Journal articles on the topic 'Meierei C'
To see the other types of publications on this topic, follow the link: Meierei C.
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 journal articles for your research on the topic 'Meierei C.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.
1
Hinshaw, Robert. "Carl Alfred (C. A.) Meier: April 19, 1905 - November 15, 1995." San Francisco Jung Institute Library Journal 14, no. 4 (January 1996): 77–78. http://dx.doi.org/10.1525/jung.1.1996.14.4.77.
Full text
2
Ely, John J., Tony Zavaskis, and M. Lon Lammey. "Censored Data Analysis Reveals Effects of Age and Hepatitis C Infection on C-Reactive Protein Levels in Healthy Adult Chimpanzees (Pan troglodytes)." Journal of Biomarkers 2013 (February 27, 2013): 1–13. http://dx.doi.org/10.1155/2013/709740.
Full textAbstract:
C-reactive protein, a conserved acute-phase protein synthesized in the liver and involved in inflammation, infection, and tissue damage, is an informative biomarker for human cardiovascular disease. Out of 258 captive adult common chimpanzees (Pan troglodytes) assayed for CRP, 27.9% of the data were below the quantitation limit. Data were analyzed by the Kaplan-Meier method and results compared to other methods for handling censored data (including deletion, replacement, and imputation). Kaplan-Meier results demonstrated a modest age effect and a strong effect of HCV infection in reducing CRP but did not allow inference of reference intervals. Results of other methods varied considerably. Substitution schemes differed widely in statistical significance, with estimated group means biased by the size of the substitution constant, while inference of unbiased reference intervals was impossible. Single imputation gave reasonable statistical inferences but unreliable reference intervals. Multiple imputation gave reliable results, for both statistical inference and reference intervals, and was comparable to the Kaplan-Meier standard. Other methods should be avoided. CRP did not predict cardiovascular disease, but CRP levels were reduced by 50% in animals with hepatitis C infection and showed inverse relationships with 2 liver function enzymes. Results suggested that hsCRP can be an informative biomarker of chronic hepatic dysfunction.
3
Inglis, R., M. Pannike, A. Pannike, J. Windolf, and M. Lorenz. "Berechnung und grafische Darstellung der Produktmomentkorrelation nach KAPLAN-MEIER mit dem Personalcomputer - Programm KAPLGRAPH(c)." Biomedizinische Technik/Biomedical Engineering 35, s2 (1990): 166. http://dx.doi.org/10.1515/bmte.1990.35.s2.166.
Full text
4
Bergoli, CD, LP Brondani, VF Wandscher, GKR Pereira, MS Cenci, T. Pereira-Cenci, and LF Valandro. "A Multicenter Randomized Double-blind Controlled Clinical Trial of Fiber Post Cementation Strategies." Operative Dentistry 43, no. 2 (March 1, 2018): 128–35. http://dx.doi.org/10.2341/16-278-c.
Full textAbstract:
SUMMARY Objectives: The aim of this prospective randomized multicenter clinical trial was to evaluate the survival rate of glass fiber–reinforced posts cemented with self-adhesive or regular resin cements. Methods: The sample was comprised of 152 teeth randomized within two centers and in accordance with the adhesive strategies for RelyX U100/U200 (3M ESPE) or Single Bond and RelyX ARC (3M ESPE). The cementation procedures were standardized and performed by previously trained operators. The primary outcome evaluated was post debonding. A trained evaluator, one for each center, assessed all subjects at intervals of 12 months for up to 6 years. Statistical analysis was performed using the Kaplan-Meier method. Results: There was no statistically significant difference in survival rates between the two strategies assessed (p=0.991), with a 92.7% survival rate for the self-adhesive cement and 93.8% for the regular cement. Conclusion: Both the self-adhesive and the regular resin cements are good alternatives for glass fiber post cementation.
5
Halfter, Carl. "C. A. Meier, Der Traum als Medizin. Antike Inkubation und moderne Psychotherapie. Daimon Verlag, Zürich 1985." Gesnerus 42, no. 3-4 (November 19, 1985): 517–18. http://dx.doi.org/10.1163/22977953-0420304030.
Full text
6
Mohammadshahi, Jafar, Hassan Ghobadi, Golchin Matinfar, Mohammad Hossein Boskabady, and Mohammad Reza Aslani. "Role of Lipid Profile and Its Relative Ratios (Cholesterol/HDL-C, Triglyceride/HDL-C, LDL-C/HDL-C, WBC/HDL-C, and FBG/HDL-C) on Admission Predicts In-Hospital Mortality COVID-19." Journal of Lipids 2023 (March 6, 2023): 1–10. http://dx.doi.org/10.1155/2023/6329873.
Full textAbstract:
Background. Lipid profile and its related ratios such as total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), triglyceride (TG), high-density lipoprotein-cholesterol (HDL-C), TG/HDL-C ratio, TC/HDL-C ratio, LDL-C/HDL-C ratio, white blood cell (WBC)/HDL-C ratio, and fasting blood glucose (FBG)/HDL-C ratio are valuable indicators that have been studied in various disorders to predict mortality. The present study was conducted with the aim of investigating the role of lipid profile ratios in predicting mortality in COVID-19 patients. Methods. At the beginning of hospitalization, laboratory tests were taken from all patients ( n = 300 ). The ability of lipid profile ratios to determine the COVID-19 severity was evaluated using receiver-operating characteristic (ROC). In addition, survival probability was determined with the average of Kaplan-Meier curves, so that the end point was death. Results. In deceased patients, TG, TC, LDL-C, HDL-C, TC/HDL-C, TG/HDL-C, and LDL-C/HDL-C parameters were significantly lower than those of surviving patients, while WBC/HDL-C and FBG/HDL-C were significantly higher. TC ( HR = 3.178 , 95 % CI = 1.064 to 9.491, P < 0.05 ), TG ( HR = 3.276 , 95 % CI = 1.111 to 9.655, P < 0.05 ), LDL-C ( HR = 3.207 , 95 % CI = 1.104 to 9.316, P < 0.05 ), and HDL-C ( HR = 3.690 , 95 % CI = 1.290 to 10.554, P < 0.05 ), as well as TC/HDL-C ( HR = 3.860 , 95 % CI = 1.289 to 11.558, P < 0.05 ), TG/HDL-C ( HR = 3.860 , 95 % CI = 1.289 to 11.558, P < 0.05 ), LDL-C/HDL-C ( HR = 3.915 , 95 % CI = 1.305 to 11.739, P < 0.05 ), WBC/HDL-C ( HR = 3.232 , 95 % CI = 1.176 to 8.885, P < 0.05 ), and FBG/HDL-C ratios ( HR = 4.474 , 95 % CI = 1.567 to 12.777, P < 0.01 ), were detectably related to survival. The multivariate Cox regression models showed that only FBG/HDL-C ratio ( HR = 5.477 , 95 % CI = 1.488 to 20.153, P < 0.01 ) was significantly related to survival. Conclusion. The results suggested that FBG/HDL-C ratio in hospital-admitted COVID-19 patients was a reliable predictor of mortality.
7
Balasov, Maxim, Katarina Akhmetova, and Igor Chesnokov. "Drosophilamodel of Meier-Gorlin syndrome based on the mutation in a conserved C-Terminal domain of Orc6." American Journal of Medical Genetics Part A 167, no. 11 (July 2, 2015): 2533–40. http://dx.doi.org/10.1002/ajmg.a.37214.
Full text
8
Kim, J.-H., J. Cho, Y. Lee, and B.-H. Cho. "The Survival of Class V Composite Restorations and Analysis of Marginal Discoloration." Operative Dentistry 42, no. 3 (May 1, 2017): E93—E101. http://dx.doi.org/10.2341/16-186-c.
Full textAbstract:
SUMMARY The aims of this retrospective clinical study were to analyze the longevity of class V composite restorations and compare the results obtained from clinical and laboratory evaluation of marginal discoloration. A total of 186 restorations were evaluated with modified US Public Health Service criteria. Longevity and associated variables were analyzed with the Kaplan-Meier method and a Cox proportional hazard model. Restorations with marginal discoloration were additionally evaluated using digital photographs and epoxy resin replicas under a stereomicroscope. The mean survival time was 15.0 years, with five- and 10-year survival rates of 95.5% and 83.1%, respectively. Z250 had a higher risk of failure (hazard ratio=7.01, 95% confidence interval=2.07-23.72) than Z100. In addition, the presence of occlusal wear facets and bleeding on probing were associated with an increased risk of failure of the restorations. However, the use of an adhesive system (Scotchbond Multi-Purpose or Clearfil SE Bond) did not affect the longevity of the restorations. The results of laboratory evaluation were significantly different from clinical evaluation (p<0.001, McNemar test). Among 55 restorations rated as Bravo in the clinical evaluation, 24 restorations (43.6%) were determined to have penetrating discoloration on laboratory evaluation. When evaluating aged composite restorations, surface refurbishment and the use of a microscope are recommended, which will be helpful in determining the need for timely repair or replacement.
9
Chiu, Vi Kien, and Adele Lerolle-Chiu. "Integrated survival analysis." Journal of Clinical Oncology 41, no. 16_suppl (June 1, 2023): e14695-e14695. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e14695.
Full textAbstract:
e14695 Background: Clinical trial efficacy may be determined by the primary endpoint(s) of median progression free survival (mPFS) and/or median overall survival (mOS) from the Kaplan-Meier estimate, and secondary endpoints of overall response rate (ORR) and duration of response (DOR). In the treatment of metastatic cancers, single agent immunotherapy tends to have lower ORR and longer DOR in comparison to chemotherapy or targeted tyrosine kinase inhibitor therapy, which tends to have higher ORR and shorter DOR. This leads to intersecting or crossing Kaplan-Meier survival curves, which are harder to interpret. In immunotherapy trials, mPFS is a poor surrogate for mOS, and both may underrepresent the clinical benefit over time. Methods: We aimed to develop novel metrics that more effectively represent the Kaplan-Meier estimate. The graphical curve of the Kaplan-Meier estimate may be represented by the equation as a function of time. The integration of f ( x), which mathematically represents the area under the curve and clinically the cumulative or integrated survival benefit with time, is: ∫0t f( x) dx = F(t) − F(0). Kaplan-Meier curve equation with constants C and A may be approximated by: ∫0t C e-A x dx = C e-A t ]0 t = C( e-A t – 1). The average integrated clinical benefit with time is: 1/ t ∫0t f( x) dx = [ F( t) − F(0)]/ t. Results: The Phase 3 KeyNote-061 trial of metastatic gastric cancer treated with single agent Pembrolizumab immunotherapy versus Paclitaxel chemotherapy was use for integrated PFS and iOS calculation. The Kaplan-Meier curves intersected or crossed in KeyNote-061 trial. We show the established ORR, mPFS, mOS, DOR. Integrated PFS (iPFS) and iOS were calculated with greater increase in iOS and much less decrease in iPFS for Pembrolizumab than Paclitaxel treatment. Conclusions: Integrated survival is a novel analysis that integrate the Kaplan Meier estimates and better represent the entire median survival and drug DOR may be combined into a single useful metric for overall clinical benefit. [Table: see text]
10
Nazarenko, Maria S., Iuliia V. Viakhireva, Mikhail Y. Skoblov, Elena V. Soloveva, Aleksei A. Sleptcov, and Ludmila P. Nazarenko. "Meier–Gorlin Syndrome: Clinical Misdiagnosis, Genetic Testing and Functional Analysis of ORC6 Mutations and the Development of a Prenatal Test." International Journal of Molecular Sciences 23, no. 16 (August 17, 2022): 9234. http://dx.doi.org/10.3390/ijms23169234.
Full textAbstract:
Meier–Gorlin syndrome (MGS) is a rare genetic developmental disorder that causes primordial proportional dwarfism, microtia, the absence of or hypoplastic patellae and other skeletal anomalies. Skeletal symptoms overlapping with other syndromes make MGS difficult to diagnose clinically. We describe a 3-year-old boy with short stature, recurrent respiratory infections, short-rib dysplasia, tower head and facial dysmorphisms who was admitted to the Tomsk Genetic Clinic to verify a clinical diagnosis of Jeune syndrome. Clinical exome sequencing revealed two variants (compound heterozygosity) in the ORC6 gene: c.2T>C(p.Met1Thr) and c.449+5G>A. In silico analysis showed the pathogenicity of these two mutations and predicted a decrease in donor splicing site strength for c.449+5G>A. An in vitro minigene assay indicated that variant c.449+5G>A causes complete skipping of exon 4 in the ORC6 gene. The parents requested urgent prenatal testing for MGS for the next pregnancy, but it ended in a miscarriage. Our results may help prevent MGS misdiagnosis in the future. We also performed in silico and functional analyses of ORC6 mutations and developed a restriction fragment length polymorphism and haplotype-based short-tandem-repeat assay for prenatal genetic testing for MGS. These findings should elucidate MGS etiology and improve the quality of genetic counselling for affected families.
11
Rho, Y.-J., C. Namgung, B.-H. Jin, B.-S. Lim, and B.-H. Cho. "Longevity of Direct Restorations in Stress-Bearing Posterior Cavities: A Retrospective Study." Operative Dentistry 38, no. 6 (November 1, 2013): 572–82. http://dx.doi.org/10.2341/12-432-c.
Full textAbstract:
SUMMARYThe aims of this retrospective clinical study were to compare the longevities of direct posterior amalgam restorations (AMs) and resin composite restorations (RCs) that were subjected to occlusal stresses and to investigate variables predictive of their outcome. A total of 269 AMs and RCs filled in Class I and II cavities of posterior teeth were evaluated with Kaplan-Meier survival estimator and multivariate Cox proportional hazard model. Seventy-one retreated restorations were reviewed from dental records. The other 198 restorations still in use were evaluated according to modified US Public Health Service (USPHS) criteria by two investigators. The longevity of RCs was significantly lower than that of AMs (AM = 8.7 years and RC = 5.0 years, p<0.05), especially in molars. The prognostic variables, such as age, restorative material, tooth type, operator group, diagnosis, cavity classification, and gender, affected the longevity of the restorations (multivariate Cox regression analysis, p<0.05). However, among the restorations working in oral cavities, their clinical performance evaluated with modified USPHS criteria showed no statistical difference between both restoratives. In contrast to the short longevity of RCs relative to AMs, the clinical performance of RCs working in oral cavities was observed to be not different from that of AMs. This suggests that once a RC starts to fail, it happens in a rapid progression. As posterior esthetic restorations, RCs must be observed carefully with periodic follow-ups for early detection and timely repair of failures.
12
Munoz-Sanchez, ML, M. Bessadet, C. Lance, G. Bonnet, JL Veyrune, E. Nicolas, M. Hennequin, and N. Decerle. "Survival Rate of CAD–CAM Endocrowns Performed by Undergraduate Students." Operative Dentistry 46, no. 5 (September 1, 2021): 505–15. http://dx.doi.org/10.2341/20-126-c.
Full textAbstract:
SUMMARY Objectives: This study aimed to evaluate the success of computer-aided design–computer-aided manufacturing (CAD–CAM) endocrown restorations of endodontically treated teeth (ETT) performed by supervised undergraduate students. The study also intended to identify possible factors that may lead to failures. Methods and Materials: This observational open cohort study was based on clinical data from endocrown restorations performed by residents and undergraduate students in their 4th, 5th, and 6th year from July 2011 to May 2018. The presence of a tooth with an endocrown on the arch was the main criteria used to calculate the survival rate of restored teeth. The quality of the remaining endocrowns was evaluated referring to the FDI criteria. The cases of failure were categorized into either favorable or unfavorable. Results: A total of 343 ETT were restored with endocrowns in 315 patients. Among them, 199 patients encompassing 225 endocrowns were followed during a 56 ± 26 month period. The survival rate of restored teeth was found to be 81.8%, the estimated Kaplan–Meier survival rate being 71.8% at 9 years. Among the 41 failed cases, 32 were favorable (debonding and/or ceramic fractures) and 9 were unfavorable. Conclusion: Endocrown restorations of posterior ETT using CAD–CAM technologies could be carried out by undergraduates with a low risk of failure. Teacher supervision could be reinforced, covering all steps of each endocrown procedure in order to avoid failures due to insufficient thickness or loss of retention.
13
Rocha, AC, MM Suca Salas, AS Masotti, WLO da Rosa, CH Zanchi, and RG Lund. "A Randomized Double-blind Clinical Trial of Dentin Surface Treatments for Composite Restorations in Noncarious Cervical Lesions: A 36-month Evaluation." Operative Dentistry 44, no. 2 (March 1, 2019): 114–26. http://dx.doi.org/10.2341/17-308-c.
Full textAbstract:
SUMMARY Objective: This randomized, double-blind clinical trial aimed to evaluate the influence of different dentin surface treatments in noncarious cervical lesions (NCCLs). Methods and Materials: Twenty-nine patients participated in this study. One hundred sixty-five NCCLs were selected and randomly assigned to three groups: G0 (control group) with phosphoric acid etching for 15 seconds; G1: phosphoric acid etching for 30 seconds; and G2: ultrasound probe applied for 30 seconds on the dentin surface. Class V composite resin restorations were performed (Z350, 3M ESPE, St Paul, MN, USA). The restorations were evaluated at baseline and at six, 12, 24, and 36 months according to the World Dental Federation criteria. Survival curves were obtained using the Kaplan-Meier method and the log-rank test. Comparisons between groups and times were performed using the McNemar and Chi-square tests (α=0.05). Results: The presence of failures due to retention was statistically different among the groups (p=0.012), and G0 and G2 showed better clinical performance than did G1. Sensitivity decreased over time in all groups. Marginal discoloration, postoperative sensitivity, and marginal adaptation were not different among the groups (p>0.05). Conclusions: The studied dentin surface treatments showed similar clinical performance to the conventional technique at 36 months in terms of marginal discoloration, marginal adaptation, and postoperative sensitivity. In contrast, increased acid-etching time resulted in a higher risk of failure due to retention over time in composite Class V restorations.
14
Wong, J. B., K. Hino, F. Kurokawa, S. Nishina, I. Sakaida, K. Okita, T. Tamesa, et al. "Validating a Markov Model of Treatment for Hepatitis C Virus-related Hepatocellular Carcinoma." Methods of Information in Medicine 47, no. 06 (2008): 529–40. http://dx.doi.org/10.3414/me9124.
Full textAbstract:
Summary Objective: We created and validated a Markov model to simulate the prognosis with treatment for HCV-related hepatocellular carcinoma (HCC) for assessment of cost-effectiveness for alternative treatments of HCC. Method: Markov state incorporated into the model consisted of the treatment as a surrogate for HCC stage and underlying liver function. Retrospective data of 793 patients from three university hospitals were used to determine Kaplan-Meier survival curves for each treatment and transition probabilities were derived from them. Results: There was substantial overlap in the 95% CIs of the Markov model predicted and the Kaplan-Meier survival curves for each therapy. The predicted survival curves were also similar with those from the nationwide survey data supporting the external validity of our model. Conclusions: Our Markov model estimates for prognosis with HCC have both internal and external validity and should be considered applicable for estimating cost-effectiveness related to HCC.
15
Hemilä, Harri, and Elizabeth Chalker. "Bias against Vitamin C in Mainstream Medicine: Examples from Trials of Vitamin C for Infections." Life 12, no. 1 (January 3, 2022): 62. http://dx.doi.org/10.3390/life12010062.
Full textAbstract:
Evidence has shown unambiguously that, in certain contexts, vitamin C is effective against the common cold. However, in mainstream medicine, the views on vitamin C and infections have been determined by eminence-based medicine rather than evidence-based medicine. The rejection of the demonstrated benefits of vitamin C is largely explained by three papers published in 1975—two published in JAMA and one in the American Journal of Medicine—all of which have been standard citations in textbooks of medicine and nutrition and in nutritional recommendations. Two of the papers were authored by Thomas Chalmers, an influential expert in clinical trials, and the third was authored by Paul Meier, a famous medical statistician. In this paper, we summarize several flaws in the three papers. In addition, we describe problems with two recent randomized trial reports published in JAMA which were presented in a way that misled readers. We also discuss shortcomings in three recent JAMA editorials on vitamin C. While most of our examples are from JAMA, it is not the only journal with apparent bias against vitamin C, but it illustrates the general views in mainstream medicine. We also consider potential explanations for the widespread bias against vitamin C.
16
Namgung, C., YJ Rho, BH Jin, BS Lim, and BH Cho. "A Retrospective Clinical Study of Cervical Restorations: Longevity and Failure-Prognostic Variables." Operative Dentistry 38, no. 4 (June 1, 2013): 376–85. http://dx.doi.org/10.2341/11-416-c.
Full textAbstract:
SUMMARY The aim of this retrospective clinical study was to compare the longevity of cervical restorations between resin composite (RC) and glass ionomer (GI) and to investigate variables predictive of their outcome. The clinical performance of the two restorative materials in function was compared using the ratings of the modified United States Public Health Service (USPHS) criteria. A total of 479 cervical restorations were included in the study. Ninety-one already-replaced restorations were reviewed from dental records. The other 388 restorations still in function were evaluated according to the modified USPHS criteria by two investigators. Longevity and prognostic variables were analyzed with the Kaplan-Meier survival analysis and multivariate Cox proportional hazard model. The clinical performances of the two materials were evaluated according to the ratings of the USPHS criteria and compared using the Pearson chi-square test and Fisher exact test. The longevity was not significantly different between RC and GI (median survival time, 10.4 ± 0.7 and 11.5 ± 1.1 years, respectively). The main reasons for failure were loss of retention (82.2%) and secondary caries (17.8%). The longevity of cervical restoration was significantly influenced by tooth group and operator group (Wald test, p<0.05), while material, gender, presence or absence of systemic diseases, arch, and reason for treatment did not affect the longevity. Contrary to the longevity, the clinical performance of RC was superior to GI in the criteria of retention, marginal discoloration, and marginal adaptation, but similar in secondary caries, wear, and postoperative sensitivity.
17
Kong, Lingxin, Qingtao Zhao, Zhaohui Han, Wenfei Xue, Zhonghui Hu, Zhancong Niu, and Guochen Duan. "Prognostic significance of TG/HDL-C and non-HDL-C/HDL-C ratios in patients with non-small cell lung cancer: a retrospective study." Journal of International Medical Research 50, no. 8 (August 2022): 030006052211172. http://dx.doi.org/10.1177/03000605221117211.
Full textAbstract:
Objective Lung cancer is a malignancy with high a mortality rate that threatens human health. This study is aimed to explore the correlation among the triglyceride/high-density lipoprotein ratio (TG/HDL-C), non-high-density lipoprotein/high-density lipoprotein ratio (non-HDL-C/HDL-C) and survival of patients with non-small cell lung cancer (NSCLC) undergoing video-associated thoracic surgery (VATS). Methods This retrospective study analyzed 284 patients with NSCLC who underwent VATS at Hebei General Hospital, Shijiazhuang, China. The time-dependent receiver operating characteristic curve was used to determine the optimal cutoff value and evaluate the area under the curve. Kaplan–Meier and Cox regression analyses were performed to determine the prognostic effect. Results The median overall survival (OS) was 46 months. Patients with low TG/HDL-C and low non-HDL-C/HDL-C had a longer OS. The low non-HDL-C/HDL-C group showed a longer mean survival time (59.00 vs. 52.35 months). Multivariate analysis revealed that TG/HDL-C and non-HDL-C/HDL-C were significantly correlated with OS. Conclusions TG/HDL-C and non-HDL-C/HDL-C are associated with the prognosis of patients with NSCLC who received VATS. Preoperative serum TG/HDL-C and non-HDL-C/HDL-C may be effective independent prognostic factors for predicting the outcomes of patients with NSCLC.
18
Wilson, P. J. "(C.) Meier The political art of Greek tragedy. Tr. A. Webber. Oxford: Polity P, 1993. Pp. vii + 238. £39.50." Journal of Hellenic Studies 115 (November 1995): 187–88. http://dx.doi.org/10.2307/631664.
Full text
19
Wang, Shu-Ming, Jiung Hsiun Liu, Che-Yi Chou, Chiu-Ching Huang, Chuen-Ming Shih, and Walter Chen. "Mortality in Hepatitis C-Positive Patients Treated with Peritoneal Dialysis." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 28, no. 2 (March 2008): 183–87. http://dx.doi.org/10.1177/089686080802800215.
Full textAbstract:
Objective The published mortality data for patients with hepatitis C virus (HCV) infection and being treated with peritoneal dialysis (PD) are not available. The aim of this study was to determine the mortality of HCV patients undergoing PD. Methods We retrospectively reviewed 538 PD patients in our hospital from 1996 to 2005. Of these patients, 75 (13.9%) were anti-HCV positive at the beginning of PD. We used Kaplan–Meier analysis to compare mortality between patients with and patients without HCV infection. The association between HCV infection and mortality was analyzed using multivariate Cox regression with adjustment for age, gender, residual renal function, and cardiovascular disease. Results A total of 157 patients (39 HCV positive, 118 HCV negative) died during the 10-year follow-up period. The mortality rate (52%, 39/75) of HCV-positive patients was significantly higher than that of HCV-negative patients (25.5%, 118/463; p < 0.001). Cardiovascular mortality was 57.6% (68/118) among HCV-negative patients and 56.4% (22/39) among HCV-positive patients. Kaplan–Meier estimate showed that patients with HCV infection had higher mortality than those without ( p < 0.001, log-rank). The result of Cox regression suggested that chronic HCV infection, independent of diabetes, was associated with 10-year mortality. The adjusted hazard ratios (HRs) of HCV infection and diabetes for mortality were 2.195 (95% CI: 1.486 – 3.243, p < 0.001) and 2.242 (95% CI: 1.533 – 3.277, p < 0.001). Conclusion Our results show that the HCV-positive PD patients had a higher 10-year mortality rate than the HCV-negative PD patients. The association between HCV infection and mortality was independent of diabetes. Cardiovascular mortality, infection, and arrhythmia were the leading causes of death among the PD patients with HCV infection.
20
Hao, Bo, Xufeng Peng, Baochen Bi, Miaomei Yu, Chen Sang, and Zhen Chen. "Preoperative serum high-density lipoprotein cholesterol as a predictor of poor survival in patients with clear cell renal cell cancer." International Journal of Biological Markers 34, no. 2 (March 26, 2019): 168–75. http://dx.doi.org/10.1177/1724600819831404.
Full textAbstract:
Purpose: Numerous studies have suggested that dyslipidemia is closely related to various cancers and the high-density lipoprotein cholesterol (HDL-C) levels are associated with the outcome of cancer patients. However, the predictive value of HDL-C in patients with renal cell carcinoma remains unclear. Our study aims to explore the relationship between the levels of serum HDL-C and the prognosis of renal cell carcinoma. Methods: A total of 308 patients diagnosed with clear cell renal cell carcinoma (CCRCC) who received surgical treatment were retrospectively enrolled in our study. The necessary clinical data of each enrolled patient were collected and the Kaplan–Meier method and the Cox proportional hazards regression model were used to calculate the overall survival and cancer-specific survival. Results: Kaplan–Meier and univariate analysis showed that a lower preoperative serum HDL-C level was a risk factor of CCRCC patients. Multivariate analyses demonstrated that a higher serum HDL-C level was closely associated with better overall survival (hazard ratio = 0.32; 95% confidence interval (0.13, 0.78); P=0.013) and cancer-specific survival (hazard ratio =0.42; 95% confidence interval (0.15, 0.99); P=0.048). Conclusion: Our findings suggest that an increased serum level of HDL-C might predict better overall survival and cancer-specific survival in patients with CCRCC.
21
AMIN, J., M. G. LAW, J. MICALLEF, M. JAUNCEY, I. VAN BEEK, J. M. KALDOR, and G. J. DORE. "Potential biases in estimates of hepatitis C RNA clearance in newly acquired hepatitis C infection among a cohort of injecting drug users." Epidemiology and Infection 135, no. 1 (May 17, 2006): 144–50. http://dx.doi.org/10.1017/s0950268806006388.
Full textAbstract:
Estimates of hepatitis C virus (HCV) clearance following acute infection range from 14 to 46%. This wide range is likely to be due to the characteristics of the populations studied and analysis methods. This paper examines how differing definitions of clearance parameters affect estimates of viral clearance in a cohort of 85 injecting drug users with newly acquired HCV infection. Kaplan–Meier estimates of time to HCV clearance were determined using varying definitions of eligible cohort, viral clearance, date of infection and date of clearance. Based on which combinations of definitions were used, the number of subjects eligible for analysis ranged from 27 to 75, clearance rate ranged from 14 to 68% and time to achieving 25% clearance ranged from approximately 5 months to 14 months. Standardized definitions and methodologies are required to enable valid comparisons of rates of clearance across newly acquired HCV infection natural history studies.
22
Wegs, R. "German Women in the Nineteenth Century. John C. Fout (ed.) (New York: Holmes & Meier, 1984. xi plus 439 pp.)." Journal of Social History 20, no. 1 (September 1, 1986): 208–10. http://dx.doi.org/10.1353/jsh/20.1.208.
Full text
23
Henke, Lauren E., John D. Pfeifer, Thomas J. Baranski, Todd DeWees, and Perry W. Grigsby. "Long-term outcomes of follicular variant vs classic papillary thyroid carcinoma." Endocrine Connections 7, no. 12 (December 2018): 1226–35. http://dx.doi.org/10.1530/ec-18-0264.
Full textAbstract:
The majority of papillary thyroid carcinoma (PTC) cases comprise classic papillary (C-PTC) and follicular variant (FV-PTC) histologic sub-types. Historically, clinical equivalency was assumed, but recent data suggest C-PTC may have poorer outcomes. However, large single-institution series with long-term outcomes of C-PTC and FV-PTC, using modern pathologic criteria for FV-PTC, are needed. Our objective was to compare prevalence and impact of clinicopathologic factors, including BRAF mutation status, on long-term outcomes of C-PTC and FV-PTC. We hypothesized that patients with C-PTC would have higher risk disease features and worse survival outcomes. This retrospective study included 1293 patients treated at a single, US academic institution between 1943 and 2009 with mean follow-up of 8.6 years. All patients underwent either partial or total thyroidectomy and had invasive C-PTC or FV-PTC per modern pathology criteria. Primary study measurements included differences in recurrence-free survival (RFS), disease-specific survival (DSS) and associations with clinicopathologic factors including the BRAF mutation. Compared to FV-PTC, C-PTC was associated with multiple features of high-risk disease (P < 0.05) and significantly reduced RFS and DSS. Survival differences were consistent across univariate, multivariate and Kaplan–Meier analyses. BRAF mutations were more common in C-PTC (P = 0.002). However, on Kaplan–Meier analysis, mutational status did not significantly impact RFS or DSS for patients with either histologic sub-type. C-PTC therefore indicates higher-risk disease and predicts for significantly poorer long-term outcomes when compared to FV-PTC. The nature of this difference in outcome is not explained by traditional histopathologic findings or by the BRAF mutation.
24
Maryann Okafor, Ifeyinwa, Henshaw Uchechi Okoroiwu, and Christopher Ogar Ogar. "Diagnostic and prognostic value of c-MYC gene expression in hematological malignancies." African Health Sciences 23, no. 2 (July 13, 2023): 265–73. http://dx.doi.org/10.4314/ahs.v23i2.30.
Full textAbstract:
Introduction: c-MYC plays vital role in regulation of cell proliferation and has been associated with tumorigenesis. This studyis aimed at assessing diagnostic and prognostic value of plasma c-MYC expression to aid in early diagnosis and prognosis ofhematological malignancies.
Methods: Plasma c-MYC expression was determined by quantitative real time PCR using EVA Green chemistry and cluster ofdifferentiation markers performed via immunocytochemistry.
Result: Plasma c-MYC was higher in subject with hematological malignancies (8.8 ± 1.1) when compared with apparently healthy controls (4.5 ± 0.5). A screening cut-off c-MYC ratio value of 9.42 with sensitivity and specificity of 65.5% and 100% respectively were obtained using receiver operator characteristic curve analysis. Plasma c-MYC was found to have no prognostic value using Kaplan-Meier analysis.
Conclusion: Plasma c-MYC ratio showed promising screening/diagnostic value for hematological malignancies.
Keywords: c-MYC; c-MYC screening; prognosis with c-MYC; hematological malignancies; plasma c-MYC; c-MYC in malignancies;c-MYC expression.
25
Ott, Christine. "Franziska Meier, Besuch in der Hölle. Dantes Göttliche Komödie. Biographie eines Jahrtausendwerks, München, C. H. Beck 2021, 214 S." Deutsches Dante-Jahrbuch 97, no. 1 (October 24, 2022): 158–62. http://dx.doi.org/10.1515/dante-2022-0011.
Full text
26
Pan, Dikang, Julong Guo, Wenzhuo Meng, Jianming Guo, and Lianrui Guo. "Clinical features and surgical outcomes of childhood and adult Takayasu arteritis: A retrospective study." Vascular Investigation and Therapy 7, no. 1 (January 2024): 7–13. http://dx.doi.org/10.4103/vit.vit_19_24.
Full textAbstract:
Abstract: OBJECTIVE: Takayasu arteries (TAK) is a rare and unexplained inflammatory arterial disease that can occur in both children and adults. Our goal was to clarify the clinical features and surgical outcomes of aortitis in children and adults. METHODS: A retrospective cohort study was conducted on patients with TAK treated at tertiary care centers between 2012 and 2020. The American College of Rheumatology’s TAK criteria were used to select patients. Study results were reported using descriptive statistics and Kaplan–Meier methods. RESULTS: The cohort included 106 TAK patients with a median follow-up of 69 (interquartile range 80) months. Childhood TAK (c-TAK) differed from adult TAK (a-TAK) in terms of baseline: the predominant Nomo staging for c-TAK was Type IV (70.4), while the predominant staging for a-TAK was Type I (68.4%). Sixty-eight of them underwent surgical intervention, with a total of 85 vascular procedures (77 endoluminal procedures and 8 open procedures). c-TAK group had more endoluminal interventions (100%), while the a-TAK group had a higher proportion of open procedures (17.8%) than the c-TAK group, and the main complication in both groups was restenosis. Kaplan–Meier curves showed that c-TAK had a significantly higher rate of restenosis than a-TAK and had a significantly higher reintervention rate (logrank, P < 0.001). CONCLUSION: In conclusion, the main difference between c-TAK and a-TAK is that Nomo typing c-TAK is mainly Type IV, while a-TAK is mainly Type I. Furthermore, c-TAK has a higher rate of reintervention after surgical treatment than a-TAK, more attention should be paid to the postoperative follow-up of c-TAK patients, and further large sample studies are needed to confirm this.
27
Chen, Si-liang, Peng Hu, Zhi-peng Lin, and Jian-bo Zhao. "The Effect of Puncture Sites of Portal Vein in TIPS with ePTFE-Covered Stents on Postoperative Long-Term Clinical Efficacy." Gastroenterology Research and Practice 2019 (January 9, 2019): 1–11. http://dx.doi.org/10.1155/2019/2935498.
Full textAbstract:
Purpose. To evaluate the effect of puncture sites of the portal vein in transjugular intrahepatic portosystemic shunt (TIPS) on long-term clinical efficacy. Methods. A retrospective review was performed, including consecutive 171 patients who underwent TIPS with ePTFE-covered stents. All patients were divided into 3 groups according to the puncture site of the portal vein: intrahepatic bifurcation of the portal vein (group A, n=88), right branch of the portal vein (group B, n=48), and left branch of the portal vein (group C, n=35). The Kaplan-Meier analysis was performed to assess the effect of different puncture sites on primary patency, the incidence of hepatic encephalopathy (HE), and survival. Results. The primary restenosis rate was 29.8% (51/171). The total HE rate was 31.6% (54/171). The cumulative death rate was 19.3% (33/171). The Kaplan-Meier analysis showed that group C versus group A, group C versus group B, and group A versus group B were significantly different on the primary restenosis rate, respectively (χ2 = 11.49, P=0.001; χ2 = 4.54, P=0.033; and χ2 = 4.12, P=0.046), and group C is better than the other two groups. What is more, group C versus group A and group C versus group B were significantly different on the incidence of HE, respectively (χ2 = 8.07, P=0.004; χ2 = 9.44, P=0.002), and group C is better than the other two groups. There was no significant difference on survival. Conclusion. Choosing the left branch of the portal vein as the puncture site to create the shunt in TIPS with ePTFE-covered stents may decrease the incident of primary restenosis and HE significantly.
28
Agrelo, Ruben, Fernando Setien, Jesus Espada, Maria Jesus Artiga, Maria Rodriguez, Alberto Pérez-Rosado, Abel Sanchez-Aguilera, Mario F. Fraga, Miguel Angel Piris, and Manel Esteller. "Inactivation of the Lamin A/C Gene by CpG Island Promoter Hypermethylation in Hematologic Malignancies, and Its Association With Poor Survival in Nodal Diffuse Large B-Cell Lymphoma." Journal of Clinical Oncology 23, no. 17 (June 10, 2005): 3940–47. http://dx.doi.org/10.1200/jco.2005.11.650.
Full textAbstract:
Purpose Lamins support the nuclear envelope and provide anchorage sites for chromatin, but they are also involved in DNA synthesis, transcription, and apoptosis. Although the lack of expression of A-type lamins in lymphoma and leukemia has been reported, the mechanism was unknown. We investigated the possible role of CpG island hypermethylation in lamin A/C silencing and its prognostic relevance. Patients and Methods The promoter CpG island methylation status of the lamin A/C gene, encoding the A-type lamins, was analyzed by bisulfite genomic sequencing and methylation-specific polymerase chain reaction in human cancer cell lines (n = 74; from 17 tumor types), and primary leukemias (n = 60) and lymphomas (n = 80). Lamin A/C expression was determined by reverse-transcription polymerase chain reaction, Western blot, immunohistochemistry, and immunofluorescence. Results Lamin A/C promoter CpG island methylation was found in hematologic malignancies: seven (50%) of 14 leukemia- and five (42%) of 13 lymphoma cell lines. The presence of hypermethylation was associated with the loss of gene expression while a demethylating agent restored expression. In primary malignancies, lamin A/C hypermethylation was present in 18% (nine of 50) of acute lymphoblastic leukemias and 34% (14 of 41) of nodal diffuse large B-cell lymphomas. The presence of lamin A/C hypermethylation in nodal diffuse large B-cell lymphomas correlated strongly with a decrease in failure-free survival (Kaplan-Meier, P = .0001) and overall survival (Kaplan-Meier, P = .0005). Conclusion Epigenetic silencing of the lamin A/C gene by CpG island promoter hypermethylation is responsible for the loss of expression of A-type lamins in leukemias and lymphomas. The finding that lamin A/C hypermethylation is associated with poor outcome in diffuse large B-cell lymphomas suggests important clinical implications.
29
Crees, Zachary D., Caleb Shearrow, Leo Lin, Jennifer Girard, Kavin Arasi, Aayush Bhoraskar, Joseph Berei, et al. "EGFR/c-Met and mTOR signaling are predictors of survival in non-small cell lung cancer." Therapeutic Advances in Medical Oncology 12 (January 2020): 175883592095373. http://dx.doi.org/10.1177/1758835920953731.
Full textAbstract:
Background: EGFR/c-Met activation/amplification and co-expression, mTOR upregulation/activation, and Akt/Wnt signaling upregulation have been individually associated with more aggressive disease and characterized as potential prognostic markers for lung cancer patients. Methods: Tumors obtained from 109 participants with stage I–IV non-small cell lung cancer (NSCLC) were studied for EGFR/c-Met co-localization as well as for total and active forms of EGFR, c-Met, mTOR, S6K, beta-catenin, and Axin2. Slides were graded by two independent blinded pathologists using a validated scoring system. Protein expression profile correlations were assessed using Pearson correlation and Spearman’s rho. Prognosis was assessed using Kaplan–Meier analysis. Results: Protein expression profile analysis revealed significant correlations between EGFR/p-EGFR ( p = 0.0412) and p-mTOR/S6K ( p = 0.0044). Co-localization of p-EGFR/p-c-Met was associated with increased p-mTOR ( p = 0.0006), S6K ( p = 0.0018), and p-S6K ( p < 0.0001) expression. In contrast, active beta-catenin was not positively correlated with EGFR/c-Met nor any activated proteins. Axin2, a negative regulator of the Wnt pathway, was correlated with EGFR, p-EGFR, p-mTOR, p-S6K, EGFR/c-Met co-localization, and p-EGFR/p-c-Met co-localization (all p-values <0.03). Kaplan–Meier analysis revealed shorter median survival in participants with high expression of Axin2, total beta-catenin, total/p-S6K, total/p-mTOR, EGFR, and EGFR/c-Met co-localization compared with low expression. After controlling for stage of disease at diagnosis, subjects with late-stage disease demonstrated shorter median survival when exhibiting high co-expression of EGFR/c-Met (8.1 month versus 22.3 month, p = 0.050), mTOR (6.7 month versus 22.3 month, p = 0.002), and p-mTOR (8.1 month versus 25.4 month, p = 0.004) compared with low levels. Conclusions: These findings suggest that increased EGFR/c-Met signaling is correlated with upregulated mTOR/S6K signaling, which may in turn be associated with shorter median survival in late-stage NSCLC.
30
Schmeusser, Benjamin, Adil Ali, Dattatraya H. Patil, Eric Midenberg, Reza Nabavizadeh, Kenneth Ogan, and Viraj A. Master. "Creatinine to cystatin C ratio and mortality in renal cell carcinoma." Journal of Clinical Oncology 41, no. 6_suppl (February 20, 2023): 697. http://dx.doi.org/10.1200/jco.2023.41.6_suppl.697.
Full textAbstract:
697 Background: Creatinine and cystatin C are routinely used to assess renal function. Given creatinine originates from skeletal muscle and cystatin C is produced by nucleated cells, a creatinine to cystatin C ratio (Cr/Cys-C) may positively correlate with muscle mass. Low Cr/Cys-C has also been associated with decreased overall survival (OS) in cancer, including in a combined cohort of genitourinary malignancies. Furthermore, elevated cystatin c has been associated with shorter OS and recurrence free survival (RFS) in renal cell carcinoma (RCC). Cr/Cys-C may be a simple and affordable tool to assist with patient-specific risk stratification. We assess the ability of Cr/Cys-C to predict OS and RFS in patients with RCC. Methods: Retrospective review of a prospectively maintained database identified patients that underwent partial or radical nephrectomy for RCC from 2018-2021. Included patients had preoperative creatinine and cystatin C and 1+ year of follow up. Cr/Cys-C associations with patient/tumor characteristics were determined by generalized chi-square or Fisher’s exact tests for categorical variables and Wilcoxon rank-sum test for continuous variables. Cr/Cys-C ability to predict OS and RFS was analyzed with Kaplan-Meier method and Cox hazards models. Statistical tests were two-sided with type I error set at 0.05. Results: 219 patients were identified. Median age was 64, with most being male (67%). 62% and 29% of patients were white and black, respectively. Median eGFR was 72mL/min/1.73m2. Median (IQR) Cr/Cys-C was 1 (0.8-1.2). 55% were stage T3-T4, with 12% N1 and 16% M1 at time of surgery. 72% had clear cell histology. Low Cr/Cys-C was significantly associated with older age, males, Eastern Cooperative Oncology Group score ≥ 1, radical nephrectomy, T3-T4 stage, and metastasis. Kaplan-Meier curves showed low Cr/Cys-C association with decreased OS (p=0.0003) and RFS (p=0.0094). Cox regression analysis revealed lower Cr/Cys-C as independent predictor of decreased OS (binary HR=3.66, 95% CI 1.2-11.3, p=0.02; continuous HR=0.05, 95% 0.0-0.8, p=0.03) and RFS (binary HR=4.8, 95% CI 1.6-14.6, p=0.006; continuous HR=0.02, 95% 0.0-0.3, p=0.006;Table). Conclusions: Lower Cr/Cys-C may be associated with decreased OS and RFS in patients with RCC. [Table: see text]
31
Shah, Rahman, Saifullah Khan Khalil, Umar Aleem, Falak Naz, Naimat Ullah, and Najeeb Ullah. "Association of Interleukin-28b- Rs8099917 with Response to Treatment with Interferon Α-2b & Ribavirin in C. Hepatitis C pts." Pakistan Journal of Medical and Health Sciences 16, no. 3 (March 26, 2022): 28–29. http://dx.doi.org/10.53350/pjmhs2216328.
Full textAbstract:
Aim: To reassess the high specificity of alkaline phosphatase as a serum tumor marker in patients with osteosarcoma Study type: Retrospective cohort study Study place and duration: Department of Orthopedics, DHQ Hospital Gujranwala from January 2013 to June 2021 Methods: The medical record of 140 osteosarcoma patients were reviewed retrospectively, who received treatment for osteosarcoma during January 2015 and June 2021. According to clinical factors at diagnosis, the difference in prevalence of increased ALP was assessed using Fisher`s extract test and χ2 test. In the groups with normal and high level of serum ALP at presentation, the disease-free survival (DFS) and overall survival (OS) were compared using The Kaplan–Meier estimate. At presentation the prognostic ability of increased ALP was examined using Cox regression analyses. For determination of therapeutic steps and survival related changes in levels of ALP during therapy and survival related response of ALP to therapy, Linear Mixed model (fixed model) was used. Results: Sensitivity, specificity , Positive predictive value, negative predictive value, PLR, NLR and DOR of ALP in Metastatic osteosarcoma at 15 months follow up was 55.4%, 80.3%, 62.1%, 74.2%, 3.14, 0.864 and 5.241 respectively. Similarly, Sensitivity, specificity , Positive predictive value, negative predictive value, PLR, NLR and DOR of ALP in Metastatic osteosarcoma at 3 years follow up was 56.4%, 92.5%, 83.1%, 70.1%, 6.321, 0.632 and 8.543 respectively. Conclusion: ALP has been found to be a very important tumor marker having high specificity in patients with osteosarcoma. MeSH words: Osteosarcoma, Tumor, Biomarker, Alkaline Phosphatase, Metastasis, Sensitivity, Specificity
32
Choque Aliaga, Osman. "Reseña de Heinrich Meier, Nietzsches Vermächtnis: Ecce homo und Der Antichrist. Zwei Bücher über Natur und Politik. München: C. H. Beck, 2019." Revista de humanidades (Santiago. En línea), no. 49 (January 29, 2024): 485–89. http://dx.doi.org/10.53382/issn.2452-445x.790.
Full text
33
Fasano, Serena, Luciana Pierro, Ilenia Pantano, Michele Iudici, and Gabriele Valentini. "Longterm Hydroxychloroquine Therapy and Low-dose Aspirin May Have an Additive Effectiveness in the Primary Prevention of Cardiovascular Events in Patients with Systemic Lupus Erythematosus." Journal of Rheumatology 44, no. 7 (May 15, 2017): 1032–38. http://dx.doi.org/10.3899/jrheum.161351.
Full textAbstract:
Objective.Systemic lupus erythematosus (SLE) is associated with an increased risk of cardiovascular disease (CVD). Thromboprophylaxis with low-dose aspirin (ASA) and hydroxychloroquine (HCQ) seems promising in SLE. We investigated the effects of HCQ cumulative dosages (c-HCQ) and the possible synergistic efficacy of ASA and HCQ in preventing a first CV event (CVE) in patients with SLE.Methods.Patients consecutively admitted to our center who, at admission, satisfied the 1997 American College of Rheumatology and/or 2012 Systemic Lupus Collaborating Clinics classification criteria for SLE, and had not experienced any CVE, were enrolled. The occurrence of a thrombotic event, use of ASA, and c-HCQ were recorded. Kaplan-Meier analysis was performed to determine the c-HCQ associated with a lower incidence of CVE. Cox regression analysis served to identify factors associated with a first CVE.Results.For the study, 189 patients with SLE were enrolled and monitored for 13 years (median). Ten CVE occurred during followup. At Kaplan-Meier analysis, the CVE-free rate was higher in ASA-treated patients administered a c-HCQ > 600 g (standard HCQ dose for at least 5 yrs) than in patients receiving ASA alone, or with a c-HCQ dose < 600 g (log-rank test chi-square = 4.01, p = 0.04). Multivariate analysis showed that antimalarials plus ASA protected against thrombosis (HR 0.041 and HR 0.047, respectively), while antiphospholipid antibodies (HR 17.965) and hypertension (HR 18.054) increased the risk of a first CVE.Conclusion.Our results suggest that prolonged use of HCQ plus ASA is thromboprotective in SLE and provides additional evidence for its continued use in patients with SLE.
34
Huang, Qiao, and Chong Tian. "Visualizing Time-Varying Effect in Survival Analysis: 5 Complementary Plots to Kaplan-Meier Curve." Oxidative Medicine and Cellular Longevity 2022 (March 29, 2022): 1–12. http://dx.doi.org/10.1155/2022/3934901.
Full textAbstract:
Background. Kaplan-Meier (KM) curve has been widely used in the field of oxidative medicine and cellular longevity. However, time-varying effect might be presented in KM curve and cannot be intuitively observed. Complementary plots might promote clear insights in time-varying effect from KM curve. Methods. Three KM curves were identified from published randomized control trials: (a) curves diverged immediately; (b) intersected curves with statistical significance; and (c) intersected curves without statistical significance. We reconstructed individual patient data, and plotted 5 complementary plots (difference in survival probability and risk difference, difference in restricted mean survival time, landmark analyses, and hazard ratio over time), along with KM curve. Results. Entanglement and intersection of two KM curves would make the 5 complementary plots to fluctuate over time intuitively. Absolute effects were presented in the 3 plots of difference in survival probability, risk, and restricted mean survival time. Changed P values from landmark analyses were used to inspect conditional treatment effect; the turning points could be identified for further landmark analysis. When proportional hazard assumption was not met, estimated hazard ratio from traditional Cox regression was not appropriate, and time-varying hazard ratios could be presented instead of an average and single value. Conclusions. The 5 complementary plots with KM curve give a broad and straightforward picture of potential time-varying effect. They will provide clear insight in treatment effect and assist clinicians to make decision comprehensively.
35
Du, Zhenguang, Qianru He, Xiaodan Xing, Qin Zhang, Qianqian Duan, Tingting Sun, and Chuang Qi. "VEGFR-C mutation serves as a potential negative predictor for immunotherapy in metastatic melanoma." Journal of Clinical Oncology 40, no. 16_suppl (June 1, 2022): e21593-e21593. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.e21593.
Full textAbstract:
e21593 Background: Immune checkpoint blockade has shown significant promise as an anticancer treatment and anti–CTLA-4 treatment prolongs overall survival in patients with melanoma. Vascular endothelial growth factor-C (VEGF-C), a member of the VEGF gene family, has been characterised as a prime mediator of lymphangiogenesis and angiogenic growth factors that promote the growth and metastasis of neoplasms. Previous studies provided evidence that VEGF-C correlated with poorer survival in melanoma. We aimed to determine the association of VEGF-C mutations with melanoma survival to immune checkpoint inhibitors (ICI). Methods: Data from Allen study (n = 110, anti- CTLA-4 therapy) was obtained and analyzed. Meanwhile, we extracted skin cutaneous melanoma (SKCM) RNA data from The Cancer Genome Atlas (TCGA). In survival analysis, Kaplan-Meier curves were compared by log-rank test, and the hazard ratio (HR) was determined through a multivariable Cox regression model. Using the Cell-type Identification by Estimating Relative Subsets of RNA Transcripts (CIBERSORT) algorithm, the relative proportions of 22 types of infiltrating immune cells were determined in TCGA cohort. Results: In Allen cohort, the frequency of VEGFR-C mutation was 5.45% (6 in 110). Meanwhile, the frequency of VEGFR-C mutation in TCGA cohort was 7.37% (33 in 448). VEGFR-C-mutant (VEGFR-C-mut) group showed a poorer progression-free survival (PFS) (HR, 2.34; 95%CI, 1.01 to 5.4, p = 0.041) and overall survival (OS) (HR, 2.84, 95%CI, 1.22 to 6.62, p = 0.012) than the VEGFR-C-wild (VEGFR-C-wt) group, based on results of the log-rank test and Kaplan-Meier analysis. Moreover, COX proportional hazards model analysis showed VEGFR-C mutation was associated with poorer PFS (HR, 2.54; 95%CI, 1.04-6.25, p = 0.0042;) and OS (HR, 3.25; 95%CI, 1.30-8.12, p = 0.0117) compared with VEGFR-C-wt. In addition, we identified that the levels of naive B cells and resting CD4+ memory T cells were more abundant in VEGFR-C-mut group according to CIBERSORT algorithm. Conclusions: In our study, the frequency of VEGFR-C mutation in melanoma was investigated in Allen and TCGA cohorts, which might provide useful information to guide precision medicine. VEGFR-C mutation may serve as a potential negative predictor of response to anti-CTL4 treatment in melanoma via higher levels of naive B cells and resting CD4+ memory T cells.
36
Chou, Che-Yi, I.-Kuan Wang, Jiung-Hsiun Liu, Hsin-Hung Lin, Shu-Ming Wang, and Chiu-Ching Huang. "Comparing Survival between Peritoneal Dialysis and Hemodialysis Treatment in Esrd Patients with Chronic Hepatitis C Infection." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 30, no. 1 (January 2010): 86–90. http://dx.doi.org/10.1177/089686081003000101.
Full textAbstract:
Objective End-stage renal disease (ESRD) patients with hepatitis C virus (HCV) infection are associated with an increasing mortality risk on hemodialysis (HD) and peritoneal dialysis (PD). The aim of this study was to compare patient survival between HCV-positive patients undergoing PD versus HD. Methods We reviewed 78 PD and 78 HD patients with chronic hepatitis C infection in China Medical University Hospital from 1996 to 2006. The HD patients were selected using the propensity score matching method. Kaplan–Meier analysis with log-rank test was used to compare patient survival between patients treated with PD and those treated with HD. Possible prognostic factors were analyzed using multivariate Cox proportional hazard regression with adjustments for age, sex, and propensity score. Results Mortality rate was 50% (39/78) for PD and 41% (32/78) for HD (chi-square test p = 0.26). Diabetes, hypertension, and cardiovascular disease were present in 43.6%, 25.6%, and 14.1% of patients, respectively. Kaplan–Meier estimate and univariate Cox regression with adjustments for age and propensity score showed that HCV patients treated with PD had a similar survival to those treated with HD ( p = 0.381 and p = 0.363). In forward stepwise Cox regression, positivity for hepatitis B virus surface antigen ( p < 0.001), diabetes ( p = 0.009), and serum albumin ( p = 0.032) were independently associated with higher mortality. Conclusion Patient survival is not different between ESRD patients with chronic hepatitis C treated with PD and those treated with HD. In ESRD patients positive for HCV, being positive for hepatitis B virus is an important prognostic factor.
37
Sclafani, Francesco, David Gonzalez, David Cunningham, Sanna Hullki Wilson, Clare Peckitt, Josep Tabernero, Bengt Glimelius, et al. "Relationship of RAS and TP53 predictive value for cetuximab (C) benefit: Results of the EXPERT-C trial." Journal of Clinical Oncology 32, no. 3_suppl (January 20, 2014): 447. http://dx.doi.org/10.1200/jco.2014.32.3_suppl.447.
Full textAbstract:
447 Background: We previously reported that TP53 status may predict C benefit in patients with locally advanced rectal cancer treated with neoadjuvant chemotherapy and chemoradiotherapy (CRT) and this effect appeared to be independent of KRAS. Recent studies indicate that NRAS mutations and KRAS mutations beyond exons 2-3 may also preclude benefit from anti-EGFRs. We analyzed whether the predictive value of TP53 in EXPERT-C was independent of RAS. Methods: 164 patients received 4 cycles of CAPOX followed by CRT, surgery, and 4 cycles of adjuvant CAPOX (n=81) or the same regimen plus C (CAPOX-C, n=83) and were analyzed for KRAS (exons 2-3) and NRAS (exon 3). TP53 mutations (exons 4-9) were screened for by CE-SSCA. KRAS (exon 4) and NRAS (exons 2 and 4) mutations were screened for by bi-directional Sanger sequencing. Progression-free survival (PFS) and overall survival (OS) were estimated with Kaplan-Meier methods and log-rank analysis was used to compare the treatment arms. The interaction between treatment and TP53 was adjusted for prognostic variables and RAS in a multivariate model. Results: 75/144 (52%) eligible patients had a TP53 mutation. 81/86 patients with known KRAS (exons 2-3) and NRAS (exon 3) wild-type (WT) status were analyzed for the remaining RAS mutations. Of these, 11 (13%) had tumours with mutation in KRAS exon 4 (11%) or NRAS exons 2/4 (2%). Overall, 75/144 (52%) patients were RAS WT (CAPOX, n=39; CAPOX-C, n=36). After a median follow-up of 65 months, no difference in PFS (HR 1.21, p=0.59) and OS (HR 0.97, p=0.94) was observed between TP53 mutant patients treated with CAPOX or CAPOX-C. In TP53 WT patients, the addition of C was associated with a statistically significant improvement in PFS (HR 0.23, p=0.02) and OS (HR 0.16, p=0.02). A significant interaction between TP53 status and C effect was found (PFS, p=0.029; OS, p=0.036). In multivariate analyses, this interaction remained significant even after adjusting for RAS status (PFS, p=0.026; OS, p=0.033). Conclusions: In EXPERT-C, the value of TP53 as predictive biomarker for C benefit was independent of RAS. The value of monoallelic vs. biallelic TP53 inactivation will be presented at the meeting.
38
Fang, Shenying, Yuling Wang, Dawen Sui, Huey Liu, Merrick I. Ross, Jeffrey E. Gershenwald, Janice N. Cormier, et al. "C-Reactive Protein As a Marker of Melanoma Progression." Journal of Clinical Oncology 33, no. 12 (April 20, 2015): 1389–96. http://dx.doi.org/10.1200/jco.2014.58.0209.
Full textAbstract:
Purpose To investigate the association between blood levels of C-reactive protein (CRP) in patients with melanoma and overall survival (OS), melanoma-specific survival (MSS), and disease-free survival. Patients and Methods Two independent sets of plasma samples from a total of 1,144 patients with melanoma (587 initial and 557 confirmatory) were available for CRP determination. Kaplan-Meier method and Cox regression were used to evaluate the relationship between CRP and clinical outcome. Among 115 patients who underwent sequential blood draws, we evaluated the relationship between change in disease status and change in CRP using nonparametric tests. Results Elevated CRP level was associated with poorer OS and MSS in the initial, confirmatory, and combined data sets (combined data set: OS hazard ratio, 1.44 per unit increase of logarithmic CRP; 95% CI, 1.30 to 1.59; P < .001; MSS hazard ratio, 1.51 per unit increase of logarithmic CRP; 95% CI, 1.36 to 1.68; P < .001). These findings persisted after multivariable adjustment. As compared with CRP < 10 mg/L, CRP ≥ 10 mg/L conferred poorer OS in patients with any-stage, stage I/II, or stage III/IV disease and poorer disease-free survival in those with stage I/II disease. In patients who underwent sequential evaluation of CRP, an association was identified between an increase in CRP and melanoma disease progression. Conclusion CRP is an independent prognostic marker in patients with melanoma. CRP measurement should be considered for incorporation into prospective studies of outcome in patients with melanoma and clinical trials of systemic therapies for those with melanoma.
39
Saadat, Mostafa, Samane Safaie, and Iraj Saadat. "Genetic Polymorphism of C-262T Catalase and Susceptibility to Schizophrenia." Open Access Macedonian Journal of Medical Sciences 2, no. 1 (March 15, 2014): 74–77. http://dx.doi.org/10.3889/oamjms.2014.013.
Full textAbstract:
Background: Catalase (CAT, OMIM: 115500) plays an integral role in the primary defence against oxidative stress. The T allele of the C-262T CAT polymorphism (rs1001179) is associated with lower activity of CAT. Here we investigated whether polymorphism of C-266T CAT was associated with susceptibility to schizophrenia.Methods: The present study was performed on 363 (267 males, 96 females) in-patients with schizophrenia diagnosis, and a total of 363 (266 males, 97 females) healthy controls. The C-262T CAT genotypes were determined using RFLP-PCR method.Results: Although the association between genotypes and susceptibility was not significant in both genders, there was significant interaction between gender and the TT genotype (P=0.035). The Log-rank test and the Kaplan-Meier survival analysis were used to evaluate the influence of C-262T genotypes on age at diagnosis (AAD) of schizophrenia. Mean AAD of the CC and CT+TT genotypes in males was 22.8 and 24.9 years, respectively. The difference was significant (c2=4.26, P=0.039). Difference of mean AAD of the CC (26.7 years) and CT+TT (27.3 years) genotypes among females was not significant (c2=0.02, P=0.896).Conclusion: Different associations between gender groups might be at least in part interpreted by the effect of gender on the association between C-262T polymorphism and CAT gene expression.
40
Talbot, Ross. "Agriculture and the State: Market Processes and Bureaucracy. By E. C. PasourJr,. New York: Holmes & Meier, 1990. 258p. $39.95 cloth, $19.95 paper." American Political Science Review 85, no. 1 (March 1991): 300–302. http://dx.doi.org/10.2307/1962928.
Full text
41
Roncin, Jean-Yves, and Françoise Launay. "Comment on “The EUV dayglow at high spectral resolution” by M. D. Morrison, C. W. Bowers, P. D. Feldman, and R. R. Meier." Journal of Geophysical Research: Space Physics 96, A2 (February 1, 1991): 1881. http://dx.doi.org/10.1029/90ja02449.
Full text
42
Zhang, Huimin, Ya Zhang, Xiangxiang Zhou, Xiang Sun, Yang Han, Xinting Hu, Xiaoya Yun, and Xin Wang. "Prognostic Role of C-Reactive Protein, C-Reactive Protein Kinetics and C-Reactive Protein/ Albumin Ratio in Newly Diagnosed B-Cell Chronic Lymphoproliferative Diseases." Blood 136, Supplement 1 (November 5, 2020): 15–16. http://dx.doi.org/10.1182/blood-2020-138704.
Full textAbstract:
Introduction: C-reactive protein (CRP), the most commonly used clinical indicator of inflammation, plays an important role in disease diagnosis and efficacy evaluation. Recent studies identified elevated CRP level and CRP kinetics, dynamic change of CRP level throughout treatment, were associated with decreased clinical outcome in some malignancies. Because of increased catabolism and the reduce of hepatic synthesis, albumin is oppositely associated with inflammatory. CRP/ albumin ratio (CAR) is a novel and superior prognostic factor involving inflammatory and nutritional factors in various cancers. However, the prognostic role of CRP, CRP kinetics and CRA in B-cell chronic lymphoproliferative diseases (B-CLPD) were not well characterized yet. Our study focused on the prognostic role of CRP, CRP kinetics and CRA in newly diagnosed B-CLPD. Methods: In total, 243 newly diagnosed B-CLPD patients from January 2012 to December 2019 at the Shandong provincial hospital in China were analyzed for overall survival (OS) and disease-free survival (DFS), depending on CRP, CRP kinetics and CRA. OS and DFS were determined by Kaplan-Meier curves and log-rank test. Cox proportional analysis was performed to examine the prognostic significance of clinicopathological variables in multivariate analyses. Results: The five-year OS of patients with elevated pretreatment CRP level (94.3% vs. 56.7%, p<0.001) (Figure 1a), elevated post-treatment CRP level (81.7% vs. 39.4%, p<0.001) (Figure 1c), continuously elevated CRP level during the whole treatment process (80.0% vs. 47.1%, p<0.001) (Figure 1e) and elevated pretreatment CRA level (93.1% vs. 61.9%, p<0.001) (Figure 1g) were shorter than normal patients, respectively. Compared to normal patients, the five-year DFS of patients with elevated pretreatment CRP level (88.0% vs. 33.9%, p<0.001) (Figure 1b), elevated post-treatment CRP level (56.4% vs.35.7%, p=0.020) (Figure 1d), ever-elevated CRP level (62.9% vs. 35.3%, p<0.001) (Figure 1f), continuously elevated CRP level during the whole treatment process (80.2% vs. 35.3%, p<0.001) (Figure 1f) and elevated pretreatment CRA level (87.3% vs. 42.8%, p<0.001) (Figure 1h) were shorter, respectively. Multivariate analyses identified that elevated pretreatment CRP level (HR: 5.110, p=0.001) (Table 1), elevated post-treatment CRP level (HR: 5.826, p=0.006) (Table 2), continuously elevated CRP level (HR: 6.461, p<0.001) (Table 3) and elevated pretreatment CAR (HR: 3.768, p=0.008) (Table 4) had association with worse OS. Likewise, elevated pretreatment CRP level (HR: 3.767, p=0.001) (Table 1), post-treatment CRP level (HR: 2.384, p=0.043) (Table 2), ever-elevated CRP level (HR: 2.425, p=0.027) (Table 3), continuously elevated CRP level (HR: 4.748, p<0.001) (Table 3) and elevated pretreatment CAR level (HR: 2.824, p=0.007) (Table 4) were in independent significance with worse DFS. Conclusions : We demonstrate that CRP level, CRP kinetics and CAR could be potential prognostic indicators with independent significance in patients with B-CLPD. CRP and CAR make an implementation for prognostic evaluation more easily and effectively in B-CLPD patients. Disclosures No relevant conflicts of interest to declare.
43
Murakami, Shinsuke, Noritoshi Nagaya, Takefumi Itoh, Takafumi Fujii, Takashi Iwase, Kaoru Hamada, Hiroshi Kimura, and Kenji Kangawa. "C-type natriuretic peptide attenuates bleomycin-induced pulmonary fibrosis in mice." American Journal of Physiology-Lung Cellular and Molecular Physiology 287, no. 6 (December 2004): L1172—L1177. http://dx.doi.org/10.1152/ajplung.00087.2004.
Full textAbstract:
C-type natriuretic peptide (CNP) has been shown to play an important role in the regulation of vascular tone and remodeling. However, the physiological role of CNP in the lung remains unknown. Accordingly, we investigated whether CNP infusion attenuates bleomycin (BLM)-induced pulmonary fibrosis in mice. After intratracheal injection of BLM or saline, mice were randomized to receive continuous infusion of CNP or vehicle for 14 days. CNP infusion significantly reduced the total number of cells and the numbers of macrophages, neutrophils, and lymphocytes in bronchoalveolar lavage fluid. Interestingly, CNP markedly reduced bronchoalveolar lavage fluid IL-1β levels. Immunohistochemical analysis demonstrated that CNP significantly inhibited infiltration of macrophages into the alveolar and interstitial regions. CNP infusion significantly attenuated BLM-induced pulmonary fibrosis, as indicated by significant decreases in Ashcroft score and lung hydroxyproline content. CNP markedly decreased the number of Ki-67-positive cells in fibrotic lesions of the lung, suggesting antiproliferative effects of CNP on pulmonary fibrosis. Kaplan-Meier survival curves demonstrated that BLM mice treated with CNP had a significantly higher survival rate than those given vehicle. These results suggest that continuous infusion of CNP attenuates BLM-induced pulmonary fibrosis and improves survival in BLM mice, at least in part by inhibition of pulmonary inflammation and cell proliferation.
44
REINOSO-PEREIRA, Gleicy Luz, Denise Cerqueira PARANAGUÁ-VEZOZZO, Daniel F. MAZO, João Italo Dias FRANÇA, Suzane Kioko ONO, and Flair José CARRILHO. "HIGH VALUES OF LIVER STIFFNESS PLAY AN IMPORTANT ROLE IN STRATIFYING THE RISK OF HEPATOCELLULAR CARCINOMA IN CIRRHOTIC HEPATITIS C PATIENTS." Arquivos de Gastroenterologia 59, no. 2 (June 2022): 204–11. http://dx.doi.org/10.1590/s0004-2803.202202000-38.
Full textAbstract:
ABSTRACT Background: Evaluate the role of liver stiffness measurement (LSM) by transient elastography (TE) as a risk factor for hepatocellular carcinoma (HCC) occurrence in a prospective cohort of Brazilian hepatitis C virus (HCV) patients with cirrhosis. Methods: A cohort of 99 consecutive HCV patients was included between 2011 and 2016 with baseline LSM ≥12 kilopascals (kPa). Baseline variables were evaluated and HCC occurrence was documented. Kaplan-Meier methods with a log-rank test and the use of cox univariate and multivariate analysis assessed the association between variables and clinical results. Results: The mean age was 57.8±10.6 years. In a follow-up over a mean of 3.3 years, 20 (20.2%) patients developed HCC. In univariate logistic regression analysis, variables associated with HCC occurrence were: lower platelet count (P=0.0446), higher serum alpha-fetoprotein (P=0.0041) and bilirubin (P=0.0008) values, higher Model for End-Stage Liver Disease (MELD) score (P=0.0068) and higher LSM (P=0.0354). LSM evaluated by TE was independently associated with HCC development, and the best cut-off value for higher HCC risk was >21.1 kPa (HR: 5.548; 95%CI: 1.244-24.766; P=0.025). Conclusion: A high value of liver stiffness relates substantially to an increased risk for HCC occurrence in Brazilian patients with cirrhosis due to HCV.
45
Toby, B. H., M. M. Eddy, C. A. Fyfe, G. T. Kokotailo, H. Strobl, and D. E. Cox. "A high-resolution NMR and synchrotron x-ray powder diffraction study of zeolite ZSM-11." Journal of Materials Research 3, no. 3 (June 1988): 563–69. http://dx.doi.org/10.1557/jmr.1988.0563.
Full textAbstract:
High-resolution nuclear magnetic resonance (NMR) spectra and synchrotron x-ray powder diffraction data have been obtained from a well-crystallized highly dealuminated sample of the zeolite ZSM-11. The Rietveld profile technique has been applied to the synchrotron data to give the first detailed refinement of the idealized structure derived ten years ago by distance least-squares modeling methods [G. T. Kokotailo, P. Chu, S. L. Lawton, and W. M. Meier, Nature 275, 119 (1978)], which involves 54 variable atomic positional parameters. The structure is tetragonal (a = 20.065 Å, c = 13.408 Å at 25 °C) and consistent with the previously reported tetragonal space group I \overline 4 m2, but the NMR spectra indicate local deviations from this symmetry that disappear at 100 °C.
46
Lima, Mauro Sérgio Cruz Souza, Jonas Pederassi, Carlos Augusto dos Santos Sousa, João Mendes Frazão Sobrinho, and Joara de Sousa Andrade. "Influence of temperature on larval development of Pleurodema diplolister (amphibia, anura, leptodactylidae)." Cuadernos de Educación y Desarrollo 15, no. 6 (July 24, 2023): 5416–32. http://dx.doi.org/10.55905/cuadv15n6-030.
Full textAbstract:
The population fluctuations of amphibians were correlated with climatic changes, and among the aspects listed the global temperature change was one of the highlights. We submitted tadpoles of Pleurodema diplolister to aquatic thermal variations to establish the thermal limit that implies the direct influence of temperature on larval development, as could occur in the global temperature change. Natural lentic environments were monitored in a way to acquire the mean temperature of the water in an annual (tolerant) average (31°C) and in the reproduction (optimal) period (27°C) of the frogs. In lab conditions the tadpoles’ development were tested in four different temperatures: 20°C, 27°C, 31°C, and 40°C, corresponding to minimal, optimal, tolerant, and maximum temperatures, respectively. The survival time was established by the Kaplan-Meier method. The data were tested by the Chi-square test to establish the adherence of the results. The success rate calculated for 20°C temperature was 3.69%, at 27°C it was 62.33%, at 31°C it was 68% and at 40°C it was 1.35%. This demonstrates that there is an optimal temperature of larval development with a tolerance zone around it, which indicates that an increase in global temperature, immediately, will not stop the reproduction of this species.
47
Schmidt, Marcus, Karolina Edlund, Jan G. Hengstler, Anne-Sophie Heimes, Katrin Almstedt, Antje Lebrecht, Slavomir Krajnak, et al. "Prognostic Impact of Immunoglobulin Kappa C (IGKC) in Early Breast Cancer." Cancers 13, no. 14 (July 20, 2021): 3626. http://dx.doi.org/10.3390/cancers13143626.
Full textAbstract:
We studied the prognostic impact of tumor immunoglobulin kappa C (IGKC) mRNA expression as a marker of the humoral immune system in the FinHer trial patient population, where 1010 patients with early breast cancer were randomly allocated to either docetaxel-containing or vinorelbine-containing adjuvant chemotherapy. HER2-positive patients were additionally allocated to either trastuzumab or no trastuzumab. Hormone receptor-positive patients received tamoxifen. IGKC was evaluated in 909 tumors using quantitative real-time polymerase chain reaction, and the influence on distant disease-free survival (DDFS) was examined using univariable and multivariable Cox regression and Kaplan–Meier estimates. Interactions were analyzed using Cox regression. IGKC expression, included as continuous variable, was independently associated with DDFS in a multivariable analysis also including age, molecular subtype, grade, and pT and pN stage (HR 0.930, 95% CI 0.870–0.995, p = 0.034). An independent association with DDFS was also found in a subset analysis of triple-negative breast cancers (TNBC) (HR 0.843, 95% CI 0.724–0.983, p = 0.029), but not in luminal (HR 0.957, 95% CI 0.867–1.056, p = 0.383) or HER2-positive (HR 0.933, 95% CI 0.826–1.055, p = 0.271) cancers. No significant interaction between IGKC and chemotherapy or trastuzumab administration was detected (Pinteraction = 0.855 and 0.684, respectively). These results show that humoral immunity beneficially influences the DDFS of patients with early TNBC.
48
Jiang, Q., Z. Wang, S. Zhang, X. Liu, and B. Fu. "Performance of Bonded Lithium Disilicate Partial-coverage Crowns in the Restoration of Endodontically Treated Posterior Teeth: An Up to Seven-Year Retrospective Study." Operative Dentistry, July 8, 2024. http://dx.doi.org/10.2341/23-107-c.
Full textAbstract:
SUMMARY Objectives: To evaluate the clinical performance of adhesively bonded lithium disilicate glass-ceramic (LDG) partial-coverage crowns in restoring posterior endodontically treated teeth (ETT). Methods and Materials: A total of 121 morphologically compromised posterior ETT were restored with LDG partial-coverage crowns between October 2015 and January 2018. The restorations were fabricated in the laboratory or at the chairside. Two adhesive systems and resin cements were used to cement the restorations. Tooth and restoration survival rates were calculated. The restorations were evaluated clinically using the modified United States Public Health Service (USPHS) criteria for an observation period of 5-7 years. The Cox proportional hazards model was used to estimate relative failure risks such as tooth type, resin cements, gender, and sleep bruxism. The standard chi-squared test was used to compare the survival of different tooth types for significant differences (α=0.05). In addition, survival probability was calculated using the Kaplan–Meier algorithm. Results: Among seven failed cases, one was a tooth fracture, and six were restoration fractures. According to the Kaplan–Meier analysis, the estimated survival rate of the teeth was 99% for seven years, while the estimated survival rate of the restorations was 94.8% for 5 years and 92.8% for 7 years. Tooth type and resin cements did not influence restoration survival rates (p>0.05), while sleep bruxism and male patients might increase the risk of failure (p<0.05). Conclusions: The indirect adhesively bonded LDG partial-coverage crowns of posterior ETT exhibited favorable clinical outcomes. Ceramic fracture was the most common failure pattern.
49
Shiba, Nobuyuki, Tomohiro Tada, Mika Matsuki, Yutaka Kagaya, and Hiroaki Shimokawa. "Abstract 4167: Prognostic Importance of Nutritional Status in Patients with Chronic Heart Failure." Circulation 114, suppl_18 (October 31, 2006). http://dx.doi.org/10.1161/circ.114.suppl_18.ii_899-c.
Full textAbstract:
Background: Nutritional abnormalities are common among patients with chronic heart failure (CHF). However, little is known regarding clinical implication to evaluate the nutritional status in CHF patients. In this study, we examined the prognostic impact of nutrition-related factors, including serum albumin level (ALB), total lymphocyte count (TLC), and body mass index (BMI) in patients with CHF. Methods: We prospectively enrolled 280 stable patients with stage-C/D CHF since February 2000. Kaplan-Meier analyses and multivariate Cox regression analyses were performed to evaluate the association between the mortality and the nutrition-related factors mentioned above. Covariables used in the multivariate models were ALB, TLC, BMI, hemoglobin concentration, left ventricular ejection fraction, etiology of CHF, serum creatinine level, and age at the entry. Results: The mean age of the study population was 61.2±14.9 years and the mean follow-up period was 2.4±1.5 years. Kaplan-Meier analyses showed that the incidences of all-cause mortality were significantly higher in patients with lower ALB, lower TLC, or lower BMI as compared those without the nutritional abnormalities (Figure ). Multivariate analyses revealed that higher TLC was an independent significant predictor of freedom from cardiac-cause death (HR 0.9993, p=0.016) and higher ALB was significantly associated with increased survival (HR 0.563, p=0.03). Conclusions: The evaluation of nutritional status may be a powerful and cost-effective tool in predicting the mortality of patients with CHF. Further research is necessary to evaluate the importance of nutritional improvement in such patients.
50
Favetti, M., T. Schroeder, AF Montagner, RR Moraes, T. Pereira-Cenci, and MS Cenci. "NaOCl Application after Acid Etching and Retention of Cervical Restorations: A 3-Year Randomized Clinical Trial." Operative Dentistry, May 18, 2022. http://dx.doi.org/10.2341/20-166-c.
Full textAbstract:
SUMMARY This study evaluated the retention of composite resin restorations in noncarious cervical lesions (NCCLs) performed with or without pretreatment with 10% NaOCl solution (deproteinization). A randomized, controlled, split-mouth, doubleblinded trial was carried out. Thirty patients with at least two NCCLs were included in the study. The NCCLs were randomly allocated into two treatment groups: control (acid etching with 37% phosphoric acid + placebo solution + Adper Single Bond 2/3M Oral Care + Filtek Z350/3M Oral Care) or experimental group (acid etching with 37% phosphoric acid + 10% NaOCl solution + Adper Single Bond 2 + Filtek Z350). A calibrated examiner evaluated the restorations at baseline (1 week) and recalls (6, 12, 24, and 36 months) using the FDI criteria. The primary outcome evaluated was retention of the restorations. Data were analyzed by the Kaplan-Meier method and the log-rank test (α=0.05). After 3 years, 64 restorations were evaluated in 23 patients. The annual failure rate was 9% for the control group and 17.8% for the experimental group (deproteinization technique). Considering the failures and their distribution among the characteristics of the patients and NCCLs, no statistically significant differences were observed for the control and experimental treatment groups (p=0.077) or the number of teeth in the mouth (p=0.320). Restorations in the mandible (p=0.039) and premolars (p=0.013) showed significantly lower clinical survival rates. The deproteinization pretreatment with a 10% NaOCl solution did not promote additional retention of restorations in NCCLs. (clinicaltrials. gov: NCT03086720)