Relevant bibliographies by topics / Medicinal chemistry-Polystyrene

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  1. Journal articles
  2. Dissertations / Theses

Academic literature on the topic 'Medicinal chemistry-Polystyrene'

Author: Grafiati
Published: 6 September 2023

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Journal articles on the topic "Medicinal chemistry-Polystyrene"

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Rokhum, Lalthazuala, and Ghanashyam Bez. "Recent Application of Polystyrene-supported Triphenylphosphine in Solid-Phase Organic Synthesis." Current Organic Chemistry 23, no. 6 (July 4, 2019): 643–78. http://dx.doi.org/10.2174/1385272822666181026115752.

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Recent years have witnessed a fast development of solid phase synthetic pathways, a variety of solid-supported reagent and its applications in diverse synthetic strategies and pharmaceutical applicability’s. Polymer-supported triphenylphosphine is getting a lot of applications owing to the speed and simplicity in the process. Furthermore, ease of recyclability and reuse of polymer-supported triphenylphosphine added its advantages. This review covers a wide range of useful organic transformations which are accomplished using cross-linked polystyrene-supported triphenylphosphine with the aim of giving renewed interest in the field of organic and medicinal-combinatorial chemistry.
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Carlton, Robert A., Edward Orton, Charles E. Lyman, and James E. Roberts. "Qualitative Analysis of Solid Phase Synthesis Reaction Products by X-ray Spectrometry." Microscopy and Microanalysis 3, no. 6 (November 1997): 520–29. http://dx.doi.org/10.1017/s1431927697970409.

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Abstract: A novel method for the synthesis of polypeptides using polystyrene/divinylbenzene copolymers as solid supports has drawn the attention of medicinal, pharmaceutical, and agricultural chemists because of its utility in combinatorial chemistry and parallel synthesis. In this method, arrays of solid-phase organic synthesis experiments are conducted simultaneously thereby enabling the preparation of large numbers of novel compounds over a short time period. The analysis of organic compounds attached to polymer supports presents unique challenges to chemists. This study presents some results of the application of energy-dispersive X-ray spectrometry (EDS) in the environmental scanning electron microscope (ESEM) to this problem. EDS in the ESEM has the advantages of minimal sample size, speed, and simplicity because the analyses are performed without special specimen preparation. The progress of a two-step synthetic transformation was followed using EDS-ESEM by the presence of a sulfur peak in the first synthetic step and by a bromine peak in the second step. The synthetic products were also evaluated by infrared spectroscopy and by elemental analysis (ion chromatography). The agreement of the qualitative analysis among all three techniques was good. Analysis by EDS-ESEM not only complements current analytical techniques in solid phase synthesis; it also provides insight into the details of the synthetic transformation.
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Li, Jin, Yajun Zheng, Wei Mi, Theoneste Muyizere, and Zhiping Zhang. "Polystyrene-impregnated paper substrates for direct mass spectrometric analysis of proteins and peptides in complex matrices." Analytical Methods 10, no. 24 (2018): 2803–11. http://dx.doi.org/10.1039/c8ay01081a.

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Li, Yandan, Miao Li, Zhen Li, Lei Yang, and Xiang Liu. "Effects of particle size and solution chemistry on Triclosan sorption on polystyrene microplastic." Chemosphere 231 (September 2019): 308–14. http://dx.doi.org/10.1016/j.chemosphere.2019.05.116.

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Krueger, Martin C., Bettina Seiwert, Andrea Prager, Shangwei Zhang, Bernd Abel, Hauke Harms, and Dietmar Schlosser. "Degradation of polystyrene and selected analogues by biological Fenton chemistry approaches: Opportunities and limitations." Chemosphere 173 (April 2017): 520–28. http://dx.doi.org/10.1016/j.chemosphere.2017.01.089.

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Li, Qiongfang, Bo Zhang, Naresh Kasoju, Jinmin Ma, Aidong Yang, Zhanfeng Cui, Hui Wang, and Hua Ye. "Differential and Interactive Effects of Substrate Topography and Chemistry on Human Mesenchymal Stem Cell Gene Expression." International Journal of Molecular Sciences 19, no. 8 (August 9, 2018): 2344. http://dx.doi.org/10.3390/ijms19082344.

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Variations in substrate chemistry and the micro-structure were shown to have a significant effect on the biology of human mesenchymal stromal cells (hMSCs). This occurs when differences in the surface properties indirectly modulate pathways within numerous signaling networks that control cell fate. To understand how the surface features affect hMSC gene expression, we performed RNA-sequencing analysis of bone marrow-derived hMSCs cultured on tissue culture-treated polystyrene (TCP) and poly(l-lactide) (PLLA) based substrates of differing topography (Fl: flat and Fs: fibrous) and chemistry (Pr: pristine and Am: aminated). Whilst 80% of gene expression remained similar for cells cultured on test substrates, the analysis of differentially expressed genes (DEGs) revealed that surface topography significantly altered gene expression more than surface chemistry. The Fl and Fs topologies introduced opposite directional alternations in gene expression when compared to TCP control. In addition, the effect of chemical treatment interacted with that of topography in a synergistic manner with the Pr samples promoting more DEGs than Am samples in all gene ontology function groups. These findings not only highlight the significance of the culture surface on regulating the overall gene expression profile but also provide novel insights into cell-material interactions that could help further design the next-generation biomaterials to facilitate hMSC applications. At the same time, further studies are required to investigate whether or not the observations noted correlate with subsequent protein expression and functionality of cells.
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Holdcroft, Steven, Ben-Zhong Tang, and James E. Guillet. "Two-photon chemistry: facile synthesis of naphthalene- and anthracene-labelled polystyrene by photolysis of aromatic esters." Journal of the Chemical Society, Chemical Communications, no. 5 (1991): 280. http://dx.doi.org/10.1039/c39910000280.

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Van, Bing. "The Properties of Resin Supports and Their Effects on Solid­ Phase Organic Synthesis." Combinatorial Chemistry & High Throughput Screening 1, no. 4 (December 1997): 215–29. http://dx.doi.org/10.2174/1386207301666220125213328.

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Solvated resin supports are important carriers for solid-phase organic synthesis in combinatorial chemistry and high-throughput parallel synthesis. The physical properties of resin, resin swelling and dynamic solvation, effects of solvated supports on synthesis, kinetics, site interaction, and product purity are reviewed. Selective solvation of resin alters the local reactivity and accessibility of the bound substrate and the mobility of the entrapped reagent. Resin solvation changes during the course of the reaction when the attached substrate changes its polarity or other physicochemical properties. Selective adsorption determines the reaction kinetics and the action of a phase-transfer catalyst further improves the reaction on resin. Sites interact with each other in 1% DVB polystyrene resins to varying degrees depending on solvent, resin, and reactivity of the pendant groups. Total site isolation seems only achievable by controlling several factors simultaneously such as lower loading and steric hindrance. Through the proper selection of resin and solvent, alternating solvents to accommodate dynamic solvation of the resin, optimization of kinetics when changing solid supports and a careful control of resin impurities, solid-phase organic synthesis can lead to high quality combinatorial libraries.
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Abdulkareem, Asma, Aya E. Abusrafa, Sifani Zavahir, Salma Habib, Patrik Sobolčiak, Marian Lehocky, Hana Pištěková, Petr Humpolíček, and Anton Popelka. "Novel Slippery Liquid-Infused Porous Surfaces (SLIPS) Based on Electrospun Polydimethylsiloxane/Polystyrene Fibrous Structures Infused with Natural Blackseed Oil." International Journal of Molecular Sciences 23, no. 7 (March 27, 2022): 3682. http://dx.doi.org/10.3390/ijms23073682.

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Hydrophobic fibrous slippery liquid-infused porous surfaces (SLIPS) were fabricated by electrospinning polydimethylsiloxane (PDMS) and polystyrene (PS) as a carrier polymer on plasma-treated polyethylene (PE) and polyurethane (PU) substrates. Subsequent infusion of blackseed oil (BSO) into the porous structures was applied for the preparation of the SLIPS. SLIPS with infused lubricants can act as a repellency layer and play an important role in the prevention of biofilm formation. The effect of polymer solutions used in the electrospinning process was investigated to obtain well-defined hydrophobic fibrous structures. The surface properties were analyzed through various optical, macroscopic and spectroscopic techniques. A comprehensive investigation of the surface chemistry, surface morphology/topography, and mechanical properties was carried out on selected samples at optimized conditions. The electrospun fibers prepared using a mixture of PDMS/PS in the ratio of 1:1:10 (g/g/mL) using tetrahydrofuran (THF) solvent showed the best results in terms of fiber uniformity. The subsequent infusion of BSO into the fabricated PDMS/PS fiber mats exhibited slippery behavior regarding water droplets. Moreover, prepared SLIPS exhibited antibacterial activity against Staphylococcus aureus and Escherichia coli bacterium strains.
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Vasil’eva, Irina, Olga Morozova, Galina Shumakovich, and Alexander Yaropolov. "Betaine-Based Deep Eutectic Solvent as a New Media for Laccase-Catalyzed Template-Guided Polymerization/Copolymerization of Aniline and 3-Aminobenzoic Acid." International Journal of Molecular Sciences 23, no. 19 (September 27, 2022): 11409. http://dx.doi.org/10.3390/ijms231911409.

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Deep eutectic solvents (DESs) can compensate for some of the major drawbacks of traditional organic solvents and ionic liquids and meet all requirements of green chemistry. However, the potential of their use as a medium for biocatalytic reactions has not been adequately studied. In this work we used the DES betaine-glycerol with a molar ratio of 1:2 as co-solvent for enzymatic template-guided polymerization/copolymerization of aniline (ANI) and 3-aminobenzoic acid (3ABA). The laccase from the basidial fungus Trametes hirsuta and air oxygen served as catalyst and oxidant, respectively. Sodium polystyrene sulfonate (PSS) was used as template. Interpolyelectrolyte complexes of homopolymers polyaniline (PANI) and poly(3-aminobenzoic acid) (P3ABA) and copolymer poly(aniline-co-3-aminobenzoic acid) (P(ANI-3ABA)) were prepared and their physico-chemical properties were studied by UV-Vis and FTIR spectroscopy and cyclic voltammetry. According to the results obtained by atomic force microscopy, PANI/PSS had a granular shape, P(ANI-3ABA)/PSS had a spherical shape and P3ABA/PSS had a spindle-like shape. The copolymer showed a greater antimicrobial activity against Escherichia coli and Staphylcocus aureus as compared with the homopolymers. The minimal inhibitory concentration of the P(ANI-3ABA)/PSS against the gram-positive bacterium S. aureus was 0.125 mg mL−1.
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Dissertations / Theses on the topic "Medicinal chemistry-Polystyrene"

1

Dalela, Manu. "Synthesis, characterization and biological evaluation of poly(styreneco-maleic anhydride) as a drug delivery vehicle for cancer therapy." Thesis, IIT Delhi, 2016. http://localhost:8080/xmlui/handle/12345678/7037.

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