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Journal articles on the topic 'Mesenchimali'

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Author: Grafiati

Published: 9 March 2023

Last updated: 10 March 2023

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1

Albisetti, W., L. Pedretti, M. Meda, O. De Bartolomeo, A. Corradi, and G. Mineo. "Le cellule mesenchimali." Archivio di Ortopedia e Reumatologia 120, no. 3-4 (November 2009): 15–17. http://dx.doi.org/10.1007/s10261-009-0043-6.

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2

Rizzo, Maria, Luigi Romano, and Nicola Tammaro. "Le cellule staminali mesenchimali nel trattamento delle pseudoartrosi." LO SCALPELLO-OTODI Educational 33, no. 3 (September 13, 2019): 270–74. http://dx.doi.org/10.1007/s11639-019-00328-w.

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3

Pellegrino, A., N. Tammaro, M. Conte, L. Romano, and S. Misso. "Il prelievo delle cellule staminali mesenchimali dalla cresta iliaca." LO SCALPELLO-OTODI Educational 33, no. 3 (September 12, 2019): 243–52. http://dx.doi.org/10.1007/s11639-019-00335-x.

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4

Battaglini, G., F. Guadalascara, and G. Monteleone. "Il prelievo delle cellule staminali mesenchimali dal tessuto adiposo." LO SCALPELLO-OTODI Educational 33, no. 3 (September 13, 2019): 253–57. http://dx.doi.org/10.1007/s11639-019-00342-y.

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5

Di Stefano, Danilo Alessio. "Rigenerazione dell’osso alveolare mediante l’utilizzo di cellule staminali mesenchimali adulte." Italian Oral Surgery 11, no. 1 (February 2012): 1–3. http://dx.doi.org/10.1016/j.ios.2011.11.001.

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6

Toro, G., L. Prinzo, M. Gison, C. Di Fino, A. De Cicco, A. Braile, F. Lepore, A. Toro, and A. Schiavone Panni. "Innesti di cellule staminali mesenchimali nelle grandi perdite di sostanza." LO SCALPELLO-OTODI Educational 33, no. 3 (September 12, 2019): 258–63. http://dx.doi.org/10.1007/s11639-019-00331-1.

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7

Scotto di Luzio, A., S. Di Franco, F. Peluso, D. Riccardi, and A. P. D’Amato. "Le cellule staminali mesenchimali nel trattamento delle lesioni muscolo-tendinee." LO SCALPELLO-OTODI Educational 33, no. 3 (September 5, 2019): 275–83. http://dx.doi.org/10.1007/s11639-019-00332-0.

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8

Grazioli, A., G. Scaravilli, F. Di Maggio, G. Bove, M. Italiano, R. Pezone, and B. Di Maggio. "Le cellule staminali mesenchimali nel trattamento delle condropatie del ginocchio." LO SCALPELLO-OTODI Educational 33, no. 3 (October 17, 2019): 284–88. http://dx.doi.org/10.1007/s11639-019-00336-w.

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9

Masola, V., S. Granata, M. Proglio, G. Gambaro, A. Lupo, and G. Zaza. "Eparanasi: un nuovo biomarker di fibrosi e un potenziale target farmacologico per ridurre la progressione del danno renale cronico." Giornale di Clinica Nefrologica e Dialisi 24, no. 2 (January 26, 2018): 10–15. http://dx.doi.org/10.33393/gcnd.2012.1131.

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Il trattamento poli-farmacologico ha determinato, nel corso degli anni, un significativo rallentamento della progressione della malattia renale cronica verso lo stadio di uremia terminale, ma siamo ancora distanti dallo sviluppo di interventi terapeutici in grado di bloccare questo inesorabile e irreversibile processo. Studi clinico-patologici hanno chiaramente dimostrato che il principale elemento coinvolto nel danno renale è la fibrosi tubulo-interstiziale e che il meccanismo patogenetico alla base di questa condizione ha inizio in larga parte nel compartimento tubulare. In particolare, il processo di transizione epitelio-mesenchimale gioca un ruolo importante nella genesi del danno cronico. Durante questo processo, le cellule epiteliali tubulari subiscono un incremento significativo di markers di superficie di natura mesenchimale e, grazie al rimodellamento del citoscheletro e alla degradazione della membrana basale, sono in grado di migrare nell'interstizio dove svolgono un ruolo chiave nel processo patogenetico. In questo contesto, sembra avere un ruolo chiave l'enzima eparanasi, una endo-β-D-glucuronidasi che taglia le catene dell'eparan-solfato a livello di siti specifici intracatena, e partecipa attivamente alla degradazione e al rimodellamento della matrice extracellulare. La degradazione dei vari costituenti dell'ECM, inclusi i proteoglicani eparan-solfato fa-vorisce il rilascio di fattori trofici quali il FGF-2 che induce l'espressione dei marcatori mesenchimali alfa-SMA, VIM e FN, porta alla degradazione della membrana basale mediante la secrezione di metalloproteinasi della matrice ed aumenta la motilità cellulare. L'epressione dell'eparanasi è regolata da fattori di trascrizione, dalla metilazione del DNA e da varie molecole endogene. L'importanza di questo enzima è stata confermata clinicamente dal riscontro di una sua iperespressione in preparati istologici di biopsie effettuate in soggetti affetti da nefropatie croniche (per esempio, nefropatia diabetica). Pertanto visto l'importante ruolo dell'eparanasi sono in fase di standardizzazione numerose strategie per inibire la sua espressione genica e/o la sua attività enzimatica. Infine, è stato proposto il suo possibile utilizzo come biomarker di progressione del danno tubulo-interstiziale da utilizzare routinariamente in ambito nefrologico.

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10

Donelli, A., M. De Mare, P. Gogna, C. Borrelli, and U. Repetto. "Due Casi di Tumori Mesenchimali a Cellule Muscolari del Funicolo Spermatico." Urologia Journal 71, no. 3 (July 2004): 267–68. http://dx.doi.org/10.1177/039156030407100323.

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11

Buda, R., F. Vannini, M. Cavallo, D. Luciani, M. Baldassarri, A. Olivieri, and S. Giannini. "Mesenchimali e patologia condrale e osteocondrale del ginocchio: indicazioni e risultati." Archivio di Ortopedia e Reumatologia 124, no. 1-3 (December 2013): 39–41. http://dx.doi.org/10.1007/s10261-013-0058-x.

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12

Capuano, Nicola, Flavio Carbone, Guido Grillo, and Alessio D’Addona. "Cellule staminali mesenchimali associate a core-decompression nel trattamento delle necrosi cefaliche." LO SCALPELLO-OTODI Educational 33, no. 3 (September 13, 2019): 264–69. http://dx.doi.org/10.1007/s11639-019-00340-0.

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13

Cortese, Fabrizio, Leonardo Puddu, Domenico Mercurio, and Alessandro Santandrea. "Innesto di cellule mesenchimali su membrana nel trattamento delle patologie cartilaginee della tibio-tarsica." LO SCALPELLO-OTODI Educational 33, no. 3 (October 25, 2019): 304–10. http://dx.doi.org/10.1007/s11639-019-00341-z.

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14

Gobbi, A. "L’impiego delle cellule mesenchimali autologhe e del gel piastrinico per il trattamento delle lesioni cartilaginee." Archivio di Ortopedia e Reumatologia 120, no. 3-4 (November 2009): 29–31. http://dx.doi.org/10.1007/s10261-009-0049-0.

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15

Leonida, A., A. Paiusco, G. Rossi, F. Carini, and M. Baldoni. "Effetti della low-level laser irradiation su cellule staminali mesenchimali inoculate in una biomatrice tridimensionale: studio pilota in vitro." Italian Oral Surgery 11, no. 3 (June 2012): 96–104. http://dx.doi.org/10.1016/j.ios.2011.03.002.

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16

Delnegro, Eleonora Liliana, Viviana Desantis, Camilla Elli, Marta Grendele, and Alberto Pispero. "Lipoma orale: neoplasia mesenchimale benigna." Dental Cadmos 91, no. 03 (February 2023): 175. http://dx.doi.org/10.19256/d.cadmos.03.2023.03.

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17

Pasi, Cristina E., and Pier Giuseppe Pelicci. "Inhibition of epithelial-to-mesenchimal transition." Cell Cycle 10, no. 16 (August 15, 2011): 2616. http://dx.doi.org/10.4161/cc.10.16.16543.

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18

Sesti, Franz, and Antongiulio Faggiano. "Amartoma mesenchimale del fegato e Sindrome DICER1." L'Endocrinologo 20, no. 4 (July 24, 2019): 252–53. http://dx.doi.org/10.1007/s40619-019-00605-1.

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19

Alempijevic, Tamara, M. Spuran, Srdan Djuranovic, Nada Kovacevic, Milos Popovic, and Vesna Cemerikic-Martinovic. "Gastrointestinal stromal tumor of small intestine: Case report." Acta chirurgica Iugoslavica 51, no. 3 (2004): 133–36. http://dx.doi.org/10.2298/aci0403133a.

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Gastrointestinal stromal tumor is a form of mesenchimal neoplasm that may be present in all parts of gastrointestinal system. We are reviewing diagnostic and therapeutic algorithms for patient with diagnosed gastrointestinal neoplasm of small intestine, experiencing repeated episodes of painful bleeding from gastrointestinal trackt.

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20

Klimovich, V. B. "IMMUNOMODULATORY ACTIVITY OF MESENCHIMAL STROMAL (STEM) CELLS." Medical Immunology (Russia) 16, no. 2 (August 1, 2014): 107. http://dx.doi.org/10.15789/1563-0625-2014-2-107-126.

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21

Knyazev, O. V., A. G. Konoplyannikov, A. I. Parfenov, I. N. Ruchkina, A. A. Churikova, E. A. Albulova, S. V. Bykova, et al. "THE SAFETY OF MESENCHIMAL STROMAL CELLS THERAPY." Journal of Clinical Practice 5, no. 3 (September 15, 2014): 5–14. http://dx.doi.org/10.17816/clinpract535-14.

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There is a large amount of literature data that shows the effectiveness of cell therapy using mesenchymal stromal cells (MSCs), as on preclinical models and in some clinical studies in small groups of patients.Currently the use of MSC in clinical practice is limited by security considerations. Potential risks associated with their proliferative capacity, the risk of infectious complications, as well as the possible immunogenicity of the cells themselves.Foreign researchers analyzed on the basis of a literature review, the results of which evaluated the clinical safety of MSCs. The article presents the results of our monitoring of patients with inflammatory bowel disease (IBD), which received MSCs in the Department of pathology bowel. The results of our study, and the results, given in the review, should provide scientists and policy-makers the confidence that according to available scientific data an innovative method of cell therapy is safe for clinical use.

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22

Zlatska, A. V. "ISOLATION OF MULTIPOTENT MESENCHIMAL STROMAL CELLS FROM MINIMAL HUMAN ENDOMETRIUM BIOPSY." Biotechnologia Acta 11, no. 1 (February 2018): 76–81. http://dx.doi.org/10.15407/biotech11.01.076.

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23

Daolio, P. A., S. Bastoni, M. Ferraro, F. Lazzaro, P. Zacconi, R. Zorzi, S. Mapelli, S. Casari, and M. Laccisaglia. "Fratture patologiche in paziente con tumore mesenchimale fosfaturico." Archivio di Ortopedia e Reumatologia 121, no. 2-3 (November 2010): 32–33. http://dx.doi.org/10.1007/s10261-010-0035-6.

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24

Jovovic, M., P. Bajic, M. Golubovic, V. Dobricanin, and I. Maric. "Massive GIST of the stomach: Case report." Acta chirurgica Iugoslavica 54, no. 2 (2007): 127–29. http://dx.doi.org/10.2298/aci0702127j.

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Gastrointestinal stromal tumors (GIST) are rare mesenchimal neoplasmas of the gastrointestinal tract. The diagnosis of this tumors are often very difficult. Patients with this tumor are usually admitted to the hospital cause of the gastrointestinal bleeding, abdominal pain, abdominal distension, dysphagia, obstructive jaundice and bowel obstruction. In this case report, we present a 86 year old patient with massive GIST of the stomach which was not preoperatively diagnosed. .

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25

Kamalov, A. K., A. B. Ryabov, V. M. Khomyakov, N. N. Volchenko, I. V. Kolobaev, A. K. Kostrygin, and S. A. Aksenov. "Method for laparoscopic transgastral resection for mesenchimal gastric tumors." Siberian journal of oncology 21, no. 1 (March 3, 2022): 151–56. http://dx.doi.org/10.21294/1814-4861-2022-21-1-151-156.

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The purpose of the study was to evaluate the efficacy and safety of laparoscopic transgastric resection for mesenchymal tumors of the proximal stomach.Material and Methods. A retrospective-prospective study was carried out. Surgical techniques of laparoscopic transgastric resection and the history of the development of this surgical method were described in detail. A total of 11 laparoscopic transgastric resections were performed. The course of the postoperative period and the postoperative management of patients were described. The immediate and long-term results of surgical treatment and the quality of life of patients were presented.Results. The assessment of the quality of life of patients after surgery showed that there were no cases of gastroesophageal reflux disease compared to proximal subtotal resection of the stomach or endoscopic tunnel resection. All patients underwent radical resection. In our study, we did not encounter cases of conversion of the surgical approach, as well as serious postoperative complications (Clavien–Dindo>III ). The analysis of long-term treatment outcomes showed that there were no cases of recurrence or disease progression. All patients are alive and followed up.Conclusion. This technique is fully justified, with careful selection of patients and compliance with all the rules of surgical oncology. Transgastric resection of gastric mesenchymal tumors located in the region of the cardioesophageal junction is a justified and safe technique. Surgery is performed under clear visual control, EGDS is not required to detect the tumor. This method allows the reduction of the frequency of contamination of the gastric flora into the abdominal cavity as well as the reduction of the wound area of the anterior abdominal wall.

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26

Fibbe, W. "OP35 Modulation of immune responses by mesenchimal stem cells." Leukemia Research 31 (September 2007): S48—S49. http://dx.doi.org/10.1016/s0145-2126(07)70315-6.

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27

Makarevich, Sergej, Andrej Мazurenka, Kirill Krivorot, Andrej Malashenko, Мichael Potapnev, Svetlana Kosmacheva, Nataliya Danilkovich, and Alexandra Ionova. "Application of autological mesenchimal stem cells for the spondylodese purpose." Science and Innovations 11, no. 201 (November 2019): 79–84. http://dx.doi.org/10.29235/1818-9857-2019-11-79-84.

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28

Conticello, Concetta, Raffaella Giuffrida, Luana Adamo, Gabriele Anastasi, Gioacchin Iannolo, Edvige Salomone, Lorenzo Memeo, et al. "NF-Kb Localization in Multiple Myeloma Plasmacells and Mesenchimal Cells." Blood 112, no. 11 (November 16, 2008): 5149. http://dx.doi.org/10.1182/blood.v112.11.5149.5149.

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Abstract Several reports have clearly demonstrated that the activation of Nuclear factor-kappa B (NF-kB) is essential for the pathogenesis of MM because it regulates the expression of many proteins involved in cell survival, proliferation, and resistance to chemotherapeutic drugs. We therefore analyzed by immunohistochemistry, immunofluorescence and western blot analysis the nuclear localization of NF-κB in MM cells derived from 60 different patients with MM at presentation and in relapse, as well as in three myeloma cell lines (XG1, RPMI 8226, KMS-18). Surprisingly, nuclear localization (the active form) of NF-κB was detected in only one MM sample from a refractory MM patient and in two samples from relapsed patients, while all the other samples, including the MM cell lines, exclusively express the cytoplasmic (inactive) form of NF-κB. We next analyzed the NF-κB status in mesenchymal cells from MM patients and we found that NF-κB was clearly present in the nucleus. We have also analyzed the sensitivity of MM primary cells to different doses of the proteasome inhibitor Bortezomib, which is described to antagonize NF-κB activity. We found a consistent dose- and time-dependent antitumor activity against both chemoresistant and chemosensitive myeloma cells in all the samples analyzed, independently of NF-κB localization. In conclusion, contrary to the current dogma that indicates a constitutive activation of NF-kB in MM cells, we demonstrated that in a steady state, especially in patients at diagnosis, NF-kB resides in the cytoplasm (the inactive form) but the cells maintain the sensitivity to Bortezomib, thus indicating that block of IkB degradation is not the only mechanism responsible for proteasome inhibitor induced-apoptosis.

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29

Volotovski, I. D. "Resident and progenitor stem cells of the heart: morphology and f unction properties and prospects for practical application." Proceedings of the National Academy of Sciences of Belarus, Biological Series 64, no. 4 (November 7, 2019): 499–512. http://dx.doi.org/10.29235/1029-8940-2019-64-4-499-512.

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The analysis of literature data on one of the actual problem of modern cell biophysics and biotechnology dealing with mesenchimal stem cells and cordial progenitor cells taking part in reparation of myocardium after its injury and first of all after myocardial infarction was done. Biological properties and potential ability of these cells in reparation processes of myocardium are considered. The recent data on experiments using experimental animals and patients are given. The approaches to increase the efficacy of сell technologies in treatment of injured cardiomyocytes are discussed.

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30

Latincic, Stojan, Natasa Colovic, Marjan Micev, and Radoje Colovic. "Pendular stromal tumour of the stomach with dominant PDGFRA immunoexpression: Case report and short literature review." Srpski arhiv za celokupno lekarstvo 140, no. 3-4 (2012): 216–20. http://dx.doi.org/10.2298/sarh1204216l.

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Introduction. Gastrointestinal stromal tumours are most frequent mesenchimal tumours of the gastrointestinal tract that originate from Cajal?s interstitial cells that are most frequently CD-117 positive. Stromal tumours of the stomach are the most frequent mesenchimal tumours of the gastrointestinal tract. Such tumours are usually sessile, but rarely pendular when they can be easily removed with a limited local excision of the stomach wall around the pedicle. Major stomach resections are rarely necessary. Case Outline. In a 54-year-old woman with abdominal pain and fever of unknown aetiology, a large spherical mobile and almost painless mass was found within the upper right abdomen. US and CT showed a mainly cystic, partly solid tumour, of 15.5?12.5 cm in diameters. Laboratory data including tumour markers were within normal limits. At operation a mobile and free tumour of the stomach attached to the anterior wall with a 2.5 cm pedicle was found and easily excised. Abdominal mucosa was normal. There was no liver metastasis or peritoneal dissemination. Hystology and imunohistochemistry showed a rare sclerosing sincitial subtype of stromal tumour with imunophenotype heterogenicity with a dominant PDGFRA and rare CD-117 immunoexpression. The postoperative recovery was uneventful. The patient was symptom-free with no sign of recurrence after a year and a half. Conclusion. A rare subtype of histological highly malignant stromal tumour of the stomach, macroscopically of pendular type, that was easily excised, was presented which so far showed a favourable evolution with no signs of recurrence.

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31

Goldberg, Ye D., A. M. Dygai, and V. V. Zhdanov. "The role of stem cells in the recovery of hemopoiesis in cytostatic and radial myelosuppressions." Bulletin of Siberian Medicine 5, no. 2 (June 30, 2006): 35–42. http://dx.doi.org/10.20538/1682-0363-2006-2-35-42.

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The development of hemopoietic tissue hypoplasia and recovery of hemopoietic dynamics in addition to the direct suppressive effect of toxic agents on hemopoietic cells are mainly due to the character of hemopoietic disregulation were shown on different models of myelosuppressions (irradiation, injecting cytostatic drugs having different action mechanisms). At the same time, compensatory changes of blood system and underlying mechanisms are mainly non-specific and of the same type. Creation of reparative processes in the hemopoietic tissue is significantly by bone marrow stromal cells thanks to chemioand radioresistance of their precursors (mesenchimal stem cells).

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32

Goldberg, Ye D., A. M. Dygai, and G. N. Zyuz’Kov. "Blood system regulation mechanisms in oxygen insufficiency and participation of neural stem cells in the adaptation to hypoxia." Bulletin of Siberian Medicine 5, no. 2 (June 30, 2006): 43–51. http://dx.doi.org/10.20538/1682-0363-2006-2-43-51.

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Large-scale study of regulation and disadaptation mechanisms of blood system in hypoxia of different genesis is performed. Negative influence of encephalopathy and associated with it adrenergic system activation on hemopoiesis is shown which manifests in disturbed erythropoiesis and production of pathologic forms of erythrocytes. Participation of bone marrow mesenchimal stem cells and increased content of neural cells-precursors in central nervous system in conditions of oxygen deficiency are revealed. Failure of the given adaptation mechanisms of “deep reserve” in severe hypoxia which manifests in the development of encephalopathy and disadaptation of hemopoietic tissue is revealed.

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33

Lavrishcheva, G. I. "Results of Investigation of Theoretical Problems of Reparative Regeneration of Loco-Motor 58 System." N.N. Priorov Journal of Traumatology and Orthopedics 3, no. 3 (September 15, 1996): 58–61. http://dx.doi.org/10.17816/vto102933.

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Results of investigations of the restorative processes in loco-motor system injuries are generalized. These investigations performed at the Department of Pathologic Anatomy of CITO from 1930s to 1980s included about 10000 experimental studies (2000 observations) and joint study with traumatologists, orthopaedic and plastic surgeons. Possibility of organotopic regeneration of limbs for the account of mesenchimal resource - skeletogenous tissue is emphasized. However such an outcome of the reparative regeration is possible only under strictly definite conditions created by the surgeon that are specific for different tissues (cartilage, bone, tendon) and in different types of their injury. Some conditions have been formulated for the first time.

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34

Sergeevichev, D. S., V. V. Sergeevicheva, A. I. Subbotovskaya, Ya L. Rusakova, N. A. Podkhvatilina, and V. Yu Vasilev. "Toxic influence of detergents on human mesenchimal stromal cells during graft repopulation." Patologiya krovoobrashcheniya i kardiokhirurgiya 17, no. 2 (October 10, 2015): 67. http://dx.doi.org/10.21688/1681-3472-2013-2-67-71.

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Detergents are effective decellularization agents in order to obtain cell-free matrixes. However, the toxicity of residual detergent prevents the adhesion of cells to the matrix and the realization of their functions. In this study, the degree of influence of residual detergents on mesenchymal stromal cells after a series of washes was investigated. The human pulmonary valve were treated in three ways: 1% solution of sodium dodecyl sulfate, 1% solution of sodium deoxycholate and a combination of these solutions with the reduction of the concentration to 0.5%. After each of 8 steps washing buffer were collected. We investigated influence of residual detergents on cytotoxicity and effect on the metabolic activity of MSCs. Histologic analysis showed sufficient tissue decellularization in all groups. Matrixes were washed by successive incubations with 200 ml of phosphate buffer. Detergent concentrations in all samples ceased to be toxic only to the 4-cycle wash, and had no effect on the metabolism and viability of human MSCs. After 4-8 washing cycles decellularized pulmonary trunk fragments were successfully settled by mesenchymal stromal cells. Thus, a few successive washing fabrics pulmonary valve after decellularization reduce residual detergent to a safe level and lead to successful repopulation of acellular scaffolds with MSCs.

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35

Baldueva, Irina, Tatyana Nekhaeva, and Aleksei Belyaev. "Mesenchimal stem cells in treatment of cancer patients with COVID-19 pneumonia." Problems in oncology 67, no. 1 (March 4, 2021): 7–12. http://dx.doi.org/10.37469/0507-3758-2021-67-1-7-12.

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The review discusses the pathogenetic mechanisms of the development of respiratory infection COVID-19 and the clinical use of cell technologies based on mesenchymal stem cells (MSCs). Due to the global pandemic of COVID-19/SARS-CoV-2 respiratory infection associated with the spread of the SARS-CoV-2 virus, and the difficulty in treating severe cases of infection, the immunomodulatory activity of MSCs due to inflammatory microenvironment factors can be used in the complex treatment of COVID-19 pneumonia, including in cancer patients.

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36

Kovalchuk, M. V., N. S. Shuvalova, and V. A. Kordium. "Peculiarities of the metabolic activity of mesenchimal stem cells under oxidative stress." Faktori eksperimental'noi evolucii organizmiv 26 (September 1, 2020): 212–16. http://dx.doi.org/10.7124/feeo.v26.1268.

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Aim. Oxidative stress is considered to be one of the major damaging factors that limits the therapeutic potential of mesenchymal stem cells (MSCs). The purpose of our work was to study the metabolic activity of Wharton jelly-derived MSC of different donor origin under oxidative stress conditions induced by hydrogen peroxide. Methods. MSC were obtained by the explant method and cultured according to standard methods. Oxidative stress was caused by treating cells with different concentrations of hydrogen peroxide. The metabolic activity of MSCs was evaluated using the MTT test. Results. Analysis of the MTT test showed a biphasic dependence of the MSC response to the concentration of H2O2. Concentrations of hydrogen peroxide from 6.25 to 50 μM increased the level of metabolic activity of MSCs, and concentrations from 50 to 440 μM inhibited metabolic activity. The maximum stimulating effect was observed at concentrations of 12.5 μM and 25 μM depending on the donor. Conclusions. The response of cells to oxidative stress corresponded to the hormetic dependence, and the points of critical concentration and maximum stimulation were individual for each donor. Processes such as preconditioning MSCs with hydrogen peroxide to increase their survival rate during transplantation also require personalization of the approach depending on the points of maximum stimulation. Keywords: mesenchymal stem cells, hydrogen peroxide, oxidative stress.

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37

Emet, Samim. "Cardiac invasion of the intrabronchial malignant mesenchimal tumor from left pulmonary vein." Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology 42, no. 7 (2014): 688. http://dx.doi.org/10.5543/tkda.2014.96641.

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38

Radetskaya, L. S., A. D. Makatsariya, V. O. Bitsadze, and J. K. Khizroeva. "Pregnancy and mesenchimal dysplasias (Marfan syndrome, Ehlers-Danlos syndrome, hereditary hemorrhagic telangiectasia)." Journal of Maternal-Fetal & Neonatal Medicine 31, no. 13 (June 13, 2017): 1768–76. http://dx.doi.org/10.1080/14767058.2017.1326905.

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39

Seccia, Teresa M., and Lorenzo A. Calò. "Endothelin-1-induced endothelial mesenchimal transition via endothelin type B receptor stimulation." Journal of Hypertension 35, no. 6 (June 2017): 1329–30. http://dx.doi.org/10.1097/hjh.0000000000001344.

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Deev, R. V. "Cell transplantation for COVID-19 treatment: transmission of stem stomal (mesenchimal) cells." Genes & Cells 15, no. 2 (June 15, 2020): 10–19. http://dx.doi.org/10.23868/202004012.

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The review presents the modern concept of the pathogenesis of diffuse alveolar damage, including acute respiratory distress sYndrome in coronavirus infection. It has been established that the so-called "cytokine storm”, which consists in the increased release of substances that are biologically active against the vascular wall and effector cells, leading to the progressive damage to endotheliocytes and alveolocytes, the development of alveolar and interstitial pulmonary edema with fatal respiratory failure and coagulopathy. An important factor in interstitial aggression is the appearance of autoreactive clones of plasma cells, dissemination of virusinfected leucocytes throughout the body with the involvement of various organs and systems, which exacerbates multiple organ failure. A poor prognosis for patients, the likelihood of developing pulmonary fibrosis after infection, according to several researchers, can be corrected by cell therapy. Allogeneic multipotent mesenchymal stromal cells (mesenchymal stem cells) are considered as first-line therapeutic cells. The accumulated experience of preclinical experiments made it possible to urgently proceed to conduct clinical trials of the safety of their use in patients with ARDS and to search for optimal indications to obtain maximum benefits for patients after transplantation. The combined efforts of many research groups can lead to reliable information on the cell therapy benefit and the need to include it in the standards of treatment of patients with this extremely severe pathology.

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Stevanovic, Dejan, Vuk Aleksic, Dragos Stojanovic, Nebojsa Mitrovic, Damir Jasarovic, and Zorana Bokun-Vukasinovic. "Osseous metaplasia in an inflammatory polyp of the anal canal: A case report and a review of literature." Srpski arhiv za celokupno lekarstvo 147, no. 3-4 (2019): 211–14. http://dx.doi.org/10.2298/sarh180312037s.

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Introduction. Osseous metaplasia is a heterotopic formation of bone and its appearance in benign gastrointestinal polyps is exceedingly rare. The mechanism responsible for this type of metaplasia is not fully understood, however it seems to be an innocent rare phenomenon. Case outline. We present a case of a 31-year-old male with mesenchimal osseal metaplasia in a large inflamatory polyp measuring 57 ? 23 ? 20 mm in diameter, located in the anal canal region. Conclusion. According to our knowledge, this is the largest gastrointestinal polyp with osseous metaplasia described so far. Although a rare phenomenon, there are certain characteristics of this disease, so we conducted a literature review and summarized these characteristics.

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Goktug, Goksel Hasan, Ufuk Ozturk, Nevzat Can Sener, Can Tuygun, Hasan Bakirtas, and Abdurrahim Muhammet Imamoglu. "Transurethral resection of a bladder leiomyoma: A case report." Canadian Urological Association Journal 8, no. 1-2 (February 12, 2014): 111. http://dx.doi.org/10.5489/cuaj.1335.

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Benign mesenchimal tumour of the human bladder is rare. Insulin potentiation therapy mimics malignant tumours both clinically and radiologically. We present a patient we treated with transurethral resection (TUR) only. A 27-year old male patient presented to our clinic with frequency, dysuria and recurrent urinary tract infections. Magnetic resonance (MRI) revealed an endovesical bladder mass of 7 × 8 cm. We performed TUR in the same session for both diagnosis and treatment. The diagnosis was endovesical leiomyoma. Six months to a year after the operation, the MRI did not reveal disease recurrence. Even though TUR is recommended for smaller and endovesical tumours, we believe larger intravesical tumours may also be managed by TUR.

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Kotovschikova, Ye F., Ye I. Buyevich, V. P. Kulikov, V. F. Chudimov, and Ye Pen’kova. "Genetic polymorphism of haemostatic system in patients with venous disfunction at mesenchimal dysplasia." Bulletin of Siberian Medicine 7 (December 30, 2008): 64–65. http://dx.doi.org/10.20538/1682-0363-2008-0-64-65.

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Sretenovic, A. Lj, Z. D. Krstic, D. R. Vujovic, P. K. Pavicevic, and N. D. Janic. "Cystic mesenchimal hamartoma of the liver in two years old patient: Case report." Acta chirurgica Iugoslavica 57, no. 2 (2010): 103–5. http://dx.doi.org/10.2298/aci1002103s.

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Mesenchymal hamartoma is an uncommon benign hepatic tumor arising from the mesenchyme of the portal triad. This lesion is relatively uncommon, representing 5% of all primary hepatic pediatric tumors. This form of hamartoma usually presents before the age of 2 years, typically with abdominal swelling as theinitial symptom. The classic management of these lesions has been excision either by hepatic lobectomy or wedge resection. We present a case of 2 years old girl with a right hepatic lobe tumor, 66 x 57 x 71 in diameter that was completely removed by right hepatic lobectomy.

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Perrotta, F. M., G. Guerra, A. De Socio, S. Scriffignano, and E. Lubrano. "Mesenchimal stem cells: a possible role in the pathogenesis and treatment of spondyloarthritis." Reumatismo 69, no. 1 (May 22, 2017): 1. http://dx.doi.org/10.4081/reumatismo.2017.976.

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Spondyloarthritis (SpAs) are a group of chronic inflammatory diseases that affect joints and enthesis with a possible involvement of other districts such as skin, eye and bowel. In SpAs, the inflammatory process could lead to both erosive damage (as in peripheral joint involvement of psoriatic arthritis), or bone formation (as in ankylosing spondylitis) with a reduction in function and quality of life. Recently, Mesenchimal stem cells (MSCs) transplant was used in different diseases, including autoimmune and inflammatory diseases, with the aim of repairing tissue damage, exploiting their regenerative capacity. However, MSCs also proved to have an immune-modulatory capacity due to their interaction with the cells of the immune system. The aim of this brief paper was to review the possible pathogenic role and the new perspective of MSCs use in SpAs.

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Volotovski, I. D., S. V. Pinchuk, and I. B. Vasilevich. "Transcription factors – key regulatory biomolecules determining the differentiation of mesenchimal stem cells into the somatic cells of organs and tissues." Proceedings of the National Academy of Sciences of Belarus, Biological Series 67, no. 3 (August 4, 2022): 309–20. http://dx.doi.org/10.29235/1029-8940-2022-67-3-309-320.

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Тhe mechanisms of differentiation of mesenchimal stem cells into the somatic cells of organs and tissues underlying embryogenesis and natural reparation processes and providing the structural and functional homeostasis of cells are considered. The data on adipogenic, osteogenic, chondrogenic, miogenic, and endothelial differentiations are given, which results in the formation of the cells of mesodermal origin in organism. The problem is discussed, how the transcription factors control each type of differentiation and participatе in them using various regulatory biomolecules, transcription factors, cytokines, and chimokins being in complicate permanent interactions and forming the integrity regulatory network. The participation in differentiation processes of a number of transcription factors (Runx2, Sox9, PPARγ, MyoD, GATA4 и GATA6) is discussed, the expression of which is under a permanent chemical control within the cellular regulatory network.

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Philchenkov, A. A. "Bone marrow adipocytes and multiple myeloma." Oncohematology 14, no. 1 (April 10, 2019): 60–75. http://dx.doi.org/10.17650/1818-8346-2019-14-1-60-75.

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Multiple myeloma originating from clonal proliferation of plasma cells in the bone marrow is one of the most prevalent hematological malignancies worldwide. The pathogenetic mechanisms of multiple myeloma are far from being elucidated. Nevertheless, it is known that the adipocytes as the prevalent cellular component of bone marrow microenvironment contribute significantly to multiple myeloma growth and progression. The review discloses the recent data on the interactions between bone marrow adipocytes and myeloma cells, hematopoietic stemcells, hematopoietic progenitor cells, mesenchimal stem cells, osteoblasts, osteoclasts, endothelial cells, and cells of immune system. Also, the review places special emphasis on bone marrow adipocyte-produced adipokines, growth factors, cytokines, chemokines, and fatty acids providing the conditions for the preferential growth and migration of malignant plasma cells and contributing to hematopoiesis supression, bone tissue resorption, angiogenesis activation and immunosuppression.

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Landi, Elena, Anna Tampieri, Gian Carlo Celotti, Monica Mattioli-Belmonte, and Giandomenico Logroscino. "Synthetic Biomimetic Nanostructured Hydroxyapatite." Key Engineering Materials 284-286 (April 2005): 949–52. http://dx.doi.org/10.4028/www.scientific.net/kem.284-286.949.

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The incorporation of magnesium ions into the hydroxyapatite structure, which is of great interest for the developing of artificial bone, was performed starting from a wet chemical synthesis using magnesium chloride as Mg source. Different doping extents were attempted, four powders were produced and characterized in term of morphology, composition, solubility, thermal resistance,etc. in comparison with stoichiometric HA. In vitro tests with mesenchimal stem cells (MSCs) and human osteoblast like cells MG-63 cells were performed with the powder characterized with a biological-like doping of 5%Mg. The same powder was used, in form of granules, to carry out in vivo test by filling a defect in the femur on New Zealand White rabbits. All the tests showed better performance of the Mg doped apatite compared to stoichiometric HA, in agreement with the chemico-physical features of the material.

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Shubin, V. P., Yu A. Shelygin, O. I. Sushkov, and A. S. Tsukanov. "THE ROLE OF THE EPITHELIALLY-MESENCHIMAL TRANSITION IN THE DEVELOPMENT OF COLORECTAL CANCER (review)." Koloproktologia, no. 2 (June 30, 2018): 111–17. http://dx.doi.org/10.33878/2073-7556-2018-0-2-111-117.

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Demianenko, Elena V., Aleksandr I. Glukhov, and Galina K. Gryzunova. "Effect of Mesenchimal Stem Cells on Apoptosis Indices in Renal Parenchyma during Experimental Stress." Acta Biomedica Scientifica 4, no. 1 (April 4, 2019): 138–42. http://dx.doi.org/10.29413/abs.2019-4.1.21.

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Background.Kidneys are extremely sensitive to various environmental factors. Stress disturbs prooxidant-antioxidant balance, causes hyperproduction of reactive oxygen species, changes activity of the nitroxidergic system components, regulating apoptosis. The use of mesenchymal stem cells can normalize functioning of damaged organs in the pathological process.Aim:to assess the effectiveness of mesenchymal stem cells in a single 24-hour immobilization according to the dynamics of apoptosis indices in renal tissue – nitric oxide (NO) and fragmented DNA.Materials and methods.The study included male nonlinear white rats aged 3 to 4 months and weighing 225 ± 25 grams. Experimental stress was modeled by the immobilization of animals in the fixation chambers within 24 hours. The efficacy of cell therapy was determined by the change in the concentration of the tested substances at 1, 3, 7, 14, 21 and 30 days of the experiment.Results.There was a sharp increase in the total amount of nitrates / nitrites and the level of DNA fragmentation in the homogenates of the renal parenchyma after the action of an acute stressor, which may indicate the induction of apoptosis. It was proved that in animals, receiving mesenchymal stem cells as a treatment, the restoration of the studied parameters in the kidney tissue was significantly accelerated in comparison with the controls values.Conclusion.Mesenchymal stem cells protect cells from self-destruction and activate reparation, which makes them promising for further study.

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