Journal articles: 'Mesoporous bioactive glasse'

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Migneco, Carla, Elisa Fiume, Enrica Verné, and Francesco Baino. "A Guided Walk through the World of Mesoporous Bioactive Glasses (MBGs): Fundamentals, Processing, and Applications." Nanomaterials 10, no. 12 (December 21, 2020): 2571. http://dx.doi.org/10.3390/nano10122571.

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Bioactive glasses (BGs) are traditionally known to be able to bond to living bone and stimulate bone regeneration. The production of such materials in a mesoporous form allowed scientists to dramatically expand the versatility of oxide-based glass systems as well as their applications in biomedicine. These nanostructured materials, called mesoporous bioactive glasses (MBGs), not only exhibit an ultrafast mineralization rate but can be used as vehicles for the sustained delivery of drugs, which are hosted inside the mesopores, and therapeutic ions, which are released during material dissolution in contact with biological fluids. This review paper summarizes the main strategies for the preparation of MBGs, as well as their properties and applications in the biomedical field, with an emphasis on the methodological aspects and the promise of hierarchical systems with multiscale porosity.

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Zhao, Yu Feng, and Jan Ma. "Mesoporous Bioactive Glasses: Synthesis, Characterization and In Vitro Bioactivity." Journal of Biomimetics, Biomaterials and Tissue Engineering 1 (July 2008): 37–47. http://dx.doi.org/10.4028/www.scientific.net/jbbte.1.37.

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In this work, two systems of mesoporous bioactive glasses (MBGs) with a series of different SiO2:CaO:P2O5 ratios were derived via a sol-gel method involving the usage of block copolymers Pluronic F127 and P123 as templates, respectively. A two-dimensional hexagonal (P6mm) mesoporous structure was obtained in the two systems with a SiO2:CaO:P2O5 ratio of 80:16:4. With the decrease of the SiO2 content, the porous structure of MBGs became less regular, and the BET surface area and the pore volume were also decreased. Mesoporous bioactive glasses from the template F127 displayed a higher degree of bioactivity than those from the template P123, as a result of the existence of more defects on the walls of the mesopores.

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Phetnin, Ratiya, and Sirirat Tubsungnoen Rattanachan. "Bio-Hybrid Composite Scaffold from Silk Fibroin/Chitosan/Mesoporous Bioactive Glass Microspheres for Tissue Engineering Applications." Advanced Materials Research 1131 (December 2015): 79–83. http://dx.doi.org/10.4028/www.scientific.net/amr.1131.79.

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This research aims to fabricate the novel bio-hybrid composite scaffold from mesoporous bioactive glasses/silk fibroin/chitosan (MBGs/SF/CS) for use in tissue engineering applications. MBGs/SF/CS composite scaffolds were successfully fabricated using freezing and lyophilization process. Two types of mesoporous bioactive glasses which were irregular and spherical shape were dispersed in the silk fibroin/chitosan based scaffolds in order to improve the mechanical strength and bioactivity. SEM observation showed the interconnected pores with pore size from 100 to 300 µm. XRD and FTIR exhibited the present of silk fibroin, chitosan, and MBGs in composite scaffolds. The incorporation of MBGs in SF/CS scaffolds significantly increased the compressive strength of scaffolds. The composite scaffolds were immersed in the simulated body fluid (SBF) for in vitro bioactivity test. The in vitro bioactivity results indicated that the MBGs/SF/CS induced hydroxycarbonate apatite (HCA) formation while there was no change for SF/CS scaffolds. Furthermore, mesoporous bioactive glass with micro-spherical particles (MBGMs) which easily dispersed in SF/CS solution during the fabrication of scaffolds as compared to mesoporous bioactive glass with irregular shape (MBGs). The results showed that MBGs/SF/CS composite scaffolds could be useful composite scaffolds for tissue engineering applications.

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Liu, Jiawei, Guo Du, Hongda Yu, Xueyin Zhang, and Tiehong Chen. "Synthesis of Hierarchically Porous Bioactive Glass and Its Mineralization Activity." Molecules 28, no. 5 (February 27, 2023): 2224. http://dx.doi.org/10.3390/molecules28052224.

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Mesoporous bioactive glass is a promising biomaterial for bone tissue engineering due to its good biocompatibility and bioactivity. In this work, we synthesized a hierarchically porous bioactive glass (HPBG) using polyelectrolyte-surfactant mesomorphous complex as template. Through the interaction with silicate oligomers, calcium and phosphorus sources were successfully introduced into the synthesis of hierarchically porous silica, and HPBG with ordered mesoporous and nanoporous structures was obtained. The morphology, pore structure and particle size of HPBG can be controlled by adding block copolymer as co-template or adjusting the synthesis parameters. The ability to induce hydroxyapatite deposition in simulated body fluids (SBF) demonstrated the good in vitro bioactivity of HPBG. Overall, this work provides a general method for the synthesis of hierarchically porous bioactive glasses.

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Muhammad Ikram, Shabbir Hussain, and Mohsin Javed. "Nature and Therapeutic Potential of Silica-based Mesoporous Bioactive Glass." Scientific Inquiry and Review 3, no. 2 (June 5, 2019): 17–26. http://dx.doi.org/10.32350/sir.32.03.

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Bioactive materials have received much consideration in the last couple of years because of their astounding properties in various fields. Bioactive Glasses (BGs) are utilized as part of biomedical applications, such as antibacterial materials. BGs can be delivered by means of dissolve extinguishing strategy or sol-gel technique. Bactericidal silver-doped sol-gel inferred mesoporous silica-based bioactive glasses were accounted for the first time in 2000, having the synthesis 76SiO2-19CaO-2P2O5-3Ag2O (wt%) and a mean pore width of 28 nm. Bioactive glasses doped with metallic elements such as silver, copper, zinc, cerium and gallium are the focus of this audit in which SiO2, SiO2-CaO and SiO2-CaO-P2O5 frameworks are incorporated as the parent glass creations. Run of the mill uses of mesoporous BGs doped with antibacterial particles incorporate bone tissue recovery, multifunctional earthenware coatings for orthopedic gadgets and orbital inserts, scaffolds with upgraded angiogenesis potential, osteostimulation and antibacterial properties for the treatment of various bone imperfections and also in wound recuperating.

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Kermani, Farzad, Hossein Sadidi, Ali Ahmadabadi, Seyed Javad Hoseini, Seyed Hasan Tavousi, Alireza Rezapanah, Simin Nazarnezhad, Seyede Atefe Hosseini, Sahar Mollazadeh, and Saeid Kargozar. "Modified Sol–Gel Synthesis of Mesoporous Borate Bioactive Glasses for Potential Use in Wound Healing." Bioengineering 9, no. 9 (September 5, 2022): 442. http://dx.doi.org/10.3390/bioengineering9090442.

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In this study, we successfully utilized nitrate precursors for the synthesis of silver (Ag)-doped borate-based mesoporous bioactive glass (MBGs) based on the 1393B3 glass formulation in the presence of a polymeric substrate (polyvinyl alcohol (PVA)) as a stabilizer of boric acid. The X-ray diffraction (XRD) analysis confirmed the glassy state of all the MBGs. The incorporation of 7.5 mol% Ag into the glass composition led to a decrease in the glass transition temperature (Tg). Improvements in the particle size, zeta potential, surface roughness, and surface area values were observed in the Ag-doped MBGs. The MBGs (1 mg/mL) had no adverse effect on the viability of fibroblasts. In addition, Ag-doped MBGs exhibited potent antibacterial activity against gram-positive and gram-negative species. In summary, a modified sol–gel method was confirmed for producing the Ag-doped 1393B3 glasses, and the primary in vitro outcomes hold promise for conducting in vivo studies for managing burns.

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Son, Sung-Ae, Dong-Hyun Kim, Kyung-Hyeon Yoo, Seog-Young Yoon, and Yong-Il Kim. "Mesoporous Bioactive Glass Combined with Graphene Oxide Quantum Dot as a New Material for a New Treatment Option for Dentin Hypersensitivity." Nanomaterials 10, no. 4 (March 27, 2020): 621. http://dx.doi.org/10.3390/nano10040621.

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Dentin hypersensitivity is one of the most common clinical conditions usually associated with exposed dentinal tubules. The purpose of this study was to identify the potential of a graphene oxide quantum dot coating for mesoporous bioactive glass nanoparticles as a new material for the treatment of dentin hypersensitivity by investigating its mineralization activity and dentinal tubules sealing. Mesoporous bioactive glass nanoparticle was fabricated by modified sol-gel synthesis. X-ray diffraction was performed to characterize the synthesized nanoparticle Fourier transform infra-red spectroscopy investigated the functionalized surfaces. The distribution of the specific surface area and the pore size was measure by Pore size analysis. The morphology of sample was observed by Field Emission Scanning Electron Microscope (FESEM) and Field Emission Transmission Electron Microscope (FETEM). After disk-shaped specimens of mesoporous bioactive glass nanoparticles and graphene oxide quantum dot coated mesoporous bioactive glass nanoparticles (n = 3) were soaked in the simulated body fluid for 0, 1, 5, 10,and 30 days, the amount of ions released was observed to confirm the ionic elution for mineralization. Sensitive tooth model discs (n = 20) were applied with two samples and evaluated the dentinal tubule sealing ability. The spherical mesoporous bioactive glass nanoparticles and graphene oxide quantum dot coated mesoporous bioactive glass nanoparticles with a diameter of about 500 nm were identified through FESEM and FETEM. The ion release capacity of both samples appeared to be very similar. The amount of ion released and in vitro mineralization tests confirmed that graphene oxide quantum dot coating of mesoporous bioactive glass nanoparticles did not inhibit the release of calcium, silicon and phosphate ions, but rather that graphene oxide quantum dot promoted hydroxyapatite formation. In the FESEM image of the sensitive tooth disc surface, it was observed that graphene oxide quantum dot coated mesoporous bioactive glass nanoparticles sealed tightly the dentinal tubules. The graphene oxide quantum dot coating of mesoporous bioactive glass nanoparticles not only showed the excellent dentinal sealing ability but also rapidly promoted mineralization while minimizing the size increase by coating the mesoporous bioactive glass nanoparticles.

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Salinas, Antonio J., and Maria Vallet-Regí. "The Sol–Gel Production of Bioceramics." Key Engineering Materials 391 (October 2008): 141–58. http://dx.doi.org/10.4028/www.scientific.net/kem.391.141.

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Sol–gel synthesis is used for the fabrication of new materials with technological applications including ceramics for implants manufacturing, usually termed bioceramics. Many bioactive and resorbable bioceramics, that is, calcium phosphates, glasses and glass–ceramics, have been improved by using the sol–gel synthesis. In addition, the soft thermal conditions of sol–gel methods made possible to synthesize more reactive materials than those synthesized by traditional methods. Moreover, new families of bioactive materials such as organic–inorganic hybrids and inorganic compounds with ordered mesostructure can be produced. In hybrid materials, the inorganic component ensures the bioactive response whereas the organic polymeric component allows modulating other properties of the resulting biomaterial such as mechanical properties, degradation, etc. On the other hand, the sol–gel processes also allow the synthesis of silica ordered mesoporous materials, which are bioactive and exhibit – as an added value – a possible application as matrices for the controlled release of biologically active molecules (drugs, peptides, hormones, etc.). Finally, by combining the bioactive glasses composition with synthesis strategies of mesoporous materials, template glasses with ordered mesoporosity can be obtained. In this chapter, the advances that sol–gel technology has brought to the silica-based bioactive bioceramics are presented.

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Schmitz, Seray, Ana M. Beltrán, Mark Cresswell, and Aldo R. Boccaccini. "A Structural Comparison of Ordered and Non-Ordered Ion Doped Silicate Bioactive Glasses." Materials 13, no. 4 (February 22, 2020): 992. http://dx.doi.org/10.3390/ma13040992.

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One of the key benefits of sol-gel-derived glasses is the presence of a mesoporous structure and the resulting increase in surface area. This enhancement in textural properties has a significant effect on the physicochemical properties of the materials. In this context the aim of this study was to investigate how sol-gel synthesis parameters can influence the textural and structural properties of mesoporous silicate glasses. We report the synthesis and characterization of metal ion doped sol-gel derived glasses with different dopants in the presence or absence of a surfactant (Pluronic P123) used as structure-directing templating agent. Characterization was done by several methods. Using a structure directing agent led to larger surface areas and highly ordered mesoporous structures. The chemical structure of the non-ordered glasses was modified to a larger extent than the one of the ordered glasses due to increased incorporation of dopant ions into the glass network. The results will help to further understand how the properties of sol-gel glasses can be controlled by incorporation of metal dopants, in conjunction with control over the textural properties, and will be important to optimize the properties of sol-gel glasses for specific applications, e.g., drug delivery, bone regeneration, wound healing, and antibacterial materials.

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Salinas, Antonio J., and Pedro Esbrit. "Mesoporous Bioglasses Enriched with Bioactive Agents for Bone Repair, with a Special Highlight of María Vallet-Regí’s Contribution." Pharmaceutics 14, no. 1 (January 15, 2022): 202. http://dx.doi.org/10.3390/pharmaceutics14010202.

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Throughout her impressive scientific career, Prof. María Vallet-Regí opened various research lines aimed at designing new bioceramics, including mesoporous bioactive glasses for bone tissue engineering applications. These bioactive glasses can be considered a spin-off of silica mesoporous materials because they are designed with a similar technical approach. Mesoporous glasses in addition to SiO2 contain significant amounts of other oxides, particularly CaO and P2O5 and therefore, they exhibit quite different properties and clinical applications than mesoporous silica compounds. Both materials exhibit ordered mesoporous structures with a very narrow pore size distribution that are achieved by using surfactants during their synthesis. The characteristics of mesoporous glasses made them suitable to be enriched with various osteogenic agents, namely inorganic ions and biopeptides as well as mesenchymal cells. In the present review, we summarize the evolution of mesoporous bioactive glasses research for bone repair, with a special highlight on the impact of Prof. María Vallet-Regí´s contribution to the field.

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Boonyang, U., F. Li, and A. Stein. "Hierarchical Structures and Shaped Particles of Bioactive Glass and ItsIn VitroBioactivity." Journal of Nanomaterials 2013 (2013): 1–6. http://dx.doi.org/10.1155/2013/681391.

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In this study, bioactive glass particles with controllable structure and porosity were prepared using dual-templating methods. Block copolymers used as one template component produced mesopores in the calcined samples. Polymer colloidal crystals as the other template component yielded either three-dimensionally ordered macroporous (3DOM) products or shaped bioactive glass nanoparticles. Thein vitrobioactivity of these bioactive glasses was studied by soaking the samples in simulated body fluid (SBF) at body temperature (37°C) for varying lengths of time and monitoring the formation of bone-like apatite on the surface of the bioactive glass. A considerable bioactivity was found that all of bioactive glass samples have the ability to induce the formation of an apatite layer on its surface when in contact with SBF. The development of bone-like apatite is faster for 3DOM bioactive glasses than for nanoparticles.

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Philippart, Anahí, Elena Boccardi, Lucia Pontiroli, Ana Maria Beltrán, Alexandra Inayat, Chiara Vitale-Brovarone, Wilhelm Schwieger, Erdmann Spiecker, and Aldo Roberto Boccaccini. "Development of Novel Mesoporous Silica-Based Bioactive Glass Scaffolds with Drug Delivery Capabilities." Advances in Science and Technology 96 (October 2014): 54–60. http://dx.doi.org/10.4028/www.scientific.net/ast.96.54.

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Novel silica-based bioactive glasses were successfully prepared by the sol-gel method. The optimized glass composition for fabrication of the scaffolds was (in mol.%) 60% SiO2 – 30% CaO - 5% Na2O - 5% P2O5 (60S30C5N5P). This composition was confirmed to develop a thick hydroxycarbonate apatite (HCA) layer in Simulated Body Fluid (SBF) after 7 days, as revealed by Fourier Transform Infrared Spectroscopy (FTIR), indicating the bioactive character of the scaffolds. The mesoporous nature of the glass structure allows the load of tetracycline and a sustained release of the drug in PBS during 7 days was measured.

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Wu, Chengtie, and Jiang Chang. "Mesoporous bioactive glasses: structure characteristics, drug/growth factor delivery and bone regeneration application." Interface Focus 2, no. 3 (March 21, 2012): 292–306. http://dx.doi.org/10.1098/rsfs.2011.0121.

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The impact of bone diseases and trauma in the whole world has increased significantly in the past decades. Bioactive glasses are regarded as an important bone regeneration material owing to their generally excellent osteoconductivity and osteostimulativity. A new class of bioactive glass, referred to as mesoporous bioglass (MBG), was developed 7 years ago, which possess a highly ordered mesoporous channel structure and a highly specific surface area. The study of MBG for drug/growth factor delivery and bone tissue engineering has grown significantly in the past several years. In this article, we review the recent advances of MBG materials, including the preparation of different forms of MBG, composition–structure relationship, efficient drug/growth factor delivery and bone tissue engineering application. By summarizing our recent research, the interaction of MBG scaffolds with bone-forming cells, the effect of drug/growth factor delivery on proliferation and differentiation of tissue cells and the in vivo osteogenesis of MBG scaffolds are highlighted. The advantages and limitations of MBG for drug delivery and bone tissue engineering have been compared with microsize bioactive glasses and nanosize bioactive glasses. The future perspective of MBG is discussed for bone regeneration application by combining drug delivery with bone tissue engineering and investigating the in vivo osteogenesis mechanism in large animal models.

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Kargozar, Saeid, Francesco Baino, Sara Banijamali, and Masoud Mozafari. "Synthesis and physico-chemical characterization of fluoride (F)- and silver (Ag)-substituted sol-gel mesoporous bioactive glasses." Biomedical Glasses 5, no. 1 (January 1, 2019): 185–92. http://dx.doi.org/10.1515/bglass-2019-0015.

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Abstract Synthesis and use of novel compositions of bioactive glasses (BGs) for hard tissue engineering are of important significance in the biomedical field. In this study, we successfully synthesized a series of 58S-based BGs containing fluoride (F−) and silver (Ag+) ions through a sol-gel method for possible use in bone/dental regeneration and antibacterial strategies. Characterizations of samples were performed by using thermal analyses (thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC)), X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), textural analysis (N2 adsorption-desorption), and morphological observations by transmission electron microscopy (TEM) and scanning electron microscopy (SEM). The obtained data revealed that the fabricated BGs are in a glassy state before incubation in the Kokubo’s simulated body fluid (SBF), and an apatite-like layer is formed on their surface after 7 days of immersion in SBF. The size of the glass particles was in the nano-range (about 100 nm or below), and their pore size was in the mesoporous range (15-25 nm). These early results suggest that the F- and Ag-doped glasses show promise as multifunctional bioactive materials for bone/dental tissue engineering.

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Kermani, Farzad, Simin Nazarnezhad, Zahra Mollaei, Sahar Mollazadeh, Alireza Ebrahimzadeh-Bideskan, Vahid Reza Askari, Reza Kazemi Oskuee, et al. "Zinc- and Copper-Doped Mesoporous Borate Bioactive Glasses: Promising Additives for Potential Use in Skin Wound Healing Applications." International Journal of Molecular Sciences 24, no. 2 (January 9, 2023): 1304. http://dx.doi.org/10.3390/ijms24021304.

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In this study, zinc (Zn)- and copper (Cu)-doped 13-93B3 borate mesoporous bioactive glasses (MBGs) were successfully synthesized using nitrate precursors in the presence of Pluronic P123. We benefited from computational approaches for predicting and confirming the experimental findings. The changes in the dynamic surface tension (SFT) of simulated body fluid (SBF) were investigated using the Du Noüy ring method to shed light on the mineralization process of hydroxyapatite (HAp) on the glass surface. The obtained MBGs were in a glassy state before incubation in SBF. The formation of an apatite-like layer on the SBF-incubated borate glasses was investigated by X-ray diffraction (XRD) and scanning electron microscopy (SEM). The incorporation of Zn and Cu into the basic composition of 13-93B3 glass led to changes in the glass transition temperature (Tg) (773 to 556 °C), particle size (373 to 64 nm), zeta potential (−12 to −26 mV), and specific surface area (SBET) (54 to 123 m2/g). Based on the K-means algorithm and chi-square automatic interaction detection (CHAID) tree, we found that the SFT of SBF is an important factor for the prediction and confirmation of the HAp mineralization process on the glasses. Furthermore, we proposed a simple calculation, based on SFT variation, to quantify the bioactivity of MBGs. The doped and dopant-free borate MBGs could enhance the proliferation of mouse fibroblast L929 cells at a concentration of 0.5 mg/mL. These glasses also induced very low hemolysis (<5%), confirming good compatibility with red blood cells. The results of the antibacterial test revealed that all the samples could significantly decrease the viability of Pseudomonas aeruginosa. In summary, we showed that Cu-/Zn-doped borate MBGs can be fabricated using a cost-effective method and also show promise for wound healing/skin tissue engineering applications, as especially supported by the cell test with fibroblasts, good compatibility with blood, and antibacterial properties.

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Tuan, Ta Anh, Elena V. Guseva, Nguyen Anh Tien, Ha Tuan Anh, Bui Xuan Vuong, Le Hong Phuc, Nguyen Quan Hien, Bui Thi Hoa, and Nguyen Viet Long. "Hydrothermal assisted conventional sol-gel method for synthesis of bioactive glass 70S30Cы." Kondensirovannye sredy i mezhfaznye granitsy = Condensed Matter and Interphases 23, no. 4 (November 24, 2021): 585–93. http://dx.doi.org/10.17308/kcmf.2021.23/3678.

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Bioactive glasses (Bioglasses) are widely synthesized by the conventional sol-gel method consisting of two main steps for sol and gel formation. However, the conversion from sol to gel requires a long time (5–7 days). In this study, the hydrothermal system was used to quickly synthesize the bioactive glass by reducing the conversion time from sol to gel. The hydrothermal assisted conventional sol-gel method was applied for synthesis of the bioactive glass 70SiO2–30CaO (mol%) (noted as 70S30C). The synthetic glass was investigated by the physical-chemical techniques. The ‘‘in vitro’’ experiments in SBF (Simulated Body Fluid) solution was also performed to evaluate the bioactivity of synthetic material. The obtained results show that the bioactive glass 70S30C was successfully elaborated by using the hydrothermal assisted conventional sol-gelmethod. The consuming time was reduced compared to the conventional method. The physical-chemical characterization confirmed that the synthetic glass is amorphous material with mesoporous structure consisting of interconnected particles.The specific surface area, pore volume and average pore diameter of synthetic glass were 142.8 m2/g, 0.52 cm3/g, and 19.1 nm, respectively. Furthermore, synthetic bioactive glass exhibited interesting bioactivity when immersed in simulated body fluid (SBF) solution for 1 days and good biocompatibility when cultured in cellular media.

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Vallet-Regí, María, Isabel Izquierdo-Barba, and Montserrat Colilla. "Structure and functionalization of mesoporous bioceramics for bone tissue regeneration and local drug delivery." Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 370, no. 1963 (March 28, 2012): 1400–1421. http://dx.doi.org/10.1098/rsta.2011.0258.

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This review article describes the importance of structure and functionalization in the performance of mesoporous silica bioceramics for bone tissue regeneration and local drug delivery purposes. Herein, we summarize the pivotal features of mesoporous bioactive glasses, also known as ‘templated glasses’ (TGs), which present chemical compositions similar to those of conventional bioactive sol–gel glasses and the added value of an ordered mesopore arrangement. An in-depth study concerning the possibility of tailoring the structural and textural characteristics of TGs at the nanometric scale and their influence on bioactive behaviour is discussed. The highly ordered mesoporous arrangement of cavities allows these materials to confine drugs to be subsequently released, acting as drug delivery devices. The functionalization of mesoporous silica walls has been revealed as the cornerstone in the performance of these materials as controlled release systems. The synergy between the improved bioactive behaviour and local sustained drug release capability of mesostructured materials makes them suitable to manufacture three-dimensional macroporous scaffolds for bone tissue engineering. Finally, this review tackles the possibility of covalently grafting different osteoinductive agents to the scaffold surface that act as attracting signals for bone cells to promote the bone regeneration process.

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Gisbert-Garzarán, Miguel, and María Vallet-Regí. "Nanoparticles for Bio-Medical Applications." Nanomaterials 12, no. 7 (April 2, 2022): 1189. http://dx.doi.org/10.3390/nano12071189.

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The Special Issue of Nanomaterials “Nanoparticles for Biomedical Applications” highlights the use of different types of nanoparticles for biomedical applications, including magnetic nanoparticles, mesoporous carbon nanoparticles, mesoporous bioactive glass nanoparticles, and mesoporous silica nanoparticles [...]

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Pérez, Rebeca, Sandra Sanchez-Salcedo, Daniel Lozano, Clara Heras, Pedro Esbrit, María Vallet-Regí, and Antonio Salinas. "Osteogenic Effect of ZnO-Mesoporous Glasses Loaded with Osteostatin." Nanomaterials 8, no. 8 (August 4, 2018): 592. http://dx.doi.org/10.3390/nano8080592.

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Mesoporous Bioactive Glasses (MBGs) are a family of bioceramics widely investigated for their putative clinical use as scaffolds for bone regeneration. Their outstanding textural properties allow for high bioactivity when compared with other bioactive materials. Moreover, their great pore volumes allow these glasses to be loaded with a wide range of biomolecules to stimulate new bone formation. In this study, an MBG with a composition, in mol%, of 80% SiO2–15% CaO–5% P2O5 (Blank, BL) was compared with two analogous glasses containing 4% and 5% of ZnO (4ZN and 5ZN) before and after impregnation with osteostatin, a C-terminal peptide from a parathyroid hormone-related protein (PTHrP107-111). Zn2+ ions were included in the glass for their bone growth stimulator properties, whereas osteostatin was added for its osteogenic properties. Glasses were characterized, and their cytocompatibility investigated, in pre-osteoblastic MC3T3-E1 cell cultures. The simultaneous additions of osteostatin and Zn2+ ions provoked enhanced MC3T3-E1 cell viability and a higher differentiation capacity, compared with either raw BL or MBGs supplemented only with osteostatin or Zn2+. These in vitro results show that osteostatin enhances the osteogenic effect of Zn2+-enriched glasses, suggesting the potential of this combined approach in bone tissue engineering applications.

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Xiao, Jian, Qianghua Wei, Jinhong Xue, Zide Yang, Zhicheng Deng, and Fulai Zhao. "Preparation and In Vitro Bioactivity Study of a Novel Hollow Mesoporous Bioactive Glass Nanofiber Scaffold." Molecules 27, no. 22 (November 17, 2022): 7973. http://dx.doi.org/10.3390/molecules27227973.

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In this study, a novel three-dimensional hollow mesoporous bioactive glass nanofiber scaffold has been synthesized with a template-assisted sol-gel method using bacterial cellulose (BC) as a template and nonionic triblock copolymer (P123) as a pore-directing agent, ethyl orthosilicate (TEOS), calcium nitrate tetrahydrate (CN), and triethyl phosphate (TEP) as glass precursors. Scanning and transmission electron microscopies, X-ray diffraction, nitrogen adsorption-desorption, and nuclear magnetic resonance method were applied to characterize the morphology, crystal structure, and chemical structure of the mesoporous bioactive glass nanofiber scaffold. Furthermore, the in vitro bioactivity and biocompatibility were also explored. The obtained scaffold depicted nanofiber-like morphology and interconnected three-dimensional network structure that replicated the BC template. The scaffold showed a large specific surface area (230.0 cm2 g−1) and pore volume (0.2 m3 g−1). More importantly, the scaffold exhibited excellent apatite-forming ability and cellular biocompatibility. We believe that the hollow mesoporous bioactive glass nanofiber scaffold has great potential application in bone tissue regeneration.

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Gómez-Cerezo, N., I. Izquierdo-Barba, D. Arcos, and M. Vallet-Regí. "Tailoring the biological response of mesoporous bioactive materials." Journal of Materials Chemistry B 3, no. 18 (2015): 3810–19. http://dx.doi.org/10.1039/c5tb00268k.

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Vallet-Regi, M., and A. J. Salinas. "Mesoporous bioactive glasses for regenerative medicine." Materials Today Bio 11 (June 2021): 100121. http://dx.doi.org/10.1016/j.mtbio.2021.100121.

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Tallia, Francesca, Marta Gallo, Lucia Pontiroli, Francesco Baino, Sonia Fiorilli, Barbara Onida, Giovanni C. Anselmetti, Antonio Manca, and Chiara Vitale-Brovarone. "Zirconia-containing radiopaque mesoporous bioactive glasses." Materials Letters 130 (September 2014): 281–84. http://dx.doi.org/10.1016/j.matlet.2014.05.062.

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Dadkhah, Mehran, Lucia Pontiroli, Sonia Fiorilli, Antonio Manca, Francesca Tallia, Ion Tcacencu, and Chiara Vitale-Brovarone. "Preparation and characterisation of an innovative injectable calcium sulphate based bone cement for vertebroplasty application." Journal of Materials Chemistry B 5, no. 1 (2017): 102–15. http://dx.doi.org/10.1039/c6tb02139e.

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Li, Xian, Xiaofeng Chen, Guohou Miao, Hui Liu, Cong Mao, Guang Yuan, Qiming Liang, Xiongjun Shen, Chengyun Ning, and Xiaoling Fu. "Synthesis of radial mesoporous bioactive glass particles to deliver osteoactivin gene." J. Mater. Chem. B 2, no. 40 (2014): 7045–54. http://dx.doi.org/10.1039/c4tb00883a.

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Qin, Xiang, Rong Cao, Jingjing Zheng, Guojun Shi, Lijun Ji, Aiping Zhu, and Hang Yao. "A new strategy for synthesizing silver doped mesoporous bioactive glass fibers and their bioactivity, antibacterial activity and drug loading performance." RSC Advances 10, no. 73 (2020): 44835–40. http://dx.doi.org/10.1039/d0ra08656h.

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Boanini, Elisa, Silvia Panseri, Fabiola Arroyo, Monica Montesi, Katia Rubini, Anna Tampieri, Cristian Covarrubias, and Adriana Bigi. "Alendronate Functionalized Mesoporous Bioactive Glass Nanospheres." Materials 9, no. 3 (February 26, 2016): 135. http://dx.doi.org/10.3390/ma9030135.

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Kermani, Farzad, Sahar Mollazadeh Beidokhti, Francesco Baino, Zahra Gholamzadeh-Virany, Masoud Mozafari, and Saeid Kargozar. "Strontium- and Cobalt-Doped Multicomponent Mesoporous Bioactive Glasses (MBGs) for Potential Use in Bone Tissue Engineering Applications." Materials 13, no. 6 (March 16, 2020): 1348. http://dx.doi.org/10.3390/ma13061348.

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Mesoporous bioactive glasses (MBGs) offer suitable platforms for drug/ion delivery in tissue engineering strategies. The main goal of this study was to prepare strontium (Sr)- and cobalt (Co)-doped MBGs; strontium is currently used in the treatment of osteoporosis, and cobalt is known to exhibit pro-angiogenic effects. Sr- and Co-doped mesoporous glasses were synthesized for the first time in a multicomponent silicate system via the sol–gel method by using P123 as a structure-directing agent. The glassy state of the Sr- and Co-doped materials was confirmed by XRD before immersion in SBF, while an apatite-like layer was detected onto the surface of samples post-immersion. The textural characteristics of MBGs were confirmed by nitrogen adsorption/desorption measurements. In vitro experiments including MTT assay, Alizarin red staining, and cell attachment and migration showed the cytocompatibility of all the samples as well as their positive effects on osteoblast-like cell line MG-63. Early experiments with human umbilical vein endothelial cells also suggested the potential of these MBGs in the context of angiogenesis. In conclusion, the prepared materials were bioactive, showed the ability to improve osteoblast cell function in vitro and could be considered as valuable delivery vehicles for therapeutics, like Co2+ and Sr2+ ions.

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Zhang, Yufeng, Lingfei Wei, Jiang Chang, Richard J. Miron, Bin Shi, Siqi Yi, and Chengtie Wu. "Strontium-incorporated mesoporous bioactive glass scaffolds stimulating in vitro proliferation and differentiation of bone marrow stromal cells and in vivo regeneration of osteoporotic bone defects." Journal of Materials Chemistry B 1, no. 41 (2013): 5711–22. http://dx.doi.org/10.1039/c3tb21047b.

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Vallet-Regí, María, Montserrat Colilla, Isabel Izquierdo-Barba, Chiara Vitale-Brovarone, and Sonia Fiorilli. "Achievements in Mesoporous Bioactive Glasses for Biomedical Applications." Pharmaceutics 14, no. 12 (November 29, 2022): 2636. http://dx.doi.org/10.3390/pharmaceutics14122636.

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Nowadays, mesoporous bioactive glasses (MBGs) are envisaged as promising candidates in the field of bioceramics for bone tissue regeneration. This is ascribed to their singular chemical composition, structural and textural properties and easy-to-functionalize surface, giving rise to accelerated bioactive responses and capacity for local drug delivery. Since their discovery at the beginning of the 21st century, pioneering research efforts focused on the design and fabrication of MBGs with optimal compositional, textural and structural properties to elicit superior bioactive behavior. The current trends conceive MBGs as multitherapy systems for the treatment of bone-related pathologies, emphasizing the need of fine-tuning surface functionalization. Herein, we focus on the recent developments in MBGs for biomedical applications. First, the role of MBGs in the design and fabrication of three-dimensional scaffolds that fulfil the highly demanding requirements for bone tissue engineering is outlined. The different approaches for developing multifunctional MBGs are overviewed, including the incorporation of therapeutic ions in the glass composition and the surface functionalization with zwitterionic moieties to prevent bacterial adhesion. The bourgeoning scientific literature on MBGs as local delivery systems of diverse therapeutic cargoes (osteogenic/antiosteoporotic, angiogenic, antibacterial, anti-inflammatory and antitumor agents) is addressed. Finally, the current challenges and future directions for the clinical translation of MBGs are discussed.

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Pourshahrestani, Sara, Nahrizul Adib Kadri, Ehsan Zeimaran, and Mark R. Towler. "Well-ordered mesoporous silica and bioactive glasses: promise for improved hemostasis." Biomaterials Science 7, no. 1 (2019): 31–50. http://dx.doi.org/10.1039/c8bm01041b.

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Tuan, Ta Anh, Elena V. Guseva, Le Hong Phuc, Nguyen Quan Hien, Nguyen Viet Long, and Bui Xuan Vuong. "Acid-free Hydrothermal Process for Synthesis of Bioactive Glasses 70SiO2–(30-x)CaO–xZnO (x = 1, 3, 5 mol.%)." Proceedings 62, no. 1 (December 31, 2020): 6. http://dx.doi.org/10.3390/proceedings2020062006.

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Bioactive glasses 70SiO2–(30-x)CaO–xZnO (x = 1, 3, 5 mol.%) were prepared by the acid-free hydrothermal method in keeping with green chemical technology. The synthetic glasses were investigated by TG-DSC, BET, XRD, and SEM–EDX methods. All synthetic glasses present mesoporous structures consisting of aggregates of nanoparticles. The bioactivity of synthetic glasses was confirmed through the formation of the hydroxyapatite phase after an in vitro experiment in simulated body fluid (SBF) solution. The effect of Zn addition is shown through the decrease in the bioactivity of synthetic glasses. Additionally, the inductively coupled plasma optical emission spectrometry (ICP-OES) analysis indicates that the Zn ions were released from the glassy networks during in vitro experiments, and they act as Zn(OH)2 suspended precipitation to inhibit the apatite deposition. The in vitro experiment in cell culture matter was performed for SaOS2 and Eahy929 cells. The results confirm the biocompatibility of synthetic glasses and the role of Zn addition in the proliferation of living cells.

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Shen, Xiaofeng, Pengfei Yu, Hua Chen, Jiangping Wang, Binjie Lu, Xuefeng Cai, Chun Gu, et al. "Icariin controlled release on a silk fibroin/mesoporous bioactive glass nanoparticles scaffold for promoting stem cell osteogenic differentiation." RSC Advances 10, no. 20 (2020): 12105–12. http://dx.doi.org/10.1039/d0ra00637h.

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34

Baino, Francesco. "Copper-Doped Ordered Mesoporous Bioactive Glass: A Promising Multifunctional Platform for Bone Tissue Engineering." Bioengineering 7, no. 2 (May 21, 2020): 45. http://dx.doi.org/10.3390/bioengineering7020045.

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The design and development of biomaterials with multifunctional properties is highly attractive in the context of bone tissue engineering due to the potential of providing multiple therapies and, thus, better treatment of diseases. In order to tackle this challenge, copper-doped silicate mesoporous bioactive glasses (MBGs) were synthesized via a sol-gel route coupled with an evaporation-induced self-assembly process by using a non-ionic block co-polymer as a structure directing agent. The structure and textural properties of calcined materials were investigated by X-ray powder diffraction, scanning-transmission electron microscopy and nitrogen adsorption-desorption measurements. In vitro bioactivity was assessed by immersion tests in simulated body fluid (SBF). Preliminary antibacterial tests using Staphylococcus aureus were also carried out. Copper-doped glasses revealed an ordered arrangement of mesopores (diameter around 5 nm) and exhibited apatite-forming ability in SBF along with promising antibacterial properties. These results suggest the potential suitability of copper-doped MBG powder for use as a multifunctional biomaterial to promote bone regeneration (bioactivity) and prevent/combat microbial infection at the implantation site, thereby promoting tissue healing.

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35

Ballarre, Josefina, Daniel Buldain, Irem Unalan, Juan I. Pastore, Nora Mestorino, and Aldo R. Boccaccini. "Melaleuca armillaris Essential Oil as an Antibacterial Agent: The Use of Mesoporous Bioactive Glass Nanoparticles as Drug Carrier." Nanomaterials 13, no. 1 (December 21, 2022): 34. http://dx.doi.org/10.3390/nano13010034.

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Bioactive glasses have been proposed for bone tissue engineering due to their excellent biocompatibility and osteo-inductive behaviour. The generation of mesoporous bioactive glass (nano) particles adds a high surface area for the dissolution and release of bioactive ions, and the possibility to load them with different drugs for antibacterial purposes. Essential oils (EO) are an interesting resource for alternative medical therapy, providing antimicrobial compounds that come from organic/natural resources like aromatic plants. Also, a biological polymer, such as chitosan, could be used to control the release of active agents from mesoporous bioactive glass (MBG) loaded particles. This work presents MBG particles with nominal composition (in mol) 60% SiO2, 30% CaO and 10% P2O5, loaded with essential oil of Melaleuca armillaris, which contains 1,8-cineol as the main active component, with an inhibitory in vitro activity against several bacterial species. Also, co-loading with a broad-spectrum antibiotic, namely gentamicin, was investigated. The MBG particles were found to be of around 300nm in diameter and to exhibit highly porous open structure. The release of EO from the particles reached 72% of the initial content after the first 24 h, and 80% at 48 h of immersion in phosphate buffered solution. Also, the MBG particles with EO and EO-gentamicin loading presented in vitro apatite formation after 7 days of immersion in simulated body fluid. The antibacterial tests indicated that the main effect, after 24 h of contact with the bacteria, was reached either for the MBG EO or MBG EO-gentamicin particles against E. coli, while the effect against S. aureus was less marked. The results indicate that MBG particles are highly bioactive with the tested composition and loaded with EO of Melaleuca armillaris. The EO, also combined with gentamicin, acts as an antibacterial agent but with different efficacy depending on the bacteria type.

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Zhao, Lingzhi, Xiaoxia Yan, Xufeng Zhou, Liang Zhou, Hongning Wang, Jiawei Tang, and Chengzhong Yu. "Mesoporous bioactive glasses for controlled drug release." Microporous and Mesoporous Materials 109, no. 1-3 (March 2008): 210–15. http://dx.doi.org/10.1016/j.micromeso.2007.04.041.

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37

Hu, Qing, Yuli Li, Guohou Miao, Naru Zhao, and Xiaofeng Chen. "Size control and biological properties of monodispersed mesoporous bioactive glass sub-micron spheres." RSC Adv. 4, no. 43 (2014): 22678–87. http://dx.doi.org/10.1039/c4ra01276c.

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38

Wang, Duo, Chengkai Zhang, Li Ren, Dongdong Li, and Jihong Yu. "Biodegradable AIEgen-functionalised mesoporous bioactive glass nanoparticles for drug delivery and cell imaging." Inorganic Chemistry Frontiers 5, no. 2 (2018): 474–80. http://dx.doi.org/10.1039/c7qi00575j.

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39

Mo, Yunfei, Fujian Zhao, Zefeng Lin, Xiaodong Cao, Dafu Chen, and Xiaofeng Chen. "Local delivery of naringin in beta-cyclodextrin modified mesoporous bioactive glass promotes bone regeneration: from anti-inflammatory to synergistic osteogenesis and osteoclastogenesis." Biomaterials Science 10, no. 7 (2022): 1697–712. http://dx.doi.org/10.1039/d1bm01842f.

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The local delivery of naringin in beta-cyclodextrin modified mesoporous bioactive glass promotes bone regeneration via synergistic immunomodulation of osteogenesis and osteoclastogenesis by macrophages.

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40

Kang, Min Sil, Na-Hyun Lee, Rajendra K. Singh, Nandin Mandakhbayar, Roman A. Perez, Jung-Hwan Lee, and Hae-Won Kim. "Nanocements produced from mesoporous bioactive glass nanoparticles." Biomaterials 162 (April 2018): 183–99. http://dx.doi.org/10.1016/j.biomaterials.2018.02.005.

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41

Hosseinpour, Sepanta, Maria Natividad Gomez-Cerezo, Yuxue Cao, Chang Lei, Huan Dai, Laurence J. Walsh, Saso Ivanovski, and Chun Xu. "A Comparative Study of Mesoporous Silica and Mesoporous Bioactive Glass Nanoparticles as Non-Viral MicroRNA Vectors for Osteogenesis." Pharmaceutics 14, no. 11 (October 26, 2022): 2302. http://dx.doi.org/10.3390/pharmaceutics14112302.

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Micro-ribonucleic acid (miRNA)-based therapies show advantages for bone regeneration but need efficient intracellular delivery methods. Inorganic nanoparticles such as mesoporous bioactive glass nanoparticles (MBGN) and mesoporous silica nanoparticles (MSN) have received growing interest in the intracellular delivery of nucleic acids. This study explores the capacity of MBGN and MSN for delivering miRNA to bone marrow mesenchymal stem cells (BMSC) for bone regenerative purposes, with a focus on comparing the two in terms of cell viability, transfection efficiency, and osteogenic actions. Spherical MBGN and MSN with a particle size of ~200 nm and small-sized mesopores were prepared using the sol-gel method, and then the surface was modified with polyethyleneimine for miRNA loading and delivery. The results showed miRNA can be loaded into both nanoparticles within 2 h and was released sustainedly for up to 3 days. Confocal laser scanning microscopy and flow cytometry analysis indicated a high transfection efficiency (>64%) of both nanoparticles without statistical difference. Compared with MSN, MBGN showed stronger activation of alkaline phosphatase and activation of osteocalcin genes. This translated to a greater osteogenic effect of MBGN on BMSC, with Alizarin red staining showing greater mineralization compared with the MSN group. These findings show the potential for MBGN to be used in bone tissue engineering.

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42

Nawaz, Qaisar, Muhammad Atiq Ur Rehman, Judith A. Roether, Liu Yufei, Alina Grünewald, Rainer Detsch, and Aldo R. Boccaccini. "Bioactive glass based scaffolds incorporating gelatin/manganese doped mesoporous bioactive glass nanoparticle coating." Ceramics International 45, no. 12 (August 2019): 14608–13. http://dx.doi.org/10.1016/j.ceramint.2019.04.179.

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43

Turdean-Ionescu, Claudia, Baltzar Stevensson, Jekabs Grins, Isabel Izquierdo-Barba, Ana García, Daniel Arcos, María Vallet-Regí, and Mattias Edén. "Composition-dependent in vitro apatite formation at mesoporous bioactive glass-surfaces quantified by solid-state NMR and powder XRD." RSC Advances 5, no. 105 (2015): 86061–71. http://dx.doi.org/10.1039/c5ra13410b.

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Solid-state NMR and powder XRD are employed to quantify the ACP (amorphous calcium phosphate) and HCA (hydroxy-carbonate apatite) components grown from three mesoporous bioactive glasses with variable compositions.

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Schumacher, M., L. Reither, J. Thomas, M. Kampschulte, U. Gbureck, A. Lode, and M. Gelinsky. "Calcium phosphate bone cement/mesoporous bioactive glass composites for controlled growth factor delivery." Biomaterials Science 5, no. 3 (2017): 578–88. http://dx.doi.org/10.1039/c6bm00903d.

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The composites of calcium phosphate bone cements and mesoporous bioactive glass allow the controlled, local delivery of growth factors into specific bone defects while maintaining their biologic activity.

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45

Salètes, Margaux, Marta Vartin, Caroline Mocquot, Charlène Chevalier, Brigitte Grosgogeat, Pierre Colon, and Nina Attik. "Mesoporous Bioactive Glasses Cytocompatibility Assessment: A Review of In Vitro Studies." Biomimetics 6, no. 1 (January 23, 2021): 9. http://dx.doi.org/10.3390/biomimetics6010009.

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Thanks to their high porosity and surface area, mesoporous bioactive glasses (MBGs) have gained significant interest in the field of medical applications, in particular, with regards to enhanced bioactive properties which facilitate bone regeneration. The aim of this article is to review the state of the art regarding the biocompatibility evaluation of MBGs and provide a discussion of the various approaches taken. The research was performed using PubMed database and covered articles published in the last five years. From a total of 91 articles, 63 were selected after analyzing them according to our inclusion and exclusion criteria. In vitro methodologies and techniques used for biocompatibility assessment were investigated. Among the biocompatibility assessment techniques, scanning electron microscopy (SEM) has been widely used to study cell morphology and adhesion. Viability and proliferation were assessed using different assays including cell counting and/or cell metabolic activity measurement. Finally, cell differentiation tests relied on the alkaline phosphatase assay; however, these were often complemented by specific bimolecular tests according to the exact application of the mesoporous bioactive glass. The standardization and validation of all tests performed for MBG cytocompatibility is a key aspect and crucial point and should be considered in order to avoid inconsistencies, bias between studies, and unnecessary consumption of time. Therefore, introducing standard tests would serve an important role in the future assessment and development of MBG materials.

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Li, Liying, Huanrui Shi, Lu Chen, Qianxuan Yuan, Xi Chen, and Weijian Lin. "Evaluation of La-Doped Mesoporous Bioactive Glass as Adsorbent and Photocatalyst for Removal of Methylene Blue from Aqueous Solution." International Journal of Photoenergy 2015 (2015): 1–11. http://dx.doi.org/10.1155/2015/708568.

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A series of La-doped mesoporous bioactive glass (BG-La) materials with excellent biosafety and hypotoxicity have been prepared and tested as adsorbent. The study was aimed to evaluate the possibility of utilizing BG-La for the adsorptive removal of methylene blue (MB) from aqueous solution and test the adsorption and desorption behavior of this new material. The process parameters affecting adsorption behaviors such as pH, contact time, and initial concentration and the photocatalytic degradation of MB were systematically investigated. The result showed that BG-La had excellent removal rate (R) of MB, and BG-La showed better photocatalytic effect than undoped mesoporous bioactive glass (BG). Furthermore, the MB loaded BG-La was easily desorbed with acid solution due to its electronegativity and mesoporous structure. The result indicated that these materials can be employed as candidates for removal of dye pollutant owing to their high removal rate, excellent photocatalytic effect, desorption performance, and their reusability.

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Pourshahrestani, Sara, Ehsan Zeimaran, Nahrizul Adib Kadri, Nicola Gargiulo, Shani Samuel, Sangeetha Vasudevaraj Naveen, Tunku Kamarul, and Mark R. Towler. "Gallium-containing mesoporous bioactive glass with potent hemostatic activity and antibacterial efficacy." Journal of Materials Chemistry B 4, no. 1 (2016): 71–86. http://dx.doi.org/10.1039/c5tb02062j.

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Gallium-containing mesoporous bioactive glass can be considered as an efficient hemostatic material due to its merits of increased platelet adhesion and thrombin formation as well as antibacterial properties.

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Aguilar-Rabiela, Arturo E., Aldo Leal-Egaña, Qaisar Nawaz, and Aldo R. Boccaccini. "Integration of Mesoporous Bioactive Glass Nanoparticles and Curcumin into PHBV Microspheres as Biocompatible Composite for Drug Delivery Applications." Molecules 26, no. 11 (May 26, 2021): 3177. http://dx.doi.org/10.3390/molecules26113177.

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Bioactive glasses (BGs) are being increasingly considered for biomedical applications. One convenient approach to utilize BGs in tissue engineering and drug delivery involves their combination with organic biomaterials in order to form composites with enhanced biocompatibility and biodegradability. In this work, mesoporous bioactive glass nanoparticles (MBGN) have been merged with polyhydroxyalkanoate microspheres with the purpose to develop drug carriers. The composite carriers (microspheres) were loaded with curcumin as a model drug. The toxicity and delivery rate of composite microspheres were tested in vitro, reaching a curcumin loading efficiency of over 90% and an improving of biocompatibility of different concentrations of MBGN due to its administrations through the composite. The composite microspheres were tested in terms of controlled release, biocompatibility and bioactivity. Our results demonstrate that the composite microspheres can be potentially used in biomedicine due to their dual effects: bioactivity (due to the presence of MBGN) and curcumin release capability.

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López-Noriega, A., D. Arcos, I. Izquierdo-Barba, Y. Sakamoto, O. Terasaki, and M. Vallet-Regí. "Ordered Mesoporous Bioactive Glasses for Bone Tissue Regeneration." Chemistry of Materials 18, no. 13 (June 2006): 3137–44. http://dx.doi.org/10.1021/cm060488o.

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Yun, Hui-suk, Seung-eon Kim, and Yong-teak Hyeon. "Highly ordered mesoporous bioactive glasses with Im3m symmetry." Materials Letters 61, no. 23-24 (September 2007): 4569–72. http://dx.doi.org/10.1016/j.matlet.2007.02.075.

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Journal articles on the topic 'Mesoporous bioactive glasse'

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