Dissertations / Theses on the topic 'Medical displays'
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Dawood, Richard M. "New technology in radiological diagnosis : an investigation of diagnostic image quality in digital displays of radiographs." Thesis, University College London (University of London), 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289055.
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Momenipour, Amirmasoud. "Audio-tactile displays to improve learnability and perceived urgency of alarming stimuli." Diss., University of Iowa, 2019. https://ir.uiowa.edu/etd/6993.
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Based on cross-modal learning and multiple resources theory, human performance can be improved by receiving and processing additional streams of information from the environment. In alarm situations, alarm meanings need to be distinguishable from each other and learnable for users. In audible alarms, by manipulating the temporal characteristics of sounds different audible signals can be generated. However, in some cases such as in using discrete medical alarms, when there are too many audible signals to manage, changes in temporal characteristics may not generate discriminable signals that would be easy for listeners to learn. Multimodal displays can be developed to generate additional auditory, visual, and tactile stimuli for helping humans benefit from cross-modal learning and multiple attentional resources for a better understanding of the alarm situations. In designing multimodal alarm displays in work domains where the alarms are predominantly auditory-based and where accessing visual displays is not possible at all times, tactile displays can enhance the effectiveness of alarms by providing additional streams of information for understanding the alarms. However, because of low information density of tactile information presentation, the use of tactile alarms has been limited. In this thesis, by using human subjects, the learnability of auditory and tactile alarms, separately and together in an audio-tactile display were studied. The objective of the study was to test cross-modal learning when messages of an alarm (i.e. meaning, urgency level) were conveyed simultaneously in audible, tactile and audio-tactile alarm displays. The alarm signals were designed by using spatial characteristics of tactile, and temporal characteristics of audible signals separately in audible and tactile displays as well as together in an audio-tactile display. This study explored if using multimodal alarms (tactile and audible) would help learning unimodal (audible or tactile) alarm meanings and urgency levels. The findings of this study can help for design of more efficient discrete audio-tactile alarms that promote learnability of alarm meanings and urgency levels.
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Winterbottom, Marc. "Individual Differences in the Use of Remote Vision Stereoscopic Displays." Wright State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=wright1433453135.
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Koelemeijer, Dorien. "The Design and Evaluation of Ambient Displays in a Hospital Environment." Thesis, Malmö högskola, Fakulteten för kultur och samhälle (KS), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-23601.
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Hospital environments are ranked as one of the most stressful contemporary work environments for their employees, and this especially concerns nurses (Nejati et al. 2016). One of the core problems comprises the notion that the current technology adopted in hospitals does not support the mobile nature of medical work and the complex work environment, in which people and information are distributed (Bardram 2003). The employment of inadequate technology and the strenuous access to information results in a decrease in efficiency regarding the fulfilment of medical tasks, and puts a strain on the attention of the medical personnel. This thesis proposes a solution to the aforementioned problems through the design of ambient displays, that inform the medical personnel with the health statuses of patients whilst requiring minimal allocation of attention. The ambient displays concede a hierarchy of information, where the most essential information encompasses an overview of patients’ vital signs. Data regarding the vital signs are measured by biometric sensors and are embodied by shape-changing interfaces, of which the ambient displays consist. User-authentication permits the medical personnel to access a deeper layer within the hierarchy of information, entailing clinical data such as patient EMRs, after gesture-based interaction with the ambient display. The additional clinical information is retrieved on the user’s PDA, and can subsequently be viewed in more detail, or modified at any place within the hospital.In this thesis, prototypes of shape-changing interfaces were designed and evaluated in a hospital environment. The evaluation was focused on the interaction design and user-experience of the shape-changing interface, the capabilities of the ambient displays to inform users through peripheral awareness, as well as the remote communication between patient and healthcare professional through biometric data. The evaluations indicated that the required attention allocated for the acquisition of information from the shape-changing interface was minimal. The interaction with the ambient display, as well as with the PDA when accessing additional clinical data, was deemed intuitive, yet comprised a short learning curve. Furthermore, the evaluations in situ pointed out that for optimised communication through the ambient displays, an overview of the health statuses of approximately eight patients should be displayed, and placed in the corridors of the hospital ward.
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McIntire, John Paul. "Investigating the Relationship between Binocular Disparity, Viewer Discomfort, and Depth Task Performance on Stereoscopic 3D Displays." Wright State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=wright1400790668.
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Berberich, Katelyn. "Evaluating Mobile Information Display System in Transfer of Care." Wright State University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=wright1503437044573349.
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Guarnieri, Gabriele. "High dynamic range images: processing, display and perceptual quality assessment." Doctoral thesis, Università degli studi di Trieste, 2009. http://hdl.handle.net/10077/3121.
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2007/2008The intensity of natural light can span over 10 orders of magnitude from starlight to direct sunlight. Even in a single scene, the luminance of the bright areas can be thousands or millions of times greater than the luminance in the dark areas; the ratio between the maximum and the minimum luminance values is commonly known as dynamic range or contrast. The human visual system is able to operate in an extremely wide range of luminance conditions without saturation and at the same time it can perceive fine details which involve small luminance differences. Our eyes achieve this ability by modulating their response as a function of the local mean luminance with a process known as local adaptation. In particular, the visual sensation is not linked to the absolute luminance, but rather to its spatial and temporal variation. One consequence of the local adaptation capability of the eye is that the objects in a scene maintain their appearance even if the light source illuminating the scene changes significantly. On the other hand, the technologies used for the acquisition and reproduction of digital images are able to handle correctly a significantly smaller luminance range of 2 to 3 orders of magnitude at most. Therefore, a high dynamic range (HDR) image poses several challenges and requires the use of appropriate techniques. These elementary observations define the context in which the entire research work described in this Thesis has been performed. As indicated below, different fields have been considered; they range from the acquisition of HDR images to their display, from visual quality evaluation to medical applications, and include some developments on a recently proposed class of display equipment. An HDR image can be captured by taking multiple photographs with different exposure times or by using high dynamic range sensors; moreover, synthetic HDR images can be generated with computer graphics by means of physically-based algorithms which often involve advanced lighting simulations. An HDR image, although acquired correctly, can not be displayed on a conventional monitor. The white level of most devices is limited to a few hundred cd/m² by technological constraints, primarily linked to the power consumption and heat dissipation; the black level also has a non negligible luminance, in particular for devices based on the liquid crystal technology. However, thanks to the aforementioned properties of the human visual system, an exact reproduction of the luminance in the original scene is not strictly necessary in order to produce a similar sensation in the observer. For this purpose, dynamic range reduction algorithms have been developed which attenuate the large luminance variations in an image while preserving as far as possible the fine details. The most simple dynamic range reduction algorithms map each pixel individually with the same nonlinear function commonly known as tone mapping curve. One operator we propose, based on a modified logarithmic function, has a low computational cost and contains one single user-adjustable parameter. However, the methods belonging to this category can reduce the visibility of the details in some portions of the image. More advanced methods also take into account the pixel neighborhood. This approach can achieve a better preservation of the details, but the loss of one-to-one mapping from input luminances to display values can lead to the formation of gradient reversal effects, which typically appear as halos around the object boundaries. Different solutions to this problem have been attempted. One method we introduce is able to avoid the formation of halos and intrinsically prevents any clipping of the output display values. The method is formulated as a constrained optimization problem, which is solved efficiently by means of appropriate numerical methods. In specific applications, such as the medical one, the use of dynamic range reduction algorithms is discouraged because any artifacts introduced by the processing can lead to an incorrect diagnosis. In particular, a one-to-one mapping from the physical data (for instance, a tissue density in radiographic techniques) to the display value is often an essential requirement. For this purpose, high dynamic range displays, capable of reproducing images with a wide luminance range and possibly a higher bit depth, are under active development. Dual layer LCD displays, for instance, use two liquid crystal panels stacked one on top of the other over an enhanced backlight unit in order to achieve a dynamic range of 4 ÷ 5 orders of magnitude. The grayscale reproduction accuracy is also increased, although a “bit depth” can not be defined unambiguously because the luminance levels obtained by the combination of the two panels are partially overlapped and unevenly spaced. A dual layer LCD display, however, requires the use of complex splitting algorithms in order to generate the two images which drive the two liquid crystal panels. A splitting algorithm should compensate multiple sources of error, including the parallax introduced by the viewing angle, the gray-level clipping introduced by the limited dynamic range of the panels, the visibility of the reconstruction error, and glare effects introduced by an unwanted light scattering between the two panels. For these reasons, complex constrained optimization techniques are necessary. We propose an objective function which incorporates all the desired constraints and requirements and can be minimized efficiently by means of appropriate techniques based on multigrid methods. The quality assessment of high dynamic range images requires the development of appropriate techniques. By their own nature, dynamic range reduction algorithms change the luminance values of an image significantly and make most image fidelity metrics inapplicable. Some particular aspects of the methods can be quantified by means of appropriate operators; for instance, we introduce an expression which describes the detail attenuation introduced by a tone mapping curve. In general, a subjective quality assessment is preferably performed by means of appropriate psychophysical experiments. We conducted a set of experiments, targeted specifically at measuring the level of agreement between different users when adjusting the parameter of the modified logarithmic mapping method we propose. The experimental results show a strong correlation between the user-adjusted parameter and the image statistics, and suggest a simple technique for the automatic adjustment of this parameter. On the other hand, the quality assessment in the medical field is preferably performed by means of objective methods. In particular, task-based quality measures evaluate by means of appropriate observer studies the clinical validity of the image used to perform a specific diagnostic task. We conducted a set of observer studies following this approach, targeted specifically at measuring the clinical benefit introduced by a high dynamic range display based on the dual layer LCD technology over a conventional display with a low dynamic range and 8-bit quantization. Observer studies are often time consuming and difficult to organize; in order to increase the number of tests, the human observers can be partially replaced by appropriate software applications, known as model observers or computational observers, which simulate the diagnostic task by means of statistical classification techniques. This thesis is structured as follows. Chapter 1 contains a brief background of concepts related to the physiology of human vision and to the electronic reproduction of images. The description we make is by no means complete and is only intended to introduce some concepts which will be extensively used in the following. Chapter 2 describes the technique of high dynamic range image acquisition by means of multiple exposures. In Chapter 3 we introduce the dynamic range reduction algorithms, providing an overview of the state of the art and proposing some improvements and novel techniques. In Chapter 4 we address the topic of quality assessment in dynamic range reduction algorithms; in particular, we introduce an operator which describes the detail attenuation introduced by tone mapping curves and describe a set of psychophysical experiments we conducted for the adjustment of the parameter in the modified logarithmic mapping method we propose. In Chapter 5 we move to the topic of medical images and describe the techniques used to map the density data of radiographic images to display luminances. We point out some limitations of the current technical recommendation and propose an improvement. In Chapter 6 we describe in detail the dual layer LCD prototype and propose different splitting algorithms for the generation of the two images which drive the two liquid crystal panels. In Chapter 7 we propose one possible technique for the estimation of the equivalent bit depth of a dual layer LCD display, based on a statistical analysis of the quantization noise. Finally, in Chapter 8 we address the topic of objective quality assessment in medical images and describe a set of observer studies we conducted in order to quantify the clinical benefit introduced by a high dynamic range display. No general conclusions are offered; the breadth of the subjects has suggested to draw more focused comments at the end of the individual chapters.
XXI Ciclo
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Plesniak, Wendy J. (Wendy Jean). "Volumetric rendering for holographic display of medical data." Thesis, Massachusetts Institute of Technology, 1988. http://hdl.handle.net/1721.1/63193.
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Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Architecture, 1988.Includes bibliographical references.
Work funded by a joint IBM/MIT agreement.
by Wendy J. Plesniak.
M.S.
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Moura, Lincoln de Assis. "A system for the reconstruction, handling and display of three-dimensional medical structures." Thesis, Imperial College London, 1988. http://hdl.handle.net/10044/1/47192.
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Fisher, Henry Donald 1943. "DESIGN OF REVIEW CONSOLE FOR RADIOLOGY APPLICATIONS (DISPLAY, PACS)." Thesis, The University of Arizona, 1986. http://hdl.handle.net/10150/291634.
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Asplund, Raquel. "Evaluation of a cloud-based image analysis and image display system for medical images." Thesis, Umeå universitet, Institutionen för tillämpad fysik och elektronik, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-105984.
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Fan, Jiahua. "Development of Image Display-Specific Evaluation and Optimization Schemes." Diss., The University of Arizona, 2006. http://hdl.handle.net/10150/195754.
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An electronic display is typically the last stage of an imaging chain before the human observer. Some of its physical properties can make it a bottleneck in the chain. This dissertation is an attempt to study and cope with certain critical properties of electronic displays, specifically spatial resolution, noise and contrast. The focus of this study lies in two parts. One is the measurement and estimation of display properties, including the spatial resolution and the spatial noise. The other is on the development of display-based image processing algorithms, which can compensate for the degradations from the specific display. The basic idea is to perform operations on the digital image before it is displayed, which will counteract the degradations that come from the action of the display systems. The properties of the display will be derived mainly from the digital images taken by a high quality CCD camera on the display. Based on the display properties estimated, several image processing techniques have been developed in this project to optimize the spatial resolution, noise and contrast resolution of the specific display under consideration. We have also developed a novel error-diffusion-based algorithm for adaptive image contrast enhancement which incorporates the properties of the display as well as the properties of the image.
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Wang, Yu. "Mechanistic study of aryl hydrocarbon receptor nuclear translocator (ARNT)-mediated signaling." Scholarly Commons, 2013. https://scholarlycommons.pacific.edu/uop_etds/151.
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A novel aryl hydrocarbon receptor nuclear translocator (ARNT)-interacting peptide (Ainpl) was characterized from human liver cDNA library using phage display. Ainpl suppresses hypoxia inducible factor-1a (HIF-1α) signaling pathway through an ARNTdependent manner. HIF-1α is known to be overexpressed in more than 90% of solid tumors, and the inhibition of HIF-1α is proved as an effective approach to suppress tumor growth. ARNT, as the obligatory heterodimeric partner of HIF-1α for downstream gene activation, was used as a bait to screen for Ainpl. Ainpl specifically interacts with the helix-loop-helix (HLH) subdomain of ARNT, but not with HIF-1α. GFP-Ainpl is localized in both cytoplasm and nucleus, and suppresses HIF-1α signaling by two mechanisms: (1) cytoplasmic GFP-Ainp 1 retains ARNT in the cell cytoplasm and (2) nuclear GFP-Ainpl inhibits HIF-1α/ARNT heterodimerization. The suppression of Ainpl on HIF-1α signaling was reversed by introducing ARNT into the cells using transient transfection. We further utilized HIV TAT protein transduction domain to deliver 6His-TAT-Ainpl into three different cancer cell lines (Hep3B, HeLa, MCF-7), and found that 6His-TAT-Ainpl co-localizes with ARNT in the cell nucleus. 6His-TATAinpl can be detected inside the cells after 30 min of transduction, and can reach the maximum level at 2 h. 6His-TAT-Ainp 1 remained detectable in the cells up to 96 h and had a half life of 24 h after transduction. In addition, 6His-TAT-Ainp 1 suppresses HIF-1α downstream genes at both message and protein levels in a dose-dependent manner. Taken together, molecules that target the HIF-1α and ARNT interface can be developed as viable drugs to suppress HIF-1α signaling.
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Lei, Xin. "Analyzing “Design + Medical” Collaboration Using Participatory Action Research (PAR): A Case Study of the Oxygen Saturation Data Display Project at Cincinnati Children’s Hospital Medical Center." University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1427983695.
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Birnstock, Jan. "Siebdruck von Displays auf Basis konjugierter Polymere /." Aachen : Shaker, 2003. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=010465063&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.
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Black, David Verfasser], Horst [Akademischer Betreuer] Hahn, Jürgen [Gutachter] Schönwälder, Andreas [Gutachter] Nüchter, and Jörn [Gutachter] [Loviscach. "Auditory Display for Image-Guided Medical Interventions / David Black ; Gutachter: Jürgen Schönwälder, Andreas Nüchter, Jörn Loviscach ; Betreuer: Horst Hahn." Bremen : IRC-Library, Information Resource Center der Jacobs University Bremen, 2019. http://d-nb.info/1182033687/34.
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Snape, Julia. "Medieval art on display, 1750-2010." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/medieval-art-on-display-17502010(9e0b3b30-1d52-412d-862a-b655757307b1).html.
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This thesis asks how the curatorial framing of medieval objects - the processes of selection, classification, display and interpretation - affect how medieval objects are made legible within the museum. It investigates how different collectors and curators have deployed medieval objects over a period of two hundred and fifty years of museological practice. Throughout this history, medieval objects have been appropriated within a range of museological narratives that have positioned them variously as objects of curiosity, utility, scientific analysis, nationalistic interest and as sites of scholarly and popular attention. My purpose is to inquire how the epistemological re-positioning of objects is articulated through their presentation within the framework of the collection, museum or temporary exhibition and to question how the mechanics of display facilitate particular readings of medieval objects. I then consider how certain curatorial approaches may produce unintended effects that render the medieval object illegible or problematic in unexpected ways. I also acknowledge that unforeseen exhibitionary outcomes may not be solely due to the effects of curatorial intervention but may be wrought by the agency of objects themselves. This thesis therefore examines medieval objects as active participants that play a crucial role in influencing the communication of curatorial objectives and in affecting how they may be apprehended through exhibitionary practice. The thesis examines sixteen chronologically presented case studies, beginning in the mid eighteenth century and concluding in the early twenty-first century, that represent important or influential episodes in the history of the display of medieval art. It traces a selective history of the various ways medieval objects have been culturally positioned at particular points in time to reveal how curatorial techniques have worked to reinforce or undermine the perception of medieval objects as carriers of specific meanings. Through the examination of historical approaches to the display of medieval objects I reveal how familiar tropes of display, such as the use of specific lighting techniques and stained glass have characterized the museological staging of medieval objects and how these have endured into the twenty-first century. Drawing on performance theory, material culture theory and sensory theory I identify how the biographical histories, material characteristics and sensory properties of medieval objects have been re-activated or suppressed by curators to encourage audiences to engage with them in specific ways. This theoretical approach reveals a previously unacknowledged sensory cultural history of engagement with the medieval object and highlights how historical approaches that have privileged embodied engagement with objects continue to inform contemporary museological practice. I also draw on Actor-Network theory to illuminate how medieval objects may be understood as active agents within the chain of correspondences that links people, objects and exhibitions at particular points throughout this history. In this way I delineate an exhibitionary landscape through which we can understand medieval objects as multi-authored and polysemic entities but principally as the products of exhibitionary practice.
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Andersson, Ken G. "Combinatorial Protein Engineering Of Affibody Molecules Using E. Coli Display And Rational Design Of Affibody-Based Tracers For Medical Imaging." Doctoral thesis, KTH, Proteinteknologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-213451.
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Directed evolution is today an established strategy for generation of new affinity proteins. This thesis describes the development of a cell-display method using Escherichia coli for directed evolution of Affibody molecules. Further, the thesis describes rational design of Affibody-based tracers, intended for future patient stratification using medical imaging. Fusing recombinant proteins to various autotransporters is a promising approach for efficient surface display on the surface of E. coli, as well as for construction of high-complexity libraries. In paper I, we successfully engineered an expression vector for display of Affibody molecules using the autotransporter AIDA-I. In paper II, a large Affibody library of 2.3x109 variants was constructed and screening using FACS resulted in new specific binders in the nanomolar range. In paper III, we demonstrated Sortase-mediated secretion and conjugation of binders directly from the E. coli surface. The three following studies describe rational design of Affibody-based tracers against two cancer-associated targets for molecular imaging. First, anti-HER3 Affibody molecules were labelled with 111In, and SPECT imaging showed that the conjugates specifically targeted HER3-expressing xenografts. Furthermore, labeling with 68Ga for PET imaging showed that tumor uptake correlated with HER3 expression, suggesting that the tracers have potential for patient stratification. The last study describes the development and investigation of anti-EGFR Affibody-based imaging agents. Labeled with 89Zr, the Affibody tracer demonstrated higher tumor uptake at 3 h post injection than the anti-EGFR antibody cetuximab at 48 h post injection. In conclusion, this thesis describes new tools and knowledge that will hopefully contribute to the development of affinity proteins for biotechnology, therapy and medical imaging in the future.QC 20170904
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Stenstrom, Joyce E. "Effects of cinematic factors on the perception of wrist postures when viewed on a video display." Thesis, This resource online, 1991. http://scholar.lib.vt.edu/theses/available/etd-03022010-020204/.
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Kang, Robin. "Heart frontal section and hypertrophic cardiomyopathy /." Online version of thesis, 2010. http://hdl.handle.net/1850/11651.
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Rehm, Kelly. "Development and image quality assessment of a contrast-enhancement algorithm for display of digital chest radiographs." Diss., The University of Arizona, 1992. http://hdl.handle.net/10150/185844.
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This dissertation presents a contrast-enhancement algorithm called Artifact-Suppressed Adaptive Histogram Equalization (ASAHE). This algorithm was developed as part of a larger effort to replace the film radiographs currently used in radiology departments with digital images. Among the expected benefits of digital radiology are improved image management and greater diagnostic accuracy. Film radiographs record X-ray transmission data at high spatial resolution, and a wide dynamic range of signal. Current digital radiography systems record an image at reduced spatial resolution and with coarse sampling of the available dynamic range. These reductions have a negative impact on diagnostic accuracy. The contrast-enhancement algorithm presented in this dissertation is designed to boost diagnostic accuracy of radiologists using digital images. The ASAHE algorithm is an extension of an earlier technique called Adaptive Histogram Equalization (AHE). The AHE algorithm is unsuitable for chest radiographs because it over-enhances noise, and introduces boundary artifacts. The modifications incorporated in ASAHE suppress the artifacts and allow processing of chest radiographs. This dissertation describes the psychophysical methods used to evaluate the effects of processing algorithms on human observer performance. An experiment conducted with anthropomorphic phantoms and simulated nodules showed the ASAHE algorithm to be superior for human detection of nodules when compared to a computed radiography system's algorithm that is in current use. An experiment conducted using clinical images demonstrating pneumothoraces (partial lung collapse) indicated no difference in human observer accuracy when ASAHE images were compared to computed radiography images, but greater ease of diagnosis when ASAHE images were used. These results provide evidence to suggest that Artifact-Suppressed Adaptive Histogram Equalization can be effective in increasing diagnostic accuracy and efficiency.
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Germishuizen, Juanita. "Does the private health care sector display oligopolistic characteristics in South Africa?" Thesis, Stellenbosch : University of Stellenbosch, 2009. http://hdl.handle.net/10019.1/996.
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Thesis (MBA (Business Management))--University of Stellenbosch, 2009.ENGLISH ABSTRACT: In the field of Economics, the term “competition” refers to the method involved in steering an increase in supply, which leads to a decrease in equilibrium price and an increase in equilibrium quantity. However, competition involves more than just an increase in supply. In any economy, competition can affect factors, such as innovation, efficiency and the accessibility to goods and services. In some cases, the effect might not be positive, if the goods and services only benefit certain parties involved, rather than the general population. Traditionally, there are four basic types of market structure, with each structure displaying unique market power characteristics, which are initiated by an organisation’s profit motives. All market structures, other than that of perfect competition, are forms of imperfect competition. One such imperfect market structure is oligopoly, which has certain unique characteristics (Doyle, 2005:198). In the private health care sector, cost increases can be related to the increased market concentration, due to the increase of market power by hospital groups. Therefore, the prevalence of competition in the private health care sector should be monitored. That health care functions in a dynamic environment has been historically proven and can also be seen in the latest trends. A bundle of factors, rather than a single factor, determines success. Any overview of the international health care industry should demonstrate the rapid development of the industry. The industry, compared with the relatively elementary and experimental health care system of a few decades ago, is currently super specialised. A shift has taken place in the market from the role of the industry as a government-funded health care provider to that of a private hospital provider. In South Africa, the complexity of the health care sector is made even more complex by the many role-players and the interaction between the different private and public health providers. The cost of access to hospitals should be prioritised. Research shows that the private health care sector caters for the health needs of almost seven million people, who comprise only 15% of the total population. However, the sector has spent more money than the entire public sector, with the per capita expenditure exceeding that of the public sector eightfold. The increase in the cost of private hospitals in South Africa has been caused by changes in the market concentration. Such expenditure has given the private hospitals greater market power and has influenced their behaviour.
AFRIKAANSE OPSOMMING: In ekonomie verwys die term “kompetisie” na die metode betrokke om ’n toename in aanbod te veroorsaak, wat weer ’n verlaging in die ewewigsprys en ’n verhoging in die ewewigshoeveelheid tot gevolg het. Kompetisie behels egter meer as net ’n verhoging in aanbod. In enige ekonomie kan kompetisie faktore soos innovasie, doeltreffendheid en toegang tot goedere en dienste beïnvloed. In sommige gevalle is die effek egter nie positief nie, soos wanneer goedere en dienste slegs sekere belanghebbendes bevoordeel in plaas van die algemene publiek. Daar is, tradisioneel gesproke, vier basiese markstrukture wat elkeen unieke markbeherende eienskappe toon wat deur die organisasie se winsmotiewe geïnisieer word. Alle markstrukture, behalwe volmaakte kompetisie, is vorms van onvolmaakte kompetisie. Een so ’n markstruktuur is oligopolie wat sekere unieke eienskappe toon. In die privaat–gesondheidsorgsektor, is kosteverhogings gekoppel aan verhoogde markkonsentrasie as gevolg van die toename in privaat hospitaalgroepe. Kompetisie in die privaat-gesondheidsorgsektor moet dus gemonitor word. Dat gesondheidsorg in ’n dinamiese omgewing funksioneer is reeds bewys en kan ook in die nuutste tendense gesien word. Dit is egter ‘n hele groep faktore, nie slegs een faktor nie, wat sukses waarborg. ’n Oorsig van die internasionale gesondheidsorgindustrie toon dat ontwikkelinge in die industrie baie vinnig vorder. Vandag is gesondheidsorg uiters gespesialiseerd in vergelyking met dekades terug, toe dit relatief elementêr en eksperimenteel was. Die rol van die industrie het verskuif van ’n staats-gesubsidieerde diens na waar dit vandag grootliks deur privaat instansies gelewer word. In Suid-Afrika word ’n reeds komplekse gesondheidsorgsektor meer gekompliseer deur die baie rolspelers in die sektor asook die interaksie tussen die verskillende privaat- en staatsgesondheidsorgvoorsieners. Die koste van toegang tot hospitale behoort ’n prioriteit te wees. Navorsing toon dat die die privaatgesondheidsorgsektor dienste aan sewe miljoen mense bied wat slegs 15% van die totale populasie is. Hierdie sektor spandeer egter baie meer as die met ’n per capita uitgawe byna agt keer meer as staatsgesondheidsorg. Die oorsaak van koste verhogings in privaatgesondheidsorg in Suid-Afrikaanse hospitale is veroorsaak deur veranderinge in die konsentrasie van die privaatgesondheidsorgsektor. Dit gee privaathospitale groter markmag en beïnvloed dus hul optrede.
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Vercillo, Richard 1953. "Very high resolution video display memory and base image memory for a radiologic image analysis console." Thesis, The University of Arizona, 1988. http://hdl.handle.net/10150/276707.
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Digital radiographic images are created by a variety of diagnostic imaging modalities. A multi-modality workstation, known as the Arizona Viewing Console (AVC), was designed and built by the University of Arizona Radiology Department to support research in radiographic image processing and image display. Two specially designed VMEbus components, the base image memory and the video display memory, were integrated into the AVC and are the subject of this thesis. The base image memory is a multi-ported, 8 megabyte memory array based on random access memory used for raw image storage. It supports a 10 megapixel per second image processor and can interface to a 320 megabit per second network. The video display memory utilizes video memories and is capable of displaying two independent high resolution images, each 1024 pixels by 1536 lines, on separate video monitors. In part, these two memory designs have allowed the AVC to excel as a radiographic image workstation.
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Filipovic, Nedim. "Phage display to identify functional resistance mutations to Rigosertib." Scholarship @ Claremont, 2017. http://scholarship.claremont.edu/cmc_theses/1475.
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In vitro protein selection has had major impacts in the field of protein engineering. Traditional screens assay individual proteins for specific function. Selection, however, analyzes a pool of mutants and yields the best variants. Phage display, a successful selection technique, also provides a reliable link between variant phenotype and genotype. It can also be coupled with high throughput sequencing to map protein mutations; potentially highlighting vital mutations in variants. We propose to apply this technique to cancer therapy. RAF, a serine/threonine kinase, is critical for cell regulation in mammals. RAF can be activated by oncogenic RAS, found in over 30% of cancers, to drive cancer proliferation. Rigosertib, a benzyl styryl sulfone in phase III clinical trials for myelodysplastic syndrome (MDS), is an inhibitor of the RAS binding domain (RBD) in RAF. Phage display can be used to select RAF mutants for RAS binding affinity, in the presence of Rigosertib. High-throughput sequencing of these variants can provide a means of anticipating, and mapping resistance to this anti-cancer drug.
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ZIPPILLI, Lorenza. "Epitope mapping of a mAb against the factor H binding protein (fHbp) of N. meningitidis by phage display." Doctoral thesis, Università degli studi del Molise, 2012. http://hdl.handle.net/11695/66305.
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Attualmente non è ancora disponibile alcun vaccino ampiamente totalmente efficace per la prevenzione della meningite di gruppo B. Uno dei più promettenti candidati per lo sviluppo di un vaccino è la proteina che lega il fattore H (factor H-binding protein o fHbp), una lipoproteina di superficie espressa in tutti i ceppi di Neisseria meningitidis. La sua funzione è quella di legare il fattore H (fH), una molecola chiave della via alternativa della cascata del complemento. Il patogeno, legando sulla sua superficie il fH, riesce a bloccare l'attivazione del complemento e ad eludere le difese immunitarie dell'ospite. La fHbp è una componente di un nuovo vaccino per la protezione nei confronti della malattia meningococcica di gruppo B, che si trova attualmente nell'ultima fase di sperimentazione clinica.
In base alla variabilità nella composizione amminoacidica, la fHbp è stata suddivisa in tre diverse
varianti o due sottofamiglie e la sua architettura è modulare, costituita da 5 segmenti di residui variabili. Immunizzando topi con ciascuna delle 3 varianti della fHbp è stato prodotto un pannello di anticorpi monoclonali anti-fHbp. Gli epitopi riconosciuti da questi mAbs sono stati mappati tramite l'allineamento multiplo delle sequenze proteiche ed esperimenti di mutagenesi sito-specifica. Tuttavia questi approcci non hanno permesso di mappare l'epitopo di uno di questi mAb, denominato JAR 36.
L'anticorpo JAR 36 è stato prodotto immunizzando un topo con la fHbp nella variante 3, inoltre esso cross-reagisce con la proteina della variante 2 e mostra attività battericida cooperativa con JAR 11 e JAR 13.
E' stato effettuato uno screening di librerie di peptidi esposti sulla superficie di batteriofagi filamentosi allo scopo di identificare ì residui che costituiscono l'epitopo di JAR 36. Le ipotesi di mappatura sono state quindi verificate attraverso esperimenti di mutagenesi sito-specifica.
Inoltre, utilizzando un approccio computazionale, sono stati individuati 17 residui che potrebbero essere importanti per il riconoscimento della proteina da parte dell'Ab. In particolare 8 di questi residui risiedono in una regione ritenuta essere fondamentale per il riconoscimento di JAR 36 e 4 di essi sono comuni alle varianti 2 e 3.
Sia ì residui individuati usando la tecnologia del phage display che quelli predetti dall'analisi “in silico”, si trovano in prossimità del sito di legame del fH. Questi risultati possono sono in accordo con precedenti dati sperimentali in cui JAR 36 inibisce parzialmente il legame del fH.
I dati ottenuti contribuiranno alla caratterizzazione del meccanismo molecolare dell'immuno-protezione contro MenB, per lo sviluppo di vaccini a base proteica sempre più sicuri ed efficaci per la prevenzione dalla malattia causata da questo patogeno.No broadly protective vaccine is yet available for the prevention of group B meningococcal disease. One promising vaccine lead is the factor H binding protein (fHbp), a surface-exposed lipoprotein, which is present in all strains of Neisseria meningitidis. This protein binds human factor H (fH), contributing to the ability of these bacteria to avoid complement-mediated killing. The fHbp is a component of a serogroup B meningococcal vaccine currently in late-phase clinical development. Based on the sequence variability of the entire protein, fHbp has been divided into 3 variant groups or 2 sub-families and its architecture is modular, consisting of 5 variable segments, amino acid residues in position between 100 and 255 have been identified as important targets of variant-specific bactericidal antibodies. A panel of anti-fHbp mAbs has been produced from mice immunized with each of the 3 variants of fHbp and all their epitopes have been mapped, except that of the mAb designated JAR 36. This antibody was isolated from a mouse immunized with fHbp of the antigenic variant 3 group, but it cross-reacts with all fHbp sequences in the variant 2 group and elicits complement-mediated cooperative bactericidal activity with JAR 13 and JAR 11. We have screened phage displayed random peptide libraries to identify amino acid residues composing the JAR 36 epitope, putative mapping hypotheses have been then validated by constructing recombinant fHbps single-point variants through site-specific mutagenesis, and analyzing their reactivity with the mAb. Moreover, by using a computational tool, a total of seventeen residues have been identified as possibly constituting the epitope of JAR 36. Eight of these residues are located in a segment of fHbp previously recognized to play an important role in the binding of JAR 36 and four of them are common in variant groups 2 and 3. Both the amino acid identified by phage display and the “in silico”-predicted epitope are located in the proximity of the fH-binding site. This finding is according with previous experimental data, of JAR 36 partially inhibiting binding of fH to fHbp. The data reported will help in characterizing the molecular mechanism of immune protection against MenB, toward the development of safer and effective protein-based vaccines for the prevention of group B meningitis.
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Ek, Moira. "Bacterial Display of a Tau-Binding Affibody Construct:Towards Affinity Maturation." Thesis, KTH, Skolan för kemi, bioteknologi och hälsa (CBH), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-278580.
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Aggregation of microtubule-associated protein tau is involved in the pathology of several neurodegenerative diseases, including Alzheimer’s disease. The affibody TP4 has been shown to inhibit this aggregation process, and its target-binding positions were previously grafted onto a dimeric affibody scaffold, creating the sequestrin seqTP4. This project constitutes a part of the affinity maturation process of seqTP4, using two different bacterial display methods. An error-prone PCR library was first expressed on Staphylococcus carnosus cells for selection of variants with improved tau-binding properties, resulting in a library of 1.4×107 transformants. Flow cytometric tests indicated difficulties in the setup due to nonspecific interactions, and whereas several different approaches to alleviate the problems were investigated, two cell sorting attempts were ultimately unsuccessful. Subcloning of seqTP4 and the library to an Escherichia coli surface display vector resulted in functional surface expression of seqTP4 on E. coli JK321 and BL21 cells, and a BL21 library size of 1.6×109 transformants. An initial flow cytometric test of this library indicates the presence of improved tau-binding variants, paving the way for future cell sorting.Aggregering av mikrotubuli-associerat protein tau är involverad i patologin av flera neurodegenerativa sjukdomar, däribland Alzheimers sjukdom. Affibodymolekylen TP4 har visat sig inhibera denna aggregeringsprocess, och överföring av dess målbindande positioner till ett dimeriskt affibodyprotein har tidigare gett upphov till seqTP4, en så kallad sequestrin. Detta projekt utgör ett led i processen att affinitetsmaturera seqTP4, med hjälp av två olika metoder för presentation av proteiner på ytan av bakterieceller. Ett error-prone PCR-bibliotek uttrycktes först på ytan av Staphylococcus carnosus-celler för selektion av varianter med ökad affinitet för tau, vilket resulterade i ett bibliotek av 1.4×107 transformanter. Flödescytometriska tester tydde på svårigheter i detta upplägg på grund av ospecifika interaktioner, och emedan flera olika angreppssätt för att förmildra dessa problem undersöktes, misslyckades slutligen två cellsorteringsförsök. Omkloning av seqTP4 och biblioteket till en vektor för ytpresentation på Escherichia coli resulterade i funktionellt ytuttryck av seqTP4 på E. coli JK321- och BL21-celler, och ett BL21-bibliotek bestående av 1.6×109 transformanter. Ett första flödescytometriskt test av detta bibliotek tyder på närvaron av varianter med förbättrad förmåga att binda tau, och vägen ligger nu relativt öppen för cellsortering.
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McEwen, Timothy Ryan. "Development and Evaluation of an Ecological Display for the Detection, Evaluation, and Treatment of Cardiovascular Risk." Wright State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=wright1386593713.
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Kaiser, Jochen. "Verwendung stereoskopischer Informationsdarstellung in durchsichtfähigen Anzeigen am Beispiel eines Head-Up Displays /." Stuttgart : Ergonomia Verl, 2004. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=015474744&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.
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Huang, Li-Chieh. "Development of a novel bead display technology to identify protein ligands : application to identification of viral entry inhibitors and T-cell epitopes." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:7ca21487-7e7d-4552-8e16-65ec181c7bcc.
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With the continued need for drug discovery and the quest to understand disease and treatment, there remains a requirement for improved methods to study protein-protein interactions and to identify potential drug leads for protein targets. We sought to develop a new approach to directly link genotype and phenotype to use as a probe for the identification of binding partners of proteins. The method creates millions of water-in-oil emulsions, each of which functions as a micro-environment for the amplification of a library of random peptide-encoding DNA molecules, which covalently bind to a bead. Subsequently the emulsions are broken and the bead-DNA complexes are recovered, which subsequently form another emulsion with in vitro transcription and translation components and incubated under suitable protein synthesis conditions. The synthetic peptide is designed with tags that link to the same bead which it is translated from. In chapter 3, the detailed design and optimisation of the method will be discussed. Cross-clade neutralising antibodies specific to HIV-1 are rare, partly because glycosylation restricts access to conserved backbone residues of gp120. In chapter 4, we hypothesized that peptides may have greater access than relatively large antibody structures, and so used our method to display random peptides on beads using a protein domain scaffold. Using a single round of selection, we identified 22 gp120-binding peptides, 4 of which were able to inhibit HIV-1 replication in vitro. One of the inhibitory peptides was found to bind the CCR5/CXCR4-binding site of gp120 and was able to inhibit clade B and C CCR5-tropic isolates of HIV-1. We have identified HIV-1 cross-clade neutralising peptides using a novel in vitro bead display library. Comprehensive antigenic characterization of a T cell population of unknown specificity is challenging. Existing MHC class I expression systems are limited by the practical difficulty of probing cell populations with an MHC class I peptide library and the cross-reactivity of T cells that are able to recognise many variants of an index peptide. We reasoned that a bead-based display high-throughput approach may overcome these challenges. Using emulsion PCR and emulsion in vitro transcription/translation of a random library of peptides conjugated to β-2-microglobulin on beads, we refolded with exogenous wild-type HLA-A*0201 or CD8-null A*0201 (domains 1 and 2 of HLA-A*0201 and domain 3 of Kb with mutated residues 226A/227L). The HLA bead libraries were used to probe HLA-A*0201-restricted T cells with specificity for influenza, CMV and EBV. High-throughput sequencing was used to rank sequences of identified peptides. Compared to pre-selection sequences, we observed significant enrichment for sequences containing HLA-A2 anchors and correct viral fragments for all T cell populations. HLA bead display provides a novel approach to identify the specificity of T cells. In summary, we combine the convenient handling of beads, the homogeneity of micro-environment in emulsion, and next-generation sequencing to create an attractive alternative to identify ligands of protein targets and antigenic peptides.
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Ruiz, Altisent Marc. "Advanced illumination and view-selection techniques for volume rendering and its application to medical imaging." Doctoral thesis, Universitat de Girona, 2012. http://hdl.handle.net/10803/371154.
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Volume visualization is a method of extracting information from volumetric data using interactive graphics. Volume visualization aims to assist visual interpretation of data by creating three-dimensional models that reproduce real objects with sufficient detail and speed to support interactive manipulation. Illustrative rendering enhances the perception of features in a volume.
Volume rendering has two major goals: to obtain high quality images in real time, and to determine how to explore volume datasets in an effective way.
In this thesis we advance in these two lines. We propose several methods to approximate global illumination with low computational cost, permitting realistic and illustrative rendering. We also present a method to automatically define transfer functions given a target distribution. In addition, we introduce a method to automatize the creation of exploded views. Finally, we explore techniques to select the best viewpoints for a volume. Several of our contributions are based on information theory.La visualització de volums és un mètode per extreure informació de dades volumètriques mitjançant imatges interactives. L’objectiu és assistir la interpretació visual de dades creant models tridimensionals que reprodueixen objectes reals amb suficient detall i velocitat per permetre’n la manipulació interactivament. La visualització il·lustrativa millora la percepció de les característiques d'un volum. La visualització de volums té dos objectius principals: obtenir imatges d’alta qualitat en temps real, i determinar com explorar volums d'una manera efectiva. En aquesta tesi avancem en aquestes dues línies. Proposem diversos mètodes per aproximar la il·luminació global amb baix cost computacional, permetent la visualització realista i il·lustrativa. També presentem un mètode per definir automàticament funcions de transferència donada una distribució objectiu. A més, presentem un mètode per automatitzar la creació d’exploded views. Finalment, explorem tècniques per seleccionar els millors punts de vista d’un volum. Diverses de les contribucions estan basades en la teoria de la informació.
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Sulaiman, Lanre Precieux Kabir. "Seleção de motivos semelhantes a Papilomavírus, a partir de bibliotecas de phage display, que apresentem potencial aplicação translacional." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/5/5155/tde-29012018-133017/.
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O vínculo entre papilomavírus humano de alto risco e câncer cervical está bem estabelecido. Apesar da existência de vacinas profiláticas contra infecções pelos tipos mais comuns de HPV, para infecções e tumores causados por esses vírus as alternativas terapêuticas são restritas. Encontramos alguns motivos com homologias para proteínas do HPV de alto risco durante o imunoscreening de uma biblioteca de phage display com soros de participantes HPV-16-soropositivos da coorte Ludwig-McGill. Após enriquecimento das sequências, os bacteriófagos recombinantes foram purificados e amplificados para uso como imunógenos.Usando uma abordagem profilática, nós vacinamos experimentalmente camundongos imunocompetentes com um dos nossos bacteriófagos recombinantes, usando o bacteriófago sem inserto como controle. Estes camundongos foram então desafiados com células tumorais TC-1 (HPV-16 positivas), tendo-se avaliado as respostas imunes disparadas durante a progressão tumoral. Também usamos uma abordagem terapêutica, aonde os camundongos foram primeiro injetados com as células tumorais e imunizados com o bacteriófago após o estabelecimento do tumor. O crescimento tumoral foi monitorado e os tumores, baço e linfonodos foram avaliados quanto à quantidade e qualidade da resposta imunológica. Os testes de ELISA revelaram que todos os camundongos vacinados responderam à imunização com os diferentes bacteriófagos. O crescimento tumoral foi significativamente reduzido nas imunizações profiláticas e terapêuticas, embora a redução do tumor fosse mínima quando os camundongos foram tratados 9 dias após o enxerto. A redução no crescimento tumoral também se traduziu em uma sobrevivência significativamente maior para os camundongos imunizados. Estudos de infiltração celular não revelaram alterações em diversas sub-populações imunes, mas uma tendência de aumento de linfócitos T citotóxicos foi observada nos camundongos imunizados com PEP1 (bacteriófago contendo inserto). A importância deste aumento de CD8 na redução observada do crescimento tumoral foi confirmada utilizando camundongos CD8-knockout, onde a redução do crescimento tumoral previamente observada foi anulada. Foi observado um aumento de taxa CD8:CD4 nos camundongos imunizados e isto é uma indicação de ambiente tumoral citotóxico. Os ensaios de proliferação celular para testar a especificidade do antígeno dos linfócitos dos camundongos imunizados foram, no entanto, inconclusivos; da mesma forma, não pudemos alterar o padrão observado com o uso de adjuvante CpG. A utilidade da técnica de phage display também foi observada neste trabalho experimental. Trabalhos adicionais para entender o mecanismo de ação desses fagos recombinantes no controle do crescimento de tumores causados por HPV e seu potencial imuno-estimulador são necessáriosThe link between high-risk human papillomavirus and cervical cancer is well established. Despite the existence of prophylactic vaccines against infections by the most common types of HPV, therapeutic alternatives are limited for infections and tumors caused by these viruses. We found some homology motifs for high-risk HPV proteins during the immune-panning of a phage display library with sera from HPV-16- seropositive participants of the Ludwig-McGill cohort. After enrichment of the sequences, the recombinant bacteriophages were purified and amplified for use as immunogens. Using a prophylactic approach, we vaccinated experimentally immunocompetent mice with one of our recombinant bacteriophages using the insertless bacteriophage as a control. These mice were then challenged with TC-1 tumor cells (HPV-16 positive), and the immune responses triggered during tumor progression were evaluated. We also used a therapeutic approach where mice were first injected with tumor cells and immunized with the bacteriophage after tumor establishment. Tumor growth was monitored and tumors, spleen and lymph nodes were evaluated for the quantity and quality of the immune response. ELISA tests revealed that all vaccinated mice responded to immunization with the different bacteriophages. Tumor growth was significantly reduced in prophylactic and therapeutic immunizations, although tumor reduction was minimal when mice were treated 9 days after TC-1 cells grafting. The reduction in tumor growth also translated into a significantly greater survival for the immunized mice. Cell infiltration studies did not reveal changes in several immune subpopulations, but an upward trend in cytotoxic T lymphocytes was observed in mice immunized with PEP1 (insert-containing bacteriophage). The importance of this increase in CD8 in the observed reduction of tumor growth was confirmed using CD8-knockout mice, where the previously observed reduction of tumor growth was abolished. An increase in CD8:CD4 rate was observed in the immunized mice and this is an indication of a cytotoxic tumor environment. Cell proliferation assays to test the antigen specificity of lymphocytes from immunized mice were, however, inconclusive; likewise, we could not change the pattern observed with the use of CpG adjuvant. The usefulness of the phage display technique was also observed in this experimental work. Additional studies to understand the mechanism of action of these recombinant phages in the control of HPV tumor growth and its immunostimulatory potential are warranted
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Röstin, Martin. "Development of a Flexible Software Framework for Biosignal PI : An Open-Source Biosignal Acquisition and Processing System." Thesis, KTH, Skolan för teknik och hälsa (STH), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-183525.
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As the world population ages, the healthcare system is facing new challenges in treating more patients at a lower cost than today. One trend in addressing this problem is to increase the opportunities of in-home care. To achieve this there is a need for safe and cost-effective monitoring systems. Biosignal PI is an ongoing open-source project created to develop a flexible and affordable platform for development of stand-alone devices able to measure and process physiological signals. This master thesis project, performed at the department of Medical Sensors, Signals and System at the School of Technology and Health, aimed at further develop the Biosignal PI software by constructing a new flexible software framework architecture that could be used for measurement and processing of different types of biosignals. The project also aimed at implementing features for Heart Rate Variability(HRV) Analysis in the Biosignal PI software as well as developing a graphical user interface(GUI) for the Raspberry PI hardware module PiFace Control and Display. The project developed a new flexible abstract software framework for the Biosignal PI. The new framework was constructed to abstract all hardware specifics into smaller interchangeable modules, with the idea of the modules being independent in handling their specific task making it possible to make changes in the Biosignal PI software without having to rewrite all of the core. The new developed Biosignal PI software framework was implemented into the existing hardware setup consisting of an Raspberry PI, a small and affordable single-board computer, connected to ADAS1000, a low power analog front end capable of recording an Electrocardiography(ECG). To control the Biosignal PI software two different GUIs were implemented. One GUI extending the original software GUI with the added feature of making it able to perform HRV-Analysis on the Raspberry PI. This GUI requires a mouse and computer screen to function. To be able to control the Biosignal PI without mouse the project also created a GUI for the PiFace Control and Display. The PiFace GUI enables the user to collect and store ECG signals without the need of an big computer screen, increasing the mobility of the Biosignal PI device. To help with the development process and also to make the project more compliant with the Medical Device Directive a couple of development tools were implemented such as a CMake build system, integrating the project with the Googletest testing framework for automated testing and the implementation of the document generator software Doxygen to be able to create an Software Documentation. The Biosignal PI software developed in this thesis is available through Github at https://github.com/biosignalpi/Version-A1-Rapsberry-PIAllt eftersom världens befolkning åldras, ställs sjukvården inför nya utmaningar i att behandla fler patienter till en lägre kostnad än idag. En trend för att lösa detta problem är att utöka möjligheterna till vård i hemmet.För att kunna göra detta finns det ett ökande behov av säkra och kostnadseffektiva patientövervakningssystem. Biosignal PI är ett pågående projekt med öppen källkod som skapats för att utveckla en flexibel och prisvärd plattform för utveckling av fristående enheter som kan mäta och bearbeta olika fysiologiska signaler. Detta examensarbete genomfördes vid institutionen för medicinska sensorer, signaler och system vid Skolan för Teknik och Hälsa. Projektet syftade till att vidareutveckla den befintliga mjukvaran för Biosignal PI genom att skapa ett nytt flexibelt mjukvaruramverk som kan användas för mätning och bearbetning av olika typer av biosignaler.Projektet syftade också till att utvidga mjukvaran och lägga till funktioner för att kunna genomföra hjärtfrekvensvariabilitets(HRV) analys i Biosignal PIs mjukvara, samt att utveckla ett grafiskt användargränssnitt(GUI) för hårdvarumodulen PiFace Control and Display. Projektet har utvecklat ett nytt flexibelt mjukvaruramverk för Biosignal PI. Det nya ramverket konstruerades för att abstrahera alla hårdvaruspecifika delar in i mindre utbytbara moduler, med tanken att modulerna ska vara oberoende i hur de hanterar sin specifika uppgift. På så sätt ska det vara möjligt att göra ändringar i Biosignal PIs programvara utan att behöva skriva om hela mjukvaran.Det nyutvecklade Biosignal PI ramverket implementerades i det befintliga hårdvaru systemet, som består av en Raspberry PI, liten och prisvärd enkortsdator, ansluten till ADAS1000, en analog hårdvarumodul med möjlighet att registrera ett elektrokardiografi(EKG/ECG). För att kontrollera Biosignal PI programmet har två olika grafiska användargränssnitt skapats.Det ena gränssnitt är en utvidgning av original programvaran med tillagd funktionalitet för att kunna göra HRV-Analys på Raspberry PI, detta gränssnitt kräver dock mus och dataskärm för att kunna användas.För att kunna styra Biosignal PI utan mus och skärm skapades det även ett gränssnitt för PiFace Control and Display. PiFace gränssnittet gör det möjligt för användaren att samla in och lagra EKG-signaler utan att behöva en stor datorskärm, på så sätt kan man öka Biosignal PI systemets mobilitet. För att underlätta utvecklingsprocessen, samt göra projektet mer förenligt med det medicintekniska regelverket, har ett par utvecklingsverktyg integrerats till Biosignal PI projektet såsom CMake för kontroll av kompileringsprocessen, test ramverket Googletest för automatiserad testning samt integrering med dokumentations generatorn Doxygen för att kunna skapa en dokumentation av mjukvaran.
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Sollerhed, Ann-Christin. "Young today - adult tomorrow studies on physical status, physical activity, attitudes, and self-perception in children and adolescents /." Doctoral thesis, Lund : Faculty of Medicine, Lund University, 2006. http://theses.lub.lu.se/postgrad/search.tkl?field_query1=pubid&query1=med_1292&recordformat=display.
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Schwägerl, Christian. "Language contact and displays of social identity : the communicative and ideological dimension of code-mixing in a business setting /." Tübingen : Narr, 2010. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=018862297&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA.
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Borin, Jesper. "Selection and characterization of bispecific ADAPT molecules for enhanced biodistribution in cancer therapy." Thesis, KTH, Skolan för kemi, bioteknologi och hälsa (CBH), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-278699.
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Established biopharmaceuticals such as antibodies and derivatives thereof are relatively large. In cancer therapy, this creates a steep drug concentration gradient within tumors, leaving cells far from blood vessels effectively untreated. Continuous pseudo treatments should foster the development of drug resistance and might lead to eventual disease relapse. Drug concentration gradients can be operationalized as tissue penetration efficiencies, which are functions of molecular size. However, small particles are also subject to potent renal clearance, collapsing the therapeutic window beyond clinical applications. In this master’s thesis, spatial bispecificity was engineered into a single albumin binding domain (ABD). Resulting ABD derived affinity proteins (ADAPTs) are saved from urinary excretion by the grace of HSA, but in the more static microenvironment of tumors, following HSA dissociation, they are capable of tissue penetration efficiencies bestowed only upon smaller particles. To this end, phage display was used to raise ADAPTs against the cancer associated proteins human epidermal growth factor receptor 2 (HER2) and carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6), but also the inflammation marker C-reactive protein (CRP). Via Sanger sequencing, 9 variants were picked for protein production and characterization, among which two spatially bispecific binders were found. ADAPTs were also evaluated for aggregation tendencies, structural conformity to library design, and thermal stability. One ADAPT, binding HER2, passed all tests of initial characterizations. Deep sequencing was used to analyze selection output, from which many more binders should be screened in future experiments.Etablerade bioläkemedel liksom antikroppar och deras derivat är relativt stora protein. Som cancerterapeutiska skapar de således branta koncentrationsgradienter utgående från tumörpenetrerande blodkärl. Detta riskerar att lämna vissa cancerceller utanför det terapeutiska fönstret. Det svaga selektionstryck som således verkar i tumörperiferin fostrar cancerceller till att utveckla resistens mot detsamma. Koncentrationsgradienten beror på proteinets vävnadspenetrarande förmåga, vilken är en funktion av proteinets storlek. Mindre proteiner borde därmed lättare ackumuleras i hela tumören och förebygga resistensutveckling. Problemet med små proteiner är deras mycket korta halveringstid i serum, en följd av relativt obehindrad filtrering ut i urinen via njurarna. I det här examensarbetet utvecklades rumsbispecifika bindare av cancerassocierade protein med hjälp av fagdisplayselektioner från ett proteinbibliotek baserat på en enda albuminbindande domän (ABD). Resulterande ABD deriverade affinitetsprotein (ADAPT) undkommer ovan nämnda filtrering tack vare sin naturligt starka interaktion med humant serumalbumin (HSA). I den mer långsamt flödande tumörmikromiljön tillåts ADAPTerna efter albumindissociation sedan utöva en bland bioläkemedel överlägsen vävnadspenetration. Tre parallella selektionsspår utfördes mot de cancerassocierade målproteinerna human epidermal growth factor receptor 2 (HER2) och carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) samt den utsöndrade inflammationsmarkören C-reaktivt protein (CRP). Via Sangersekvensering kunde flera kandidater identifieras. Bland 6 karakteriserade ADAPTer uppvisade samtliga hög HSA-affinitet, tre konstaterades interagera specifikt med sitt målprotein, och två verkade binda även rumsbispecifikt. ADAPTer utvärderades även för sin benägenhet att bilda aggregat, strukturell överensstämmelse med experimentell design, och värmestabilitet. Endast en bindare, mot HER2, klarade sig genom alla prövningar som proteinkarakteriseringen innebar utan underkänt. Även en högparallel sekvensering utav selektionsresultat utfördes, men utanför de tidsramar som tillät ytterligare karakterisering.
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Bergstrand, Julia, and Julia Contreras. "PODD i interaktion : - En samtalsanalytisk fallstudie av interaktion med AKK." Thesis, Uppsala universitet, Logopedi, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-379257.
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ABSTRACT Background: A language is an individual tool for stimulating and organizing concepts and thinking. Through a language, the individual is also given opportunities to understand the outside world and himself. Not having access to a functional language and means to communicate results in a potential loss of opportunities for development and limitations in all aspects of life. For individuals with language-, speech- and communication difficulties, there are Augmentative and Alternative Communication (AAC). AAC is a collective term for various tools and methods that aim to improve and facilitate communication and interaction between the individual and the persons surrounding them. One type of AAC is Pragmatic Organized Dynamic Display (PODD). Aim: This study aims to investigate what happens during interaction with PODD in conversations between two people using the methodology of Conversation Analysis (CA). Method: A qualitative case study was conducted during a day at a training school where an AAC user ("Adam") and his communication partner ("Elin) interacted with PODD in different everyday activities. The observation was documented with two video cameras. Result: The recorded material totaled three hours. From this amount of video material, a couple of sequences were selected for analysis. The analysis of the material shows that the interaction with PODD is built up sequentially through cooperation between the participants. Participants used different approaches to initiate, maintain and terminate communicative projects with PODD. The analysis also shows that PODD was used to perform various social actions within several different activity types. The results also indicate that it is the partner’s ability to pay attention to, interpret, support and guide the AAC user's communicative initiative, which gives the AAC user the opportunity to participate in the joint communicative projects.SAMMANFATTNING Bakgrund: Ett språk är ett individuellt redskap för att stimulera och organisera begrepp och tänkande. Genom språket ges individen också möjligheter att förstå omvärlden och sig själv. Att inte ha tillgång till ett funktionellt språk och kommunikationssätt innebär att individen riskerar att gå miste om många utvecklingsmöjligheter och bli starkt begränsad i livets samtliga aspekter. För individer med språk, tal och kommunikationssvårigheter finns Alternativ och Kompletterande Kommunikation (AKK). AKK är ett samlingsbegrepp för olika redskap och metoder som avser att förbättra och underlätta kommunikation och interaktion mellan individen och personerna i dennes omgivning. En form av AKK är Pragmatisk Organiserad Dynamisk Display (PODD). Syfte: Denna studie syftar till att med metodologin för Conversation Analysis (CA) undersöka vad som sker i interaktion med PODD under samtal mellan två personer. Metod: En kvalitativ fallstudie som genomfördes under en dag på en träningsskola då en AKK-användare (”Adam”) och hans kommunikationspartner (”Elin) interagerade med PODD i vardagliga aktiviteter. Observationen dokumenterades med två videokameror. Resultat: Det inspelade materialet uppgick till totalt tre timmar. Utifrån denna mängd valdes ett par sekvenser ut för analys. Analysen av materialet visar att interaktionen med PODD byggs upp sekventiellt genom ömsesidigt samarbete mellan deltagarna. Deltagarna använde sig av olika tillvägagångssätt för att initiera, upprätthålla och avsluta kommunikativa projekt med PODD. Analysen visar även att PODD användes för att utföra olika sociala handlingar inom flera olika aktivitetstyper. Resultaten tyder också på att det är kommunikationspartnerns förmåga att uppmärksamma, tolka, stötta och vägleda AKK-användarens kommunikativa initiativ som ger AKK-användaren möjlighet att delta i det gemensamma kommunikativa projektet.
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Park, Milda. "Hand-Auge-Koordination bei videobasierten Augmented-reality-Systemen in der Schweiss- und Medizintechnik /." Aachen : Shaker, 2007. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=016480943&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.
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Butterworth, Mary Michele. "Felinus Domus: A Veterinary Hospital for Cats in Old Town Alexandria, Virginia." Thesis, Virginia Tech, 2004. http://hdl.handle.net/10919/34535.
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Throughout time man has discovered that the human form, in all its harmonious proportion, can be used as a guide, gauge and tool to design and build structures. However, the human figure has not been the only organic form used to create architecture. Many animals create dwellings that synchronize with not only their own unique physical characteristics and survival instincts, but with their aesthetic preferences as well. It is logical that a design should respond to its surroundings, program and most importantly, its inhabitants.
This thesis design is for two specific occupants: the cat and the human. They are both meant to inhabit the building wholly and simultaneously. The way each of them experiences and uses the space, however, differs greatly.
For a building to survive it needs many of the same things as living creatures: sunlight, air and movement, to name a few. It also needs to function like a living creature. It must breathe, sleep, respond to the changing seasons, and adapt over time. This thesis is an investigation of how both human and cat can dwell in a building of harmonious proportion, scale, light, and material.Master of Architecture
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Terziari, Sofia. "telechirurgia robot assistita: evoluzione e stato dell'arte delle principali strumentazioni e reti telematiche." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2020. http://amslaurea.unibo.it/21381/.
Full textAbstract:
La telechirurgia è una tecnica operatoria che permette al medico di eseguire interventi chirurgici su pazienti fisicamente distanti. Il chirurgo esegue l’intervento mediante un sistema robotico con abilità chirurgiche eccezionali, combinato con tecnologie di comunicazione che consentono lo scambio di dati tra le postazioni e l’ausilio di un monitor per il controllo continuo del campo operatorio. In questo lavoro sono analizzati due interventi chirurgici a distanza, con particolare attenzione alle principali strumentazioni e reti telematiche utilizzate.
Il primo intervento chirurgico a distanza è stato effettuato nel 2001, con paziente e chirurgo distanti 6000km. È stata utilizzata una rete ad alta velocità dedicata ATM per la trasmissione dei dati ed il sistema robotico ZEUS. L’intervento, ritenuto rischioso, non è più stato ripetuto.
Nel 2019 a Milano è stato effettuato il primo intervento chirurgico a distanza tramite connessione 5G per la trasmissione dei dati, con paziente e chirurgo distanti 15km. Le principali strumentazioni utilizzate sono: sistema CALM, laser CO2 medicale, robot Panda ed esoscopio stereo 3D VITOM lato paziente; Wacom tablet, dispositivo tattile Omega.7 e display 3D HMZ-T3 lato chirurgo.
Dall’analisi risulta che per il funzionamento delle tecnologie utilizzate in telechirurgia è necessaria una connettività avanzata come quella fornita dal 5G, che garantisce tempi di risposta immediati, maggiore velocità e capacità per il trasferimento dei dati ed estrema affidabilità. Tuttavia, prima che la chirurgia tele-robotica diventi comune è necessario attuare precauzioni, controlli e standard rigorosi.
Per il futuro si auspica che la possibilità di eseguire manipolazioni complesse da postazioni remote consentirà al chirurgo esperto di insegnare o sorvegliare l'esecuzione di tecniche avanzate o nuove mediante intervento in tempo reale. Si elimineranno i vincoli geografici e questo permetterà di ottenere elevate competenze chirurgiche in tutto il Mondo.
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Haarbauer, Eric Stowe. "Proximity compatibility in medical diagnosis displays." 2001. http://purl.galileo.usg.edu/uga%5Fetd/haarbauer%5Feric%5Fs%5F200105%5Fphd.
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Huang, Cheng-Hsun, and 黃政勛. "A Study of Improving Tone Reproduction Curve on Medical Displays." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/03694907989977243552.
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碩士國立臺灣科技大學
色彩與照明科技研究所
103
Recently, under vigorous development, the application of the flat-panel display (FPD) is applied in broader scope and its image reproduction quality also becomes an important role. Take the evolution of display on medical use into consideration, if the pathological image cannot be reproduced clearly in details which may cause doctors confused in making correct diagnosis judgment. However, DICOM (Digital Imaging and Communications in Medicine) has already developed a Grayscale Standard Display Function (GSDF) for medical display devices to ensure that the devices can exhibit a better image performance capability when displaying medical images, such as X-ray photograph etc., these black-and-white images can be reproduced more clear in detailed textures. This paper, following the DICOM 3.14 proposal in the first beginning, evaluates the medical images reproduction performance to the standard monitors found on the marketplaces. The results show far behind to the standard requirements. This is the reason why the complicated calibration procedures are necessary for the merchandized medical LCDs to reach a better display image quality. In our study, finally, a system to improve the medical image display performance which can be applied on the displays with different display characteristics is generated according to the principle of DICOM 3.14 and its color imaging technology application. The Tone Reproduction Curve of the display, using algorithm mentioned in this paper, fulfills the display requirements of GSDF standard and simultaneously meets the characteristics of standard color temperature which increases the medical image quality of display and also satisfies with the image evaluation method criteria of AAPM TG18 proposed by American Association of Physicists in Medicine.
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"Task Relatedness and Spatial Distance of Information: Considerations for Medical Head Mounted Displays." Master's thesis, 2017. http://hdl.handle.net/2286/R.I.44046.
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abstract: The medical field is constantly looking for technological solutions to reduce user-error and improve procedures. As a potential solution for healthcare environments, Augmented Reality (AR) has received increasing attention in the past few decades due to advances in computing capabilities, lower cost, and better displays (Sauer, Khamene, Bascle, Vogt, & Rubino, 2002). Augmented Reality, as defined in Ronald Azuma’s initial survey of AR, combines virtual and real-world environments in three dimensions and in real-time (Azuma, 1997). Because visualization displays used in AR are related to human physiologic and cognitive constraints, any new system must improve on previous methods and be consistently aligned with human abilities in mind (Drascic & Milgram, 1996; Kruijff, Swan, & Feiner, 2010; Ziv, Wolpe, Small, & Glick, 2006). Based on promising findings from aviation and driving (Liu & Wen, 2004; Sojourner & Antin, 1990; Ververs & Wickens, 1998), this study identifies whether the spatial proximity affordance provided by a head-mounted display or alternative heads up display might benefit to attentional performance in a simulated routine medical task. Additionally, the present study explores how tasks of varying relatedness may relate to attentional performance differences when these tasks are presented at different spatial distances.Dissertation/Thesis
Masters Thesis Engineering 2017
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Wang, Yao-Chin, and 王耀金. "Optomechatronics System for TFT Array Flaw Detection of Ultrahigh Resolution Medical and Mobile Displays." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/a24779.
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博士國立交通大學
光電系統博士學位學程
103
To develop leading medical display panels with specially designed features for the biotech and healthcare fields is trend. The global brands for medical display panels currently have recognition for its ultrahigh-resolution, high-brightness, and high-contrast products, which, along with its complete range of panel sizes and specifications, clearly demonstrates the maturity of advanced technology for the development of medical display panels. The medical displays help to diagnosis by providing precise, real-time medical examination imaging and meet high quality with safety standards. In advanced mobile displays have display ultrahigh-resolution images in hand-held devices and provide healthcare applications. However, it is necessary to determine the proper inspection methodology of these ultrahigh-resolution displays and establish an easy testing method for in-process yield requirements on the performance. It measures to ensure proper precision imaging and electrical characteristics. In-process yield is an important parameter for display performance, as it affects the cost and quality which seen at different positions on the display maker. In thin-film-transistor (TFT) array process, TFT array inspection has been used to detect flaws and control process. For ultrahigh-resolution medical and mobile displays, the display pixels on an array panel are getting smaller; therefore, flaw inspection is getting more important and critical for managing yield with quality. In this dissertation, a novel approach for TFT array flaws inspection was proposed. The experimental results show that detecting critical point defect of TFT array can be effectively improved. The detected sub-pixel size for TFT array panels can be smaller than 53 μm of an advanced 30-inch ultrahigh-definition (Ultra HD, UHD) medical display and smaller than 20 μm for a 5-inch full high-definition (Full HD, FHD) mobile display.
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"Three dimensional medical image visualization." Chinese University of Hong Kong, 1994. http://library.cuhk.edu.hk/record=b5888229.
Full textAbstract:
by Tin Pong.Thesis (M.Sc.)--Chinese University of Hong Kong, 1994.
Includes bibliographical references (leaf 73).
Abstract --- p.2
Acknowledgement --- p.4
Table of Contents --- p.5
Chapter I. --- Introduction --- p.8
Chapter II. --- Segmentation Tools --- p.11
Chapter 2.1. --- Segmentation of Object --- p.11
Chapter 2.1.1. --- Segmentation algorithm --- p.11
Chapter 2.1.2. --- Region growing algorithm --- p.16
Chapter 2.2. --- Noise Reduction --- p.19
Chapter 2.2.1. --- Median filtering --- p.19
Chapter 2.2.2 --- Mean filtering --- p.20
Chapter 2.3. --- Other functions --- p.21
Chapter 2.3.1. --- Contrast enhancement and reduction --- p.21
Chapter 2.3.2. --- Brightness increment and reduction --- p.22
Chapter III. --- 3D Visualization Tools --- p.23
Chapter 3.1. --- Interpolation --- p.23
Chapter 3.1.1. --- Estimate distance between slices --- p.23
Chapter 3.1.2. --- Trilinear Interpolation --- p.24
Chapter 3.2. --- Projection --- p.26
Chapter 3.2.1. --- Parallel projection --- p.26
Chapter 3.2.2. --- Z-Buffers --- p.27
Chapter 3.3. --- Rotation of 3D image --- p.29
Chapter 3.4. --- Shading --- p.30
Chapter IV. --- Description of the software developed --- p.32
Chapter 4.1. --- Programming environment --- p.32
Chapter 4.2. --- Software developed --- p.32
Chapter 4.3. --- 2D object segmentation panel --- p.35
Chapter 4.4. --- 3D object segmentation panel --- p.45
Chapter V. --- Results and analysis --- p.56
Chapter 5.1. --- Results of segmentation of object --- p.56
Chapter 5.2. --- Results of 3D visualization tools --- p.64
Chapter VI. --- Future Development --- p.70
Chapter VII. --- Conclusion --- p.72
References --- p.73
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"Interactive Volumetric Holographic Display of Medical Images for Radiotherapy Treatment." 2016. http://repository.lib.cuhk.edu.hk/en/item/cuhk-1292320.
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過去的三十年裡，醫學成像系統越來越多應用於世界各地的診所。最常用的醫學成像系統之一為Beam’sEyeView(BEV)。它能把電腦斷層攝影(CT)及核磁共振造影(MRI)的影片,重新建構三維(3D)影像。它可以有效地幫助放射治療師，説明癌症患者的放射治療計畫。雖然它是有效的，但所顯示的三維影像都只能在二維平面螢幕中顯示，往往易於會造成混淆和限制了其有效性。另一個治療計畫系統是Eclipse系統。Eclipse能提高效率，並提供一些互動的功能。放射治療師需手動於電腦斷層攝影中指定不同器官，從而生成三維圖像。市面上最全面的放療治療規劃與模擬系統是VERT系統。它提供輻射治療訓練，讓學生可以安全地學習放射治療的設置實踐與加強技術理論的概念。這昂貴的系統具有強大的互動式三維顯示器，能夠顯示 CT 和 MRI 圖像。然而，它需要使用三維的眼鏡和其三維投影亦有時不准確。本文提出了針對放射治療的互動式全息圖像顯示系統。系統硬體是一個簡單的全息顯示系統，稱為四側全息顯示系統。該軟體由兩部分組成。第一部分用於轉換BEV圖像和驅動全息顯示系統。它被專為規劃的胸部和頭部放射治療。第二部分用於胃鏡檢查影像處理。它結合了一系列的胃鏡檢查影像，以形成一個全景圖像，然後，生成全息顯示的視圖。它可以用於協助診斷胃腸道(GI)上呼吸道。他們都有互動式控制功能，如放大，縮小，放大和減少，以及旋轉。它與現有的醫學成像系統相比，具有兩個明顯的特徵。首先，它可以顯示醫學圖像三維結構化。其結果是，它能給醫療專業人員明確的視圖，可以進行診斷和放射治療計畫。第二，它是簡單和便宜。其互動功能是簡單的使用。隨著進一步發展，預計新系統很快就會在醫院發現實際應用。
In the past three decades, medical imaging is increasingly used in clinic around the world. One of the most commonly used medical imaging systems is called Beam’s Eye View (BEV). It reconstructs a 3D image from a serial of composite images of both Computed Tomography (CT) and Magnetic Resonance Imaging (MRI). It helps radiologists to plan radiotherapy treatment for cancer patients. While it is effective, the display of 3D images on a 2D flat screen often creates confusion and limits its effectiveness. The other system is the Eclipse Treatment Planning System. Eclipse is designed to increase productivity and provide some interactive functions. Radiologists are required to specify different organs manually slide by slide to generate 3D images. The most comprehensive radiotherapy treatment planning and simulation system is VERT. It provides platform for supplying radiation therapy training. Students can learn theoretical concepts of radiation therapy and practice set up and technique. This expensive system has a powerful interactive 3D display that can show life size CT and MRI images. However, it requires to use 3D gaggles and its 3D projection is sometimes inaccurate.
This thesis presents an interactive volumetric image display system for medical diagnosis and radiotherapy treatment. The system hardware is a simple holographic display system, called the four-side volumetric holographic display system. The software consists of two parts. The first part is used to convert the BEV images and drive the holographic display system. It is designed for planning radiotherapy treatment of chest and head. The second part is used to deal with gastroscopy images. It combines a series of gastroscopy images to form a panoramic image and then, generates the views for holographic display. It can be used for assisting the diagnosis of upper Gastrointestinal (GI) tract. They both have interactive control functions, such as zoom-in, zoom-out, enlarge and reduce, as well as rotate. Comparing to the existing medical imaging systems, it has two distinct features. First, it can display the medical images in a 3D structured manner. As a result, it gives unambiguous view based on which medical professionals can carry on diagnosis and plan for radiotherapy treatment. Second, it is simple and inexpensive. Its interactive functions are straightforward to use. With further development, it is expected that the new system will find practical applications in hospitals soon.
Lu, Yuk Ying.
Thesis M.Phil. Chinese University of Hong Kong 2016.
Includes bibliographical references (leaves ).
Abstracts also in Chinese.
Title from PDF title page (viewed on …).
Detailed summary in vernacular field only.
Detailed summary in vernacular field only.
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Lai, Ying-Syuan, and 賴映瑄. "Design Annotation and Markup Display Consistent Web Solutionfor Medical Images." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/27133820297589046362.
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碩士慈濟大學
醫學資訊學系碩士班
101
Medical imaging plays an important role in helping physicians diagnose and treat diseases. When physicians exam medical imaging and write diagnosis report, physicians often need to make annotations on medical images that correspond to the abnormal findings. We wish the images and annotations can be presented on PACS viewer automatically and consistently for helping another reviewers to exam the findings. However, it is not an easy task to share the annotations across medical image systems. Although DICOM has defined a standard (DICOM Presentation state object) for handling image annotations. However, the specifications are very sophisticate and lots of commercial PACS doesn’t support the specifications. Consequently, the image annotations can’t be exchanged and presented in other PACS systems. This research try to find another solution for sharing image annotations and defined a web based Annotation Image Markup specification. This research use the HTML5 Canvas and SVG (Scalable Vector Graphics) graphics templates for presenting medical imaging and marking annotations. We build a system to convert image annotations generated from conventional PACS systems to the SVG formatted annotations. Consequently, both the annotation generated from conventional PACSs or our system can be presented on the web solution. So the image annotated results will not limited in the execution environment, the result can be presented simply using internet browsers. And the web solution with SVG formatted annotations would be much more convenience for further used in clinical research and analysis than sophisticated DICOM presentation objects that stored in PACS.
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Chang, Chin-Chin, and 張晉欽. "Preliminary Study of Compact and Portable Medical Image Display System." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/81194124342885122923.
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碩士中原大學
電機工程研究所
89
In recent age, the rapid development of medical engineering, and more and more people put in this field, the direction of medical instrument design become more light and portable, but in some medical image display instrument just like PACS(Picture Archiving and Communication System), the PACS volume still large-sized. The developed system hope to combines the advantages of light-LCD display technique and Ethernet transfer system which have the characteristics of the small volume, portable, powerful quality and add other device, like Touch panel, Compact Flash memory, an 4-channel 10-bit resolution analog-to-digital converter(ADC7777). the system chip and device also the new products with new low power consumption technique, the design of the system is want to have qualities of low power, small volume, light-weight, and portable. The main purpose of this research is wanted to develop a multi-function medical image display system with light-LCD display technique, combine the multi-advantages and multi-functions, expect to research a system can use in the clinical environments popularly, and hope to make the system to be a resilience, low cost, low power, consumption and high memory medical display image system.
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Yang, Ting-Wei, and 楊廷偉. "The Display of Medical Signals and Information and Their Applications." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/59855799323075028355.
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碩士國立成功大學
電腦與通信工程研究所
95
We design and implement a contour-based 3D reconstruction system to help users reconstruct 3D objects. Besides, we develop a virtual reality navigation system in human body. Users can navigate the human body and learn some medical knowledge. To reconstruct 3D objects, we present a contour-based 3D reconstruct algorithm. We display the results and evaluate the algorithm. Our purpose is to make the 3D objects more similar to the real world. We also design and implement some tools to manipulate 3D objects and make measurements of the 3D objects. Users can use the system to read a series of human cross-sectional image files and draw the contours of the organs in the images to reconstruct the 3D objects. Therefore, we can obtain 3D human organ models. The 3D models can be used for the 3D scene of the navigation system. In the system, users can navigate through the human body with some simple man-machine interfaces. Besides, we also provide some medical knowledge such as the 2D cross-sectional images to the users while they are navigating so that the users will not get dis-oriented.
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Chen, Fwn-Jeng, and 陳福政. "Medical Image Analysis, Fusion and Display for Multi-Modality Brain Images." Thesis, 1998. http://ndltd.ncl.edu.tw/handle/99173008316124701957.
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碩士國立成功大學
資訊工程學系
86
In recent years, the increase in aging population, traffic and factoryaccidents has multiplied the numbers of cases in brain diseases anddamages. Therefore, the quality for brain diagnosis needs to beimproved by using the newly developed medical imaging devices urgently.A system integrates the information of multi- image modalities will behelpful for physicians to diagnose.The thesis includes two topics. The first topic is to develop a displaymethod, bulls-eye map, to show the quantitative analysis of the distribution of Tc-99m HMPAO in cerebral cortex. The brain lesion can be detected easily by the use of bulls-eye display. In order to understand the geometrical position of the lesion, the brain lesion and the outer skull obtained from MR brain images are combined and then displayed by the semi- boundary surface rendering technique. The second topic is to reconstruct the brain vessels in MRA images by use of a tracking method. The vessels and the outer skull in MRA brain images are also combined and then displayed to analyze morphology of 3-Dblood vessel trees.In order to develop the bulls-eye map, the two-staged thresholdingalgorithm and the distance transformation method are adopted to extractthe outer contour of the cerebral cortex. Then, the cerebral cortex can be determined according to a specific thickness value given by the physician. The intensity information in cerebral cortex will be translated into the bulls-eye map. The color of the bulls-eye plot is set according!to the ratio of the radioactivities in cerebral cortex to the radioactivities in the reference regions, including cerebellar and occipital cortex. In the method to reconstruct the three dimensional vessels, the urchin model is proposed to track the vessel region. The behaviors of the urchin including pinpricks growing, translation, and sub-urchin generation are designed and implemented in the proposed algorithm. Some rules and techniques are also provided to remove the ooises and to connect these vessels.Finally, some real cases are used in our experiments. The images from different modalities can be integrated with the proposed image processing and visualization techniques, and can be measured quantitatively for clinical evaluation.
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YANG, HONG-ZHANG, and 楊弘章. "A study on the reconstruction and display of 3D medical images." Thesis, 1987. http://ndltd.ncl.edu.tw/handle/72141352069404824220.
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