Journal articles: 'Mesenchyme Cytology'

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Vagholkar, Ketan, Isha Bhatnagar, and Suvarna Vagholkar. "Giant lipoma over the back." International Surgery Journal 9, no. 3 (February 28, 2022): 687. http://dx.doi.org/10.18203/2349-2902.isj20220646.

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Lipoma is one of the most common soft tissue tumor arising from the mesenchyme. It is slow growing, encapsulated, and usually benign in nature. Tumors over the back, shoulder, and neck region have a high propensity to assume large size thereby getting redefined as a giant lipoma when they exceed 10 cm in width or weigh more than 1000 grams. MRI is the investigation of choice for evaluating giant lipomas. Fine needle aspiration cytology (FNAC) or frozen section may be pertinent in suspected cases of liposarcoma. Complete surgical incision is the treatment of choice. A case of a giant lipoma on the back of a 64-year-old lady is presented with a view to revisit conceptual understanding of the clinical evaluation, investigation, and management of giant lipomas.

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Permi, Harish S., Shetty K. Padma, Supriya Rai, Lakshmi Manjeera, Neetha Poojary, and Teerthanath S. "AN UNUSUAL CYTOLOGICAL EXPERIENCE OF VIRILISING OVARIAN SERTOU-LEYDIG CELL TUMOR - A RARE CASE REPORT." Journal of Health and Allied Sciences NU 03, no. 01 (March 2013): 63–65. http://dx.doi.org/10.1055/s-0040-1703636.

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AbstractSertoli-Leydig cell tumor of ovary is a gonadal tumour of the sex cord-stromal type. It is a rare tumor comprising 0.1 to 0.5% of all ovarian tumours. Peritoneal cytology has been well established as a diagnostic and staging tool in the management of the common epithelial tumours of ovary. Germ cell, mesenchymal, and sex-cord stromal tumours are much less frequently encountered in peritoneal specimens, often with cytologic features that may pose diagnostic difficulty and dilemma. We report a case of peritoneal fluid cytology of sertoli leydig cell tumor of ovary in a 20 year old female who presented with virilising symptoms. On removal of ovarian tumor, her virilising symptoms regressed, with regaining of menstruation.

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Kondapalli, Ananya, Lucas Redd, Lorraine DeBlanche, and Yin Oo. "Primary angiosarcoma of thyroid." BMJ Case Reports 12, no. 6 (June 2019): e228862. http://dx.doi.org/10.1136/bcr-2018-228862.

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Mesenchymal origin of primary thyroid angiosarcomas (TAS) is extremely rare and comprises less than 1% of primary thyroid cancer worldwide. While TAS are most commonly occurring in the Alpine region, there are multiple reported cases of TAS in non-Alpine regions. Diagnosis of TAS is commonly made after thyroidectomy as cytologic diagnosis can be challenging due to paucity of cells, presence of necrosis and unawareness of the disease due to rarity. We report a case of primary TAS diagnosed by cytology in a 56-year-old man who presented with a sudden onset of left neck pain, swelling and haemoptysis. He was later noted to have suspicious nodules on both lobes of thyroid on ultrasound. Fine needle aspiration of thyroid nodules showed malignant epithelioid cells. The diagnosis of TAS was made based on positive endothelial markers such as thrombomodulin and CD31, with many pertinent negatives, including negative cytokeratins,thyroid transcription factor (TTF1), thyroglobulin, calcitonin and carcinoembryonic antigen (CEA).

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Reardon, J. D., B. S. Hatfield, A. O. Kraft, and S. C. Smith. "Gastroblastoma: Cytologic Findings with Resection and Molecular Correlation." American Journal of Clinical Pathology 154, Supplement_1 (October 2020): S125—S126. http://dx.doi.org/10.1093/ajcp/aqaa161.275.

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Abstract Casestudy Gastroblastoma is a rare tumor with biphasic components showing epithelial and mesenchymal differentiation. To date, <15 cases have been reported, with molecular confirmation of the recently identified MALAT1-GLI1 translocations only in a subset. Aspiration cytologic and small biopsy findings have not yet been reported. We present a case of gastroblastoma, arising in a 22-year-old female. Results A CT scan was performed, showing a 7 cm heterogeneous mass in the distal stomach and pancreas, clinically suspected to represent at gastrointestinal stromal tumor (GIST). She underwent two preoperative samples, including endoscopic ultrasound guided-fine needle aspiration and core biopsy, followed by a distal gastrectomy. Diff- Quik stained touch preparations performed on the core needle biopsy during rapid on-site evaluation showed a hypercellular neoplasm composed of large, three-dimensional aggregates of neoplastic cells in a background of numerous isolated single cells and bare nuclei. The neoplastic cells were bland with spindled to epithelioid nuclei, occasional nuclear grooves, and small nucleoli. Immunostains were only helpful in excluding GIST (CD117 and DOG1 negative). Distal gastrectomy showed a nodular/plexiform tumor with variably epithelioid to spindle cell cytology and solid to focally myxoid/microcystic architecture. Pancytokeratins CAM5.2 (patchy) and AE1/AE3 (very focal) were positive, with negative S100, SMA, Desmin, Melan-A, Inhibin, Calretinin, and Synaptophysin. Based on the age, location, histology and immunophenotype, gastroblastoma was suspected, and multiplex NGS-based fusion sequencing identified a MALAT1-GLI1 fusion. Staging studies were negative for metastasis at presentation. Conclusion Based on this experience, we recommend consideration of gastroblastoma for a gastric tumor in a young patient, especially if encountering a cytologic sample showing non-pleomorphic epithelioid and spindle cell cytology. Lack of expression of GIST, smooth muscle, neuroendocrine, and neural sheath-associated markers should particularly raise consideration of this rare neoplasm. While in this case molecular studies clinched the diagnosis upon resection, increasingly used GLI1 immunostain may be of use prospectively for diagnosis of limited samples.

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Ryan, Mitchell. "Cytology and Mesenchymal Pathology:How Far Will We Go?" American Journal of Clinical Pathology 106, no. 5 (November 1, 1996): 561–64. http://dx.doi.org/10.1093/ajcp/106.5.561.

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Gupta, Ruchika, Sugandha Sharma, Sarika Verma, Lavleen Singh, Chhabi R. Gupta, and Sanjay Gupta. "Pediatric fine-needle aspiration cytology: An audit of 266 cases of pediatric tumors with cytologic-histologic correlation." Cytojournal 17 (November 2, 2020): 25. http://dx.doi.org/10.25259/cytojournal_101_2019.

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Objectives: Fine-needle aspiration cytology (FNAC), a well-accepted minimally invasive diagnostic technique utilized in adults, is gradually gaining ground for pediatric patients as well. However, there are very few comprehensive reports in the literature on utility of FNA in pre-operative diagnosis of pediatric tumors. Material and Methods: An observational study was conducted at a cancer research center and a pediatric tertiary care hospital over a 5-year period. A cytologic-histologic correlation was performed for FNACs performed in pediatric patients for a clinical diagnosis of neoplastic lesions at both the centers. Relevant clinical details and histopathology, wherever available, were retrieved. Sensitivity, specificity, and accuracy of FNAC in diagnosis of malignant lesion were calculated from the cases with available histologic correlation. Results: Of the 266 cases included, there was a slight male predominance with lymphadenopathy being the most common presentation and non-Hodgkin’s lymphoma as the most frequent diagnosis in cases clinically suspected to have a neoplasm. Histologic correlation was available in 112 cases with 100% concordance in liver and kidney tumors. Few rare cytologic diagnoses such as papillary renal cell carcinoma, mesenchymal hamartoma of the liver, and thymolipoma could be accurately rendered on FNAC smears in conjunction with the clinic-radiologic features. The sensitivity, specificity, and accuracy of FNA in diagnosing malignant pediatric tumors were found to be 100%, 92.6%, and 97.7%, respectively. Conclusion: The present study underscores the high sensitivity and accuracy of FNAC in diagnosis of pediatric tumors, both in superficial and deep-seated locations. Awareness of the cytomorphologic features and clinic-radiologic correlation may assist the cytopathologists in rendering a precise diagnosis of rare pediatric tumors as well.

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Ipek, Volkan, I. Taci Cangul, and Ahmet Akkoc. "Comparative Evaluation of the Cytological, Histopathological and Immunohistochemical Findings of Canine Cutaneous and Subcutaneous Masses." Acta Veterinaria 71, no. 1 (March 1, 2021): 61–84. http://dx.doi.org/10.2478/acve-2021-0005.

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Abstract In this study, we compared the cytological, histopathological, and immunohistochemical diagnoses of 71 canine cutaneous and subcutaneous masses. Cytological diagnoses included 56 tumors (21 mesenchymal, 15 epithelial, 16 round cell, four melanocytic), 13 inflammatory reactions, and two cysts. Of the 21 cytologically diagnosed mesenchymal tumors, three were later confirmed non-tumoral (hematoma, granulation tissue, fibroepithelial polyp). Thirteen out of 15 epithelial tumors were correctly diagnosed cytologically, whereas two cases were confirmed to be non-tumoral (fibroepithelial polyp, granulation tissue) after histopathological examination. One mast cell tumor was later confirmed as fibrous hyperplasia; diagnoses were correct in other round cell tumors. Cytological diagnoses were correct for all melanocytic tumors and cystic lesions. Five cases which had been cytologically diagnosed as inflammatory reactions were diagnosed as tumors (lymphoma, papilloma, sebaceous adenoma, and squamous cell carcinoma) after histopathological examination. Immunohistochemistry confirmed the histopathological diagnoses of all epithelial and round cell tumors, while the diagnoses of six mesenchymal tumors were changed after the immunohistochemical examination. The total accuracy of cytology in the diagnosis of tumoral/non-tumoral masses was 84.5%, and the accuracy in the determination of benign/malignant behavior was 83%. Diagnostic accordance between histopathology and immunohistochemistry was 86.6%. High success rates obtained with cytological diagnoses prove that cytology is a reliable diagnostic tool. The main diagnostic challenge remains with mesenchymal tumors and tumors accompanied by inflammatory reactions. The results suggest that immunohistochemistry is fundamental for diagnoses of most mesenchymal tumors.

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Friciello Teixeira, Rodrigo Hidalgo, André Luiz Mota da Costa, Nathália Diez Murollo, Paolla Nicole Franco, Daniel Angelo Felippi, and Caio Henrique Paganini Burini. "Fibrossarcoma in a jaguar (Panthera onca): thermography associated with aspiration cytology as diagnostic tools." Clínica Veterinária XXII, no. 126 (January 1, 2017): 72–78. http://dx.doi.org/10.46958/rcv.2017.xxii.n.126.p.72-78.

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Infrared thermography is a safe and non-invasive method of research used to aid the diagnosis of inflammation, infectious diseases and muscle damage, as well as in reproductive control. The images captured by thermography convert infrared radiation emanating from the body in a temperature gradient, represented by a pattern of visible colors. Aspiration cytology, on the other hand, is an easily applicable research tool that offers excellent preliminary results and directs the clinical case towards a diagnosis. A male jaguar (Panthera onca) presenting a tumor in the abdominal region was examined with the aid of a thermal imager and later a fine needle aspiration cytology was performed. These methods disclosed a mesenchymal malignant neoplasm; later histopathological analysis confirmed the diagnosis of fibrosarcoma. The combination of thermography with fine needle aspiration cytology provided excellent results, showing efficiency, speed and convenience as a diagnostic aid.

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Shivamurthy, Archana, and Padmapriya Jaiprakash. "Role of imprint cytology in the diagnosis of ovarian neoplasms." Indian Journal of Pathology and Oncology 8, no. 3 (August 15, 2021): 320–26. http://dx.doi.org/10.18231/j.ijpo.2021.064.

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Primary ovarian neoplasms constitute a heterogenous group of benign and malignant tumors of epithelial, sex cord–stromal, mesenchymal and germ cell origin. Secondary tumors constitute a minority. The management of benign and malignant ovarian neoplasms varies and it is here that imprint cytology plays a crucial role in diagnosis. It provides a rapid intraoperative diagnosis which will decide further treatment course for the patient. Imprint cytology of ovarian neoplasms is simple, inexpensive, challenging and provides a rapid diagnosis with excellent cellular details. The aim of the present study is to determine the role of imprint cytology in the diagnosis of ovarian neoplasms. A retrospective study was conducted in the department of pathology. A total of 53 cases were included in the study. In 48 cases, the imprint cytology findings correlated with the histopathological diagnosis. 5 cases did not correlate. Epithelial ovarian tumors accounted for the majority, (85%) followed by germ cell tumors (9.4%) and sex cord stromal tumors (5.6%). The sensitivity and specificity were 93.75% and 100% respectively. Thus imprint cytology is an effective cytological method in the diagnosis of ovarian neoplasms. Knowledge of specific cytological features for each tumor type helps in accurate diagnosis which in turn is valuable in immediate appropriate treatment and management of patients with benign or malignant neoplasms.

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Felizzola, Cláudia Ronca, Angelo João Stopiglia, and Ney Soares de Araújo. "Oral tumors in dogs: clinical aspects, exfoliative cytology and histopathology." Ciência Rural 29, no. 3 (September 1999): 499–506. http://dx.doi.org/10.1590/s0103-84781999000300020.

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In order to establish the diagnosis and prognosis of tumors of the oral cavity, a comparative study was carried out in 130 dogs considering age, sex, breed, clinical aspects, exfoliative cytology as well as histopathology. Exfoliative cytology revealed: 100% negative for benign non-odontogenic tumors, 97.91% negative benign odontogenic tumors and 77.92% positive for malignant tumors. Histopathology showed: 59.23% malignant tumors (33.08% malignant melanoma, 9.23% squamous cell carcinoma, 5.38% osteosarcoma, 2.31% fibrosarcoma, 2.31% angiosarcoma, 1.54% malignant mesenchymal tumors, 1.54% malignant fibrohistiocytoma, 1.54% lymphoma, 0.77% leyomyosarcoma, 0.77%% epithelioid sarcoma and 0.77% angiofibrosarcoma); 36.92% benign odontogenic tumors (25.38% peripheral odontogenic fibroma, 10.0% ossifyng fibroma and 1.54% odontoma) in addition to 3.85% benign non-odontogenic tumors (1.54% fibroma, 0.77% plasmocytoma, 0.77% pilomatrixoma and 0.77% giant tumor cells). These results permit us to conclude that exfoliative cytology was an efficient, safe, quick and noninvasive method and could be used for early evaluation of oral cancer.

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Morimura, Yutaka, Keiya Fujimori, Tomoko Sato, Takafumi Watanabe, and Akira Sato. "Imprint Cytology of Extraskeletal Mesenchymal Chondrosarcoma of the Perineum." Acta Cytologica 48, no. 5 (2004): 649–52. http://dx.doi.org/10.1159/000326437.

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Parajuli, S., and M. Lakhey. "Efficacy of fine needle aspiration cytology in diagnosing soft tissue tumors." Journal of Pathology of Nepal 2, no. 4 (September 25, 2012): 305–8. http://dx.doi.org/10.3126/jpn.v2i4.6884.

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Background: Fine needle aspiration cytology has an established role in the diagnosis of various neoplastic and non-neoplastic lesions. Its accuracy when applied by experienced and well trained practitioners matches that of histopathology in providing an equivocal diagnosis; so it can also be used as a very useful alternative to excision biopsy in the diagnostic workup of soft tissue tumors.Materials and Methods: This retrospective study was done in the Department of Pathology, Kathmandu Medical College for a period of one year from January 2006 to December 2006. A total of 60 cases presented with soft tissue tumors, of which only 50 were biopsied and the correlation done. A detailed history, clinical findings, routine relevant laboratory investigations and radiological findings were carried.Results: Fine needle aspiration cytology revealed diagnostic materials in 47 cases and 3 cases were inconclusive for a definite diagnosis. 40 cases were diagnosed as benign lesions and 7 cases as malignant lesions. Out of the benign cases, the most common were lipomas which accounted for 52.5% of cases followed by benign mesenchymal tumor- 17.5%. Out of the malignant cases 71.42% were diagnosed as malignant mesenchymal tumor and 28.57% as malignant nerve sheath tumor. The overall diagnostic accuracy of fine needle aspiration cytology in soft tissue tumors in the present study was 86%. The sensitivity and specificity of diagnosing benign soft tissue tumors was 97.36% and 66.67% respectively and for malignant soft tissue tumors 66.67% and 97.36% respectively.Conclusion: Fine needle aspiration cytology can be effective and reliable diagnostic tool in the evaluation of soft tissue tumors. It is highly sensitive to detect benign soft tissue tumors and highly specific for malignant soft tissue tumors.Journal of Pathology of Nepal (2012) Vol. 2, 305-308DOI: http://dx.doi.org/10.3126/jpn.v2i4.6884

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Kakkar, Aanchal, Sandeep R. Mathur, Deepali Jain, Venkateswaran K. Iyer, Aasma Nalwa, and Mehar C. Sharma. "Utility of DOG1 Immunomarker in Fine Needle Aspirates of Gastrointestinal Stromal Tumor." Acta Cytologica 59, no. 1 (2015): 61–67. http://dx.doi.org/10.1159/000370057.

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Background: Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract. DOG1 is a sensitive and specific immunohistochemical marker for the diagnosis of GIST. To date, no study has reported the utility of DOG1 immunocytochemistry on aspirate smears. Methods: Aspirates with a cytological diagnosis of GIST were retrieved. DOG1 immunocytochemistry was performed on aspirates with adequate material. Results: 23 cases were included (11 primary, 2 recurrent, 10 metastatic). Primary tumors were most frequently located in the stomach; most metastatic tumors were in the liver. Tumor cells were arranged in cohesive clusters with high cellularity. Cells were spindled, had a low N:C ratio, and a moderate amount of cytoplasm, which was elongated and tapering. Characteristic nuclear features included elongated nuclei with blunt or tapering ends, fine chromatin, mild anisonucleosis, and longitudinal grooves. The mitotic count was low, including in metastatic tumors. DOG1 immunopositivity was noted in 57% of the cases examined. Histopathology was available in 5 cases, all diagnosed as GIST. Conclusion: Cytology is a sensitive investigative modality for the preoperative diagnosis and confirmation of metastasis of GISTs. In ambiguous cases, DOG1 immunocytochemistry can serve as a valuable adjunct. Cytologic assessment, however, cannot predict malignant potential of GISTs as even metastatic tumors display bland nuclear features.

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Adlekha, Shashikant, Tandra Chadha, A. Ragunath, B. Sumangala, and Robin George. "Intraoperative diagnosis of glioblastomamultiforme with oligodendroglial and sarcomatous components." Journal of Neurosciences in Rural Practice 6, no. 01 (January 2015): 081–83. http://dx.doi.org/10.4103/0976-3147.143207.

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ABSTRACTGlioblastoma, the most frequent primary brain tumor and the most malignant neoplasm, can have the most heterogeneous morphological presentation. Along with classical morphological features, areas of oligodendroglial component and mesenchymal differentiation may be seen. The present case was a rare case of glioblastoma presenting with sarcomatous and oligodendroglial components. The case was diagnosed intraoperatively by squash and touch cytology and later on confirmed by histopathological study.

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Bottero, Enrico, Maverick Melega, Erika R. Dimartino, Michele Tricarico, Elvio Lepri, Davide De Lorenzi, Barbara Miniscalco, and Fulvio Riondato. "Diagnosis of feline mesenchymal nasal hamartoma by squash preparation cytology." Veterinary Clinical Pathology 47, no. 4 (October 31, 2018): 629–33. http://dx.doi.org/10.1111/vcp.12667.

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Cian, Francesco. "Cytology (part 4): cutaneous lesions of epithelial and mesenchymal origin." Companion Animal 19, no. 11 (November 2, 2014): 568–72. http://dx.doi.org/10.12968/coan.2014.19.11.568.

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Al-Rikabi, Ammar C., Amer Buckai, Saleh Al-Sumayer, Saleh Al-Damegh, and Abdul R. Al-Bassam. "Fine Needle Aspiration Cytology of Mesenchymal Hamartoma of the Liver." Acta Cytologica 44, no. 3 (2000): 449–53. http://dx.doi.org/10.1159/000328497.

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Jim�nez-Heffernan, Jos� A., Blanca Vicandi, Pilar L�pez-Ferrer, Manuel Lamas, and Jos� M. Viguer. "Fine-needle aspiration cytology of mesenchymal hamartoma of the liver." Diagnostic Cytopathology 22, no. 4 (April 2000): 250–53. http://dx.doi.org/10.1002/(sici)1097-0339(200004)22:4<250::aid-dc11>3.0.co;2-3.

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Silverman, Jan F., Kim R. Geisinger, and William J. Frable. "Fine-needle aspiration cytology of mesenchymal tumors of the breast." Diagnostic Cytopathology 4, no. 1 (January 1988): 50–58. http://dx.doi.org/10.1002/dc.2840040113.

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Logroño, Roberto, Bill A. Rampy, and Patrick A. Adegboyega. "Fine needle aspiration cytology of hepatobiliary cystadenoma with mesenchymal stroma." Cancer 96, no. 1 (February 1, 2002): 37–42. http://dx.doi.org/10.1002/cncr.10315.

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Nicholson, Siobhan A., Dana A. Hill, Kirk W. Foster, William H. McAlister, Rosa M. Davila, and Louis P. Dehner. "Fine-needle aspiration cytology of mesenchymal hamartoma of the chest wall." Diagnostic Cytopathology 22, no. 1 (January 2000): 33–38. http://dx.doi.org/10.1002/(sici)1097-0339(200001)22:1<33::aid-dc10>3.0.co;2-a.

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Khan, Alam Khalil, Thomas Baboolal, Owen Wall, Elena Jone, and Dennis Mcgonagle. "Mobilisation of Joint-resident Mesenchymal Stromal Cells for Articular Cartilage Regeneration." Orthopaedic Journal of Sports Medicine 5, no. 2_suppl2 (February 1, 2017): 2325967117S0007. http://dx.doi.org/10.1177/2325967117s00079.

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Background and Objectives: Microfracture is a recognized procedure used to treat isolated cartilage injuries or defects, in which bone marrow mesenchymal stromal cells (BM-MSCs) are thought to migrate into the resulting blood clot, leading to subsequent cartilage repair via fibrocartilage formation. The discovery of MSCs in the synovium and synovial fluid (SF) provides a potential mechanism for repairing cartilage from the top down via their migration and homing to the microfracture site, however SF-MSCs low in number and usually lost with joint irrigation. The purpose of this work was threefold; first to test the hypothesis that SF-MSCs can be replaced, and also their numbers further increased by synovial agitation, second that these cells were capable of rapid adhesion to clots and third that the clot composition improve MSC migration. Materials-Methods: Ex-vivo mechanical agitation of human superficial synovium and in vivo intra-operative agitation of synovium in patients undergoing arthroscopy were performed using a Cytology brush and custom designed Synovial brush. Colony-forming unit-fibroblast (CFU-F) assay was performed to quantify released MSCs. Adhesion to clots was studied by comparing Platelet Rich Plasma (PRP), Whole Blood (WB) and Fibrin Glue (FG). Migration studies were performed using passage 2-4 synovial MSCs in trans-well migration assay. MSC migration, over a five hour period, was compared between PRP and pooled human Platelet Lysate (hPL). Results: Ex-vivo mechanical agitating of the synovium with the cytology brush compared to irrigation alone increased MSC number 2.7-fold (n=10, p=0.002). Irrigation during arthroscopy was seen to effectively remove the majority of CFU-Fs for the synovial fluid. Use of a custom designed synovial brush, compared to the cytology brush resulted in a median 65-fold increase in the number of CFU-Fs (n=8, p=0.0148). Trilineage differentiation of released synovial MSCs was at least comparable to donor match synovial fluid MSCs. These MSCs adhered to clots within 30 minutes with no difference seen between clot compositions. Released synovial MSCs demonstrated a trend for a better migration towards hPL compared to PRP. Conclusions: Existing surgical procedures wash away SF-MSCs. Using a novel brushing technique and a custom designed synovial brush, synovial MSCs can be mechanically released in vivo, and these cells were capable of migration and rapid adhesion to clots. Collectively these findings aid in the rapid replenishment of endogenous minimally manipulated MSCs, and provide a one-stage procedure combining synovial brushing with microfracture, as a strategy for cost effective joint repair.

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Mathur, Sandeep R., Ruchika Gupta, Ashu Seith, Sandeep Agarwala, Subramanian Subramanian, and Datta Gupta. "Aspiration Cytology of Mesenchymal Hamartoma of the Chest Wall in an Infant." Acta Cytologica 54, no. 1 (2010): 63–65. http://dx.doi.org/10.1159/000324969.

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Huber, Doroteja, Tonka Ristevski, Andrea Gudan Kurilj, Maja Maurić, Lidija Medven Zagradišnik, Marko Hohšteter, and Ivan-Conrado Šoštarić-Zuckermann. "Prevalence of pathological lesions diagnosed by cytology in cats, with association of diagnosis to age, breed and gender." Veterinarski arhiv 91, no. 2 (April 15, 2021): 169–77. http://dx.doi.org/10.24099/vet.arhiv.0834.

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Cytology is the diagnostic procedure of the microscopic evaluation of cells. It is becoming increasingly important and more frequently used in veterinary diagnostics, having many advantages including simplicity, speed and low cost. To determine the pathological changes diagnosed by cytology in cats, as well as the distribution of age, breed and gender in the diagnosed changes, we performed a retrospective study on slides submitted to the Department of Veterinary Pathology for routine cytological examination. The archive was searched for all feline cytology slides submitted from 2009 to 2018. All the slides were re-evaluated and classified into one of the four pathological processes: ‘neoplasia’, ‘inflammation’, ‘other condition’ or ‘non-diagnostic sample’. Breed, age, gender and the tissue from which the lesion was sampled were noted from the submission form, and statistically analyzed. The most frequent type of pathological process diagnosed was neoplasia, which reflects the high prevalence of neoplastic diseases in cats reported in literature data. Pathological changes were mostly diagnosed in domestic shorthaired cats of both sexes, with an average age of 8.4 years, but no breed, age or gender predisposition was found. The most evaluated tissue was skin, probably due to its accessibility and the ease of obtaining a sample from skin lesions. The most frequent neoplasia were malignant and the most frequent diagnosis was round cell neoplasia. Cats affected with round cell neoplasia had a significantly lower average age (7.3 years) than cats diagnosed with epithelial and mesenchymal neoplasia (9.9 and 10.3 years, respectively), probably reflecting the common retroviral infection in Croatian cats.

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Papke, David J., and Vickie Y. Jo. "Practical Application of Cytology and Core Biopsy in the Diagnosis of Mesenchymal Tumors." Surgical Pathology Clinics 12, no. 1 (March 2019): 227–48. http://dx.doi.org/10.1016/j.path.2018.11.002.

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Taavitsainen, M., L. Krogerus, and S. Rannikko. "Aspiration Biopsy in Renal Angiomyolipoma." Acta Radiologica 30, no. 4 (July 1989): 381–82. http://dx.doi.org/10.1177/028418518903000410.

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Ultrasound guided aspiration biopsy of renal mass lesions was performed in 56 patients in whom renal cell carcinoma could not be excluded due to equivocal imaging results. Cytology showed non-malignant mesenchymal cells consistent with angiomyolipoma in 12 patients. In 5 of these patients the diagnosis was ensured by open biopsy. No nephrectomy was performed. In 6 of the 7 patients not operated upon the tumours remained unchanged with no evidence of malignancy during a 3–36 months' follow-up period. Aspiration biopsy is an easy and safe method for diagnosing renal angiomyolipoma in cases where computed tomography is not diagnostic for this disease.

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MYLONAKIS (Μ.Ε. ΜΥΛΩΝΑΚΗΣ), M. E., A. F. KOUTINAS (Α.Φ. ΚΟΥΤΙΝΑΣ), and M. KRITSEPI-KONSTANTINOU (Μ. ΚΡΙΤΣΕΠΗ-ΚΩΝΣΤΑΝΤΙΝΟΥ). "Lymph node cytology in the dog and cat." Journal of the Hellenic Veterinary Medical Society 57, no. 4 (November 29, 2017): 330. http://dx.doi.org/10.12681/jhvms.15063.

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Lymph node (LN) cytology, a cost-effective and highly rewarding diagnostic technique, is performed routinely in the everyday practice. Localised or generalised lymphadenomegaly and clinical staging of malignant tumors comprise the main indications of this valuable diagnostic modality. The superficial and easily palpated submandibular, prescapular and popliteal LN can be easily positioned, while internal LN (i.e. mediastinal, mesenteric, sublumbar) may necessitate a surgical exploration or ultrasound guidance. Fine-needle biopsy and imprint smears from excised LN are the most common techniques to obtain the necessary material. Small lymphocytes constitute more than 80% of the normal LN population, with medium and large lymphocytes making up approximately the 5-15% of it. The occasional presence of plasma and mast cells, neutrophils, eosinophils and macrophages can also be noticed. Lymphadenomegaly, either localised or generalised, is mainly due to hyperplasia, inflammation or neoplasia. Hyperplastic LN may appear normal cytologically, but typically, small lymphocytes predominate (>50% of nucleated cells [NC]), in the context of a moderate increase of medium/large lymphocytes (<20%of NC) and plasma cells (>5% of NC). Hyperplastic lymphadenopathy is indicative of a lymphoid proliferation secondary to a local (e.g. deep staphylococcal pyoderma) or generalised (e.g. leishmaniosis) antigenic stimulation. In primary or secondary lymphadenitis, LN are infiltrated by increased numbers of inflammatory cells, the predominance of which define the neutrophilic or purulent, eosinophilic, granulomatous or pyogranulomatous inflammation. Bacterial (e.g. Mycobacterium sp.), fungal (e.g. Histoplasma capsulatum) and protozoal (e.g. Leishmania infantum) infections, represent the leading etiologies of canine and feline lymphadenitis. In lymphoma, the most common neoplastic lymphadenopathy in both animal species, the predominance of medium and large (> 50% of NC) immature lymphocytes is observed. Metastatic neoplasia can be documented when non-lymphoid malignant cells (i.e. epithelial, mesenchymal) or increased numbers of normally present cells (i.e. mast cells), also bearing malignant features, are detected on LN cytology. Failure to establish a definitive diagnosis on LN cytology warrants a surgical biopsy and histopathology.

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Colón, Eugenia. "Metastasis of Uterine Leiomyosarcoma to the Breast: Medical and Histopathological Criteria." Case Reports in Pathology 2020 (December 18, 2020): 1–5. http://dx.doi.org/10.1155/2020/8037646.

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It is uncommon for extramammary tumors to metastasize to the breast, and very few cases describing metastasis of primary uterine leiomyosarcoma to the breast have been reported. We present the case of a 51-year-old woman diagnosed with metastasis of uterine leiomyosarcoma to the breast diagnosed 10 years ago after hysterectomy. Ultrasonography, mammography, and cytology were used to establish a preliminary diagnosis that was confirmed upon examination of the excised tumor that show a rare soft tissue tumor composed of atypical spindle cells and increased proliferation rate. We discuss the importance of distinguishing between various primary mesenchymal tumors of the breast because of phenotypic overlap and some guidance of the histological criteria for metastasis of leiomyosarcoma, as well as differential diagnosis and surgical treatment.

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Parisi, Francesca, Francesca Abramo, Marco Maimone, Alessandro Poli, and Francesca Millanta. "Skin Photodamage Lesions in a Bilateral Feline Auricular Primary Fibrosarcoma." Veterinary Sciences 9, no. 10 (October 5, 2022): 548. http://dx.doi.org/10.3390/vetsci9100548.

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As with human species, recent studies also suggest a photoinduced etiopathology for non-epithelial cutaneous tumors in feline species. We report a recent case of a ten-year-old male cat with a white-hair coat and mesenchymal neoplasms of both auricles. Cytology, complete blood count (CBC), serum biochemistry and imaging examinations were performed. After surgery, the samples underwent routinary histopathology and were additionally stained with orcein. A routine analysis yielded values within a normal range and the imaging examination showed no abnormalities, suggesting that the bilateral presentation of neoplasms was primary rather than metastatic. The cytology was inconclusive, but, through histopathology, two well-differentiated fibrosarcomas were diagnosed and histopathological changes related to chronic UV exposure (such as epidermal hyperplasia, stratification disorders, keratinocyte dysplasia and an accumulation of elastotic material) were documented in the skin adjacent to the lesions. An orcein stain succeeded in highlighting elastosis. The elastic fibers lost their regular structure and orientation and appeared to be fragmented, wavy to branched and knotted. A morphometric analysis showed that the amount of elastotic material in the dermis close to the tumors was more than double compared with the more distant areas. Elastosis is considered to be a hallmark of photodamage; thus, an involvement of UV rays in the carcinogenic process of the tumors may be suspected.

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Höinghaus, R., M. Hewicker-Trautwein, and R. Mischke. "Immunocytochemical differentiation of canine mesenchymal tumors in cytologic imprint preparations." Veterinary Clinical Pathology 37, no. 1 (March 2008): 104–11. http://dx.doi.org/10.1111/j.1939-165x.2008.00017.x.

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Navarrete, F., F. Saravia, G. Cisterna, F. Rojas, L. Rodríguez-Alvarez, D. Rojas, and F. Castro. "210 Horse allogeneic mesenchymal stem cells perform homing and ameliorate endometrial inflammation after induced endometritis of mares." Reproduction, Fertility and Development 32, no. 2 (2020): 233. http://dx.doi.org/10.1071/rdv32n2ab210.

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Post-mating induced endometritis (PMIE) is an acute inflammatory response of the endometrium to spermatozoa, linked to an incapability of some mares to drain out the fluids associated with inflammation. This is of pivotal importance for reproductive success in mares. Mesenchymal stem cells (MSCs) are potential candidates for anti-inflammatory uterine therapies. Here, we aimed to study inflammatory markers in the endometrium of healthy mares and of those with induced endometritis, before and after intrauterine inoculation of MSCs, and to characterise their homing potential invivo in an induced endometritis horse model. Nine mares during their ovulatory season were selected after gynaecologic examination (absence of free liquid in the uterus, no polymorphonuclear leucocytes (PMNs) at cytology, negative bacteriology, and grade I in Kenney's scale on uterine biopsies). Mares were infused in the uterine body with 2mL of 500×106 spermmL−1 previously killed by repeated frozen-thawing cycles. At 3h, uteri were flushed with 250mL of sterile saline and the inflammatory response was monitored in the lavages and biopsies. Parameters measured included cytology, protein expression of inflammatory markers (supernatant) after lavage centrifugation (800×g, 10min), ELISA, and immunostaining for interleukin (IL)-6 and tumor necrosis factor alpha (TNFα). The mares were divided into three groups (3 mares each). Then, 24h after dead sperm challenge, group 1 received intrauterine infusion of 2×107 adipose MSC in 0.9% sterile saline; group 2, received the same amount of endometrial MSCs in the same vehicle; and group 3 received only saline. The volume of infusion in the uterine body was 20mL for all groups. Cells (passage 4) were previously labelled with 10μM Vybrant CFDA SE Cell Tracer Kit (ThermoFisher Scientific). After 48h, the same lavages, biopsies, and measurements as described above were performed. Additional biopsies were taken at Days 10 and 30 after intrauterine infusions. Biopsies were split in two, one for confocal microscopy and the other for quantitative PCR. Endometritis was induced in all mares, as judged by cytology and expression of protein markers of inflammation. After 48h, reduction in IL-6 and TNFα was detected by immunostaining of biopsies and confirmed by ELISA in the lavages, as well as by PCR. Homing was detected in all mares infused with MSC and it persisted at Days 10 and 30 after infusion. No homing was found in the control mares. As a result of these experiments, we conclude that inoculation of MSCs significantly reduced inflammation independently of the origin of the cells (adipose or endometrial). Both types of cells were nested in the endometrium at low quantities, although the number of cells actually detected at fixed time points was not quantified. Overall, we can propose that, given the number of homed cells detected and the marked decrease in inflammatory markers after inoculation of cells, MSCs exert their anti-inflammatory function preferentially by a paracrine mechanism and not necessarily by nesting and proliferation, although both events occur. Funding for this study was provided by Fondecyt 1150757.

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Xie, Jianwu, Cufeng Pu, and Jan F. Silverman. "Fine-Needle Aspiration Cytology of Intranodal Palisaded Myofibroblastoma of the Inguinal Lymph Node." Acta Cytologica 60, no. 1 (2016): 89–92. http://dx.doi.org/10.1159/000445162.

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Background: Intranodal palisaded myofibroblastoma (IPM) is a rare, lymph node mesenchymal neoplasm; the cytologic features are limited in the literature. Case: The patient was a 51-year-old female who had a firm, palpable mass in the right inguinal region. Fine-needle aspiration (FNA) was performed. The smears revealed large, 3-dimensional clusters of cohesive spindle cells, densely surrounding a central, orange-colored, acellular matrix core. These cells had a single, elongated nucleus and an inconspicuous nucleolus. Also seen were spindle cells in short fascicles with dense cytoplasm. The spindle cells were loosely arranged in a single-cell pattern. In addition to the spindle cells and matrix, hemosiderin granules were scattered in the background. A few lymphocytes were identified. Conclusion: A diagnosis of IPM should be considered when FNA smears of lymph node show bland spindle cells in various patterns including single cells, short fascicles, large cohesive clusters with core amianthoid fibers and background hemosiderin granules.

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Rani, Deepa, Kanika Rastogi, and Atul Gupta. "Cytomorphological study of mesenchymal spindle cell lesions of soft tissues by fine needle aspiration cytology." Indian Journal of Pathology and Oncology 5, no. 4 (November 15, 2018): 542–47. http://dx.doi.org/10.18231/2394-6792.2018.0105.

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MURATA, Kazuya, Akihiko KAWAHARA, Yoshiki NAITO, Eiji SADASHIMA, Hideyuki ABE, Yorihiko TAKASE, Chihiro FUKUMITSU, et al. "Cytological features of epithelial-mesenchymal transition cells in effusion cytology in cases of pancreatic cancer." Journal of the Japanese Society of Clinical Cytology 61, no. 2 (2022): 107–15. http://dx.doi.org/10.5795/jjscc.61.107.

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Mahajan, Nidhi, Swapnil Aggarwal, Nita Khurana, Shyama Jain, and Achal Gulati. "Ganglioneuroma in the neck masquerading as a benign mesenchymal lesion on cytology: a morphological mimic." Cytopathology 24, no. 1 (August 19, 2011): 65–67. http://dx.doi.org/10.1111/j.1365-2303.2011.00904.x.

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Taweevisit, Mana, Panruethai Trinavarat, and Paul Scott Thorner. "Aspiration cytology of mesenchymal hamartoma of the chest wall: A case report and literature review." Diagnostic Cytopathology 42, no. 10 (February 14, 2014): 890–94. http://dx.doi.org/10.1002/dc.23072.

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Caraway, Nancy P., Davide Salina, Michael T. Deavers, Rodolfo Morice, and Gene Landon. "Pulmonary artery intimal sarcoma diagnosed using endobronchial ultrasound-guided transbronchial needle aspiration." CytoJournal 12 (February 18, 2015): 3. http://dx.doi.org/10.4103/1742-6413.151667.

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Intimal sarcoma of the pulmonary artery is a rare intraluminal malignant neoplasm that has an aggressive biological behavior, and early diagnosis may improve patient outcome. We describe a case of pulmonary artery intimal sarcoma diagnosed on cytologic material obtained by endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) biopsy with rapid on-site evaluation (ROSE). The aspirate showed loosely cohesive clusters of pleomorphic malignant spindled and epithelioid cells. An immunostain panel did not demonstrate any definitive mesenchymal or epithelial differentiation. The tumor's intraluminal origin was supported by radiographic imaging studies. Subsequently, the patient received preoperative chemotherapy and underwent tumor resection with reconstruction. This report describes the cytomorphologic features of this rare intravascular tumor and demonstrates how EBUS-TBNA with ROSE was instrumental in obtaining optimal cytologic sampling for ancillary studies, thus expediting the management.

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Viswambharan, Vivek, M. Lakshmi Narayana, N. Reddy Chaithanya, B. N. Kumarguru, and Bijjam Sushma. "A rare case of mesenchymal hamartoma of cheek masquerading as hemangioma." International Journal of Otorhinolaryngology and Head and Neck Surgery 6, no. 1 (December 23, 2019): 200. http://dx.doi.org/10.18203/issn.2454-5929.ijohns20195714.

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<p class="abstract">Hamartomas are non-neoplastic, tumor-like masses characterized by irregular overgrowth in tissues of its origin, resulting from inborn errors that occur during embryonic development and are present from birth. They may develop from any of the three germinal layers of which mesodermal-derived overgrowth is the most common. Hamartomas may be seen anywhere in the body and most often arises from lung, liver, spleen, kidney, gastrointestinal tract, and rarely in the head and neck region. A 23-year-old lady presented with a painless left cheek swelling for three months. On clinical examination, she had a single, firm and ill-defined swelling of size 2×1cms in left cheek. Ultrasound examination showed an ill-defined hypoechoic lesion measuring 2.1×0.8 cms in the intramuscular compartment of left cheek with few cystic areas. On colour doppler there was minimal peripheral vascularity and flow signal suggesting capillary hemangioma. In view of the tumor’s vascularity, Fine needle aspiration cytology wasn’t performed and she was treated conservatively on oral propranolol. But since no significant response was noted, excision biopsy was done under general anesthesia. The histopathology features were consistent with mesenchymal hamartoma. Post-operative period was uneventful, and she was in regular follow up with no recurrence.</p>

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Sharma, BK, SK Khanna, M. Bharati, and A. Gupta. "Anterior Neck Lipoma with Anterior Mediastinal Extention – A Rare Case Report." Kathmandu University Medical Journal 11, no. 1 (September 11, 2014): 88–90. http://dx.doi.org/10.3126/kumj.v11i1.11048.

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Lipomas are the most common benign mesenchymal tumour. Thirteen percent of lipomas are seen in head and neck region. Anterior neck lipoma is a rare one. Anterior neck lipoma with mediastinal extension is extremely rare. We are presenting a case of 52 years old male reported to Central Referral Hospital, Sikkim Manipal Institute of Medical Sciences, Gangtok, Sikkim with complains of swelling in left side of neck for last 18 months along with occasional history of dyspnoea. Physical examination, ultrasound, computed tomography and fine needle aspiration cytology are in favor of lipoma. Due to its location up to the anterior mediastinum, the surgery could not be done in this hospital and patient was referred to higher center having cardio-thoracic surgical back up. DOI: http://dx.doi.org/10.3126/kumj.v11i1.11048 Kathmandu University Medical Journal Vol.11(1) 2013: 88-90

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Chang, Fuju. "Desmoplastic Small Round Cell Tumors: Cytologic, Histologic, and Immunohistochemical Features." Archives of Pathology & Laboratory Medicine 130, no. 5 (May 1, 2006): 728–32. http://dx.doi.org/10.5858/2006-130-728-dsrctc.

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Abstract Desmoplastic small round cell tumor (DSRCT) is a recently recognized clinicopathologic entity that has a predilection for adolescent males and usually affects the abdominal cavity. Due to its uncommon nature, many pathologists lack experience with this tumor. The literature regarding DSRCT is reviewed with special attention to its histologic and cytologic diagnosis. Morphologic features of DSRCT and its immunohistochemical and cytogenetic profile are summarized and differential diagnosis with other small round cell tumors is discussed. As observed by both histologic and cytologic examinations, small round blue cells and fibrosclerotic stroma are the striking morphologic features of DSRCT. The typical immunohistochemical profile is characterized by coexpression of epithelial, mesenchymal, myogenic, and neural markers. Cytogenetically, this tumor harbors a specific karyotypic abnormality, namely t(11;22)(p13;q12). These features distinguish DSRCT from other members of the family of small round cell tumors.

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Debeljak-Martacic, Jasmina, Jelena Francuski, Tijana Luzajic, Nemanja Vukovic, Slavko Mojsilovic, Neda Drndarevic, Marijana Petakov, et al. "Characterization of deciduous teeth stem cells isolated from crown dental pulp." Vojnosanitetski pregled 71, no. 8 (2014): 735–41. http://dx.doi.org/10.2298/vsp1408735d.

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Background/Aim. The last decade has been profoundly marked by persistent attempts to use ex vivo expanded and manipulated mesenchymal stem cells (MSCs), as a tool in different types of regenerative therapy. In the present study we described immunophenotype and the proliferative and differentiation potential of cells isolated from pulp remnants of exfoliated deciduous teeth in the final phase of root resorption. Methods. The initial adherent cell population from five donors was obtained by the outgrowth method. Colony forming unit-fibroblast (CFU-F) assay was performed in passage one. Cell expansion was performed until passage three and all tests were done until passage eight. Cells were labeled for early mesenchymal stem cells markers and analysis have been done using flow cytometry. The proliferative potential was assessed by cell counting in defined time points and population doubling time was calculated. Commercial media were used to induce osteoblastic, chondrogenic and adipogenic differentiation. Cytology and histology methods were used for analysis of differentiated cell morphology and extracellular matrix characteristics. Results. According to immunophenotype analyses all undifferentiated cells were positive for the mesenchymal stem cell markers: CD29 and CD73. Some cells expressed CD146 and CD106. The hematopoietic cell marker, CD34, was not detected. In passage one, incidence of CFU-F was 4.7 ? 0.5/100. Population doubling time did not change significantly during cell subcultivation and was in average 25 h. After induction of differentiation, the multicolony derived cell population had a tri-lineage differentiation potential, since mineralized matrix, cartilage-like tissue and adipocytes were successfully formed after three weeks of incubation. Conclusion. Altogether, these data suggest that remnants of deciduous teeth dental pulp contained cell populations with mesenchymal stem cell-like features, with a high proliferation and trilineage differentiation potential and that these cultures are suitable for further in vitro evaluation of cell based therapies.

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Kwon, Meeae Y., and Mai Gu. "True Malignant Mixed Tumor (Carcinosarcoma) of Parotid Gland With Unusual Mesenchymal Component." Archives of Pathology & Laboratory Medicine 125, no. 6 (June 1, 2001): 812–15. http://dx.doi.org/10.5858/2001-125-0812-tmmtco.

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Abstract True malignant mixed tumor (carcinosarcoma) of the salivary gland is an extremely rare tumor. By definition, it is composed of both malignant epithelial and malignant mesenchymal elements. The most common type of the former is squamous cell carcinoma or adenocarcinoma and the most common type of the latter is chondrosarcoma, followed in frequency by fibrosarcoma, leiomyosarcoma, osteosarcoma, and in rare instances liposarcoma. We report a case of true malignant mixed tumor of the parotid gland in association with a pleomorphic adenoma in a 47-year-old man that contained a very unusual type of malignant mesenchymal component, rhabdomyosarcoma. Cytologic and histologic features and immunohistochemical results are presented. In addition, the literature is reviewed, and the possible histogenesis and pathogenesis of malignant mixed tumor of the salivary gland are briefly discussed.

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Gupta, Ruchika, Richa Gupta, Kalpana Bansal, and Anup Mohta. "Aspiration cytology of mesenchymal hamartoma of the liver: Report of a Case and Review of Literature." Diagnostic Cytopathology 41, no. 5 (February 1, 2012): 434–36. http://dx.doi.org/10.1002/dc.22824.

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Gopika, A., N. Shilpa, and B. Kusumanjali. "An approach to axillary swellings cytomorphological (fine needle aspiration cytology) study." Asian Journal of Medical Sciences 13, no. 4 (April 1, 2022): 151–55. http://dx.doi.org/10.3126/ajms.v13i4.43087.

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Background: The axilla, a triangular area which is located between the upper arm and thorax, contains blood vessels, nerves, lymph nodes, and fat. Axillary swellings can arise from these various mesenchymal tissues present in the axillary area. The most common palpable axillary masses are usually lymph nodes. Fine needle aspiration cytology (FNAC) is the first line investigative technique with differential diagnosis includes reactive hyperplasia, inflammatory conditions, granulomatous disorders and malignancy. FNAC is a rapid, less invasive, less traumatic, and easily accessible and a cheap diagnostic tool to differentiate the benign or the malignant nature of the swelling. Aims and Objectives: Study is undertaken to document the spectrum of axillary lesions. Value of FNAC as a rapid diagnostic tool in diagnosing the axillary lesions. Materials and Methods: Present study is an 18 months cross-sectional study carried out in department of pathology, tertiary care hospital. Patients demographic and clinical data were collected from request forms. Slides were reviewed and analyzed. Data were entered in microsoft excel and analyzed. Results: Out of total 110 cases analyzed, ratio of female to male is 3.07. There were 41.8% benign and 13.6% malignant cases. 42.7% were inflammatory and 1.9% congenital lesions (ectopic breast). The most common lesions encountered are from lymph node (51.8%) (lymphadenitis-most common) followed by soft tissue tumor (Lipoma – most common). Rare lesions include nonhodgkin lymphoma, hodgkin lymphoma, neurofibroma, and chondroid syringoma. Conclusion: FNAC is an outpatient-based accurate, rapid procedure helps in timely diagnosis of various axillary lesions including clinically and radiologically ambiguous cases. It also helps to discriminate benign and malignant lesions with less chances of false negative results.

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Bhattacharya, Auric, Madhumati Singh, Anjan Shah, and Lynn Lilly Varghese. "Partial superficial parotidectomy for pleomorphic adenoma of the parotid gland." BMJ Case Reports 14, no. 6 (June 2021): e238759. http://dx.doi.org/10.1136/bcr-2020-238759.

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Pleomorphic adenoma, otherwise called as benign mixed tumour, is the most common salivary gland tumour which accounts for 60% of all benign salivary gland tumours. The clinical, radiological and histopathological presentations are varied. The tumour occurs in diverse anatomical sites and can consist of epithelial and mesenchymal components. In this case report, the patient reported with an asymptomatic swelling on the face. CT scan with contrast was advised. The clinical, roentgenographic findings and Fine Needle Aspiration Cytology were indicative of pleomorphic adenoma of the parotid gland. Treatment included partial superficial parotidectomy under general anaesthesia using the modified Blair’s incision. The facial nerve was not involved. Part of the gland along with the tumour was resected completely superficial to the facial nerve with a margin of normal tissue all around. Histopathologic examination of tissue specimen confirmed the lesion as pleomorphic adenoma. The patient was asymptomatic at 6-month follow-up.

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Cavallini, Marco, Andrea Cecera, Antonio Ciardi, Salvatore Caterino, and Vincenzo Ziparo. "Small Periampullary Duodenal Gastrointestinal Stromal Tumor Treated by Local Excision: Report of a Case." Tumori Journal 91, no. 3 (May 2005): 264–66. http://dx.doi.org/10.1177/030089160509100311.

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Gastrointestinal stromal tumors (GIST) are mainly located in the stomach and the small bowel, with the duodenum accounting for about 4%. We report the case of a 66-year-old woman with a periampullary GIST of the duodenum that was treated by local excision and direct duodenal wall defect repair. Since no definitive clinical criteria have been established to differentiate malignant from benign mesenchymal tumors, preoperative cytology was not available and surgical removal of the 3.5 cm tumor was feasible, the patient was treated conservatively. The morbidity and mortality rates of the more radical and invasive duodenopancreatectomy, in particular when dealing with a soft pancreatic stump with a narrow pancreatic duct, are, in our opinion, too high for a potentially benign disease when the more conservative procedure is feasible. Four years after surgery the patient is doing well and control CT scan showed the absence of local recurrence.

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Stahl, Caleb, William G. Wong, Julie C. Fanburg-Smith, and Charles C. Vining. "Unsuspected gastric glomus tumour." BMJ Case Reports 16, no. 1 (January 2023): e253020. http://dx.doi.org/10.1136/bcr-2022-253020.

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Gastric glomus tumours (GGTs) are rare predominantly benign, mesenchymal neoplasms that commonly arise from the muscularis or submucosa of the gastric antrum and account for <1% of gastrointestinal soft-tissue tumours. Historically, GGT has been difficult to diagnose preoperatively due to the lack of unique clinical, endoscopic and CT features. We present a case of an incidentally identified GGT in an asymptomatic man that was initially considered a neuroendocrine tumour (NET) by preoperative fine-needle aspiration biopsy with focal synaptophysin reactivity. An elective robotic distal gastrectomy and regional lymphadenectomy were performed. Postoperative review by pathology confirmed the diagnosis of GGT. GGTs should be considered by morphology as a differential diagnosis of gastric NET on cytology biopsy, especially if there is focal synaptophysin reactivity. Additional staining for SMA and BRAF, if atypical/malignant, can help with this distinction. Providers should be aware of the biological behaviour and treatment of GGTs.

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Handa, Uma, Niti Singhal, Rajpal Singh Punia, Sudhir Garg, and Harsh Mohan. "Cytologic Features and Differential Diagnosis in a Case of Extraskeletal Mesenchymal Chondrosarcoma." Acta Cytologica 53, no. 6 (2009): 704–6. http://dx.doi.org/10.1159/000325415.

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Monappa, V., A. M. Naik, M. Mathew, L. Rao, S. K. Rao, L. Ramachandra, and J. PadmaPriya. "Phosphaturic mesenchymal tumour of the mandible - the useful criteria for a diagnosis on fine needle aspiration cytology." Cytopathology 25, no. 1 (December 2, 2012): 54–56. http://dx.doi.org/10.1111/cyt.12030.

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Marcinek, Mateusz, Konrad Majcherczyk, Marcel Nowak, Aleksander Targoński, and Michał Tkocz. "Solitary Fibrous Tumor of the Retroperitoneal Space." Case Reports in Surgery 2021 (January 9, 2021): 1–4. http://dx.doi.org/10.1155/2021/8857274.

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A solitary fibrous tumor develops from mesenchymal cells as a pleural neoplasm, but it is also occasionally reported in extrapleural sites. Retroperitoneal tumors are a group of neoplasms located between muscles and the fascia of the posterior abdominal wall and the parietal peritoneum. Their cytology differs from that of urinary tract organs or adrenals. This case report presents a rare solitary fibrous tumor incidentally found during an ultrasound examination. A 54-year-old male underwent urgent surgery for a tumor located in the left retroperitoneal space. The histologic examination confirmed a solitary fibrous tumor with a 5% Ki67 proliferation index, a 1 MF/10 HPF mitotic activity, and CD34-positive immunostains. A solitary fibrous tumor is a rare retroperitoneal tumor. Its symptoms and signs might resemble those of the classical triad of renal cell carcinoma, although the tumor’s growth phase is typically asymptomatic. Intraoperative diagnosis of a solitary fibrous tumor strongly recommends radical excision.

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Journal articles on the topic 'Mesenchyme Cytology'

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