loading efficiency (LE%) was registered. Other analyses (Elemental Analysis, Thermogravimetric Analysis and UV-Vis) confirmed the presence of Nisin in all the structures and its stability when loaded on them. LPMSs showed a lower decrease in specific surface area if compared to MS; in terms of the difference in LE% between samples, it is explained considering the filling of pores for LPMSs, a phenomenon that is not allowed for MSs. Release studies in simulated body fluid highlight, only for LPMSs, a controlled release, considering the longer time scale of release. Scanning Electron Microscopy images acquired before and after release tests shows the LPMSs’ maintenance of the structure, demonstrating strength and mechanical resistance of structures. In conclusion, LPMSs were synthesized, performing time and surfactant optimization. LPMSs showed better loading and releasing properties with respect to classical MS. All collected data confirm a pore blocking for MS and an in-pore loading for LPMS.

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11

Jermjun, Kamolwan, Rujeeluk Khumho, Mookarin Thongoiam, Satit Yousatit, Toshiyuki Yokoi, Chawalit Ngamcharussrivichai, and Sakdinun Nuntang. "Natural Rubber/Hexagonal Mesoporous Silica Nanocomposites as Efficient Adsorbents for the Selective Adsorption of (−)-Epigallocatechin Gallate and Caffeine from Green Tea." Molecules 28, no. 16 (August 11, 2023): 6019. http://dx.doi.org/10.3390/molecules28166019.

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(–)-Epigallocatechin gallate (EGCG) is a bioactive component of green tea that provides many health benefits. However, excessive intake of green tea may cause adverse effects of caffeine (CAF) since green tea (30–50 mg) has half the CAF content of coffee (80–100 mg). In this work, for enhancing the health benefits of green tea, natural rubber/hexagonal mesoporous silica (NR/HMS) nanocomposites with tunable textural properties were synthesized using different amine template sizes and applied as selective adsorbents to separate EGCG and CAF from green tea. The resulting adsorbents exhibited a wormhole-like silica framework, high specific surface area (528–578 m2 g−1), large pore volume (0.76–1.45 cm3 g−1), and hydrophobicity. The NR/HMS materials adsorbed EGCG more than CAF; the selectivity coefficient of EGCG adsorption was 3.6 times that of CAF adsorption. The EGCG adsorption capacity of the NR/HMS series was correlated with their pore size and surface hydrophobicity. Adsorption behavior was well described by a pseudo-second-order kinetic model, indicating that adsorption involved H-bonding interactions between the silanol groups of the mesoporous silica surfaces and the hydroxyl groups of EGCG and the carbonyl group of CAF. As for desorption, EGCG was more easily removed than CAF from the NR/HMS surface using an aqueous solution of ethanol. Moreover, the NR/HMS materials could be reused for EGCG adsorption at least three times. The results suggest the potential use of NR/HMS nanocomposites as selective adsorbents for the enrichment of EGCG in green tea. In addition, it could be applied as an adsorbent in the filter to reduce the CAF content in green tea by up to 81.92%.

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12

Liu, Xinrui, Hsiang-Ho Chen, Yu-Chien Lin, Sasza Chyntara Nabilla, Wai-Ching Liu, Wen-Chi Wang, Shao-Ju Shih, et al. "Composite Polyelectrolyte Multilayer and Mesoporous Bioactive Glass Nanoparticle Coating on 316L Stainless Steel for Controlled Antibiotic Release and Biocompatibility." Journal of Biomedical Nanotechnology 14, no. 4 (April 1, 2018): 725–35. http://dx.doi.org/10.1166/jbn.2018.2531.

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13

Gómez-Cerezo, N., I. Izquierdo-Barba, D. Arcos, and M. Vallet-Regí. "Tailoring the biological response of mesoporous bioactive materials." Journal of Materials Chemistry B 3, no. 18 (2015): 3810–19. http://dx.doi.org/10.1039/c5tb00268k.

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14

Bernardos, A., and L. Kouřimská. "Applications of mesoporous silica materials in food – a review." Czech Journal of Food Sciences 31, No. 2 (April 18, 2013): 99–107. http://dx.doi.org/10.17221/240/2012-cjfs.

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Mesoporous silica materials have been developed for some applications in the health field. These solids are used for the controlled release of bioactive molecules, as catalysts in the synthesis of essential nutrients, as sensors to detect unhealthy products etc., with many applications in food technologies. By combining mesoporous silica materials with food, we can create healthier products, the products that improve our quality of life. The development of mesoporous materials applied to food could result in protecting bioactive molecules during their passage though the digestive system. For this reason, the controlled release of bioactive molecules is a very interesting topic for the discipline of food technology. The use of mesoporous silica supports as catalysts in the synthesis of nutrients and as sensors for the detection of unhealthy products, essential in food, is in great demand industrially for the manufacture of functional foods and films for food and industrial packaging. This review shows some examples of silica materials and their applications in food.  

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15

Kang, Min Sil, Na-Hyun Lee, Rajendra K. Singh, Nandin Mandakhbayar, Roman A. Perez, Jung-Hwan Lee, and Hae-Won Kim. "Nanocements produced from mesoporous bioactive glass nanoparticles." Biomaterials 162 (April 2018): 183–99. http://dx.doi.org/10.1016/j.biomaterials.2018.02.005.

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16

Izquierdo-Barba, Isabel, Montserrat Colilla, and María Vallet-Regí. "Nanostructured Mesoporous Silicas for Bone Tissue Regeneration." Journal of Nanomaterials 2008 (2008): 1–14. http://dx.doi.org/10.1155/2008/106970.

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The research on the development of new biomaterials that promote bone tissue regeneration is receiving great interest by the biomedical scientific community. Recent advances in nanotechnology have allowed the design of materials with nanostructure similar to that of natural bone. These materials can promote new bone formation by inducing the formation of nanocrystalline apatites analogous to the mineral phase of natural bone onto their surfaces, i.e. they are bioactive. They also stimulate osteoblast proliferation and differentiation and, therefore, accelerate the healing processes. Silica-based ordered mesoporous materials are excellent candidates to be used as third generation bioceramics that enable the adsorption and local control release of biological active agents that promote bone regeneration. This local delivery capability together with the bioactive behavior of mesoporous silicas opens up promising expectations in the bioclinical field. In this review, the last advances in nanochemistry aimed at designing and tailoring the chemical and textural properties of mesoporous silicas for biomedical applications are described. The recent developed strategies to synthesize bioactive glasses with ordered mesopore arrangements are also summarized. Finally, a deep discussion about the influence of the textural parameters and organic modification of mesoporous silicas on molecules adsorption and controlled release is performed.

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Yan, X. X., H. X. Deng, X. H. Huang, G. Q. Lu, S. Z. Qiao, D. Y. Zhao, and C. Z. Yu. "Mesoporous bioactive glasses. I. Synthesis and structural characterization." Journal of Non-Crystalline Solids 351, no. 40-42 (October 2005): 3209–17. http://dx.doi.org/10.1016/j.jnoncrysol.2005.08.024.

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18

Gisbert-Garzarán, Miguel, and María Vallet-Regí. "Nanoparticles for Bio-Medical Applications." Nanomaterials 12, no. 7 (April 2, 2022): 1189. http://dx.doi.org/10.3390/nano12071189.

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The Special Issue of Nanomaterials “Nanoparticles for Biomedical Applications” highlights the use of different types of nanoparticles for biomedical applications, including magnetic nanoparticles, mesoporous carbon nanoparticles, mesoporous bioactive glass nanoparticles, and mesoporous silica nanoparticles [...]

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19

Yun, Hui-suk, Seung-eon Kim, and Yong-taek Hyun. "Preparation of 3D cubic ordered mesoporous bioactive glasses." Solid State Sciences 10, no. 8 (August 2008): 1083–92. http://dx.doi.org/10.1016/j.solidstatesciences.2007.11.037.

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20

Vallet-Regí, María, Isabel Izquierdo-Barba, and Montserrat Colilla. "Structure and functionalization of mesoporous bioceramics for bone tissue regeneration and local drug delivery." Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 370, no. 1963 (March 28, 2012): 1400–1421. http://dx.doi.org/10.1098/rsta.2011.0258.

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This review article describes the importance of structure and functionalization in the performance of mesoporous silica bioceramics for bone tissue regeneration and local drug delivery purposes. Herein, we summarize the pivotal features of mesoporous bioactive glasses, also known as ‘templated glasses’ (TGs), which present chemical compositions similar to those of conventional bioactive sol–gel glasses and the added value of an ordered mesopore arrangement. An in-depth study concerning the possibility of tailoring the structural and textural characteristics of TGs at the nanometric scale and their influence on bioactive behaviour is discussed. The highly ordered mesoporous arrangement of cavities allows these materials to confine drugs to be subsequently released, acting as drug delivery devices. The functionalization of mesoporous silica walls has been revealed as the cornerstone in the performance of these materials as controlled release systems. The synergy between the improved bioactive behaviour and local sustained drug release capability of mesostructured materials makes them suitable to manufacture three-dimensional macroporous scaffolds for bone tissue engineering. Finally, this review tackles the possibility of covalently grafting different osteoinductive agents to the scaffold surface that act as attracting signals for bone cells to promote the bone regeneration process.

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21

Nawaz, Qaisar, Muhammad Atiq Ur Rehman, Judith A. Roether, Liu Yufei, Alina Grünewald, Rainer Detsch, and Aldo R. Boccaccini. "Bioactive glass based scaffolds incorporating gelatin/manganese doped mesoporous bioactive glass nanoparticle coating." Ceramics International 45, no. 12 (August 2019): 14608–13. http://dx.doi.org/10.1016/j.ceramint.2019.04.179.

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22

Boccardi, Elena, Liliana Liverani, and Aldo R. Boccaccini. "Bioactive behavior of mesoporous silica particle (MCM‐41) coated bioactive glass‐based scaffolds." International Journal of Applied Ceramic Technology 16, no. 5 (April 16, 2019): 1753–61. http://dx.doi.org/10.1111/ijac.13245.

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23

Bari, Alessandra, Giulia Molino, Sonia Fiorilli, and Chiara Vitale-Brovarone. "Novel multifunctional strontium-copper co-substituted mesoporous bioactive particles." Materials Letters 223 (July 2018): 37–40. http://dx.doi.org/10.1016/j.matlet.2018.04.006.

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24

Lalzawmliana, V., Akrity Anand, Mangal Roy, Biswanath Kundu, and Samit Kumar Nandi. "Mesoporous bioactive glasses for bone healing and biomolecules delivery." Materials Science and Engineering: C 106 (January 2020): 110180. http://dx.doi.org/10.1016/j.msec.2019.110180.

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25

Yun, Hui-suk, Sang-hyun Kim, Soyoung Lee, and In-hyuck Song. "Synthesis of high surface area mesoporous bioactive glass nanospheres." Materials Letters 64, no. 16 (August 2010): 1850–53. http://dx.doi.org/10.1016/j.matlet.2010.04.053.

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26

Sun, Jin, Yongsheng Li, Liang Li, Wenru Zhao, Lei Li, Jianhua Gao, Meiling Ruan, and Jianlin Shi. "Functionalization and bioactivity in vitro of mesoporous bioactive glasses." Journal of Non-Crystalline Solids 354, no. 32 (August 2008): 3799–805. http://dx.doi.org/10.1016/j.jnoncrysol.2008.05.001.

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27

Xiao, Jian, Qianghua Wei, Jinhong Xue, Zhicong Liu, Zhen Li, Zifa Zhou, Fu Chen, and Fulai Zhao. "Mesoporous bioactive glass/bacterial cellulose composite scaffolds for bone support materials." Colloids and Surfaces A: Physicochemical and Engineering Aspects 642 (June 2022): 128693. http://dx.doi.org/10.1016/j.colsurfa.2022.128693.

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28

Guduric, Vera, Niall Belton, Richard Frank Richter, Anne Bernhardt, Janina Spangenberg, Chengtie Wu, Anja Lode, and Michael Gelinsky. "Tailorable Zinc-Substituted Mesoporous Bioactive Glass/Alginate-Methylcellulose Composite Bioinks." Materials 14, no. 5 (March 5, 2021): 1225. http://dx.doi.org/10.3390/ma14051225.

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Bioactive glasses have been used for bone regeneration applications thanks to their excellent osteoconductivity, an osteostimulatory effect, and high degradation rate, releasing biologically active ions. Besides these properties, mesoporous bioactive glasses (MBG) are specific for their highly ordered mesoporous channel structure and high specific surface area, making them suitable for drug and growth factor delivery. In the present study, calcium (Ca) (15 mol%) in MBG was partially and fully substituted with zinc (Zn), known for its osteogenic and antimicrobial properties. Different MBG were synthesized, containing 0, 5, 10, or 15 mol% of Zn. Up to 7 wt.% of Zn-containing MBG could be mixed into an alginate-methylcellulose blend (algMC) while maintaining rheological properties suitable for 3D printing of scaffolds with sufficient shape fidelity. The suitability of these composites for bioprinting applications has been demonstrated with immortalized human mesenchymal stem cells. Uptake of Ca and phosphorus (P) (phosphate) ions by composite scaffolds was observed, while the released concentration of Zn2+ corresponded to the initial amount of this ion in prepared glasses, suggesting that it can be controlled at the MBG synthesis step. The study introduces a tailorable bioprintable material system suitable for bone tissue engineering applications.

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Muhammad Ikram, Shabbir Hussain, and Mohsin Javed. "Nature and Therapeutic Potential of Silica-based Mesoporous Bioactive Glass." Scientific Inquiry and Review 3, no. 2 (June 5, 2019): 17–26. http://dx.doi.org/10.32350/sir.32.03.

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Bioactive materials have received much consideration in the last couple of years because of their astounding properties in various fields. Bioactive Glasses (BGs) are utilized as part of biomedical applications, such as antibacterial materials. BGs can be delivered by means of dissolve extinguishing strategy or sol-gel technique. Bactericidal silver-doped sol-gel inferred mesoporous silica-based bioactive glasses were accounted for the first time in 2000, having the synthesis 76SiO2-19CaO-2P2O5-3Ag2O (wt%) and a mean pore width of 28 nm. Bioactive glasses doped with metallic elements such as silver, copper, zinc, cerium and gallium are the focus of this audit in which SiO2, SiO2-CaO and SiO2-CaO-P2O5 frameworks are incorporated as the parent glass creations. Run of the mill uses of mesoporous BGs doped with antibacterial particles incorporate bone tissue recovery, multifunctional earthenware coatings for orthopedic gadgets and orbital inserts, scaffolds with upgraded angiogenesis potential, osteostimulation and antibacterial properties for the treatment of various bone imperfections and also in wound recuperating.

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Grela, Agnieszka, Joanna Kuc, and Tomasz Bajda. "A Review on the Application of Zeolites and Mesoporous Silica Materials in the Removal of Non-Steroidal Anti-Inflammatory Drugs and Antibiotics from Water." Materials 14, no. 17 (September 1, 2021): 4994. http://dx.doi.org/10.3390/ma14174994.

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Zeolites and mesoporous silica materials are effective adsorbents that can be useful for the removal of various pharmaceuticals including non-steroidal anti-inflammatory drugs and antibiotics from low-quality water. This paper summarizes the properties and basic characteristics of zeolites and mesoporous silica materials and reviews the recent studies on the efficacy of the adsorption of selected non-steroidal medicinal products and antibiotics by these adsorbents to assess the potential opportunities and challenges of using them in water treatment. It was found that the adsorption capacity of sorbents with high silica content is related to their surface hydrophobicity (hydrophilicity) and structural features, such as micropore volume and pore size, as well as the properties of the studied medicinal products. This review can be of help to scientists to develop an effective strategy for reducing the amount of these two groups of pharmaceuticals in wastewater.

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Izquierdo-Barba, Isabel, Miguel Manzano, Montserrat Colilla, and Maria Vallet-Regí. "Silica-Based Ordered Mesoporous Materials for Biomedical Applications." Key Engineering Materials 377 (March 2008): 133–50. http://dx.doi.org/10.4028/www.scientific.net/kem.377.133.

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Much research effort has been committed to the development of bioceramics that promote bone tissue regeneration and this is still one of the greatest challenges for the scientific community. In this sense, silica-based ordered mesoporous materials constitute a new generation of bioceramics that combine the intrinsic properties of bioceramics, such as bioactive behavior, together with the capability to host and controlled release biologically active molecules that promote new bone formation, i.e. drug delivery systems. In this chapter, the recent advances aimed at tailoring ordered mesoporous materials for biomedical applications will be tackled and critically discussed.

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Hooshmand, Sara, Sahar Mollazadeh, Negar Akrami, Mehrnoosh Ghanad, Ahmed El-Fiqi, Francesco Baino, Simin Nazarnezhad, and Saeid Kargozar. "Mesoporous Silica Nanoparticles and Mesoporous Bioactive Glasses for Wound Management: From Skin Regeneration to Cancer Therapy." Materials 14, no. 12 (June 17, 2021): 3337. http://dx.doi.org/10.3390/ma14123337.

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Exploring new therapies for managing skin wounds is under progress and, in this regard, mesoporous silica nanoparticles (MSNs) and mesoporous bioactive glasses (MBGs) offer great opportunities in treating acute, chronic, and malignant wounds. In general, therapeutic effectiveness of both MSNs and MBGs in different formulations (fine powder, fibers, composites etc.) has been proved over all the four stages of normal wound healing including hemostasis, inflammation, proliferation, and remodeling. The main merits of these porous substances can be summarized as their excellent biocompatibility and the ability of loading and delivering a wide range of both hydrophobic and hydrophilic bioactive molecules and chemicals. In addition, doping with inorganic elements (e.g., Cu, Ga, and Ta) into MSNs and MBGs structure is a feasible and practical approach to prepare customized materials for improved skin regeneration. Nowadays, MSNs and MBGs could be utilized in the concept of targeted therapy of skin malignancies (e.g., melanoma) by grafting of specific ligands. Since potential effects of various parameters including the chemical composition, particle size/morphology, textural properties, and surface chemistry should be comprehensively determined via cellular in vitro and in vivo assays, it seems still too early to draw a conclusion on ultimate efficacy of MSNs and MBGs in skin regeneration. In this regard, there are some concerns over the final fate of MSNs and MBGs in the wound site plus optimal dosages for achieving the best outcomes that deserve careful investigation in the future.

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Salinas, Antonio J., and Maria Vallet-Regí. "The Sol–Gel Production of Bioceramics." Key Engineering Materials 391 (October 2008): 141–58. http://dx.doi.org/10.4028/www.scientific.net/kem.391.141.

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Sol–gel synthesis is used for the fabrication of new materials with technological applications including ceramics for implants manufacturing, usually termed bioceramics. Many bioactive and resorbable bioceramics, that is, calcium phosphates, glasses and glass–ceramics, have been improved by using the sol–gel synthesis. In addition, the soft thermal conditions of sol–gel methods made possible to synthesize more reactive materials than those synthesized by traditional methods. Moreover, new families of bioactive materials such as organic–inorganic hybrids and inorganic compounds with ordered mesostructure can be produced. In hybrid materials, the inorganic component ensures the bioactive response whereas the organic polymeric component allows modulating other properties of the resulting biomaterial such as mechanical properties, degradation, etc. On the other hand, the sol–gel processes also allow the synthesis of silica ordered mesoporous materials, which are bioactive and exhibit – as an added value – a possible application as matrices for the controlled release of biologically active molecules (drugs, peptides, hormones, etc.). Finally, by combining the bioactive glasses composition with synthesis strategies of mesoporous materials, template glasses with ordered mesoporosity can be obtained. In this chapter, the advances that sol–gel technology has brought to the silica-based bioactive bioceramics are presented.

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Shih, Shao-Ju, Yu-Jen Chou, and Leon Valentino Posma Panjaitan. "Synthesis and characterization of spray pyrolyzed mesoporous bioactive glass." Ceramics International 39, no. 8 (December 2013): 8773–79. http://dx.doi.org/10.1016/j.ceramint.2013.04.064.

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Kumar, Alesh, Somesh Banrjee, Partha Roy, Huaizhong Xu, and C. R. Mariappan. "Osteogenic commitment of strontium nanoparticles doped mesoporous bioactive glass-ceramics." Materials Science and Engineering: B 286 (December 2022): 116068. http://dx.doi.org/10.1016/j.mseb.2022.116068.

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Kaya, Seray, Mark Cresswell, and Aldo R. Boccaccini. "Mesoporous silica-based bioactive glasses for antibiotic-free antibacterial applications." Materials Science and Engineering: C 83 (February 2018): 99–107. http://dx.doi.org/10.1016/j.msec.2017.11.003.

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Min, Zhu, Wang Huixue, Zhang Yujie, Ji Lixin, Huang Hai, and Zhu Yufang. "Synthesis of monodispersed mesoporous bioactive glass nanospheres for bone repair." Materials Letters 171 (May 2016): 259–62. http://dx.doi.org/10.1016/j.matlet.2016.01.156.

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Shih, C. J., H. T. Chen, L. F. Huang, P. S. Lu, H. F. Chang, and I. L. Chang. "Synthesis and in vitro bioactivity of mesoporous bioactive glass scaffolds." Materials Science and Engineering: C 30, no. 5 (June 2010): 657–63. http://dx.doi.org/10.1016/j.msec.2010.02.006.

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Zhang, Yufeng, Lingfei Wei, Jiang Chang, Richard J. Miron, Bin Shi, Siqi Yi, and Chengtie Wu. "Strontium-incorporated mesoporous bioactive glass scaffolds stimulating in vitro proliferation and differentiation of bone marrow stromal cells and in vivo regeneration of osteoporotic bone defects." Journal of Materials Chemistry B 1, no. 41 (2013): 5711–22. http://dx.doi.org/10.1039/c3tb21047b.

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Mo, Yunfei, Fujian Zhao, Zefeng Lin, Xiaodong Cao, Dafu Chen, and Xiaofeng Chen. "Local delivery of naringin in beta-cyclodextrin modified mesoporous bioactive glass promotes bone regeneration: from anti-inflammatory to synergistic osteogenesis and osteoclastogenesis." Biomaterials Science 10, no. 7 (2022): 1697–712. http://dx.doi.org/10.1039/d1bm01842f.

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The local delivery of naringin in beta-cyclodextrin modified mesoporous bioactive glass promotes bone regeneration via synergistic immunomodulation of osteogenesis and osteoclastogenesis by macrophages.

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Sanchez-Salcedo, Sandra, Gianluca Malavasi, Antonio Salinas, Gigliola Lusvardi, Luca Rigamonti, Ledi Menabue, and Maria Vallet-Regi. "Highly-Bioreactive Silica-Based Mesoporous Bioactive Glasses Enriched with Gallium(III)." Materials 11, no. 3 (March 2, 2018): 367. http://dx.doi.org/10.3390/ma11030367.

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Wawrzyńczak, Agata, Izabela Nowak, Natalia Woźniak, Jagoda Chudzińska, and Agnieszka Feliczak-Guzik. "Synthesis and Characterization of Hierarchical Zeolites Modified with Polysaccharides and Its Potential Role as a Platform for Drug Delivery." Pharmaceutics 15, no. 2 (February 5, 2023): 535. http://dx.doi.org/10.3390/pharmaceutics15020535.

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Hierarchical zeolites are aluminosilicates with a crystal structure, which next to the micropores possess secondary porosity in the range of mesopores and/or small macropores. Due to their ordered structure and additional secondary porosity, they have aroused great interest among scientists in recent years. Therefore, the present work concerns the synthesis and characterization of hierarchical zeolites with secondary mesoporosity, based on commercial zeolites such as MFI (ZSM-5), BEA (β) and FAU (Y), and modified with polysaccharides such as inulin, hyaluronic acid, and heparin. All materials were characterized by various analytical techniques and applied as a platform for delivery of selected drug molecules. On the basis of X-ray diffraction (presence of reflections in the 2θ angle range of 1.5–2.5°) and low-temperature nitrogen sorption isotherms (mixture of isotherms of I and IV type) additional secondary porosity was found in the mesopore range. Additional tests were also conducted to determine the possibility of loading selected molecules with biological activity into the aforementioned materials and then releasing them in the therapeutic process. Molecules with different therapeutic options were selected for testing, namely ibuprofen, curcumin, and ferulic acid with anti-inflammatory, potentially anticancer, antioxidant, and skin discoloration activities, respectively. Preliminary studies have confirmed the possibility of using hierarchical zeolites as potential carriers for bioactive molecules, as the loading percentage of active substances ranged from 39–79% and cumulative release for ibuprofen reached almost 100 % after 8 h of testing.

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Barczak, Mariusz. "Amine-modified mesoporous silicas: Morphology-controlled synthesis toward efficient removal of pharmaceuticals." Microporous and Mesoporous Materials 278 (April 2019): 354–65. http://dx.doi.org/10.1016/j.micromeso.2019.01.012.

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Barczak, Mariusz, Ryszard Dobrowolski, Piotr Borowski, and Dimitrios A. Giannakoudakis. "Pyridine-, thiol- and amine-functionalized mesoporous silicas for adsorptive removal of pharmaceuticals." Microporous and Mesoporous Materials 299 (June 2020): 110132. http://dx.doi.org/10.1016/j.micromeso.2020.110132.

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Liu, Wentao, Xin Wang, Xiaohan Gao, Xiaofeng Chen, Xinghua Yu, Hongsu Wang, and Xuming Deng. "Biotemplated multichannel mesoporous bioactive glass microtubes as a drug carrier." Ceramics International 39, no. 7 (September 2013): 8521–26. http://dx.doi.org/10.1016/j.ceramint.2013.03.034.

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Wang, Yudong, Tianshun Liao, Miao Shi, Cong Liu, and Xiaofeng Chen. "Facile synthesis and in vitro bioactivity of radial mesoporous bioactive glasses." Materials Letters 206 (November 2017): 205–9. http://dx.doi.org/10.1016/j.matlet.2017.07.021.

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Zhang, Ying, Xiang Wang, Yanli Su, Dongya Chen, and Wenxing Zhong. "A doxorubicin delivery system: Samarium/mesoporous bioactive glass/alginate composite microspheres." Materials Science and Engineering: C 67 (October 2016): 205–13. http://dx.doi.org/10.1016/j.msec.2016.05.019.

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Shruti, Shruti, Antonio J. Salinas, Erika Ferrari, Gianluca Malavasi, Gigliola Lusvardi, Antonio L. Doadrio, Ledi Menabue, and M. Vallet-Regi. "Curcumin release from cerium, gallium and zinc containing mesoporous bioactive glasses." Microporous and Mesoporous Materials 180 (November 2013): 92–101. http://dx.doi.org/10.1016/j.micromeso.2013.06.014.

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Yan, Penghua, Jinqing Wang, Junfei Ou, Zhangpeng Li, Ziqiang Lei, and Shengrong Yang. "Synthesis and characterization of three-dimensional ordered mesoporous–macroporous bioactive glass." Materials Letters 64, no. 22 (November 2010): 2544–47. http://dx.doi.org/10.1016/j.matlet.2010.08.033.

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Zhu, Hailin, Chao Hu, Fangfang Zhang, Xinxing Feng, Jiuming Li, Tao Liu, Jianyong Chen, and Jianchun Zhang. "Preparation and antibacterial property of silver-containing mesoporous 58S bioactive glass." Materials Science and Engineering: C 42 (September 2014): 22–30. http://dx.doi.org/10.1016/j.msec.2014.05.004.

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