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1

Meier, Beat, Pasqualina Perrig-Chiello, and Walter Perrig. "Personality and Memory in Old Age." Aging, Neuropsychology, and Cognition 9, no. 2 (June 2002): 135–44. http://dx.doi.org/10.1076/anec.9.2.135.9544.

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2

Soininen, H. S., and P. J. Riekkinen. "ApoE and memory in old age." International Journal of Psychophysiology 25, no. 1 (January 1997): 63. http://dx.doi.org/10.1016/s0167-8760(97)85518-3.

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3

Schmiedek, Florian, Colin Bauer, Martin Lövdén, Annette Brose, and Ulman Lindenberger. "Cognitive Enrichment in Old Age." GeroPsych 23, no. 2 (June 2010): 59–67. http://dx.doi.org/10.1024/1662-9647/a000013.

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Lifestyles with high levels of cognitive activity have been linked to weaker declines in cognitive abilities with aging. Hence, computer-based cognitive training programs that facilitate intense, daily, cognitive practice may help older adults to maintain and improve their cognitive functioning. We present the rationale for and implementation of an internet-based training environment that includes tasks of perceptual speed, episodic memory, and working memory. It was implemented as platform-independent internet-based testing software and used in the COGITO study to investigate intraindividual variability and plasticity in 101 younger (age 20–31) and 103 older (age 65–80) adults across an average of 100 daily practice sessions. Observations from this study and retrospective self-report evaluations demonstrate the program’s feasibility and acceptance among participants.
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Cavallini, Elena, Adriano Pagnin, and Tomaso Vecchi. "The Rehabilitation of Memory in Old Age." Clinical Gerontologist 26, no. 1-2 (March 17, 2003): 125–41. http://dx.doi.org/10.1300/j018v26n01_11.

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5

Papenberg, Goran, Nina Becker, Beata Ferencz, Moshe Naveh-Benjamin, Erika J. Laukka, Lars Bäckman, and Yvonne Brehmer. "Dopamine Receptor Genes Modulate Associative Memory in Old Age." Journal of Cognitive Neuroscience 29, no. 2 (February 2017): 245–53. http://dx.doi.org/10.1162/jocn_a_01048.

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Previous research shows that associative memory declines more than item memory in aging. Although the underlying mechanisms of this selective impairment remain poorly understood, animal and human data suggest that dopaminergic modulation may be particularly relevant for associative binding. We investigated the influence of dopamine (DA) receptor genes on item and associative memory in a population-based sample of older adults (n = 525, aged 60 years), assessed with a face–scene item associative memory task. The effects of single-nucleotide polymorphisms of DA D1 (DRD1; rs4532), D2 (DRD2/ANKK1/Taq1A; rs1800497), and D3 (DRD3/Ser9Gly; rs6280) receptor genes were examined and combined into a single genetic score. Individuals carrying more beneficial alleles, presumably associated with higher DA receptor efficacy (DRD1 C allele; DRD2 A2 allele; DRD3 T allele), performed better on associative memory than persons with less beneficial genotypes. There were no effects of these genes on item memory or other cognitive measures, such as working memory, executive functioning, fluency, and perceptual speed, indicating a selective association between DA genes and associative memory. By contrast, genetic risk for Alzheimer disease (AD) was associated with worse item and associative memory, indicating adverse effects of APOE ε4 and a genetic risk score for AD (PICALM, BIN1, CLU) on episodic memory in general. Taken together, our results suggest that DA may be particularly important for associative memory, whereas AD-related genetic variations may influence overall episodic memory in older adults without dementia.
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Ghisletta, Paolo, John J. McArdle, and Ulman Lindenberger. "Longitudinal Cognition-Survival Relations in Old and Very Old Age." European Psychologist 11, no. 3 (January 2006): 204–23. http://dx.doi.org/10.1027/1016-9040.11.3.204.

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We use a statistical model that combines longitudinal and survival analyses to estimate the influence of level and change in cognition on age at death in old and very old individuals. Data are from the Berlin Aging Study, in which an initial sample of 516 elderly individuals with an age range of 70 to 103 years was assessed up to 11 times across a period of up to 13 years. Four cognitive ability domains were assessed by two variables each: perceptual speed (Digit Letter and Identical Pictures), episodic memory (Paired Associates and Memory for Text), fluency (Categories and Word Beginnings), and verbal knowledge (Vocabulary and Spot-a-Word). Longitudinal models on cognition controlled for dementia diagnosis and retest effects, while survival models on age at death controlled for age, sex, socioeconomic status, sensory and motor performance, and broad personality characteristics. Results indicate: (1) Individual differences in the level of and in the linear change in performance are present for all cognitive variables; (2) when analyzed independently of cognitive performance, all covariates, except broad personality factors, predict survival; (3) when cognitive performance is accounted for, age, sex, and motor performance do predict survival, while socioeconomic status and broad personality factors do not, and sensory performance does only at times; (4) when cognitive variables are analyzed independently of each other, both level and change in speed and fluency, as well as level in memory and knowledge predict survival; (5) when all cognitive variables are analyzed simultaneously using a two-stage procedure, none of them is significantly associated to survival. In agreement with others, our findings suggest that survival is related to cognitive development in old and very old age in a relatively global, rather than ability-specific, manner.
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Amer, Tarek, Jordana S. Wynn, and Lynn Hasher. "Cluttered memory representations shape cognition in old age." Trends in Cognitive Sciences 26, no. 3 (March 2022): 255–67. http://dx.doi.org/10.1016/j.tics.2021.12.002.

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8

Koike, Riki, Yuta Takaichi, Yoshiyuki Soeda, and Akihiko Takashima. "Memory formation in old age requires GSK-3β." Aging Brain 1 (2021): 100022. http://dx.doi.org/10.1016/j.nbas.2021.100022.

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9

Papenberg, Goran, Lars Bäckman, Irene E. Nagel, Wilfried Nietfeld, Julia Schröder, Lars Bertram, Hauke R. Heekeren, Ulman Lindenberger, and Shu-Chen Li. "COMT polymorphism and memory dedifferentiation in old age." Psychology and Aging 29, no. 2 (June 2014): 374–83. http://dx.doi.org/10.1037/a0033225.

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10

McCarthy, Michael. "Oestrogen helps to protect memory into old age." Lancet 351, no. 9095 (January 1998): 39. http://dx.doi.org/10.1016/s0140-6736(05)78087-9.

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11

Cockburn, J. M. "Behavioural assessment of memory in normal old age." European Psychiatry 11 (January 1996): 205s. http://dx.doi.org/10.1016/0924-9338(96)88591-9.

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12

Chowdhury, R., M. Guitart-Masip, N. Bunzeck, R. J. Dolan, and E. Duzel. "Dopamine Modulates Episodic Memory Persistence in Old Age." Journal of Neuroscience 32, no. 41 (October 10, 2012): 14193–204. http://dx.doi.org/10.1523/jneurosci.1278-12.2012.

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13

Arkowitz, Hal, and Scott O. Lilienfeld. "Memory in Old Age: Not a Lost Cause." Scientific American Mind 23, no. 5 (October 18, 2012): 72–73. http://dx.doi.org/10.1038/scientificamericanmind1112-72.

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14

Arkowitz, Hal, and Scott O. Lilienfeld. "Memory in Old Age: Not a Lost Cause." Scientific American 24, no. 1s (March 5, 2015): 34–35. http://dx.doi.org/10.1038/scientificamericansecrets0315-34.

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15

Nikolaeva, Elena, Elvira Dunaevskaya, Svetlana Burkova, Svetlana Nikiforova, and Vera Merenkova. "Age characteristics of the working memory." E3S Web of Conferences 258 (2021): 07016. http://dx.doi.org/10.1051/e3sconf/202125807016.

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This paper raises the question of the relationship between two mechanisms of working memory - Retrieval-Induced Forgetting (RIF) and Retrieval-Based Learning (RBL) in ontogenesis. Working memory is an element of executive functions, the effectiveness of which predetermines the success of learning, which determines the importance of studying the mechanisms of its implementation. RIF is a deterioration in the reproduction of subsequent stimuli as a result of reproduction of previous stimuli that are similar in some parameter. RBL is the reverse process, in which each subsequent reproduction in the working memory leads to better memorization of information when the memory is repeatedly tested. Comparison of works representing specific ages of the subjects does not allow us to imagine the complete change in the interaction of the two mechanisms with age. This is what became the task of this study. An original computerized technique was used (Razumnikova et al., 2016) which had been designed to memorize visual objects presented on a computer screen. The technique included three series, during which the same set of simple objects were presented, but the order of the presentation varied from series to series. The study involved 201 children: 17 children who were 3-4 years old, 90 children who were 5-7 years old, 47 children 10-11 who were years old and 47 children who were 12-14 years old. It is shown that RIF processes are mostly formed in children 3-4 years old. The effectiveness of RBL increases with age and reaches its greatest values by adolescence.
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Ruthig, Joelle C., Dmitri P. Poltavski, and Thomas Petros. "Examining Positivity Effect and Working Memory in Young-Old and Very Old Adults Using EEG-Derived Cognitive State Metrics." Research on Aging 41, no. 10 (August 13, 2019): 1014–35. http://dx.doi.org/10.1177/0164027519865310.

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The positivity effect among older adults is a tendency to process more positive and/or less negative emotional stimuli compared to younger adults, with unknown upper age boundaries. Cognitive and emotional working memory were assessed in young-old adults (60–75) and very old adults (VOAs; 80+) to determine whether emotional working memory declines similar to the age-related decline of cognitive working memory. The moderating role of valence on the link between age and emotional working memory was examined to identify change in positivity effect with advanced age. Electroencephalography (EEG) markers of cognitive workload and engagement were obtained to test the theory of cognitive resource allocation in older adults’ emotional stimuli processing. EEG recordings were collected during cognitive memory task and emotional working memory tasks that required rating emotional intensity of images pairs. Results indicate a positivity effect among VOAs that does not require additional cognitive effort and is not likely to diminish with age.
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17

Luszcz, Mary A. "Predictors of Memory in Young-old and Old-old Adults." International Journal of Behavioral Development 15, no. 1 (March 1992): 147–66. http://dx.doi.org/10.1177/016502549201500108.

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A contextualist approach was adopted to assess cognitive functioning and psychological well-being in a representative sample of young-old (60-74 years, n = 107) and old-old (75-92 years, n = 58) women and men in an effort to: (1) delineate age and gender similarities and differences within this elderly cohort; and (2) identify individual differences predictive of remembering. Measures of subjective well-being included morale, depression, and perceived control. Cognitive measures included intentional story recall and incidental symbol memory, rate of information processing, and cognitive flexibility. Health status, gender, and education were also investigated. Decrements were observed in intentional and incidental memory, rate of information processing, solution of Raven's Coloured Progressive Matrices, and Mini-Mental Status Examination, but not on accuracy of information processing, estimates of intelligence, well-being measures, education, or health status. The intentional story memory of women was more accurate than that of men. Education and gender, along with processing speed and mental ability, as indexed by the Raven coloured matrices, predicted story memory. These results of a representative sample validate recurrent trends seen in previous convenience samples. They extend the understanding of the relationship between ageing and cognition by identifying the role of processing resource, psychosocial, and demographic factors in modulating memory performance and highlighting methodological factors which must temper interpretation of these relationships.
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18

Di Nuovo, Santo, Rossana De Beni, Erika Borella, Hana Marková, Jan Laczó, and Martin Vyhnálek. "Cognitive Impairment in Old Age." European Psychologist 25, no. 3 (July 2020): 174–85. http://dx.doi.org/10.1027/1016-9040/a000391.

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Abstract. A decline in cognitive functioning is part of physiological aging. Accelerated cognitive decline is frequently linked to pathological changes, mostly due to Alzheimer’s Disease (AD), but is present also in Mild Cognitive Impairment (MCI) which is a predictor of transition to dementia. This review aims to summarize possible preventive biological and psychological treatments in different stages of lifespan to avoid more rapid cognitive decline and prevent pathological aging. Psychophysiological approaches aim to prevent brain damage and inflammation, two factors playing probably a major role in middle and old age. Interventions on working memory and imagery, using “cognitive reserve,” are beneficial for tolerating neuropathological age-related changes. Some controversial results are outlined, suggesting explanations for the inconsistency of findings. Although clear evidence from interventional studies is lacking, it seems that multi-domain interventions should be recommended to avoid or delay cognitive decline.
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19

Occhionero, Miranda, Lorenzo Tonetti, Marco Fabbri, Michele Boreggiani, Monica Martoni, Sara Giovagnoli, and Vincenzo Natale. "Prospective Memory, Sleep, and Age." Brain Sciences 10, no. 7 (July 3, 2020): 422. http://dx.doi.org/10.3390/brainsci10070422.

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It is reported that sleep enhances prospective memory (PM), but it remains to be understood whether this influence is moderated by age, since sleep changes across the lifespan. To this end, we performed a retrospective study in a naturalistic setting in a large life span sample: 397 healthy participants (227 females) from middle childhood (nine years old) to late adulthood (70 years old). Participants were requested to perform a naturalistic activity-based PM task, namely, to remember to press the event-marker button of an actigraph when they went to bed (activity 1) and when they got out of bed (activity 2) after nocturnal sleep. The percentages of button presses were the measure of our activity-based PM task. For activities 1 and 2, we separately performed a moderation model with actigraphic sleep parameters (sleep efficiency, midpoint of sleep, and total sleep time) as predictors of PM performance with age as a moderator factor. With reference to activity 1, we observed a significant interaction between sleep efficiency and age, showing a decrease in PM performance with the increase in sleep efficiency in the low age group. Only age was a significant (negative) predictor of PM in activity 2, i.e., with increasing age, PM performance significantly decreased. The present study shows, in a large life span sample, that sleep does not seem to play a relevant predictive role of activity-based PM performance.
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Sörman, Daniel Eriksson, Andreas Stenling, Anna Sundström, Michael Rönnlund, Mariana Vega-Mendoza, Patrik Hansson, and Jessica K. Ljungberg. "Occupational cognitive complexity and episodic memory in old age." Intelligence 89 (November 2021): 101598. http://dx.doi.org/10.1016/j.intell.2021.101598.

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21

Verhaeghen, Paul, Nathalie Geraerts, and Alfons Marcoen. "Memory Complaints, Coping, and Well-Being in Old Age." Gerontologist 40, no. 5 (October 1, 2000): 540–48. http://dx.doi.org/10.1093/geront/40.5.540.

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22

Connor, Lisa Tabor. "Memory in Old Age: Patterns of Decline and Preservation." Seminars in Speech and Language 22, no. 02 (2001): 119–28. http://dx.doi.org/10.1055/s-2001-13936.

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23

Levy, Becca. "Improving memory in old age through implicit self-stereotyping." Journal of Personality and Social Psychology 71, no. 6 (December 1996): 1092–107. http://dx.doi.org/10.1037/0022-3514.71.6.1092.

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24

Martschuk, Natalie, and Siegfried L. Sporer. "Memory for faces in old age: A meta-analysis." Psychology and Aging 33, no. 6 (September 2018): 904–23. http://dx.doi.org/10.1037/pag0000282.

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25

Jelicic, Marko, Cees Jonker, and Dorly J. H. Deeg. "Do health factors affect memory performance in old age?" International Journal of Geriatric Psychiatry 14, no. 7 (July 1999): 572–76. http://dx.doi.org/10.1002/(sici)1099-1166(199907)14:7<572::aid-gps994>3.0.co;2-7.

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26

Nagahama, Yasuhiro, Tomoko Okina, and Norio Suzuki. "Neuropsychological Differences Related to Age in Dementia with Lewy Bodies." Dementia and Geriatric Cognitive Disorders Extra 7, no. 2 (June 19, 2017): 188–94. http://dx.doi.org/10.1159/000477296.

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Background/Aims: To examine the influence of age on neuropsychological performances in dementia with Lewy bodies (DLB) and Alzheimer disease (AD) patients. Methods: We examined memory, executive, and visuo-constructional performances in 202 DLB patients and 236 AD patients. We divided the subjects into three age groups (65–74, 75–84, and 85–95 years old), and evaluated the differences in neuropsychological performances. Results: Recent memory in the DLB group was significantly better than that in the age-matched AD group when comparing the age groups 65–74 years and 75–84 years; however, memory impairment in the DLB patients in the age group 85–95 years was comparable with that in the age-matched AD patients. In contrast to recent memory, the other assessed neuropsychological performances, such as visuospatial and executive functions, showed no significant change in differences between the DLB and AD groups with advancing age. Conclusion: Our study revealed that the nature of memory impairment in DLB patients changes according to age. DLB patients in the young-old and old-old age groups showed significantly better memory performance than the age-matched AD patients, whereas memory performance of the DLB patients in the oldest-old age group was similar to that of the age-matched AD patients. This may be associated with the increased rate of coexisting AD pathology in DLB patients with older age.
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Lücke, Anna, Jelena Siebert, Oliver Schilling, Denis Gerstorf, Ute Kunzmann, Anna Kornadt, David Weiss, and Hans-Werner Wahl. "Examining the Relation Among Subjective Age and Working Memory in Old Age on a High-Frequency Basis Across 7 Days." Innovation in Aging 4, Supplement_1 (December 1, 2020): 598. http://dx.doi.org/10.1093/geroni/igaa057.2011.

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Abstract While increasing longitudinal evidence suggests that negative age views accelerate cognitive decline and increase dementia risk, we know little about such co-variance dynamics on a daily basis. We make use of subjective age and working memory performance data obtained six times a day over seven consecutive days as people went about their daily routines from 123 young-old (aged 66-69 years, 47.2% women) and 42 old-old (aged 86-90 years, 55.8% women) adults. Notably, multilevel models revealed considerably-sized short-term intra-individual variation of subjective age and working memory within days and these short-term within-day fluctuations in subjective age and working memory were coupled as expected. Hence, increased subjective age went along with lowered working memory confirming previous research. However, the respective between-day associations appeared reversed. Given this evidence of correlated short-term variability, we also discuss implications of different change dynamics that might explain moment-to-moment versus day-to-day associations between subjective age and working memory.
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Kraimi, N., G. De Palma, J. Lu, D. Bowdish, E. Verdu, E. Sibille, T. Prevot, S. M. Collins, and P. Bercik. "A14 THE INTESTINAL MICROBIOTA CONTRIBUTES TO AGE-RELATED MEMORY DECLINE." Journal of the Canadian Association of Gastroenterology 5, Supplement_1 (February 21, 2022): 17–18. http://dx.doi.org/10.1093/jcag/gwab049.013.

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Abstract Background Age-related deterioration of cognitive function and memory capacity occur in both humans and rodents. For example, significant memory deficits have been reported in conventionally raised (SPF) old mice compared to conventionally raised young mice submitted to a spatial memory task (Prevot et al., 2019, Mol Neuropsychiatry 5, 84–97). Microbiota-to-brain signaling is now well established in mice and humans, but the extent to which it influences age-associated memory decline is unknown. Aims Our study examines whether the intestinal microbiota contributes to age-associated changes in brain function. We address the specific hypothesis that age-associated cognitive decline is attenuated in the absence of the intestinal microbiota. Methods We assessed anxiety-like and depressive-like behavior, locomotor activity and spatial memory performance in young germ-free (GF) mice (2–3 months of age, n=24) and senescent GF mice (13–27 months old, n=22) maintained in axenic conditions, and compared them to conventionally raised (SPF) mice of the same age. Anxiety-like behavior, locomotor activity and depressive-like behavior were measured using the light-dark preference, open-field, and tail suspension tests. We also used the Y-maze test based on a spontaneous alternation task to assess cognition, with the alternation rate as a proxy of spatial working memory. The age-associated inflammation was assessed with IL-6 cytokine plasma concentrations measured by ELISA. Results Anxiety-like behavior and depressive-like behavior did not change with the age regardless of the microbial status. However, old SPF mice traveled less distance (866.8 cm) than young SPF mice (1375 cm, p &lt; 0.01) in the open-field. Similarly, old GF mice also traveled less distance (458.9 cm) than young GF mice (875.7 cm, p &lt; 0.0001). In contrast to old SPF mice, old GF mice did not show memory impairment in the spatial memory task. Indeed, old SPF mice displayed lower alternation rate of 58.3%, compared to that found in young SPF mice (76.9%, p &lt; 0.05) while both old and young GF mice had an identical alternation rate of 73.3% ( p &gt; 0.05). In addition, IL-6 plasma levels revealed that old GF mice did not show signs of age-associated inflammation that was evident in old SPF mice (3.68 vs. 13.93 pg/ml, p &lt; 0.05). Conclusions We conclude that the absence of age-related memory deficit in old germ-free mice is consistent with a role for the microbiota in age-related cognitive decline, likely mediated via the immune system, as suggested by the absence of age-associated inflammation in germ-free mice. We propose that novel microbiota-targeted therapeutic strategies may prevent or delay the cognitive decline of aging. Funding Agencies CIHRBalsam Family Foundation
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Decman, Vilma, Brian Laidlaw, Hildegund Ertl, and E. John Wherry. "Memory T cells generated in youth function well in old age (49.8)." Journal of Immunology 186, no. 1_Supplement (April 1, 2011): 49.8. http://dx.doi.org/10.4049/jimmunol.186.supp.49.8.

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Abstract Aging-associated changes negatively influence T cell responses. Since we previously observed that the memory CD8 T cells generated in aged mice have substantially reduced proliferative expansion upon secondary infection, we wanted to investigate if observed defects of memory T cells are due to the age of the cell or the age of the host when primed. Briefly, virus-specific memory T cells were generated by infecting young mice, aged mice or by infecting mice when they were young, but then allowing these mice to age for 2 years. T cells from these three groups were adoptively transferred to congenic young mice and these recipient mice were challenged to assess the recall capacity of memory T cells. We used both systemic (vaccinia virus or LCMV) and local (influenza virus) challenge models to investigate whether there were differences in the ability to respond to different types of infections and to assess the recall capacity of virus-specific T cells. Strikingly, the memory CD8 and CD4 T cells that were primed in young mice and then aged for 2 years responded as well as the memory T cells primed recently in young mice. These highly functional memory T cells appear largely impervious to age-associated changes occurring in their environment. As expected, memory CD8 and CD4 T cells recently generated in aged mice fail to mount strong recall responses. To conclude, our studies point to events during priming and the starting of T cell population in aged mice as a key area of focus.
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Giambra, Leonard M. "Frequency and Intensity of Daydreaming: Age Changes and Age Differences from Late Adolescent to the Old-Old." Imagination, Cognition and Personality 19, no. 3 (March 2000): 229–67. http://dx.doi.org/10.2190/xn4w-1cre-b0mh-84xt.

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Daydreaming likelihood and intensity were examined through responses to the Imaginal Processes Inventory. Giambra [1–8] and McCraven and Singer [9] have demonstrated adult age differences and seven-year changes. These earlier studies were expanded by increasing the size and diversity of the cross-sectional ( n = 2791, 17–95 yrs. old) and 5.45–9.54 year longitudinal samples ( n = 886) and by adding 11.45–16.67 year ( n = 628) and 17.40–23.44 year ( n = 290) longitudinal samples. Clear age differences and age changes occurred in daydream likelihood and intensity. Biological speed and efficiency of information-processing, current concern, attentional strategy, memory deficit, and age-related differences in response honesty explanations were evaluated.
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Egorova, Valentina Nikiforovna, Fevroniya Ivanovna Alekseeva, Natalia Vasilievna Matveeva, and Vasilisa Petrovna Fedorova. "PSYCHOLOGICAL AND PEDAGOGICAL MEMORY SUPPORT OF THE ELDERLY AGE PEOPLE." Globus: psychology and pedagogy 7, no. 3(43) (August 19, 2021): 14–21. http://dx.doi.org/10.52013/2713-3060-43-3-3.

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Markson, Elizabeth W. "Gender Roles and Memory Loss in Old Age: An Exploration of Linkages." International Journal of Aging and Human Development 22, no. 3 (April 1986): 205–14. http://dx.doi.org/10.2190/ee11-q8x0-1duw-d2xv.

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A framework relating gender roles, role loss, and memory is presented. For the now-old woman, her identity has usually been defined by her roles within the family; other personal touchstones have been less legitimate. In old age, when key family roles dwindle, many women who have relied on their families as sources of identity are placed in an anomic situation, especially women with limited resources. When few meaningful social roles exist in the present, memory becomes increasingly important as a link to develop and maintain the self. It is proposed that, without meaningful present roles to frame one's past experience, memory is likely to be characterized by a high frequency of nonintegrated, relatively meaningless relationships, in turn leading to a narrowing of horizons and inability to take the role of the other. Episodic memories may decay since present events have no interest and generic memory becomes impaired. A case study approach is used to examine the relationship between self-preoccupation, group affiliation, object relations, and memory loss among three older working-class women. Their speech patterns, specifically pronoun use, were analyzed and support the postulate that a high frequency of self-references indicates memory loss and paucity of present experience.
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33

Burke, Deborah M., and D. G. Mackay. "Memory, language, and ageing." Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences 352, no. 1363 (December 29, 1997): 1845–56. http://dx.doi.org/10.1098/rstb.1997.0170.

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This overview provides both theoretical and empirical reasons for emphasizing practice and familiar skills as a practical strategy for enhancing cognitive functioning in old age. Our review of empirical research on age–related changes in memory and language reveals a consistent pattern of spared and impaired abilities in normal old age. Relatively preserved in old age is memory performance involving highly practised skills and familiar information, including factual, semantic and autobiographical information. Relatively impaired in old age is memory performance that requires the formation of new connections, for example, recall of recent autobiographical experiences, new facts or the source of newly acquired facts. This pattern of impaired new learning versus preserved old learning cuts across distinctions between semantic memory, episodic memory, explicit memory and perhaps also implicit memory. However, familiar verbal information is not completely preserved when accessed on the output side rather than the input side: aspects of language production, namely word finding and spelling, exhibit significant age–related declines. This emerging pattern of preserved and impaired abilities presents a fundamental challenge for theories of cognitive ageing, which must explain why some aspects of language and memory are more vulnerable to effects of ageing than others. Information–universal theories, involving mechanisms such as general slowing that are independent of the type or structure of the information being processed, require additional mechanisms to account for this pattern of cognitive aging. Information–specific theories, where the type or structure of the postulated memory units can influence the effects of cognitive ageing, are able to account for this emerging pattern, but in some cases require further development to account for comprehensive cognitive changes such as general slowing.
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Ros-Cucurull, E., C. Cardona-Rubira, E. García-Raboso, R. F. Palma-Álvarez, L. Grau-López, C. Daigre, L. Rodríguez-Cintas, et al. "Cognitive impairment associated with drug use in old age people." European Psychiatry 41, S1 (April 2017): s876. http://dx.doi.org/10.1016/j.eurpsy.2017.01.1765.

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IntroductionSubstance use disorder is a growing phenomenon among old adults. It is usually significantly undervalued, misidentified, under diagnosed and poorly treated. It has been related to cognitive impairment but there are few studies focused on the elderly.AimTo evaluate the relationship between drug use and cognitive impairment in old adults.MethodsWe conducted a prospective study (basal and 6 month follow up) in 67 patients over 65 years old seeking for treatment for drug misuse (alcohol and prescription drugs, mainly benzodiacepines) in addiction and dual diagnosis unit in Barcelona. A specific protocol was performed to evaluate attention, executive function, working memory, learning capacity, fonetic and visual fluency, decision-making, visual construction and cognitive flexibility (FCT, CPT-II, N-BACK, COWAT FAS, TAP, SDMT, IGT, CVLT, TOL, RFFT, STROOP). Patients were compared with a control group (healthy non drug users) with same characteristics (gender, age range and education status). The protocol consisted in two separated sessions of 90 minutes each one performed by a neuropsychologist.ResultsResults obtained suggested that patients under drug misuse had worse scores in fluency, visual construction, memory and attention compared with controls. After 6 month treatment and achieving abstinence patients improve in cognitive skills as verbal learning, short-term memory and free recall of verbal information. Cognitive impairment profile changes depending on the substance abused (alcohol or benzodiacepines).ConclusionsDrug use can produce deleterious effects in old adults. However, those who achieve abstinence may improve some cognitive functioning as verbal learning, short-term memory and free recall of verbal information.Disclosure of interestThe authors have not supplied their declaration of competing interest.
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Angel, Lucie, Séverine Fay, Badiâa Bouazzaoui, and Michel Isingrini. "Two Hemispheres for Better Memory in Old Age: Role of Executive Functioning." Journal of Cognitive Neuroscience 23, no. 12 (December 2011): 3767–77. http://dx.doi.org/10.1162/jocn_a_00104.

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This experiment explored the functional significance of age-related hemispheric asymmetry reduction associated with episodic memory and the cognitive mechanisms that mediate this brain pattern. ERPs were recorded while young and older adults performed a word-stem cued-recall task. Results confirmed that the parietal old/new effect was of larger latency and reduced magnitude and less lateralized in the older group than the young group. Correlational and regression analyses indicated that the degree of laterality of brain activity determines the accuracy of memory performance and mediates age-related differences in memory performance among older participants. They also confirmed a cascade model in which the individual level of executive functioning of older adults mediates age-related differences in the degree of lateralization of brain activity, which in turn mediates age-related differences in memory performance.
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Rendell, Peter G., Alan D. Castel, and Fergus I. M. Craik. "Memory for Proper Names in Old Age: A Disproportionate Impairment?" Quarterly Journal of Experimental Psychology Section A 58, no. 1 (January 2005): 54–71. http://dx.doi.org/10.1080/02724980443000188.

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Livner, Åsa, Åke Wahlin, and Lars Bäckman. "Thyroid stimulating hormone and prospective memory functioning in old age." Psychoneuroendocrinology 34, no. 10 (November 2009): 1554–59. http://dx.doi.org/10.1016/j.psyneuen.2009.05.016.

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Lim, David, Leon Flicker, Arunasalam Dharamarajan, and Ralph N. Martins. "Can testosterone replacement decrease the memory problem of old age?" Medical Hypotheses 60, no. 6 (June 2003): 893–96. http://dx.doi.org/10.1016/s0306-9877(03)00072-0.

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39

Pansky, Ainat, Morris Goldsmith, Asher Koriat, and Shiri Pearlman-Avnion. "Memory accuracy in old age: Cognitive, metacognitive, and neurocognitive determinants." European Journal of Cognitive Psychology 21, no. 2-3 (March 2009): 303–29. http://dx.doi.org/10.1080/09541440802281183.

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40

Gilewski, Michael J., Elizabeth M. Zelinski, and K. Warner Schaie. "The Memory Functioning Questionnaire for assessment of memory complaints in adulthood and old age." Psychology and Aging 5, no. 4 (December 1990): 482–90. http://dx.doi.org/10.1037/0882-7974.5.4.482.

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MOSCOVITCH, MORRIS. "Memory from Infancy to Old Age: Implications for Theories of Normal and Pathological Memory." Annals of the New York Academy of Sciences 444, no. 1 Memory Dysfun (May 1985): 78–96. http://dx.doi.org/10.1111/j.1749-6632.1985.tb37581.x.

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Vecchi, Tomaso, Lorena Albertin, and Cesare Cornoldi. "Self-Assessment of Everyday Spatial Memory and Performance on Memory Tasks in Old Age." Clinical Gerontologist 20, no. 3 (September 21, 1999): 57–66. http://dx.doi.org/10.1300/j018v20n03_06.

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43

Kraimi, N., G. De Palma, J. Lu, D. Bowdish, E. Verdu, E. Sibille, T. Prevot, S. M. Collins, and P. Bercik. "A238 ABSENCE OF AGE-RELATED MEMORY DECLINE IN GERM-FREE MICE." Journal of the Canadian Association of Gastroenterology 4, Supplement_1 (March 1, 2021): 288–89. http://dx.doi.org/10.1093/jcag/gwab002.236.

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Abstract Background Age-associated deterioration of cognitive function and memory capacity occur in a variety of mammals, from humans to rodents. For example, significant memory deficits have been reported in conventionally raised (SPF) old mice compared to conventionally raised young mice submitted to a spatial memory task (Prevot et al., Mol Neuropsychiatry 2019). Microbiota to brain signaling is now well established in mice, but the extent to which this influences age-related memory decline is unknown. Aims Our project aims to determine whether the intestinal microbiota contributes to age-related changes in brain function. We address the hypothesis that age-related cognitive decline is attenuated in the absence of the intestinal microbiota. Methods We studied locomotor behavior and spatial memory performance in young germ-free (GF) mice (2–3 months of age, n=24) and senescent GF mice (13–27 months old, n=22) maintained in axenic conditions, and compared them to conventionally raised (SPF) mice. We used the Y-maze test based on a spontaneous alternations task to assess cognition, with alternation rate as a proxy of spatial working memory performance. The locomotor activity was measured using the open-field test. Results GF old mice traveled less distance (458.9 cm) than GF young mice (875.7 cm, p &lt; 0.001) but these differences in locomotor activity did not influence spatial memory performance. Indeed, both GF old and GF young mice had an identical alternation rate of 73.3% (p &gt; 0.05). This contrasted with the memory impairment found in old SPF mice that displayed lower alternation rate of 58.3%, compared to that found in young SPF mice (76.2%, p = 0.13). Conclusions We conclude that the absence of age-related memory decline in germ-free mice is consistent with a role for the microbiota in the cognitive decline associated with aging, likely through action on the immune system, well documented in SPF mice (Thevaranjan et al., Cell Host & Microbe 2017). We propose that novel microbiota-targeted therapeutic strategies may delay or prevent the cognitive decline of aging. Funding Agencies CIHRBalsam Family Foundation
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Tsai, Sheng-Feng, Nai-Wen Ku, Tzu-Feng Wang, Yan-Hsiang Yang, Yao-Hsiang Shih, Shih-Ying Wu, Chu-Wan Lee, Megan Yu, Ting-Ting Yang, and Yu-Min Kuo. "Long-Term Moderate Exercise Rescues Age-Related Decline in Hippocampal Neuronal Complexity and Memory." Gerontology 64, no. 6 (2018): 551–61. http://dx.doi.org/10.1159/000488589.

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Background: Aging impairs hippocampal neuroplasticity and hippocampus-related learning and memory. In contrast, exercise training is known to improve hippocampal neuronal function. However, whether exercise is capable of restoring memory function in old animals is less clear. Objective: Here, we investigated the effects of exercise on the hippocampal neuroplasticity and memory functions during aging. Methods: Young (3 months), middle-aged (9–12 months), and old (18 months) mice underwent moderate-intensity treadmill running training for 6 weeks, and their hippocampus-related learning and memory, and the plasticity of their CA1 neurons was evaluated. Results: The memory performance (Morris water maze and novel object recognition tests), and dendritic complexity (branch and length) and spine density of their hippocampal CA1 neurons decreased as their age increased. The induction and maintenance of high-frequency stimulation-induced long-term potentiation in the CA1 area and the expressions of neuroplasticity-related proteins were not affected by age. Treadmill running increased CA1 neuron long-term potentiation and dendritic complexity in all three age groups, and it restored the learning and memory ability in middle-aged and old mice. Furthermore, treadmill running upregulated the hippocampal expressions of brain-derived neurotrophic factor and monocarboxylate transporter-4 in middle-aged mice, glutamine synthetase in old mice, and full-length TrkB in middle-aged and old mice. Conclusion: The hippocampus-related memory function declines from middle age, but long-term moderate-intensity running effectively increased hippocampal neuroplasticity and memory in mice of different ages, even when the memory impairment had progressed to an advanced stage. Thus, long-term, moderate intensity exercise training might be a way of delaying and treating aging-related memory decline.
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Zinke, Katharina, Melanie Zeintl, Anne Eschen, Carole Herzog, and Matthias Kliegel. "Potentials and Limits of Plasticity Induced by Working Memory Training in Old-Old Age." Gerontology 58, no. 1 (2012): 79–87. http://dx.doi.org/10.1159/000324240.

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Fjell, Anders M., Kristine B. Walhovd, and Ivar Reinvang. "Age-Differences in Verbal Recognition Memory Revealed by ERP." Clinical EEG and Neuroscience 36, no. 3 (July 2005): 176–87. http://dx.doi.org/10.1177/155005940503600308.

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Seventy-four participants (aged 20–82 years) went through a continuous performance recognition memory task with multiple repetitions of words and non-words while ERPs were recorded from the scalp. The old/new ERP effect (the difference in activation to stimuli correctly recognized as old and stimuli correctly recognized as new) for words but not non-words declined with increasing age in a linear pattern, but the relationship between the old/new effect and age varied throughout the ERP time window. Differences in topography between age groups were manifested in a frontal shift in activation for older age groups. Further, the data point to differences in semantic versus non-semantic processing across the adult life span, and it is concluded that specific cognitive memory processes are differentially involved at different ages.
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Simpson, S., D. Beavis, J. Dyer, and S. Ball. "Should old age psychiatry develop memory clinics? A comparison with domiciliary work." Psychiatric Bulletin 28, no. 3 (March 2004): 78–82. http://dx.doi.org/10.1192/pb.28.3.78.

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Aims and MethodMemory clinics have become very popular in old age psychiatry and there is some pressure for them to be developed in old age services. However, there is little evidence to suggest that they are more advantageous over the traditional domiciliary visits or who should be seen in clinic. This was a naturalistic comparison of 76 consecutive new referrals to a memory clinic, with 74 consecutive new domiciliary requests within the same service over the same period of time. A retrospective case note review collected the clinical features and an 18-month prospective follow-up examined the subsequent clinical management.Clinical ImplicationsThe two groups were characterised more by their similarities than their differences. However, the domiciliary group had greater behavioural and psychological complications. The memory clinic patients were less likely to receive psychotropic medication and here more likely to be followed up.ResultsWe conclude that memory clinics might be less suitable for patients with prominent psychiatric complications. Memory clinics could complement the domiciliary model by providing early psychosocial/neuropsychiatric approaches, although this is likely to lead to an increased clinical case-load.
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Gangemi, Sebastiano, Giorgio Basile, Daniela Monti, Rosaria Alba Merendino, Giuseppe Di Pasquale, Ursula Bisignano, Vittorio Nicita-Mauro, and Claudio Franceschi. "Age-Related Modifications in Circulating IL-15 Levels in Humans." Mediators of Inflammation 2005, no. 4 (2005): 245–47. http://dx.doi.org/10.1155/mi.2005.245.

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Aging is associated to a progressive establishing of a chronic inflammatory state linked to a continuous long exposure to antigens. Since IL-15 stimulates the proliferation of memory T cells and the immunosenescence is characterized by accumulation of memory T cells and exhaustion of naive T cells, we analyzed IL-15 levels in sera from 30 ultralongeval subjects with respect to those from young and old adults. IL-15 levels were assayed by immunoenzymatic methods. Ultralongeval subjects displayed significantly higher IL-15 levels with respect to both young and old controls. No statistical difference was found between old and young controls. These findings may explain, at least in part, the characteristic increase of memory cells in immunosenescence and the capacity of the immune system of centenarians to defend itself from infections through immune-inflammatory responses.
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González-González, Estela, and Carmen Requena. "Practices of Self-Care in Healthy Old Age: A Field Study." Geriatrics 8, no. 3 (May 13, 2023): 54. http://dx.doi.org/10.3390/geriatrics8030054.

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Two competing psychological approaches for how to care for oneself to stay healthy in old age have coexisted and dominated the scientific literature. Objective: Identify the self-care practices of healthy older adults and establish the relationship between these practices and the cognitive processes involved. Method: 105 healthy older people (83.91% women) recorded their self-care practices using the Care Time Test and underwent a cognitive evaluation. Results: The frequency and variety of different activities that participants spent performing on a day of the week where they had the fewest obligations are as follows: nearly 7 h on seven survival activities, 4 h and 30 min on three maintenance of functional independence activities and 1 h on one activity that promoted personal development. Older people who carry out activities in a developmental approach showed better everyday memory (8.63 points) and attention levels (7.00 points) than older people who carry out activities using a conservative approach (memory: 7.43; attention level: 6.40). Conclusion: The results evidenced that the frequency and variety of activities that promote personal development are associated with better attention and memory performance.
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Dias, Bruna Fulgêncio, Letícia Oliveira Rezende, Leandro Fernandes Malloy-Diniz, and Jonas Jardim de Paula. "Relationship between visuospatial episodic memory, processing speed and executive function: are they stable over a lifespan?" Arquivos de Neuro-Psiquiatria 76, no. 2 (February 2018): 89–92. http://dx.doi.org/10.1590/0004-282x20170186.

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ABSTRACT The present study evaluated the association between episodic memory, executive function and processing speed in a sample with different age ranges. We tested the hypothesis that processing speed, executive function and memory are more strongly associated during childhood and old age. We evaluated 571 participants, aged six to 92 years, divided into four age groups: children/adolescents, young adults, middle-aged adults and older adults. Correlation analyses suggested that the shared variance between the processing speed and memory is strong in childhood but weak across other age ranges. Executive function, however, had a stronger association both in childhood and in old age, when compared with the intermediate stages. We conclude that the effects of processing speed and executive function on memory are not stable across human development. These functions may be compensatory mechanisms for memory functioning in childhood and old age.
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