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Journal articles on the topic 'Medication synchronization'

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Author: Grafiati
Published: 10 December 2022
Last updated: 28 January 2023

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1

Mu, Y., Y. Lou, A. Rozenbaum, and MS Taitel. "Medication Synchronization Improves Medication Adherence." Value in Health 21 (May 2018): S137. http://dx.doi.org/10.1016/j.jval.2018.04.921.

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2

Witry, Matthew, Melissa Ernzen, Anthony Pape, and Brahmendra Reddy Viyyuri. "Pilot and Feasibility of Combining a Medication Adherence Intervention and Group Diabetes Education for Patients with Type-2 Diabetes." Pharmacy 7, no. 3 (June 28, 2019): 76. http://dx.doi.org/10.3390/pharmacy7030076.

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Introduction: Controlling diabetes typically requires self-management and medications. Community pharmacists are positioned to support patients with both. Methods: This study assessed the feasibility and potential benefit of combining pharmacist-provided group diabetes education (up to eight sessions) and medication synchronization using a three-group design. Data were collected using pre–post paper surveys and electronic health record data. One group received both education and synchronization services, another group received medication synchronization only, and a third served as control. Results: Of 300 contacted patients, eighteen patients participated in group diabetes education, 14 had medication synchronization only, and 12 comprised a control group. There was little change in HbA1c over the study period. Medication adherence appeared to be positively aided by medication synchronization, although all groups started with high adherence. Some medication beliefs and self-care activities may have been positively impacted by group diabetes education. Both groups receiving medication synchronization were satisfied. Conclusions: Participants strongly agreed they would recommend group diabetes education from the study pharmacy to a friend and were satisfied with medication synchronization; however, it was difficult to tell if there was a synergistic effect by combining the two services. Reimbursement for diabetes education was not obtained despite multiple attempts, hindering sustainability.
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3

White, Nicole D. "Pharmacy Medication Synchronization Service Works to Improve Medication Adherence." American Journal of Lifestyle Medicine 10, no. 6 (July 26, 2016): 385–87. http://dx.doi.org/10.1177/1559827616660687.

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4

Krumme, Alexis A., Robert J. Glynn, Sebastian Schneeweiss, Joshua J. Gagne, J. Samantha Dougherty, Gregory Brill, and Niteesh K. Choudhry. "Medication Synchronization Programs Improve Adherence To Cardiovascular Medications And Health Care Use." Health Affairs 37, no. 1 (January 2018): 125–33. http://dx.doi.org/10.1377/hlthaff.2017.0881.

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5

Holdford, David, and Kunal Saxena. "Impact of Appointment-Based Medication Synchronization on Existing Users of Chronic Medications." Journal of Managed Care & Specialty Pharmacy 21, no. 8 (August 2015): 662–69. http://dx.doi.org/10.18553/jmcp.2015.21.8.662.

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6

Holdford, D. A., and K. Saxena. "Impact of appointment-based Medication Synchronization on existing users of Chronic Medications." Value in Health 18, no. 3 (May 2015): A260. http://dx.doi.org/10.1016/j.jval.2015.03.1513.

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7

Ghassemi, Emily, Jennifer Smith, Laura Owens, Charles Herring, and Melissa Holland. "Relationship between medication synchronization and antiretroviral adherence." Journal of the American Pharmacists Association 58, no. 4 (July 2018): S78—S82. http://dx.doi.org/10.1016/j.japh.2018.05.002.

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8

Phi, Catherine, Lucas A. Berenbrok, Joni C. Carroll, Ashley Firm, Melissa Somma McGivney, and Kim C. Coley. "Impact of a Medication Adherence Packaging Service on Patient-Centered Outcomes at an Independent Community Pharmacy." Pharmacy 9, no. 1 (January 5, 2021): 11. http://dx.doi.org/10.3390/pharmacy9010011.

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The purpose of this project was to evaluate the impact of a comprehensive medication adherence packaging (RxMAP) service on patient medication-taking behaviors and patient-centered outcomes. Adult patients who utilized a single independent community pharmacy, enrolled in the RxMAP service for at least two consecutive cycles, and managed their own medications were eligible. The RxMAP service consists of multi-dose blister packaging in 28-day cycles, medication synchronization, monthly touchpoint calls, and delivery/mailing. A 13-item telephonic survey was administered, and patients’ verbal responses were captured by audio-recording and detailed note taking. Descriptive statistics were used to quantify the results and illustrative quotes representing the interview domains were selected. There were 42 patients who completed the survey: 88% reported they missed fewer doses compared to before using RxMAP; 71% were more likely to take their medications on time each day; 86% were more confident with managing their medications; and 74% were more independent. Finally, 64% of patients stated their overall quality of life was better now compared to before using the packaging service. These results demonstrate that medication adherence packaging services can positively impact patients’ medication-taking behaviors, increase their confidence in medication management, and improve perceived quality of life.
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Adams, Alex J. "Medication synchronization: A regulatory approach to “short fills”." Journal of the American Pharmacists Association 57, no. 3 (May 2017): 299–300. http://dx.doi.org/10.1016/j.japh.2017.02.017.

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10

Dao, Nancy, Sun Lee, Micah Hata, and Lord Sarino. "Impact of Appointment-Based Medication Synchronization on Proportion of Days Covered for Chronic Medications." Pharmacy 6, no. 2 (May 22, 2018): 44. http://dx.doi.org/10.3390/pharmacy6020044.

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11

Ariyo, Olufunmi, Olivia Kinney, Andrea Brookhart, Pramit Nadpara, and Jean-Venable “Kelly” R. Goode. "Medication therapy problems and vaccine needs identified during initial appointment-based medication synchronization visits." Journal of the American Pharmacists Association 59, no. 4 (July 2019): S67—S71. http://dx.doi.org/10.1016/j.japh.2019.04.019.

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12

Koren, Or, Ronny P. Bartsch, Zoya Katzir, Uri Rosenblum, Sharon Hassin-Baer, Rivka Inzelberg, and Meir Plotnik. "Dopaminergic medication reduces interhemispheric hyper-synchronization in Parkinson's disease." Parkinsonism & Related Disorders 97 (April 2022): 39–46. http://dx.doi.org/10.1016/j.parkreldis.2022.02.009.

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13

Patti, Michael, Chelsea Renfro, and Stefanie Ferreri. "Identification of medication synchronization core components in community pharmacies." Research in Social and Administrative Pharmacy 14, no. 5 (May 2018): e2. http://dx.doi.org/10.1016/j.sapharm.2018.03.011.

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14

Patti, Michael, Chelsea Phillips Renfro, Rachael Posey, Gabrielle Wu, Kea Turner, and Stefanie P. Ferreri. "Systematic review of medication synchronization in community pharmacy practice." Research in Social and Administrative Pharmacy 15, no. 11 (November 2019): 1281–88. http://dx.doi.org/10.1016/j.sapharm.2018.11.008.

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15

Butler, Kendra T., Janelle F. Ruisinger, Jessica Bates, Emily S. Prohaska, and Brittany L. Melton. "Participant satisfaction with a community-based medication synchronization program." Journal of the American Pharmacists Association 55, no. 5 (September 2015): 534–39. http://dx.doi.org/10.1331/japha.2015.14242.

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16

Renfro, Chelsea Phillips, Michael Patti, Jordan M. Ballou, and Stefanie P. Ferreri. "Development of a medication synchronization common language for community pharmacies." Journal of the American Pharmacists Association 58, no. 5 (September 2018): 515–21. http://dx.doi.org/10.1016/j.japh.2018.04.032.

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17

Shope, Cori J., Matthew Bruno, Christine M. Ruby, John Naumovski, Carlo J. Iasella, and Monica Aspinall. "Evaluating the Effects of a Medication Adherence Packaging Program on Outcomes in Older People." Senior Care Pharmacist 37, no. 2 (February 1, 2022): 73–81. http://dx.doi.org/10.4140/tcp.n.2022.73.

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Objective To determine the impact of an adherence packaging and medication synchronization program on hospital visits for older people living independently in the community. Design A retrospective pre-post study that evaluated patient outcomes over a 24-month period was conducted. Patient-specific socio-demographic, medical, and hospital visit-related data were collected for 12 months before and after patient enrollment in the adherence packaging program. Setting The study was conducted at Rx Partners LTC, LLC, a University of Pittsburgh Medical Center (UPMC) pharmacy in Pittsburgh, Pennsylvania. Participants Patients 65 years of age or older, of any gender, with UPMC Health Plan insurance coverage, who enrolled in the adherence packaging program between July 2019 and December 2019. Intervention Enrollment in the adherence packaging program included medication synchronization and packaging in prefilled medication sets delivered to the patient’s home monthly. Monthly medication reconciliation and review by clinical pharmacists was an included value-added service. Results Of the 92 patients included in the analysis, 60 had hospital visits during their pre-enrollment period for a total of 146 visits, compared with 54 patients in the postenrollment period totaling 126 visits; however, the mean rate of hospital visits was not statistically significant (1.59 versus 1.37; P = 0.48). Pharmacists prevented 1.87 medication errors/patient in the postenrollment setting. Conclusion Enrollment in the program was associated with fewer hospital visits, though not statistically significant, and pharmacists had abundant opportunity to prevent medication errors and optimize regimens. Further evaluation is warranted in a larger cohort.
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18

Holdford, David A., and Timothy J. Inocencio. "Adherence and persistence associated with an appointment-based medication synchronization program." Journal of the American Pharmacists Association 53, no. 6 (November 2013): 576–83. http://dx.doi.org/10.1331/japha.2013.13082.

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19

Girdish, Charmaine, William Shrank, Sarah Freytag, David Chen, Doug Gebhard, Andrew Bunton, Niteesh Choudhry, and Jennifer Polinski. "The impact of a retail prescription synchronization program on medication adherence." Journal of the American Pharmacists Association 57, no. 5 (September 2017): 579–84. http://dx.doi.org/10.1016/j.japh.2017.05.016.

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20

Nguyen, E., and D. M. Sobieraj. "The impact of appointment-based medication synchronization on medication taking behaviour and health outcomes: A systematic review." Journal of Clinical Pharmacy and Therapeutics 42, no. 4 (May 8, 2017): 404–13. http://dx.doi.org/10.1111/jcpt.12554.

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21

Feng, L., Y. Mu, and M. Taitel. "PMU122 MEDICATION SYNCHRONIZATION IS ASSOCIATED WITH GREATER ADHERENCE AND LOWER HEALTHCARE EXPENDITURES." Value in Health 23 (May 2020): S256. http://dx.doi.org/10.1016/j.jval.2020.04.886.

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22

Miller, Andrew M., Svjetlana Miocinovic, Nicole C. Swann, Sheila S. Rajagopalan, David M. Darevsky, Ro’ee Gilron, Coralie de Hemptinne, Jill L. Ostrem, and Philip A. Starr. "Effect of levodopa on electroencephalographic biomarkers of the parkinsonian state." Journal of Neurophysiology 122, no. 1 (July 1, 2019): 290–99. http://dx.doi.org/10.1152/jn.00141.2019.

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The objective of this study was to evaluate proposed electroencephalographic (EEG) biomarkers of Parkinson’s disease (PD) and test their correlation with motor impairment in a new, well-characterized cohort of PD patients and controls. Sixty-four-channel EEG was recorded from 14 patients with rigid-akinetic PD with minimal tremor and from 14 age-matched healthy controls at rest and during voluntary movement. Patients were tested off and on medication during a single session. Recordings were analyzed for phase-amplitude coupling over sensorimotor cortex and for pairwise coherence from all electrode pairs in the recording montage (distributed coherence). Phase-amplitude coupling and distributed coherence were found to be elevated Off compared with On levodopa, and their reduction was correlated with motor improvement. In the Off medication state, phase-amplitude coupling was greater in sensorimotor contacts contralateral to the most affected body part and reduced by voluntary movement. We conclude that phase-amplitude coupling and distributed coherence are cortical biomarkers of the parkinsonian state that are detectable noninvasively and may be useful as objective aids for management of dopaminergic therapy. Several analytic methods may be used for noninvasive measurement of abnormal brain synchronization in PD. Calculation of phase-amplitude coupling requires only a single electrode over motor cortex. NEW & NOTEWORTHY Several EEG biomarkers of the parkinsonian state have been proposed that are related to abnormal cortical synchronization. We report several new findings in this study: correlations of EEG markers of synchronization with specific motor signs of Parkinson’s disease (PD), and demonstration that one of the EEG markers, phase-amplitude coupling, is more elevated over the more clinically affected brain hemisphere. These findings underscore the potential utility of scalp EEG for objective, noninvasive monitoring of medication state in PD.
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23

Chen, Hui-Chuan, and Edmund Prater. "Information System Costs of Utilizing Electronic Product Codes in Achieving Global Data Synchronization within the Pharmaceutical Supply Chain Network." International Journal of Information Systems and Supply Chain Management 6, no. 1 (January 2013): 62–76. http://dx.doi.org/10.4018/jisscm.2013010104.

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Numerous benefits of implementation of global data synchronization (GDSN) in the pharmaceutical supply chain have been identified, including reduced counterfeiting, decreased medication errors, increased supply chain efficiency, and standardized regulatory evolution. For this study, a complete GDSN supply chain framework was developed as a model for the industry to achieve Global Standard (GS1) standards. Each supply chain member must have a strong enterprise resource planning (ERP) information system to accommodate the initial electronic product code information services (EPCIS). A web-based Datapool—which connects the manufacturer, distributor, and retailer—will assist in reaching the data synchronization stage. The most important step is to have an open standard of GS1 global registry to enable the Epedigree to be traced through the supply chain system. When combined with EPCIS, as well as electronic product code global (EPCglobal) standardization and GS1 Global Registry, the supply chain can achieve global data synchronization and traceability. The comprehensive GDSN framework provided in this study provides the pharmaceutical industry an estimate of the total costs of attaining a global data synchronization network.
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24

Andrews, S. B., T. R. Marcy, B. Osborn, and L. G. Planas. "The impact of an appointment-based medication synchronization programme on chronic medication adherence in an adult community pharmacy population." Journal of Clinical Pharmacy and Therapeutics 42, no. 4 (April 24, 2017): 461–66. http://dx.doi.org/10.1111/jcpt.12533.

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25

Pattin, Anthony, Rebekah L. Panak, Rebecca Hunold, Abagail Kirwen, Samantha R. Minnich, and Tian Chen. "A Medication Synchronization Program and Blood Pressure Levels in a Community Pharmacy: Protocol." JMIR Research Protocols 8, no. 4 (April 1, 2019): e12527. http://dx.doi.org/10.2196/12527.

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26

Mu, Y., J. Zhang, C. John, and M. Taitel. "PNS50 MODELING THE ECONOMIC VALUE OF MEDICATION SYNCHRONIZATION AMONG COMMERCIAL AND MEDICAID POPULATIONS." Value in Health 22 (May 2019): S294—S295. http://dx.doi.org/10.1016/j.jval.2019.04.1931.

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27

Bernard, Kaitlyn, Brooke Cowles, Kenneth McCall, Rose Mary Henningsen, Moira O’Toole, and Chunhao Tu. "Impact of medication synchronization programs on proportion of days covered (PDC) scores and Medicare Part D medication-related adherence metrics." Journal of the American Pharmacists Association 59, no. 3 (May 2019): 343–48. http://dx.doi.org/10.1016/j.japh.2019.02.003.

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28

Coyle, Mark, Mark Wilkinson, and Mark Sheehy. "Otherwise Unexplained Transient QTc Prolongation in a Patient Admitted with COVID Disease." Case Reports in Cardiology 2021 (May 31, 2021): 1–5. http://dx.doi.org/10.1155/2021/9931405.

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Background. Several cardiovascular manifestations of coronavirus disease 2019 (COVID-19) have been previously described. QT prolongation has been reported in COVID-19 infection in association with medications such as azithromycin, hydroxychloroquine, and chloroquine but has not previously been reported as a direct result of COVID-19 infection. Case summary. We report the case of a 65-year-old female who developed a prolonged corrected QT interval (QTc) during a hospital admission with COVID-19. This patient was not on any QT prolonging treatment, serum electrolytes were normal, and there was no identifiable reversible cause for the QTc lengthening. Daily serial ECGs during admission showed resolution of the ventricular repolarization abnormality in synchronization with resolution of her COVID-19 viral illness. Discussions. Although there have been reports of QTc prolongation in COVID-19 patients, previous reports of this are for patients receiving medication that causes QT prolongation. This case uniquely demonstrates the development and resolution of this temporary ventricular repolarization abnormality in a patient with a structurally normal heart with no evidence of myocardial fibrosis or edema on cardiac MRI, that is unexplained by other confounding factors, such as medication. This suggests there may be a direct association between COVID-19 and temporary QTc prolongation.
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29

Renfro, Chelsea, Davis Coulter, Lan Ly, Cindy Fisher, Lindsay Cardosi, Mike Wasson, and Kenneth C. Hohmeier. "Exploring Pharmacy Technician Roles in the Implementation of an Appointment-Based Medication Synchronization Program." Pharmacy 8, no. 1 (March 3, 2020): 28. http://dx.doi.org/10.3390/pharmacy8010028.

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The objective of this study was to qualitatively explore the role of pharmacy technicians in the implementation of an appointment-based model (ABM) medication synchronization program. The purposeful sampling of technicians working within six different locations of a supermarket chain pharmacy in Mississippi and Tennessee was carried out, and the technicians were interviewed between January and April 2018. A semi-structured interview guide was developed based on the Consolidated Framework for Implementation Research (CFIR). Questions gathered information around pharmacy technician demographics and CFIR domains (process, inner setting, outer setting and intervention characteristics). Interviews were audiotaped and transcribed. Two members of the research team performed thematic content analysis. Six full-time, certified pharmacy technicians with 8.3 ± 2.7 years of experience were interviewed. Findings suggest that including hands-on experience with program software is needed during training to successfully implement ABM. A barrier to implementation was the time needed to complete ABM tasks as compared to other tasks. Although some barriers exist regarding implementation, technicians believe that overall, this program has positive benefits for patients. Results from this study signify that ABM implementation can be challenging. Better ABM portal integration with the pharmacy patient profile and appropriate workforce budgeting are key to continued success.
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30

Hinson, Jessica L., Gretchen K. Garofoli, and Betsy M. Elswick. "The impact of medication synchronization on quality care criteria in an independent community pharmacy." Journal of the American Pharmacists Association 57, no. 2 (March 2017): 236–40. http://dx.doi.org/10.1016/j.japh.2016.11.008.

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31

Salgado, Teresa M., Meagen M. Rosenthal, Antoinette B. Coe, Tana N. Kaefer, Dave L. Dixon, and Karen B. Farris. "Primary healthcare policy and vision for community pharmacy and pharmacists in the United States." Pharmacy Practice 18, no. 3 (September 18, 2020): 2160. http://dx.doi.org/10.18549/pharmpract.2020.3.2160.

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The United States (US) has a complex healthcare system with a mix of public, private, nonprofit, and for-profit insurers, healthcare institutions and organizations, and providers. Unlike other developed countries, there is not a single payer healthcare system or a national pharmaceutical benefits scheme/plan. Despite spending over USD 10,000 per capita in healthcare, the US is among the worst performers compared to other developed countries in outcomes including life expectancy at birth, infant mortality, safety during childbirth, and unmanaged chronic conditions (e.g., asthma, diabetes). Primary care is delivered by physicians and advanced practice providers (i.e., nurse practitioners and physician assistants) in a variety of settings including large health systems, federally qualified health centers or free clinics that provide care to the underserved, or specific facilities for veterans or American Indian and Alaska native peoples. Since 2010, primary care delivery has shifted toward providing patient-centered, coordinated, comprehensive care focused on providing proactive, rather than reactive, population health management, and on the quality, versus volume, of care. Community pharmacy comprises a mix of independently owned, chain, supermarket and mass merchant pharmacies. Community pharmacies provide services such as immunizations, medication therapy management, medication packaging, medication synchronization, point-of-care testing and, in specific states where legislation has been passed, hormonal contraception, opioid reversal agents, and smoking cessation services. There has been criticism regarding the lack of standard terminology for services such as medication synchronization and medication therapy management, their components and how they should be provided, which hampers comparability across studies. One of the main challenges for pharmacists in the US is the lack of provider status at the federal level. This means that pharmacists are not allowed to use existing fee-for-service health insurance billing codes to receive reimbursement for non-dispensing services. In addition, despite there being regulatory infrastructure in multiple states, the extent of service implementation is either low or unknown. Research found that pharmacists face numerous barriers when providing some of these services. State fragmentation and the lack of a single pharmacy organization and vision for the profession are additional challenges.
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32

Costello, Fiona, Lisa Kumor, and JoAnn Stubbings. "Medication synchronization service for patients with multiple myeloma within a health system–based specialty pharmacy." American Journal of Health-System Pharmacy 77, no. 24 (October 22, 2020): 2042–44. http://dx.doi.org/10.1093/ajhp/zxaa314.

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33

Bata, Zsófia, Enikő Vasziné Szabó, and Zsuzsanna Tóth. "A fogpótláskészítés szempontjai biszfoszfonáttal kezelt idős páciens esetén." Orvosi Hetilap 159, no. 48 (December 2018): 2031–36. http://dx.doi.org/10.1556/650.2018.31200.

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Abstract: Recently, drugs targeting the remodelling, vascular circulation and homeostasis of bone are frequently applied with an unquestionable benefit in the therapy of numerous severe medical conditions. Besides bisphosphonates, other antiresorptive and antiangiogenic drugs are also used, however, limited publications are focusing on data of their results. Increasing number of patients arrives the mentioned medication is increasing in the daily dental practice, especially when accurate anamnesis is taken. Our aim is to highlight the preventive considerations that help minimize the occurence of medication-related osteonecrosis of the jaw by presentating a complex dental rehabilitation of a patient at risk. The synchronization of dental surgery, conservative and prosthodontic treatment is essential in the case of an elderly patient having many concomitant disorders. Our aim is also to draw the attention of our colleagues working on different medical fields to the timing of dental procedures. The best and simplest way to prevent jaw necrosis is to achieve good oral health and hygiene before the introduction of antiresorptive therapy. If, however, our patient is already taking this medication, we still have a chance to prevent the appearance of this devastating condition by following the preventive measures. The medication-related necrosis of the jaw is a severe condition leading to a decreased life quality and having a reduced healing expectancy. Orv Hetil. 2018; 159(48): 2031–2036.
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34

Fitzpatrick, Rebecca M., Matthew J. Witry, William R. Doucette, Kelly Kent, Michael J. Deninger, Randal P. McDonough, and Stevie Veach. "Retrospective analysis of drug therapy problems identified with a telephonic appointment-based model of medication synchronization." Pharmacy Practice 17, no. 2 (June 30, 2019): 1373. http://dx.doi.org/10.18549/pharmpract.2019.2.1373.

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35

Witry, Matthew. "Appointment-Based Models and Medication Synchronization: Silver Bullet for Adherence or One Piece of the Puzzle?" Journal of Managed Care & Specialty Pharmacy 21, no. 8 (August 2015): 714. http://dx.doi.org/10.18553/jmcp.2015.21.8.714.

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36

Blackburn, David F., Charity Evans, Holly Mansell, Jeff Taylor, Derek Jorgenson, Kerry Mansell, Yvonne Shevchuk, Shirin Aladwan, Guangming Zhao, and Michael Wright. "Impact of the SIMPL-SYNC Refill Synchronization Program on medication adherence: A pragmatic randomized controlled trial." Journal of the American Pharmacists Association 60, no. 2 (March 2020): 328–35. http://dx.doi.org/10.1016/j.japh.2019.10.010.

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37

Steffens, David C., Lihong Wang, and Godfrey D. Pearlson. "Functional connectivity predictors of acute depression treatment outcome." International Psychogeriatrics 31, no. 12 (January 3, 2019): 1831–35. http://dx.doi.org/10.1017/s1041610218002260.

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ABSTRACTFew studies have examined functional connectivity (FC) patterns using functional magnetic resonance imaging (fMRI) to predict outcomes in late-life depression. We hypothesized that FC within and between frontal and limbic regions would be associated with 12-week depression outcome in older depressed adults. Seventy-one subjects with major depression were enrolled in the study. A study geriatric psychiatrist performed a clinical interview and completed a Montgomery-Åsberg Depression Rating Scale (MADRS). All study participants were free of medication at baseline and had a brain fMRI scan. Using a regions of interest (ROI) atlas (including 164 ROIs), we conducted ROI-to-ROI resting-state FC analyses for each participant. In terms of treatment participants were offered sertraline initially, although in this naturalistic study, other medications were also prescribed. Subjects were evaluated every 2 weeks up to 12 weeks by the study psychiatrist, who followed a flexible, clinically based medication dosing schedule. Multivariate regression analysis was used to examine correlation between change of MADRS score over 12 weeks and baseline FC between brain regions, controlling for age, gender, mean head motion, and baseline MADRS. We found greater FC between the left inferior frontal gyrus pars triangularis and the left frontal eye field and FC of these two regions with a number of brain regions related to reward, salience, and sensorimortor function were correlated with change in MADRS score over 12 weeks. Our results highlight the important role of between inner speech-reward, attention-salience, and attention-sensorimotor network synchronization in predicting acute treatment response in late-life depression.
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38

Waghmare, P., C. Y. Huang, W. M. Green, H. A. Jaynes, M. E. Snyder, and A. J. Zillich. "P70 Evaluation of Cost and Health Utilization Outcomes of Medicare Beneficiaries Enrolled in a Medication Synchronization Program." Value in Health 25, no. 7 (July 2022): S302. http://dx.doi.org/10.1016/j.jval.2022.04.090.

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39

Hughes, Tamera D., Stacey Cutrell, Lana M. Minshew, Patrick Brown, and Stefanie P. Ferreri. "An exploration of barriers, facilitators, and practical solutions for adopting medication synchronization into community pharmacies: A qualitative analysis." Exploratory Research in Clinical and Social Pharmacy 5 (March 2022): 100111. http://dx.doi.org/10.1016/j.rcsop.2022.100111.

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40

Huang, Chen, William Doucette, Michael Andreski, and Anthony Pudlo. "Patient Experiences at Enhanced-Service Pharmacies in Iowa." INNOVATIONS in pharmacy 10, no. 2 (May 22, 2019): 11. http://dx.doi.org/10.24926/iip.v10i2.1530.

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Objectives: As payment systems are evolving, the role of community pharmacists has expanded from simply dispensing prescriptions to actively providing care to patients. Little is known about patients’ experiences with enhanced pharmacy services under the pay-for-performance model. In Iowa, Wellmark implemented its Value-Based Pharmacy Program (VBPP) where pharmacists receive capitation for performance on a set of quality measurements. Therefore, the objective of this study was to evaluate the quality of services and pharmacies from patients’ perspective in VBPP. A structured interview guide developed from the service quality model was used for this study. Methods: We conducted telephone interviews with patients from 6 community pharmacies participating in VBPP between December 2017 and January 2018. Patients who were aged between 21 and 90 years, had Wellmark prescription drug coverage, were currently on at least three medications with one or more of the medications for a chronic condition and had received enhanced pharmacy services were invited for the study. The semi-structured interview transcripts were coded and analyzed using an inductive approach of thematic analysis. Results: Interviews were completed by 25 patients. Most of them were female and the average age was 59. More than half of the patients were taking at least five medications for chronic conditions. A majority of the patients received medication synchronization and immunization. A total of 13 themes across the service quality dimensions were identified. Patients thought their pharmacists were reliable, responsive, knowledgeable and trustworthy when they provided services. Pharmacy services were accessible and perceived as high quality. Privacy was not a big concern for most patients. Patients had a somewhat limited view regarding how pharmacists helped them maintain health. Conclusions: Patients’ perceptions of enhanced pharmacy services and pharmacies were generally positive while their understanding of pharmacists’ clinical role was limited. Article Type: Original Research
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41

Holiga, Štefan, Joerg F. Hipp, Christopher H. Chatham, Pilar Garces, Will Spooren, Xavier Liogier D’Ardhuy, Alessandro Bertolino, et al. "Patients with autism spectrum disorders display reproducible functional connectivity alterations." Science Translational Medicine 11, no. 481 (February 27, 2019): eaat9223. http://dx.doi.org/10.1126/scitranslmed.aat9223.

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Despite the high clinical burden, little is known about pathophysiology underlying autism spectrum disorder (ASD). Recent resting-state functional magnetic resonance imaging (rs-fMRI) studies have found atypical synchronization of brain activity in ASD. However, no consensus has been reached on the nature and clinical relevance of these alterations. Here, we addressed these questions in four large ASD cohorts. Using rs-fMRI, we identified functional connectivity alterations associated with ASD. We tested for associations of these imaging phenotypes with clinical and demographic factors such as age, sex, medication status, and clinical symptom severity. Our results showed reproducible patterns of ASD-associated functional hyper- and hypoconnectivity. Hypoconnectivity was primarily restricted to sensory-motor regions, whereas hyperconnectivity hubs were predominately located in prefrontal and parietal cortices. Shifts in cortico-cortical between-network connectivity from outside to within the identified regions were shown to be a key driver of these abnormalities. This reproducible pathophysiological phenotype was partially associated with core ASD symptoms related to communication and daily living skills and was not affected by age, sex, or medication status. Although the large effect sizes in standardized cohorts are encouraging with respect to potential application as a treatment and for patient stratification, the moderate link to clinical symptoms and the large overlap with healthy controls currently limit the usability of identified alterations as diagnostic or efficacy readout.
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42

Holdford, David A. "Using Service Blueprints to Visualize Pharmacy Innovations." Pharmacy 7, no. 2 (May 8, 2019): 43. http://dx.doi.org/10.3390/pharmacy7020043.

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Background: Applying the principles of service design can help pharmacists manage both the quality and patient perceptions of the services they provide. Service blueprints are a widely used service design tool that are rare in the healthcare literature. They can be used to design new services or revisit the design of established services. This paper describes service blueprints and their uses, and illustrates how to build one using an example. Methods: A blueprint is built for appointment-based medication synchronization services to illustrate the tool. Conclusions: Service blueprints permit pharmacists to better see and understand service processes. They clarify the process of service delivery and the roles of customers, service providers, and supporting services. They provide a way of depicting complex services in a concise visual way that communicates details at a glance. Pharmacists who utilize service blueprints can improve the consistency and quality of services provided, and they can increase the chance that every interaction with patients sends a positive message about the value of pharmacist services.
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43

Wigal, Sharon B., Chiara M. Polzonetti, Annamarie Stehli, and Enrico Gratton. "Phase synchronization of oxygenation waves in the frontal areas of children with attention-deficit hyperactivity disorder detected by optical diffusion spectroscopy correlates with medication." Journal of Biomedical Optics 17, no. 12 (December 11, 2012): 127002. http://dx.doi.org/10.1117/1.jbo.17.12.127002.

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44

Matthews, Megan E., Patricia Evangelista, and Tatyana Gurvich. "Geriatric Pharmacotherapy Case Series: Poly-Provider Leading to Polypharmacy." Senior Care Pharmacist 37, no. 10 (October 1, 2022): 499–509. http://dx.doi.org/10.4140/tcp.n.2022.499.

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Background: This case study reviews the complicated treatment of an older person under the care of numerous specialists in the ambulatory care setting. As various providers made concurrent changes in pharmacotherapy without communication with other providers, the patient experienced acute changes and decompensation. Assessment: Polypharmacy played a significant role in the acute decompensation of the patient. Changes made in the context of specific specialties inadvertently had a negative impact on other disease states. Outcome: Intentional communication between all providers on the patient’s health care team resulted in a deeper understanding of the overall plan and therapeutic goals. Care synchronization ultimately improved patient outcomes. The clinical pharmacy team provided multiple pharmacotherapy recommendations to improve pain and anxiety without jeopardizing safety and therapeutics for other disease states. These interventions provided a key element that streamlined and improved patient-centered care. Conclusion: In this case, poly-provider was responsible for polypharmacy that significantly impacted the patient’s care and quality of life. Pharmacists and the pharmacists’ patient care process play a significant role in improving patient-centered care by identifying medication changes and potential side effects, especially in the wake of interventions by multiple providers.
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45

Chong, Catherine D., Todd J. Schwedt, and Anders Hougaard. "Brain functional connectivity in headache disorders: A narrative review of MRI investigations." Journal of Cerebral Blood Flow & Metabolism 39, no. 4 (November 20, 2017): 650–69. http://dx.doi.org/10.1177/0271678x17740794.

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Resting-state functional magnetic resonance imaging (rs-fMRI) is used to interrogate the functional connectivity and network organization amongst brain regions. Functional connectivity is determined by measuring the extent of synchronization in the spontaneous fluctuations of blood oxygenation level dependent (BOLD) signal. Here, we review current rs-fMRI studies in headache disorders including migraine, trigeminal autonomic cephalalgias, and medication overuse headache. We discuss (1) brain network alterations that are shared amongst the different headache disorders and (2) network abnormalities distinct to each headache disorder. In order to focus the section on migraine, the headache disorder that has been most extensively studied, we chose to include articles that interrogated functional connectivity: (i) during the attack phase; (ii) in migraine patients with aura compared to migraine patients without aura; and (iii) of regions within limbic, sensory, motor, executive and default mode networks and those which participate in multisensory integration. The results of this review show that headache disorders are associated with atypical functional connectivity of regions associated with pain processing as well as atypical functional connectivity of multiple core resting state networks such as the salience, sensorimotor, executive, attention, limbic, visual, and default mode networks.
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46

Toth, Kaitlyn, and Dan Wilson. "Control of coupled neural oscillations using near-periodic inputs." Chaos: An Interdisciplinary Journal of Nonlinear Science 32, no. 3 (March 2022): 033130. http://dx.doi.org/10.1063/5.0076508.

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Deep brain stimulation (DBS) is a commonly used treatment for medication resistant Parkinson’s disease and is an emerging treatment for other neurological disorders. More recently, phase-specific adaptive DBS (aDBS), whereby the application of stimulation is locked to a particular phase of tremor, has been proposed as a strategy to improve therapeutic efficacy and decrease side effects. In this work, in the context of these phase-specific aDBS strategies, we investigate the dynamical behavior of large populations of coupled neurons in response to near-periodic stimulation, namely, stimulation that is periodic except for a slowly changing amplitude and phase offset that can be used to coordinate the timing of applied input with a specified phase of model oscillations. Using an adaptive phase-amplitude reduction strategy, we illustrate that for a large population of oscillatory neurons, the temporal evolution of the associated phase distribution in response to near-periodic forcing can be captured using a reduced order model with four state variables. Subsequently, we devise and validate a closed-loop control strategy to disrupt synchronization caused by coupling. Additionally, we identify strategies for implementing the proposed control strategy in situations where underlying model equations are unavailable by estimating the necessary terms of the reduced order equations in real-time from observables.
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47

Jolley, Benjamin, and Theresa Prosser. "A tale of two pharmacies: The impact on adherence of a medication synchronization program implementation in an urban traditional retail pharmacy and in a specialty pharmacy." Research in Social and Administrative Pharmacy 13, no. 4 (July 2017): e18-e19. http://dx.doi.org/10.1016/j.sapharm.2017.03.013.

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48

Abdulkadhim, Fahad Ghalib, Zhang Yi, and Mudassar Khalid. "SMART PHARMACY MONITORING SYSTEM BASED ON MQTT PROTOCOL USING RFID AND RASPBERRY PI." EUREKA: Physics and Engineering 2 (March 31, 2020): 98–104. http://dx.doi.org/10.21303/2461-4262.2020.001207.

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Smart mobile pharmacy has become a necessary requirement in improving the quality of healthy life in the last five years. Determining the type of medication and calculating the dose for each patient according to the patient's condition, monitoring the patient at the post and how to take the doses on time have a great effect on improving the patient's condition as soon as possible. In this paper, a system of monitoring, monitoring, and guidance based on potency management have been designed to contain a cloud data storage platform and its implementation to solve the above problem. The system is achieved by connecting each item (Medicine bottle) to a device (RFID) to verify that the patient has arrived in the bottle the correct medicine and is equipped with suppression of the treatment of the drug contains the sensors of weight to be sent all information to the control unit to be over the Internet through the routing portal. All data is stored in the first two data folders, which are static and the second is mobile. Synchronization between the two stations is performed to update the information and will be executed on a server that uses an MQTT protocol to register and integrate messages on the platform. The results of the experiment show the speed of guidance and reduce cost and reduce energy.
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Belardinelli, Paolo, Ramin Azodi-Avval, Erick Ortiz, Georgios Naros, Florian Grimm, Daniel Weiss, and Alireza Gharabaghi. "Intraoperative localization of spatially and spectrally distinct resting-state networks in Parkinson’s disease." Journal of Neurosurgery 132, no. 4 (April 2020): 1234–42. http://dx.doi.org/10.3171/2018.11.jns181684.

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Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for symptomatic Parkinson’s disease (PD); the clinical benefit may not only mirror modulation of local STN activity but also reflect consecutive network effects on cortical oscillatory activity. Moreover, STN-DBS selectively suppresses spatially and spectrally distinct patterns of synchronous oscillatory activity within cortical-subcortical loops. These STN-cortical circuits have been described in PD patients using magnetoencephalography after surgery. This network information, however, is currently not available during surgery to inform the implantation strategy.The authors recorded spontaneous brain activity in 3 awake patients with PD (mean age 67 ± 14 years; mean disease duration 13 ± 7 years) during implantation of DBS electrodes into the STN after overnight withdrawal of dopaminergic medication. Intraoperative propofol was discontinued at least 30 minutes prior to the electrophysiological recordings. The authors used a novel approach for performing simultaneous recordings of STN local field potentials (LFPs) and multichannel electroencephalography (EEG) at rest. Coherent oscillations between LFP and EEG sensors were computed, and subsequent dynamic imaging of coherent sources was performed.The authors identified coherent activity in the upper beta range (21–35 Hz) between the STN and the ipsilateral mesial (pre)motor area. Coherence in the theta range (4–6 Hz) was detected in the ipsilateral prefrontal area.These findings demonstrate the feasibility of detecting frequency-specific and spatially distinct synchronization between the STN and cortex during DBS surgery. Mapping the STN with this technique may disentangle different functional loops relevant for refined targeting during DBS implantation.
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Mohd Rafi, Muhamad Firdaus, Arief Ruhullah A Harris, Tan Tian Swee, Kah Meng Leong, Jia Hou Tan, Kelvin Ling Chia Hiik, Tengku Ahmad Iskandar Tengku Alang, et al. "Brain-computer interface algorithm based on wavelet-phase stability analysis in motor imagery experiment." Malaysian Journal of Fundamental and Applied Sciences 16, no. 2 (April 15, 2020): 236–42. http://dx.doi.org/10.11113/mjfas.v16n2.1119.

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Severe movement or motor disability diseases such as amyotrophic lateral sclerosis (ALS), cerebral palsy (CB), and muscular dystrophy (MD) are types of diseases which lead to the total of function loss of body parts, usually limbs. Patient with an extreme motor impairment might suffers a locked-in state, resulting in the difficulty to perform any physical movements. These diseases are commonly being treated by a specific rehabilitation procedure with prescribed medication. However, the recovery process is time-consuming through such treatments. To overcome these issues, Brain-Computer Interface system is introduced in which one of its modalities is to translate thought via electroencephalography (EEG) signals by the user and generating desired output directly to an external artificial control device or human augmentation. Here, phase synchronization is implemented to complement the BCI system by analyzing the phase stability between two input signals. The motor imagery-based experiment involved ten healthy subjects aged from 24 to 30 years old with balanced numbers between male and female. Two aforementioned input signals are the respective reference data and the real time data were measured by using phase stability technique by indicating values range from 0 (least stable) to 1 (most stable). Prior to that, feature extraction was utilized by applying continuous wavelet transform (CWT) to quantify significant features on the basis of motor imagery experiment which are right and left imaginations. The technique was able to segregate different classes of motor imagery task based on classification accuracy. This study affirmed the approach’s ability to achieve high accuracy output measurements.
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