Dissertations / Theses on the topic 'Medicinal substances'
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Belo, Cristóvão Ramiro. "Bétele (Piper Betle Linn): Análise de Metabolitos e acção sobre a Acetilcolinesterase." Dissertação, Faculdade de Farmácia da Universidade do Porto, 2009. http://hdl.handle.net/10216/20777.
Full textMSc in Quality Control
Piper betle L., conhecida como bétele, é uma espécie que se desenvolve largamente nos países do Sudeste Asiático, onde as suas folhas são económica e medicinalmente importantes. Para determinar o maior número possível de compostos voláteis e semivoláteis, as folhas foram sujeitas as diferentes processos de extracção, nomeadamente headspace - microextracção em fase sólida (HS-SPME), hidrodestilação e extracção por Soxhlet, e posteriormente analisadas por GC/MS, o que permitiu identificar 50 compostos, distribuídos por várias classes químicas, 23 dos quais foram descritos pela primeira vez. As diferentes técnicas permitiram a extracção de compostos distintos, sendo a HS-SPME aquela com que se obteve o perfil mais completo e com que se determinou maior teor de compostos. Dentro deste processo os melhores resultados foram obtidos utilizando a fibra revestida com divinilbenzeno/polidimetilsiloxano (DVB/PDMS). Considerando que a espécie é vulgarmente mascada, o seu extracto aquoso também foi analisado, tendo sido caracterizados apenas sete compostos, sendo o eugenol o composto principal. A composição em ácidos orgânicos deste extracto foi determinada por HPLC/UV e os ácidos oxálico, aconítico, cítrico, pirúvico, málico, chiquímico, acético e fumárico foram descritos pela primeira vez. O extracto aquoso também revelou capacidade para inibir a acetilcolinesterase de modo dependente da concentração.
Piper betle L., popularly known as “Paan”, is a species widely growing in South East Asia, where its leaves are economically and medicinally important. In order to screen the highest possible number of volatile and semi-volatile components, the leaves were subjected to headspace solid-phase microextraction (HS-SPME), hydrodistillation and Soxhlet extraction, prior to their analysis by GC/MS, which allowed the identification of 50 compounds, distributed by several chemical classes, 23 of them described for the first time. The different techniques lead to distinct compounds' extraction, with HS-SPME extracting highest amounts and providing the most complete profile. Within this procedure, best results were obtaine using Divinylbenzene/Polydimethylsiloxane (DVB/PDMS) fibre. Considering the use of the species as masticator, an aqueous extract was also analysed, in which only seven compounds were characterize, being eugenol the main one. The organic acids composition of this extract was determine by HPLC/UV and oxalic, aconitic, citric, pyruvic, malic, shikimic, acetic and fumaric acids are reported for the first time in this species. The aqueous extract also displayed AChE inhibitory capacity, in a concentration-dependent way.
Belo, Cristóvão Ramiro. "Bétele (Piper Betle Linn): Análise de Metabolitos e acção sobre a Acetilcolinesterase." Master's thesis, Faculdade de Farmácia da Universidade do Porto, 2009. http://hdl.handle.net/10216/20777.
Full textMSc in Quality Control
Piper betle L., conhecida como bétele, é uma espécie que se desenvolve largamente nos países do Sudeste Asiático, onde as suas folhas são económica e medicinalmente importantes. Para determinar o maior número possível de compostos voláteis e semivoláteis, as folhas foram sujeitas as diferentes processos de extracção, nomeadamente headspace - microextracção em fase sólida (HS-SPME), hidrodestilação e extracção por Soxhlet, e posteriormente analisadas por GC/MS, o que permitiu identificar 50 compostos, distribuídos por várias classes químicas, 23 dos quais foram descritos pela primeira vez. As diferentes técnicas permitiram a extracção de compostos distintos, sendo a HS-SPME aquela com que se obteve o perfil mais completo e com que se determinou maior teor de compostos. Dentro deste processo os melhores resultados foram obtidos utilizando a fibra revestida com divinilbenzeno/polidimetilsiloxano (DVB/PDMS). Considerando que a espécie é vulgarmente mascada, o seu extracto aquoso também foi analisado, tendo sido caracterizados apenas sete compostos, sendo o eugenol o composto principal. A composição em ácidos orgânicos deste extracto foi determinada por HPLC/UV e os ácidos oxálico, aconítico, cítrico, pirúvico, málico, chiquímico, acético e fumárico foram descritos pela primeira vez. O extracto aquoso também revelou capacidade para inibir a acetilcolinesterase de modo dependente da concentração.
Piper betle L., popularly known as “Paan”, is a species widely growing in South East Asia, where its leaves are economically and medicinally important. In order to screen the highest possible number of volatile and semi-volatile components, the leaves were subjected to headspace solid-phase microextraction (HS-SPME), hydrodistillation and Soxhlet extraction, prior to their analysis by GC/MS, which allowed the identification of 50 compounds, distributed by several chemical classes, 23 of them described for the first time. The different techniques lead to distinct compounds' extraction, with HS-SPME extracting highest amounts and providing the most complete profile. Within this procedure, best results were obtaine using Divinylbenzene/Polydimethylsiloxane (DVB/PDMS) fibre. Considering the use of the species as masticator, an aqueous extract was also analysed, in which only seven compounds were characterize, being eugenol the main one. The organic acids composition of this extract was determine by HPLC/UV and oxalic, aconitic, citric, pyruvic, malic, shikimic, acetic and fumaric acids are reported for the first time in this species. The aqueous extract also displayed AChE inhibitory capacity, in a concentration-dependent way.
Ananieva, V. V., S. О. Petrov, and D. S. Goloborodko. "Search of new excipients in technology of farmaceutical drugs." Thesis, Національний технічний університет "Харківський політехнічний інститут", 2018. http://repository.kpi.kharkov.ua/handle/KhPI-Press/45931.
Full textVarvaštian, Samvel. "Nanomedicinos teisinis reglamentavimas: ES ir JAV požiūris." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2013. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2013~D_20130205_094831-00731.
Full textThe master thesis researches the current regulation of nanomedicine in the EU and the US. Until now, this topic has not yet been researched in Lithuania. In the first part of the thesis nanomedicine and the problem of nanomedicine-related definitions are introduced to the reader. The second part reveals the basis of the regulation of nanomedicine in the EU, and the third part – in the US. Furthermore, considering the achieved results, the perspective of the future regulation of nanomedicine is assessed. The thesis extensively analyses the legal acts of the chosen subjects of international law and specific legal literature (documents of various institutions, works of law scholars) as well as some scientific-technical literature (reports and researches of various institutions and organizations, scientists’ researches).
Davies, Rachel A. "Structure-Activity Relationship Studies of Synthetic Cathinones and Related Agents." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/5953.
Full textViscardi, Ariel. "Avaliação da atividade antiproliferativa de extratos hidroalcoólicos de plantas em linhagens celulares humanas de câncer de mama, fígado e próstata." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/82/82131/tde-29082018-140818/.
Full textCancer is one of the most common diseases overworld. Studying the therapeutics of it is important to understand the biological mechanisms and targets behind this disease. Although conventional treatments show a good outcome against some types of cancer, they also currently cause undesired responses, such as molecular damage, neoplastic cell resistance and strong side effects, increasing recurrence of neoplasms, metastasis formation, and patient mortality. Therefore, the search for new alternatives is a challenge for Modern Science to improve or replace conventional treatments. In view of their antiproliferative effects medicinal plants have become the focus of many cancer studies as an alternative. The aim of the present study was to evaluate the cytotoxic and antiproliferative effect of 59 plant extracts in human cancer cell lines as breast cancer (MDA-MB-231 and MCF7), prostate cancer (PC-3 and DU 145) and liver cancer (HepG2). Initially, the extracts were screened in two different dilutions 100x and 1000x by MTT to analyze the cellular viability and cytotoxicity effects of them. To 59 extracts analyzed, 35 were effective against at least one of the tested lineages. The next step involved studying those pre-selective extracts through response curves to quantify the selectivity of these extracts for each cell lineage tested. For this stage, 31 extracts were selected. In breast cancer, for MDA-MB-231, nine extracts were selective and for MCF7 were six extracts. In prostate cancer, for PC-3, fifteen extracts were selective and for DU 145 were sixteen extracts. For liver cancer (HepG2) only seven extracts were selective. Comparing all the cancer lineages we can see a greater sensitivity of prostate cancer lineages compared to breast cancer and liver cancer in response of these tested extracts. Of all the results presented, silk cotton (Calotropis procera), chamomile (Matricaria chamomilla), winter\'s bark (Drimys winteri), bitter melon (Momordica charantia L.), corn silk (Zea mays), graviola (Annona muricata), purple trumpet tree (Tabebuia sp.), malva - folhas (Malva sylvestris) e unha de gato (Uncaria tomentosa) silk cotton (Calotropis procera), chamomile (Matricaria chamomilla), graviola (Annona muricata) and mallow-leaves (Malva sylvestris) were the most effective extracts reaching different cell types and present high selectivity indices. With the accomplishment of this work we can conclude that the natural extracts of plants presented antiproliferative activity in cancer lines and their phytochemicals can be used to study new herbal medicines. The next step, then, is to understand the molecular mechanisms where they act.
Alarcon, Gallegos Ligia Rocio. "Ethnobotany of the southern Basque country (Euskadi), Spain : the use of medicinal and foods plants and selection of species for further development of functional foods which increase perceived energy levels : identification and characterization of the effects of food substances which increase perceived energy levels." Thesis, University College London (University of London), 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.522821.
Full textPersson, Ingrid. "Plant-Derived Substances and Cardiovascular Diseases : Effects of Flavonoids, Terpenes and Sterols on Angiotensin-Converting Enzyme and Nitric Oxide." Doctoral thesis, Linköpings universitet, Hälsouniversitetet, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-45338.
Full text2009
Houël, Emeline. "ETUDE DE SUBSTANCES BIOACTIVES ISSUES DE LA FLORE AMAZONIENNE Analyse de préparations phytothérapeutiques à base de Quassia amara L. (Simaroubaceae) et de Psidium acutangulum DC. (Myrtaceae) utilisées en Guyane française pour une indication antipaludique. Identification et analyse métabolomique d'huiles essentielles à activité antifongique." Phd thesis, Université des Antilles-Guyane, 2011. http://tel.archives-ouvertes.fr/tel-00718910.
Full textDavies, Christopher S. "The role of oxygen-dependent substances in exercise." Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/4273/.
Full textTroxler, Joyce. "What is Substance Use Disorder." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/etsu-works/6514.
Full textGainche, Maël. "Etudes phytochimiques et activités anti-inflammatoires de plantes médicinales auvergnates." Thesis, Université Clermont Auvergne (2017-2020), 2020. http://www.theses.fr/2020CLFAC001.
Full textThe research work of this thesis, included in the Plantinauv project,aims to enhance the botanical heritage of Auvergne by identifying plants of medicinal and nutritional interest exhibiting anti-inflammatory activities, and to allow their merchandising (or that of their isolated bioactive agents) in the form of nutraceutical, cosmetic and / or veterinary products. This project involves a consortium of academic(UMR, UNH) and industrial partners from the cluster Vegepolys Valley (Greentech, Domes Pharma and Altophyto).Among the plants of the Auvergne flora, sixteen were selected to assess the anti-inflammatory potential of their extracts (chemical and biological tests). Six of them, present on different regulatory lists (nutraceutical, cosmetic, veterinary), have been the subject of phytochemical studies.The chemo-and bio-guided fractionation of L. sylvaticaand D. fullonumextracts allowed the isolation of new secondary metabolites. Four new phenanthrenes with promising anti-proliferative activities on cancer cells were isolated from L. sylvatica. The phytochemical profiles of the four other plants (P. erecta, T. angustifolia, H. stoechas, K arvensis) were also determined. Finally, the standardization of the different plant extracts was studied in order to develop new marketable ingredients
Thomas, Gethin Owain. "Smart screens for thyroid disrupting substances in the environment." Thesis, Cardiff University, 2006. http://orca.cf.ac.uk/54105/.
Full textNisbet, Lorna A. "The analysis and detection of new psychoactive substances in biological matrices." Thesis, University of Glasgow, 2015. http://theses.gla.ac.uk/7213/.
Full textCherrie, J. W. "Reconstructing the past : estimating exposure to hazardous substances in occupational epidemiology." Thesis, University of Aberdeen, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338329.
Full textEdwards, Vicki. "Adolescent substance use and bullying : is there a link?" Thesis, University of Leicester, 2002. http://hdl.handle.net/2381/7643.
Full textAshton, Victoria. "Comorbid trauma and substance misuse : enhancing conceptual knowledge." Thesis, University of Warwick, 2003. http://wrap.warwick.ac.uk/4508/.
Full textHartley, Christopher Bernard. "Substances hazardous to health : the nature of the expertise associated with competent risk assessment." Thesis, Aston University, 1997. http://publications.aston.ac.uk/15318/.
Full textWallis, L. A. E. "Diffusion of new psychoactive substances : understanding population motives, harms and intervention needs." Thesis, Liverpool John Moores University, 2018. http://researchonline.ljmu.ac.uk/9180/.
Full textJabar, Ardil. "Substance abuse programs that reduce violence in a youth population : systematic review." Master's thesis, University of Cape Town, 2013. http://hdl.handle.net/11427/11001.
Full textThe systematic review undertaken for this MPH dissertation examines the existing evidence for youth violence interventions involving substance abuse intervention programs. Part A is the review protocol which outlines the background and process of the review. Search strategies combined related terms for youth, violence and a broad combination of terms for the intervention. Inclusion criteria were broad enough to include a wide range of study designs, given the large heterogeneity of outcomes and the paucity of randomised controlled trials (RCTs). Abstracts were screened by two reviewers, as were selected full texts articles. These were evaluated using the EPHPP questionnaire, a quantitative study assessment tool to identify methodological issues.
Alabbas, Alhumaidi B. "GLYCOSAMINOGLYCAN LYASES IN THE PREPARATION OF OLIGOSACCHARIDES." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5279.
Full textPienkowski, Stefan, and Abbey Mann. "Providers’ Perspective on Treating Patients for Substance Use Disorder in Northeast Tennessee." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/etsu-works/6440.
Full textWahab, M. I. "Medicine and recreational substance use in pregnancy : epidemiology and the health beliefs of expectant mothers." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1456309/.
Full textCrick, Emma. "Experiences of participants of support groups, in relation to substance misuse and shame." Thesis, University of Hull, 2009. http://hydra.hull.ac.uk/resources/hull:2677.
Full textKalebka, R. R. "A survey of attitudes towards patient substance abuse/addiction in the emergency center." Master's thesis, University of Cape Town, 2012. http://hdl.handle.net/11427/11934.
Full textIncludes bibliograpical references.
Hospitals across South Africa are inundated with patients suffering from conditions associated with substance abuse. It is inevitable that contact with health services be made through an emergency centre (EC) at some point. This study aims to assess the exposure and attitudes of emergency physicians to substance abuse and addiction in major South African academic ECs. A prospective survey based on the Substance Abuse Attitude Survey (SAAS) was conducted in a convenience sample of eighty five emergency physician registrars and junior consultants in Cape Town, Gauteng, Limpopo and KwaZulu Natal. Respondents were targeted during academic meetings and by post.
Mohd, Fauzi Fazlin Binti. "In silico target prediction : applications to traditional medicine and novel psychoactive substances and the extension to biological space." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708743.
Full textHarenza, Jo Lynne. "Genetic Dissection of Quantitative Trait Loci for Substances of Abuse." VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/3190.
Full textMitaine-Offer, Anne-Claire. "Recherche de substances naturelles antipaludiques : etude chimique et biologique de cinq plantes d'amerique du sud (doctorat : pharmacognosie)." Reims, 1998. http://www.theses.fr/1998REIMP211.
Full textPerkonigg, Axel, Roselind Lieb, and Hans-Ulrich Wittchen. "Substance Use, Abuse and Dependence in Germany." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2012. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-99907.
Full textŠimkūnaitė, Agnė. "Psichoaktyviųjų medžiagų vartojimo tarp I – III kurso VU Medicinos fakulteto studentų paplitimas ir jį įtakojantys veiksniai." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2010. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2008~D_20101125_185252-68082.
Full textBackground. According to the scientific material of the last decade major part of health problems in Europe and all around the World are due to psychical and behavioural disorders. It has become an economical burden for the countries whereas psychical health services have become one of the major concerns. The latest psychological and social researches and studies suggest that the most vulnerable part of the society is youth. So, the goal of this study is to determine the prevalence of using psychoactive substances amongst first-third year students of Vilnius University Medicine Faculty and factors influencing it. Methods. Anonymous inquiry was performed in the year 2007. A self-administered questionnaire of The European School Survey Project on Alcohol and Other Drugs (ESPAD), which was modified and applied for the exploratory crop, was completed by 556 first-third year students of Vilnius University Medicine Faculty. The data was analysed using the statistical programe SPSS 15.0. Results. In total 18,3% of Vilnius University Medicine Faculty first-third year students reported smoking. The majority of them smoked every day. Boys students reported significantly greater smoking then girls students (p < 0,05). 77,3% of students reported using alcohol. Most often used alcoholic drinks were wine and beer. 68,7% of students used coffee whereas half of them used energetic drinks as well. Caffeine containing tablets were not popular amongst the students. 12,1% of those who studied... [to full text]
Cotereau, Béatrice. "La cicatrisation et l'application aux médicaments spécialisés à base de plantes et substances dérivées à propriétés cicatrisantes." Paris 5, 1988. http://www.theses.fr/1988PA05P028.
Full textMontgomery, Robert A., Tifani R. Fletcher, Andrea D. Clements, and Beth A. Bailey. "Religious Commitment Predicts Substance Use in Pregnant Women." Digital Commons @ East Tennessee State University, 2013. https://dc.etsu.edu/etsu-works/7261.
Full textAbreu, Ilka Nacif de. "Isolamento e produção de substancias de interesse farmacologico de Hypericum brasiliense Choisy." [s.n.], 2002. http://repositorio.unicamp.br/jspui/handle/REPOSIP/315484.
Full textTese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia
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Resumo: O crescente interesse no estudo de espécies do gênero Hypericum, em decorrência das publicações sobre os efeitos farmacológicos de extratos de H. perforatum, fez com que surgissem nos últimos anos estudos fitoquímicos e farmacológicos com H. brasiliense, demonstrando que a espécie apresenta grande potencial farmacológico. Neste trabalho, a partir de análises fitoquímicas em raízes de H. brasiliense foram isoladas as substâncias acilfloroglucinol, xantona e ácido betulínico, que tiveram suas estruturas elucidadas através de técnicas de RMN de H1 e C13, EM, UV e IV. Tais substâncias, juntamente com quercetina e rutina, também identificadas nos extratos, foram quantificadas em diferentes partes das plantas (apical, mediana superior, mediana inferior e raiz), quando em diferentes estádios de desenvolvimento (vegetativo, florescimento e frutificação) e em plantas com 2 e 3 meses, após serem submetidas a estresse hídrico (hipoxia e déficit hídrico) e térmico (10, 30, 17 e 36°C sob baixa e alta intensidade luminosa). A variabilidade genética do material utilizado nos experimentos foi avaliada através da técnica de isozimas, utilizando dez sistemas enzimáticos. Também foi estudado o potencial morfogenético in vitro de gemas apicais provenientes de plantas em estádio de desenvolvimento juvenil e adulto. Completando o trabalho foi realizada a análise da composição do óleo essencial através de CG-EM, por co-injeção com hidrocarbonetos de cadeia longa e comparação do índice de Kovats, dos compostos identificados, com os da literatura. A maior produção de compostos fenólicos ocorreu quando as plantas encontravam-se em florescimento, mas o maior acúmulo de ácido betulínico ocorreu quando as plantas encontravam-se em frutificação. Verificou-se produção de metabólitos secundários em resposta às condições de estresse, havendo correlação inversa entre crescimento e a produção dos compostos analisados. Em condição de déficit hídrico houveram as maiores produções de compostos fenólicos totais e ácido betulínico, sendo que em temperatura noturna de 10°C e 36°C constante houve maior produção de compostos fenólicos totais. A produção de acilfloroglucinol intensificou-se sob déficit hídrico, mas a de xantona foi maior sob hipoxia. Também foi constatada produção de antocianinas em condições de elevada peroxidação lipídica. As análises isozimáticas revelaram que as enzimas eram monomórficas, com apenas 0,09% de variação de alelos, demonstrando que apesar da espécie não ser domesticada, praticamente não há variabilidade genética entre os indivíduos da população em estudo. As gemas, apicais provenientes de plantas juvenis proporcionaram desenvolvimento in vitro com dominância apical, sendo que as provenientes de plantas adultas, proporcionaram florescimento in vitro. Do óleo essencial, 20 compostos foram identificados (94,17% da composição total do óleo), sendo os principais representantes: ß-cariofileno, aromadendreno, a-humuleno, ledeno, ?-cadineno, ledol, óxido de cariofileno, epóxido de humuleno II, cubenol e a-muurolol
Abstract: The increasing interest in studying representatives of the genus Hypericum, mainly because the recent publications on the pharmacological effects of extracts of H. perforatum, has motivated Brazilian scientists to investigate the species H. brasiliense, demonstrating its phytochemical and pharmacological potential. In the present work, the substances acylfloroglucinol, xanthone and betulinic acid were isolated from rots of H. brasiliense and their structure identified by NMR-H1 and C13, mass spectrometry, UV and infrared spectra. These substances, together quercetin and rutin also identified in the extracts, were quantified in different parts of H. brasiliense plants (in the shoot - apical, middle and bottom of the canopy - and roots) , in different developmental stage (vegetative, flowering, frutification) and in plants (2 and 3 months old) subjected to water stress (hipoxy and deficit) and different temperature regimes (10, 30, 17 and 36°C under high and low light intensity). The genetic variability was also studied in the plant material used in the above experiments, using eleven isozyme systems. In addition, the in vitro morphogenetics potential of apical meristems in two developmental stages, named here juvenile and adult stages. Other phytochemical characterization was carried out with the essential oil fraction extracted from the whole plant which was analysed and identified by gas chromatography-mass spectrometry and co-injection with long chain hydrocarbons, and the data obtained compared with the Kovats index for substances already described in the literature. From the experiments of isolation and identification of substances with pharmacological potential, the phenolic substances (acylfloroglucinol, quercetina, rutin and xanthone) accumulated during the flowering. Betulinic acid was found in higher amounts at the fructification. It was observed increase of secondary metabolites in response to drought and a negative relationship between plant growth and the content of these compounds. Phenolic compounds and betulinic acid accumulated more under water stress. In addition, constant night temperatures (10°C and 36°C) induced the largest accumulation of phenolic compounds. There was an increase of acylfloroglucinol with water stress and xanthones increased under hipoxy. The stress was characterized by the increase in anthocyanins and membrane lipid peroxidation. Regarding the genetic variability, isozyme analyses showed that the enzymes used in the study were monomorphy showing only 0,09% allelic variation. This results means that despite of H. brasiliense is not domesticated genetic variability is almost absent in the population used in the present study. The apical meristem from juvenile plants proportionated plants displaying apical dominance while those from adults resulted in plants flowering in vitro. Twenty substances were isolated and identified in the analysis of the essential oil from of H. brasiliense amounting for 94.17% of the total fraction. The main substances were ß-caryophyllene, aromadendrene, a-humulene, ledene, ?-cadinene, ledol, caryophyllene oxide, humulen epoxide II, cubenol e a-muurolol
Doutorado
Doutor em Biologia Vegetal
Miller, Stacy. "Change and recovery from substance misuse : Native American perspectives /." [Missoula, Mont.] : The University of Montana, 2008. http://etd.lib.umt.edu/theses/available/etd-03262009-133921/unrestricted/Miller_umt_0136D_10012.pdf.
Full textTitle from author supplied metadata. Description based on contents viewed on June 15, 2009. ETD number: etd-03262009-133921. Author supplied keywords: Native Americans ; Medicine Wheel ; Alcohol misuse ; Substance Misuse ; Transtheoretical Model of Change. Includes bibliographical references.
Roessel, Emily Lynn. "EXERCISE TRAINING AS ADJUNCT THERAPY FOR SUBSTANCE USE DISORDER." Scholarly Commons, 2020. https://scholarlycommons.pacific.edu/uop_etds/3681.
Full textSoldatenko, Alexandra. "Les implications juridiques des nanotechnologies." Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAA033.
Full textWhile a significant number of products containing nanomaterials is already in widespread use, we have little understanding of risks and benefits they can bring to the society in the long term. The objective of this PhD thesis is to answer the following question: which regulatory framework can ensure a high level of protection against real or suspected risks of nanotechnologies while promoting competitiveness and innovation ? Although the European Union and the United States have attempted to find nuanced solutions according to the needs, capacities and challenges, which are proper to each sector concerned and their respective legal traditions, the emerging regulatory framework for nanotechnologies is characterised by a high degree of fragmentation
O'Hara, Connor P. "Inhibition of Cancer Stem Cells by Glycosaminoglycan Mimetics." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/5989.
Full textRoberts, Lisa Jeanne. "Utilities for mental health outcomes among individuals with co-occurring substance use disorders and schizophrenia : a feasibility study /." Thesis, Connect to this title online; UW restricted, 2001. http://hdl.handle.net/1773/9146.
Full textAshter, Suzanne. "Weight changes : the meaning of food and eating behaviours amongst women in recovery from substance addiction." Thesis, London Metropolitan University, 2014. http://repository.londonmet.ac.uk/713/.
Full textShi, Zhi Qing. "Compartmental distribution of amino acids and middle molecular substances in normal and galactosamine induced fulminant hepatic failure rats." Thesis, McGill University, 1985. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=70360.
Full textA generalized elevation of amino acid concentrations is demonstrated in the systemic blood plasma, portal plasma, CSF, cerebrum, liver, kidney and skeletal muscle tissues in GalN-FHF. The skeletal muscle is found to constitute the greatest source of accumulated amino acids in FHF. The other tissues also contribute to the increased amino acids in the body as a whole. The increase in aromatic amino acids (AAA) tyrosine, phenylalanine and free and total tryptophan were the most striking among all the amino acids, including branched chain amino acids (BCAA), in all the tissues studied. The molar ratio of BCAA/AAA was found significantly reduced in all the tissues studied. $ gamma$-amino butyric acid was found significantly increased in the cerebrum and the brain stem. Most of the increased tryptophan in plasma, and almost 100% of the increased tryptophan in the brain were in the free form (non-protein bound). The increase in tyrosine concentration in plasma was closely correlated with tyrosine in the brain. Hemoperfusion using collodion coated activated charcoal (CAC) significantly reduced a number of aromatic amino acids in the plasma. This was followed by a significant reduction of the AAA in CSF, but not in the brain, of GalN-FHF rats. Hemoperfusion using tyrosinase immobilized within artificial cells selectively reduced tyrosine in the plasma but did not influence the tyrosine level in the brain. Hemoperfusion procedures resulted in a high plasma clearance for the aromatic amino acids. The results also suggested the loss of the blood brain barrier for amino acids across the capillaries. However, transport mechanisms between brain cells themselves and interstitial fluid seems to be maintained.
The buildup of middle molecular metabolites (MW 500-2,000) was demonstrated as the elevation of middle molecule peak 7g in the plasma and brain extract samples from GalN-FHF rats using serial liquid chromatography. CAC hemoperfusion significantly reduced the levels of 7g fraction in both plasma and brain extract samples. The fraction of subpeak 7g was found to contain peptidic substances. SDS-polyacrylamide gel electrophoresis further revealed the peptide nature of some of the middle molecule substances. The estimated molecular weight of these peptides was in the range of 1,300 and 1,400. Radioimmunoassay study indicated the increase of substance P (MW 1,345) in the plasma of GalN-FHF rats.
Park, Crystal L., Kevin S. Masters, John M. Salsman, Amy Wachholtz, Andrea D. Clements, Elena Salmoirago-Blotcher, Kelly Trevio, and Danielle M. Wischenka. "Advancing Our Understanding of Religion and Spirituality in the Context of Behavioral Medicine." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etsu-works/7201.
Full textLi, Jonas. "The potential of Schistosoma-derived substances for use as basis for novel anti-haemostatic therapeutics: : A systematic review." Thesis, Örebro universitet, Institutionen för medicinska vetenskaper, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-91526.
Full textAhlqvist, Hillforth Caroline. "The health effects of per- and polyfluoroalkyl substances (PFAS) : A literature-based risk assessment for subpopulations in Uppsala." Thesis, Örebro universitet, Institutionen för hälsovetenskaper, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-83394.
Full textGromelsky, Ljungcrantz Emily. "A descriptive study on self-reported non- and pharmacological substances used for treatment by symptomatic knee osteoarthritis patients." Thesis, Örebro universitet, Institutionen för medicinska vetenskaper, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-65275.
Full textPetersson, Anna. "Characteristics and Consequences of Use of Anabolic Androgenic Steroids in Poly Substance Abuse." Doctoral thesis, Uppsala universitet, Rättsmedicin, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9261.
Full textPolaha, J. P., and Robert P. Public Health Pack. "Substance Use Disorder in Appalachia: Challenges for Cultural Competency." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etsu-works/1341.
Full textEriksson, Sara. "Laboratory adjustment to the new regulation on classification, labeling and packaging of substances and mixtures." Thesis, Uppsala universitet, Institutionen för kvinnors och barns hälsa, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-204661.
Full textWright, Blanche O. "Associations Between Substance Abuse and Mental Illness Among Sexual Minority Adults." ScholarWorks, 2018. https://scholarworks.waldenu.edu/dissertations/5438.
Full textPack, Robert P., and Samantha A. Mathis. "Substance Use Disorder in Central Appalachia: Challenges for Cultural Competency." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etsu-works/1344.
Full textFamojuro, Oluwaseun, Olushola Fapo, and Shimin 3284473 Zheng. "ASSOCIATION OF SUBSTANCE USE AND OBESITY AMONG ADULTS IN UNITED STATES(FINDINGS FROM BRFSS 2016)." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/asrf/2018/schedule/187.
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