Dissertations / Theses on the topic 'Menopause'
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Antoine, Caroline. "Menopause, breast cancer and menopausal treatments." Doctoral thesis, Universite Libre de Bruxelles, 2018. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/271843.
Full textABSTRACT Introduction: Breast cancer (BC) is the most common cancer in women. BC risk is influenced by many factors. Menopausal hormone therapy (MHT) is one of them. BC risk associated with MHT may vary depending on the treated population, the type of MHT used, the treatment duration and the delay between the beginning of the treatment and the onset of the menopause. There are alternatives to MHT for the treatment of menopausal symptoms. Some of them have shown some efficacy but have side-effects. Others need further research. Objectives: (1) To contribute to the analysis of the influence of MHT on BC; (2) to contribute to the improvement of the quality of life of BC patients. Results: (1) We analysed changes in BC incidence and MHT sales in Belgium and showed a correlation between these two parameters. We made a systematic review of studies analysing the association between BC incidence and MHT use. All the studies had limitations and were heterogeneous, making them difficult to compare. We analysed changes in MHT sales in Europe and showed an important decrease during the last decade in all the studied countries. We analysed changes in BC incidence and MHT sales in several European countries and found no association between these two parameters. We made a systematic review of studies assessing the influence of MHT on BC characteristics and showed that cases of BC developed under MHT did not have a better prognosis. (2) We made two systematic reviews on the safety of MHT and non-hormonal treatments in BC patients. We showed that BC was a contra-indication to MHT and that few data on alternative treatments were available. We conducted two studies on the use of treatments to alleviate menopausal symptoms in BC patients and showed that an important proportion of these women suffered menopausal symptoms but that few of them were using a treatment. Some of these treatments could reduce the efficacy of their BC treatment. Conclusions: (1) The exact influence of MHT on BC incidence is difficult to evaluate. Other factors are also involved. We showed that long follow-ups are needed when analysing time trends. (2) Efficient and safe treatments for menopausal symptoms in BC patients are limited. However, the quality of life of BC patients may be improved.
Doctorat en Sciences biomédicales et pharmaceutiques (Médecine)
info:eu-repo/semantics/nonPublished
Pimenta, Filipa. "Menopause and midlife: menopausal symptoms, body weight and well-being." Doctoral thesis, ISPA - Instituto Universitário, 2011. http://hdl.handle.net/10400.12/1346.
Full textA menopausa tem sido genericamente definida como um fenómeno bio-médico, tendo como consequência a emergência de sintomas físicos e psicológicos decorrentes da diminuição de estrogénios endógenos. O presente trabalho pretende alargar esta conceptualização da menopausa, contextualizando-a no modelo bio-psico-sócio-cultural, explorando se variáveis pessoais (como a espiritualidade) e contextuais (por exemplo, acontecimentos de vida) podem predizer sintomas reconhecidos como de menopausa. É ainda objectivo deste estudo explorar que variáveis estão associadas ao aumento de peso na transição para a menopausa e na pós-menopausa, e se uma intervenção breve cognitivo-comportamental pode promover a diminuição de peso em mulheres com obesidade e excesso de peso. Finalmente, pretende-se construir um modelo causal de bem-estar subjectivo na meia-idade. Uma amostra comunitária constituída por 1.003 mulheres com idades compreendidas entre os 42 e os 60 anos, recolhida maioritariamente através de estabelecimentos de ensino na área de Lisboa, preencheu um questionário para recolha de informação sócio-demográfica, relacionada com saúde, menopausa e estilo de vida. As participantes responderam ainda a instrumentos validados para averiguar o bem-estar subjectivo, depressão, ansiedade e stress, sintomas de menopausa, percepção de controlo sobre os afrontamentos, espiritualidade, acontecimento de vida e preocupações com a forma corporal. Desta amostra, 17 mulheres com excesso de peso ou obesidade participaram numa intervenção cognitivo-comportamental individual para a perda de peso. Antes da intervenção, imediatamente após e quatro meses depois do seu término, as participantes foram avaliadas em relação a medidas antropométricas, psicológicas e de comportamento alimentar. Os resultados mostram que, tanto os acontecimentos de vida, como a espiritualidade, predizem de forma significativa a gravidade dos sintomas de menopausa. Além destes, também variáveis de estilo de vida, sócio-demográficas e relacionadas com o estado de saúde associam-se de forma significativa a estes sintomas. Dos doze grupos de sintomas de menopausa averiguados (psicológicos e físicos), apenas três são preditos pelo estado de menopausa. Assim, sintomas vasomotores, sexuais e alterações na pele e nos pêlos faciais são os únicos sintomas que parecem decorrer das alterações hormonais. Observou-se ainda que mulheres com uma escolaridade mais baixa, com uma prática de exercício físico mais reduzida, com um problema psicológico auto-relatado, mais preocupadas com a forma corporal e em pós-menopausa apresentavam um ganho de peso maior. A perda de peso após a intervenção mostrou-se estatisticamente significativa, comparando o peso antes da intervenção e quatro meses após a mesma, ficando contudo abaixo dos 5% do peso corporal. Verificou-se ainda que o bem-estar subjectivo na meia-idade é predito pelo humor deprimido, presença de um problema psicológico, espiritualidade, stress, acontecimentos de vida e ainda consumo de café. Esta investigação permite concluir que a maior parte dos sintomas identificados como decorrentes da menopausa são, nesta amostra, determinados por factores não hormonais, sendo a única sintomatologia consequente do estado de menopausa os sintomas sexuais, vasomotores e alterações na pele/pêlos faciais. Tal contribui para uma compreensão da menopausa para além da abordagem medicalizada que tem vigorado na literatura. Adicionalmente, são identificados factores de vulnerabilidade em relação ao aumento de peso e bem-estar na meia-idade, que permitem potenciar mudanças neste âmbito. ---------- ABSTRACT ---------- Menopause has been generically defined as a bio-medical phenomenon, having as consequence the emergence of physical and psychological symptoms, subsequent to the decrease of endogenous estrogens. The present research intends to broaden this conceptualization of menopause, contextualizing it in the bio-psycho-socio-cultural model. Therefore, we will explore if personal (such as spirituality) and contextual variables (for example, life events) can predict symptoms recognized as menopausal ones. It is also the aim of this study to investigate which variables are associated with weight gain in the menopausal transition and post-menopause. Also, it is our objective to explore if a brief cognitive-behavioural intervention can promote a weight decrease in obese and overweight women. Finally, we intend to build a causal model of subjective well-being in midlife. A community sample of 1,003 women, aged between 42 and 60 years, mainly collected in schools and universities in Lisbon, answered a questionnaire to gather socio-demographic, health and menopause-related, and lifestyle information. Moreover, participants filled in validated instruments to assess subjective well-being, depression, anxiety and stress, menopausal symptoms, perceived control over hot flashes, spirituality, life events and body shape concerns. From this sample, 17 overweight and obese women participated in an individual cognitive-behavioural intervention for weight loss. Before the intervention, immediately after and at a 4-month follow-up, participants were assessed regarding anthropometric, psychological and eating behaviour variables. Results show that both life events and spirituality significantly predicted menopausal symptoms’ severity. Besides these two, also lifestyle, socio-demographic and health-related variables were significantly associated with menopausal symptoms. From the twelve sets of menopausal symptoms assessed (psychological and physical), only three were predicted by the menopausal status. Therefore, vasomotor and sexual symptoms, and skin and facial hair changes are the only ones which appear to be a consequence of hormonal changes. Women with less schooling years, less physical activity, the presence of a self-reported psychological problem, more concerned with body shape and in post-menopause, manifested higher weight gain. The weight loss consequent to the cognitive-behavioural intervention was statistically significant, when comparing body weight prior to the intervention and weight at the follow-up; however, the loss was lower than 5% of body weight. Subjective well-being in midlife was predicted by depressive mood, presence of a psychological problem, spirituality, stress, life events and coffee intake. This research allows the conclusion that the majority of symptoms identified as menopausal are, in this sample, determined by non-hormonal factors; the only symptoms consequent to menopausal status are sexual, vasomotor and skin/facial hair changes. This outcome contributes to an understating of menopause beyond the medicalized approach that is common in the literature. Additionally, vulnerability factors for weight modifications and well-being in midlife, which allow the development of changes in this field, were identified.
Programa Operacional Ciência e Inovação (POCI 2010) da Fundação para a Ciência e Tecnologia
Al-Sejari, Maha M. "Age at natural menopause and menopausal symptoms among Saudi Arabian women in Al-Khobar." Connect to this title online, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1116611916.
Full textTitle from first page of PDF file. Document formatted into pages; contains xx, 207 p.; also includes graphics Includes bibliographical references (p. 181-207). Available online via OhioLINK's ETD Center
Stephan, Cristina [UNESP]. "Associação entre a densidade mineral óssea da coluna lombar e do fêmur e do perfil lipídico e lipoprotéico em pacientes pós-menopáusicas com osteoporose." Universidade Estadual Paulista (UNESP), 2006. http://hdl.handle.net/11449/95372.
Full textFundação para o Desenvolvimento Médico e Hospitalar (Famesp)
O objetivo deste estudo foi avaliar a associação entre a densidade mineral óssea da coluna lombar e do fêmur e o perfil lipídico e lipoprotéico em pacientes pósmenopáusicas com osteoporose. Foram avaliadas 351 pacientes com média etária de 64,4 anos, em estudo de corte transversal. Foram analisadas as correlações entre a densidade mineral óssea da coluna lombar e as distintas variáveis do perfil lipídico e lipoprotéico. Iguais correlações também foram estudadas em relação à densidade mineral óssea do colo do fêmur. Levou-se em conta para as referidas análises o tempo de pós-menopausa e o índice de massa corporal das pacientes. Ao final, pode-se concluir pela existência de associação significativa entre os níveis plasmáticos de HDLC e a presença de osteoporose do colo do fêmur somente nas pacientes com mais de 10 anos de pós-menopausa. Estas apresentaram níveis plasmáticos de HDL-C significativamente mais elevados. Não houve associação entre a densidade mineral óssea do colo do fêmur e as demais variáveis do perfil lipídico e lipoprotéico (CT, LDL-C e TG). Também não houve associação entre a densidade mineral óssea da coluna vertebral e as variáveis analisadas do perfil lipídico e lipoprotéico (CT, LDL-C, HDL-C e TG)
The aim of this study was to analyze the association between the bone mineral density (BMD) in the lumbar spine and hip and the lipid and lipoprotein profile in post-menopause women with osteoporosis. A sectional study was performed with 351 women. Their mean age was 64,4 years. We performed a linear correlation between the lumbar spine BMD and the variables of the lipid and lipoprotein profile (CT: total cholesterol; HDL-C: high lipoprotein density; LDL-C: low lipoprotein density; TG: tryglicerides). The same procedure was done with the hip BMD. We also analized the time since menopause and bone mass index. In the end of the study we concludes that there was a significant association between HDL-C plasmatic levels in the hip only in women with more than 10 years since menopause. They had HDL-C plasmatic levels signifcantly higher. There wasnþt an association between the hip BMD and the other lipid and lipoprotein variables (CT, LDL-C,TG). Also, there wasnþt an association between the lumbar spine BMD and the lipid and lipoprotein variables (CT, HDL-C, LDl-C, TG)
Fernandes, Ana Lucia Ribeiro Valadares. "Sexualidade em mulheres entre 40 e 65 anos e com onze anos ou mais de escolaridade : estudo de base populacional." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/313666.
Full textTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas
Made available in DSpace on 2018-08-10T01:32:05Z (GMT). No. of bitstreams: 1 Fernandes_AnaLuciaRibeiroValadares_D.pdf: 906029 bytes, checksum: 11e5aaa84cce63b6482eb194df48b4a1 (MD5) Previous issue date: 2007
Resumo: Objetivos: Avaliar aspectos da sexualidade e seus fatores associados em mulheres de meia-idade, com 11 anos ou mais de escolaridade. Métodos: Estudo populacional de corte transversal, com questionário anônimo auto-respondido por 378 mulheres brasileiras residentes em Belo Horizonte, Minas Gerais, entre 40 e 65 anos, com 11 anos ou mais de escolaridade, no período de maio a setembro de 2005. o instrumento de avaliação baseou-se no Short Personal Experiences Questionnaire (SPEQ). O escore de sexualidade foi calculado através da análise multivariada de sete componentes: presença de fantasias sexuais, grau de desejo, freqüência de atividade sexual, satisfação nas atividades sexuais, freqüência de excitação, orgasmo e a autoclassificação da vida sexual. Considerou-se escore de sexualidade abaixo da mediana como sexualidade ruim e maior ou igual à mediana como sexualidade boa. Para se investigar os fatores associados, os dados foram analisados usando-se a análise bivariada, com aplicação dos testes qui-quadrado e exato de Fisher. Por último, a análise por regressão múltipla de Poisson foi realizada. A razão de prevalência (RP) e o respectivo intervalo de confiança de 95% (IC 95%) foram calculados. Resultados: 276 questionários foram avaliados e, destes, 219 mulheres relataram ter parceiro sexual. A mediana do escore de sexualidade foi 9,0 (variação: 2,45-13,77). A análise de regressão múltipla mostrou que a prevalência de escore de sexualidade abaixo da mediana foi maior nas mulheres com mais idade e naquelas com insônia. Ter parceiro sexual e sentir-se bem indicaram efeito protetor contra baixo escore de sexualidade. Em mulheres com parceiro sexual, a prevalência de escore abaixo da mediana foi maior nas que moravam com o parceiro, que estavam na transição menopausal ou na pós menopausa e nas hipertensas. Ter relações sexuais com penetração e satisfação com o parceiro como amante indicaram efeito protetor contra escore de sexualidade abaixo da mediana. Conclusões: Mulheres com mais idade e que relataram insônia tiveram maior chance de ter sexualidade ruim, enquanto as com parceiro sexual e que se sentiram bem tiveram maior probabilidade de apresentar sexualidade boa. No grupo de mulheres que tinham parceiro sexual, a sexualidade foi negativamente associada ao fato de residir com o parceiro, estar na transição menopausal ou pós-menopausa e ser hipertensa. A satisfação com o parceiro como amante e ter relações sexuais com penetração diminuíram a probabilidade de apresentar sexualidade baixa
Abstract: Objectives: To evaluate aspects of sexuality and associated factors in middle aged women with 11 or more years of formal education. Methods: with living in Belo Horizonte (Minas Gerais), between 4, in the period between May and September 2005. The evaluation instrument was based on the Short Personal Experíences Questíonnaíre (SPEQ). Sexuality score was calculated from the multivariate analysis of the seven components: presence of sexual fantasies, intensity of desire, frequency of sexual activities, satisfaction in sexual activities, frequency of arousal, orgasm and self-classification of sexual life. The sexuality score below the median was considered bad sexuality and equal or higher than median as good sexuality. To investigate associated factors, data were analyzed using bivariate analysis and chi-squared and Fisher's exact tests were applied. Finally, Poisson multiple regression analysis was performed. The software used was Stata 7.0. Prevalence ratios (PR) and their 95% confidence intervals (95% CI) were calculated. Results: 276 questionnaires were evaluated and from these 219 women reported having sexual partners. The median sexuality score was 9.0 (range: 2.45-13.77). Multiple regression analysis showed that the prevalence of below median scores was higher in older women and in those with insomnia. Having a sexual partner and feeling well was associated with a protective effect against a below median sexuality score. In women with sexual partner, the prevalence of below median scores was higher in women who lived with their sexual partner, were in the menopausal transition or postmenopausal and in hypertensive women. Sexual activities involving penetration and a score of 6 for satisfaction with partner as a lover were indicative of a protective effect against below median sexuality score. Conclusions: Older women and those with insomnia were more likely to have a bad sexuality, whereas the ones with a sexual partner and who felt well were more likely to have a good sexuality. In the group which had sexual partner, the sexuality of women in midlife was negatively associated with the fact of living with a sexual partner, being in the menopausal transition or postmenopausal and being hypertensive. Satisfaction with the sexual partner as a lover and having sexual activities with penetration decreased the chance of poor sexuality
Doutorado
Tocoginecologia
Mestre em Tocoginecologia
Borges, Pítia Cárita de Godoy [UNESP]. "Correlação ultrassonográfica e histeroscópica no diagnóstico de pólipos endometriais em mulheres na pós-menopausa." Universidade Estadual Paulista (UNESP), 2010. http://hdl.handle.net/11449/99249.
Full textCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Para o diagnóstico de pólipo endometrial, dispõe-se da ultrassonografia e da histeroscopia ambulatorial, sendo a última considerada padrão ouro. A ultrassonografia avalia a espessura do endométrio, sua alteração de ecogenicidade e seus limites. Os resultados de tal exame pode sugerir a doença. A histeroscopia ambulatorial, por sua vez, é um exame mais preciso, pois permite uma melhor identificação do pólipo endometrial. Além disso, ela permite a confirmação do diagnóstico através da biópsia, assim como o tratamento. Comparar a ultrassonografia e a histeroscopia ambulatorial como métodos propedêuticos dos pólipos endometriais nas mulheres menopausadas do Serviço de Endoscopia Ginecológica e Planejamento Familiar da Disciplina de Ginecologia do Departamento de Ginecologia e Obstetrícia da Faculdade de Medicina de Botucatu–Hospital das Clínicas (UNESP). Estudo analítico e retrospectivo cujos dados foram obtidos através de consultas a 323 prontuários de mulheres menopausadas submetidas a ultrassonografia e a histeroscopia ambulatorial no referido setor, no período de março de 2003 a março de 2009. Foram incluídas no estudo 281 mulheres menopausadas na faixa etária de 41 a 82 anos, que haviam sido submetidas à histeroscopia ambulatorial por apresentarem sangramento uterino e/ou ultrassonografia transvaginal alterada (EE≥5 mm), e que, por esses motivos, foram encaminhadas ao ambulatório. A idade média das pacientes foi de 61,3 anos, sendo que 27,6% apresentaram diabetes mellitus tipo II, 70,5% eram hipertensas, 5,7% eram tabagistas. A média do índice de massa corpórea (IMC) foi de 31,6 kg/m2, e 73% eram multíparas (com 3 ou mais partos). A média do tempo de menopausa (amenorreia) foi de 10,7anos, sendo que 15,3% das pacientes eram usuárias de terapia hormonal, e 6,8% estavam em tratamento de câncer de mama com tamoxifeno. Do total de pacientes, 38,1%...
Ultrasonography and outpatient hysteroscopy are considered the “golden standard” for the diagnostic of endometrial polyp. Ultrasonography evaluates the endometrial thickness, the echogenicity and the limits. Its results can suggest the pathology. Outpatient hysteroscopy, on the other hand, is a more accurate exam, providing a better identification of the endometrial polyp and confirming the diagnostic through histological examination. It also may be used as a treatment. Comparison of the ultrasonography with the outpatient hysteroscopy as diagnostic methods for endometrial polyps in postmenopausal women from the Endoscopic and Gynecologic Service of the Medical School of Botucatu – UNESP. Analytical and retrospective study based on the files of 323 postmenopausal women submitted to ultrasonography and to outpatient hysteroscopy from March 2003 to March 2009, wich were performed in the Gynecologic and Obstetric Department of the Medical School of Botucatu (UNESP) – Gynecology Discipline of Botucatu Medical School. In this study, 281 postmenopausal women, with ages between 41 and 82 years, and that had been submitted to outpatient diagnostic hysteroscopy, were included. They had uterine bleeding and/or altered transvaginal ultrasound (EE≥5 mm). Patients mean age was 61,3 years; 27,6% had diabetes mellitus II; 70,5% had systemic arterial hypertension; and 5,7% were smokers. IMC was 31,6 kg/m2, and 73% were multiparae (3 or more deliveries). Average menopause time (amnorrhea) was 10,7 years; 15,3% were under hormonal therapy; and 6,8% were under breast cancer treatment with taximofen. From the 323 patients, 38,1% had uterine bleeding and 61,9% were asymptomatic. Ultrasonography detected endometrial polyp in 22,8% of the patients, endometrial thickness in 59,8%, being 10,5mm the mean thickeness. Comparing the ultrasonography with the histopathology, it was observed that endometrial... (Complete abstract click electronic access below)
Orsatti, Fábio Lera. "Efeito da isoflavona da soja e treinamento resistido sobre a composição corporal e densidade mineral óssea em mulheres na pós-menopausa /." Botucatu : [s.n.], 2008. http://hdl.handle.net/11449/106384.
Full textAbstract: To investigate the independent and additive effects of resistance training (RT) and soy isoflavone (ISO) on bone mineral density (BMD) and body composition in postmenopausal women. This study used a placebo-controlled, double-blind (soy), randomized two (ISO vs placebo) x two (RT vs no-RT) design. A total of 80 sedentary postmenopausal women (>12 months amenorrhea and FSH >40mIU/ml), aged 45- 70 years, was randomized one of four groups (71 completed 9-months intervention): ISO + RT (n=15; 55.7±7.0); ISO + no-RT (n=20; 56.6±8.8); placebo + RT (n=18; 56.0±5.8); placebo + no-RT (n=18; 55,3±8,0). Participants randomized to ISO received 250mg of standardized soy extract, total of 100mg/day of isoflavone. Subjects randomized to RT attended supervised resistance exercise sessions, three days/week for 9-months and included 2-3 exercises for the larger muscle groups, and 1 exercise for smaller groups in 3 series of 8-12 repetitions. At baseline and 9-months, body composition (fat and muscle mass) and BMD (whole body, lumbar spine and femoral neck) were estimated by dual-energy x-ray absorptiometry (DXA, Hologic QDR-2000). Serum levels of C-terminal cross-linked telopeptides of type I collagen (CTX) and osteocalcin were measured as markers of bone resorption and formation, respectively. The anthropometric indicators included: weight, height, body mass index (BMI= weight/height2), waist circumference (WC) and waist/hip ratio (WHR). The plasma levels of isoflavones were measured to assess compliance. The Shapiro-Wilk, Kolmogorov & Smirnov for distribution statistics, and Levene's test for homogeneity of variances, ANOVA-repeated measure, ANOVAone way and post hoc Fisher test, Pearson's correlation, test t and analyze regression forward stepwise were used in the statistical analysis. There were no significant difference... (Complete abstract click electronic access below)
Orientador: Eliana Aguiar Petri Nahás
Coorientador: Jorge Nahás Neto
Banca: Nailza Maestá
Banca: Leone A. Simonetti
Banca: Cesar Eduardo Fernandes
Banca: Aarão Mendes Pinto Neto
Doutor
Stephan, Cristina. "Associação entre a densidade mineral óssea da coluna lombar e do fêmur e do perfil lipídico e lipoprotéico em pacientes pós-menopáusicas com osteoporose /." Botucatu : [s.n.], 2006. http://hdl.handle.net/11449/95372.
Full textBanca: César Eduardo Fernandes
Banca: Eliana Aguiar Petri Nahás
Banca: Sérgio Peixoto
Resumo: O objetivo deste estudo foi avaliar a associação entre a densidade mineral óssea da coluna lombar e do fêmur e o perfil lipídico e lipoprotéico em pacientes pósmenopáusicas com osteoporose. Foram avaliadas 351 pacientes com média etária de 64,4 anos, em estudo de corte transversal. Foram analisadas as correlações entre a densidade mineral óssea da coluna lombar e as distintas variáveis do perfil lipídico e lipoprotéico. Iguais correlações também foram estudadas em relação à densidade mineral óssea do colo do fêmur. Levou-se em conta para as referidas análises o tempo de pós-menopausa e o índice de massa corporal das pacientes. Ao final, pode-se concluir pela existência de associação significativa entre os níveis plasmáticos de HDLC e a presença de osteoporose do colo do fêmur somente nas pacientes com mais de 10 anos de pós-menopausa. Estas apresentaram níveis plasmáticos de HDL-C significativamente mais elevados. Não houve associação entre a densidade mineral óssea do colo do fêmur e as demais variáveis do perfil lipídico e lipoprotéico (CT, LDL-C e TG). Também não houve associação entre a densidade mineral óssea da coluna vertebral e as variáveis analisadas do perfil lipídico e lipoprotéico (CT, LDL-C, HDL-C e TG)
Abstract: The aim of this study was to analyze the association between the bone mineral density (BMD) in the lumbar spine and hip and the lipid and lipoprotein profile in post-menopause women with osteoporosis. A sectional study was performed with 351 women. Their mean age was 64,4 years. We performed a linear correlation between the lumbar spine BMD and the variables of the lipid and lipoprotein profile (CT: total cholesterol; HDL-C: high lipoprotein density; LDL-C: low lipoprotein density; TG: tryglicerides). The same procedure was done with the hip BMD. We also analized the time since menopause and bone mass index. In the end of the study we concludes that there was a significant association between HDL-C plasmatic levels in the hip only in women with more than 10 years since menopause. They had HDL-C plasmatic levels signifcantly higher. There wasnþt an association between the hip BMD and the other lipid and lipoprotein variables (CT, LDL-C,TG). Also, there wasnþt an association between the lumbar spine BMD and the lipid and lipoprotein variables (CT, HDL-C, LDl-C, TG)
Mestre
Kelly, Jennifer Mary. "Lesbians' experiences of menopause." Connect to this title online, 2003. http://tux.lib.deakin.edu.au/adt-VDU/public/adt-VDU20050825.105816/.
Full textKelly, Jennifer Mary, and mikewood@deakin edu au. "Lesbians' experiences of menopause." Deakin University. School of social and International Studies, 2003. http://tux.lib.deakin.edu.au./adt-VDU/public/adt-VDU20050825.105816.
Full textLee, Cheuk-kiu Kathy. "Menopause and cognitive functionings." Click to view E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B3710181X.
Full text李卓翹 and Cheuk-kiu Kathy Lee. "Menopause and cognitive functionings." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B3710181X.
Full textOrru, A. J. "Vulvovaginal atrophy during menopause." Thesis, Sumy State University, 2017. http://essuir.sumdu.edu.ua/handle/123456789/58732.
Full textHägg, Fanny. "Evolutionary Theories of Menopause." Thesis, Linköpings universitet, Institutionen för fysik, kemi och biologi, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-167618.
Full textNordgren, Lisa. "Don't pause for menopause." Thesis, Malmö högskola, Fakulteten för kultur och samhälle (KS), 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-21464.
Full textDue to gender norms, the general attitude towards menopause in today’s society is negative. The majority of available methods to ease menopause symptoms are medical alternatives and the ones who choose not to use those, for different reasons, are left without an option.This study examined how product design can be used to ease menopausal related problems and contribute to put focus on menopause. The purpose was to make menopause more visible and by that contribute to a positive attitude towards it. The overarching goal was to develop a proposal for a product achieving that. The study relies on a theoretical foundation of gender studies, a historical view of gynecology and perception of women, norm criticism, norm creativity, norm creative design and human-centered design. The empirical evidence consisted mainly of interviews and discussions with representatives from the target group (people with menopausal related problems) and market research of existing menopausal products.The conclusion of the study shows that for making it possible for a product to both ease menopausal problems and make menopause more visible it needs to fulfil three criteria; in a way practically ease the symptoms, be eye-catching and be something the target group are comfortable using around other people. The product that has been developed in this study is only to be considered as one of many possible solutions since there is no correct answer to how a menopausal product should look or function. By moving beyond the norms, that usually control how menopausal problems are treated, it is possible to develop new and innovative alternatives.
Rodrigues, Edna Talarico. "Avaliação do efeito da isoflavona sobre o epitélio cérvico-vaginal e sintomas da menopausa." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/60/60135/tde-03042009-115328/.
Full textThe lack of estrogens characterizes postmenopausal condition and is associated with pathological conditions and symptoms, including atrophic vaginites, osteoporosis and cardiovascular disease. Hormone replacement therapy is recommended for postmenopausal women but there are contraindications and side effects. There are many alternative therapy researches in order to alleviate these symptoms. Soy isoflavone has hormonal effects in postmenopausal women, by binding a common phenolic structure to estrogens receptors. The aim of this study focusing isoflavone, extracted from soy beans Glycine max, was to evaluate the effects of isofavone on vaginal cytology, vaginal maturation index (M.I.), maturation value (M.V.), vaginal microbiota and menopausal symptoms. This study involved 49 postmenopausal women, a randomized double blind placebo controlled. The first group of 23 women was treated with 40 mg/day capsule of placebo (caseyne) and the second group of 26 women was treated with 40 mg/day capsule of isoflavone. Urine and vaginal samples for 3 slides: colpocytogram, wet sample colpocytogram, Gram-stained smears was taken at baseline and after treatment in order to determine M.I., M.V., vaginal microbiological findings and colpocytologic findings. Study participants answered an in-person interview with questions in order to determine menopausal symptoms, complains, menopause perception, sexual life, general health to determine, for instance the Kuppermann menopausal index (KMI) at baseline, every month and after six-months of treatment. The M.I. from traditional colpocytogram reduced significantly the parabasal cells (P=0,003), increased significantly the percentage of Superficial Cianophilic cells (P=0,006), there was a tendence of increasing the Superficial Eosinofilic cells (P=0,18). From wet sample colpocytogram, similar results were obtained: reduced significantly the parabasal cells (P=0,004), increased significantly the percentage of Superficial Cianophilic cells (P=0,008) there was a tendence of increasing the Superficial Eosinofilic cells (P=0,18).. In urocytogram, the results obtained were: reduced significantly the parabasal cells (P=0,008), increased significantly the percentage of Superficial Cianophilic cells (P=0,013), increase of Superficial Eosinofilic cells (P=0,002). For placebo group there were no significative changes. The Maturation Value, M.V. increased significtively (P=0,007) in traditional colpocytogram; in wet sample colpocytogram (P=0,004) and in urocytogram (P=0,0008), comparing with placebo was observed significant decrease (P=0,02) for M.V. After treatment with isoflavone there was significative increase of Döederlein bacillus (P=0,005), decrease of 19,3% in cases of bacterial vaginosis (Nugent score) and decrease of others pathogenic microbial agents. The symptoms decreased significatively in woman treated with placebo and decreased significatively in women treated with isoflavone.
Gourley, Catherine Anne Caldwell. "Alternative discourse on menopause : an examination of the decision-making processes of women regarding menopausal concerns /." Full text (PDF) from UMI/Dissertation Abstracts International, 2001. http://wwwlib.umi.com/cr/utexas/fullcit?p3008340.
Full textBorges, Pítia Cárita de Godoy. "Correlação ultrassonográfica e histeroscópica no diagnóstico de pólipos endometriais em mulheres na pós-menopausa /." Botucatu, 2010. http://hdl.handle.net/11449/99249.
Full textBanca: Jorge Nahas Neto
Banca: Reginaldo Guedes Coelho Lopes
Resumo: Para o diagnóstico de pólipo endometrial, dispõe-se da ultrassonografia e da histeroscopia ambulatorial, sendo a última considerada padrão ouro. A ultrassonografia avalia a espessura do endométrio, sua alteração de ecogenicidade e seus limites. Os resultados de tal exame pode sugerir a doença. A histeroscopia ambulatorial, por sua vez, é um exame mais preciso, pois permite uma melhor identificação do pólipo endometrial. Além disso, ela permite a confirmação do diagnóstico através da biópsia, assim como o tratamento. Comparar a ultrassonografia e a histeroscopia ambulatorial como métodos propedêuticos dos pólipos endometriais nas mulheres menopausadas do Serviço de Endoscopia Ginecológica e Planejamento Familiar da Disciplina de Ginecologia do Departamento de Ginecologia e Obstetrícia da Faculdade de Medicina de Botucatu-Hospital das Clínicas (UNESP). Estudo analítico e retrospectivo cujos dados foram obtidos através de consultas a 323 prontuários de mulheres menopausadas submetidas a ultrassonografia e a histeroscopia ambulatorial no referido setor, no período de março de 2003 a março de 2009. Foram incluídas no estudo 281 mulheres menopausadas na faixa etária de 41 a 82 anos, que haviam sido submetidas à histeroscopia ambulatorial por apresentarem sangramento uterino e/ou ultrassonografia transvaginal alterada (EE≥5 mm), e que, por esses motivos, foram encaminhadas ao ambulatório. A idade média das pacientes foi de 61,3 anos, sendo que 27,6% apresentaram diabetes mellitus tipo II, 70,5% eram hipertensas, 5,7% eram tabagistas. A média do índice de massa corpórea (IMC) foi de 31,6 kg/m2, e 73% eram multíparas (com 3 ou mais partos). A média do tempo de menopausa (amenorreia) foi de 10,7anos, sendo que 15,3% das pacientes eram usuárias de terapia hormonal, e 6,8% estavam em tratamento de câncer de mama com tamoxifeno. Do total de pacientes, 38,1%... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: Ultrasonography and outpatient hysteroscopy are considered the "golden standard" for the diagnostic of endometrial polyp. Ultrasonography evaluates the endometrial thickness, the echogenicity and the limits. Its results can suggest the pathology. Outpatient hysteroscopy, on the other hand, is a more accurate exam, providing a better identification of the endometrial polyp and confirming the diagnostic through histological examination. It also may be used as a treatment. Comparison of the ultrasonography with the outpatient hysteroscopy as diagnostic methods for endometrial polyps in postmenopausal women from the Endoscopic and Gynecologic Service of the Medical School of Botucatu - UNESP. Analytical and retrospective study based on the files of 323 postmenopausal women submitted to ultrasonography and to outpatient hysteroscopy from March 2003 to March 2009, wich were performed in the Gynecologic and Obstetric Department of the Medical School of Botucatu (UNESP) - Gynecology Discipline of Botucatu Medical School. In this study, 281 postmenopausal women, with ages between 41 and 82 years, and that had been submitted to outpatient diagnostic hysteroscopy, were included. They had uterine bleeding and/or altered transvaginal ultrasound (EE≥5 mm). Patients mean age was 61,3 years; 27,6% had diabetes mellitus II; 70,5% had systemic arterial hypertension; and 5,7% were smokers. IMC was 31,6 kg/m2, and 73% were multiparae (3 or more deliveries). Average menopause time (amnorrhea) was 10,7 years; 15,3% were under hormonal therapy; and 6,8% were under breast cancer treatment with taximofen. From the 323 patients, 38,1% had uterine bleeding and 61,9% were asymptomatic. Ultrasonography detected endometrial polyp in 22,8% of the patients, endometrial thickness in 59,8%, being 10,5mm the mean thickeness. Comparing the ultrasonography with the histopathology, it was observed that endometrial... (Complete abstract click electronic access below)
Mestre
Pereira, Elaine Cri. "Distúrbios do sono em mulheres na transição menopausal e pós-menopausa." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/6/6136/tde-17082015-134324/.
Full textObjective - Estimate the incidence of sleep disorders and identify theirs risk factors in women without trouble sleeping this was the first step Pindamonhangaba Health Project (PROSAPIN) conducted in 2007. Methodology It was consist of in the second stage of PROSAPIN project realized on 21 units of the Family Health Strategy 1,200 women between 35 to 72 age was divided with brand new volunteers (chosen in 2014) and old (volunteers PROSAPIN 2007). They were surveyed by questionnaire the following sleep disorders:1) poor sleep by the Pittsburgh Sleep Quality Index; 2) insomnia, by the questionnaire Pittsburgh;3) excessive daytime sleepiness, the Epworth Sleepiness Scale and 4) obstructive sleep apnea, by Berlin Questionnaire. As independent socio demographic characteristics were investigated; gynecological history; presence of comorbidities; emotional symptoms, climatic and musculoskeletal; lifestyle; use of medications; anthropometric measurements and blood tests. These analysis, were performed for Stata version 11.0, were a)estimate the prevalence of sleep disorders separate for type during the year of 2014b) compare the prevalence studies between 2007 and 2014 c) identification of factors associated with prevalence of sleep disorders in 2014; d) estimate the incidence of sleep disorders during the year of 2014 and their risks factors. Results- The incidence of sleep disorders in seven years was 75.0 per cent and the risk factors were the triglycerides 150 mg / dl and waist circumference 100.5 cm; as protection, HDL 50 mg / dl and schooling 1 high school. The prevalence rates in 2007 and 2014 were as follows: sleep disorders in general 63.4 per cent and 82.7 per cent ; poor sleep 45.1 per cent and 54.9 per cent ; insomnia 13.3 per cent and 19.0 per cent ; EDS 23.1 per cent and 24.1 per cent and obstructive sleep apnea 25.1 per cent and 60.5 per cent . Factors associated with the prevalence of sleep disorders in 2014 were a risk to intense anxiety, stress reported, the use of antidepressants and glucose> 100 mg / dl, as protective factors be considered retired and physically very active. Conclusion - The incidence of sleep disorders in seven years was high and their risk factors were metabolic. Comparison of the prevalence of two points, 2007 and 2014 Showed a significant Increase in sleep disorders.
Nelson, Marian. "The menopause : another maternal strategy?" Thesis, University of Liverpool, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415651.
Full textPokoradi, Alida Jennifer. "Long-term sequelae of menopause." Thesis, University of Aberdeen, 2012. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=192389.
Full textLunn, Sarah. "Female menopause : a male perspective." Thesis, University of East London, 2000. http://roar.uel.ac.uk/3651/.
Full textGUEYDAN, COLIN MADELEINE. "Femmes en menopause, nouvelle temporalite." Montpellier 3, 1991. http://www.theses.fr/1991MON30006.
Full textWithin a woman's life, 50 years old is time to understand feminity, in other words time for a working-through. Clinical cases allos us to advance that after the period of mourning, of procreation, of beauty, of youth, new issues centered on sublimation work do appear. But this mourring, when it can't be, leads ,to nervous breakdown and melancholy, leaving the women dependant upon the death instinct. The creative drive which until there was invested in the maternel function may suddendly reappear in order to fulfill personal wishes which were delayted for the benefit of mariage and motherhood
MERTZ, ANNE-CATHERINE. "Risque cardio-vasculaire lie a la menopause et au traitement hormonal substitutif de la menopause." Strasbourg 1, 1992. http://www.theses.fr/1992STR15056.
Full textOrsatti, Fábio Lera [UNESP]. "Efeito da isoflavona da soja e treinamento resistido sobre a composição corporal e densidade mineral óssea em mulheres na pós-menopausa." Universidade Estadual Paulista (UNESP), 2008. http://hdl.handle.net/11449/106384.
Full textCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Investigar o efeito independente e aditivo do treinamento resistido (TR) e da isoflavona de soja (ISO) sobre a densidade mineral óssea (DMO) e a composição corporal de mulheres na pós-menopausa. Foi conduzido estudo clínico prospectivo, duplo-cego (ISO), placebocontrolado e randomizado dois (ISO x Placebo) por dois (TR x sem TR). Oitenta mulheres sedentárias na pós-menopausa (amenorréia últimos 12 meses, FSH > 40UIml), idade entre 45 a 70 anos, foram randomizadas a um dos quatro grupos (71 completaram 9 meses de intervenção): ISO + TR (n=15; 55,7±7,0); ISO + sem TR (n=20; 56,6±8,8); placebo + TR (n=18; 56,0±5,8); placebo + sem TR (n=18; 55,3±8,0). As participantes randomizadas para ISO receberam 250mg de extrato de soja, total de 100mg/dia de isoflavona. Aquelas randomizadas para TR realizaram sessões de exercícios resistidos supervisionados, mínimo de dois dias na semana, durante 9 meses, que incluiu 2-3 exercícios para os grupamentos musculares maiores (coxa, peito e costa) e 1 exercício para os menores (bíceps e tríceps), em 3 séries de 8-12 repetições máximas. No momento basal e aos 9 meses, a composição corporal (massa gordurosa e muscular) e a DMO (corpo inteiro, colo de fêmur e coluna lombar) foram estimadas pela absortometria radiológica de feixes duplos de energia (DXA, Hologic QDR-2000). Valores plasmáticos de CTX (serum levels of C-terminal cross-linked telopeptides of type I collagen) e de osteocalcina foram dosados como marcadores da reabsorção e formação óssea, respectivamente. Para avaliação antropométrica foram obtidos: peso, estatura, índice de massa corpórea (IMC=peso/altura2), circunferência da cintura (CC) e relação cintura/quadril (RCQ). Valores plasmáticos de isoflavona foram realizados ao final da intervenção para analisar a aderência ao tratamento. Na análise...
To investigate the independent and additive effects of resistance training (RT) and soy isoflavone (ISO) on bone mineral density (BMD) and body composition in postmenopausal women. This study used a placebo-controlled, double-blind (soy), randomized two (ISO vs placebo) x two (RT vs no-RT) design. A total of 80 sedentary postmenopausal women (>12 months amenorrhea and FSH >40mIU/ml), aged 45- 70 years, was randomized one of four groups (71 completed 9-months intervention): ISO + RT (n=15; 55.7±7.0); ISO + no-RT (n=20; 56.6±8.8); placebo + RT (n=18; 56.0±5.8); placebo + no-RT (n=18; 55,3±8,0). Participants randomized to ISO received 250mg of standardized soy extract, total of 100mg/day of isoflavone. Subjects randomized to RT attended supervised resistance exercise sessions, three days/week for 9-months and included 2-3 exercises for the larger muscle groups, and 1 exercise for smaller groups in 3 series of 8-12 repetitions. At baseline and 9-months, body composition (fat and muscle mass) and BMD (whole body, lumbar spine and femoral neck) were estimated by dual-energy x-ray absorptiometry (DXA, Hologic QDR-2000). Serum levels of C-terminal cross-linked telopeptides of type I collagen (CTX) and osteocalcin were measured as markers of bone resorption and formation, respectively. The anthropometric indicators included: weight, height, body mass index (BMI= weight/height2), waist circumference (WC) and waist/hip ratio (WHR). The plasma levels of isoflavones were measured to assess compliance. The Shapiro-Wilk, Kolmogorov & Smirnov for distribution statistics, and Levene's test for homogeneity of variances, ANOVA-repeated measure, ANOVAone way and post hoc Fisher test, Pearson’s correlation, test t and analyze regression forward stepwise were used in the statistical analysis. There were no significant difference... (Complete abstract click electronic access below)
Kantoviscki, Andréia Lara Lopatko. "A vivência do processo de menopausa para mulheres: uma contribuição para a enfermagem." Universidade do Estado do Rio de Janeiro, 2010. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2705.
Full textThey is esteem that, in the year of 2025, 23% of the total population of the developed countries will be with more than 60 years, what show the gradual aging of the population contingent of these countries. In this way, is perceivable the contingent of women who will be living deeply the phase of the menopause with its biological, psychological and social effects. The physiological and chemical changes that happen in the women during the menopauses phase, followed with the aesthetic depreciation of the body, have been interpreted as loss of the feminine characteristics, signaling the inevitable aging and the end of the life. However, many of the discomforts that the women live in this phase not must to the biological changes, but to its process of socialization, characterizing the genre influence. In this context, this work had as object the study of the influence of the relation of genre in the experience and meaning of the process of the menopause, having as objective: describes the experience of the menopause on the perspective of women and to identify the particularitities involved to the genre in the experience of the menopause on the perspective of the women. For development of the work, was done one research descriptive-qualitative with customers of the Basic Units of Health of the city of Curitibanos-SC, in the period of 1 to 15 of October of 2009. For the collect of data, one structured interview was used with an orienting question: It speaks to me, as are for you to be living the menopause. The interviews were done with 20 women, with ages between 45 and 55 years and that had presented spontaneous menopause. The interpretation and analysis was done by analysis of content of the thematic type described by Bardin. In the narratives, was done the identification of categories that was integrated in four main subjects: Living on the Menopause, Identifying Transformations in the Woman Body and in the Life, Cares Myself, Research Information/Influences and Building Knowledge. Was possible identify in these categories that the women bring the idea that the menopause phase is an illness, and relate this phase with aging and physical decline, which brings great sufferings, what it demonstrates to the influence of genre in this phase. The interviewed ones showed diverse symptoms in its words, this bother and intervene in the daily activities and its way to be, and this situation, influence many times in its familiar and professional behavior. The knowledge on the menopause, in this group of women, was constructed throughout its lives and reflects its cultural and social realities, leaving evident the scarcity of information sources and the taboos related with the subject. This work improve of knowledge in consideration the effect that the genre influence can have in the experience and perception of the menopause, demystifying the experience mode of the women during this period, not conditioning for stereotypes and beliefs related to the genre.
Giorno, Cecilia Del. "Efeitos do Trifolium pratense nos sintomas da menopausa e na satisfação sexual em mulheres climatéricas." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-22022010-170555/.
Full textObjective: to evaluate the effects of Trifolium pratense treatment on the climacteric symptoms and sexualiy in postmenopausal women through Kuppermann Menopausal Index (KMI) and the Golombok Rust Inventory of Sexual Satisfaction (GRISS), respectively. Methods: This study was prospective, randomized, double-blind and placebo-controlled study. Hundred women were selected, aged between 45 and 65 years with climacteric symptoms, with menstruation absence (amenorrhea) that was more then one year and without any treatment for last six months. After selection, women were divided into two groups: GI (n = 50) received 40 mg Trifolium pratense (one capsule per day); GII (n = 50) received placebo (control, one capsule of lactose per day). The length of treatment was 12 months and women were evaluated before and after four, eight and twelve months of treatment through clinical and laboratorial exams. The t Student test and ANOVA were applied for analyzing the differences between groups. Results: There was significant ameliorate in the symptoms after four months of treatment through the KMI, mainly in hot flashes, compared to baseline data of both groups. The sexuality evaluation did not found any difference before and after treatment in both groups. Conclusion: Our data suggested that the 40 mg Trifolium pratense effect may be not superior than placebo in relation to decrease the postmenopausal symptoms during one year of study
Mvundura, Mercy. "Menopause Transition and Labor Market Outcomes." Digital Archive @ GSU, 2007. http://digitalarchive.gsu.edu/econ_diss/38.
Full textLORCY, DANIEL. "La menopause mythique de jean brodie." Nantes, 1986. http://www.theses.fr/1986NANT3011.
Full textThis ph. D dissertation is a detailed study of jean brodie, the character that gave its name to the novel. This study enables us to understand better the writer, muriel spark, in these two aspects which are most important in the art of the novelist: her assertion of her catholic belief and the capital importance to her, of another world more real than ours : the world of the eternal life. It is because jean brodie will only put forward the world of the senses in her life and in her teaching, that she will be condemned by the author. So this menopause that jean brodie wanted to transform into a legend, a myth, will only be a trivial oldage
Bremer, Eleanor. "Anxiety in Menopause: A Qualitative Inquiry." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5315.
Full textRubinstein, Helena. "The meanings of menopause : identifying the bio-psycho-social predictors of the propensity for treatment at menopause." Thesis, University of Cambridge, 2013. https://www.repository.cam.ac.uk/handle/1810/245082.
Full textButtros, Daniel de Araújo Brito [UNESP]. "Síndrome metabólica em mulheres na pós-menopausa tratadas de câncer de mama." Universidade Estadual Paulista (UNESP), 2012. http://hdl.handle.net/11449/93095.
Full textFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Avaliar o risco de síndrome metabólica (SM) em mulheres na pós-menopausa tratadas de câncer de mama, comparadas às mulheres na pós-menopausa sem câncer de mama. Realizou-se estudo clínico, analítico e transversal, com 104 mulheres tratadas de câncer de mama comparadas a 208 mulheres na pós-menopausa (controle), atendidas em Hospital Universitário. Foram incluídas no grupo de estudo mulheres com amenorréia >12 meses e idade ≥45 anos, tratadas de câncer de mama e livre de doença há pelo menos cinco anos. O grupo controle foi constituído de mulheres com amenorréia >12 meses e idade ≥45 anos sem câncer de mama, pareadas pela idade, na proporção 1:2. Por meio de entrevista foram coletados dados clínicos e antropométricos. Na análise bioquímica foram solicitadas dosagens de colesterol total (CT), HDL, LDL, triglicerídeos (TG), glicemia e proteína C-reativa (PCR). Foram consideradas com SM as mulheres que apresentaram três ou mais critérios diagnósticos: circunferência da cintura (CC) > 88 cm; TG ≥ 150 mg/dL; HDL colesterol < 50 mg/dL; pressão arterial ≥ 130/85 mmHg; glicemia de jejum ≥ 100 mg/dL. Para análise estatística foram empregados o teste t-student, o teste do Qui-Quadrado e a regressão logística (odds ratio-OR). A média de idade da pacientes tratadas de câncer de mama foi de 60,6 ± 8,6 anos com tempo médio de seguimento de 9,4 ± 4,4 anos. Maior porcentagem de pacientes tratadas de câncer de mama (46,2%) era obesa quando comparadas ao controle (32,7%) (p<0,05). E menor porcentagem de mulheres tratadas de câncer apresentou valores considerados ótimos de LDL, glicemia e PCR quando comparadas ao controle (p<0,05). A SM foi diagnosticada em 50% das mulheres tratadas de câncer de mama e 37,5% no grupo controle (p<0,05). Entre os critérios...
To assess the risk of metabolic syndrome (MetS) in postmenopausal women breast cancer survivors compared to postmenopausal women without breast cancer. In this cross-sectional study, 104 women breast cancer survivors were compared with 208 postmenopausal women (control), seeking healthcare at a University Hospital. Eligibility criteria included women with amenorrhea > 12 months and age ≥ 45 years, treated for breast cancer and no recorrences for at least five years. The control group consisted of women with amenorrhea >12 months and age ≥ 45 years without breast cancer matched by age, in proportion 1:2. Dates on clinical antecedents and anthropometric indicators were collected. The biochemical parameters, including total cholesterol, HDL, LDL, triglycerides, glucose and C-reactive protein (CRP), were measured. MetS was diagnosed as the presence of at least three components among: waist circumference (WC) >88cm, blood pressure ≥130/85mmHg, triglycerides ≥150mg/dl, HDL <50mg/dl and glucose ≥100mg/dl. For statistical analysis were used: Student t-test, Chi-square test, and logistic regression method (odds ratio-OR). The mean age of women breast cancer survivors was 60.6 ± 8.6 years with a mean follow-up of 9.4 ± 4.4 years. A higher percentage of women breast cancer survivors (46.2%) were obese compared to control (32.7%) (p <0.05). And a smaller percentage of women breast cancer survivors had optimal values of LDL, glucose and CRP compared to controls (p <0.05). MetS was diagnosed in 50% of women breast cancer survivors and 37.5% in the control group (p <0.05). The most prevalent diagnostic criteria of MetS was abdominal obesity (WC> 88 cm) affecting 62.5% of women breast cancer survivors and 67.8% of control group. Women breast cancer survivors had a higher risk for metabolic syndrome... (Complete abstract click electronic access below)
Cangussu, Luciana Mendes [UNESP]. "Avaliação do equilíbrio postural em mulheres na pós-menopausa e sua relação com a densidade mineral óssea." Universidade Estadual Paulista (UNESP), 2011. http://hdl.handle.net/11449/99189.
Full textCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Avaliar a associação entre o equilíbrio postural e a densidade mineral óssea (DMO) em mulheres na pós-menopausa e correlacionar com o risco de quedas. Realizou-se estudo de corte transversal com 225 mulheres, idade 45-75 anos, atendidas em Hospital Universitário. Incluíram-se mulheres em amenorréia >12 meses e idade ≥ 45 anos, com valores de DMO (coluna lombar e colo de fêmur) pelo DXA, dos últimos 12 meses. E se excluíram aquelas com doenças neurológicas ou musculoesqueléticas, história atual de vestibulopatias, déficit visual sem correção, obesidade grau III e usuárias de drogas que alterem o equilíbrio. As mulheres foram divididas segundo a DMO em > -2,0 DP (n=140) e ≤ -2 DP (n=85). Foram analisados o histórico de quedas (últimos 24 meses) e as características clínicas e antropométricas. O equilíbrio postural foi avaliado pela estabilometria (plataforma de força), teste de Romberg, alcance funcional e teste do agachamento. Para análise estatística foram empregados o Teste de Wilcoxon para variáveis quantitativas, o teste do Qui-Quadrado ou Exato de Fisher para variáveis categóricas e o método de regressão logística para o risco de quedas (Odds Ratio-OR). As pacientes com DMO > -2,0 DP eram mais jovens e com menor tempo de menopausa, assim como apresentavam maior IMC e circunferência da cintura quando comparadas aquelas com baixa DMO (≤ -2 DP) (p<0,05). Observou-se que 57,8% (130/225) das participantes relataram episódio de queda nos últimos dois anos, sem diferença significativa na distribuição percentual entre os grupos (p=0,055). Nos parâmetros estabilométricos e no alcance funcional não foram demonstradas diferenças na comparação entre os grupos (p>0,05). No teste de Romberg notou-se aumento progressivo da positividade à medida que aumentava a dificuldade do teste, sendo observada diferença significante entre os grupos apenas com...
To analyze the association between postural balance and bone mineral density (BMD) in postmenopausal women and correlate it with risk for falls. A cross-sectional study was conducted on 225 women aged 45-75 years and cared for at a University Hospital. Women in amenorrhea >12 months and age ≥ 45 years, with BMD values (lumbar spine and femur neck) by DXA for the last 12 months, were included. Those with neurological or musculoskeletal disorders, current history of vestibulopathies, uncorrected visual deficit, level-III obesity or drug use that could affect balance were excluded. The women were divided, according to BMD, in > -2.0 DP (n=140) and ≤ -2 DP (n=85). Histories of falls (last 24 months) as well as clinical and anthropometric characteristics were evaluated. Postural balance was assessed by stabilometry (strength platform), Romberg’s test, functional reach test and the crouching test. For statistical analysis, Wilcoxon’s test was used for quantitative variables, the Chi-square or Fisher’s exact test for categorical variables and the logistic regression method for fall risk (Odds Ratio-OR). Patients with BMD > -2.0 DP were younger and had been menopausal for a shorter period of time; they also showed higher BMI and larger waist circumference as compared to those with low BMD (≤ -2 DP) (p<0.05). It was observed that 57.8% (130/225) of the participants reported fall episodes in the last two years, without significant difference in the percent distribution between the groups (p=0.055). No differences were found in the comparison between the groups (p>0.05) for stabilometric parameters or functional reach test. Concerning Romberg’s test, progressive positive increase was observed as the test difficulty increased, and significant difference between the groups was found only when the women kept their feet in a series and their eyes closed (p<0.05). When evaluating the ... (Complete abstract click electronic access below)
Netto, Claudia Cardoso. "Avaliação da biopotencia dos frutooligossacarideos (FOS) e da terapia de reposição hormonal (TRH) no metabolismo de calcio de ratas ovarectomizadas." [s.n.], 2005. http://repositorio.unicamp.br/jspui/handle/REPOSIP/256027.
Full textDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia de Alimentos
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Mestrado
Nutrição Experimental e Aplicada à Tecnologia de Alimentos
Mestre em Alimentos e Nutrição
Carmignani, Lucio Omar 1965. "Fitoestrogenios como alimento funcional no tratamento da sindrome climateria : ensaio clinico randomizado duplo-cego e controlado." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/313700.
Full textDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas
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Resumo: Objetivos: Comparar os efeitos da ingestão diária de um suplemento alimentar à base de soja, terapia hormonal (TH) de baixa dosagem e placebo sobre os sintomas menopausais psicológicos, somáticos e urogenitais em mulheres na pós-menopausa e avaliar os efeitos sobre os principais marcadores de risco cardiovascular. Métodos: Ensaio clínico randomizado, duplo-cego e controlado envolvendo 60 mulheres sintomáticas com tempo médio desde a menopausa de 4,1 anos, com idade entre 40 e 60 anos. Foram selecionadas e randomizadas em três grupos: um grupo recebeu um suplemento alimentar à base de soja (isoflavona 90mg/dia), outro grupo recebeu terapia hormonal de baixa dose (estradiol 1mg e acetato de noretisterona 0,5mg) e um grupocontrole que recebeu placebo, por um período de 16 semanas. Foi utilizado o Menopause Rating Scale (MRS) para avaliar as mudanças nos sintomas climatéricos no início e após 16 semanas de tratamento. Também foram avaliados o perfil lipídico, glicemia, índice de massa corpórea, pressão arterial e relação cintura-quadril em todas as participantes no início e final do tratamento. Com o intuito de avaliar os efeitos deste tratamento sobre os níveis hormonais endógenos, foi medida a concentração sérica do hormônio folículo-estimulante (FSH) e o 17'beta'-estradiol. A análise estatística foi realizada usando-se o teste do qui-quadrado, teste exato de Fisher, análise de co-variância, teste não paramétrico de Kruskal-Wallis, teste t de Student pareado, teste de Kruskal-Wallis (seguido por Mann-Whitney), teste de Wilcoxon pareado, teste ANOVA (seguido de Tukey) e teste não paramétrico de Kruskal-Wallis (seguido de Mann-Whitney). Resultados: os resultados mostraram uma diminuição da pontuação do MRS total, comparando-se o início e o final do tratamento em todos os grupos, não havendo diferença estatística entre eles. Houve uma melhora significativa dos sintomas somáticos (fogachos e queixas articulares/musculares) e urogenitais (secura vaginal) nos grupos TH e soja. Em relação aos sintomas psicológicos, não houve diferença entre os grupos estudados: todos apresentaram uma melhora semelhante. Após 16 semanas de intervenção, o colesterol total diminuiu em 11,3% e o LDL-colesterol diminuiu 18,6% apenas no grupo TH. As triglicérides, HDL-colesterol, glicemia, índice de massa corpórea, pressão arterial, e relação cintura-quadril não se alteraram durante o tratamento nos três grupos. O FSH diminuiu e o 17'beta'-estradiol aumentou apenas no grupo TH. Conclusões: Este estudo sugere que o tratamento com suplemento alimentar à base de soja pode ser uma terapia alternativa efetiva para os sintomas somáticos e urogenitais relacionados à menopausa. O suplemento alimentar à base de soja não mostrou efeito favorável significativo sobre os marcadores de risco cardiovascular quando comparados ao uso da TH
Abstract: Objectives: To compare the effects of daily ingestion of soy dietary supplement, low-dose hormone therapy (HT) and placebo on menopausal psychological, somatic and urogenital symptoms in postmenopausal women and to assess the effects on the main biomarkers of cardiovascular health. Methods: This was a double-blind, randomized and controlled intention-to-treat trial. Sixty healthy postmenopausal women, aged 40-60, 4.1 years mean time since menopause were recruited and randomly assigned to three groups: a soy dietary supplement group (isoflavone 90mg/day), a low-dose HT group (estradiol 1mg plus noretisterone acetate 0.5mg) and a placebo group. The Menopause Rating Scale (MRS) was used to assess change in menopausal symptoms at baseline and after 16 weeks of treatment. Lipid profile, glucose level, body mass index, blood pressure and abdominal/hip ratio were evaluated in all the participants at the baseline and after 16 weeks. To examine the effects of this regime on endogenous hormone levels, follicle-stimulating hormone (FSH) and 17 'beta'-estradiol were measured. Statistical analyses were performed using chi-square test, Fisher¿s exact test, repeated-measures analysis of co-variance, Kruskal-Wallis non-parametric test, paired Student¿s t test, Kruskal-Wallis test (followed by Mann-Whitney test), paired Wilcoxon test, ANOVA test (followed by Tukey test) and Kruskal-Wallis non-parametric test (followed by Mann-Whitney test). Results: The data showed decrease in MRS total score comparing baseline values and after 16 weeks in all of the groups, but without statistical difference among the groups. There was significant improvement in somatic (hot flashes and joint/muscle complaints) and urogenital (vaginal dryness) symptoms from baseline to after 16 weeks for both the HT and soy groups, compared with the placebo group. There was no difference among the studied groups concerning psychological symptoms: all three groups showed a similar improvement. After a 16 weeks intervention period, total cholesterol decreased 11.3% and LDLcholesterol decreased 18.6% in HT group, but in the soy dietary supplement and placebo groups it did not change. The values for triglycerides, HDL-cholesterol, glucose level, body mass index, blood pressure, and abdominal/hip ratio did not change over the time in all of the three groups. FSH decreased and 17'beta'-estradiol increased only in the HT group. Conclusions: This study suggests that a soy dietary supplement may be an effective alternative therapy for somatic and urogenital symptoms. The use of dietary soy supplement did not show a significant favorable effect on cardiovascular health biomarkers comparing with HT
Mestrado
Tocoginecologia
Mestre em Tocoginecologia
Baccaro, Luiz Francisco Cintra 1980. "Fatores associados à densidade mineral óssea de mulheres submetidas a transplante de fígado." [s.n.], 2010. http://repositorio.unicamp.br/jspui/handle/REPOSIP/313668.
Full textDissertação (mestrado) - Universidade Estadual de Campinas. Faculdade de Ciências Médicas
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Resumo: Objetivos: avaliar a massa óssea e os fatores associados em mulheres submetidas a transplante de fígado em acompanhamento no Ambulatório da Unidade de Transplante Hepático do Hospital das Clínicas da Faculdade de Ciências Médicas da Universidade Estadual de Campinas Sujeitos e Métodos: estudo de corte transversal com mulheres transplantadas hepáticas em acompanhamento no Ambulatório da Unidade de Transplante Hepático do Hospital das Clínicas da Faculdade de Ciências Médicas da Universidade Estadual de Campinas. Foram incluídas todas as mulheres que realizaram transplante hepático há pelo menos um ano e com idade igual ou superior a 35 anos. Foram identificadas 33 mulheres que preenchiam os critérios de inclusão. Dessas, 6 não responderam ao contato telefônico e 4 não quiseram participar, sendo o número final de mulheres participantes igual a 23. Foi realizada entrevista, sempre pelo mesmo pesquisador, onde foram obtidos dados clínicos, sócio-demográficos e realizados exame físico geral e ginecológico. Após a avaliação clínica as mulheres foram encaminhadas para realização de exames laboratoriais (aspartato aminotransferase, alanina aminotransferase, fosfatase alcalina, gama glutamiltransferase, bilirrubina total e frações) e densitometria óssea de coluna lombar e fêmur. A análise estatística foi realizada através do teste exato de Fisher, OR simples e coeficiente de correlação de Spearman. Todas assinaram o termo de consentimento livre e esclarecido previamente à entrevista, e o estudo foi aprovado no Comitê de Ética em Pesquisa da UNICAMP. Resultados: A média de idade das mulheres foi de 52,5 ± 10,9 anos e a média de tempo pós transplante foi de 5,8 ± 3,1 anos. Do total de 23 mulheres incluídas no estudo, 56,5% apresentaram massa óssea alterada. Estar na pós menopausa foi fator de risco para diminuição da massa óssea: OR 69,0 (95% IC 2,89-1647,18; p < 0,0001). Ter idade superior a 44 anos na realização do procedimento aumentou o risco para diminuição da massa óssea: OR 49,50 (95% IC 3,84-638,43; p <0,0001). Ter idade superior a 49 anos aumentou o risco para diminuição na massa óssea: OR 13,33 (95% IC 1,78-100,15; p = 0,0123). Apresentar um período de tempo maior que 5,8 anos da realização do transplante foi fator protetor para diminuição na massa óssea: OR 0,11 (95% IC 0,02-0,78; p = 0,0361). Conclusão: mais da metade das mulheres transplantadas hepáticas apresentaram diminuição da massa óssea. O estado menopausal, a idade, a idade ao transplante e o tempo pós transplante foram os fatores associados à alteração da massa óssea em mulheres transplantadas hepáticas
Abstract: Objectives: to evaluate bone mass and risk factors associated with bone mass alterations in women undergoing liver transplantation followed at the Liver Transplant Outpatient Unit in the Clinics Hospital of the Campinas State University Medical School. Subjects and Methods: a cross-sectional study of women undergoing liver transplantation and followed at the Liver Transplant Outpatient Unit in the Clinics Hospital of the Campinas State University Medical School was carried out. All women aged 35 years or older who had received a liver transplant at least one year before enrollment were included in the study. Thirty-three women satisfied the criteria for study inclusion. Of the total, 6 did not respond to telephone contact and 4 declined to participate. As a result, the final number of women participating in the study was 23. An interview was conducted always by the same investigator for collection of clinical and sociodemographic data, as well as the performance of a general physical and gynecological examination. After clinical evaluation, the women underwent laboratory tests (aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamma glutamyltransferase, total and fractionated bilirubin) and bone mineral density measurement of the lumbar spine and femur. Statistical analysis was performed by Fisher's exact test, simple OR and Spearman's rank correlation coefficient. All women signed a written informed consent term prior to the interview. The study was approved by the Research Ethics Committee of UNICAMP. Results: The mean age of the women was 52.5 ± 10.9 years and mean time since transplantation was 5.8 ± 3.1 years. Of the total number (23) of women included in the study, 56.5% had alteration in bone mass. Being postmenopausal was a risk factor for decreased bone mass: OR 69.0 (95% CI 2.89-1647.18; p < 0.0001). Being over 44 years of age at the time of the surgical procedure increased the risk for decreased bone mass: OR 49.50 (95% CI 3.84-638.43; p < 0.0001). Being over 49 years of age increased the risk for decreased bone mass: OR 13.33 (95% CI 1.78-100.15; p = 0.0123). A period of time longer than 5.8 years since transplantation was a protective factor for decreased bone mass: OR 0.11 (95% CI 0.02-0.78; p = 0.0361). Conclusion: more than 50% of the women undergoing liver transplantation had decreased bone mass. Menopausal status, current age, age at the time of transplantation and time since transplantation were factors associated with bone mass alterations in women receiving a liver transplant
Mestrado
Tocoginecologia
Mestre em Tocoginecologia
Carvalho, Euller Duarte de. "Associação entre o nível de atividade física, qualidade de vida e características das mulheres com 60 anos ou mais." [s.n.], 2010. http://repositorio.unicamp.br/jspui/handle/REPOSIP/313675.
Full textDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
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Resumo: Objetivo: Avaliar o nível de atividade física e a qualidade de vida em mulheres idosas e os fatores associados. Sujeitos e Métodos: Estudo de corte transversal através de entrevistas individuais com 271 mulheres com 60 anos ou mais que frequentavam o Serviço Social do Comércio de Campinas - SESC / Campinas e pacientes do Ambulatório de Menopausa do Centro de Atenção Integral à Saúde da Mulher - CAISM/UNICAMP. Os instrumentos utilizados foram o International Physical Activity Questionnaire (IPAQ - Versão 8) e o World Health Organization Quality of Life in Older Adults (WHOQOL - OLD). Os resultados do IPAQ foram avaliados através de tercis e a associação entre resultados do WHOQOL-OLD e IPAQ e características das mulheres pelos testes de T de Student/Mann-Whitney ou ANOVA/Kruskal - Wallis, e de análises múltiplas. Resultados: A média etária das mulheres foi de 67,4 + 5,3 anos. A análise de cada domínio da atividade física mostrou que 60,8% do tempo foram em atividades sentadas. Ser frequentadora do SESC, ter maior idade, sem companheiro, maior escolaridade e boa autopercepção do estado de saúde foram características que se associaram significativamente à prática de exercícios físicos moderados ou vigorosos. Evidenciou-se com a análise múltipla que frequentar o SESC aumentou 11,4 vezes as chances de praticar exercícios físicos moderados vigorosos, ter 70 anos ou mais aumentaram em 3,3 vezes as chances e escolaridade entre segundo grau completo ou mais em 2,4 vezes as chances de praticar exercícios físicos de intensidade moderada ou vigorosa. O escore médio de qualidade de vida foi de 66,9 + 11,7. O maior valor foi observado no domínio referente às habilidades sensoriais (72,0 + 18,8) e o menor à autonomia (60,3+ 16,2). Mulheres frequentadoras do SESC, com maior idade, sem companheiro, menor escolaridade, com boa autopercepção da saúde, que não usavam medicamentos, sem antecedentes de doenças e de estrato social mais elevado apresentaram melhor escore de qualidade de vida. Com a regressão linear observou-se que uma boa autopercepção da saúde aumentou o escore de qualidade de vida em 7,3 pontos, número maior de medicamentos diminuiu em 4,4 pontos e a pratica de exercícios físicos moderados ou vigorosos aumentou em 4,8 pontos o escore. Observou-se uma associação estatisticamente significativa entre a prática de exercício físico de intensidade moderado/vigorosa e melhores escores de qualidade de vida. Conclusões: Evidenciou-se a necessidade de esforços para a mudança do tipo e intensidade da atividade física em mulheres com 60 anos ou mais, com diminuição significativa do tempo gasto em atividades sentadas, com o objetivo de se atingir as recomendações para uma melhora nas condições físicas e manutenção da saúde. Da mesma maneira são necessários investimentos educacionais, bem como a criação de centros de convívio cultura e lazer, acessíveis a essa e outras populações para que possam compreender cada vez mais a importância da prática de atividades físicas para uma melhor qualidade de vida
Abstract: Objective: To evaluate the level of physical activity and quality of life in elderly women and factors associated. Subjects and Methods: A cross-sectional study was conducted using individual interviews with 271 women aged 60 years or older who belonged to the Trade Social Service (SESC), in Campinas, and patients attended in the Menopause Outpatient Clinic at the Women's Integrated Healthcare Center-CAISM/UNICAMP. The instruments used were the International Physical Activity Questionnaire (IPAQ - Version 8) and World Health Organization Quality of Life in Older Adults (WHOQOL - OLD). IPAQ results were evaluated by tertiles and the association between the WHOQOL-OLD and IPAQ results and subject characteristics was assessed by the Student's t test and Mann-Whitney test or ANOVA/Kruskal - Wallis, and multiple analyses. Results: The mean age of the women was 67.4 + 5.3 years. Analysis of each physical activity domain showed that 60.8% of the time was spent doing sitting activities. Belonging to SESC, being older, having no partner, having a higher school education and a good selfperception of health were characteristics significantly associated with the performance of moderate-intensity or vigorous-intensity physical activity. Multiple analysis indicated that belonging to SESC, being 70 years or older and having finished secondary education (or higher) increased the chance of engaging in moderate-intensity or vigorous-intensity physical activity by 11.4, 3.3 and 2.4 times, respectively. The mean quality of life score was 66.9 + 11.7. The highest value was observed in the domain related to sensory abilities (72.0 + 18.8) and the lowest score related to autonomy (60.3+ 16.2). Women belonging to SESC, those who were older, had no partner, had a lower school education, had a good selfperception of health, did not take medication, had no history of diseases and were from a higher social stratum had better quality of life scores. Using linear regression analysis, it was observed that a good self-perception of health increased the quality of life score by 7.3 points, the amount of medication taken decreased by 4.4 points and the performance of moderate or vigorous-intensity physical activity increased by 4.8 points. A statistically significant association was observed between the performance of moderate/vigorous intensity physical activity and better quality of life scores. Conclusions: It became evident that efforts are needed to change the type and intensity of physical activity in women aged 60 or older to significantly decrease time spent doing sitting activities, with the purpose of carrying out the recommendations for improving physical condition and maintaining health. In a similar manner, it is necessary to make an investment in education, as well as to establish cultural and leisure facilities, accessible to this population (and other populations) so that they may understand the increasing importance of performing physical activity to have a better quality of life
Mestrado
Ciencias Biomedicas
Mestre em Tocoginecologia
Santos, Valter Fausto dos 1959. "Estudo comparativo entre dois meios de distensão durante a histeroscopia diagnóstica em mulheres após a menopausa = Comparative study between two distension media during diagnostic hysteroscopy in postmenopausal women." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/309676.
Full textDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
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Resumo: Introdução: Atualmente, a histeroscopia é o procedimento padrão ouro para descrever a morfologia da cavidade uterina e a presença de lesões. Para a realização do procedimento é necessária a distensão da cavidade uterina. A distensão pode causar desconforto, dor e às vezes desistência do procedimento. Hoje em dia, duas técnicas de distensão têm sido utilizadas para a histeroscopia diagnóstica: com gás carbônico ou com coluna líquida (solução salina). Objetivos: Comparar a dor da paciente e a opinião do operador em relação à qualidade da imagem durante o procedimento, assim como a taxa de complicações do exame, relacionando-os com o tempo de duração do mesmo e características clínicas dessas mulheres, utilizando-se o gás carbônico (C02) ou solução salina como distensores da cavidade uterina. Sujeitos e método: Todas as mulheres após a menopausa que vieram encaminhadas da rede básica de saúde do município de Campinas ou região e dos ambulatórios de especialidades do CAISM/UNICAMP para realização de histeroscopia, no período de 07 de fevereiro de 2011 a 27 de fevereiro de 2012, foram convidadas a participar do estudo. Selecionou-se 140 pacientes que preencheram os critérios de inclusão e aceitaram participar do estudo. Foram então submetidas ao exame histeroscópico no ambulatório de Histeroscopia do DTG/CAISM/UNICAMP. A escolha da técnica para cada grupo foi feita por meio da randomização realizada através do programa SAS (distribuição de probabilidade uniforme) versão 9.2. A dor foi analisada pelo pesquisador, logo após a realização do exame, aplicando-se a escala visual analógica de dor (EVA). Os outros dados foram colhidos através de um questionário feito durante o exame e após o mesmo. Análise dos dados: Para a análise dos dados: dor, tempo de procedimento e qualidade da imagem, considerou-se um poder de 80% com um nível de significância de 5%. Foram utilizados teste t de Student, teste exato de Fisher, teste do qui quadrado e o teste não paramétrico de Mann Whitney, para comparação das médias de variáveis quantitativas. Resultados: Setenta e duas pacientes constituíram o grupo do CO2 e 68, o grupo da solução salina. A idade média, o tempo de menopausa e o índice de massa corporal (IMC) foram semelhantes nos dois grupos. O antecedente de cesárea foi maior no grupo do líquido (1,1±1,2) que no do gás (0,5±0,8) (p=0,0046). O escore médio de dor referido foi igual nos dois grupos, sendo (5,5±2,3 e 5,8±3,0), no grupo do CO2 e solução salina, respectivamente. O tempo total do exame foi maior no grupo da solução salina (3,5±1,57min) que com CO2 (2,6±1,55min) (p=0.0002). Quase a totalidade das pacientes aceitariam realizar o exame novamente (84,7% vs 89,7%, nos grupos de CO2 e líquido, respectivamente) (p=0.37). No grupo com líquido foi maior a taxa de falha por estenose de canal cervical (16,2%) que no grupo com gás (5,6%) (p=0.04). A qualidade da imagem foi considerada satisfatória em 100% e 96,3%, nos grupos com gás e líquido, respectivamente (p=0.37). Conclusões: A dor referida e a qualidade da imagem durante a histeroscopia diagnóstica foram iguais quando se utillizou CO2 ou líquido. A taxa de falha por estenose cervical, o antecedente de cesárea e o tempo total de procedimento foram maiores no grupo do líquido
Abstract: Presently hysteroscopy has been a "gold-standard" procedure to describe the morphology of the uterine cavity and the presence of lesions. The distension of the uterine cavity is necessary for the procedure and may cause discomfort, pain and sometimes its interruption. Two distension techniques have been utilized for the diagnostic hysteroscopy: one with carbon dioxide and another with liquid column (saline solution).Objectives: To compare the patient's pain and the surgeon's opinion in relation to the quality of the image during the procedure as well as the rate of complications of the test, relating them to their duration and clinical characteristics of the patients utilizing either carbon dioxide (CO2) or saline solution as distension media. Subjects and Method: All the post-menopausal women sent from health services of Campinas and neighboring cities and CAISM UNICAMP for the hysteroscopy procedure from February 7,2011 to February 27,2012 were invited to participate of the study. 140 patients who met the inclusion criteria were selected and underwent an office hysteroscopy at the DTG/CAISM/UNICAMP center. The technique was chosen by SAS program randomization distribution of uniform probability version 9.2 and reported to the patient afterwards. The pain was analyzed by the researcher soon after the procedure applying the visual analogue scale (VAS). The other data were collected by means of a questionnaire during and after the procedure. Data Analysis: For the analysis of pain, time of procedure and image quality an 80% power with 5% significance level was considered. The student't test, the exact Fisher's test, the square qui test and the Mann Witney test were utilized to compare the averages of the quantitative variables. Results: 72 and 68 patients comprised the CO2 saline solution groups, respectively. The average age, date of the last period and mass body index (MBI) were similar in both groups. The previous cesarean section was higher in the saline solution group (1.1±1.2) then in the CO2 group (0.5±0.8) ( p= 0.0046) . The pain average score was the same in both groups, i.e. (5.5±2.3) and (5.8±3.0) in the CO2 and saline solution groups, respectively. The total time of the procedure was longer in the saline solution group (3.5±1.57 minutes) than in the CO2 group (2.6±1.55 min) ( p= 0.0002). Almost all patients agreed on undergoing the procedure again ( 84.7% vs 89.7% in the CO2 and saline solution groups respectively)(p=0.37). The rate of failure by cervical stenosis was higher in the saline solution group (16.2%) than in the group CO2 group (5.6%)(p=0.04).The image quality was satisfactory (100% in the saline solution group and 96.3% in the CO2 group(p=0.37).Conclusions: Both pain and image quality during the diagnostic hysteroscopy were the same. The rate of failure by cervical stenosis, the cesarean section and the total time of the procedure were higher in the saline solution group
Mestrado
Fisiopatologia Ginecológica
Mestre em Tocoginecologia
Fernandes, Tatiane Rosa 1981. "Influencia do uso tópico do estrogênio ou testosterona ou acido poliacrilico sobre a funçao sexual em mulheres na pós menopausa = ensaio clinico controlado e aleatorizado = Eficcacy of vaginally applied estrogen, testosterone, polyacrylic acid on sexual function in postmenopausal women: a randomized controlled trail." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/313671.
Full textDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
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Resumo: Introdução: A atrofia vaginal é uma condição crônica frequente em mulheres na pós-menopausa que acarreta alterações em sua sexualidade e consequentemente em sua qualidade de vida. Recentes estudos avaliam novas alternativas de tratamento para essa ascendente queixa da população feminina. Entretanto, atualmente dispomos de poucas opções terapêuticas adequadamente avaliadas. Objetivo: Comparar a função sexual feminina após o uso tópico de estrogênio, testosterona e ácido poliacrílico com o uso de lubrificante vaginal. Métodos: Ensaio clinico randomizado com 80 mulheres na pós-menopausa, entre 40 e 70 anos, em seguimento no Ambulatório de Menopausa do CAISM Unicamp. As mulheres foram randomizadas para o tratamento tópico via vaginal com estrogênio, testosterona, ácido poliacrílico e lubrificante, três vezes na semana, por um período de 12 semanas, entre novembro de 2011 a janeiro 2013. Utilizou-se o Índice de Função Sexual Feminina para avaliar as mudanças da resposta sexual no início e após 6 e 12 semanas. Resultados: O ácido poliacrílico e a testosterona tópica, em comparação com o lubrificante após 12 semanas de tratamento, apresentaram aumento nos domínios: desejo sexual, lubrificação, satisfação, dor na relação sexual e escore total. O tratamento com o estrogênio tópico em comparação com o lubrificante apresentou melhora no domínio desejo. A análise intragrupo ao longo do tempo de tratamento evidenciou melhora nos domínios desejo, lubrificação, dor para as mulheres que utilizaram ácido poliacrílico, testosterona e estrogênio. Além disso, as mulheres que utilizaram testosterona apresentaram melhora ao longo do tempo nos domínios excitação, orgasmo e satisfação. Conclusão: O tratamento por 12 semanas- em mulheres na pós-menopausa com sintomas de atrofia vaginal - realizado com ácido poliacrílico, testosterona e estrogênio demonstrou melhora na função sexual feminina. quando comparado ao uso de lubrificante vaginal
Abstract: Introduction. Female libido is multifactorial and complex. Declining estrogen levels in postmenopausal women affects vaginal function. Aim. To evaluate female sexual function after using topical estrogen, testosterone or polyacrylic acid as vaginal lubricants with K-Y jelly as a placebo lubricant. Methods. This was a randomized controlled clinical trial on 80 postmenopausal women between 40 and 70 years of age with follow-up at the Menopause Clinic of the CAISM / Unicamp. The women were randomized to treatment with topical vaginal estrogen, testosterone, polyacrylic acid or oil lubricant alone, three times a week for a period of 12 weeks from November 2011 to January 2013. Main Outcome Measures. We used the Female Sexual Function Index (FSFI) to assess changes in sexual response at baseline, and after 6 and 12 weeks. Results. After 12 weeks of treatment, polyacrylic acid and topical testosterone produced improvements in the FSFI domains of sexual desire, lubrication, satisfaction, reduced pain during intercourse and total score compared with lubricant alone. Treatment with topical estrogen in comparison with lubricant alone showed an improvement in the FSFI field of desire. The intragroup analysis over the time of the treatment showed improvements in the fields of desire, lubrication, and reduced pain for polyacrylic acid, testosterone and estrogen. Furthermore, women who used testosterone showed improvements over time in the fields of arousal, orgasm and satisfaction. Conclusions. Treatment of postmenopausal women with symptoms of vaginal atrophy with polyacrylic acid, testosterone and estrogen for 12 weeks produced improvements in self-reported female sexual function when compared with a lubricant
Mestrado
Fisiopatologia Ginecológica
Mestra em Ciências da Saúde
Gomes, Débora Alessandra de Castro 1972. "Densidade mineral óssea e infecção pelo HIV em mulheres climatéricas = Bone mineral density and HIV infection in climateric women." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/312829.
Full textTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
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Resumo: Os avanços científicos com a utilização da terapia antiretroviral altamente potente (TARV), proporcionaram significativo aumento na expectativa de vida das mulheres HIV soropositivas. Por outro lado, elas estão vivenciando afecções próprias do envelhecimento, como a osteoporose de etiologia provavelmente multifatorial. Objetivo: Avaliar a densidade mineral óssea e fatores associados em mulheres climatéricas HIV soropositivas. Sujeitos e Métodos: Realizado estudo de corte transversal com 273 mulheres HIV soropositivas e 264 mulheres HIV soronegativas de 40 a 60 anos de idade, acompanhadas em atendimento ambulatorial especializado. Foram avaliadas características clínicas, laboratoriais e densidade mineral óssea. Análise estatística: Foram utilizados os testes de Yates, qui-quadrado de Pearson, Mann-Whitney e análises de regressão múltipla de Poisson e regressão linear. Resultados: A média etária das mulheres HIV soropositivas foi 47,7 anos e das soronegativas 49,8 anos. As mulheres HIV soropositivas apresentavam IMC menor que 25Kg/m² (51,6%) e 59,3% estavam na pré ou perimenopausa enquanto as HIV soronegativas 29,3% tinham IMC menor que 25 kg/m² e 42,1% estavam na pré ou peri menopausa. A prevalência de baixa massa óssea em L1-L4 foi de 33,5% no grupo soropositivo e 33,2 % no grupo soronegativo (p>0.999). No colo do fêmur foi de 33,1% no grupo HIV soropositivo e 27,6 % no grupo soronegativo (p=0,266). A análise de regressão linear múltipla mostrou associação inversa entre DMO da coluna lombar e estar na pós menopausa, ser HIV soropositiva, FSH > 40 mUI/ml e direta com IMC >25 Kg/m² . Em relação a DMO no colo do fêmur houve uma associação inversa com estar na pós menopausa, cor branca e associação direta com maior paridade e IMC >25 Kg/m². Dentre as mulheres HIV soropositivas o tempo médio da infecção era de 9.9 anos, 92% usavam TARV, tempo médio de TARV era de 9,4 anos, tempo decorrido desde o diagnóstico foi em média 9,9 anos. Os fatores associados à baixa massa óssea em L1-L4 foram maior idade (p<0,001), paridade > 2 (p=0,03), estar na pós menopausa (p<0,01) e FSH > 40 mUI/ml (p<0,001). No colo do fêmur a baixa massa óssea esteve associada à maior idade (p<0,001), não usar drogas ilícitas (p=0,03), estar na pós menopausa (p<0,01) e FSH >40 mUI/ml (p<0,001). Não houve associação de baixa massa óssea na coluna lombar (L1-L4) e colo do fêmur com variáveis associadas diretamente ao HIV. A análise de regressão múltipla de Poisson verificou associação entre baixa DMO em L1-L4 e colo do fêmur apenas com estar na pós menopausa. Conclusão: Não houve diferença significativa na DMO na coluna lombar L1-L4 e no colo do fêmur nas mulheres climatéricas HIV soropositivas e soronegativas. A prevalência de osteopenia/osteoporose em mulheres climatéricas HIV soropositivas recebendo TARV foi de 33,5% em L1-L4 e de 33,1% no colo do fêmur, enquanto nas soronegativas foram 33,2 % em L1-L4 e 27,6% no colo do fêmur. Os principais fatores associados à baixa DMO foram estar na pós menopausa e menor IMC em mulheres HIV soropositivas e negativas. Ser HIV soropositivo esteve associado a baixa DMO apenas em L1-L4
Abstract: Scientific advances in the use of highly active antiretroviral therapy (HAART), have provided a significant increase in the life expectancy of HIV positive women. Moreover, they themselves are experiencing disorders of aging, such as osteoporosis probably multifactorial etiology. Objective: To evaluate bone mineral density and associated factors in menopausal women HIV positive. Subjects and Methods: Conducted cross-sectional study of 273 HIV seropositive women and 264 HIV-seronegative women 40-60 years old, followed in a specialized outpatient care. Clinical and laboratory characteristics and bone mineral density were evaluated. Statistical analysis: tests Yates Mann-Whitney analysis of multiple Poisson regression and linear regression were used chi-square test, and. Results: The mean age of the HIV positive women was 47.7 years and 49.8 years for seronegative. HIV seropositive women had a BMI less than 25 kg / m² (51.6%) and 59.3% were pre- or perimenopausal HIV seronegative while 29.3% had a BMI less than 25 kg / m² and 42.1% were in pre- or peri-menopausal. The prevalence of low bone mass in L1-L4 was 33.5% in the HIV-positive group and 33.2% in the seronegative group (p> 0.999). Femoral neck was 33.1% in HIV-seropositive group and 27.6% in the seronegative group (p = 0.266). A stepwise multiple linear regression analysis showed an inverse association between lumbar spine BMD and being postmenopausal, be HIV seropositive, FSH> 40 mIU / ml and direct with BMI> 25 kg / m². In relation to BMD at the femoral neck there was an inverse association with being postmenopausal, white and direct association with higher parity, and BMI> 25 kg / m². Among the HIV-seropositive women the average time of infection was 9.9 years, 92% were using HAART, median time to ART was 9.4 years, time since diagnosis averaged 9.9 years. Factors associated with low bone mass in L1-L4 were older age (p <0.001), parity> 2 (p = 0.03), being postmenopausal (p <0.01) and FSH> 40 mIU / ml (p <0.001). Femoral neck low bone mass was associated with older age (p <0.001), not using illicit drugs (p = 0.03), being postmenopausal (p <0.01) and FSH> 40 mIU / ml (p <0.001). There was no association between low bone mass at the lumbar spine (L1-L4) and femoral neck variables associated directly with HIV. The analysis of multiple Poisson regression found an association between low BMD at L1-L4 and femoral neck only to be postmenopausal. Conclusion: There was no significant difference in BMD at the L1-L4 lumbar spine and femoral neck in women seropositive and seronegative climatic HIV. The prevalence of osteopenia / osteoporosis in menopausal women seropositive HIV receiving ART was 33.5% in L1-L4 and 33.1% at the femoral neck, while 33.2% were seronegative at L1-L4 and 27.6 % in the femoral neck. The main factor associated with low BMD were being menopausal and have lower BMI in HIV positive and negative women. HIV seropositive was associated with low BMD only in L1-L4
Doutorado
Fisiopatologia Ginecológica
Doutora em Ciências da Saúde
Rezende, Débora Aparecida Paccola de. "Prevalência de quedas referidas e fatores associados na transição e após menopausa." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/6/6136/tde-13032014-082136/.
Full textINTRODUCTION: Faced the gradual increase of falls from height with advancing age, it becomes essential to know the risk factors of the falls on women in transition and after menopause, in order to contribute with strategies for prevention and health promotion in their daily routine. OBJECTIVE: To estimate the prevalence of referred falls and characterize the association between falls and clinical and epidemiological variables of women of the Family Health Strategy of Pindamonhangaba City, SP. METHODS: In a study with observational design of the type cross-sectional linked to Health Project of Pindamonhangaba (PROSAPIN), it was used secondary randomized data from 875 women from 35 to 65 years old and they were investigated through a household survey and anthropometric measurements. The falls were included as a dependent variable and age, marital status, income, education, race, occupation, gynecologic history, chronic disease and those measured, medicines, obesity (body mass index), dietary habits, alcohol consumption, smoking, sleep, depression and physical activity. RESULTS: There were 749 women investigated with average age of 47.7 years (standard deviation 8.1); the prevalence of falls from height was 17.6 percent (95 percentCI: 14.9 - 20.5), the majority (54.2 percent) of the fallers were in the post menopausal. Of the women who fell, the prevalence of recurrence was 45.2 percent. The main causes were slipping (29.4 percent) and setbacks (19.8 percent). After multivariate analysis, it was found an association of falls with age (p=0.018), poor sleep quality (p=0.007) and comorbidities as hypertension (p=0.032) and depression (p=0.003). The comorbidities hypertension (p=0.055) and depression (p=0,001) associated too with recurrent falls, as well restricted the activities of daily living (p=0.000). CONCLUSION: The highest prevalence of falls occurred after the menopause and among the main factors associated its genesis emerged the age, hypertension, depression and bad sleep
Kumpula, Back Mirja, and Rondik Mohamad. "Barnmorskors uppfattningar om kvinnors behov i klimakteriet." Thesis, Högskolan i Skövde, Institutionen för hälsa och lärande, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-11264.
Full textTanna, Nuttan. "The role of a specialist menopause pharmacist." Thesis, King's College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393644.
Full textUtian, Wulf Hessel. "Menopause and its management the physiopathologic foundation." Doctoral thesis, Faculty of Health Sciences, 2021. http://hdl.handle.net/11427/32811.
Full textBAUMANN, BILLMANN VALERIE. "Traitement hormonal substitutif lors de la menopause." Université Louis Pasteur (Strasbourg) (1971-2008), 1989. http://www.theses.fr/1989STR15002.
Full textBaumann, Billmann Valérie. "Traitement hormonal substitutif lors de la menopause." Strasbourg 1, 1989. http://www.theses.fr/1989STR10896.
Full textTardivo, Ana Paula [UNESP]. "Investigação do consumo alimentar e dos indicadores da composição corporal das mulheres na pós-menopausa." Universidade Estadual Paulista (UNESP), 2008. http://hdl.handle.net/11449/93108.
Full textInvestigar o consumo alimentar e os indicadores da composição corporal de mulheres na pós-menopausa. Métodos: Trata-se de estudo clínico, transversal, com amostra de conveniência composta por 173 mulheres na pós-menopausa, seguidas no Ambulatório de Climatério e Menopausa do Hospital das Clínicas-Faculdade de Medicina de Botucatu – UNESP no período de junho de 2005 a junho de 2006. Foram incluídas no estudo mulheres com data da última menstruação há pelo menos 12 meses, usuárias e não usuárias de terapia hormonal (TH). Os hábitos alimentares foram avaliados por meio do recordatório de 24 horas e pelo Índice de Alimentação Saudável (IAS). Para avaliação antropométrica foram obtidos peso, estatura, índice de massa corpórea (IMC=peso/altura2), circunferência abdominal (CA), relação cintura-quadril (RCQ), gordura corporal (%GC) e massa magra (%MM). Foram mensurados colesterol total, HDL, LDL, triglicerídios e glicemia. Na análise estatística utilizou-se o teste t de Student e a Correlação de Pearson. Resultados: A média de idade foi de 54±7,6 anos. O sobrepeso e a obesidade estiveram presentes em 76% das participantes. De acordo com o IAS, 91% das mulheres apresentaram alimentação de má qualidade. O consumo de proteínas e carboidratos estava adequado, entretanto, a qualidade de lipídios ingerida foi inadequada, com gorduras saturadas acima de 7% e poliinsaturadas acima de 10%. Somente 9% das participantes tiveram consumo adequado de cálcio e 7% de ferro. Pela medida da RCQ, o risco para a doença cardiovascular foi considerado alto Resumo em 39% e muito alto 36% das mulheres. Cerca de 89% das mulheres apresentaram CA elevada (>80 cm) contribuindo para complicações metabólicas. Os valores médios de colesterol total, LDL e triglicerídios estavam acima do recomendável em 46%, 55% e 79% das mulheres, respectivamente, com HDL baixo em 55%.
To investigate the food consumption and indicators of body composition in post-menopausal women. Methods: This cross-sectional, clinical study was undertaken in a convenience sample consisting of 173 were at menopause and registered, as well as followed up, at the Menopause and Climacterium Outpatient Clinic of Botucatu Medical School Hospital- São Paulo State University/UNESP between June/2005 and June/2006. All women without menstruation for at least 12 months, users and non-users of hormone therapy (HT), were included in the study. The food consumption was assessed by the 24h-record food inquiry and the healthy eating index (HEI). The anthropometric indicators included: weight, height, body mass index (BMI= weight/height2), abdominal circumference (AC), waist/hip ratio (WHR), body fat (%BF) and lean mass (%LM). Data on total cholesterol, HDL, LDL, triglycerides and glycemia were also collected. The nonparametric t test of Student and Pearson’s correlation were used in the statistical analysis. Results: Mean age was 54 years ± 7.6. Overweight and obesity were observed in 76% of the patients. Based on the HEI values obtained, diet quality was poor in 91% of the cases. Protein and carbohydrate intakes were adequate, but the quality of the lipids consumed was inadequate in relation to saturated fat >7% and polyunsaturated fat > 10%. Calcium and iron intakes were adequate in only 9% and 7% of the cases, respectively. The risk of cardiovascular disease, as determined by the waist/hip ratio, was considered high in 39% and very high in 36% of the women. Abdominal circumference was Summary elevated (> 80 cm) in 89% of the patients, which contributed for the occurrence of metabolic complications.
Mendes, Paula de Holanda. "Fumar antecipa a menopausa ? Evidências do Estudo Pró-Saúde." Universidade do Estado do Rio de Janeiro, 2009. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=5211.
Full textThe definition of menopause is the moment when the ovarian function stops definitively. Once occurred, there is an increased risk of cardiovascular disease, Alzheimer disease, osteoporosis and bone fractures. When anticipated, menopause is related with higher risk of all-cause mortality and several serious illnesses. Because of the increasing population life expectancy, women may spend between one third to one half of their lives after menopause, and thats why postmenopausal health condition studies are important. There are many studies of factors that influence the age at menopause which have many different results and few of them are Brazilian ones. Smoking has been associated with earlier menopausal age. This studys aims are to analyses different aspects of the associations between smoking and the age of menopause, considering possible effects of smoking dose. The Pró-Saúde study data base was utilized with sectional analyses and a parametric proportional hazard survival regression model with a Weibull distribution. Our results point to a reduction of the menopause risk related to current smoking about 32% with active smokers achieving menopause 2,5 years latter than nonsmokers, adjusted to education and parity. However among current smokers, this study suggests a higher risk of 132% and 192% to those women who smoke about 10 to 20 cigarettes a day and those who smoke more than 20 pack-years, respectively, compared to those smokers of less than 10 cigarettes a day and less than 10 pack-years. Those groups achieved menopause 3.3 and 4.4 years earlier than controls, respectively. There was no evidence of association relating age at menopause with age at start smoking, time since stopped smoking or smoking duration. In this study, considering possible dose-response effects, smoking is shown as a factor related to anticipation of menopausal age in some aspects, although not in others.
Menna, Barreto Ana Lúcia V. "Sintomas vasomotores e associação entre adipocinas séricas (adiponectina e PAI-1), moléculas de adesão (ICAM-1 E VCAM-1) e estado nutricional de mulheres peri e pós-menopáusicas." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2013. http://hdl.handle.net/10183/88430.
Full textBackgroud: Climacteric is defined as the phase comprising the transition between reproductive and non-reproductive life of women. Besides vasomotor symptoms, mood swings and sleep at this time, women tend to gain more weight and modify the pattern of body fat distribution. It is known that adipokines released by adipose tissue, which have different actions as a function of immune, cardiovascular, metabolic and endocrine function may contribute to the development of comorbidities, such as atherosclerosis and type 2 diabetes mellitus. Other molecules are involved in metabolic processes such as cell adhesion molecules (CAM), which have been studied as predictors of cardiovascular events. It is known that in postmenopausal women, an inverse relationship between exercise practiced regularly and the main causes of comorbidities. Objectives: To analyze the association between climacteric vasomotor symptoms (VMS) and adiponectin, plasminogen activator inhibitor 1 (PAI-1), intercellular adhesion molecule 1(ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), lipid profile and nutritional status. Methods: This was a cross sectional study with 102 peri- and postmenopausal women from 40 and 65 years old that evaluated VMS, body mass index (BMI), waist circumference (WC), body fat percentage (BF%), adiponectin, PAI-1, ICAM-1 e VCAM-1, lipid profile, and glycemia. Results: Mean age 53.8 (± 5.4) years, median 48 (10.96) months from the last menstrual period. Overweight was observed in 41.2% of women, very high cardiovascular risk (WC ≥ 88 cm) in 50.0%, and BF% (mean ± standard deviation) was 33.3 ± 5.3%. Mean values were 22.5 (± 11.8) ng/dL for adiponectin, 284.9 (± 134.1) ng/dL for PAI-1, 457.0 (± 210.6) ng/dL for ICAM-1, 202.0 (± 61.3) ng/dL for VCAM-1, 214.4 (±42.3) mg/dL for total cholesterol, 51.0 (± 2.8) mg/dL for high-density level cholesterol (HDL-c), 138.8 (± 2.2) mg/dL for lowdensity level cholesterol (LDL-c), and 129.4 (± 67.8) mg/dL for triglycerides. 76 (74.5%) had hot flashes, 45 (44.1%) mild to moderate depression according Beck’s score, and 79 (77.5%) had insomnia according Pisttburg’s score (PSQI). 73 (71.6%) were classified as active according physical activity’s (IPAQ) score. No significant relationship was observed between adipokine or CAM levels and VMS. Adiponectin was negatively inversely associated with BMI. There was a statistically significant inverse correlation between age and hot flash intensity. Conclusions: VMS intensity was inversely related with age, and VMS were not associated with adiponectin, PAI- 1, ICAM-1 and VCAM-1. Changes in several study parameters, such as presence of overweight/obesity, increased WC and BF%, and hypercholesterolemia contribute to a higher risk for cardiovascular disease in this sample of peri and postmenopausal women, although we found no correlation between hot flashes and adipokines or adhesion molecules.
Borba, Clarissa Moreira. "Uso de sulpirida versus placebo na redução de fogachos durante o climatério : ensaio clínico randomizado." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2017. http://hdl.handle.net/10183/180980.
Full textObjective: To assess the effects of Sulpiride 50mg/day compared with placebo on vasomotor symptoms (frequency and intensity) and on quality of life of climacteric women. Methods: Climacteric women (N=28), aged between 47–62 years, with at least five episodes of vasomotor symptoms per day were recruited from a specialized outpatient clinic at a tertiary hospital in the south of Brazil and through a media call after inclusion and exclusion criteria were ensured. Placebo (n=14) and Sulpiride 50mg/day (n=14) were administrated during all trial period. The number and intensity records of hot flushes were evaluated for 1 week before and along 8 weeks after the intervention. The 36-item version Women’s Health Questionnaire (WHQ) was applied to assess the quality of life. Results: The frequencies and the intensities of hot flushes /day happened in a similar way in both groups, with an observed reduction of both parameters during the weekly follow up after the Sulpiride intervention (p=0.019 and p=0.009, respectively). Regarding women’s quality of life, Sulpiride 50mg/day reduced sleep problems scores after 8 weeks of treatment, when compared to placebo group (p=0.017. Conclusions: Our results suggest that the Sulpiride 50mg/day treatment showed significant trends on reducing climacteric vasomotor symptoms, justifying replication and further studies addressing the possible mechanisms by which Sulpiride could safely reduce hot flushes.