Relevant bibliographies by topics / Medicinal profile

Academic literature on the topic 'Medicinal profile'

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Published: 18 May 2024

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Journal articles on the topic "Medicinal profile"

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Wright, Stephen W. "Career Profile: Medicinal Chemist." Journal of Chemical Education 84, no. 10 (October 2007): 1579. http://dx.doi.org/10.1021/ed084p1579.

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RAKHIMOVA, Sh Kh. "PROTEIN PROFILE OF MEDICINAL PLANTS." Journal of Research in Pharmacy 27_special_issue_7, no. 27_special_issue_7 (2023): 76. http://dx.doi.org/10.29228/jrp.633.

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Zheplinska, Marija, Mikhailo Mushtruk, Volodymyr Vasyliv, Anatolii Kuts, Natalia Slobodyanyuk, Larysa Bal-Prylypko, Mykola Nikolaenko, Olena Kokhan, Yuriy Reznichenko, and Oksana Salavor. "The micronutrient profile of medicinal plant extracts." Potravinarstvo Slovak Journal of Food Sciences 15 (June 28, 2021): 528–35. http://dx.doi.org/10.5219/1553.

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Medicinal plants contain biologically active substances that have a physiological effect on the human body. In the territory of Ukraine, 15 of the most important medicinal plants grow from a medical point of view, among which are Melissa officinalis L and Сalendula officinalis. Micronutrients are necessary for the body in small quantities, not being a source of energy, they take part in their assimilation, as well as in the regulation of various functions and the implementation of the processes of growth and development of the human body. The study aims to establish the micronutrient profile of extracts and infusions from medicinal raw materials – Сalendula officinalis and Melissa officinalis. The established micronutrient profile includes data on the content of such macro- and microelements as calcium, potassium, sodium, iron, zinc, and copper in extracts and infusions from Melissa officinalis L officinalis L and Сalendula officinalis. Sodium predominates from certain macronutrients, the superiority of which is manifested in Сalendula officinalis when infused. A large amount of calcium also passes into the aqueous-alcoholic infusion from Сalendula officinalis. Copper and zinc prevail among the determined microelements in water extracts of Сalendula officinalis. Comparing the results obtained, we can say in the affirmative about the micro- and macro elements that have passed into extracts that Сalendula officinalis is richer in these substances. Because infusions and extracts are recommended to be added as an additional ingredient to vegetable and fruit juices, their positive infusion on the human body will increase the recommended daily requirement of potassium and sodium. Based on the results of this study, extracts and infusions of Melissa officinalis L and Сalendula officinalis can be considered as an essential source of micronutrients for enriching fruit and vegetable juices in canned food for health purposes
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Rawat, Apeksha. "APHANAMIXIS POLYSTACHYA (WALL) PARKER PHARMACOGNOSTIC PROFILE & MEDICINAL USES." Indian Research Journal of Pharmacy and Science 7, no. 1 (March 2020): 2101–2. http://dx.doi.org/10.21276/irjps.2020.7.1.8.

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Sain, Kiran, Beena Yadav, and Rita Goel. "Profile and Training Exposure of Medicinal Plant Growers." IRA-International Journal of Management & Social Sciences (ISSN 2455-2267) 4, no. 2 (September 7, 2016): 432. http://dx.doi.org/10.21013/jmss.v4.n2.p12.

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<div><p><em>An attempt was made to find out the preference of the subsidiary and off-seasonal occupations of horticultural farmers. The study was conducted on 30 medicinal plant growers of Bhiwani , Hisar and Mohindergarh districts of South West Zone of Haryana state. Maximum number of medicinal plant growers were in the age group of 40-56 years (53.3%), hailed from upper caste (60.0%), had nuclear families (86.6%) with slightly more than half of them (56.6%) having family size of 5-7 members, maximum of them had education upto senior secondary level (36.6%) with land holding upto five acres (40.0%). No formal training was attended by any of the growers before starting cultivation of medicinal plants. They had positive attitude towards majority of the aspects related to medicinal plants. </em></p></div>
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Pereira, M. M. A., A. D. Martins, L. C. Morais, J. Dória, V. P. Cavalcanti, F. A. Rodrigues, M. Pasqual, and J. M. Q. Luz. "The Potential of Agro-homeopathy Applied to Medicinal Plants—A Review." Journal of Agricultural Science 11, no. 4 (March 15, 2019): 500. http://dx.doi.org/10.5539/jas.v11n4p500.

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The homeopathic preparations can influence the growth, secondary metabolites production, essential oil yield and phytochemical profile when applied in the grown of medicinal plants. To compile this review articles from existing literature about basic research related to the use of homeopathic preparation on the cultivation of medicinal plants and its influence on the phytochemical profile, growth, yield and composition of essential oil were collected. The bibliographic research was carried out in scientific databases sites&mdash;Scopus, Web of Science and PubMed. Seventeen publications were found in which homeopathy was applied in the cultivation of medicinal plants. Its use changed the phytochemical profile, increased the essential oil yield, the production of secondary metabolites (coumarins, alkaloids, phenylpropanoids), the the nutrients absorption and the growth of the medicinal plant species were studied. This review shows that the application of homeopathic preparations in the cultivation of medicinal plants increases the production of secondary metabolites and essential oils that are important for human and animal health therapeutic treatments.The homeopathic preparation application is an alternative for the growth of medicinal plants with ecological balance, and without soil and water contamination. It is also affordable to farmers and researchers. However, further studies are required on its influence on the phytochemical profile of the cultivated medicinal species.
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Mazzari, André Luis D. A., Samantha Frangos, Damaris Silveira, Francisco de Assis Rocha Neves, Flora Milton, Ana Cecília Carvalho, and Jose M. Prieto. "Preclinical pharmacokinetic profile of four traditional medicinal plants." Drug Metabolism and Pharmacokinetics 32, no. 1 (January 2017): S67. http://dx.doi.org/10.1016/j.dmpk.2016.10.270.

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Mazzari, ALDA, S. Frangos, D. Silveira, F. de Assis Rocha Neves, F. Milton, AC Bezerra Carvalho, and JM Prieto. "Preclinical pharmacokinetic profile four native Brazilian medicinal plants." Planta Medica 81, S 01 (December 14, 2016): S1—S381. http://dx.doi.org/10.1055/s-0036-1596971.

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Mrabti, Hanae Naceiri, Latifa Doudach, Mouna Mekkaoui, Zineb Khalil, Khouloud Harraqui, Fozia Fozia, Nidal Naceiri Mrabti, et al. "Profile of Medicinal Plants Traditionally Used for the Treatment of Skin Burns." Evidence-Based Complementary and Alternative Medicine 2022 (June 6, 2022): 1–10. http://dx.doi.org/10.1155/2022/3436665.

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Moroccan folk healers use medicinal plants to treat several diseases including skin burns. The traditional knowledge of wound healing is not common among the general population. Only one ethnobotanical survey was carried out in Rabat, Morocco, to track the traditional use of medicinal plants in wound healing. Therefore, our report aimed to study the medicinal plants used in Taza region to treat wound healing. In total, 218 individuals participated in this survey. More than 40 medicinal plants belonging to 30 botanical families were cited as anti-burn remedies. The most commonly used medicinal plants were Agave sisalana L., Nerium oleander L., Tetraclinis articulata Benth., Lawsonia inermis L., Artemisia herba-alba Asso., and Trigonella foenum-graecum L. Most of the used medicinal plants belong to Asteraceae family. Comparing our results with the previous survey, we noted that twelve plants were reported for the first time as wound healing agents. The ethnomedicinal use showed that plants leaves are the most commonly used parts. Pulverization was the selected method of preparation. The direct application of powder to the burns was the most common way of treatment. Our study revealed, for the first time, the importance of medicinal plants to treat skin burns in Taza region. Our results could be considered as the stepping stone for creating a database of wound healing medicinal plants to promote scientific studies on these plants revealing their constituents and side effects.
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Meena, Ajay Kumar, P. Rekha, and T. Satheesh Kumar. "Ethnobotanical, phytochemical and pharmacological profile of Trichosanthes tricuspidata: An updated review." IP International Journal of Comprehensive and Advanced Pharmacology 6, no. 3 (October 15, 2021): 102–7. http://dx.doi.org/10.18231/j.ijcaap.2021.019.

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Herbal medicines, the backbone of traditional medicine in many countries have played an important role in curing the various diseases of humans and animals since ancient time. Medicinal plants are great source of bioactive compounds that have potential beneficial effects in human life. Electronic databases including PubMed, Google Scholar, books and other sources were searched using subject specific key words that were matched by Trichosanthes tricuspidata medicinal plant related useful information on botanical description, plant distribution, ethanobotanical & therapeutic uses, chemical constituents and pharmacological activity etc. Trichosanthes tricuspidata have many medicinal properties like antioxidant, anticancer, antibacterial, antifungal, Larvicidal activity, Anticonvulsant activity, Gastro protective activity and other activities. The Bioactive compounds of Trichosanthes tricuspidata responsible for its various medicinal properties and their effects at the molecular level need to be investigated in more detail. The present review summarizes the Ethnobotanical & therapeutic uses, chemical constituents and pharmacological activity information of Trichosanthes tricuspidata. The pharmacological properties of bioactive compounds in Trichosanthes tricuspidata are required to confirm the ethno medicinal or traditional claims of Trichosanthes tricuspidata for pharmaceutical therapeutic applications.
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Dissertations / Theses on the topic "Medicinal profile"

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Faraone, Immacolata. "Pharmacological potential and phytochemical profile of three unexplored medicinal plants." Doctoral thesis, Universita degli studi di Salerno, 2019. http://elea.unisa.it:8080/xmlui/handle/10556/4256.

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2017 - 2018
Nature is a wide source of biologically active compounds investigated with the purpose to be used as drugs due to their biological activity and also useful in pharmaceutical discovery and drug design. Nowadays, medicinal plants play a major role in primary health care as therapeutic remedies in many developing countries. The aim of my PhD project was the phytochemical and biological investigation of three plant species, used in Bolivian traditional medicine, but few scientific studies were reported, such as: Azorella glabra Wedd., Minthostachys diffusa Epl. and Senecio clivicolus Wedd. On the basis of ethnobotanical uses, the samples were firstly analysed for their total content of polyphenols, flavonoids and terpenoids and for their in vitro antioxidant activity using different complementary assays. In particular, radical scavenging activity was tested against biological radicals such as nitric oxide (NO) and superoxide (SO) together with neutral or cationic (DPPH and ABTS) radicals; ferric reducing power and lipid peroxidation inhibitory capacity (FRAP and Beta-Carotene Bleaching tests) were also determined. Oxidative stress is involved in different diseases, such as diabetes and neurodegenerative diseases. Then, the inhibitory ability of samples was investigated against α-amylase and α-glucosidase enzymes involved in diabetes and against acetylcholinesterase and butyrylcholinesterase enzymes considered as strategy for the treatment of Parkinson’s or Alzheimer’s diseases. Moreover, cytotoxicity studies on cancer and non-cancer cell lines were carried out. The antioxidant, antidiabetic, anticholinesterase and cytotoxic activities and the phytochemical profile were performed on aerial parts of A. glabra, M. diffusa and S. clivicolus for the first time. Among all samples, the ethyl acetate fraction of S. clivicolus showed the highest antioxidant activity; instead, M. diffusa samples showed the highest antidiabetic potential and anti-cholinesterase activities. To confirm the inhibitory cholinesterase effects of the terpenes identified from M. diffusa, in silico docking analysis were also carried out. Moreover, the A. glabra samples were tested for the first time on Multiple Myeloma (MM) cell lines using several assays. The chloroform fraction of A. glabra reduced the cell viability, and arrested the cell cycle on MM cells in G0/G1 phase, characteristic feature of apoptosis. Instead, the ethyl acetate fraction of S. clivicolus was tested on hepatocellular carcinoma HepG2 cell line showed the ability to induct cell death via the mitochondrial apoptotic pathway. In conclusion, this first report on A. glabra, M. diffusa and S. clivicolus phytochemical characterization and biological activity evaluation, demonstrates as these Bolivian plant species could be considered a source of health promoting compounds. Some of the results obtained during this study might partially explain their ethnobotanical use, evidencing a potential economic added value for extract future use in the field of biotechnology applied to environmental, agricultural, health, pharmaceutical and cosmeceutical development. [edited by Author]
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Labar, Reha. "Medicinal and molecular profiling of selected tea varieties of Darjeeling and Dooars." Thesis, University of North Bengal, 2022. http://ir.nbu.ac.in/handle/123456789/5085.

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Pal, Arindom. "Development of a new class of ligand-targeted chemotherapeutics with enhanced safety and efficacy profile." Scholarly Commons, 2019. https://scholarlycommons.pacific.edu/uop_etds/3642.

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The hydrophobicity of many chemotherapeutic agents usually results in their nonselective passive distribution into healthy cells and organs causing collateral toxicity. Ligand-targeted drugs (LTDs) are a promising class of targeted anticancer agents. The hydrophilicity of the targeting ligands in LTDs limits its nonselective passive tissue distribution and toxicity to healthy cells. In addition, the small size of LTDs allows for better tumor penetration, especially in the case of solid tumors. However, the short circulation half-life of LTDs, due to their hydrophilicity and small size, remains a significant challenge for achieving their full therapeutic potential. Therefore, extending the circulation half-life of targeted chemotherapeutic agents while maintaining their hydrophilicity and small size will represent a significant advance towards effective and safe cancer treatment. Here, we present a new approach for enhancing the safety and efficacy of targeted chemotherapeutic agents. By endowing hydrophobic chemotherapeutic agents with a targeting moiety and a hydrophilic small molecule that binds reversibly to the serum protein transthyretin, we generated small hydrophilic drug conjugates that displayed enhanced circulation half-life in rodents and selectivity to cancer cells. To the best of our knowledge, this is the first demonstration of a successful approach that maintains the small size and hydrophilicity of targeted anticancer agents containing hydrophobic payloads, while at the same time extending their circulation half-life. This was demonstrated by the superior in vivo efficacy and lower toxicity of our conjugates in xenograft mouse models of metastatic prostate cancer.
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Mandrone, Manuela <1983&gt. "Medicinal Plants from Ancient Tradition as a Source for Matrix Proteases Inhibitors. Study of Correlation between Biological Activity and Phytochemical Profile." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amsdottorato.unibo.it/7613/1/tesi_Manuela_Mandrone_.pdf.

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Considering the crucial involvement of matrix metalloproteinases’ (MMPs) misregulated activity in the pathogenesis of several degenerative diseases, this class of enzymes has been considered a highly active set of targets for the design of new therapeutic agents. However, the scant success of synthetic MMP inhibitors, largely due to the disappointing results obtained in both clinical and preclinical studies, makes medicinal plants a valuable source of new active compounds able to modulate MMPs activity. In this work, a consistent number of plants, selected on the base of an ethnobotanical research, were tested as inhibitors of collagenase, the founding member of the MMPs family. 1H-NMR-based metabolomic analysis combined with multivariate data treatment (PLS and OPLS) was used to correlate the biological activity to the phytochemical profiles, suggesting tannins as an important class of collagenase inhibitors. Thus, a tannin-removal procedure was developed, which allowed to prove this hypothesis and to identify another class of active metabolites, the glucuronide-conjugated flavonoids (especially quercetin-3-O-β-glucoronide), whose the plant Alchemilla vulgaris was found to be a good source. In another stage of the project, different varieties of tea were investigated as collagenase inhibitors, finding black tea samples particularly potent. Then, an OPLS model was developed with the aim of correlating the biological activity to the UV-Vis spectra of teas, showing that a high activity was related to absorption values in the range 350-440 nm. A subsequent fractionation of the most active tea sample was carried out, and this approach allowed to corroborate the results obtained by the metabolomic analysis. Considering that the absorbance measurement of an extract represents a cheap and simple procedure, the proposed method can be suitable, for instance, to select the best tea variety to be developed as an anti-wrinkles cosmetic or food supplement.
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Mandrone, Manuela <1983&gt. "Medicinal Plants from Ancient Tradition as a Source for Matrix Proteases Inhibitors. Study of Correlation between Biological Activity and Phytochemical Profile." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amsdottorato.unibo.it/7613/.

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Considering the crucial involvement of matrix metalloproteinases’ (MMPs) misregulated activity in the pathogenesis of several degenerative diseases, this class of enzymes has been considered a highly active set of targets for the design of new therapeutic agents. However, the scant success of synthetic MMP inhibitors, largely due to the disappointing results obtained in both clinical and preclinical studies, makes medicinal plants a valuable source of new active compounds able to modulate MMPs activity. In this work, a consistent number of plants, selected on the base of an ethnobotanical research, were tested as inhibitors of collagenase, the founding member of the MMPs family. 1H-NMR-based metabolomic analysis combined with multivariate data treatment (PLS and OPLS) was used to correlate the biological activity to the phytochemical profiles, suggesting tannins as an important class of collagenase inhibitors. Thus, a tannin-removal procedure was developed, which allowed to prove this hypothesis and to identify another class of active metabolites, the glucuronide-conjugated flavonoids (especially quercetin-3-O-β-glucoronide), whose the plant Alchemilla vulgaris was found to be a good source. In another stage of the project, different varieties of tea were investigated as collagenase inhibitors, finding black tea samples particularly potent. Then, an OPLS model was developed with the aim of correlating the biological activity to the UV-Vis spectra of teas, showing that a high activity was related to absorption values in the range 350-440 nm. A subsequent fractionation of the most active tea sample was carried out, and this approach allowed to corroborate the results obtained by the metabolomic analysis. Considering that the absorbance measurement of an extract represents a cheap and simple procedure, the proposed method can be suitable, for instance, to select the best tea variety to be developed as an anti-wrinkles cosmetic or food supplement.
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Xi, Jia. "Modulation of oleanolic acid dissolution profile via solid state manipulation and self-nanoemulsifying drug delivery systems (SNEDDS)." Thesis, University of Macau, 2008. http://umaclib3.umac.mo/record=b2158690.

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Brown, Dustin Paul. "TARGET-DIRECTED BIOSYNTHETIC EVOLUTION: REDIRECTING PLANT EVOLUTION TO GENOMICALLY OPTIMIZE A PLANT’S PHARMACOLOGICAL PROFILE." UKnowledge, 2015. http://uknowledge.uky.edu/neurobio_etds/13.

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The dissertation describes a novel method for plant drug discovery based on mutation and selection of plant cells. Despite the industry focus on chemical synthesis, plants remain a source of potent and complex bioactive metabolites. Many of these have evolved as defensive compounds targeted on key proteins in the CNS of herbivorous insects, for example the insect dopamine transporter (DAT). Because of homology with the human DAT protein some of these metabolites have high abuse potential, but others may be valuable in treating drug dependence. This dissertation redirects the evolution of a native Lobelia species toward metabolites with greater activity at this therapeutic target, i.e. the human DAT. This was achieved by expressing the human DAT protein in transgenic plant cells and selecting gain-of-function mutants for survival on medium containing a neurotoxin that is accumulated by the human DAT. This created a sub-population of mutants with increased DAT inhibitory activity. Some of the active metabolites in these mutants are novel (i.e. not detectable in wild-type cells). Others are cytoprotective, and also protect DAergic neurons against the neurotoxin. This provides proof-of-concept for a novel plant drug discovery platform, which is applicable to many different therapeutic target proteins and plant species.
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Strindhall, Jan, Mårten Skog, Jan Ernerudh, M. Bengner, S. Lofgren, A. Matussek, B. O. Nilsson, and A. Wikby. "The inverted CD4/CD8 ratio and associated parameters in 66-year-old individuals : the Swedish HEXA immune study." Linköpings universitet, Cellbiologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-93380.

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The Swedish OCTO and NONA immune longitudinal studies were able to identify and confirm an immune risk profile (IRP) predictive of an increased 2-year mortality in very old individuals, 86–94 years of age. The IRP, was associated with persistent cytomegalovirus infection and characterized by inverted CD4/CD8 ratio and related to expansion of terminally differentiated effector memory T cells (TEMRA phenotype). In the present HEXA immune longitudinal study, we have examined a younger group of elderly individuals (n = 424, 66 years of age) in a population-based sample in the community of Jönköping, Sweden, to examine the relevance of findings previously demonstrated in the very old. Immunological monitoring that was conducted included T cell subsets and CMV-IgG and CMV-IgM serology. The result showed a prevalence of 15 % of individuals with an inverted CD4/CD8 ratio, which was associated with seropositivity to cytomegalovirus and increases in the level of TEMRA cells. The proportion of individuals with an inverted CD4/CD8 ratio was significantly higher in men whereas the numbers of CD3+CD4+ cells were significantly higher in women. In conclusion, these findings are very similar to those previously found by us in the Swedish longitudinal studies, suggesting that an immune profile previously identified in the very old also exists in the present sample of hexagenerians. Therefore, it will be important to examine clinical parameters, including morbidity and mortality, to assess whether the immune profile also is a risk profile associated with higher mortality in this sample of hexagenerians.

Funding Agencies|Medical Research Council of South-East Sweden||

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Barrero, Franquet Anna. "Ultra-endurance triathlon: heart rate-based intensity profile, energy balance, muscle damage and race performance." Doctoral thesis, Universitat de Barcelona, 2014. http://hdl.handle.net/10803/362661.

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This thesis presents the results of two research studies related to the physiological demands, the energy balance and the muscle damage induced by an ultra-endurance triathlon. The first study of this thesis examined the heart rate response during an ultra-endurance triathlon race in relation with heart rate-based intensity markers derived from specific swimming, cycling and running incremental tests. We found that, contrary to what was believed until now, the absolute or relative heart rate (expressed as percentage of heart rate peak) is greater in the swimming stage than in the cycling and running stages. It was also observed that swimming at a higher intensity inversely correlated with performance during the following stages and the overall racing performance. Moreover it was found that 81% of the variance in total racing time was explained by the weight-adjusted VO2max and the heart rate difference between the running and swimming stages. Furthermore, our data support the concept of an "oxygen consumption ultra-endurance threshold". The second study provided proper characterization of the energy and fluid intake, as well as the estimated energy expenditure, of a group of male triathletes during an entire UET race. The estimated EE was aprox. 11000 kcal (46 MJ), whereas EI was only aprox. 3600 kcal (15 MJ), which resulted in an energy deficit of almost 70%. This result partially confirms our hypothesis and demonstrates the challenging metabolic demands of a UET. In this study it was as well assessed the muscle damage induced by a UET and its relationship with the hydration status. The results, beyond confirming fibre muscle damage induced by an UET race, strongly suggest that cellular structural damage predominantly affects slow fibres, and that muscle damage is related to the hydration status.
En aquesta tesi es presenten els resultats de 2 estudis d'investigació relacionats amb les demandes fisiològiques, el balanç energètic i el dany muscular en els triatlons d'ultra-resistència. L'èxit en el triatló d'ultra-resisténcia està regit per la capacitat de mantenir una velocitat absoluta superior per una donada distància, en comparació amb els altres competidors (Zaryski & Smith, 2005). Per optimitzar el rendiment i determinar els factors de rendiment és necessari conèixer la resposta fisiològica i els requeriments energètics durant la competició. El perfil d'intensitat durant un triatló pot ajudar a entendre les demandes fisiològiques i proporcionar informació essencial per a l'entrenament òptim dels triatletes que competeixen en aquests tipus d'esdeveniments. A més a més, donada la llarga durada d'aquests esdeveniments esportius, un dels principals objectius per als atletes és la gestió del consum d'aliments i begudes durant la cursa (Laursen & Rhodes, 2001) per tal de millorar el rendiment i el manteniment de l'homeòstasi del cos. La informació en aquest camp és escassa o gairebé nul•la. Un altre punt clau que afecta aquests triatlons és el dany muscular que pateixen els atletes, que pot disminuir el rendiment muscular i, per tant, afectar el rendiment final del triatló. Un programa d'entrenament de força orientat a produir adaptacions musculars podria reduir aquest dany, però primer cal conèixer quines són les fibres musculars afectades. D'acord als punts exposats, els objectius plantejats en aquesta tesi han sigut: • Proveir, per primera vegada, una caracterització comprensiva del perfil d'intensitat basat en la freqüència cardíaca durant un triatló d'ultra-resistència. Aquest perfil d'intensitat s' estimarà en funció de la relació freqüència cardíaca-consum d'oxigen obtinguda en tests específics en cadascun dels tres modes d' exercici. • Relacionar els paràmetres fisiològics de laboratori i de camp mesurats amb el rendiment en la competició. • Proveir una caracterització del consum d'energia i líquids durant la totalitat d'un triatló d'ultra-resistència. • Estimar la despesa energètica i el balanç de fluids (dipòsits intra i extracel·lulars) al llarg de la competició utilitzant les tres equacions individualitzades obtingudes de cada triatleta. • Avaluar el dany muscular produït per un triatló d’ultra-resistència mitjançant l’avaluació dels nivells de sèrum de les miosines ràpides i lentes, i dels nivells d’activitat de la creatina kinasa. • Relacionar el dany muscular amb el nivell d’hidratació dels atletes. Els resultats i conclusions derivats d’aquests dos estudis que conformen la tesis han sigut: La freqüència cardíaca mitjana durant la competició va ser superior durant el -1 segment de natació (149.2 (10.1) batecs·min ) que durant el segments de ciclisme -1 -1 (137.1 (5.7) batecs·min ) i cursa a peu (136.2 (10.5) batecs·min ). Durant aquests dos últims segments la freqüència cardíaca va estar per sota dels dos llindars ventilatoris (aprox. 11% i aprox. 27-28%) mentre que en el segment de natació la freqüència cardíaca es va situar al voltant del segon llindar ventilatori. Les diferències en la freqüència cardíaca entre el segment de natació i el segment de ciclisme van obtenir una forta correlació amb els temps dels segments de ciclisme i cursa a peu, així com també amb el temps final; com més gran va ser la diferència entre la natació i el ciclisme, pitjors resultats van obtenir els subjectes. Per tant, es pot afirmar que el segment de natació en un triatló d’ultra-resistència es desenvolupa en una intensitat relativa superior als altres dos segments i que aquesta intensitat està relacionada amb un pitjor rendiment als següents segments. El consum d’energia va ser de 3.643 (1.219) kcal i la despesa energètica estimada va ser de 11.009 (664) kcal. En conseqüència, els atletes van mostrar un dèficit d'energia de 7.365 (1.286 kcal (66,9 (11,7%)) posant de manifest les altes demandes energètiques d’aquests tipus de competició, que no són compensades per la ingesta de nutrients i líquids, resultant en un dèficit energètic de grans dimensions. La massa corporal va disminuir significativament després de finalitzar el triatló i també es van trobar pèrdues significatives en l’aigua total corporal. Aquestes pèrdues van estar més relacionades amb la reducció dels fluids extracel·lulars que amb la reducció dels fluids intracel·lulars. Els paràmetres que millor prediuen el rendiment (expressat com a temps final de cursa) en els triatlons d’ultra-resistència són el consum màxim d'oxigen relatiu i la diferència entre la freqüència cardíaca entre el segment de ciclisme i natació. Una caracterització del patró d’intensitat durant tota la cursa, especialment del segment de natació, afegeix nova informació del perfil d'intensitat i les demandes cardiovasculars d'un triatló d’ultra-resistència, la qual cosa remarca la importància de l’especificitat en els tests per avaluar el perfil fisiològic de cara a preparar els entrenaments i l’estratègia de competició. Un triatló d’ultra-resistència provoca dany muscular afectant principalment les fibres musculars ‘lentes’. Un programa d’entrenament orientat a la producció d’adaptacions a les fibres musculars lentes, pot ajudar a reduir el dany muscular produït durant un triatló d’ultra-resistència. El dany muscular produït en triatlons d’ultra-resistència està relacionat amb el grau d’hidratació durant la competició i, per tant, els triatletes haurien d’evitar la deshidratació per, entre altres coses, prevenir el deteriorament del múscul.
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Crawshaw, Anjali Priya. "Monocyte profile and function in sarcoidosis." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:3378bf46-a494-45a0-b68e-81b37c1dae49.

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Sarcoidosis is a multisystem inflammatory disorder of unknown aetiology. The immune pathology is characterised by dysregulated T cell (TH1) activity, macrophage activation and granuloma formation, resulting in systemic inflammation, and organ dysfunction. I hypothesised that, as the systemic precursor to the macrophage, altered monocyte activity in sarcoidosis may contribute to the early immune pathology of the disease. In this thesis, I examined their phenotype, four key monocytic functions: cytokine production, suppression of T cell proliferation, phagocytosis and fusion (as a precursor to granulomagenesis); and their gene expression profile compared to monocytes from healthy controls. My data show that the expanded monocyte compartment comprise a greater proportion of the inflammatory (CD14++CD16+) and patrolling (CD14+CD16++) subsets, increased TNFα and IL-12 and decreased IL-10 and IL-4 production in sarcoidosis compared with healthy controls. The IL-10 deficit renders the monocytes less able to regulate T cell proliferation or their own fusion to multinucleate giant cells, potentially contributing to T cell expansion and granuloma formation respectively. Additionally, sarcoidosis monocytes are less able to phagocytose inert material. I also showed that previously reported deficiency in invariant NKT cells and low serum vitamin D levels in sarcoidosis may be linked to reduced IL-10 production by monocytes. Vitamin D treatment in vitro restored most of these deficiencies and provides a potential therapeutic method for manipulating monocyte function and disease genesis in sarcoidosis.
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Books on the topic "Medicinal profile"

1

Creating your herbal profile. New Canaan, Conn: Keats Pub., 1991.

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K, Warrier P. Some important medicinal plants of the Western Ghats, India: A profile. New Delhi: Medicinal and Aromatic Plants Program in Asia (MAPPA), International Development Research Centre (IDRC), Canada, South Asia Regional Office (SARO), 2001.

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J, Pasko Thomas, ed. Specialty profiles. Chicago, Ill: Dept. of Physician Data Services, Division of Survey and Data Resources, American Medical Association, 1988.

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1954-, Allan Barbara, ed. Medical information: A profile. White Plains, N.Y: Knowledge Industry Publications, 1986.

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Tribhuvana Viśvavidyālaya. Institute of Medicine. Profile, Institute of Medicine. Kathmandu: Health Learning Materials Centre, Institute of Medicine, 1999.

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Razzack, Mohammed Abdur. Unani system of medicine in India: A profile. 2nd ed. New Delhi: Central Council for Research in Unani Medicine, 1991.

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Tchoubarov, Victor. Human being biorythmical profile and traditional Chinese medicine. Hamburg: Verlag Dr. Kovac, 1996.

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Canada. Industry, Science and Technology Canada. Pharmaceuticals and medicines =: Profil de l'industrie: médicaments et produits pharmaceutiques. Ottawa, Ont: Industry, Science and Technology Canada, 1988.

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J, Arkin A., Magyar K. P, and Pillay G. J, eds. The Indian South Africans: A contemporary profile. Pinetown, South Africa: Owen Burgess, 1989.

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Chubarov, V. A. Bioritmologicheskiĭ profilʹ cheloveka i tradit͡s︡ionnai͡a︡ kitaĭskai͡a︡ medit͡s︡ina. Sankt-Peterburg: Mezhdunar. t͡s︡entr ėkonomiki, nauki, i tekhniki, 1993.

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Book chapters on the topic "Medicinal profile"

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Zeb, Alam, and Muhammad Ayaz. "Traditional Uses, Important Phytochemicals, and Therapeutic Profile of Persicaria hydropiper." In Aquatic Medicinal Plants, 13–36. Boca Raton: CRC Press, 2023. http://dx.doi.org/10.1201/9781003256830-2.

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Gupta, Prakash Chandra, and Nisha Sharma. "An Overview of Traditional Uses and Pharmacological Profile of Sphaeranthus indicus." In Aquatic Medicinal Plants, 121–32. Boca Raton: CRC Press, 2023. http://dx.doi.org/10.1201/9781003256830-8.

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Laldinchhana, probin Kumar Roy, and Lalduhsanga Pachuau. "Phytochemical and Pharmacological Profile of Rubus idaeus." In Bioactives and Pharmacology of Medicinal Plants, 329–38. Boca Raton: Apple Academic Press, 2022. http://dx.doi.org/10.1201/9781003281702-26.

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Raja, Kullayiswamy K., and Devi N. Sarojini. "Phytochemical and Pharmacological Profile of Syzygium Aromaticum (Clove)." In Biomolecules and Pharmacology of Medicinal Plants, 137–51. New York: Apple Academic Press, 2023. http://dx.doi.org/10.1201/9781003284444-10.

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Okhale, Samuel. "Phytochemical and Pharmacological Profile of Garcinia Kola Heckel." In Biomolecules and Pharmacology of Medicinal Plants, 233–44. New York: Apple Academic Press, 2023. http://dx.doi.org/10.1201/9781003284444-17.

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Khanal, Lekha Nath, Surya Kant Kalauni, and Yuba Raj Pokharel. "Phytochemical and Pharmacological Profile of Arctium Lappa L." In Biomolecules and Pharmacology of Medicinal Plants, 373–99. New York: Apple Academic Press, 2023. http://dx.doi.org/10.1201/9781003284444-29.

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Bruce, Stella Omokhefe, and Veronica Ogochukwu Onyemailu. "Phytochemical and Pharmacological Profile of Olea Europaea L." In Biomolecules and Pharmacology of Medicinal Plants, 105–14. New York: Apple Academic Press, 2023. http://dx.doi.org/10.1201/9781003284444-7.

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Mahesh, P., M. Shanthala, M. Basavaraja, and S. Rajashekara. "Phytochemical and Pharmacological Profile of Daphne Mucronata Royle." In Biomolecules and Pharmacology of Medicinal Plants, 319–27. New York: Apple Academic Press, 2023. http://dx.doi.org/10.1201/9781003284444-24.

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Shukla, Vijaya, Vikas Bajpai, and Brijesh Kumar. "Phytochemical and Pharmacological Profile of Dillenia Pentagyna Roxb." In Biomolecules and Pharmacology of Medicinal Plants, 117–24. New York: Apple Academic Press, 2023. http://dx.doi.org/10.1201/9781003284468-10.

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Raja, Kullayiswamy K., and Devi N. Sarojini. "Phytochemical and Pharmacological Profile of Syzygium Aromaticum (Clove)." In Biomolecules and Pharmacology of Medicinal Plants, 137–51. New York: Apple Academic Press, 2023. http://dx.doi.org/10.1201/9781003284444_10.

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Conference papers on the topic "Medicinal profile"

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Nitulescu, Georgiana, George Mihai Nitulescu, and Daniela Grădinaru. "Structural profile of collagenase inhibitors." In 7th International Electronic Conference on Medicinal Chemistry. Basel, Switzerland: MDPI, 2021. http://dx.doi.org/10.3390/ecmc2021-11489.

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Pattar, Mohanraj, Soumya, B. R. Kerur, Balaji Biradar, Manjunath A., Mahalesh D., and Shranabasamma Amabalagi. "Elemental profile of herb and medicinal plant using spectro analytical AAS technique." In PROF. DINESH VARSHNEY MEMORIAL NATIONAL CONFERENCE ON PHYSICS AND CHEMISTRY OF MATERIALS: NCPCM 2018. Author(s), 2019. http://dx.doi.org/10.1063/1.5098718.

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Melnichuk, Nataliia, Viktor Liashko, Vladimir Kashuba, and Zenoviy Tkachuk. "Gene expression profile in peripheral blood cells of patients with COVID-19." In 6th International Electronic Conference on Medicinal Chemistry. Basel, Switzerland: MDPI, 2020. http://dx.doi.org/10.3390/ecmc2020-07298.

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Suravarjhula, Venkat Kaushik, Sai Teja Manam, Jawahar Venkatesan, SriCharan Alluri, and B. Sabarish Narayanan. "Cement Based Composite Loaded with Medicinal Package Waste for Low Profile Electromagnetic Shielding." In 2018 USNC-URSI Radio Science Meeting (Joint with AP-S Symposium). IEEE, 2018. http://dx.doi.org/10.1109/usnc-ursi.2018.8602658.

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Nowakowski, Robert, Beniamin Grabarek, Magdalena Gradzik, Paweł Ordon, Hanna Zientek, Oskar Ogloszka, Kacper Boroń, Marcin Oplawski, Dariusz Boroń, and Marcin Gralewski. "Variances in the expression profile of histaminergic system in the endometroid endometrial cancer." In 7th International Electronic Conference on Medicinal Chemistry. Basel, Switzerland: MDPI, 2021. http://dx.doi.org/10.3390/ecmc2021-11425.

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Grabarek, Beniamin, Magdalena Mistarz, Weronika Wieczorek, Dorian Gładysz, and Tomasz Kasela. "Effect of adalimumab on the expression profile of genes encoding histamine receptors in keratinocyte." In 7th International Electronic Conference on Medicinal Chemistry. Basel, Switzerland: MDPI, 2021. http://dx.doi.org/10.3390/ecmc2021-11418.

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Breda, Cristiana, Irene Gouvinhas, and Ana Isabel Barros. "Characterization of the phenolic profile of edible flowers as a source of natural antioxidants." In 7th International Electronic Conference on Medicinal Chemistry. Basel, Switzerland: MDPI, 2021. http://dx.doi.org/10.3390/ecmc2021-11539.

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Melnichuk, Nataliia, Tetiana Marchyshak, Vladimir Kashuba, Ivan Smolanka, Petro Okhrimenko, and Zenoviy Tkachuk. "Expression profile of innate immune genes in peripheral blood mononuclear cells as early detection of breast cancer." In 5th International Electronic Conference on Medicinal Chemistry. Basel, Switzerland: MDPI, 2019. http://dx.doi.org/10.3390/ecmc2019-06336.

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Abreu-Guirado, Orlando, Kenn Foubert, Julio Escalona-Arranz, Daniel Méndez-Rodríguez, Andrés Rivera-Mondragón, Paul Cos, and Luc Pieters. "Phytochemical MS profile of Cuban &lt;em&gt;Piper aduncum&lt;/em&gt; L. subspecies." In 7th International Electronic Conference on Medicinal Chemistry. Basel, Switzerland: MDPI, 2021. http://dx.doi.org/10.3390/ecmc2021-11498.

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Rusu, Marius, Andrei Mocan, Ana-Maria Gheldiu, Ioan Tomuta, Laurian Vlase, and Daniela-Saveta Popa. "Method optimization for enhanced bioactive compounds extraction from hazelnut (Corylus avellana L.) involucre: Phytochemical profile and antioxidant activity." In 4th International Electronic Conference on Medicinal Chemistry. Basel, Switzerland: MDPI, 2018. http://dx.doi.org/10.3390/ecmc-4-05570.

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Reports on the topic "Medicinal profile"

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Collington, Rosie, and William Lazonick. Pricing for Medicine Innovation: A Regulatory Approach to Support Drug Development and Patient Access. Institute for New Economic Thinking Working Paper Series, January 2022. http://dx.doi.org/10.36687/inetwp176.

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The United States represents the world’s largest market for pharmaceutical drugs. It is also the only advanced economy in the world that does not regulate drug prices. There is no upper threshold for the prices of medicines in the United States. List prices are instead set by manufacturers in negotiation with supply-chain intermediaries, though some federal programs have degrees of discretion in price determinations. In practice, this deregulated system means that drug prices in the United States are generally far higher than in other advanced economies, adversely affecting patient accessibility and system affordability. In this paper, we draw on the “theory of innovative enterprise” to develop a framework that provides both a critique of the existing pricing system in the United States and a foundation for developing a new model of pricing regulation to support safety and effectiveness through drug development as well as accessibility and affordability in the distribution of approved medicines to patients. We introduce a regulatory approach we term “Pricing for Medicine Innovation” (PMI), which departs dramatically from the market-equilibrium assumptions of conventional (neoclassical) economics. The PMI approach recognizes the centrality of collective investments by government agencies and business firms in the productive capabilities that underpin the drug development process. PMI specifies the conditions under which, at the firm level, drug pricing can support both sustained investment in these capabilities and improved patient access. PMI can advance both of these objectives simultaneously by regulating not just the level of corporate profit but also its allocation to reinvestment in the drug development process. PMI suggests that although price caps are likely to improve drug affordability, there remain two potential issues with this pricing approach. Firstly, in an innovation system where a company’s sales revenue is the source of its finance for further drug development, price caps may deprive a firm of the means to invest in innovation. Secondly, even with adequate profits available for investment in innovation, a firm that is run to maximize shareholder value will tend to use those profits to fund distributions to shareholders rather than for investment in drug innovation. We argue that, if implemented properly, PMI could both improve the affordability of medicines and enhance the innovative performance of pharmaceutical companies.
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Azoulay, Pierre, and Ariel Fishman. The Rise of For-Profit Experimental Medicine. Cambridge, MA: National Bureau of Economic Research, March 2020. http://dx.doi.org/10.3386/w26892.

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Ștefănescu, Ruxandra, Eszter Laczkó-Zöld, Bianca-Eugenia Ősz, and Camil-Eugen Vari. An updated systematic review of Vaccinium myrtillus leaves: phytochemistry and pharmacology. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, December 2022. http://dx.doi.org/10.37766/inplasy2022.12.0029.

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Review question / Objective: This review aims to present the latest knowledge on the phytochemical profile as well as the therapeutic effects of Vaccinium myrtillus leaves. Background: The leaves are used in traditional medicine of different countries for the management of diabetes. Until date there are no relevant information, only assumptions regarding the compounds that are responsible for this effect Bilberry leaves are used in many countries in traditional medicine for treating a wide variety of diseases. Well documented in the literature, the influence of pedo-climatic conditions is an important factor that is responsible for the noticeable differences among the chemical composition of herbal drugs, and also the accumulation of different metals, having significant effects on the quality of plant products.
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Bhattacharya, Jay, and Mikko Packalen. Is Medicine an Ivory Tower? Induced Innovation, Technological Opportunity, and For-Profit vs. Non-Profit Innovation. Cambridge, MA: National Bureau of Economic Research, March 2008. http://dx.doi.org/10.3386/w13862.

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Weng, JIeqiong, Jingfang Zhang, Ke Xu, Mengfei Yuan, Tingting Yao, Xinyu Wang, and Xiaoxu Shen. Efficacy of Shexiang Baoxin Pills Combined with Statins on Blood Lipid Profile in Patients with Coronary Heart Disease: A systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, September 2022. http://dx.doi.org/10.37766/inplasy2022.9.0100.

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Review question / Objective: P（Population) ：Patients with coronary heart disease; I（Intervention) : Statins treatment in combination with Shexiang Baoxin pill; C（Comparison): Statins alone; O（Outcome）: Improvement of symptoms and blood lipids; S（Study design）：Clinical randomized trials. Eligibility criteria: To be included, trials were required to meet the following criteria: (1) patients were included in the studies according to diagnostic criteria of coronary heart disease established by the WHO, InternationalSociety of Cardiology and Association (ISCA), Internal Medicine, 7th edition ( IM-7th), Practice of InternalMedicine, 14th edition ( PIM-14th), Guidelines for the Diagnosis of Cardiovascular Diseases in InternalMedicine, 3rd edition (GIM-3rd) or conventional diagnostic criteria (CDC) including assessment of anginapectoris and electrocardiogram (ECG) results; (2) the study was conducted as a randomized controlled trial.
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Konstantinou, Efrosyni. The Blind Spot: A Study on the Ethical Dilemmas that Senior Leaders and Experts Face in Collaborations Designed to Address Grand Challenges. Association for Project Management, January 2023. http://dx.doi.org/10.61175/xpri9143.

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Since 2018, this study has set out to explore whether the project management profession was ready to address Grand Challenges. This is because the political legitimacy of a newly chartered profession in society depends on the extent to which it contributes to addressing challenges, such as climate change, poverty, lack of sanitation, healthcare, human space exploration and blockchain. Therefore, 62 trailblazers of Grand Challenges Collaborations (GCCs) in medicine, engineering, IT, academia and government were interviewed on the ethical dilemmas they face in GCCs and what they do to overcome them. Our study shows conclusively that ethics is the blind spot of GCCs. Like driving your car at great speed on the motorway where the course of travel can’t change except at specific, far-in-between junctions, GCCs reflect high value, high profile projects where the stakes are high, with little, if any, leeway to changing the purpose of the project. In the same way that upcoming traffic will hide in the blind spot in your rear-view mirrors and can cause a fatal accident when you are changing lanes at high speed, ethics remain in the blind spot of GCCs, and when violated can cause uncontrollable, material damages. In the driving seat, are GCCs trailblazers, that this study defines as senior leaders and experts whose power and influence are formidably channelled in strategically managing GCCs.
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Selph, Shelly S., Andrea C. Skelly, Ngoc Wasson, Joseph R. Dettori, Erika D. Brodt, Erik Ensrud, Diane Elliot, et al. Physical Activity and the Health of Wheelchair Users: A Systematic Review in Multiple Sclerosis, Cerebral Palsy, and Spinal Cord Injury. Agency for Healthcare Research and Quality (AHRQ), October 2021. http://dx.doi.org/10.23970/ahrqepccer241.

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Objectives. Although the health benefits of physical activity are well described for the general population, less is known about the benefits and harms of physical activity in people dependent upon, partially dependent upon, or at risk for needing a wheelchair. This systematic review summarizes the evidence for physical activity in people with multiple sclerosis, cerebral palsy, and spinal cord injury regardless of current use or nonuse of a wheelchair. Data sources. We searched MEDLINE®, CINAHL®, PsycINFO®, Cochrane CENTRAL, Embase®, and Rehabilitation and Sports Medicine Source from 2008 through November 2020, reference lists, and clinical trial registries. Review methods. Predefined criteria were used to select randomized controlled trials, quasiexperimental nonrandomized trials, and cohort studies that addressed the benefits and harms of observed physical activity (at least 10 sessions on 10 different days of movement using more energy than rest) in participants with multiple sclerosis, cerebral palsy, and spinal cord injury. Individual study quality (risk of bias) and the strength of bodies of evidence for key outcomes were assessed using prespecified methods. Dual review procedures were used. Effects were analyzed by etiology of impairment and physical activity modality, such as treadmill, aquatic exercises, and yoga, using qualitative, and when appropriate, quantitative synthesis using random effects meta-analyses. Results. We included 146 randomized controlled trials, 15 quasiexperimental nonrandomized trials, and 7 cohort studies (168 studies in 197 publications). More studies enrolled participants with multiple sclerosis (44%) than other conditions, followed by cerebral palsy (38%) and spinal cord injury (18%). Most studies were rated fair quality (moderate risk of bias). The majority of the evidence was rated low strength. • In participants with multiple sclerosis, walking ability may be improved with treadmill training and multimodal exercise regimens that include strength training; function may be improved with treadmill training, balance exercises, and motion gaming; balance is likely improved with postural control exercises (which may also reduce risk of falls) and may be improved with aquatic exercises, robot-assisted gait training, treadmill training, motion gaming, and multimodal exercises; activities of daily living may be improved with aquatic therapy; sleep may be improved with aerobic exercises; aerobic fitness may be improved with multimodal exercises; and female sexual function may be improved with aquatic exercise. • In participants with cerebral palsy, balance may be improved with hippotherapy and motion gaming, and function may be improved with cycling, treadmill training, and hippotherapy. • In participants with spinal cord injury, evidence suggested that activities of daily living may be improved with robot-assisted gait training. • When randomized controlled trials were pooled across types of exercise, physical activity interventions were found to improve walking in multiple sclerosis and likely improve balance and depression in multiple sclerosis. Physical activity may improve function and aerobic fitness in people with cerebral palsy or spinal cord injury. When studies of populations with multiple sclerosis and cerebral palsy were combined, evidence indicated dance may improve function. • Evidence on long-term health outcomes was not found for any analysis groups. For intermediate outcomes such as blood pressure, lipid profile, and blood glucose, there was insufficient evidence from which to draw conclusions. There was inadequate reporting of adverse events in many trials. Conclusions. Physical activity was associated with improvements in walking ability, general function, balance (including fall risk), depression, sleep, activities of daily living, female sexual function, and aerobic capacity, depending on population enrolled and type of exercise utilized. No studies reported long-term cardiovascular or metabolic disease health outcomes. Future trials could alter these findings; further research is needed to examine health outcomes, and to understand the magnitude and clinical importance of benefits seen in intermediate outcomes.
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