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Relevant bibliographies by topics / Melania G

Academic literature on the topic 'Melania G'

Author: Grafiati

Published: 10 December 2022

Last updated: 29 January 2023

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Journal articles on the topic "Melania G"

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Ardolino, Francesco. "Violence, Family and Gender: Melania G. Mazzucco’s crime novel." Quaderns d’Italià 22 (December 10, 2017): 181. http://dx.doi.org/10.5565/rev/qdi.26.

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Sais, Maria Luisa. "Per una nuova genealogia femminile: L’architettrice di Melania G. Mazzucco." Narrativa, no. 44 (November 30, 2022): 107–23. http://dx.doi.org/10.4000/narrativa.2408.

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Carton-Vincent, Alison. "Le sergent Manuela Paris dans Limbo de Melania G. Mazzucco (2012)." Italies, no. 19 (October 1, 2015): 329–40. http://dx.doi.org/10.4000/italies.5326.

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Ippolito, Antonella. "“L’orma nello schermo opaco”. Intermedialità del costrutto narrativo e rappresentazione di una “realtà depotenziata” in Un giorno perfetto (2005) di Melania G. Mazzucco." Linguæ & - Rivista di lingue e culture moderne, no. 15 (2016) 2 (December 2016): 49–67. http://dx.doi.org/10.7358/ling-2016-002-ippo.

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Morillas, Esther. "?Léxico, polifonía y traducción." Babel. Revue internationale de la traduction / International Journal of Translation 59, no. 4 (December 31, 2013): 393–405. http://dx.doi.org/10.1075/babel.59.4.01mor.

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In this article, we will reflect on the problems dealing with the translation of the lexis in contemporary literary texts. We will also study how lexis is the immediate reflection of the polyphony that prevails in the current narrative. In order to do this, first of all we will analyse the characteristics of the novels currently being published in Italy. Once we have established that lexical hybridization is one of the main ways of writing in many contemporary literatures (other than Italian), we shall go on to deal with the problems that arise during the translation of non-standard lexis.<p>Assuming that lexis is something that cannot be isolated from the rest of the text, and that other aspects, such as morphosyntax, must be always taken into account, we will study some examples from the translation into Spanish (by Xavier González Rovira) of Melania G. Mazzucco’s novel <i>Un giorno perfetto</i>, where the variety of the protagonists’ voices is clearly apparent. In order to maintain this polyphony, it will be necessary (apart from translating the mere meaning of a word or expression) to find equivalents for a specific register, as well as a style and some particular connotations that reflect the different ways of speaking found in Mazzucco’s work.<p>

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Ammanagi, Avinash Irappa, Shivasharana C.T., Krishnaveni R., Abhijeeth Shivappa Badiger, Vijaya Kumar Ramaraj, Srinath B. S., and Yalpi Karthik. "A biotechnological approach to optimization and production of melanin by Brevibacillus invocatus strain IBA, under submerged fermentation." Biomedicine 42, no. 2 (May 1, 2022): 318–24. http://dx.doi.org/10.51248/.v42i2.1315.

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Introduction and Aim: Melanin is a macromolecule with many biological activities, found across the animal, plant and microbes. This study focuses on parametric optimization of melanin production using a microbial. Materials and Methods: The soil samples were diluted to tenfold and spread plate technique was employed. The isolated cultures were subjected for melanin production the potential strain was selected and employed for mass production using nitrate broth supplement with L- tyrosine. The culture identification is by biochemical, microscopic and molecular sequencing and data retrieved through NCBI. Different physical parameters are used for the optimum growth of isolated culture. Results: The potential microbial culture was identified through 16s rRNA was Brevibacillus invocatus strain IBA with accession number 696201.1. This is an effective culture produced tyrosinase activity was 3282 U mg-1 and 0.554 g l-1 cell mass. The incubation duration highest melanin production was 48 hours, with 0.328 g l-1. Melanin production was better with 0.352 g l-1 at 120rpm agitation. In pH 6.5 remained establish to be optimum with 0.47 g l-1. Optimum temperature at 35°C high yield with 0.487 g l-1. Sucrose remained establish to be best carbon source with 0.512 g l-1 of melanin; while Tryptone as nitrogen sources produced the maximum melanin 0.548 g l-1. Thin layer chromatography was one of the useful methods to detect melanin from crude to pure melanin had an Rf value of 0.62. Conclusion: Chemical synthesis of melanin is expensive and involves multiple steps, animal or plant sources are cumbersome process. There are limitation and challenges to use the animal origin melanin for therapeutics and for food process. This investigation provides knowledge on factors affecting the melanin production using a bacterial culture in submerged fermentation technique.

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Kiberstis, P. A. "The dark side of melanin exposed." Science 347, no. 6224 (February 19, 2015): 836. http://dx.doi.org/10.1126/science.347.6224.836-g.

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Noman, Abeer Essam, Naif S. Al-Barha, and Fusheng Chen. "Characterization of Physicochemical Properties of Melanin Produced by Gluconobacter oxydans FBFS 97." Fermentation 8, no. 11 (October 23, 2022): 574. http://dx.doi.org/10.3390/fermentation8110574.

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The present study aimed to characterize melanin pigment extracted from Gluconobacter oxydans FBFS 97. After 14 days of culture at 28 °C in GY (glucose and yeast extract) liquid-state medium, G. oxydans FBFS97 produce the maximum melanin, up to about 12–15 mg/L. The physicochemical characteristics of the extracted melanin showed an ability to dissolve in 1 mol/L NaOH or 1 mol/L KOH, and insolubility in water and most organic solvents, such as chloroform and petroleum ether. The extracted melanin was confirmed to be exact melanin by ultraviolet-visible spectrophotometry, Fourier-transform infrared spectroscopy, thin-layer chromatography, elemental analysis, and scanning electron microscopy. The UV-visible spectrum of G. oxydans FBFS97 exhibited a maximum absorption peak at 230 nm. Extracted melanin demonstrated significant free radical-scavenging activity by DPPH and ABTS methods. The IC50 value of the extracted melanin for scavenging 50% DPPH radicals was 36.94 μg/mL, and the IC50 value of antioxidant activity for ABTS was 4.06 μg/mL. Hence, G. oxydans FBFS97 has the potential to be a new candidate for melanin production.

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Riyanto, Anwar, Taufiqurrachman Nasihun, and Titiek Sumarawati. "The Difference between the Effect of Green Tea Cream and Tocopherol on Decreasing Level of Tyrosinase Enzyme and Amount of Melanin in Rattus norvegicus Exposed to UVB Rays." Sains Medika 11, no. 1 (July 5, 2020): 20. http://dx.doi.org/10.30659/sainsmed.v11i1.4347.

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Introduction: Green tea and tocopherol are potent antioxidants used to treat melasma. However, whether green tea or tocopherol is superior remains unclear. Objective: To compare the effectiveness between green tea and tocopherol in decreasing the amount of melanin and tyrosinase level in wistar rats exposed to UVB rays.Methods: The experimental study took 30 male Wistar rats randomly and divided them into 3 groups. The control group (C-G) was given basic topical cream, GT-G was given green tea topical cream and TC-G was given tocopherol topical cream. All rats were exposed to UVB every Monday, Wednesday and Friday for 4 weeks, whereas topical creams were smeared every day. Topical creams smearing on the same day with UVB exposure was performed 20 minutes before exposure and 4 hours after UVB exposure. The doses of UVB were 50 mJ/cm2 in first week, 70mJ/cm2 in the second week and 80mJ/cm2 in the third and fourth weeks. The amount of melanin was measured using pixel method and the tyrosinase level was measured using ELISA.Results: Anova analysis indicates that the amount of melanin and tyrosinase level are significantly different between groups, p<0.05. Post Hoc LSD analysis indicates that the amount of melanin in GT-G and TC-G are significantly lower than that of C-G, p<0.05. The amount of melanin in GT-G is lower than that of TC-G, p<0.05. The tyrosinase level in GT-G is significantly lower than that of C-G and TC-G, p<0.05. Meanwhile, the tyrosinase level in TC-G is lower than that of C-G but insignificantly, p>0.05.� Conclusion: Green tea topical treatment is significantly capable of decreasing the amount of melanin and tyrosinase level better than tocopherol.

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Zhang, Fengpei, Fanzheng Xue, Hui Xu, Yuan Yuan, Xiaoping Wu, Junli Zhang, and Junsheng Fu. "Optimization of Solid-State Fermentation Extraction of Inonotus hispidus Fruiting Body Melanin." Foods 10, no. 12 (November 23, 2021): 2893. http://dx.doi.org/10.3390/foods10122893.

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Melanin has good nutritional and medicinal value; however, its extraction rate is extremely low. This study explored the edible and medicinal fungus Inonotus hispidus fruiting body melanin (IHFM) extraction process and solid-state fermentation conditions. The results showed that the best way to extract IHFM is the compound enzymatic method, with complex enzyme 26.63 mg/g, liquid material ratio 5:1, enzymatic hydrolysis 80 min, pH 4.61, and enzymolysis temperature at 36.07 °C. The yield of IHFM was 23.73 ± 0.57%, which was equivalent to 1.27 times before optimization. The best solid medium formula was normal pH, rice 20 g per cultivation bottle, maltose 22 g/L, beef extract 4.4 g/L, carbon-nitrogen ratio 5:1, and liquid-to-material ratio 1.1:1, where the IHFM yield was 31.80 ± 1.34%, which was equivalent to 1.7 times that before optimization. In summary, solid-state fermentation and extraction optimization greatly improved the yield of melanin, provided a reference to produce melanin, and laid a foundation for the development and utilization of melanin.

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Dissertations / Theses on the topic "Melania G"

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Keuper, Melanie [Verfasser], and Klaus G. [Akademischer Betreuer] Nickel. "Transformationskinetik der Niedertemperaturumwandlung von Zirkoniumdioxid / Melanie Keuper ; Betreuer: Klaus G. Nickel." Tübingen : Universitätsbibliothek Tübingen, 2015. http://d-nb.info/1197058257/34.

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Knospe, Melanie [Verfasser]. "Molekularbiologie und Pharmakologie neuer G-Protein-gekoppelter Purin-Rezeptoren / Melanie Knospe. Mathematisch-Naturwissenschaftliche Fakultät." Bonn : Universitäts- und Landesbibliothek Bonn, 2012. http://d-nb.info/1021605433/34.

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Stolzenberg, Melanie [Verfasser]. "Retrospektive Analyse der laparoskopisch assistierten suprazervikalen Hysterektomie (LASH) bei großen Uteri (≥ 500 g) / Melanie Stolzenberg." Greifswald : Universitätsbibliothek Greifswald, 2015. http://d-nb.info/1073591166/34.

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Neyra, Jennifer Eliana Montoya. "Modulação dos efeitos citotóxicos dos vemurafenibe pela cloroquina em células de melanoma maligno G-361: papel da dermicidina." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/42/42136/tde-30012018-101101/.

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Neste estudo foram avaliados os efeitos farmacológicos do vemurafenibe (inibidor BRAFV600E) e da cloroquina (inibidor de autofagia) na viabilidade celular e crescimento tumoral das sublinhagens de melanoma:G361 pLKO que expressa dermicidina e G361 IBC I com silenciamento da expressão. As células G-361 responderam a vemurafenibe (2 μM) e cloroquina (100 μM), isoladamente ou combinadas, com aumento apoptose, e redução das taxas de senescência. Vemurafenibe (50 mg/kg / 21 dias) inibiu o crescimento tumoral em camundongos imunodeficientes independente da expressão da DCD. A combinação com Cloroquina (30 mg/kg) a cada 24 horas, acelerou, enquanto a cada 72 horas, reduziu o crescimento tumoral. Os tumores apresentaram alterações morfológicas e núcleos atípicos; e não expressaram os marcadores S100, HMB-45, Mela-A ou citoqueratinas. Este trabalho confirmar a eficácia do vemurafenibe e sugere o potencial adjuvante da cloroquina no tratamento de melanomas. O estudo também confirma o papel da dermcidina como oncogne e fator de crescimento de células de melanoma maligno.
In this study we evaluated the pharmacological effects of vemurafenib ( inhibitor BRAFV600E) and chloroquine (autophagy inhibitor) in cell viability and tumor growth of two melanoma cell lines identified as G-361 pLKO, which expresses dermcidin, and G361 IBC I which silenced DCD expression. G-361 melanoma cells responded to vemurafenib (1-2 μM) and chloroquine (50-100 μM) alone or combined, with increased apoptosis rates, while decreasing senescent cells. Vemurafenib (50 mg/kg / 21 days) inhibited melanoma growth in immunodeficient mice independent of dermicidin. Chloroquine (30 mg/kg) in combination with vemurafenib, accelerated (at 24 hour interval), and reduced (at 72 hours interval), melanoma growth. Tumor tissues showed atypical cell morphology and nuclear histological patterns and melanocytic differentiation biomarkers S100, HMB-45, Melan-A or pancytokeratins were not. This work confirms the efficacy of vemurafenib and suggests potential adjuvant effect of chloroquine. It also confirms the role of dermcidin as growth factor and oncogene for melanoma cells.

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Castillo, Miguel Angel Zuñiga. "Expressão do antígeno leucocitário humano G, interleucina 10 e macrófagos M2 no melanoma lentiginoso acral." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/5/5133/tde-31072017-125708/.

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INTRODUÇÃO: O melanoma lentiginoso acral (MLA) é um subtipo pouco frequente do melanoma cutâneo que geralmente apresenta evolução desfavorável e agressiva. Os mecanismos patogenéticos relacionados a essa evolução clínica não são totalmente conhecidos. Atualmente, estudos da literatura enfocam os mecanismos de evasão imunológica relacionados ao microambiente do melanoma, uma vez que os mesmos podem inibir a resposta imune antitumoral permitindo a progressão da doença. A expressão do Antígeno Leucocitário Humano G (HLA-G) e da Interleucina 10 (IL-10) e os macrófagos M2 (MM2) do microambiente tumoral são estratégias de evasão imune desenvolvidas por algumas neoplasias. Esses fatores, entretanto, não têm sido estudados especificamente no MLA. OBJETIVOS: Com o propósito de verificar se a expressão tumoral do HLA-G, IL-10 e a população de MM2 no microambiente tumoral estão relacionados com as características histopatológicas preditivas de pior comportamento biológico do melanoma e o evento de metástase, fez-se a comparação desses marcadores e de MM2 entre grupos de MLA e de melanoma extensivo superficial (MES). MÉTODOS: A casuística estudada compreendeu 67 espécimes de MLAs e 67 de MESs. Os tumores foram classificados de acordo com sua espessura, ulceração, presença de mitoses e associação com metástases. Fez-se a demonstração da expressão do HLA-G, IL-10 e de MM2 (CD163+ e CD206+) por técnica de imuno-histoquímica. A expressão (fração de área tumoral imunomarcada) do HLA-G e IL-10, assim como o número de MM2 por unidade de área do microambiente intra e peritumoral foram comparados entre os grupos de tumores classificados como acima mencionado, utilizando-se os testes de Kruskal-Wallis e Wilcoxon. Verificou-se a correlação entre os marcadores HLA-G e IL-10 e entre CD163 e CD206 pelo teste de correlação de Pearson. Fez-se um modelo de regressão logística binária no qual foram incluídas incialmente todas as variáveis do estudo e sua interação com o evento presença de metástase. RESULTADOS: A expressão do HLA-G e IL-10 tumoral, assim como o número de MM2 da região intra e peritumoral dos espécimes de MLA foi maior que nos de MES (p < 0,05). Houve correlação positiva entre a expressão do HLA-G e IL-10, assim como entre o número de MM2 marcados por CD163 e CD206. No modelo de regressão logística binária, a variável número de macrófagos imunomarcados pelo anticorpo CD206 da região intratumoral mostrou-se significativa e relacionada com o evento metástase. CONCLUSÕES: As moléculas imunorreguladoras HLA-G e IL-10 expressas pelas células neoplásicas, assim como o número elevado de MM2 do microambiente tumoral devem ser considerados fatores envolvidos no comportamento biológico mais agressivo do MLA
BACKGROUND: Acral lentiginous melanoma (ALM) is an uncommon cutaneous tumor that usually has an aggressive behavior and results in an unfavorable prognosis. The pathogenic mechanism related to the clinical evolution remains unknown. Currently, evasion mechanisms related to the melanoma microenvironment, which can inhibit the anti-tumor immune response allowing disease progression, are the focus of numerous studies. The expression of human leukocyte antigen-G (HLA-G), Interleukin- 10 (IL-10) and M2-Macrophages (MM2) at the tumor site represents one of these immunosuppressive strategies developed for some neoplasms. However, those factors have not been studied specifically in ALM. OBJECTIVES: In order to verify if HLAG and IL-10 tumoral expression as well as MM2 population in the melanoma microenvironment are related to the histopathological features predictive of unfavorable prognosis in melanoma and metastasis, we compared those markers and cells between ALM and superficial spreading melanoma (SSM) groups. METHODS: We analyzed 67 ALM and 67 SSM cases. The tumors were classified in groups according thickness, ulceration, mitosis and metastasis. HLA-G, IL-10 and MM2 (CD163+ and CD206+) expression were evaluated using immunohistochemistry. The expression (tumoral positive area fraction) of HLA-G and IL-10, as well as the number of MM2 in the intratumoral and peritumoral area was compared between the groups of melanomas using Kruskal-Wallis and Wilcoxon\'s tests. The Pearson\'s test was used to establish the correlation between HLA-G and IL-10, as well as between CD163 and CD206. Also, a binary logistic regression model was used to analyze all variables in relation to metastasis. RESULTS: HLA-G and IL-10 tumoral expression as well as the number of MM2 in the intratumoral and peritumoral area was increased in ALM compared with SSM (p < 0.05). There was positive correlation between HLA-G and IL-10 tumoral expression, as well as between the number of MM2 marked by CD163 and CD206. In the binary logistic regression model, the MM2 CD206+ of the intratumoral area was significantly associated with metastasis. CONCLUSIONS: The HLA-G and IL-10 melanoma expression likewise the high number of MM2 in the tumoral microenvironment must be considered as features associated with the increased aggressiveness of the ALM

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Oliveira, Cristiane de 1985. "Influência dos polimorfismos P53 ARG72PRO, MDM2 T309G, BCL2 C(-938)A e BAX G(-248)A, relacionados com apoptose celular, na susceptibilidade ao melanoma cutâneo = Influence of the polymorphisms P53 ARG72PRO, MDM2 T309G, BCL2 C (-938) A and BAX G (-248) A, involved with cellular apoptosis, incutaneous melanoma susceptibility." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/308612.

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Orientador: Carmen Silvia Passos Lima
Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas.
Made available in DSpace on 2018-08-20T16:27:57Z (GMT). No. of bitstreams: 1 Oliveira_Cristianede_M.pdf: 2437379 bytes, checksum: 5fff08e294a7f4c2d2e6e49723726b29 (MD5) Previous issue date: 2012
Resumo: Os genes P53 e BAX (pró-apoptóticos) e MDM2 e BCL2 (antiapoptóticos) atuam na morte de células epiteliais danificadas por raios ultravioleta (UV) da luz solar e estão relacionados com a origem do melanoma cutâneo (MC). A proteína codificada pelo alelo selvagem Arg do polimorfismo P53 Arg72Pro induz melhor a apoptose do que a do alelo variante Pro. Os alelos variantes G e A dos polimorfismos MDM2 T309G e BCL2 C(-938)A e o alelo variante A do polimorfismo BAX G(-248)A estão relacionados com maior e menor expressão proteica, respectivamente, quando comparados aos alelos selvagens T, C e G. Como são incertos os papéis desses polimorfismos no risco e manifestações clínicas do MC, estes foram os principais objetivos do presente estudo. O DNA genômico de 150 pacientes e de 150 controles foi analisado por meio da reação em cadeia da polimerase e digestão enzimática. As frequências dos genótipos P53 ArgArg (58,7% vs 44,7%, P= 0,02) e BCL2 AA (28,0% vs 15,3%, P= 0,004) foram maiores em pacientes do que em controles. Portadores dos genótipos estiveram sob riscos 1,86 e 2,87 vezes maior de MC do que os demais, respectivamente. Excessos dos genótipos combinados P53 ArgArg + BCL2 AA (36,1% vs 16,9%, P= 0,002) e P53 ArgArg + BAX AA (29,5% vs 15,3%, P= 0,008) foram observados em pacientes comparados a controles. Indivíduos com os respectivos genótipos estiveram sob riscos 3,43 e 2,71 vezes maior de ocorrência do MC do que os demais, respectivamente. Concluímos que os polimorfismos P53Arg72Pro, BCL2 C(-938)A e BAX G(-248)A alteraram o risco de ocorrência do MC em nossa amostra e indivíduos com os genótipos ArgArg, AA e AA dos respectivos polimorfismos devem receber recomendações adicionais para proteção da pele dos efeitos nocivos dos raios UV e seguimento médico com exames dermatológicos periódicos, para prevenção e diagnóstico precoce do tumor
Abstract: The P53 and BAX (proapoptotic) and MDM2 and BCL2 (antiapoptotic) genes remove cells damaged by ultraviolet (UV) rays of the sunlight and, therefore, are related to the cutaneous melanoma (CM) origin. The Arg wild allele of the P53 Arg72Pro polymorphism is more efficient in inducing apoptosis than the variant Pro allele. The variant G and A alleles of the MDM2 T309G and BCL2 C(-948)A polymorphisms, and the A allele of the BAX G(-248) A polymorphism are related to higher and lower expressions of the encoded proteins, respectively, than the wild T, C and G wild alleles. Since the roles of the referred genetic polymorphisms on the risk and clinical manifestation of the tumor are still unclear, these were the main aims of the present study. Genomic DNA from 150 patients with CM and 150 controls was analyzed by polymerase chain reaction and enzymatic digestion. The frequencies of the P53 ArgArg and the BCL2 AA genotypes were higher in patients than in controls (58.7% versus 44.7%, P= 0.02) and (28.0% versus 15.3%, P= 0.004) respectively. Carriers of these genotypes had a 1.86 and 2.87-fold increased risks for MC than others, respectively. Excesses of the P53 ArgArg + BCL2 AA and P53 ArgArg + BAX AA were seen in patients when compared to controls (36.1% versus 16.9%, P= 0.002) and (29.5% versus 15.3%, P= 0.008), and carriers of these genotypes had a 3.43 and 2.71-fold increased risks for CM than others, respectively. We concluded that the P53 Arg72Pro, BCL2 C(-938)A and BAX G(-248)A polymorphisms alter the risk for CM in our sample. We believe that carriers of the ArgArg wild genotype and the variant AA genotypes of the respective genetic polymorphisms should receive additional recommendation to avoid exposition to sunlight and should be frequently evaluated by a dermatologist with the purpose of preventing and performing an early diagnosis of the disease, respectively
Mestrado
Biologia Estrutural, Celular, Molecular e do Desenvolvimento
Mestre em Fisiopatologia Médica

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Regler, Melanie [Verfasser], and Werner G. [Akademischer Betreuer] Daniel. "Antiatherosklerotische Eigenschaften von Resveratrol: Molekulare und funktionale Effekte auf humane Endothelzellen und Monozyten / Melanie Regler. Betreuer: Werner G. Daniel." Erlangen : Universitätsbibliothek der Universität Erlangen-Nürnberg, 2012. http://d-nb.info/1025963849/34.

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Cadan, Fellipe Magioli. "Otimização da síntese de nitreto de carbono grafítico e a formação de heteroestruturas com trióxido de tungstênio." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/75/75135/tde-29092017-172815/.

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Este estudo propôs uma avaliação do papel dos três principais parâmetros clássicos da síntese do nitreto de carbono grafítico: temperatura final, tempo de permanência na temperatura final e taxa de aquecimento. Realizou-se a otimização da síntese, via metodologia de superfície de resposta, usando-se como variável-resposta a degradação fotocatalítica de um poluente-modelo (tartrazina). A significância estatística dos fatores foi confirmada, com 95% de confiança. Em seguida, um modelo de segunda ordem foi ajustado às melhores respostas e, no ponto de máxima degradação, as condições foram: 605oC por 183 min, com taxa de aquecimento de 5oC min-1. A taxa de degradação com o fotocatalisador sintetizado foi aproximadamente três vezes maior que a da fotólise. As amostras da região de melhores respostas foram analisadas em uma série de experimentos de caracterização, sendo eles: difratometria de raios X, espectroscopia na região do infravermelho médio, área superficial específica, microscopias de varredura (MEV e MEV-FEG), potencial zeta e espectroscopia de reflectância difusa na região do ultravioleta-visível. O fotocatalisador com maior atividade apresentou menor energia de band gap e maior área superficial especifica do que as relatadas na literatura (2,59 eV e 29,5 m2 g-1, respectivamente). Foram criadas heteroestruturas entre o fotocatalisador sintetizado e o trióxido de tungstênio. A partir de uma série de caracterizações básicas, confirmou-se a formação da heteroestrutura. Com essa heteroestrutura, a taxa de degradação foi aproximadamente cinco vezes maior que a com o nitreto de carbono grafítico.
This study proposed an assessment of the role of the three major classical parameters for synthesizing graphitic carbon nitride: final temperature, residence time at the final temperature and heating rate. The synthesis was optimized, via response surface methodology, using the photocatalytic degradation of a model pollutant (tatrazine) as the response-variable. The statistical significance of the factors was confirmed, within 95% confidence level. Afterwards, a second-order model was adjusted to the better responses and, at the maximum degradation point, the conditions were: 605oC for 183 min, with heating rate of 5oC min-1. The degradation rate with the synthetized photocatalyst was approximately three times greater than the photolytic one. The samples from the better response region were analyzed in a series of characterization experiments: X ray diffractometry, mid-infrared spectrometry, specific surface area, scanning electron microscopy (SEM and FEG-SEM), zeta potential, and ultraviolet-visible diffuse reflectance spectroscopy. The most active photocatalyst showed smaller band gap energy and greater specific surface area than the ones reported in literature (2.59 eV and 29.5 m2 g-1, respectively). Heterostructures were formed between the synthetized photocatalyst and tungsten trioxide. A series of basic characterization techniques confirmed the heterostructure formation. Using this heterostructure, the degradation rate was approximately five times greater than the one with graphitic carbon nitride.

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Nash, Kevin T. "KISS1 matastasis suppressor secretion is required for metastasis suppression." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2006. https://www.mhsl.uab.edu/dt/2008r/nash.pdf.

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Sosa, Nancy Marcela perez. "Análise da expressão de genes regulados pela proteína Dermicidina nas células do melanoma maligno G-361 pelo método de DNA-microarray." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/5/5155/tde-24102014-124556/.

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A proteína dermicidina (DCD) é codificada por um gene localizado na porção 12q13 do cromossomo 12, presente apenas em primatas e humanos. A proteína é secretada por células de glândulas da pele, melanócitos, neurônios e células epiteliais da mama normal. Alguns estudos inciais revelaram a participação da proteína DCD em processos oncogênicos nos carcinomas de mama, próstata e melanoma pela sua capacidade de atuar como um fator de crescimento e sobrevivência celular. Nos estudos realizados no nosso laboratório mostramos que a DCD é expressa em células normais da pele, placenta, cérebro e em vários tumores, incluindo os carcinomas de mama e melanoma maligno. Ensaios biológicos e bioquímicos mostraram que o \"knockdown\" da expressão de DCD no melanoma maligno G-361 via RNA de interferência (RNAi) diminuiu significativamente o crescimento in vitro em cultura celular e a formação de tumores em camundongos Nude. Resultados similares foram obtidos quando camundongos Nude transplantados com células de melanoma G-361 foram tratados com anticorpos policlonais de coelhos contra a proteína DCD. Para compreender melhor o papel da proteína DCD na transformação de células de melanoma G-361 foram feitos ensaios de microarranjo de DNA para identificar os genes diferencialmente expressos entre as sublinhagens pLKO (controle) e IBC-I que expressa o shRNA para o mRNA da DCD. Entre os 374 genes alterados pelo silenciamento, encontramos 162 com expressão aumentada e 212 com a expressão reduzida. Os estudos de bioinformática pelo software MetaCore mostraram que o silenciamento do gene DNA modula as vias canônicas e redes de sinalização mediadas pelo receptores e ligantes da família BAFF/APRIL que contralam a ativação do fator de transcrição NF-kB, bem como para histonas envolvidas na remodelação da cromatina. Os níveis de expressão de mRNA de 9 genes de interesse foram validados por ensaios de RT-qPCR. Em uma segunda fase do estudo, foram analisadas as proteínas presentes em extratos nuclares dos clones pLKO e IBC-I de melanoma maligno G-361 por espectrometria de massas. Nos extratos proteicos da sublinhagem pLKO foram identificadas 74 proteínas nucleares, enquanto que na sublinhagem IBC-I foram identificadas 31 proteínas. Um grupo de 21 proteínas foi identificado em ambas sublinhagens. Estudos de bioinformática pelo programa STRING revelou que 14 das proteínas identificadas na sublinagem G-361-pLKO faziam interações diretas ou indiretas com a DCD. A rede formada por estas proteínas tem como centro a proteína p53, uma proteína chave na regulação do programa de morte celular e sobrevivência ao estresse oxidativo. Por outro lado, notou-se que a maioria das proteínas identificadas no extrato nuclear da sublinhagem IBC-I é da família das histonas e que poderiam atuar em complexos de remodelação da cromatina nas células G-361-IBC-I. Nossos resultados nos possibilitaram sugerir que futuros estudos sobre a expressão das histonas e suas modificações pós-traducionais poderão ajudar a desvendar o possível papel da DCD na regulação epigenética do melanoma e em outros tipos de cânceres
Dermcidin (DCD) is a human gene mapped to chromosome 12q13 region, only identified in primates and humans, and normally expressed in the eccrine glands of skin and brain. Several studies have confirmed that DCD-derived peptides contribute to innate and immune surveillance and in the oncogenic processes of breast, prostate and skin cancers, as revealed by its role as a growth factor and cell survival. We have further explored DCD function and its tumorigenic potential on skin melanocytes by specifically knocking down its expression in G-361 malignant melanoma cells via expressing constitutively short hairpin RNA against DCD mRNA. Biological and biochemical assays showed that the \"knockdown\" in the expression of DCD in G-361-pLKO control clone and a G-361-IBC-I clone expressing constitutively short hairpin RNA against DCD mRNA decreased significantly the in vitro growth in cell culture and tumor formation in nude mice. Similar results were obtained treating nude mice bearing G-361 melanoma xenografts with rabbit polyclonal antibodies against DCD protein. Here, we present a DNA microarray-based study that identified the genes that are up- and down-regulated in a G-361-pLKO control clone and a G-361-IBC-I clone expressing constitutively short hairpin RNA against DCD mRNA. A total of 372 genes differentially expressed were identified; being 162 genes up-regulated and 212 genes down-regulated. Bioinformatic studies showed that DCD gene silencing modulates canonical pathways and signaling networks mediated APRIL/BAFF receptors and ligands and NF-kB signaling pathway as well as chromatin remodeling mediated by histone family. The mRNA expression levels of 9 genes of interest were validated by RT-qPCR assays. Next we analyzed the proteins present in nuclear extracts from G-361- pLKO and G-361-IBC-I clones by mass spectrometry. We identified 74 proteins in the G-361-pLKO clone and 31 proteins in the G-361-IBC-I. A group of 21 proteins was identified in both sublineages. Bioinformatics analyses by STRING (Search Tool for the Retrieval of Interacting Genes/Proteins) platform showed that a small portion of the proteins identified only in G-361- pLKO cells was predicted to interact directly with DCD. The network formed by these proteins is centered in the p53 protein, a key regulator of survival and cell death program in response to DNA damage and oxidative stress. On the other hand, this network was completed abrogated using the nuclear protein from G-361-IBC-I because of absence of DCD protein. Since most of the proteins identified in nuclear extracts are of the histone family, it is likely that they are acting in the chromatin-remodeling complexes which are important to remodel nucleosomes of the G-361-IBC-I cells. Our results allowed us to suggest that future studies on the expression of histones and their posttranslational modifications may help to unravel the possible role of DCD in the epigenetic regulation of melanoma and other cancers

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Books on the topic "Melania G"

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Jacomo Tintoretto & i suoi figli: Storia di una famiglia veneziana / Melania G. Mazzucco. Milano: Rizzoli, 2009.

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Roger, Hobdell, ed. Freud, Jung, Klein-- the fenceless field: Essays on psychoanalysis and analytical psychology. London: Routledge, 1995.

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Pridgen, Melanie Gail. Botanical Coloring Book by Melanie G. Pridgen: Melanie G. Pridgen's Botanical Coloring Book. Independently Published, 2018.

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Pridgen, Melanie Gail. February Ink Drawings of Melanie G. Pridgen. Independently Published, 2019.

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Pridgen, Melanie Gail. The January Ink Drawings of Melanie G. Pridgen. Independently Published, 2019.

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Oldfield, Pamela. All About Melanie Brown (G K Hall Children's Audio Books). CHIVERS AUDIO BOOKS, 1992.

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Melanie Martin Goes Dutch: The Private Diary of My Almost Bummer Summer With Cecily, Matt the Brat, and Vincent Van Go G. Tandem Library, 2003.

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Fordham, Michael. Freud, Jung, Klein - The Fenceless Field: Essays on psychoanalysis and analytical psychology. Routledge, 1994.

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Freud, Jung, Klein - The Fenceless Field: Essays on Psychoanalysis and Analytical Psychology. Routledge, 1998.

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Book chapters on the topic "Melania G"

1

Liénard, D., F. Lejeune, and P. Ewalenko. "High dose of rTNFα with interferon-g and melphalan in isolation perfusion (ILP) for in transit melanoma metastases and recurrent soft tissue sarcoma." In Proceedings of the 3rd International Congress on Neo-Adjuvant Chemotherapy, 259–61. Paris: Springer Paris, 1991. http://dx.doi.org/10.1007/978-2-8178-0782-9_63.

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Sales, José Luis Espinosa. "UNA MUJER ENTRE EL DESEO Y LA LOCURA EN LA PALABRA DE MELANIA G. MAZZUCCO." In Encrucijadas en la cultura italiana., 65–72. Dykinson, 2022. http://dx.doi.org/10.2307/j.ctv2s0j64s.8.

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Zekeridou, Anastasia. "Behavioral and Cognitive Changes Followed by Coma." In Mayo Clinic Cases in Neuroimmunology, edited by Andrew McKeon, B. Mark Keegan, and W. Oliver Tobin, 86–89. Oxford University Press, 2021. http://dx.doi.org/10.1093/med/9780197583425.003.0026.

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A 60-year-old woman sought care for behavioral and cognitive changes over 1 week. She became irritable, could not run her daycare facility, and had short-term memory loss and. She was admitted to the hospital, where decreased consciousness developed over 2 to 3 days. She became comatose and needed to be intubated because of an aspiration event. Her clinical examination at admission showed short-term memory and attention deficits and generalized hyperreflexia without any meningeal signs or myoclonic jerks. She also had evidence of left axillary and retroclavicular lymphadenopathy. Magnetic resonance imaging of the brain showed T2 and fluid-attenuated inversion recovery bilateral hyperintensities in the caudate nuclei and putamina, without any diffusion abnormalities. Cerebrospinal fluid analysis showed lymphocytic, increased protein, and cerebrospinal fluid -restricted oligoclonal bands. Electroencephalography showed diffuse slowing with no epileptiform activity. Neural autoantibody testing was positive for immunoglobulin G antibodies to α‎-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor in the serum and cerebrospinal fluid by indirect tissue immunofluorescence and antigen-specific cell-based assays. Because of suspicion for paraneoplastic neurologic disease, positron emission tomography of the body was performed and showed hypermetabolic axillary, retropectoral, and retroclavicular lymph nodes. Lymph node biopsy showed metastatic melanoma of unknown primary. A diagnosis of paraneoplastic anti- α‎-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor encephalitis was made. The patient received treatment for melanoma (vemurafenib and cobimetinib) and encephalitis (intravenous methylprednisolone) and plasma, followed by rituximab. She remained intubated and unresponsive but subsequently recovered substantially. By 3 months the patient had minimal short-term memory loss; at 2-year follow-up her function had returned to baseline and her cancer was in remission. Anti-α‎-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor encephalitis can be severe, necessitating a protracted immunotherapy course and cancer treatment.

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Taber, Douglass F. "Stereoselective C-O Ring Construction: (+)-Pachastrissamine (Fujii/Ohno), Aspalathin (Minehan), (+)-Varitriol (Ghosh), Aspercyclide A (Spivey), Etnangien (Menche)." In Organic Synthesis. Oxford University Press, 2013. http://dx.doi.org/10.1093/oso/9780199965724.003.0051.

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(+)-Pachastrissamine 3, also known as jaspine B, induces apoptosis in melanoma cells by a caspase-dependent pathway. Nobutaka Fujii and Hiroaki Ohno of Kyoyo University developed (J. Org. Chem. 2010, 75, 3831) a practical route to 3 based on the Pd-mediated cyclization of 1 to 2. Thomas G. Minehan of California State University, Northridge, optimized (Organic Lett. 2010, 12, 1580) the condensation of 5 with the bis-pivalate 4. This opened a general route to C-aryl glycosides, including aspalathin 6. (+)-Varitriol 11 is vinylogously related to 7. A key step in the synthesis of 11 reported (J. Org. Chem. 2010, 75, 2107) by Subhash Ghosh of the Indian Institute of Chemical Technology was the intermolecular Heck coupling of 8 with 9. Aspercyclide A 14 and its more stable methyl ether are promising lead compounds for the treatment of asthma. In the course of a synthesis of 14, Alan C. Spivey of Imperial College developed (Chem. Commun. 2010, 1824) the intramolecular Heck cyclization of 12 to 13. In a bold synthesis of etnangien 17, Dirk Menche of Ruprecht-Karls-Universität Heidelberg showed (J. Org. Chem. 2010, 75, 2429) that the intramolecular Heck coupling of 15 to 16 proceeded efficiently. The substituents on 15 may be favoring conformations that lead to cyclization.

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Farne, Hugo, Edward Norris-Cervetto, and James Warbrick-Smith. "Diarrhoea." In Oxford Cases in Medicine and Surgery. Oxford University Press, 2015. http://dx.doi.org/10.1093/oso/9780198716228.003.0026.

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Strictly speaking, diarrhoea is an increase in the amount of stool passed daily to over 300 g of stool per day. This is usually accompanied by increased frequency and loosening of the stools. However, many patients will talk of ‘diarrhoea’ when they actually have melaena (dark, tarry stools from digested blood), steatorrhoea (pale, floating stools from undigested lipid), haematochezia (bright red stools from frank blood), or simply loose stools (soft faeces but no increase in frequency or quantity). Diarrhoea can be caused by: • Infection of the bowel (infectious diarrhoea) • Inflammation of the bowel (e.g. inflammatory bowel disease (IBD), diverticular disease) • Increased bowel motility (e.g. hyperthyroidism, anxiety, irritable bowel syndrome (IBS)) • Malabsorption of nutrients (e.g. coeliac disease, pancreatic insufficiency) • Obstruction overflow due to a mass allowing only liquid stool to pass beyond it (e.g. constipation—counterintuitively, hard faeces stuck in the bowel are a common cause of overflow diarrhoea in elderly people, colon cancer, ovarian cancer) • Medications (e.g. laxatives, colchicine, digoxin, metformin, thiazide diuretics, some antibiotics, etc.) For a young adult with acute diarrhoea, the most likely diagnoses are shown in Figure 20.1. Yes, it would. In elderly patients, neoplastic disease (villous polyps, colonic adenocarcinoma, pancreatic cancer), diverticular disease, overflow diarrhoea secondary to constipation, ischaemic colitis, microscopic colitis, and bacterial overgrowth (e.g. in patients with diabetes mellitus) are much more likely, whereas coeliac disease is less likely to present for the first time (as it tends to present in younger patients). Curiously, ulcerative colitis (UC) and Crohn’s disease are thought to have a bimodal distribution in incidence, with peaks at 15–25 and 50–80 years. • Airway, breathing, and circulation (ABC): always, always, always start the management of a patient with ABC. Although the ABCs will be obviously normal in a large number of patients presenting in a non-emergency setting, you should always keep this in mind when admitting patients to hospital. Note that hypotension is a late and worrying sign in young patients. • Dehydration: in a patient with a 3-day history of diarrhoea, one should be concerned about the possibility of dehydration (hypovolaemia).

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Conference papers on the topic "Melania G"

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Pinheiro, Silviane Bezerra, NAIRA SULANY OLIVEIRA DE SOUSA, and JOÃO VICENTE BRAGA DE SOUZA. "PRODUÇÃO DE MELANINA POR CRYPTOCOCCUS GATTII EM DIFERENTES MEIOS DE CULTURAS." In II Congresso Nacional de Microbiologia Clínica On-line. Revista Multidisciplinar em Saúde, 2022. http://dx.doi.org/10.51161/ii-conamic/19.

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Introdução: Atualmente, o gênero Cryptococcus possui mais de 30 espécies descritas, mas apenas o complexo de espécies Cryptococcus neoformans/ Cryptococcus gattii podem causar infecção em animais e seres humanos. Os principais reservatórios desses fungos são as árvores e o solo. A infecção ocorre a partir de inalação de aerossóis contendo leveduras ressecadas ou basidiósporos. A coloração da melanina auxilia no isolamento ambiental, sendo responsável pela diferenciação da cor da levedura que fica com uma coloração marrom brilhante. Objetivo: Em busca por um meio de cultura que forneça a rápida detecção de Cryptococcus sp., esse estudo verificou a produção de melanina em quatro tipos de meios de cultura. Metodologia: Nesse experimento utilizou-se a cepa de referência CFP60 de C. gattii . Após 24 horas de crescimento em agar Saboraud foi realizado uma suspensão das células em solução salina 0,85 % e inóculo de 0,5 na escala de MacFarland. A infecção do solo foi feita com 1 mL do inóculo em 10 g de solo. Posteriormente, 1 g do solo foi transferido para 50 mL de solução salina 0,9%, ficou sob agitação (150 rpm/5minutos) e repouso por 30 minutos. Um volume de 100 µL foi semeado nos seguintes meios: 1) agar semente de girassol (100 g semente de girassol, 5 g de glicose, 400 mg de antibiótico, 15 g de agar); 2) agar casca de berinjela (50 g de casca de berinjela, 1 g de glicose, 400 mg de antibiótico, 15 g de agar); 3) agar polpa de banana (400 g de polpa de banana, 1 g de glicose, 400 g de antibiótico, 15 g de agar); 4) agar serrapilheira (100 g de serrapilheira desidratada e triturada, 20 g de glicose, 400 g de antibiótico, 15 g de agar) para 1000 mL de água destilada. Resultados: Após dois dias de crescimento, em temperatura ambiente, foi detectado produção de melanina no meio agar semente de girassol e os demais meios no quarto dia. Conclusão: Com isso, pudemos observar que os compostos fenólicos dos substratos utilizados nos meios de cultura influenciam no tempo de produção de melanina por C. gattii, destacando o agar semente de girassol.

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Rodzkin, A. S., T. S. Erchinskaya, and N. V. Ikonnikova. "BIOCHEMICAL CHARACTERISTICS OF THE COMPONENT COMPOSITION OF FRUIT BODIES OF MEDICINAL BASIDIOMYCETES." In SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY. International Sakharov Environmental Institute of Belarusian State University, 2021. http://dx.doi.org/10.46646/sakh-2021-2-96-99.

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The content of the main biochemical components: protein, polysaccharides, lipids, melanin pigments, and phenolic compounds was studied in the fruit bodies of strains of fungi of the genera Ganoderma, Inonotus, Phallus, and Pleurotus. The amount of total and true protein was 14.6-28.0% and 10.9-18.5%, respectively, polysaccharides-10.8-28.4%, lipids-3.1-3.5%, phenolic compounds-580-2200 mg%. Higher protein content was observed in the strains of the fungus P. ostreatus, polysaccharides - in the strains of G. lucidum and Ph. impudicus, phenolic compounds in the strains of the fungus I. obliquus. The largest amount of polysaccharides (22.0-24.0 %) was isolated from the fruit bodies of G. lucidum (reishi). The leader in the content of polysaccharides in the dry biomass of fruit bodies is the fungus Phallus impudicus (common Veselka). The fruit bodies of Chaga I. obliquus (strains KI 5, KI 7) and Veselka Ph. impudicus (strains PI 2, PI 5, and PI 9) contained significant amounts of melanin pigments - 10.3-13.8% and 7.1-7.4%, respectively.

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Satyana, A. H. "Ciletuh Subduction, West Java - New Findings, New Problems: Regional Implications to Cretaceous-Paleogene Convergence of Sundaland Margin and Its Petroleum Geology." In Indonesian Petroleum Association 44th Annual Convention and Exhibition. Indonesian Petroleum Association, 2021. http://dx.doi.org/10.29118/ipa21-g-29.

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Ciletuh, southwest Java has been well known as one of the places in Java where pre-Tertiary basement rocks are exposed (Verbeek and Fennema, 1896; Duyfjes, 1940; van Bemmelen, 1949; Sukamto, 1975). In plate tectonic point of view, Ciletuh has been known as place outcropping melange complex related to pre-Tertiary oceanic plate subduction (Thayyib et al., 1977). Ciletuh subduction regionally has been linked to the Cretaceous subduction zones of Luk Ulo/Karang Sambung (Central Java) and Meratus Mountains (South Kalimantan) (Hutchison, 1973; Asikin 1974; Hamilton, 1979). Ciletuh subduction however, has not been dated using metamorphic rocks formed in its subduction zone. Its link to Luk Ulo and Meratus subduction zone only based on the presence of melange, which also lacks of data Meanwhile, subduction zones of Luk Ulo and Meratus have been dated and analysed. We herewith present the results of new field studies and various analyses carried out in the last five years of the Ciletuh subduction complex. The indication of Cretaceous subduction has not found from the date measurement, Ciletuh shows Eocene related subduction. Most of the ophiolites were island-arc tholeiitic or island-arc basalt formed in supra-subduction zone. The overlying olistostrome deposits were younger than previously considered and lasted until early/middle Miocene. Some of the basaltic pillowed lava is considered as part of the ophiolite, while the ones at Gunung Badak is more likely a part of the early Miocene Jampang volcanism. Link of Ciletuh to Early Cretaceous subduction of Luk Ulo is not supported by geochronological data. The new knowledge of Ciletuh subduction implies the pre-Tertiary and Paleogene geology of Java, and petroleum prospectivities of the Paleogene objectives of southern West Java. New problems arise and need more field data and analyses to find out the answers.

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Badaruddin, D. F. "Sintang Intrusive Delineation and Focus Area for Hydrocarbon Exploration in Melawi Basin, West Kalimantan." In Indonesian Petroleum Association 42nd Annual Convention and Exhibition. Indonesian Petroleum Association, 2018. http://dx.doi.org/10.29118/ipa19.g.172.

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Rånby, M., A. Brändstrôm, L. Hansen, K. Henson, and G. Larsen. "REC. t-PA GENETICALLY MODIFIED AT THE CLEAVAGE SITE OF ONE-CHAIN TO TWO-CHAIN CONVERSION: ENZYMOLOGY AND DIAGNOSTIC APPLICATIONS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644410.

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Native one-chain t-PA is cleaved by plasmin or by trypsin after the Arg in the sequence -Gln-Phe-Arg-Ile-Lys-. Variants of one-chain t-PA where the -Arg- was replaced by a His (Arg to His) or by a Lys (Arg to Lys) or by a Thr (Arg to Thr) were made through genetic modification. The three mutants and the wild type were expressed in animal cells and purified in the one-chain form by affinity chromatography as was t-PA from Bowes melanoma cells. In contrast to wild type and melanoma t-PA the mutants reacted poorly with polyclonal antibodies raised against the peptide -Gln-Pro-Gln-Phe-Arg-Ile-Lys--Gly-Gly- indicating mutation in the sequence. Of these proteins only the Arg to Thr mutant was resistant to plasmin cleavage as evidenced by SDS-PAGE. t-PA antigen values (ELISA) and fibrinolytic activity values (fibrin clot lysis assay) yielded the following specific activities expressed in IU/|μg: 810 (Arg to His), 640 (Arg to Lys), 290 (Arg to Thr), 810 (wild type) and 660 (melanoma t-PA). The amidolytic activities for the one-chain proteins against D-Ile-Pro-Arg-pNA at pH 9.0 and 37°C, expressed in mOD per minute at 1 M-g/mL of enzyme were: 15.8 (Arg to His), 13.6 (Arg to Lys), 8.3 (Arg to Thr), 10.0 (wild type), 9.6 (melanoma t-PA) as compared to 55.2 for two-chain melanoma t-PA.All mutants including the uncleavable Arg to Thr mutant could be used in determination of PAI activity in plasma samples. Only one-chain t-PA reacts selectively with PAI 1. Thus, use of the Arg to Thr mutant represents a theoretical advantage in PAI 1 activity determination since preparations of this mutant most likely is free of contaminating two-chain t-PA.The plasminogen activation rate as measured in a coupled assay in the presence and absence of fibrin at 0.5 jiM plasminogen and 37°C was measured and the stimulation factor calculated. This was about 950 fold for the Arg to Thr mutant wich was considerably higher than that of melanoma one chain t-PA and the other mutants wich all were about 550 fold. The stimulation factor for melanoma two-chain t-PA was in the same experiment about 120 fold. The extra fibrin sensitivity of the Arg to Thr mutant resulted in improved soluble fibrin assay according to Wiman and Renby Thromb. Haemostas, (1986) 55:189-193.In conclusion: the use of a plasmin insensitive protein-engineered mutant of t-PA gives advantages in assays for PAI 1 and soluble fibrin.

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Prickett, Todd D., Xiaomu Wei, Isabel Cardenas-Navia, Jamie Teer, Jimmy C. Lin, Vijay Walia, Jared Gartner, et al. "Abstract 4860: Exon capture analysis of G-protein coupled receptors reveals activating mutations inGRM3in melanoma." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-4860.

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Jaramillo, Haidee, Romel Jesús Gallardo Amaya, and Ciro Andrey Martínez Ovallos. "Variación de la consistencia del concreto mediante la adición de melaza de caña." In Nuevas realidades para la educación en ingeniería: currículo, tecnología, medio ambiente y desarrollo. Asociación Colombiana de Facultades de Ingeniería - ACOFI, 2022. http://dx.doi.org/10.26507/paper.2455.

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Abstract:

El concreto es uno de los materiales de construcción de mayor demanda debido a sus propiedades y versatilidad, adicionalmente, es común que se empleen diversos aditivos que permiten modificar el comportamiento y la estructura del concreto, potenciando o reduciendo ciertas características que constituyen un beneficio para las obras. Son diversas las investigaciones que se han desarrollado para buscar soluciones alternativas al uso de aditivos a partir de materiales poco convencionales y de menor costo, diversos autores han documentado las bondades del uso de productos derivados del azúcar, logrando potenciar la resistencia y durabilidad del concreto o los morteros. El uso de melaza como superplastificante ha permitido una disminución en la dembanda de agua adicionada en la mezcla para mantener la trabajabilidad, por lo tanto, se reduce la relación agua-cemento efectiva y se mejoran las propiedades del concreto. Además, se ha demostrado que los tiempos de fraguado de las pastas de cemento aumentan con el aumento del contenido de melaza. Resulta evidente que el uso del azúcar y sus derivados son una alternativa viable para mejorar las propiedades del concreto, contribuyendo principalmente a la trabajabilidad de la mezcla y ampliar el tiempo de fraguado. No obstante, en Colombia son pocos los estudios que específicamente analizan la influencia de la melaza proveniente de la caña de azúcar y en mezclas de concreto. Lo anterior ha motivado el desarrollo de esta investigación, en la cual se analizó la incorporación de la melaza en dosificaciones que van desde el 0% al 1%, que, como se ha evidenciado en la literatura, logra mejorar características como la trabajabilidad y ampliación del tiempo de fraguado. Además, constituye una alternativa sostenible, puesto que emplea un material orgánico como lo es la caña de azúcar, la cual hace parte de la producción agrícola en varias regiones del país. Se realizó la incorporación de melaza en mezclas de concreto convencional diseñado con una relación a/c de 0.54 y una consistencia media para asentamientos entre 50 y 100 mm, en dosificaciones de 0.2%, 0.4%, 0.6%, 0.8% y 1.0% respecto a la cantidad de agua. La melaza es de uso comercial con un peso específico de 1.4 g/cm3, un PH de 5.0 y una humedad del 26%. Los resultados obtenidos indican que para las dosificaciones del 0.4% de melaza se logran una consistencia del concreto en términos de asentamientos de hasta 3.2 cm pasados 60 minutos desde el mezclado, valor que supera a la mezcla de control con la cual no se obtuvo ningún valor de asentamiento a los 60 minutos. Adicionalmente, la consistencia del concreto con aditivo comercial respecto al concreto con 1% de melaza tiene una variación porcentual del 20% inmediatamente después del mezclado, lo cual indica, que la melaza de caña alcanza valores cercanos a los obtenidos con plastificantes de uso comercial luego del proceso de mezclado.

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Chhabra, Gagan, Luke Wojdyla, Ankita Sanjali, Mark Frakes, Marko Ivancich, Pooja Vinay, Zachary Schrank, Benjamin E. Ramirez, and Neelu Puri. "Abstract 4128: Mechanism of action of G-quadruplex forming oligonucleotide homologous to the telomere overhang in melanoma." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-4128.

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Belizario, Jose E., and Marcela Perez. "Abstract 3018: Identification of genes up-and down-regulated by dermcidin in G-361 malignant melanoma cell line." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-3018.

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Neyra, Jennifer Montoya, and Jose Belizario. "Abstract B19: Modulation of cytotoxic effects of vemurafenib by chloroquine in malignant melanoma cells G-361: Role of dermcidin." In Abstracts: AACR Special Conference on Tumor Immunology and Immunotherapy; October 1-4, 2017; Boston, MA. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/2326-6074.tumimm17-b19.

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