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Journal articles on the topic 'Melanoma, Cancer, Tomato, Polyphenols'

Author: Grafiati

Published: 14 March 2023

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1

Pop, Teodora Daria, and Zorita Diaconeasa. "Recent Advances in Phenolic Metabolites and Skin Cancer." International Journal of Molecular Sciences 22, no. 18 (2021): 9707. http://dx.doi.org/10.3390/ijms22189707.

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Skin cancer represents any tumor development from the cutaneous structures within the epidermis, dermis or subcutaneous tissue, and is considered to be the most prevalent type of cancer. Compared to other types of cancer, skin cancer is proven to have a positive growth rate of prevalence and mortality. There are available various treatments, including chemotherapy, immunotherapy, radiotherapy and targeted therapy, but because of the multidrug resistance development, a low success has been registered. By this, the importance of studying naturally occurring compounds that are both safe and effec

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Isacescu, Ecaterina, Paul Chiroi, Oana Zanoaga, et al. "Melanoma Cellular Signaling Transduction Pathways Targeted by Polyphenols Action Mechanisms." Antioxidants 12, no. 2 (2023): 407. http://dx.doi.org/10.3390/antiox12020407.

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Melanoma is the most aggressive type of skin cancer. Although different anti-melanoma treatments are available, their efficacy is still improvable, and the number of deaths continues to increase worldwide. A promising source of antitumor agents could be presented by polyphenols—natural plant-based compounds. Over the past decades, many studies have described multiple anticancer effects of polyphenols in melanoma, presenting their potential interactions with targeted molecules from different signaling pathways. However, to our knowledge, there is no comprehensive review on polyphenols-regulated

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Martí, Raúl, Salvador Roselló, and Jaime Cebolla-Cornejo. "Tomato as a Source of Carotenoids and Polyphenols Targeted to Cancer Prevention." Cancers 8, no. 6 (2016): 58. http://dx.doi.org/10.3390/cancers8060058.

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Chen, Xianjin, Lili Chang, Yan Qu, Jinning Liang, Waishu Jin, and Xiujuan Xia. "Tea polyphenols inhibit the proliferation, migration, and invasion of melanoma cells through the down-regulation of TLR4." International Journal of Immunopathology and Pharmacology 31 (January 1, 2018): 039463201773953. http://dx.doi.org/10.1177/0394632017739531.

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Melanoma is the most common skin cancer and malignant melanoma which can cause skin cancer-related deaths. Toll-like receptor 4 (TLR4) had been reported to play an important role in melanoma, and tea polyphenol (TP) is regarded as an anticancer substance. However, the relationship between TP and TLR4 in melanoma is not well explored. Therefore, our aim is to figure out how TP has an influence on melanoma. Melanoma cell lines (B16F10 and A375) were treated with TP and lipopolysaccharides (LPS). Western blot assay was used to examine TLR4 expression, and MTT assay was conducted to assess prolife

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Helyes, Lajos, Zoltán Pék, Sára Brandt, and Andrea Lugasi. "Analysis of Antioxidant Compounds and Hydroxymethylfurfural in Processing Tomato Cultivars." HortTechnology 16, no. 4 (2006): 615–19. http://dx.doi.org/10.21273/horttech.16.4.0615.

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Tomato (Lycopersicon esculentum) fruit is an important source of antioxidants, which are important in the prevention of many cancer types and cardiovascular diseases. In ripe tomato fruit, one of the most significant antioxidant compounds is lycopene. In this study, effects of the cultivars and the environmental conditions on the lycopene content were investigated. Temperature effect was characterized by calculating growing degree-day (GDD). Relationships among lycopene, total polyphenols, organic acid, and total antioxidant status (TAS) were analyzed. A variation of more than 30% was found am

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Prakash, Monica D., Lily Stojanovska, Jack Feehan, et al. "Anti-cancer effects of polyphenol-rich sugarcane extract." PLOS ONE 16, no. 3 (2021): e0247492. http://dx.doi.org/10.1371/journal.pone.0247492.

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Plant polyphenols have an array of health benefits primarily thought to be related to their high content of anti-oxidants. These are commonly undervalued and knowledge of their biological properties have grown exponentially in the last decade. Polyphenol-rich sugarcane extract (PRSE), a natural extract from sugar cane, is marketed as high in anti-oxidants and polyphenols, but its anti-cancer activity has not been reported previously. We show that, PRSE exerts anti-cancer properties on a range of cancer cells including human (LIM2045) and mouse (MC38, CT26) colon cancer cells lines; human lung

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Fortes, C., S. Mastroeni, F. Melchi, et al. "FC4 Foods rich in polyphenols and N-3 fatty acids decrease cutaneous melanoma risk." Melanoma Research 20 (June 2010): e30. http://dx.doi.org/10.1097/01.cmr.0000382806.14581.52.

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Obrador, Elena, Rosario Salvador-Palmer, Ali Jihad-Jebbar, et al. "Pterostilbene in Cancer Therapy." Antioxidants 10, no. 3 (2021): 492. http://dx.doi.org/10.3390/antiox10030492.

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Natural polyphenols are organic chemicals which contain phenol units in their structures and possess antitumor properties. However, a key problem is their short half-life and low bioavailability under in vivo conditions. Pterostilbene (3,5-dimethoxy-4′-hydroxystilbene; PT) is a phytoalexin originally isolated from the heartwood of red sandalwood. As recently reported by our group, PT was shown to be effective in the treatment of melanoma. Counterintuitively, PT is not effective (cytotoxic) against melanoma in vitro, and only under in vivo conditions does PT display its anticancer activity. Thi

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Knez Marevci, Maša, Sašo Bjelić, Barbara Dariš, Željko Knez, and Maja Leitgeb. "The Influence of Extracts from Common Houseleek (Sempervivum tectorum) on the Metabolic Activity of Human Melanoma Cells WM-266-4." Processes 9, no. 9 (2021): 1549. http://dx.doi.org/10.3390/pr9091549.

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Human melanoma cells are known as one of the most aggressive cancer cells, and consequently, melanoma is one of the most incurable cancer diseases. There is intense activity in research and development of potential medicines for malignant diseases, including alternative forms of remedies. Therefore, the purpose of our work was testing extracts from the common houseleek (Sempervivum tectorum) grown in Slovenia to establish its impact on human melanoma cells. Namely, we wanted to verify if the extracts inhibit growth of malignant cells and their metabolic activity. Soxhlet, cold solvent, ultraso

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Szabo, Katalin, Laura Mitrea, Lavinia Florina Călinoiu, et al. "Natural Polyphenol Recovery from Apple-, Cereal-, and Tomato-Processing By-Products and Related Health-Promoting Properties." Molecules 27, no. 22 (2022): 7977. http://dx.doi.org/10.3390/molecules27227977.

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Polyphenols of plant origin are a broad family of secondary metabolites that range from basic phenolic acids to more complex compounds such as stilbenes, flavonoids, and tannins, all of which have several phenol units in their structure. Considerable health benefits, such as having prebiotic potential and cardio-protective and weight control effects, have been linked to diets based on polyphenol-enriched foods and plant-based products, indicating the potential role of these substances in the prevention or treatment of numerous pathologies. The most representative phenolic compounds in apple po

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Spissu, Ylenia, Katarzyna Angelika Gil, Antonio Dore, et al. "Anti- and Pro-Oxidant Activity of Polyphenols Extracts of Syrah and Chardonnay Grapevine Pomaces on Melanoma Cancer Cells." Antioxidants 12, no. 1 (2022): 80. http://dx.doi.org/10.3390/antiox12010080.

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The phenolic composition of Syrah and Chardonnay grape pomaces was studied to assess their antioxidant and prooxidant properties. Polyphenols were extracted by a "green" hydroalcoholic solvent (ethanol/water 1:1 v/v), and a detailed chemical and electrochemical characterization of the phenolic compounds was performed. The antioxidant and prooxidant capacity of the pomace was first studied by cyclic voltammetry (CV) and other reference analytical assays, then with biological tests on B16F10 metastatic melanoma cancer cells. Electrochemical data showed that, when a +0.5 V potential was applied,

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Gonzali, Silvia, and Pierdomenico Perata. "Anthocyanins from Purple Tomatoes as Novel Antioxidants to Promote Human Health." Antioxidants 9, no. 10 (2020): 1017. http://dx.doi.org/10.3390/antiox9101017.

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Anthocyanins are plant secondary metabolites belonging to the class of polyphenols, whose beneficial roles in the prevention and treatment of several important human diseases have been demonstrated in many epidemiological studies. Their intake through diet strictly depends on the eating habits, as anthocyanins are contained in red and purple fruit and vegetables as well as in some processed foods and beverages, such as red wine. Genetic engineering and breeding programs have been recently carried out to increase the content of anthocyanins in candidate plant species which cannot offer satisfac

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Luz, Jefferson Romáryo Duarte da, Jorge A. López, Macelia Pinheiro Ferreira, et al. "In Vitro Antithrombotic, Antitumor and Antiangiogenic Activities of Green Tea Polyphenols and Its Main Constituent Epigallocatechin-3-gallate." Processes 11, no. 1 (2022): 76. http://dx.doi.org/10.3390/pr11010076.

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The balance between embolic risk and bleeding represents a clinical challenge in cancer patient treatment, encouraging studies on adjuvant oncologic treatments. Thereby, this study evaluated the in vitro effect of green tea extract (GTE) and epigallocatechin-3-gallate (EGCG) on hemostasis modulation and the antineoplastic effect on melanoma cells (B16-F10) by applying platelet aggregation, angiogenesis and viability cell assays. The results displayed a significant platelet antiaggregant effect, corresponding to 50 and 80% for the extract and EGCG, respectively, compared to the negative control

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Prasad, Ram, and Santosh K. Katiyar. "Polyphenols from green tea inhibit the growth of melanoma cells through inhibition of class I histone deacetylases and induction of DNA damage." Genes & Cancer 6, no. 1-2 (2015): 49–61. http://dx.doi.org/10.18632/genesandcancer.52.

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Wu, W. B., H. S. Chiang, J. Y. Fang, and C. F. Hung. "Inhibitory effect of lycopene on PDGF-BB-induced signalling and migration in human dermal fibroblasts: a possible target for cancer." Biochemical Society Transactions 35, no. 5 (2007): 1377–78. http://dx.doi.org/10.1042/bst0351377.

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Tumours are complex tissues composed of both matrix proteins and stromal cells such as fibroblasts and inflammatory cells. Tumour progression is often the result of dynamic interactions between the tumour cells and their surroundings. Lycopene, a natural carotenoid that is abundant in tomato, has been shown to inhibit proliferation of several types of cancer cells through arrest of tumour cell-cycle progression, IGF-1 (insulin-like growth factor 1) signalling transduction, induction of apoptosis etc. However, in our recent study, we found that lycopene inhibited PDGF-BB (platelet-derived growt

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Urbonavičienė, Dalia, Česlovas Bobinas, Ramunė Bobinaitė, et al. "Composition and Antioxidant Activity, Supercritical Carbon Dioxide Extraction Extracts, and Residue after Extraction of Biologically Active Compounds from Freeze-Dried Tomato Matrix." Processes 9, no. 3 (2021): 467. http://dx.doi.org/10.3390/pr9030467.

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Supercritical carbon dioxide extraction (SCE-CO2) is an attractive, green technology that is used for the recovery of biologically active compounds from plant material. The antioxidant potential of lipophilic fractions (extract obtained with SCE-CO2) and hydrophilic fractions (extracts obtained from the residue after extraction) obtained from a matrix of freeze-dried tomatoes (cvs. “Admiro” F1, “Jurgiai”, “Vilina”, “Pirmutis”, and “Skariai”) was assessed via different antioxidant activity methods. The total amount of polyphenols, carotenoids, and carotenoid isomers before and after SCE-CO2 ext

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17

Vitalini, Sara, Marta Di Martile, Vittoria Cicaloni, et al. "Volatile and Non-Volatile Content Determination and Biological Activity Evaluation of Fresh Humulus lupulus L. (cv. Chinook) Leaves and Inflorescences." Separations 10, no. 2 (2023): 91. http://dx.doi.org/10.3390/separations10020091.

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In this work, the fresh leaves and inflorescences of Humulus lupulus L. cv. Chinook hops were investigated in order to describe their chemical composition and evaluate their biological activities. The analyses were carried out first on fresh untreated samples and then on pulverized ones using the SPME-GC-MS technique. In total, forty-two molecules belonging to different chemical classes were identified, and among these, twenty-three were terpene compounds. In order to carry out the activity assays, the powders were subjected to extraction with two different solvents (methanol and distilled wat

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Jabłońska-Trypuć, Agata, Urszula Wydro, Elżbieta Wołejko, Grzegorz Świderski, and Włodzimierz Lewandowski. "Biological Activity of New Cichoric Acid–Metal Complexes in Bacterial Strains, Yeast-Like Fungi, and Human Cell Cultures In Vitro." Nutrients 12, no. 1 (2020): 154. http://dx.doi.org/10.3390/nu12010154.

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Cichoric acid (CA) belongs to the group of polyphenols, which occurs in a variety of plant species and it is characterized by anticancer, antibacterial, and antiviral properties. Selected polyphenols have the ability to combine with metal ions to form chelate complexes that reveal greater biological activity than free compounds. In order to study possible antimicrobial and anticancer effect of CA and its complexes with copper(II)/zinc(II)/nickel(II)/cobalt(II) we decided to conduct cytotoxicity tests to estimate the most effective concentrations of tested compounds. The results of the presente

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19

Wang, Shihua, Valerie L. DeGroff, and Steven K. Clinton. "Tomato and Soy Polyphenols Reduce Insulin-Like Growth Factor-I–Stimulated Rat Prostate Cancer Cell Proliferation and Apoptotic Resistance In Vitro via Inhibition of Intracellular Signaling Pathways Involving Tyrosine Kinase." Journal of Nutrition 133, no. 7 (2003): 2367–76. http://dx.doi.org/10.1093/jn/133.7.2367.

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20

Danciu, Corina, Oana Cioanca, Claudia Watz Farcaș, et al. "Botanical Therapeutics (Part II): Antimicrobial and In Vitro Anticancer Activity against MCF7 Human Breast Cancer Cells of Chamomile, Parsley and Celery Alcoholic Extracts." Anti-Cancer Agents in Medicinal Chemistry 21, no. 2 (2020): 187–200. http://dx.doi.org/10.2174/1871520620666200807213734.

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Background: This study was designed as a continuation of a complex investigation about the phytochemical composition and biological activity of chamomile, parsley, and celery extracts against A375 human melanoma and dendritic cells. Objective: The main aim was the evaluation of the antimicrobial potential of selected extracts as well as the in vitro anticancer activity against MCF7 human breast cancer cells. Methods: In order to complete the picture regarding the phytochemical composition, molecular fingerprint was sketched out by the help of FTIR spectroscopy. The activity of two enzymes (ace

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21

Georgieva, Almira, Yana Ilieva, Zlatina Kokanova-Nedialkova, et al. "Redox-Modulating Capacity and Antineoplastic Activity of Wastewater Obtained from the Distillation of the Essential Oils of Four Bulgarian Oil-Bearing Roses." Antioxidants 10, no. 10 (2021): 1615. http://dx.doi.org/10.3390/antiox10101615.

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The wastewater from the distillation of rose oils is discharged directly into the soil because it has a limited potential for future applications. The aim of the present study was to determine in vitro the chromatographic profile, redox-modulating capacity, and antineoplastic activity of wastewater obtained by distillation of essential oils from the Bulgarian Rosa alba L., Rosa damascena Mill., Rosa gallica L., and Rosa centifolia L. We applied UHPLC-HRMS for chromatographic analysis of rose wastewaters, studied their metal-chelating and Fe(III)-reducing ability, and performed MTT assay for th

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Aguiar, Joselin, João L. Gonçalves, Vera L. Alves, and José S. Câmara. "Relationship between Volatile Composition and Bioactive Potential of Vegetables and Fruits of Regular Consumption—An Integrative Approach." Molecules 26, no. 12 (2021): 3653. http://dx.doi.org/10.3390/molecules26123653.

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In recent years, there has been a growing interest in studying and exploring the potential health benefits of foods, mainly from vegetables and fruits from regular intake. The presence of secondary metabolites, namely polyphenols, carotenoids and terpenes, in certain food matrices seems to contribute to their functional properties, expressed through an increased prevention in the development of certain chronic diseases, namely coronary heart diseases, neurodegenerative diseases, cancer and diabetes. However, some foods’ volatile secondary metabolites also present important bioactive properties

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Buda, Valentina, Ana-Maria Brezoiu, Daniela Berger, et al. "Biological Evaluation of Black Chokeberry Extract Free and Embedded in Two Mesoporous Silica-Type Matrices." Pharmaceutics 12, no. 9 (2020): 838. http://dx.doi.org/10.3390/pharmaceutics12090838.

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Black chokeberry fruits possess a wide range of biological activities, among which the most important that are frequently mentioned in the literature are their antioxidant, anti-inflammatory, anti-proliferative, and antimicrobial properties. The present paper reports, for the first time, the encapsulation of the ethanolic extract of Aronia melanocarpa L. fruits into two mesoporous silica-type matrices (i.e., pristine MCM-41 and MCM-41 silica decorated with zinc oxide nanoparticles). The aim of this work was to evaluate the antiradicalic capacity, the antimicrobial potential, and the effects on

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Sufianova, Galina, Ilgiz Gareev, Ozal Beylerli, et al. "Modern aspects of the use of natural polyphenols in tumor prevention and therapy." Frontiers in Cell and Developmental Biology 10 (September 12, 2022). http://dx.doi.org/10.3389/fcell.2022.1011435.

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Polyphenols are secondary plant metabolites or organic compounds synthesized by them. In other words, these are molecules that are found in plants. Due to the wide variety of polyphenols and the plants in which they are found, these compounds are divided according to the source of origin, the function of the polyphenols, and their chemical structure; where the main ones are flavonoids. All the beneficial properties of polyphenols have not yet been studied, since this group of substances is very extensive and diverse. However, most polyphenols are known to be powerful antioxidants and have anti

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Prieto, Karol, Yu Cao, Eslam Mohamed, et al. "Polyphenol-rich extract induces apoptosis with immunogenic markers in melanoma cells through the ER stress-associated kinase PERK." Cell Death Discovery 5, no. 1 (2019). http://dx.doi.org/10.1038/s41420-019-0214-2.

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Abstract Polyphenols elicit antitumor activities, in part, through the induction of anti- or pro-oxidant effects in cancer cells which promote priming of protective anti-tumor immunity. We recently characterized a polyphenol-rich extract from Caesalpinia spinosa (P2Et) that stimulates in vivo antitumor responses against breast and melanoma tumor models via the promotion of immunogenic cancer cell death (ICD). However, the primary mediators whereby P2Et promotes ICD remained unknown. Here, we sought to elucidate the role that severe endoplasmic reticulum (ER) stress plays in mediating P2Et-indu

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Das, Rina, Dinesh Kumar Mehta, and Meenakshi Dhanawat. "Medicinal Plants in Cancer Treatment: Contribution of Nuclear Factor-Kappa B (NF-kB) Inhibitors." Mini-Reviews in Medicinal Chemistry 22 (March 7, 2022). http://dx.doi.org/10.2174/1389557522666220307170126.

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Abstract: Nuclear factor-kappa B (NF-κB) is one of the principal inducible proteins that is a predominant transcription factor known to control the gene expression in mammals and plays a pivotal role in regulating cell signalling in the body under certain physiological and pathological conditions. In cancer cells, such as colon, breast, pancreatic, ovarian, melanoma, and lymphoma, the NF-κB pathway has been reported to be active. In cellular proliferation, promoting angiogenesis, invasion, metastasis of tumour cells and blocking apoptosis, the constitutive activity of NF-κB signalling has been

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Perużyńska, Magdalena, Anna Nowak, Radosław Birger, et al. "Anticancer properties of bacterial cellulose membrane containing ethanolic extract of Epilobium angustifolium L." Frontiers in Bioengineering and Biotechnology 11 (February 20, 2023). http://dx.doi.org/10.3389/fbioe.2023.1133345.

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Epilobium angustifolium L. is a medicinal plant well known for its anti-inflammatory, antibacterial, antioxidant, and anticancer properties related to its high polyphenols content. In the present study, we evaluated the antiproliferative properties of ethanolic extract of E. angustifolium (EAE) against normal human fibroblasts (HDF) and selected cancer cell lines, including melanoma (A375), breast (MCF7), colon (HT-29), lung (A549) and liver (HepG2). Next, bacterial cellulose (BC) membranes were applied as a matrix for the controlled delivery of the plant extract (BC-EAE) and characterized by

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Ferrari, Virginia, Gustavo Rodríguez, Matías González, et al. "Nutritional Quality and Nutraceutical Potential of Fruits and Vegetables as a tool for Genetic Breeding Programs." Agrociencia Uruguay 25, NE2 (2022). http://dx.doi.org/10.31285/agro.25.814.

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Prevention of the development of chronic diseases related to metabolic syndrome has been found to depend on a healthy diet. Among healthy foods, fruits and vegetables play a very important role due to their nutrient content, especially antioxidants, vitamins and polyphenols. For 20 years, INIA has promoted the concept of quality associated to the differentiation of products in the fruit and horticultural sectors, considering aspects not only linked to the organoleptic qualities, but also the production processes that ensure food safety and nutritional contribution. More recently, research work

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Cicero, Arrigo F. G., Olta Allkanjari, Gian Maria Busetto, et al. "Nutraceutical treatment and prevention of benign prostatic hyperplasia and prostate cancer." Archivio Italiano di Urologia e Andrologia 91, no. 3 (2019). http://dx.doi.org/10.4081/aiua.2019.3.139.

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During the last years, pharmaceutical innovations in primary care are dramatically less frequent and will be even more rare in the next future. In this context, preclinical and clinical research oriented their interest toward natural compounds efficacy and safety, supporting the development of a new “nutraceutical” science. Medicinal plants, in the form of plant parts or extracts of them, are commonly used for the treatment of prostate diseases such as benign hypertrophy, prostatitis and chronic pelvic pain syndrome. The pharmacological properties searched for the treatment of prostatic diseas

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WI, Abdel-Fattah, and El-Bassyouni GT. "Medicinal Functions of Physalis Fruits for Biomedical Applications." Austin Journal of Pharmacology and Therapeutics 9, no. 2 (2021). http://dx.doi.org/10.26420/austinjpharmacolther.2021.1135.

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Drug innovation using natural products is an interesting mission for planning new leads. It describes the bioactive compounds resulting from natural resources, characterization and pharmacological examination. It emphases on the triumph of these resources in the process of finding and realizing new and effective drug compounds that can be beneficial for human resources. For medicinal devotions and for the progress of pharmaceutical substances, medicinal plants were used such as Physalis angulata L which is a medicinal plant used for numerous therapies including wound healing (Figure 1) [1]. Fi

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