Journal articles: 'Mental Chemotherapy'

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Meymandi, Assad. "Mental Exercises Counter Chemotherapy." Psychiatric News 42, no. 7 (April 6, 2007): 27. http://dx.doi.org/10.1176/pn.42.7.0027.

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Redd, William H., Mark R. Dadds, Ann D. Futterman, Kathryn L. Taylor, and Dana H. Bovbjerg. "Nausea induced by mental images of chemotherapy." Cancer 72, no. 2 (July 15, 1993): 629–36. http://dx.doi.org/10.1002/1097-0142(19930715)72:2<629::aid-cncr2820720249>3.0.co;2-7.

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Anand, Ajay, William H. Redd, Mark R. Dadds, Ann D. Futterman, Kathryn L. Taylor, and Dana H. Bovbjerg. "Nausea induced by mental images of chemotherapy." Cancer 73, no. 3 (February 1, 1994): 755–56. http://dx.doi.org/10.1002/1097-0142(19940201)73:3<755::aid-cncr2820730344>3.0.co;2-r.

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Sengar, Vaishali. "Topical Dosage for Treatment of Chemotherapy- Induced Peripheral Neuropathy." International Journal of Psychosocial Rehabilitation 23, no. 4 (December 30, 2019): 1766–78. http://dx.doi.org/10.37200/ijpr/v23i4/pr190507.

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Knudsen, Peder. "Chemotherapy With Neuroleptics." Acta Psychiatrica Scandinavica 72, S322 (July 1985): 51–75. http://dx.doi.org/10.1111/j.1600-0447.1985.tb08540.x.

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Brandão, D., T. Assunção, and H. Almeida. "Invisible Effects of Chemotherapy." European Psychiatry 41, S1 (April 2017): S668. http://dx.doi.org/10.1016/j.eurpsy.2017.01.1138.

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IntroductionChemotherapy is an essential component in the treatment and alleviation of oncological diseases. To your application are associated, as well as systemic effects, cognitive impairment in patients. These changes have received increasing attention due to the impact on quality of life of cancer survivors.ObjectivesThis study aims to evaluate the current evidence on the association between chemotherapy and cognitive impairment in cancer patients, especially in the areas affected cognitive function, possible mechanisms of action and consequences on the quality of life of these patients and the importance of identifying strategies intervention in order to minimize these effects.MethodsWe conducted a literature review from literature articles addressing this topic with use of databases: Medline and Pubmed. The following keywords were used: “chemobrain”, “cognitive dysfunction”, “chemotherapy”.ResultsAlthough some states have not found differences, several studies have shown that chemotherapy has implications cognitively. Underlying etiology remains unknown, and proposed several mechanisms to explain these changes: neurotoxicity, microvascular damage and inflamamatory response. Cognitive impairment has significant implications in the daily life of patients both personally, socially and labour. The therapeutic approach focuses on the patient and family education, coping strategies, cognitive rehabilitation and cognitive behavioural therapy.ConclusionsIt is vital to educate patients about the possibility of cognitive change as effect of chemotherapy as well as health professionals in the early identification of these changes. It is essential developing specific intervention strategies to improve the quality of life of the oncologic patient during and after treatment.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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Deleemans, Julie M., Kirsti Toivonen, Raylene A. Reimer, and Linda E. Carlson. "The Chemo-Gut Study: A Cross-Sectional Survey Exploring Physical, Mental, and Gastrointestinal Health Outcomes in Cancer Survivors." Global Advances in Health and Medicine 11 (January 2022): 2164957X2211459. http://dx.doi.org/10.1177/2164957x221145940.

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Background Cancer treatments, such as chemotherapy, may adversely affect gastrointestinal (GI), physical and mental health in survivors of cancer. Objective This study investigated associations between GI, mental and physical health outcomes, and cancer treatment-related variables, such as chemotherapy, in adult cancer survivors. Methods A one-time cross-sectional survey with patient-reported outcomes was used. Cancer survivors (N = 317) aged ≥18 years, living in Canada, who completed cancer treatments were included. Descriptive statistics, correlation, and linear regression analyses are reported. Results Mean age at diagnosis was 40.90 ± 15.40 years. Most survivors received chemotherapy (86.1%). Persistent GI symptoms include constipation (53.6%), diarrhea (50.5%), and bloating/pain (54.9%). Mean GI symptom duration was 30.53 ± 33.42 months. Severity of GI symptom interference was moderate to extreme for 51.9% of survivors. Compared to normative values of 50 in healthy people, survivors scored poorer for mental health (M = 42.72 ± 8.16) and physical health (M = 45.55 ± 7.93), and reported more belly pain (M = 56.10 ± 8.58), constipation (M = 54.38 ± 6.81), diarrhea (M = 55.69 ± 6.77), and gas/bloating (M = 56.08 ± 8.12). Greater GI symptom severity was associated with poorer mental and physical health ( P < .01). Chemotherapy was associated with increased belly pain ( B = 4.83, SE = 1.65, P < .01) and gas/bloating ( B = 3.06, SE = 1.45, P = .04). Conclusion We provide novel evidence that many cancer survivors experience chronic, moderate to severe GI symptoms lasting for years after cancer treatment, which are associated with worse mental and physical health. Chemotherapy is associated with specific GI symptoms. Integrative therapies are needed to address GI symptoms in cancer survivors.

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Nieboer, Peter, Ciska Buijs, Sjoerd Rodenhuis, Caroline Seynaeve, Louk V. A. M. Beex, Elsken van der Wall, Dick J. Richel, et al. "Fatigue and Relating Factors in High-Risk Breast Cancer Patients Treated With Adjuvant Standard or High-Dose Chemotherapy: A Longitudinal Study." Journal of Clinical Oncology 23, no. 33 (November 20, 2005): 8296–304. http://dx.doi.org/10.1200/jco.2005.10.167.

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PurposeDetermine whether standard or high-dose chemotherapy leads to changes in fatigue, hemoglobin (Hb), mental health, muscle and joint pain, and menopausal status from pre- to post-treatment and to evaluate whether fatigue is associated with these factors in disease-free breast cancer patients.Patients and MethodsEight hundred eighty-five patients were randomly assigned between two chemotherapy regimens both followed by radiotherapy and tamoxifen. Fatigue was assessed using vitality scale (score ≤ 46 defined as fatigue), poor mental health using mental health scale (score ≤ 56 defined as poor mental health) both of Short-Form 36, muscle and joint pain with Rotterdam Symptom Checklist, and Hb levels were assessed before and 1, 2, and 3 years after chemotherapy.ResultsFatigue was reported in 20% of 430 assessable patients (202 standard-dose, 228 high-dose) with at least a 3-year follow-up, without change over time or difference between treatment arms. Mean Hb levels were lower following high-dose chemotherapy. Only 5% of patients experienced fatigue and anemia. Mental health score was the strongest fatigue predictor at all assessment moments. Menopausal status had no effect on fatigue. Linear mixed effect models showed that the higher the Hb level (P = .0006) and mental health score (P < .0001), the less fatigue was experienced. Joint (P < .0001) and muscle pain (P = .0283) were associated with more fatigue.ConclusionIn 3 years after treatment, no significant differences in fatigue were found between standard and high-dose chemotherapy. Fatigue did not change over time. The strongest fatigue predictor was poor mental health.

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Campbell, Gillian, and Eugene Wong. "Clozapine and chemotherapy: a dangerous couple or a necessary partnership?" BMJ Case Reports 13, no. 12 (December 2020): e238377. http://dx.doi.org/10.1136/bcr-2020-238377.

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A 48-year-old man with a history of schizophrenia was diagnosed with B-cell lymphoma of the small bowel. Neutropaenia occurred secondary to chemotherapy, which led to clozapine being discontinued, which resulted in the deterioration of his mental state, in turn, affecting the treatment of lymphoma. Clozapine was later reintroduced alongside granulocyte colony-stimulating factor, leading to improved mental state without any further incidences of neutropaenia.

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Shafiee, H., R. Hassanzadeh, D. Ghasemian, and S. Ebrahimi. "Comparing the Mental Health and Hope between Radiotherapy and Chemotherapy Patients." International Journal of Psychology and Psychiatry 2, no. 1 (2014): 25. http://dx.doi.org/10.5958/j.2320-6233.2.1.004.

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Rezaee, Rita, Nasrin Shokrpour, Maryam Rahimi, and Arash Mani. "The effct of peer education on the self-efficy and mental adjustment of breast cancer patients undergoing chemotherapy." Bangladesh Journal of Medical Science 19, no. 3 (March 10, 2020): 558–66. http://dx.doi.org/10.3329/bjms.v19i3.45875.

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Background: Breast cancer ranks the first common cancer in women in Iran and is the fifth mostcommon cause of death. Peer education on the self-efficacy and mental adjustment of breastcancer patients undergoing chemotherapy can contribute to their easier adaptation to the disease.This study aimed to determine the improved mental adjustment and self-efficacy for womenundergoing chemotherapy through peer education. Study Design: This study was conductedusing pre- and post-test follow up and control design approach. 70 women with breast cancerwho underwent chemotherapy in Nemazi hospital participated in this study. Method: Usingconvenient sampling, the participant were selected and randomly assigned into two groups. Theexperimental group was randomly assigned to four groups and peer education was conductedone educational session per week for 6 weeks. To assess mental adjustment and self-efficacybefore and after the study, Mini-Mental Adjustment to Cancer Scale (Mini-MAC) and Self-Efficacy Scale for Self-Management of Breast Cancer (SESSM-B) questionnaires were used.Chi-square and t-test were used to analyze the data. Results: For the experimental group, theresults showed statistically significant improvement in self-efficacy (p<0.000) while the controlgroup showed no significant difference in self-efficacy. Mental adjustment inside each groupshowed a significant increase over the time, but no statistically difference was observed betweenthe groups. Conclusion: It is suggested that peer led education is a useful teaching strategy asa supportive intervention for women undergoing chemotherapy to improve their self-efficacyregarding breast cancer. Bangladesh Journal of Medical Science Vol.19(3) 2020 p.558-566

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Papadopoulos, A., I. Vrettos, K. Kamposioras, D. Charitos, G. Giannopoulos, D. Pectasides, D. Niakas, and T. Economopoulos. "Comparing health-related quality of life (HRQL) of cancer patients undergoing chemotherapy with family members in a tertiary hospital." Journal of Clinical Oncology 27, no. 15_suppl (May 20, 2009): e20535-e20535. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.e20535.

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e20535 Background: In Greece there is limited information concerning the HRQL of cancer patients undergoing chemotherapy. The aim of this study was to estimate and compare the HRQL of cancer patients and their relatives during the period of chemotherapy and to investigate potential differences in HRQL. Methods: 122 family members (45 men and 77 women) of mean age 48.3 ±14.5 and 122 cancer patients undergoing chemotherapy (49 men and 73 women) of mean age 56.6 ±15.4 1SD completed the SF-36 health survey by personal interview. The SF-36 health survey was used to evaluate and compare HRQL which contains eight scales measuring physical functioning (PF), role physical (RP), bodily pain (BP), general health perception (GH), vitality (VT), social functioning (SF), role emotional (RE), and mental health (MH), with higher scores (0–100 range) reflecting better-perceived health. Two component summary scores capture the overall physical and mental health (Physical Component Summary or PCS and Mental Component Summary or MCS). Data analysis was performed with SPSS version 13.0 while statistical analysis was performed with Wilcoxon signed ranks test. Results: The table below summarizes the results of our study. Conclusions: Although the physical health was significantly higher in the family members as it was expected for a healthy population, the mental health and especially MCS was significantly lower from the cancer patients undergoing chemotherapy. It seems that medical condition of the patients affects severely the mental HRQL of family members. Supportive psychological programs for both the patients and the family members seem mandatory. [Table: see text] No significant financial relationships to disclose.

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Anonymous. "Cancer care extends beyond chemotherapy." Journal of Psychosocial Nursing and Mental Health Services 35, no. 9 (September 1997): 9. http://dx.doi.org/10.3928/0279-3695-19970901-12.

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Di Giacomo, Dina, Federica Guerra, Katia Cannita, Anna Di Profio, and Jessica Ranieri. "Digital Innovation in Oncological Primary Treatment for Well-Being of Patients: Psychological Caring as Prompt for Enhancing Quality of Life." Current Oncology 28, no. 4 (July 2, 2021): 2452–65. http://dx.doi.org/10.3390/curroncol28040224.

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One side-effect of oncological treatment is chemotherapy-induced alopecia (CIA), a temporary form of hair loss that could influence patients’ mental health. Digitised scalp cooling systems are assuming an important role in the clinical setting during adjuvant treatment, promising hair loss prevention and allowing an efficient procedure to reinforce patients’ mental health during chemotherapy by avoiding CIA. The present study was carried out through two research protocols: in Research Protocol 1, we conducted a randomised clinical study to evaluate the emotional impact of using scalp cooling technology in women with BC compared with a traditional chemotherapy setting; in Research Protocol 2, we conducted an observational pre-post study involving women with BC diagnosis being under adjuvant chemotherapy in two experimental conditions: no scalp cooling application and scalp cooling application. Seventy-four women undergoing chemotherapy, aged 30–55 years, were enrolled in both research protocols. We investigated oncological patients’ psychological dimensions including body image, body appreciation, expectations, and satisfaction with the scalp cooling treatment, with reference to chemotherapy treatment applying the scalp cooling solution. Our data evidenced the need to implement a supportive clinical approach via brief, tailored psychological intervention addressing patients’ progressive adaptation to chemotherapy adverse events and their concerns regarding induced alopecia and the value of the scalp cooling system. Patients receiving the innovative chemotherapy probably coped with it by neglecting its physical impact, instead focusing on avoiding alopecia by using the technological solution and neglecting the emotional impact of chemotherapy as a severe pharmacological treatment.

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Da Ponte, G., J. Rato, C. Pinto, M. Lobo, and S. Ouakinin. "Bruxism as a Consequence of Chemotherapy?" European Psychiatry 41, S1 (April 2017): S668. http://dx.doi.org/10.1016/j.eurpsy.2017.01.1140.

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IntroductionBruxism is a syndrome with uncertain etiology but with proposed factors: psychosocial, peripheral and central. Treatment is also controversial and one of the options focuses in GABA theory and regularization of ion channels. Xelox (capecitabine + oxaliplatin) and bevacizumad is indicated for metastatic colorectal cancer, being oxaliplatin the most neurotoxic agent (acute syndrome and/or a chronic sensory neuropathy). Acute neurotoxicity is very frequent and it is a sensory and/or a motor toxicity (as tongue tingling or jaw spams). The proposed pathogenesis – neuronal hyperexcitability due to alterations of voltage-gated ion channels – is supported by mechanism of action of some treatments.Objectives and AimsReview different causes of bruxism.MethodsDescription of a clinical case.ResultsThis is a story of 76-years-old man in treatment for metastatic colon cancer that developed toxicity: nauseas (treated with haloperidol), bruxism and gingival atrophy. He was referred to psycho-oncology by involuntary movements of mouth and trunk. The patient complained of sadness, anhedonia and insomnia since recurrence of cancer and related the movements with CT. At observation he was anxious, tearfulness and agitated. He was treated for a depressive episode, but the doubt remained about involuntary movements: haloperidol was a confounding factor for oxaliplatin acute neurotoxicity, also aggravated by psychic and peripheral factors.ConclusionsThe authors believe that bruxism is linked to CT in a very complex relation that includes psychic, peripheral and central factors. Psychiatrists need to keep attention to the patient as a whole, not being seduced by easy answers like psychosocial factors.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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Porcello Marrone, Luiz Carlos, Bianca Fontana Marrone, Tharick Ali Pascoal, Lucas Porcello Schilling, Ricardo Bernardi Soder, Sheila Schuch Ferreira, Giovani Gadonski, and Jaderson Costa da Costa. "Posterior Reversible Encephalopathy Syndrome Associated with FOLFOX Chemotherapy." Case Reports in Oncological Medicine 2013 (2013): 1–3. http://dx.doi.org/10.1155/2013/306983.

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Posterior reversible encephalopathy syndrome (PRES) is a clinicoradiologic entity characterized by headaches, altered mental status, seizures, visual loss, and characteristic imaging pattern in brain MRI. The cause of PRES is not yet understood. We report a case of a 27-year-old woman that developed PRES after the use of FOLFOX 5 (oxaliplatin/5-Fluoracil/Leucovorin) chemotherapy for a colorectal cancer.

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Lee, John Muzi, Regan M. Look, Crystal Turner, Stuart K. Gardiner, Terry Wagie, Jeremy Douglas, Leslie Sorenson, et al. "Low-level laser therapy for chemotherapy-induced peripheral neuropathy." Journal of Clinical Oncology 30, no. 15_suppl (May 20, 2012): 9019. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.9019.

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9019 Background: Chemotherapy induced peripheral neuropathy (CIPN) is a common and serious side effect from chemotherapy agents. Low-level laser light therapy (LLLT) devices were approved in 2002 for pain management. Studies suggest a local release of serotonin, increased mitochondrial ATP production, or anti-inflammatory effects as a mechanism of action. We then questioned whether LLLT would show efficacy in mitigating symptoms caused by CIPN. Methods: In a single center prospective randomized trial, participants were randomized to receive either treatment with LLLT twice a week for 8 weeks or placebo LLLT twice a week for 4 weeks followed by actual treatment twice a week for 4 weeks. FACT/GOG-NTX, Brief Pain Inventory (BPI -Severity and Interference), SF-36 Quality of Life (Physical and Mental Score), monofilament and function testing (buttoning, coin use and walking) were conducted prior to initiation of therapy, during, at completion, and 2 months after treatment. 20 participants, 16 women and 4 men (average age 58 and 63 respectively), were enrolled between October 2009 and June 2010. 10 patients were randomized to each group. Average time from end of chemotherapy to enrollment was 32.6 months (range 2 - 120 mo). All patients had neuropathic involvement of the feet. 14 patients had additional involvement of the hands. Results: Compared to baseline, patients receiving any amount of active treatment showed significant improvement at 8 weeks in NTX, BPI, function testing, and SF36 Mental score. Those receiving 4 weeks of placebo treatment showed improvement in only BPI, NTX and SF36 Mental score. At 2-month follow up, all 20 patients showed a significant improvement in walking and SF 36 mental score, suggesting 4 weeks of active treatment improved function. No significant difference in monofilament testing was observed throughout the study in either group. Direct comparison between 4 or 8 weeks of treatment vs. placebo showed a statistically significant difference in walking function at 2-months. All patients tolerated therapy well without side effects. Conclusions: Low-level laser light therapy improved functional test over placebo and may be a viable option for non-medical management of CIPN. Further study of LLLT in CIPN is warranted.

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Wilairatana, Polrat, Sornchai Looareesuwan, and Douglas S. Walsh. "Chemotherapy of Cerebral Malaria." CNS Drugs 7, no. 5 (May 1997): 366–80. http://dx.doi.org/10.2165/00023210-199707050-00004.

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Kitazawa, Fumiaki, Toshio Abe, Kumi Ueda, Satoshi Murakami, Kohji Takara, Teruyoshi Yokoyama, and Hikofumi Sugii. "Effects of Pharmaceutical Care on Mental Condition of Patients Receiving Cancer Chemotherapy." Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences) 36, no. 1 (2010): 37–43. http://dx.doi.org/10.5649/jjphcs.36.37.

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Moore, H. C., G. H. Yue, M. Parsons, L. Rybicki, and V. Siemionow. "Neurophysiology of chemotherapy-associated physical and mental fatigue: A study of chemobrain." Journal of Clinical Oncology 28, no. 15_suppl (May 20, 2010): e19609-e19609. http://dx.doi.org/10.1200/jco.2010.28.15_suppl.e19609.

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Gelzer, J. "Limits to Chemotherapy of Depression." Psychopathology 19, no. 2 (1986): 108–17. http://dx.doi.org/10.1159/000285141.

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Koszalinski, Rebecca S., and Christine Williams. "Embodying Identity in Chemotherapy-Induced Alopecia." Perspectives in Psychiatric Care 48, no. 2 (July 5, 2011): 116–21. http://dx.doi.org/10.1111/j.1744-6163.2011.00314.x.

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Li, Tiffany, David Mizrahi, David Goldstein, Matthew C. Kiernan, and Susanna B. Park. "Chemotherapy and peripheral neuropathy." Neurological Sciences 42, no. 10 (August 26, 2021): 4109–21. http://dx.doi.org/10.1007/s10072-021-05576-6.

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Ai, Zhongping, Xiaolan Gao, Silin Zheng, and Changbi Lu. "Variability and Influencing Factors of QOL in Breast Cancer Patients Having Chemotherapy." Clinical Nursing Research 29, no. 8 (October 3, 2018): 571–78. http://dx.doi.org/10.1177/1054773818803691.

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Variability and factors influencing quality of life (QOL) in breast cancer patients having chemotherapy were examined in a longitudinal prospective cohort study in two teaching hospitals in China. Physical, mental, social/family, and functional QOL changed significantly over time with varying patterns. In addition, various factors influenced the QOL of breast cancer patients at each chemotherapy cycle. Health professionals should focus on critical time periods during chemotherapy, particularly at baseline and during the fourth and fifth cycles when the QOL in our sample was at the lowest point, and they should provide additional support to patients to ensure that chemotherapy is delivered in an optimal fashion.

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Strain, J. J., S. Bhardwaj, S. Schleifer, A. Lebovits, and J. Tanaka. "Physician nonadherence to breast cancer chemotherapy protocols." General Hospital Psychiatry 13, no. 6 (November 1991): 363–64. http://dx.doi.org/10.1016/0163-8343(91)90060-a.

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Cohn, Kenneth H. "Chemotherapy from an Insider's Perspective." Journal of Psychosocial Oncology 7, no. 4 (March 2, 1990): 131–36. http://dx.doi.org/10.1300/j077v07n04_11.

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Alshehri, Sultan, Hatem Assiri, Moayyad Alsalem, and Majed A. Alharbi. "Secondary Psychosis Following Neoadjuvant AC-T Chemotherapy for Triple-Negative Breast Cancer: Case Report and Literature Review of Psychosis Postchemotherapy." Case Reports in Psychiatry 2022 (October 28, 2022): 1–6. http://dx.doi.org/10.1155/2022/4939219.

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Triple-negative breast cancer is a unique subtype among breast cancers. Management includes a neoadjuvant chemotherapy regimen. Psychiatric complications of the regimen have not been reported before. We present a case of acute psychosis after the second cycle of chemotherapy in a 42-year-old woman with triple-negative breast cancer. The patient presented with sudden irritability, agitation, disorganization in speech and behavior, and paranoia involving her coworkers conspiring against her and causing her trouble with the law for 4 days. She was in her usual state of health until after her second cycle of chemotherapy. This was the first presentation of psychotic symptoms in her life. She was conscious and oriented. There were no neurologic deficits. She denied any change in her mood and any features of hallucinations. She was uncooperative, restless, had flight of ideas, and persecutory delusions. The remainder of the examination was normal. An autoimmune process, nervous system infection, or psychosis secondary to the chemotherapy were suspected. Serum electrolytes and other biochemical parameters were normal. Imaging of the brain showed no signs of acute brain insults or intracranial metastasis. Cerebrospinal fluid analysis and culture showed no abnormality or growth. The work-up revealed that neurologic, infectious, or autoimmune causes of her psychotic symptoms were less likely. Thus, a diagnosis of psychosis secondary to chemotherapy was considered. Treatment was with paliperidone, risperidone, clonazepam, and sertraline. Over the course of treatment, she showed substantial improvement and completed all of the chemotherapy sessions without adverse effects. In summary, we report a case of a patient whose initial chemotherapy course was complicated by psychosis. Since the neurotoxic and psychiatric effects of chemotherapeutics are not yet sufficiently elucidated, our case emphasizes that early signs of behavioral changes in patients receiving chemotherapy should trigger comprehensive psychiatric evaluation and monitoring of the patient’s mental state.

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Ali Hassan, Hafiz Abdul Majeed, and Azizullah Kakar. "Case study: A qualitative study aimed at comparing standard therapy in a breast cancer patient to the spiritual healing and psychological support, in improving patient’s compliance." Journal of Contemporary Pharmacy 4, no. 2 (January 31, 2021): 39–43. http://dx.doi.org/10.56770/jcp2020423.

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Background: Breast tumor is the most well-known type of cancerous growth in ladies of Pakistan. The effect of theunderlying diagnosis, treatment conventions, chemotherapeutic agents in contrast with culture, social and psychological parts of the ailment is not settled. Method: This subjective review analyzed and contrasted thestandard treatment conventions and the Spiritual Healing including psychological support utilized by patient withbreast cancer in connection to its effect on the enhanced quality of her life and her enhanced wellbeing status. MrsFouzia Mohsin a patient with bosom malignancy persistent, mother of 6 youngsters having an age of 53 years and 5months from Faisalabad experiencing chemotherapy from Shifa International Hospital Islamabad and also SpiritualHealing and mental support was met. Information were dissected utilizing topical examination. The patient'sunderstanding of bosom disease concentrated on the conviction of suitability of medication treatment picked by herphysician and in addition the positive mental impact of Spiritual recuperating alongside the scope of feelings felt allthrough her ailment. Results: The significance of spiritual healing and mental support of the family along withbreast cancer tackling techniques i.e chemotherapy, radiotherapy and mastectomy is far excessively helpful andsteady in method for upgrading consistence to treatment and accordingly enhanced personal satisfaction. This is the principal study to look into the case of lady experiencing breast cancer on the experiencing chemotherapy andSpiritual Healing. This article gives illumination of the voiced encounters of a woman with breast tumor. The information not just highlights the part of standard chemotherapy and radiotherapy as fundamental adaptingmethodologies additionally underlines the adapting of issues like disengagement, hostility, and outrage as regularreactions to chemotherapy through Spiritual Healing and Psychological support of the family. Conclusion: One of akind elements are bosom malignancy patient's have to look for Spiritual Healing and Support of family for hersickness to remain spurred and increment in her consistence. These social elements require advance examination and research.

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Manne, Sharon L., Marzio Sabbioni, Dana H. Bovbjerg, Paul B. Jacobsen, Kathryn L. Taylor, and William H. Redd. "Coping with chemotherapy for breast cancer." Journal of Behavioral Medicine 17, no. 1 (February 1994): 41–55. http://dx.doi.org/10.1007/bf01856881.

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Dębska, Grażyna, Małgorzata Pasek, and Ewa Wilczek-Rużyczka. "Sense of Coherence vs. Mental Load in Nurses Working at a Chemotherapy Ward." Central European Journal of Public Health 25, no. 1 (March 1, 2017): 35–40. http://dx.doi.org/10.21101/cejph.a4305.

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de Jong, N., M. J. J. M. Candel, H. C. Schouten, H. Huijer Abu-Saad, and A. M. Courtens. "Course of mental fatigue and motivation in breast cancer patients receiving adjuvant chemotherapy." Annals of Oncology 16, no. 3 (March 2005): 372–82. http://dx.doi.org/10.1093/annonc/mdi095.

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Mulhern, R. K., M. E. Horowitz, E. H. Kovnar, J. Langston, R. A. Sanford, and L. E. Kun. "Neurodevelopmental status of infants and young children treated for brain tumors with preirradiation chemotherapy." Journal of Clinical Oncology 7, no. 11 (November 1989): 1660–66. http://dx.doi.org/10.1200/jco.1989.7.11.1660.

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In an effort to reduce the severity of late neurotoxicities associated with cranial irradiation, 14 infants and young children with malignant brain tumors were given preirradiation chemotherapy for 2 to 22 months (median, 8 months). Prospective neurodevelopmental evaluations were routinely conducted and now extend from 35 to 60 months (median, 41 months) postdiagnosis, and 10 to 52 months (median, 31 months) postirradiation in the 12 surviving children. At the initiation of chemotherapy, less than one fourth of the patients displayed normal performance status or mental functioning on age-corrected tests; the majority remained stable or declined while receiving chemotherapy. Declining mental development and adaptive behavior were noted in six patients following radiation therapy with only two patients now functioning in the normal range for age. The analysis suggests that neurodevelopmental progress is a function of multiple factors, including neurologic and sensorimotor deficits associated with the tumor, surgical intervention, and chemotherapy that antedated radiation therapy. This implies that delaying irradiation will not necessarily improve the patients' functional status. Whether the interval of postponement of irradiation evidenced in this sample will translate into an ultimately better quality of life remains unknown. Given the probable interaction of multiple risk factors, well-controlled prospective clinical trials are needed to definitively analyze this issue.

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Baati, I., L. Mnif, J. Masmoudi, C. Allouche, R. Damak, N. Halwani, A. Feki, N. Ayadi, and A. Jaoua. "P03-10 - Psychological impact of chemotherapy induced alopecia." European Psychiatry 25 (2010): 869. http://dx.doi.org/10.1016/s0924-9338(10)70860-9.

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Johnson, B. E., B. Becker, W. B. Goff, N. Petronas, M. A. Krehbiel, R. W. Makuch, G. McKenna, E. Glatstein, and D. C. Ihde. "Neurologic, neuropsychologic, and computed cranial tomography scan abnormalities in 2- to 10-year survivors of small-cell lung cancer." Journal of Clinical Oncology 3, no. 12 (December 1985): 1659–67. http://dx.doi.org/10.1200/jco.1985.3.12.1659.

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In order to evaluate the relationship between neurologic function and cranial irradiation, 20 patients treated on National Cancer Institute (NCI) small-cell lung cancer (SCLC) trials who were alive and free of cancer 2.4 to 10.6 years (median, 6.2) from the start of therapy were studied. All were tested with a neurologic history and examination, mental status examination, neuropsychologic testing, and review of serial computed cranial tomography (CCT) scans. Fifteen patients had been treated with prophylactic cranial irradiation (PCI), two patients with therapeutic cranial irradiation, and three received no cranial irradiation. All patients but one were ambulatory and none were institutionalized. Fifteen patients (75%) had neurologic complaints, 13 (65%) had abnormal neurologic examinations, 12 (60%) had abnormal mental status examinations, 13 (65%) had abnormal neuropsychologic testing, and 15 (75%) had abnormal CCT scans. Compared with those given low-dose maintenance chemotherapy during PCI using 200 to 300 rad per fraction, patients who were given high-dose induction chemotherapy during the time of cranial irradiation or large radiotherapy fractions (400 rad) were more likely to have abnormal mental status examinations (6/6 v 4/9) and abnormal neuropsychologic tests (6/6 v 4/9), but no major difference in CCT findings was present. CCT scans in the majority of cases (11/18) showed progressive ventricular dilatation or cerebral atrophy up to 8 years after stopping therapy. We conclude neurologic abnormalities are common in long-term survivors of SCLC, and may be more prominent in patients given high-dose chemotherapy during cranial irradiation or treated with large radiotherapy fractions. The CCT scan abnormalities are common and progressive years after prophylactic cranial irradiation and chemotherapy are stopped.

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Claessens, Anouk K. M., Reinier Timman, Jan J. Busschbach, Jeanette M. Bouma, Jeany M. Rademaker-Lakhai, Frans L. G. Erdkamp, Vivianne C. G. Tjan-Heijnen, and Monique E. M. M. Bos. "The influence on quality of life of intermittent scheduling in first- and second-line chemotherapy of patients with HER2-negative advanced breast cancer." Breast Cancer Research and Treatment 179, no. 3 (November 28, 2019): 677–85. http://dx.doi.org/10.1007/s10549-019-05495-3.

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Abstract Background The Stop&Go study randomized patients with advanced breast cancer to intermittent (two times four) or continuous (eight subsequent cycles) first- and second-line chemotherapy. Methods QoL was measured with RAND-36 questionnaires every 12 weeks. The primary objective was to estimate differences in changes from baseline between intermittent and continuous treatment. An effect size of 0.5 SD (5 points) was considered clinically meaningful. Results A total of 398 patients were included with a median follow-up of 11.4 months (IQR 5.6–22.2). Mean physical QoL baseline scores were 38.0 resp. 38.2, and mental scores 45.0 resp. 42.4 for intermittent and continuous treatment. Physical QoL declined linearly in the intermittent arm causing a clinically meaningful difference of 5.40 points at 24 months (p < 0.001), while scores in the continuous arm stabilized after a small decline of ± 3.4 points at 12 months. Conversely, mental QoL was fairly stable and even improved with 1.58 (p = 0.005) and 2.48 points (p < 0.001) at 12 months for intermittent and continuous treatment, respectively. When comparing arms for both components in changes from baseline, the maximum differences were 2.46 (p = 0.101) and 1.95 points (p = 0.182) for physical and mental scores, both measured at 30 months and in favor of continuous treatment. Conclusion Intermittent first- and second-line chemotherapy in patients with HER2-negative advanced breast cancer showed a trend for worse impact on QoL compared to continuous chemotherapy, with neither significant nor meaningful differences in course. We recommend prescribing chemotherapy continuously until progressive disease or unacceptable toxicity. Trial registration EudraCT 2010-021519-18; BOOG 2010-02

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Lauriola, Marco, and Manuela Tomai. "Biopsychosocial Correlates of Adjustment to Cancer during Chemotherapy: The Key Role of Health-Related Quality of Life." Scientific World Journal 2019 (March 10, 2019): 1–12. http://dx.doi.org/10.1155/2019/9750940.

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Background. Patients adjust to cancer in a continuous process that follows the course of the disease. Previous research has considered several illness-related variables and demographics, quality of life, personality, and social factors as predictors of adjustment to cancer, which can be maladaptive (e.g., helplessness-hopelessness and anxious preoccupation) or adaptive (e.g., fighting spirit). Aims. Assuming a biopsychosocial view, we test an empirical model in which disease stage, patient’s age, and gender are viewed as the distal antecedents of positive and negative adjustment to cancer for chemotherapy patients. Health-related quality of life (HRQoL) has a key role, interposing between the distal antecedents and adaptational outcomes. Social support and positive thinking are also included in the model as related to adjustment. Methods. One-hundred-sixty-two consecutive cancer patients receiving adjuvant or standard chemotherapy participated in the study. Patients completed the Mini-Mental Adjustment to Cancer, the Brief-COPE, the Social Provision Scale, and the SF-12 Health Survey. Partial least squares structural equation modeling (PLS-SEM) was applied for model building and hypotheses testing. Results. We found a negative association between advanced stage and physical functioning, a strong positive link between physical functioning and mental health, and significant relations between mental health and helpless-hopelessness, anxious preoccupation, and cognitive avoidance. Social support and positive thinking were related to fighting spirit and fatalism. Cancer stage and female gender were indirectly associated with adaptational outcomes through HRQoL. The patient’s age had no significant relationships in the model. Discussion. HRQoL (both physical and mental) is a key factor for preventing maladjustment in chemotherapy patients. Social support and positive thinking coping style fosters fighting spirit and fatalism on health outcomes. Two potential lines of action seem promising: preventing maladaptive and promoting adaptive adjustments working on patient’s mental health individually and involving significant others in supportive care, respectively.

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Silva, M., M. Roque, P. Macedo, and A. Fornelos. "Chemobrain and Anxiety in a Patient with Hodgkin's Lymphoma: Case Report and Literature Discussion." European Psychiatry 41, S1 (April 2017): S671. http://dx.doi.org/10.1016/j.eurpsy.2017.01.1149.

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Impaired cognitive function is a common complaint among oncologic patients. Chemotherapy-induced cognitive impairment (CICI), also called “chemobrain” or “chemofog” is currently recognized as a relatively common adverse effect of chemotherapeutic agents and is defined as the impairment of patients’ memory, learning, concentration, reasoning, executive function, attention, and visuospatial skills during and after discontinuation of chemotherapy. In particular, it is apparent that a subset of chemotherapy-treated haematological malignancy survivors experience cognitive impairment. On the other hand, the emotional distress associated with the disclosure of cancer diagnosis and/or the administration of chemotherapy represents a strong reason for psychosomatic manifestations in patients with cancer. The authors report a case of a patient with Hodgkin's lymphoma, cognitive impairment and symptoms of anxiety and they propose to discuss the controversies around the factors implicated on cognitive impairment in oncological patients.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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Sadovnichaja, V., E. Ledin, M. Kovyazina, and S. Kirsanova. "Concern about chemotherapy in oncological patients first referred to this treatment predicts negative emotions." European Psychiatry 64, S1 (April 2021): S434. http://dx.doi.org/10.1192/j.eurpsy.2021.1158.

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IntroductionTreatment representation is an important factor of motivation and well-being during treatment (Horne, 2002).ObjectivesThe aim was to reveal the relationship between treatment representation and well-being in oncological patients first referred to chemotherapy.Methods40 oncological patients (10 males, 20-72 years old, mean age 50.49±13.75 years old, localizations included gastrointestinal tract and genitourinary system) first referred to chemotherapy filled Satisfaction with Life Scale (Diener et al., 1985), Scale for Positive and Negative Experiences (Diener et al., 2009), Hospital Anxiety and Depression Scale (Zigmond, Snaith, 1983) and Beliefs about Medication Questionnaire (Horne, 2002) that was slightly modified for the situation of chemotherapy. Disturbance of functioning was assessed in the interview as an opportunity to cope with job, home responsibilities or self-care (1-5-point Likert scale).ResultsCronbach’s alphas for Necessity and Concern scales were .69 and .76. Despite high appraisals of necessity of chemotherapy (mean 4.24±.53 on 1-5 Likert scale), concern about it was rather high (2.83±.82). Hierarchical regression analyses revealed that, after adjusting for disturbances in social functioning, concern about chemotherapy (but not its subjective necessity) predicted more severe negative emotions (β=.32, p<.05, ΔR2=10.0%). After control for general level of anxiety and depression, this relationship became weaker but marginally significant (β=.32, p<.10, ΔR2=8.4%).ConclusionsConcern about chemotherapy in patients first referred to this treatment could be important predictor of well-being demanding for interventions aimed at stabilization of emotional reaction to chemotherapy regardless belief in its necessity.

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Thakur, Reena. "Effect of structured interventional programme on knowledge regarding post effect of parenteral chemotherapy and its management among patients admitted in oncology units." International Journal of Clinical Biochemistry and Research 9, no. 3 (September 15, 2022): 210–17. http://dx.doi.org/10.18231/j.ijcbr.2022.042.

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Patients who are treated for cancer may experience difficult emotional responses, in addition to physical discomfort. Chemotherapy is associated with a number of side effects, such as nausea and vomiting, loss of appetite, mucositis, diarrhoea, infections, fatigue and emotional distress. Receiving chemotherapy treatment was perceived as difficult, and the experienced side effects negatively influenced patient’s bodies and moods. The research process for this study was guided by conceptual framework based on Kings Goal Attainment theory. A pre-experimental, One-group pre-test post-test design was undertaken for the study. The independent variable for the study was the structured interventional programme on post effect of chemotherapy and its management and the dependent variable was knowledge of patients admitted in oncology unit. The study was conducted in oncology unit of S.G.P.T. government cancer hospital, Indore. The samples for the study were the patients admitted in oncology unit and the sample size for the study were 300. Non- probability convenient sampling technique was utilized to select the sample from the population. Patients were assessed using the structured knowledge questionnaire for knowledge regarding post effect of parenteral chemotherapy and its management. After assessing knowledge Structured Interventional Programme was implemented. After intervention on 7 day the post-test knowledge was assessed. The analysis revealed that in the pre-test, 195 (65.0%) patients had obtained inadequate knowledge score, 91 (30.3%) patients had obtained moderate knowledge score and 14 (4.7%) patients had obtained adequate knowledge score. In the post-test, majority 192 (64.0%) patients had obtained adequate knowledge score, 58 (19.3%) patients had obtained moderate knowledge score and 50 (16.7%) patients had obtained inadequate knowledge score. Findings revealed that the mean pre-test knowledge score was 14.74 ± 6.03, while the post-test knowledge score was 24.69 ± 7.12.The student paired ‘t’ test value of the group was t = 33.063. The difference was found to be statistically significant (p<0.05), showing a significantly higher post-test knowledge in comparison to the pre-test knowledge score. It infers that the structured interventional programme on knowledge regarding post effect of parenteral chemotherapy and its management among patients were effective in improving the knowledge level of patients. Findings in present study also reveal that pre-test knowledge score statistically associated with the age, sex, marital status, educational status, occupation area, history of cancer in family of the patients, habit of the patients, number of chemotherapy cycle receiving, body system affected with cancer and the previous information about parenteral chemotherapy and its management.The study concluded that Structured Interventional Programme was effective in improving the knowledge of patients on post effect of parenteral chemotherapy and its management. The study recommended the utilization of structured interventional programme by community health nurses, nurse researchers, nurse administrators, nurse educators and health care professionals to improve knowledge of cancer patients receiving chemotherapy.

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Thorsen, Lene, Eva Skovlund, Sigmund B. Strømme, Kjersti Hornslien, Alv A. Dahl, and Sophie D. Fosså. "Effectiveness of Physical Activity on Cardiorespiratory Fitness and Health-Related Quality of Life in Young and Middle-Aged Cancer Patients Shortly After Chemotherapy." Journal of Clinical Oncology 23, no. 10 (April 1, 2005): 2378–88. http://dx.doi.org/10.1200/jco.2005.04.106.

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Purpose To evaluate the effectiveness of a supervised home-based flexible training program on cardiorespiratory fitness (CRF), mental distress, and health-related quality of life (HRQOL) parameters in young and middle-aged cancer patients shortly after curative chemotherapy. Patients and Methods One hundred eleven patients age 18 to 50 years who had received chemotherapy for lymphomas or breast, gynecologic, or testicular cancer completed the trial. These patients were randomly allocated to either an intervention group (n = 59), which underwent a 14-week training program, or a control group (n = 52) that received standard care. Primary outcome was change in CRF, as determined by Åstrand-Rhyming indirect bicycle ergometer test (maximum oxygen uptake [VO2max]), between baseline (T0) and follow-up (T1). Secondary outcomes were mental distress, as assessed by the Hospital Anxiety and Depression Scale, and HRQOL, as assessed by the European Organisation for Research and Treatment of Cancer Core Quality of Life Questionnaire. Two-way analysis of covariance was used to analyze changes from T0 to T1. Results VO2max increased by 6.4 mL/kg–1/min–1 in patients in the intervention group and by 3.1 mL/kg–1/min–1 in patients in the control group (P < .01). The fatigue score decreased by 17.0 points in the control group compared with only 5.8 points in the intervention group (P < .01). There were no intergroup differences in mental distress or HRQOL. Conclusion A supervised, home-based, flexible training program has significant effect on CRF in young and middle-aged cancer patients shortly after curative chemotherapy, but it has no favorable effect on patients' experience of fatigue, mental distress, or HRQOL.

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Suetina, O. A. "Organic mental disorders in children and adolescents with a history of blood cancer." Russian Journal of Child Neurology 14, no. 3 (January 16, 2020): 11–15. http://dx.doi.org/10.17650/2073-8803-2019-14-3-11-15.

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We performed clinical examination of 60 children and adolescents in remission followed up in Research Institute of Pediatric Oncology and Hematology, N.N. Blokhin National Medical Research Center of Oncology. All patients were found to have complex organic disorders of varying severity, primarily induced by aggressive methods of treatment (such as polychemotherapy, high-dose chemotherapy, and cranial irradiation).

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Varkaneh, Seyed Shahabeddin Bahrani, Zahra Kurd. "A Systematic Review of the Role of Medicinal Plants in the Treatment of Chemotherapy Induced Nausea and Vomiting." International Journal of Psychosocial Rehabilitation 24, no. 4 (April 30, 2020): 7888–96. http://dx.doi.org/10.37200/ijpr/v24i4/pr2020738.

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Hadi, Dalal Abbas. "Spectrum of Bacterial Infection and Antibiotic Susceptibility Profile among Clinical Samples of Febrile Pediatric Cancer Patients under Chemotherapy." International Journal of Psychosocial Rehabilitation 24, no. 5 (March 31, 2020): 1189–203. http://dx.doi.org/10.37200/ijpr/v24i5/pr201794.

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Coffey, Barbara J. "Chemotherapy in Psychiatry: Principles and Practice." Journal of the American Academy of Child & Adolescent Psychiatry 26, no. 5 (September 1987): 817–18. http://dx.doi.org/10.1097/00004583-198709000-00043.

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Blayney, Douglas W., Amee Azad, Melih Yilmaz, Selen Bozkurt, James D. Brooks, and Tina Hernandez-Boussard. "Four distinct patient-reported outcome (PRO) trajectories in longitudinal responses collected before, during, and after chemotherapy." Journal of Clinical Oncology 38, no. 15_suppl (May 20, 2020): 2012. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.2012.

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2012 Background: Cancer chemotherapy, whether given with curative or palliative intent, is toxic. Toxicity is routinely captured in clinical trials by investigator observation and increasingly by PRO. The ability to capture PRO in the routine treatment workflow has been standard at Stanford since 2015 (Roy et al ASCO 2020). Analysis of longitudinally captured, real world PRO and prospectively identifying patients (pts) whose quality of life (QOL) is at risk of deteriorating either permanently or temporarily is needed. Routine serial PRO measurement should enhance precision care delivery, precision toxicity detection and management. Methods: We identified patients undergoing chemotherapy at Stanford and analyzed PROMIS (PRO Measurement Information System) responses. Pts with PROMIS survey information at three intervals—pre-treatment, during chemotherapy and post chemotherapy—were identified. We evaluated global physical health (GPH) and global mental health (GMH). Pts with a clinically significant decrease (CSD) in GPH or GMH scores were identified. A k-median cluster analysis was used to identify patient trajectory clusters and a machine-learning model was applied to identify risk factors for CSD and predict CSD. Results: We identified 670 adult oncology patients undergoing chemotherapy who completed at least one PROMIS survey in each interval. GPH scores were 48.4 ± 9.1 before, 47.1 ± 8.5 during, and 48.5 ± 8.9 after chemotherapy and GMH scores were 50.5 ± 8.2, 49.1 ± 8.5, and 50.7 ± 9.0, respectively. The majority of patients did not have a CSD in GPH or GMH post treatment compared to pretreatment scores. Pretreatment scores were the strongest predictor of a CSD in GPH and GMH. Trajectory clustering identified four distinct trajectories: Temporary Improver, Temporary Deteriorator, Improver, Inexorable Deteriorators. We were not able to predict any cluster based on pre-treatment features. Conclusions: Using routinely collected PROMIS surveys in a real-world setting, we are able to predict patients with post-treatment decreases in their physical and mental well-being. We further defined four novel patient trajectories during chemotherapy, which could guide personalized supportive interventions to improve patient’s chemotherapy experience. Identification of patients at risk for deterioration and the patterns of deterioration could help guide efficient deployment of toxicity mitigating and supportive care interventions to patients most in need.

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Wan, Y. M., and C. B. Khare. "P-415 - Chemotherapy-induced pseudobulbar affect: A novel case." European Psychiatry 27 (January 2012): 1. http://dx.doi.org/10.1016/s0924-9338(12)74582-0.

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Schwarz, Reinhold, and Ute Michel. "Chemotherapy and psychological side-effects in breast cancer patients." Stress Medicine 1, no. 3 (July 1985): 221–24. http://dx.doi.org/10.1002/smi.2460010313.

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Li, Panpan, Jiangli Yu, Xiaohui Wang, Xiaonan Pang, Chengjing Yu, and Yingqiong Xu. "Study on the Evaluation of Lung Cancer Patients from the Three Aspects of Emotion." Contrast Media & Molecular Imaging 2022 (September 15, 2022): 1–10. http://dx.doi.org/10.1155/2022/8139680.

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In recent years, epidemiological survey data have shown that lung cancer is the tumor with the fastest increase in cancer incidence and mortality in China. The incidence and mortality of lung cancer in China rank first among tumors, and 80% of patients die within one year of diagnosis. This paper aims to study the evaluation of lung cancer patients from three aspects of emotion, coping style, and Quality of Life (QoL), expounding on the changes in emotion, coping style, and QoL in lung cancer patients after chemotherapy. We assess the negative emotions and survival of lung cancer patients after chemotherapy quality satisfaction survey research. We investigate the general data, QoL, and coping styles of 219 lung cancer patients undergoing chemotherapy before, during, and after chemotherapy based on the artificial intelligence processor. All survey data are input into SPSS 19 for descriptive and relevant statistical analysis. The experimental results show that under a survey of 219 lung cancer chemotherapy patients with negative emotions and QoL satisfaction after chemotherapy, at a significance level of = 0.05, there is a linear regression relationship between mental resilience and anxiety and depression.

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Rasskazova, E., M. Kovyazina, and M. Karakurchi. "Subjective expectations from radiotherapy and chemotherapy in patients with oncological illnesses." European Psychiatry 65, S1 (June 2022): S658—S659. http://dx.doi.org/10.1192/j.eurpsy.2022.1691.

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Introduction Expectations and fears about chemotherapy and radiotherapy in patients with oncological illness may not only affect their subjective well-being (Shaverdian et al., 2018) but also treatment satisfaction and complaints of side effects (Guidolin et al., 2018, Dong et al., 2014, Colagiuri et al., 2013). Objectives The aim was to compare beliefs about treatment in patients referred to radiation therapy and chemotherapy, and to reveal their relationship to health anxiety and subjective well-being. Methods 53 patients referred to radiation therapy and 63 patients referred to chemotherapy completed the Treatment Perception in Oncological Illnesses Scale (Kovyazina et al., 2021), Illness and Treatment Self-Regulation Questionnaire (Kovyazina et al., 2019), Satisfaction with Life Scale (Diener et al., 1985) and Scale of Positive and Negative Experiences (Diener et al., 2009). Results Compared to radiation therapy, with chemotherapy, patients tend to be more doubtful about the effectiveness of treatment and more anxious about the need for it (p<.05). Moderated mediation analysis demonstrated that lack of understanding, doubts about the effectiveness and anxiety about radiation and chemotherapy are associated with subjective ill-being indirectly - through a higher level of health anxiety (β=-.79--.35, SE=.17-.26, 95% CI [-1.42 - -.75 – -.37 - -0,08]). Feelings of helplessness regarding treatment mediated the relationship between doubts and confidence about treatment effectiveness and well-being in both groups. Conclusions Results demonstrated that some fears and expectations about chemo- and radiotherapy could provoke health anxiety and helplessness regarding treatment that is related to poorer well-being. Disclosure No significant relationships.

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Rasskazova, E., and S. Kirsanova. "Illness and tretment representation in onological patients undergoing chemotherapy: relationship with subjective well-being." European Psychiatry 65, S1 (June 2022): S140. http://dx.doi.org/10.1192/j.eurpsy.2022.379.

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Introduction The knowledge, expectations, fears that a patient has about the oncological disease and treatment can affect the quality of life of patients (Colagiuri et al., 2013; Whitford, 2012). Objectives The aim was to reveal the relationship between well-being of patients with cancer undergoing chemotherapy and their illness and treatment representation. Methods 110 patients undergoing chemotherapy in Medsi Clinical Hospital filled Chemotherapy Attitudes Questionnaire (Zinchenko et al., 2020), Life Satisfaction Scale (Diener et al., 1985), Scale of Positive and Negative Experience (Diener et al., 2009), Quality of Life Questionary C30 (Aaronson N. K. et al., 1994), Illness Perception Questionnaire (Moss-Morris et al., 2002), Self-Regulation Questionnaire in the Rehabilitation Process (Kovyazina M. et al, 2019), Hospital Anxiety and Depression Scale (Zigmond, Snaith, 1983). Results Correlation analysis revealed that patients with severe difficulties in physical functioning had a lower level of life satisfaction (R = -0.23, p <.05) and quality of life (R = -0.35, p <.001), perceived disease as long-term (R = 0.34; p <0.001), cyclical (R = 0.33; p <0.001) and carrying significant negative consequences for life (R = 0.55; p <0.001), also these patients were characterized by anxiety about health during treatment (R = 0.37; p <0.001). Perception of illness duration, personal control, emotional representations, self-efficacy, confidence in the effectiveness of treatment can predict the level of satisfaction with life of cancer patients undergoing chemotherapy (R2 increased from 0.05 to 0.37, p<0.001). Conclusions Health anxiety, illness duration, personal control, self-efficacy could be targets for interventions in patients undergoing chemotherapy. Disclosure No significant relationships.

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Journal articles on the topic 'Mental Chemotherapy'

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