Relevant bibliographies by topics / Membrane transport systems

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Membrane transport systems'

Author: Grafiati
Published: 4 June 2021
Last updated: 13 February 2022

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Journal articles on the topic "Membrane transport systems"

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Stephan, Wolfgang. "Complex membrane transport systems." Biophysical Chemistry 21, no. 1 (January 1985): 41–55. http://dx.doi.org/10.1016/0301-4622(85)85005-5.

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Briskin, Donald P. "Membranes and Transport Systems in Plants: An Overview." Weed Science 42, no. 2 (June 1994): 255–62. http://dx.doi.org/10.1017/s0043174500080371.

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Membranes define the outer boundary of the living protoplast and the internal compartmentation of plant cells. From a structural point of view, membranes consist of a lipid bilayer and proteins essential for functions such as solute transport, signal transduction, and numerous metabolic reactions. While membranes can represent a significant barrier to the free movement of many solutes, those with sufficient lipid solubility may move across membranes by dissolving into the lipid bilayer. However, selective membrane transport is generally observed for hydrophilic solutes such as mineral nutrients and cell metabolites. Such selective transport requires an input of metabolic energy, and in plants this occurs via the production of proton electrochemical gradients across the membrane by substrate- (ex. ATP, PPi) driven proton pumps. Selective solute transport is then mediated by membrane-associated secondary transport systems which utilize the proton electrochemical gradient to drive the transport process. This review of membrane structure and transport system function provides a background for a further examination of herbicide interactions with plant membranes.
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Hoffman, Joseph F. "Modulation of Membrane Transport Systems." Annual Review of Physiology 50, no. 1 (October 1988): 205. http://dx.doi.org/10.1146/annurev.ph.50.030188.001225.

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Garcia-Sa´inz, J. Adolfo. "Cell and membrane transport systems." Trends in Pharmacological Sciences 8, no. 9 (September 1987): 364. http://dx.doi.org/10.1016/0165-6147(87)90151-9.

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Marino, Angela, Silvia Dossena, Grazia Tamma, and Sandra Donnini. "Oxidative Stress and Membrane Transport Systems." Oxidative Medicine and Cellular Longevity 2018 (June 13, 2018): 1–2. http://dx.doi.org/10.1155/2018/9625213.

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Higa, Mitsuru. "Ionic Transport across Charged Membranes in Multi-component Ionic Systems." membrane 23, no. 6 (1998): 300–307. http://dx.doi.org/10.5360/membrane.23.300.

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Bastlein, C., and G. Burckhardt. "Sensitivity of rat renal luminal and contraluminal sulfate transport systems to DIDS." American Journal of Physiology-Renal Physiology 250, no. 2 (February 1, 1986): F226—F234. http://dx.doi.org/10.1152/ajprenal.1986.250.2.f226.

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4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS) was tested as an inhibitor of the sulfate transport systems in rat renal brush border and basolateral membrane vesicles. Na+-driven sulfate uptake into brush border membrane vesicles was half-maximally inhibited at 350 microM DIDS. Proton gradient-driven sulfate uptake into basolateral membrane vesicles was competitively inhibited by DIDS with a Ki of 2.4 microM. The Km for delta pH-driven sulfate uptake was 5.4 microM. The different affinities of the sulfate transport systems for DIDS correlated with different substrate specificities. The luminal transport system accepted a smaller range of anions than the contraluminal system and did not operate as a Na+-independent anion exchanger. After treatment of basolateral membrane vesicles with 50 microM DIDS at pH 8.4 for 30 min, an irreversible inhibition of sulfate uptake was observed. With brush border membranes, only a small irreversible inhibition was obtained. Lack of inhibition after treatment of basolateral membranes with DIDS at pH 6.4 indicated that DIDS reacted with deprotonated amino groups of the transport protein. Sulfate was protected from the irreversible inhibition by DIDS. Sodium-driven uptake of L-glutamate and methylsuccinate into basolateral membrane vesicles was not irreversibly inhibited by DIDS, indicating a specific action of DIDS on the contraluminal sulfate transport system. Irreversible and substrate-protectable inhibition of sulfate transport render DIDS suitable for future affinity labeling studies on the sulfate transport system in basolateral membranes.
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Nikonenko, Victor, Andrey Nebavsky, Semyon Mareev, Anna Kovalenko, Mahamet Urtenov, and Gerald Pourcelly. "Modelling of Ion Transport in Electromembrane Systems: Impacts of Membrane Bulk and Surface Heterogeneity." Applied Sciences 9, no. 1 (December 21, 2018): 25. http://dx.doi.org/10.3390/app9010025.

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Artificial charged membranes, similar to the biological membranes, are self-assembled nanostructured materials constructed from macromolecules. The mutual interactions of parts of macromolecules leads to phase separation and appearance of microheterogeneities within the membrane bulk. On the other hand, these interactions also cause spontaneous microheterogeneity on the membrane surface, to which macroheterogeneous structures can be added at the stage of membrane fabrication. Membrane bulk and surface heterogeneity affect essentially the properties and membrane performance in the applications in the field of separation (water desalination, salt concentration, food processing and other), energy production (fuel cells, reverse electrodialysis), chlorine-alkaline electrolysis, medicine and other. We review the models describing ion transport in ion-exchange membranes and electromembrane systems with an emphasis on the role of micro- and macroheterogeneities in and on the membranes. Irreversible thermodynamics approach, “solution-diffusion” and “pore-flow” models, the multiphase models built within the effective-medium approach are examined as the tools for describing ion transport in the membranes. 2D and 3D models involving or not convective transport in electrodialysis cells are presented and analysed. Some examples are given when specially designed surface heterogeneity on the membrane surface results in enhancement of ion transport in intensive current electrodialysis.
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Hoeltzli, S. D., and C. H. Smith. "Alanine transport systems in isolated basal plasma membrane of human placenta." American Journal of Physiology-Cell Physiology 256, no. 3 (March 1, 1989): C630—C637. http://dx.doi.org/10.1152/ajpcell.1989.256.3.c630.

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Concentrative transfer of amino acids from mother to fetus is affected by transport across both microvillous (maternal-facing) and basal (fetal-facing) plasma membranes of the human placental syncytiotrophoblast. Isolated basal plasma membrane vesicles were used to elucidate transport systems for neutral amino acids across this membrane. The concentration dependence and inhibition of zero-trans-alanine uptake were studied and four pathways for alanine uptake were defined as follows: 1) a sodium-dependent system shared by methylaminoisobutyric acid, which has the characteristics of an A system; 2) a sodium-dependent system resistant to inhibition by methylaminoisobutyric acid, which has the characteristics of an ASC system; 3) a sodium-independent system which may resemble an L system; 4) nonsaturable uptake. The microvillous membrane of the syncytiotrophoblast possesses systems similar to 1 and 3, but system 2 is unique to the basal plasma membrane. Active and passive transport of amino acids across both microvillous and basal plasma membranes may contribute to trophoblast amino acid uptake and nutrition and to the transfer of amino acids to the fetus.
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Malandro, M. S., M. J. Beveridge, M. S. Kilberg, and D. A. Novak. "Ontogeny of cationic amino acid transport systems in rat placenta." American Journal of Physiology-Cell Physiology 267, no. 3 (September 1, 1994): C804—C811. http://dx.doi.org/10.1152/ajpcell.1994.267.3.c804.

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Gestational regulation of the placental transfer of amino acids from maternal to fetal circulations is essential for the proper development of the fetus. The cationic amino acid transport systems of the microvillous (maternal facing) and basal (fetal facing) membranes of the rat placental syncytiotrophoblast were examined. Inhibition analysis documented the presence of three kinetically distinct cationic amino acid transport mechanisms: a single Na(+)-dependent mechanism in the microvillous membrane, which increased in activity from 14 to 20 days gestation but was absent from the basal membrane throughout the entire gestational period (system Bo,+), and two Na(+)-independent transport systems in both membrane domains, one that is completely inhibited by leucine, which increased in activity in both the microvillous and basal membrane domains, and the other that is leucine insensitive, which remained fairly constant in the basal membrane and increased throughout gestation in the microvillous membrane (system y1+). Northern analysis with the system y1+ cDNA revealed a specific band of approximately 7.4-7.9 kb, which increased with increasing gestational age.
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Dissertations / Theses on the topic "Membrane transport systems"

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Dart, Caroline. "Bicarbonate transport in mammalian cardiac muscle." Thesis, University of Oxford, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293393.

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Petrov, Eugene P., and Petra Schwille. "Diffusion and conformational dynamics in locally perturbed model membrane systems." Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-198919.

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In this article, we review our results on diffusion and phase separation in lipid membranes, as well as on interaction of membranes with colloidal particles, biomacromolecules, and supramolecular assemblies, which were obtained within the framework of the Saxon Research Unit FOR 877 “From Local Constraints to Macroscopic Transport”.
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Burgess, Sarah Elisabeth. "Membrane transport studies : novel methods, model systems and thermodynamics." Thesis, University of Greenwich, 2005. http://gala.gre.ac.uk/6121/.

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The work in this thesis shows that it is possible to design a diffusion cell which will allow access to the flux and lag time of a permeant without the need for invasive sampling and that this novel cell is both sensitive and reproducible. It was also shown that the cell could be used in conjunction with both simple model membranes and more complex biological membranes, namely the epidermis. From the data achieved from the cell it was possible to derive a series of equations which allowed access to thermodynamic parameters such as ?H, ?G and ?S. An extension of this calculational approach revealed that manipulation of the van’t Hoff isochore, under the condition where enthalpy is constant over the temperature range, it should be possible to calculate the partition coefficient. Ultimately these parameters can be used in the description of structure activity relationships. The systems described in this thesis are of a complex biological nature consequently the returned data reflect this complexity. In order to utilise the data to their full potential some method for dealing with this complexity was sought. One approach widely discussed in the literature is that of chemometric analysis or soft modelling. Initial studies into the use of chemometric analysis proved positive for the data presented in this thesis, and suggested that formulation contributions from components with close absorbance maxima could be separated.
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Petrov, Eugene P., and Petra Schwille. "Diffusion and conformational dynamics in locally perturbed model membrane systems." Diffusion fundamentals 23 (2015) 4, S. 1-17, 2015. https://ul.qucosa.de/id/qucosa%3A14583.

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In this article, we review our results on diffusion and phase separation in lipid membranes, as well as on interaction of membranes with colloidal particles, biomacromolecules, and supramolecular assemblies, which were obtained within the framework of the Saxon Research Unit FOR 877 “From Local Constraints to Macroscopic Transport”.
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Deyhim, Sina. "Deriving Gas Transport Properties of Microporous Silica Membranes from First Principles and Simulating Separation of Multi-Component Systems in Different Flow Configurations." Thesis, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/31340.

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Amorphous silica membranes have molecular sieving properties for the separation of hydrogen from gas mixtures at high temperature. Consequently, they are considered to be applied in separation of a shifted syngas coming out of a water-gas-shift-reactor into the syngas and hydrogen. This separation is a key to an Integrated Gasification Combined Cycle (IGCC) plant, which would allow reducing the carbon footprint in power generation industry. The main objective of this thesis was to carry out a preliminary assessment of suitability of currently available amorphous silica membranes for this separation. However, the separation properties of amorphous silica membranes reported in the open literature vary by orders of magnitude. Therefore, in the first part of this thesis the separation properties of hypothetical silica membrane with different pore size distributions were predicted from first principles. Considering different possible gas transport mechanisms, it was concluded that gas transport in amorphous silica membranes is dominated by the activated and non-activated Knudsen diffusion. The activation energy for transport of different species was predicted using the concept of suction energy. Then, with arbitrary pore size distributions gas permeance of hypothetical silica membrane was predicted for different gas species. Since the pore size distribution of amorphous silica membrane cannot be known a priori, the developed model was used to determine the pore size distribution based on experimentally measured single gas permeances of three different species (kindly provided by Natural Resources Canada, CANMET Energy Technology Center (CETC) laboratory in Ottawa) by minimizing the error of the calculated permeance ratios with respect to the experimental values. The results indicate that, depending on how the objective function is defined, more than one pore size distribution can be found to satisfy the experimental permeance ratios. It is speculated that by increasing the number of experimentally determined permeances, a more unique pore size distribution for the tested silica membrane can be obtained. However, even at this early stage, the developed model provides a rational explanation for the effect of membrane densification on the properties of silica membranes. More specifically, a simultaneous decrease in membrane permeance and selectivity due to membrane densification, reported in the literature, is explained by shrinking the size of pores beyond a certain critical value, which depends on the kinetic diameter of gas molecules that are being separated. Comparing theoretically determined permeances, which match experimentally observed permeance ratios, revealed that the experimental permeances are considerably smaller than the theoretical values. The ratio of the two provided the basis for a scaling factor, a new concept that was introduced in this thesis. To simulate membrane module performance, a novel approach was introduced. More specifically, co- and counter-current flow configurations as well as cross-flow configuration were modeled by assuming no change in feed composition over an infinitesimally small element of membrane area. This led to a system of linear, rather than differential equations, which was readily solved numerically.
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Mancini, Nicholas D. (Nicholas David). "Systems-level design of ion transport membrane oxy-combustion power plants." Thesis, Massachusetts Institute of Technology, 2011. http://hdl.handle.net/1721.1/67797.

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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2011.
Cataloged from PDF version of thesis.
Includes bibliographical references (p. 187-192).
Oxy-fuel combustion, particularly using an integrated oxygen ion transport membrane (ITM), is a thermodynamically attractive concept that seeks to mitigate the penalties associated with CO 2 capture from power plants. Oxygen separation in an ITM system consists of many distinct physical processes, ranging from complex electrochemical and thermochemical reactions to conventional heat and mass transfer. The dependence of ITM performance on power cycle operating conditions and system integration schemes must be captured in order to conduct meaningful process flow and optimization analyses. An axially spatially-distributed, quasi two-dimensional ITM model is developed based on fundamental conservation equations, semi-empirical oxygen transport equations obtained from the literature, and simplified fuel oxidation kinetic mechanisms. Aspects of reactor engineering such as geometric structure, flow configuration and the relationship between oxygen transport, fuel conversion and pressure drop are explored. Emphasis is placed on model robustness, modularity, and low computational expense. The model seeks to bridge the gap between detailed CFD studies and overly-simplified black-box models and provides a tool for the analysis and design of ITM systems. The ITM model is used to explore the dependence of ITM performance on reactor geometric structure, flow configuration, operating conditions, membrane material properties, and uncertainty in key modeling assumptions. Many operational constraints are presented that are usually overlooked by black-box modeling strategies, and the implications of these constraints are explored. Further, a comparison is made between reactive and separation-only ITMs to assess the relative merits and disadvantages of each. The results show that although a reactive ITM significantly improves the partial pressure driving force, practical reactor engineering considerations indicate that this concept is not superior to counter-current separation-only ITMs, mainly due to stringent temperature limitations of the membrane material. A Second Law assessment of certain ITM configurations is performed to evaluate the potential of ITM technology to reduce the air separation penalty and to guide effective systems-level integration. Finally, simulations of various ITM-based zero-emissions power cycles using the intermediate fidelity ITM model are performed. The first objective is to analyze the prevalent ITM-based power cycle designs and develop novel design modifications. The second objective is to investigate the effect of reactive ITM improvement design strategies proposed herein, such as the multiple compartment reactive ITM (MCRI), the low activation energy (LAE) materials reactive ITM, and hybrid reactive and separation-only concepts. An assessment of the potential for these novel ITM designs to reduce both the penalty and size associated with ITM air separation technology is conducted. The power cycle simulation and analysis clearly demonstrates the various challenges associated with implementing reactive ITMs. The hybrid cycle displays the potential to reduce the size of the ITM compared to the best separation-only concept while maintaining a comparable First Law efficiency. Additionally, the MCRI simulation results indicate comparable ITM size and pressure drops to the best separation only-concepts, greatly improving the attractiveness of reactive ITMs. Overall, the work herein finally allows for detailed optimization analyses to determine the best possible ITM oxy-combustion power cycles.
by Nicholas D. Mancini.
S.M.
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Ralli, Marianna. "Novel nucleoside transport systems in the inner membrane of Escherichia coli." Thesis, University of Edinburgh, 2006. http://hdl.handle.net/1842/15665.

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Nucleosides are transported across the inner membrane of E. coli by at least two separate energy-driven systems known as NupC and NupG. These systems are encoded by the genes nupC and nupG respectively. CTN1 (a mammalian transporter isolated form the jejunum) is a homologue of NupC. CNT1 is able to transport the nucleoside analogue AZT, used to combat HIV infection. CNT1 and NupC share substrate specificity and they have amino acid sequence identity of 27%, particularly in their C-terminal region. With the completion of the E. coli genome project paralogues of NupC and NupG have been found, designated as YeiM and YeiJ, and XapB and YegT respectively. To functionally characterise the putative nucleoside transporter-encoding genes xapB, yegT, yeiM and yeiJ, mutants were constructed which the coding sequence of these genes had been deleted from their chromosome. From this work it was established that all four putative nucleoside transporters XapB, YegT, YeiM and YeiJ were able to transport adenosine in the assays at similar levels as the positive control. Furthermore in kinetic analysis of the transporters it was possible to determine Km values for the four transporters with adenosine as substrate, which were in the same order of magnitude as mammalian nucleoside transporters and that shown for xanthosine uptake by XapB. The mutant strains were used to construct a bioassay, in which their ability to transport nucleoside analogues was assessed. AZT was used as model substrate. The use of multiple mutants in experiments involving nucleoside uptake as a sole carbon source further established the fact that the collection of genes studied in this project was indeed nucleoside permeases. Preliminary experiments gave an insight in developing a high throughput bioassay which can be developed further in order to produce a useful tool for nucleoside analogue drugs assessment.
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Stange, Christoph. "Combining artificial Membrane Systems and Cell Biology Studies: New Insights on Membrane Coats and post-Golgi Carrier Formation." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-102218.

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In mammalian cells, homeostasis and fate during development relies on the proper transport of membrane-bound cargoes to their designated cellular locations. The hetero-tetrameric adaptor protein complexes (APs) are required for sorting and concentration of cargo at donor membranes, a crucial step during targeted transport. AP2, which functions at the plasma membrane during clathrin-mediated endocytosis, is well characterized. In contrast, AP1 a clathrin adaptor mediating the delivery of lysosomal hydrolases via mannose 6-phosphate receptors (MPRs) and AP3 an adaptor ensuring the proper targeting of lysosomal membrane protein are difficult to study by classic cell biology tools. To gain new insights on these APs, our lab has previously designed an in vitro system. Reconstituted liposomes were modified with small peptides mimicking the cytosolic domains of bona fide cargoes for AP1 and AP3 respectively and thereby enabling the selective recruitment of these APs and the identification of the interacting protein network. In the study at hand we utilize above-described liposomes to generate supported lipid bilayers and Giant Unilamellar Vesicles (GUVs), large-scale membrane systems suited for analysis by fluorescence microscopy. By using cytosol containing fluorescently-tagged subunits, we visualized clathrin coats on artificial membranes under near physiological conditions for the first time. Moreover, we demonstrated clathrin-independent recruitment of AP3 coats on respective GUVs. Presence of active ARF1 was sufficient for the selective assembly of AP1-dependent clathrin coats and AP3 coats on GUVs. By using dye-conjugated ARF1, we show that ARF1 colocalized with AP3 coats on GUVs and that increased association of ARF1 with GUVs coincided with AP1-dependent clathrin coats. Our previous study identified members of the septin family together with AP3 coats on liposomes. Here we show on GUVs, that active ARF1 stimulated the assembly of septin7 filaments, which may constrain the size and mobility of AP3 coats on the surface. Subsequent cell biology studies in HeLa cells linked septins to actin fibers on which they may control mobility of AP3-coated endosomes and thus their maturation. An actin nucleation complex, based on CYFIP1 was identified together with AP1 on liposomes before. Here we show on GUVs, that CYFIP1 is recruited on the surface surrounding clathrin coats. Upon supply of ATP, sustained actin polymerization generated a thick shell of actin on the GUV surface. The force generated by actin assembly lead to formation of long tubular protrusions, which projected from the GUV surface and were decorated with clathrin coats. Thereby the GUV model illustrated a possible mechanism for tubular carriers formation. The importance of CYFIP1-reliant actin polymerization for the generation of MPR-positive tubules at the trans-Golgi network (TGN) of HeLa cells was subsequently demonstrated in our lab. The notion that tubulation of artificial membranes could be triggered by actin polymerization allowed us to perform a comparative mass spectrometry screen. By comparing the abundance of proteins on liposomes under conditions promoting or inhibiting actin polymerization, candidates possibly involved in stabilization, elongation or fission of membrane tubules could be identified. Among the proteins enriched under conditions promoting tubulation, we identified type I phosphatidylinositol-4-phosphate 5-kinases. Their presence suggested an involvement of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) in tubule formation. By cell biology studies in HeLa we show, that down regulation of these enzymes altered the dynamics of fluorescently-tagged MPRs, illustrating the importance of locally confined PI(4,5)P2 synthesis during formation of coated carriers at the TGN. Bin–Amphiphysin–Rvs (BAR) domains are known to sense membrane curvature and induce membrane tubulation. Among various BAR domain proteins, Arfaptin2 was enriched under conditions allowing tubulation of liposomes. By microscopy studies on HeLa cells we show, that Arfaptin2 as well as its close paralog Arfaptin1 were present on AP1-coated MPR tubules emerging from the TGN. We further show, that tubule fission occurred at regions were Arfaptin1 is concentrated and that simultaneous down regulation of both Arfaptins lead to increased number and length of MPR tubules. Since fission of coated transport intermediates at the TGN is poorly understood, our findings contribute a valuable component towards a model describing the entire biogenesis of coated post-Golgi carriers. In conclusion, combining artificial membrane systems and cell biology studies allowed us to propose new models for formation as wall as for fission of AP1-coated transport intermediates at the TGN. Further we gained new insights on AP3 coats and the possible involvement of septin filaments in AP3-dependent endosomal maturation.
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Bursell, James David Hingston. "Swelling-activated membrane transport systems in vertebrate and protozoan cells : a comparative study." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337564.

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Stokes, Neil Robert. "Analysis of the function and regulation of mechanosensitive channels in bacteria." Thesis, University of Aberdeen, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325233.

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Books on the topic "Membrane transport systems"

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Andreoli, Thomas E., Joseph F. Hoffman, Darrell D. Fanestil, and Stanley G. Schultz, eds. Membrane Transport Processes in Organized Systems. Boston, MA: Springer US, 1987. http://dx.doi.org/10.1007/978-1-4684-5404-8.

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Sharma, Kal Renganathan. Transport phenomena in biomedical engineering: Artificial organ design and development and tissue engineering. New York: McGraw-Hill, 2010.

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Sharma, Kal Renganathan. Transport phenomena in biomedical engineering: Artificial organ design and development, and tissue engineering. New York: McGraw-Hill, 2010.

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Mitochondrial medicine. New York: Humana Press, 2015.

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NATO Advanced Research Workshop on Molecular Biology of Mitochondrial Transport Systems (1992 Il Ciocco, Italy). Molecular biology of mitochondrial transport systems. Berlin: Springer-Verlag, 1994.

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Ito, Fumio. Comparative Aspects of Mechanoreceptor Systems. Berlin, Heidelberg: Springer Berlin Heidelberg, 1992.

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1935-, Morré D. James, ed. Cell-free analysis of membrane traffic: Proceedings of a Conference on Cell-Free Analysis of Membrane Traffic, held at the European Molecular Biology Laboratory, Heidelberg, Federal Republic of Germany, October 1-4, 1986. New York: Liss, 1988.

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1935-, Andreoli Thomas E., ed. Membrane transport processes in organized systems. New York: Plenum Medical Book Co., 1987.

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Developmental Biology of Membrane Transport Systems. Elsevier, 1991. http://dx.doi.org/10.1016/s0070-2161(08)x6037-x.

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Benos, Dale J. Developmental Biology of Membrane Transport Systems (Current Topics in Membranes). Academic Press, 1991.

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Book chapters on the topic "Membrane transport systems"

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Kobatake, Y., N. Kamo, and T. Shinbo. "Active Transport in Artificial Membrane Systems." In Membranes and Membrane Processes, 387–403. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4899-2019-5_40.

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Bonventre, J. V. "Cellular Calcium Transport Systems." In Membrane Transport in Biology, 262–316. Berlin, Heidelberg: Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-76983-2_6.

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Deves, Rosa. "Kinetics of Transport: Characterizing the Interaction of Substrates and Inhibitors with Carrier Systems." In Cell Membrane Transport, 3–19. Boston, MA: Springer US, 1991. http://dx.doi.org/10.1007/978-1-4757-9601-8_1.

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Cabantchik, Z. Ioav, and Ofer Eidelman. "Anion Transport Systems: Continuous Monitoring of Transport by Fluorescence (CMTF) in Cells and Vesicles." In Cell Membrane Transport, 341–67. Boston, MA: Springer US, 1991. http://dx.doi.org/10.1007/978-1-4757-9601-8_18.

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Sahai, Animesh, and Pallab K. Ganguly. "Transport Systems in Kidney Basolateral Membrane: Pathophysiologic Implications." In Membrane Physiopathology, 249–70. Boston, MA: Springer US, 1994. http://dx.doi.org/10.1007/978-1-4615-2616-2_15.

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Field, R. W. "Transport Processes in Membrane Systems." In Membranes in Bioprocessing: Theory and Applications, 55–112. Dordrecht: Springer Netherlands, 1993. http://dx.doi.org/10.1007/978-94-011-2156-9_3.

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Hagenbuch, Bruno, and Peter J. Meier. "Hepatocellular Transport Systems: Basolateral Membrane." In Molecular Pathogenesis of Cholestasis, 9–20. Boston, MA: Springer US, 2004. http://dx.doi.org/10.1007/978-1-4419-9034-1_2.

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Sélégny, Eric. "Tentative Classification of Transport-Reaction Systems by SeCDAR-Analysis (Uphill, Facilitated and Active Processes)." In Membranes and Membrane Processes, 55–67. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4899-2019-5_7.

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Yudilevich, David L., Luis A. Sobrevía, and L. Felipe Barros. "Characterization of Transport Systems for Solutes at the Blood Side of Endothelial and Parenchymal Cells by Single Circulation Paired-Tracer Dilution: A Review of Recent Studies." In Cell Membrane Transport, 87–106. Boston, MA: Springer US, 1991. http://dx.doi.org/10.1007/978-1-4757-9601-8_5.

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Dubinsky, William P. "The Study of Transport and Enzymatic Processes in Reconstituted Biological Systems." In Membrane Physiology, 167–73. Boston, MA: Springer US, 1987. http://dx.doi.org/10.1007/978-1-4613-1943-6_10.

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Conference papers on the topic "Membrane transport systems"

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Nagy, Endre. "Mass Transport Through Biocatalytic Membrane Reactors." In ASME 2008 9th Biennial Conference on Engineering Systems Design and Analysis. ASMEDC, 2008. http://dx.doi.org/10.1115/esda2008-59403.

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A mathematical model and its solution were developed to calculate the mass transport through catalytic membrane layer by means of explicit, closed expressions even in the case of the nonlinear Michaelis-Menten reaction kinetics and/or of variable mass transport — diffusion coefficient, convective velocity — parameters. Some typical examples on the Thiele modulus, applying the Michaelis-Menten kinetics and its limiting cases, namely the first-order kinetic (KM≫cm) and zero-order kinetic (cm≫KM) are shown for the prediction of the concentration distribution and the mass transfer rates as a function of the reaction modulus, namely first-order- and the zero-order reactions. It was shown the significant differences of the results obtained by the three different reaction orders.
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Enouf, J., R. Breadux, N. Bourdeau, and S. Levy-Toledano. "EVIDENCE FOR TWO DIFFERENT Ca2+TRANSPORT SYSTEMS ASSOCIATED WITH PLASMA AND INTRACELLULAR HUMAN PLATELET MEMBRANES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644490.

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The regulation of Ca2+ concentration in different cells involves two Ca2+ pumps. The presence of such mechanisms in human platelets is still controverted. We then investigated this question by using plasma and intracellular membranes obtained after simultaneous isolation by centrifugation ca 40% sucrose from a mixed 100,000 g membrane fraction.The Ca2+ uptake by the different membrane vesicles has been studied. Both membrane fractions took up Ca2+ and the Ca2+ transport systems exhibited a high affinity towards Ca 2+.However, the two associated Ca2+ transport systems showed a different time course and exhibited different oxalate sensitivity. The plasma membranes are not permeable to potassium oxalate, while the Ca2+ uptake was stimulated by potassium oxalate in intracellular membranes.Two Ca2+ activated ATPase activities are associated with the isolated membrane fractions and appeared different for the following parameters : 1) a different time course of the two enzyme activities; 2)a similar apparent affinity towards Ca2+ (10−7 M), though inhibition of the Ca2+ ATPase activity was only observed in intracellular membranes at 10−6 M Ca2+ ; 3)a different pH dependence with a maximum at pH 7 for the enzyme of intracellular membranes and pH 8 for the enzyme of plasma membranes; 4)a 10 fold difference in the ATP requirement of the enzymes, thus the maximal response was obtained with 20 uM for the intracellular membrane enzyme and with 200 uM for the plasma membrane enzyme ; 5) a different affinity for various nucleotides as energy donors with a higher specificity of the plasma membrane enzyme towards ATP ; 6) a different vanadate inhibition-dose reponse which did not exceed 60% for the plasma enzyme while it reached 100% for the intracellular enzyme.Taken together, these studies agree with the possible role of both a plasma membrane and a dense tubular system Ca2+ -ATPases in the regulation of Ca2+ concentration in human platelets.
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Cuppoletti, John. "Composite Synthetic Membranes Containing Native and Engineered Transport Proteins." In ASME 2008 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. ASMEDC, 2008. http://dx.doi.org/10.1115/smasis2008-449.

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Our membrane transport protein laboratory has worked with material scientists, computational chemists and electrical and mechanical engineers to design bioactuators and sensing devices. The group has demonstrated that it is possible to produce materials composed native and engineered biological transport proteins in a variety of synthetic porous and solid materials. Biological transport proteins found in nature include pumps, which use energy to produce gradients of solutes, ion channels, which dissipate ion gradients, and a variety of carriers which can either transport substances down gradients or couple the uphill movement of substances to the dissipation of gradients. More than one type of protein can be reconstituted into the membranes to allow coupling of processes such as forming concentration gradients with ion pumps and dissipating them with an ion channel. Similarly, ion pumps can provide ion gradients to allow the co-transport of another substance. These systems are relevant to bioactuation. An example of a bioactuator that has recently been developed in the laboratory was based on a sucrose-proton exchanger coupled to a proton pump driven by ATP. When coupled together, the net reaction across the synthetic membrane was ATP driven sucrose transport across a flexible membrane across a closed space. As sucrose was transported, net flow of water occurred, causing pressure and deformation of the membrane. Transporters are regulated in nature. These proteins are sensitive to voltage, pH, sensitivity to a large variety of ligands and they can be modified to gain or lose these responses. Examples of sensors include ligand gated ion channels reconstituted on solid and permeable supports. Such sensors have value as high throughput screening devices for drug screening. Other sensors that have been developed in the laboratory include sensors for membrane active bacterial products such as the anthrax pore protein. These materials can be self assembled or manufactured by simple techniques, allowing the components to be stored in a stable form for years before (self) assembly on demand. The components can be modified at the atomic level, and are composed of nanostructures. Ranges of sizes of structures using these components range from the microscopic to macroscopic scale. The transport proteins can be obtained from natural sources or can be produced by recombinant methods from the genomes of all kingdoms including archea, bacteria and eukaryotes. For example, the laboratory is currently studying an ion channel from a thermophile from deep sea vents which has a growth optimum of 90 degrees centigrade, and has membrane transport proteins with very high temperature stability. The transport proteins can also be genetically modified to produce new properties such as activation by different ligands or transport of new substances such as therapeutic agents. The structures of many of these proteins are known, allowing computational chemists to help understand and predict the transport processes and to guide the engineering of new properties for the transport proteins and the composite membranes. Supported by DARPA and USARMY MURI Award and AFOSR.
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Sadao Ota, Wei-Heong Tan, Hiroaki Suzuki, and Shoji Takeuchi. "Microfluidic formation of lipid bilayer array for membrane transport analysis." In 2008 IEEE 21st International Conference on Micro Electro Mechanical Systems. IEEE, 2008. http://dx.doi.org/10.1109/memsys.2008.4443582.

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Ruiz, Maria Noel, W. Andrew Jackson, and Audra Morse. "Transport Processes within a Hollow Fiber Membrane Reactor: Mass Transfer and Hydrodynamics." In International Conference On Environmental Systems. 400 Commonwealth Drive, Warrendale, PA, United States: SAE International, 2007. http://dx.doi.org/10.4271/2007-01-3093.

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Duncan, Andrew J., Donald J. Leo, Timothy E. Long, Barbar J. Akle, and Stephen A. Sarles. "Ionomer Design for Augmented Charge Transport in Novel Ionic Polymer Transducers." In ASME 2008 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. ASMEDC, 2008. http://dx.doi.org/10.1115/smasis2008-545.

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Ionic polymer transducers (IPT) are devices that display electromechanical transduction and have been applied extensively both as actuators and sensors. This study employs novel, highly-branched sulfonated polysulfones to investigate the contribution of polymer topology to electromechanical transduction. We assess two methods for ionic liquid uptake in the central ionomeric membrane. The effects of casting membranes in the presence of ionic liquid and swelling cast membranes in ionic liquid on film stability and ionic conductivity are examined. Casting in the presence of ionic liquid appears to cause macrophase separation of the ionic liquid from the polymer, causing limited charge transport. Overall, swelling appears to be a more stable method and achieves higher conductivity at lower uptake levels.
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Okada, Y., M. Tsugane, and H. Suzuki. "A microwell device for measurement of membrane transport of adherent cells." In 2015 28th IEEE International Conference on Micro Electro Mechanical Systems (MEMS). IEEE, 2015. http://dx.doi.org/10.1109/memsys.2015.7050984.

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Zhang, Hao, Vishnu Baba Sundaresan, Sergio Salinas, and Robert Northcutt. "Electrochemical Analysis of Alamethicin Reconstituted Planar Bilayer Lipid Membranes Supported on Polypyrrole Membranes." In ASME 2011 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. ASMEDC, 2011. http://dx.doi.org/10.1115/smasis2011-5038.

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Conducting polymers possess similarity in ion transport function to cell membranes and perform electro-chemo-mechanical energy conversion. In an in vitro setup, protein-reconstituted bilayer lipid membranes (bioderived membranes)perform similar energy conversion and behave like cell membranes. Inspired by the similarity in ionic function between a conducting polymer membrane and cell membrane, this article presents a thin-film laminated membrane in which alamethicin-reconstituted lipid bilayer membrane is supported on a polypyrrole membrane. Owing to the synthetic and bioderived nature of the components of the membrane, we refer to the laminated membrane as a hybrid bioderived membrane. In this article, we describe the fabrication steps and electrochemical characterization of the hybrid membrane. The fabrication steps include electropolymerization of pyrrole and vesicle fusion to result in a hybrid membrane; and the characterization involves electrical impedance spectroscopy, chronoamperometry and cyclic voltammetry. The resistance and capacitance of BLM have the magnitude of 4.6×109Ω-cm2 and 1.6×10−8 F/cm2.The conductance of alamethicin has the magnitude of 6.4×10−8 S/cm2. The change in ionic conductance of the bioderived membrane is due to the electrical field applied across alamethicin, a voltage-gated protein and produces a measurable change in the ionic concentration of the conducting polymer substrate.
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Hery, Travis M., and Vishnu-Baba Sundaresan. "Pore-Spanning PPy(DBS) as a Voltage-Gated Synthetic Membrane Ion Channel." In ASME 2016 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/smasis2016-9193.

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The transport of monovalent cations across a suspended PPy(DBS) polymer membrane in an aqueous solution as a function of its redox state is investigated. Maximum ion transport is found to occur when PPy(DBS) is in the reduced state, and minimum transport in the oxidized state. No deviation in the dynamics of ion transport based on the direction of the applied electrical field is observed. Additionally, it is found that ion transport rates linearly increased proportional to the state of reduction until a steady state is reached when the polymer is fully reduced. Therefore controlled, bidirectional ion transport is for the first time demonstrated. The effect of aqueous Li+ concentration on ion transport in the fully reduced state of the polymer is studied. It is found that ion transport concentration dependence follows Michaelis-Menten kinetics (which models protein reaction rates, such as those forming ion channels in a cell membrane) with an r2 value of 0.99. For the given PPy(DBS) polymer charge density and applied potential across the membrane, the maximum possible ion transport rate per channel is found to be 738 ions per second and the Michaelis constant, representing the concentration at which half the maximum ion transport rate occurs, is 619.5mM.
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Rosengarten, Gary. "Can We Learn From Nature to Design Membranes? The Intricate Pore Structure of the Diatom." In ASME 2009 7th International Conference on Nanochannels, Microchannels, and Minichannels. ASMEDC, 2009. http://dx.doi.org/10.1115/icnmm2009-82148.

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Membranes are ubiquitous functional elements used in separation processes. An ideal membrane will stop certain species penetrating it while having excellent transport properties for others. Membranes are used in synthetic systems such as fuel cells and desalination plants, but are also formed naturally in biological systems. For example all cells use a membrane to contain the cellular contents, while allowing transport of nutrients though the cell wall. I will present our recent work on examining diatoms, which are unicellular algae that grow in water. They have a self assembled silica membrane wall with a regular array of nanopores whose function is very poorly understood. I will outline the unique structure of the pores and our experimental work on understanding their structure to help develop membranes with better performance.
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Reports on the topic "Membrane transport systems"

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Goldsmith, M. H. M. Membrane vesicles: A simplified system for studying auxin transport. Office of Scientific and Technical Information (OSTI), January 1989. http://dx.doi.org/10.2172/6874189.

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Goldsmith, M. H. M. Membrane vesicles: A simplified system for studying auxin transport. Final technical report. Office of Scientific and Technical Information (OSTI), December 1989. http://dx.doi.org/10.2172/10124356.

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