Dissertations / Theses on the topic 'Medical displays'
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Dawood, Richard M. "New technology in radiological diagnosis : an investigation of diagnostic image quality in digital displays of radiographs." Thesis, University College London (University of London), 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289055.
Full textMomenipour, Amirmasoud. "Audio-tactile displays to improve learnability and perceived urgency of alarming stimuli." Diss., University of Iowa, 2019. https://ir.uiowa.edu/etd/6993.
Full textWinterbottom, Marc. "Individual Differences in the Use of Remote Vision Stereoscopic Displays." Wright State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=wright1433453135.
Full textKoelemeijer, Dorien. "The Design and Evaluation of Ambient Displays in a Hospital Environment." Thesis, Malmö högskola, Fakulteten för kultur och samhälle (KS), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-23601.
Full textMcIntire, John Paul. "Investigating the Relationship between Binocular Disparity, Viewer Discomfort, and Depth Task Performance on Stereoscopic 3D Displays." Wright State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=wright1400790668.
Full textBerberich, Katelyn. "Evaluating Mobile Information Display System in Transfer of Care." Wright State University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=wright1503437044573349.
Full textGuarnieri, Gabriele. "High dynamic range images: processing, display and perceptual quality assessment." Doctoral thesis, Università degli studi di Trieste, 2009. http://hdl.handle.net/10077/3121.
Full textThe intensity of natural light can span over 10 orders of magnitude from starlight to direct sunlight. Even in a single scene, the luminance of the bright areas can be thousands or millions of times greater than the luminance in the dark areas; the ratio between the maximum and the minimum luminance values is commonly known as dynamic range or contrast. The human visual system is able to operate in an extremely wide range of luminance conditions without saturation and at the same time it can perceive fine details which involve small luminance differences. Our eyes achieve this ability by modulating their response as a function of the local mean luminance with a process known as local adaptation. In particular, the visual sensation is not linked to the absolute luminance, but rather to its spatial and temporal variation. One consequence of the local adaptation capability of the eye is that the objects in a scene maintain their appearance even if the light source illuminating the scene changes significantly. On the other hand, the technologies used for the acquisition and reproduction of digital images are able to handle correctly a significantly smaller luminance range of 2 to 3 orders of magnitude at most. Therefore, a high dynamic range (HDR) image poses several challenges and requires the use of appropriate techniques. These elementary observations define the context in which the entire research work described in this Thesis has been performed. As indicated below, different fields have been considered; they range from the acquisition of HDR images to their display, from visual quality evaluation to medical applications, and include some developments on a recently proposed class of display equipment. An HDR image can be captured by taking multiple photographs with different exposure times or by using high dynamic range sensors; moreover, synthetic HDR images can be generated with computer graphics by means of physically-based algorithms which often involve advanced lighting simulations. An HDR image, although acquired correctly, can not be displayed on a conventional monitor. The white level of most devices is limited to a few hundred cd/m² by technological constraints, primarily linked to the power consumption and heat dissipation; the black level also has a non negligible luminance, in particular for devices based on the liquid crystal technology. However, thanks to the aforementioned properties of the human visual system, an exact reproduction of the luminance in the original scene is not strictly necessary in order to produce a similar sensation in the observer. For this purpose, dynamic range reduction algorithms have been developed which attenuate the large luminance variations in an image while preserving as far as possible the fine details. The most simple dynamic range reduction algorithms map each pixel individually with the same nonlinear function commonly known as tone mapping curve. One operator we propose, based on a modified logarithmic function, has a low computational cost and contains one single user-adjustable parameter. However, the methods belonging to this category can reduce the visibility of the details in some portions of the image. More advanced methods also take into account the pixel neighborhood. This approach can achieve a better preservation of the details, but the loss of one-to-one mapping from input luminances to display values can lead to the formation of gradient reversal effects, which typically appear as halos around the object boundaries. Different solutions to this problem have been attempted. One method we introduce is able to avoid the formation of halos and intrinsically prevents any clipping of the output display values. The method is formulated as a constrained optimization problem, which is solved efficiently by means of appropriate numerical methods. In specific applications, such as the medical one, the use of dynamic range reduction algorithms is discouraged because any artifacts introduced by the processing can lead to an incorrect diagnosis. In particular, a one-to-one mapping from the physical data (for instance, a tissue density in radiographic techniques) to the display value is often an essential requirement. For this purpose, high dynamic range displays, capable of reproducing images with a wide luminance range and possibly a higher bit depth, are under active development. Dual layer LCD displays, for instance, use two liquid crystal panels stacked one on top of the other over an enhanced backlight unit in order to achieve a dynamic range of 4 ÷ 5 orders of magnitude. The grayscale reproduction accuracy is also increased, although a “bit depth” can not be defined unambiguously because the luminance levels obtained by the combination of the two panels are partially overlapped and unevenly spaced. A dual layer LCD display, however, requires the use of complex splitting algorithms in order to generate the two images which drive the two liquid crystal panels. A splitting algorithm should compensate multiple sources of error, including the parallax introduced by the viewing angle, the gray-level clipping introduced by the limited dynamic range of the panels, the visibility of the reconstruction error, and glare effects introduced by an unwanted light scattering between the two panels. For these reasons, complex constrained optimization techniques are necessary. We propose an objective function which incorporates all the desired constraints and requirements and can be minimized efficiently by means of appropriate techniques based on multigrid methods. The quality assessment of high dynamic range images requires the development of appropriate techniques. By their own nature, dynamic range reduction algorithms change the luminance values of an image significantly and make most image fidelity metrics inapplicable. Some particular aspects of the methods can be quantified by means of appropriate operators; for instance, we introduce an expression which describes the detail attenuation introduced by a tone mapping curve. In general, a subjective quality assessment is preferably performed by means of appropriate psychophysical experiments. We conducted a set of experiments, targeted specifically at measuring the level of agreement between different users when adjusting the parameter of the modified logarithmic mapping method we propose. The experimental results show a strong correlation between the user-adjusted parameter and the image statistics, and suggest a simple technique for the automatic adjustment of this parameter. On the other hand, the quality assessment in the medical field is preferably performed by means of objective methods. In particular, task-based quality measures evaluate by means of appropriate observer studies the clinical validity of the image used to perform a specific diagnostic task. We conducted a set of observer studies following this approach, targeted specifically at measuring the clinical benefit introduced by a high dynamic range display based on the dual layer LCD technology over a conventional display with a low dynamic range and 8-bit quantization. Observer studies are often time consuming and difficult to organize; in order to increase the number of tests, the human observers can be partially replaced by appropriate software applications, known as model observers or computational observers, which simulate the diagnostic task by means of statistical classification techniques. This thesis is structured as follows. Chapter 1 contains a brief background of concepts related to the physiology of human vision and to the electronic reproduction of images. The description we make is by no means complete and is only intended to introduce some concepts which will be extensively used in the following. Chapter 2 describes the technique of high dynamic range image acquisition by means of multiple exposures. In Chapter 3 we introduce the dynamic range reduction algorithms, providing an overview of the state of the art and proposing some improvements and novel techniques. In Chapter 4 we address the topic of quality assessment in dynamic range reduction algorithms; in particular, we introduce an operator which describes the detail attenuation introduced by tone mapping curves and describe a set of psychophysical experiments we conducted for the adjustment of the parameter in the modified logarithmic mapping method we propose. In Chapter 5 we move to the topic of medical images and describe the techniques used to map the density data of radiographic images to display luminances. We point out some limitations of the current technical recommendation and propose an improvement. In Chapter 6 we describe in detail the dual layer LCD prototype and propose different splitting algorithms for the generation of the two images which drive the two liquid crystal panels. In Chapter 7 we propose one possible technique for the estimation of the equivalent bit depth of a dual layer LCD display, based on a statistical analysis of the quantization noise. Finally, in Chapter 8 we address the topic of objective quality assessment in medical images and describe a set of observer studies we conducted in order to quantify the clinical benefit introduced by a high dynamic range display. No general conclusions are offered; the breadth of the subjects has suggested to draw more focused comments at the end of the individual chapters.
XXI Ciclo
1982
Plesniak, Wendy J. (Wendy Jean). "Volumetric rendering for holographic display of medical data." Thesis, Massachusetts Institute of Technology, 1988. http://hdl.handle.net/1721.1/63193.
Full textIncludes bibliographical references.
Work funded by a joint IBM/MIT agreement.
by Wendy J. Plesniak.
M.S.
Moura, Lincoln de Assis. "A system for the reconstruction, handling and display of three-dimensional medical structures." Thesis, Imperial College London, 1988. http://hdl.handle.net/10044/1/47192.
Full textFisher, Henry Donald 1943. "DESIGN OF REVIEW CONSOLE FOR RADIOLOGY APPLICATIONS (DISPLAY, PACS)." Thesis, The University of Arizona, 1986. http://hdl.handle.net/10150/291634.
Full textAsplund, Raquel. "Evaluation of a cloud-based image analysis and image display system for medical images." Thesis, Umeå universitet, Institutionen för tillämpad fysik och elektronik, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-105984.
Full textFan, Jiahua. "Development of Image Display-Specific Evaluation and Optimization Schemes." Diss., The University of Arizona, 2006. http://hdl.handle.net/10150/195754.
Full textWang, Yu. "Mechanistic study of aryl hydrocarbon receptor nuclear translocator (ARNT)-mediated signaling." Scholarly Commons, 2013. https://scholarlycommons.pacific.edu/uop_etds/151.
Full textLei, Xin. "Analyzing “Design + Medical” Collaboration Using Participatory Action Research (PAR): A Case Study of the Oxygen Saturation Data Display Project at Cincinnati Children’s Hospital Medical Center." University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1427983695.
Full textBirnstock, Jan. "Siebdruck von Displays auf Basis konjugierter Polymere /." Aachen : Shaker, 2003. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=010465063&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.
Full textBlack, David Verfasser], Horst [Akademischer Betreuer] Hahn, Jürgen [Gutachter] Schönwälder, Andreas [Gutachter] Nüchter, and Jörn [Gutachter] [Loviscach. "Auditory Display for Image-Guided Medical Interventions / David Black ; Gutachter: Jürgen Schönwälder, Andreas Nüchter, Jörn Loviscach ; Betreuer: Horst Hahn." Bremen : IRC-Library, Information Resource Center der Jacobs University Bremen, 2019. http://d-nb.info/1182033687/34.
Full textSnape, Julia. "Medieval art on display, 1750-2010." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/medieval-art-on-display-17502010(9e0b3b30-1d52-412d-862a-b655757307b1).html.
Full textAndersson, Ken G. "Combinatorial Protein Engineering Of Affibody Molecules Using E. Coli Display And Rational Design Of Affibody-Based Tracers For Medical Imaging." Doctoral thesis, KTH, Proteinteknologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-213451.
Full textQC 20170904
Stenstrom, Joyce E. "Effects of cinematic factors on the perception of wrist postures when viewed on a video display." Thesis, This resource online, 1991. http://scholar.lib.vt.edu/theses/available/etd-03022010-020204/.
Full textKang, Robin. "Heart frontal section and hypertrophic cardiomyopathy /." Online version of thesis, 2010. http://hdl.handle.net/1850/11651.
Full textRehm, Kelly. "Development and image quality assessment of a contrast-enhancement algorithm for display of digital chest radiographs." Diss., The University of Arizona, 1992. http://hdl.handle.net/10150/185844.
Full textGermishuizen, Juanita. "Does the private health care sector display oligopolistic characteristics in South Africa?" Thesis, Stellenbosch : University of Stellenbosch, 2009. http://hdl.handle.net/10019.1/996.
Full textENGLISH ABSTRACT: In the field of Economics, the term “competition” refers to the method involved in steering an increase in supply, which leads to a decrease in equilibrium price and an increase in equilibrium quantity. However, competition involves more than just an increase in supply. In any economy, competition can affect factors, such as innovation, efficiency and the accessibility to goods and services. In some cases, the effect might not be positive, if the goods and services only benefit certain parties involved, rather than the general population. Traditionally, there are four basic types of market structure, with each structure displaying unique market power characteristics, which are initiated by an organisation’s profit motives. All market structures, other than that of perfect competition, are forms of imperfect competition. One such imperfect market structure is oligopoly, which has certain unique characteristics (Doyle, 2005:198). In the private health care sector, cost increases can be related to the increased market concentration, due to the increase of market power by hospital groups. Therefore, the prevalence of competition in the private health care sector should be monitored. That health care functions in a dynamic environment has been historically proven and can also be seen in the latest trends. A bundle of factors, rather than a single factor, determines success. Any overview of the international health care industry should demonstrate the rapid development of the industry. The industry, compared with the relatively elementary and experimental health care system of a few decades ago, is currently super specialised. A shift has taken place in the market from the role of the industry as a government-funded health care provider to that of a private hospital provider. In South Africa, the complexity of the health care sector is made even more complex by the many role-players and the interaction between the different private and public health providers. The cost of access to hospitals should be prioritised. Research shows that the private health care sector caters for the health needs of almost seven million people, who comprise only 15% of the total population. However, the sector has spent more money than the entire public sector, with the per capita expenditure exceeding that of the public sector eightfold. The increase in the cost of private hospitals in South Africa has been caused by changes in the market concentration. Such expenditure has given the private hospitals greater market power and has influenced their behaviour.
AFRIKAANSE OPSOMMING: In ekonomie verwys die term “kompetisie” na die metode betrokke om ’n toename in aanbod te veroorsaak, wat weer ’n verlaging in die ewewigsprys en ’n verhoging in die ewewigshoeveelheid tot gevolg het. Kompetisie behels egter meer as net ’n verhoging in aanbod. In enige ekonomie kan kompetisie faktore soos innovasie, doeltreffendheid en toegang tot goedere en dienste beïnvloed. In sommige gevalle is die effek egter nie positief nie, soos wanneer goedere en dienste slegs sekere belanghebbendes bevoordeel in plaas van die algemene publiek. Daar is, tradisioneel gesproke, vier basiese markstrukture wat elkeen unieke markbeherende eienskappe toon wat deur die organisasie se winsmotiewe geïnisieer word. Alle markstrukture, behalwe volmaakte kompetisie, is vorms van onvolmaakte kompetisie. Een so ’n markstruktuur is oligopolie wat sekere unieke eienskappe toon. In die privaat–gesondheidsorgsektor, is kosteverhogings gekoppel aan verhoogde markkonsentrasie as gevolg van die toename in privaat hospitaalgroepe. Kompetisie in die privaat-gesondheidsorgsektor moet dus gemonitor word. Dat gesondheidsorg in ’n dinamiese omgewing funksioneer is reeds bewys en kan ook in die nuutste tendense gesien word. Dit is egter ‘n hele groep faktore, nie slegs een faktor nie, wat sukses waarborg. ’n Oorsig van die internasionale gesondheidsorgindustrie toon dat ontwikkelinge in die industrie baie vinnig vorder. Vandag is gesondheidsorg uiters gespesialiseerd in vergelyking met dekades terug, toe dit relatief elementêr en eksperimenteel was. Die rol van die industrie het verskuif van ’n staats-gesubsidieerde diens na waar dit vandag grootliks deur privaat instansies gelewer word. In Suid-Afrika word ’n reeds komplekse gesondheidsorgsektor meer gekompliseer deur die baie rolspelers in die sektor asook die interaksie tussen die verskillende privaat- en staatsgesondheidsorgvoorsieners. Die koste van toegang tot hospitale behoort ’n prioriteit te wees. Navorsing toon dat die die privaatgesondheidsorgsektor dienste aan sewe miljoen mense bied wat slegs 15% van die totale populasie is. Hierdie sektor spandeer egter baie meer as die met ’n per capita uitgawe byna agt keer meer as staatsgesondheidsorg. Die oorsaak van koste verhogings in privaatgesondheidsorg in Suid-Afrikaanse hospitale is veroorsaak deur veranderinge in die konsentrasie van die privaatgesondheidsorgsektor. Dit gee privaathospitale groter markmag en beïnvloed dus hul optrede.
Vercillo, Richard 1953. "Very high resolution video display memory and base image memory for a radiologic image analysis console." Thesis, The University of Arizona, 1988. http://hdl.handle.net/10150/276707.
Full textFilipovic, Nedim. "Phage display to identify functional resistance mutations to Rigosertib." Scholarship @ Claremont, 2017. http://scholarship.claremont.edu/cmc_theses/1475.
Full textZIPPILLI, Lorenza. "Epitope mapping of a mAb against the factor H binding protein (fHbp) of N. meningitidis by phage display." Doctoral thesis, Università degli studi del Molise, 2012. http://hdl.handle.net/11695/66305.
Full textNo broadly protective vaccine is yet available for the prevention of group B meningococcal disease. One promising vaccine lead is the factor H binding protein (fHbp), a surface-exposed lipoprotein, which is present in all strains of Neisseria meningitidis. This protein binds human factor H (fH), contributing to the ability of these bacteria to avoid complement-mediated killing. The fHbp is a component of a serogroup B meningococcal vaccine currently in late-phase clinical development. Based on the sequence variability of the entire protein, fHbp has been divided into 3 variant groups or 2 sub-families and its architecture is modular, consisting of 5 variable segments, amino acid residues in position between 100 and 255 have been identified as important targets of variant-specific bactericidal antibodies. A panel of anti-fHbp mAbs has been produced from mice immunized with each of the 3 variants of fHbp and all their epitopes have been mapped, except that of the mAb designated JAR 36. This antibody was isolated from a mouse immunized with fHbp of the antigenic variant 3 group, but it cross-reacts with all fHbp sequences in the variant 2 group and elicits complement-mediated cooperative bactericidal activity with JAR 13 and JAR 11. We have screened phage displayed random peptide libraries to identify amino acid residues composing the JAR 36 epitope, putative mapping hypotheses have been then validated by constructing recombinant fHbps single-point variants through site-specific mutagenesis, and analyzing their reactivity with the mAb. Moreover, by using a computational tool, a total of seventeen residues have been identified as possibly constituting the epitope of JAR 36. Eight of these residues are located in a segment of fHbp previously recognized to play an important role in the binding of JAR 36 and four of them are common in variant groups 2 and 3. Both the amino acid identified by phage display and the “in silico”-predicted epitope are located in the proximity of the fH-binding site. This finding is according with previous experimental data, of JAR 36 partially inhibiting binding of fH to fHbp. The data reported will help in characterizing the molecular mechanism of immune protection against MenB, toward the development of safer and effective protein-based vaccines for the prevention of group B meningitis.
Ek, Moira. "Bacterial Display of a Tau-Binding Affibody Construct:Towards Affinity Maturation." Thesis, KTH, Skolan för kemi, bioteknologi och hälsa (CBH), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-278580.
Full textAggregering av mikrotubuli-associerat protein tau är involverad i patologin av flera neurodegenerativa sjukdomar, däribland Alzheimers sjukdom. Affibodymolekylen TP4 har visat sig inhibera denna aggregeringsprocess, och överföring av dess målbindande positioner till ett dimeriskt affibodyprotein har tidigare gett upphov till seqTP4, en så kallad sequestrin. Detta projekt utgör ett led i processen att affinitetsmaturera seqTP4, med hjälp av två olika metoder för presentation av proteiner på ytan av bakterieceller. Ett error-prone PCR-bibliotek uttrycktes först på ytan av Staphylococcus carnosus-celler för selektion av varianter med ökad affinitet för tau, vilket resulterade i ett bibliotek av 1.4×107 transformanter. Flödescytometriska tester tydde på svårigheter i detta upplägg på grund av ospecifika interaktioner, och emedan flera olika angreppssätt för att förmildra dessa problem undersöktes, misslyckades slutligen två cellsorteringsförsök. Omkloning av seqTP4 och biblioteket till en vektor för ytpresentation på Escherichia coli resulterade i funktionellt ytuttryck av seqTP4 på E. coli JK321- och BL21-celler, och ett BL21-bibliotek bestående av 1.6×109 transformanter. Ett första flödescytometriskt test av detta bibliotek tyder på närvaron av varianter med förbättrad förmåga att binda tau, och vägen ligger nu relativt öppen för cellsortering.
McEwen, Timothy Ryan. "Development and Evaluation of an Ecological Display for the Detection, Evaluation, and Treatment of Cardiovascular Risk." Wright State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=wright1386593713.
Full textKaiser, Jochen. "Verwendung stereoskopischer Informationsdarstellung in durchsichtfähigen Anzeigen am Beispiel eines Head-Up Displays /." Stuttgart : Ergonomia Verl, 2004. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=015474744&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.
Full textHuang, Li-Chieh. "Development of a novel bead display technology to identify protein ligands : application to identification of viral entry inhibitors and T-cell epitopes." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:7ca21487-7e7d-4552-8e16-65ec181c7bcc.
Full textRuiz, Altisent Marc. "Advanced illumination and view-selection techniques for volume rendering and its application to medical imaging." Doctoral thesis, Universitat de Girona, 2012. http://hdl.handle.net/10803/371154.
Full textLa visualització de volums és un mètode per extreure informació de dades volumètriques mitjançant imatges interactives. L’objectiu és assistir la interpretació visual de dades creant models tridimensionals que reprodueixen objectes reals amb suficient detall i velocitat per permetre’n la manipulació interactivament. La visualització il·lustrativa millora la percepció de les característiques d'un volum. La visualització de volums té dos objectius principals: obtenir imatges d’alta qualitat en temps real, i determinar com explorar volums d'una manera efectiva. En aquesta tesi avancem en aquestes dues línies. Proposem diversos mètodes per aproximar la il·luminació global amb baix cost computacional, permetent la visualització realista i il·lustrativa. També presentem un mètode per definir automàticament funcions de transferència donada una distribució objectiu. A més, presentem un mètode per automatitzar la creació d’exploded views. Finalment, explorem tècniques per seleccionar els millors punts de vista d’un volum. Diverses de les contribucions estan basades en la teoria de la informació.
Sulaiman, Lanre Precieux Kabir. "Seleção de motivos semelhantes a Papilomavírus, a partir de bibliotecas de phage display, que apresentem potencial aplicação translacional." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/5/5155/tde-29012018-133017/.
Full textThe link between high-risk human papillomavirus and cervical cancer is well established. Despite the existence of prophylactic vaccines against infections by the most common types of HPV, therapeutic alternatives are limited for infections and tumors caused by these viruses. We found some homology motifs for high-risk HPV proteins during the immune-panning of a phage display library with sera from HPV-16- seropositive participants of the Ludwig-McGill cohort. After enrichment of the sequences, the recombinant bacteriophages were purified and amplified for use as immunogens. Using a prophylactic approach, we vaccinated experimentally immunocompetent mice with one of our recombinant bacteriophages using the insertless bacteriophage as a control. These mice were then challenged with TC-1 tumor cells (HPV-16 positive), and the immune responses triggered during tumor progression were evaluated. We also used a therapeutic approach where mice were first injected with tumor cells and immunized with the bacteriophage after tumor establishment. Tumor growth was monitored and tumors, spleen and lymph nodes were evaluated for the quantity and quality of the immune response. ELISA tests revealed that all vaccinated mice responded to immunization with the different bacteriophages. Tumor growth was significantly reduced in prophylactic and therapeutic immunizations, although tumor reduction was minimal when mice were treated 9 days after TC-1 cells grafting. The reduction in tumor growth also translated into a significantly greater survival for the immunized mice. Cell infiltration studies did not reveal changes in several immune subpopulations, but an upward trend in cytotoxic T lymphocytes was observed in mice immunized with PEP1 (insert-containing bacteriophage). The importance of this increase in CD8 in the observed reduction of tumor growth was confirmed using CD8-knockout mice, where the previously observed reduction of tumor growth was abolished. An increase in CD8:CD4 rate was observed in the immunized mice and this is an indication of a cytotoxic tumor environment. Cell proliferation assays to test the antigen specificity of lymphocytes from immunized mice were, however, inconclusive; likewise, we could not change the pattern observed with the use of CpG adjuvant. The usefulness of the phage display technique was also observed in this experimental work. Additional studies to understand the mechanism of action of these recombinant phages in the control of HPV tumor growth and its immunostimulatory potential are warranted
Röstin, Martin. "Development of a Flexible Software Framework for Biosignal PI : An Open-Source Biosignal Acquisition and Processing System." Thesis, KTH, Skolan för teknik och hälsa (STH), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-183525.
Full textAllt eftersom världens befolkning åldras, ställs sjukvården inför nya utmaningar i att behandla fler patienter till en lägre kostnad än idag. En trend för att lösa detta problem är att utöka möjligheterna till vård i hemmet.För att kunna göra detta finns det ett ökande behov av säkra och kostnadseffektiva patientövervakningssystem. Biosignal PI är ett pågående projekt med öppen källkod som skapats för att utveckla en flexibel och prisvärd plattform för utveckling av fristående enheter som kan mäta och bearbeta olika fysiologiska signaler. Detta examensarbete genomfördes vid institutionen för medicinska sensorer, signaler och system vid Skolan för Teknik och Hälsa. Projektet syftade till att vidareutveckla den befintliga mjukvaran för Biosignal PI genom att skapa ett nytt flexibelt mjukvaruramverk som kan användas för mätning och bearbetning av olika typer av biosignaler.Projektet syftade också till att utvidga mjukvaran och lägga till funktioner för att kunna genomföra hjärtfrekvensvariabilitets(HRV) analys i Biosignal PIs mjukvara, samt att utveckla ett grafiskt användargränssnitt(GUI) för hårdvarumodulen PiFace Control and Display. Projektet har utvecklat ett nytt flexibelt mjukvaruramverk för Biosignal PI. Det nya ramverket konstruerades för att abstrahera alla hårdvaruspecifika delar in i mindre utbytbara moduler, med tanken att modulerna ska vara oberoende i hur de hanterar sin specifika uppgift. På så sätt ska det vara möjligt att göra ändringar i Biosignal PIs programvara utan att behöva skriva om hela mjukvaran.Det nyutvecklade Biosignal PI ramverket implementerades i det befintliga hårdvaru systemet, som består av en Raspberry PI, liten och prisvärd enkortsdator, ansluten till ADAS1000, en analog hårdvarumodul med möjlighet att registrera ett elektrokardiografi(EKG/ECG). För att kontrollera Biosignal PI programmet har två olika grafiska användargränssnitt skapats.Det ena gränssnitt är en utvidgning av original programvaran med tillagd funktionalitet för att kunna göra HRV-Analys på Raspberry PI, detta gränssnitt kräver dock mus och dataskärm för att kunna användas.För att kunna styra Biosignal PI utan mus och skärm skapades det även ett gränssnitt för PiFace Control and Display. PiFace gränssnittet gör det möjligt för användaren att samla in och lagra EKG-signaler utan att behöva en stor datorskärm, på så sätt kan man öka Biosignal PI systemets mobilitet. För att underlätta utvecklingsprocessen, samt göra projektet mer förenligt med det medicintekniska regelverket, har ett par utvecklingsverktyg integrerats till Biosignal PI projektet såsom CMake för kontroll av kompileringsprocessen, test ramverket Googletest för automatiserad testning samt integrering med dokumentations generatorn Doxygen för att kunna skapa en dokumentation av mjukvaran.
Sollerhed, Ann-Christin. "Young today - adult tomorrow studies on physical status, physical activity, attitudes, and self-perception in children and adolescents /." Doctoral thesis, Lund : Faculty of Medicine, Lund University, 2006. http://theses.lub.lu.se/postgrad/search.tkl?field_query1=pubid&query1=med_1292&recordformat=display.
Full textSchwägerl, Christian. "Language contact and displays of social identity : the communicative and ideological dimension of code-mixing in a business setting /." Tübingen : Narr, 2010. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=018862297&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA.
Full textBorin, Jesper. "Selection and characterization of bispecific ADAPT molecules for enhanced biodistribution in cancer therapy." Thesis, KTH, Skolan för kemi, bioteknologi och hälsa (CBH), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-278699.
Full textEtablerade bioläkemedel liksom antikroppar och deras derivat är relativt stora protein. Som cancerterapeutiska skapar de således branta koncentrationsgradienter utgående från tumörpenetrerande blodkärl. Detta riskerar att lämna vissa cancerceller utanför det terapeutiska fönstret. Det svaga selektionstryck som således verkar i tumörperiferin fostrar cancerceller till att utveckla resistens mot detsamma. Koncentrationsgradienten beror på proteinets vävnadspenetrarande förmåga, vilken är en funktion av proteinets storlek. Mindre proteiner borde därmed lättare ackumuleras i hela tumören och förebygga resistensutveckling. Problemet med små proteiner är deras mycket korta halveringstid i serum, en följd av relativt obehindrad filtrering ut i urinen via njurarna. I det här examensarbetet utvecklades rumsbispecifika bindare av cancerassocierade protein med hjälp av fagdisplayselektioner från ett proteinbibliotek baserat på en enda albuminbindande domän (ABD). Resulterande ABD deriverade affinitetsprotein (ADAPT) undkommer ovan nämnda filtrering tack vare sin naturligt starka interaktion med humant serumalbumin (HSA). I den mer långsamt flödande tumörmikromiljön tillåts ADAPTerna efter albumindissociation sedan utöva en bland bioläkemedel överlägsen vävnadspenetration. Tre parallella selektionsspår utfördes mot de cancerassocierade målproteinerna human epidermal growth factor receptor 2 (HER2) och carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) samt den utsöndrade inflammationsmarkören C-reaktivt protein (CRP). Via Sangersekvensering kunde flera kandidater identifieras. Bland 6 karakteriserade ADAPTer uppvisade samtliga hög HSA-affinitet, tre konstaterades interagera specifikt med sitt målprotein, och två verkade binda även rumsbispecifikt. ADAPTer utvärderades även för sin benägenhet att bilda aggregat, strukturell överensstämmelse med experimentell design, och värmestabilitet. Endast en bindare, mot HER2, klarade sig genom alla prövningar som proteinkarakteriseringen innebar utan underkänt. Även en högparallel sekvensering utav selektionsresultat utfördes, men utanför de tidsramar som tillät ytterligare karakterisering.
Bergstrand, Julia, and Julia Contreras. "PODD i interaktion : - En samtalsanalytisk fallstudie av interaktion med AKK." Thesis, Uppsala universitet, Logopedi, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-379257.
Full textSAMMANFATTNING Bakgrund: Ett språk är ett individuellt redskap för att stimulera och organisera begrepp och tänkande. Genom språket ges individen också möjligheter att förstå omvärlden och sig själv. Att inte ha tillgång till ett funktionellt språk och kommunikationssätt innebär att individen riskerar att gå miste om många utvecklingsmöjligheter och bli starkt begränsad i livets samtliga aspekter. För individer med språk, tal och kommunikationssvårigheter finns Alternativ och Kompletterande Kommunikation (AKK). AKK är ett samlingsbegrepp för olika redskap och metoder som avser att förbättra och underlätta kommunikation och interaktion mellan individen och personerna i dennes omgivning. En form av AKK är Pragmatisk Organiserad Dynamisk Display (PODD). Syfte: Denna studie syftar till att med metodologin för Conversation Analysis (CA) undersöka vad som sker i interaktion med PODD under samtal mellan två personer. Metod: En kvalitativ fallstudie som genomfördes under en dag på en träningsskola då en AKK-användare (”Adam”) och hans kommunikationspartner (”Elin) interagerade med PODD i vardagliga aktiviteter. Observationen dokumenterades med två videokameror. Resultat: Det inspelade materialet uppgick till totalt tre timmar. Utifrån denna mängd valdes ett par sekvenser ut för analys. Analysen av materialet visar att interaktionen med PODD byggs upp sekventiellt genom ömsesidigt samarbete mellan deltagarna. Deltagarna använde sig av olika tillvägagångssätt för att initiera, upprätthålla och avsluta kommunikativa projekt med PODD. Analysen visar även att PODD användes för att utföra olika sociala handlingar inom flera olika aktivitetstyper. Resultaten tyder också på att det är kommunikationspartnerns förmåga att uppmärksamma, tolka, stötta och vägleda AKK-användarens kommunikativa initiativ som ger AKK-användaren möjlighet att delta i det gemensamma kommunikativa projektet.
Park, Milda. "Hand-Auge-Koordination bei videobasierten Augmented-reality-Systemen in der Schweiss- und Medizintechnik /." Aachen : Shaker, 2007. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=016480943&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.
Full textButterworth, Mary Michele. "Felinus Domus: A Veterinary Hospital for Cats in Old Town Alexandria, Virginia." Thesis, Virginia Tech, 2004. http://hdl.handle.net/10919/34535.
Full textMaster of Architecture
Terziari, Sofia. "telechirurgia robot assistita: evoluzione e stato dell'arte delle principali strumentazioni e reti telematiche." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2020. http://amslaurea.unibo.it/21381/.
Full textHaarbauer, Eric Stowe. "Proximity compatibility in medical diagnosis displays." 2001. http://purl.galileo.usg.edu/uga%5Fetd/haarbauer%5Feric%5Fs%5F200105%5Fphd.
Full textHuang, Cheng-Hsun, and 黃政勛. "A Study of Improving Tone Reproduction Curve on Medical Displays." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/03694907989977243552.
Full text國立臺灣科技大學
色彩與照明科技研究所
103
Recently, under vigorous development, the application of the flat-panel display (FPD) is applied in broader scope and its image reproduction quality also becomes an important role. Take the evolution of display on medical use into consideration, if the pathological image cannot be reproduced clearly in details which may cause doctors confused in making correct diagnosis judgment. However, DICOM (Digital Imaging and Communications in Medicine) has already developed a Grayscale Standard Display Function (GSDF) for medical display devices to ensure that the devices can exhibit a better image performance capability when displaying medical images, such as X-ray photograph etc., these black-and-white images can be reproduced more clear in detailed textures. This paper, following the DICOM 3.14 proposal in the first beginning, evaluates the medical images reproduction performance to the standard monitors found on the marketplaces. The results show far behind to the standard requirements. This is the reason why the complicated calibration procedures are necessary for the merchandized medical LCDs to reach a better display image quality. In our study, finally, a system to improve the medical image display performance which can be applied on the displays with different display characteristics is generated according to the principle of DICOM 3.14 and its color imaging technology application. The Tone Reproduction Curve of the display, using algorithm mentioned in this paper, fulfills the display requirements of GSDF standard and simultaneously meets the characteristics of standard color temperature which increases the medical image quality of display and also satisfies with the image evaluation method criteria of AAPM TG18 proposed by American Association of Physicists in Medicine.
"Task Relatedness and Spatial Distance of Information: Considerations for Medical Head Mounted Displays." Master's thesis, 2017. http://hdl.handle.net/2286/R.I.44046.
Full textDissertation/Thesis
Masters Thesis Engineering 2017
Wang, Yao-Chin, and 王耀金. "Optomechatronics System for TFT Array Flaw Detection of Ultrahigh Resolution Medical and Mobile Displays." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/a24779.
Full text國立交通大學
光電系統博士學位學程
103
To develop leading medical display panels with specially designed features for the biotech and healthcare fields is trend. The global brands for medical display panels currently have recognition for its ultrahigh-resolution, high-brightness, and high-contrast products, which, along with its complete range of panel sizes and specifications, clearly demonstrates the maturity of advanced technology for the development of medical display panels. The medical displays help to diagnosis by providing precise, real-time medical examination imaging and meet high quality with safety standards. In advanced mobile displays have display ultrahigh-resolution images in hand-held devices and provide healthcare applications. However, it is necessary to determine the proper inspection methodology of these ultrahigh-resolution displays and establish an easy testing method for in-process yield requirements on the performance. It measures to ensure proper precision imaging and electrical characteristics. In-process yield is an important parameter for display performance, as it affects the cost and quality which seen at different positions on the display maker. In thin-film-transistor (TFT) array process, TFT array inspection has been used to detect flaws and control process. For ultrahigh-resolution medical and mobile displays, the display pixels on an array panel are getting smaller; therefore, flaw inspection is getting more important and critical for managing yield with quality. In this dissertation, a novel approach for TFT array flaws inspection was proposed. The experimental results show that detecting critical point defect of TFT array can be effectively improved. The detected sub-pixel size for TFT array panels can be smaller than 53 μm of an advanced 30-inch ultrahigh-definition (Ultra HD, UHD) medical display and smaller than 20 μm for a 5-inch full high-definition (Full HD, FHD) mobile display.
"Three dimensional medical image visualization." Chinese University of Hong Kong, 1994. http://library.cuhk.edu.hk/record=b5888229.
Full textThesis (M.Sc.)--Chinese University of Hong Kong, 1994.
Includes bibliographical references (leaf 73).
Abstract --- p.2
Acknowledgement --- p.4
Table of Contents --- p.5
Chapter I. --- Introduction --- p.8
Chapter II. --- Segmentation Tools --- p.11
Chapter 2.1. --- Segmentation of Object --- p.11
Chapter 2.1.1. --- Segmentation algorithm --- p.11
Chapter 2.1.2. --- Region growing algorithm --- p.16
Chapter 2.2. --- Noise Reduction --- p.19
Chapter 2.2.1. --- Median filtering --- p.19
Chapter 2.2.2 --- Mean filtering --- p.20
Chapter 2.3. --- Other functions --- p.21
Chapter 2.3.1. --- Contrast enhancement and reduction --- p.21
Chapter 2.3.2. --- Brightness increment and reduction --- p.22
Chapter III. --- 3D Visualization Tools --- p.23
Chapter 3.1. --- Interpolation --- p.23
Chapter 3.1.1. --- Estimate distance between slices --- p.23
Chapter 3.1.2. --- Trilinear Interpolation --- p.24
Chapter 3.2. --- Projection --- p.26
Chapter 3.2.1. --- Parallel projection --- p.26
Chapter 3.2.2. --- Z-Buffers --- p.27
Chapter 3.3. --- Rotation of 3D image --- p.29
Chapter 3.4. --- Shading --- p.30
Chapter IV. --- Description of the software developed --- p.32
Chapter 4.1. --- Programming environment --- p.32
Chapter 4.2. --- Software developed --- p.32
Chapter 4.3. --- 2D object segmentation panel --- p.35
Chapter 4.4. --- 3D object segmentation panel --- p.45
Chapter V. --- Results and analysis --- p.56
Chapter 5.1. --- Results of segmentation of object --- p.56
Chapter 5.2. --- Results of 3D visualization tools --- p.64
Chapter VI. --- Future Development --- p.70
Chapter VII. --- Conclusion --- p.72
References --- p.73
"Interactive Volumetric Holographic Display of Medical Images for Radiotherapy Treatment." 2016. http://repository.lib.cuhk.edu.hk/en/item/cuhk-1292320.
Full text本文提出了針對放射治療的互動式全息圖像顯示系統。系統硬體是一個簡單的全息顯示系統,稱為四側全息顯示系統。該軟體由兩部分組成。第一部分用於轉換BEV圖像和驅動全息顯示系統。它被專為規劃的胸部和頭部放射治療。第二部分用於胃鏡檢查影像處理。它結合了一系列的胃鏡檢查影像,以形成一個全景圖像,然後,生成全息顯示的視圖。它可以用於協助診斷胃腸道(GI)上呼吸道。他們都有互動式控制功能,如放大,縮小,放大和減少,以及旋轉。它與現有的醫學成像系統相比,具有兩個明顯的特徵。首先,它可以顯示醫學圖像三維結構化。其結果是,它能給醫療專業人員明確的視圖,可以進行診斷和放射治療計畫。第二,它是簡單和便宜。其互動功能是簡單的使用。隨著進一步發展,預計新系統很快就會在醫院發現實際應用。
In the past three decades, medical imaging is increasingly used in clinic around the world. One of the most commonly used medical imaging systems is called Beam’s Eye View (BEV). It reconstructs a 3D image from a serial of composite images of both Computed Tomography (CT) and Magnetic Resonance Imaging (MRI). It helps radiologists to plan radiotherapy treatment for cancer patients. While it is effective, the display of 3D images on a 2D flat screen often creates confusion and limits its effectiveness. The other system is the Eclipse Treatment Planning System. Eclipse is designed to increase productivity and provide some interactive functions. Radiologists are required to specify different organs manually slide by slide to generate 3D images. The most comprehensive radiotherapy treatment planning and simulation system is VERT. It provides platform for supplying radiation therapy training. Students can learn theoretical concepts of radiation therapy and practice set up and technique. This expensive system has a powerful interactive 3D display that can show life size CT and MRI images. However, it requires to use 3D gaggles and its 3D projection is sometimes inaccurate.
This thesis presents an interactive volumetric image display system for medical diagnosis and radiotherapy treatment. The system hardware is a simple holographic display system, called the four-side volumetric holographic display system. The software consists of two parts. The first part is used to convert the BEV images and drive the holographic display system. It is designed for planning radiotherapy treatment of chest and head. The second part is used to deal with gastroscopy images. It combines a series of gastroscopy images to form a panoramic image and then, generates the views for holographic display. It can be used for assisting the diagnosis of upper Gastrointestinal (GI) tract. They both have interactive control functions, such as zoom-in, zoom-out, enlarge and reduce, as well as rotate. Comparing to the existing medical imaging systems, it has two distinct features. First, it can display the medical images in a 3D structured manner. As a result, it gives unambiguous view based on which medical professionals can carry on diagnosis and plan for radiotherapy treatment. Second, it is simple and inexpensive. Its interactive functions are straightforward to use. With further development, it is expected that the new system will find practical applications in hospitals soon.
Lu, Yuk Ying.
Thesis M.Phil. Chinese University of Hong Kong 2016.
Includes bibliographical references (leaves ).
Abstracts also in Chinese.
Title from PDF title page (viewed on …).
Detailed summary in vernacular field only.
Detailed summary in vernacular field only.
Lai, Ying-Syuan, and 賴映瑄. "Design Annotation and Markup Display Consistent Web Solutionfor Medical Images." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/27133820297589046362.
Full text慈濟大學
醫學資訊學系碩士班
101
Medical imaging plays an important role in helping physicians diagnose and treat diseases. When physicians exam medical imaging and write diagnosis report, physicians often need to make annotations on medical images that correspond to the abnormal findings. We wish the images and annotations can be presented on PACS viewer automatically and consistently for helping another reviewers to exam the findings. However, it is not an easy task to share the annotations across medical image systems. Although DICOM has defined a standard (DICOM Presentation state object) for handling image annotations. However, the specifications are very sophisticate and lots of commercial PACS doesn’t support the specifications. Consequently, the image annotations can’t be exchanged and presented in other PACS systems. This research try to find another solution for sharing image annotations and defined a web based Annotation Image Markup specification. This research use the HTML5 Canvas and SVG (Scalable Vector Graphics) graphics templates for presenting medical imaging and marking annotations. We build a system to convert image annotations generated from conventional PACS systems to the SVG formatted annotations. Consequently, both the annotation generated from conventional PACSs or our system can be presented on the web solution. So the image annotated results will not limited in the execution environment, the result can be presented simply using internet browsers. And the web solution with SVG formatted annotations would be much more convenience for further used in clinical research and analysis than sophisticated DICOM presentation objects that stored in PACS.
Chang, Chin-Chin, and 張晉欽. "Preliminary Study of Compact and Portable Medical Image Display System." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/81194124342885122923.
Full text中原大學
電機工程研究所
89
In recent age, the rapid development of medical engineering, and more and more people put in this field, the direction of medical instrument design become more light and portable, but in some medical image display instrument just like PACS(Picture Archiving and Communication System), the PACS volume still large-sized. The developed system hope to combines the advantages of light-LCD display technique and Ethernet transfer system which have the characteristics of the small volume, portable, powerful quality and add other device, like Touch panel, Compact Flash memory, an 4-channel 10-bit resolution analog-to-digital converter(ADC7777). the system chip and device also the new products with new low power consumption technique, the design of the system is want to have qualities of low power, small volume, light-weight, and portable. The main purpose of this research is wanted to develop a multi-function medical image display system with light-LCD display technique, combine the multi-advantages and multi-functions, expect to research a system can use in the clinical environments popularly, and hope to make the system to be a resilience, low cost, low power, consumption and high memory medical display image system.
Yang, Ting-Wei, and 楊廷偉. "The Display of Medical Signals and Information and Their Applications." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/59855799323075028355.
Full text國立成功大學
電腦與通信工程研究所
95
We design and implement a contour-based 3D reconstruction system to help users reconstruct 3D objects. Besides, we develop a virtual reality navigation system in human body. Users can navigate the human body and learn some medical knowledge. To reconstruct 3D objects, we present a contour-based 3D reconstruct algorithm. We display the results and evaluate the algorithm. Our purpose is to make the 3D objects more similar to the real world. We also design and implement some tools to manipulate 3D objects and make measurements of the 3D objects. Users can use the system to read a series of human cross-sectional image files and draw the contours of the organs in the images to reconstruct the 3D objects. Therefore, we can obtain 3D human organ models. The 3D models can be used for the 3D scene of the navigation system. In the system, users can navigate through the human body with some simple man-machine interfaces. Besides, we also provide some medical knowledge such as the 2D cross-sectional images to the users while they are navigating so that the users will not get dis-oriented.
Chen, Fwn-Jeng, and 陳福政. "Medical Image Analysis, Fusion and Display for Multi-Modality Brain Images." Thesis, 1998. http://ndltd.ncl.edu.tw/handle/99173008316124701957.
Full text國立成功大學
資訊工程學系
86
In recent years, the increase in aging population, traffic and factoryaccidents has multiplied the numbers of cases in brain diseases anddamages. Therefore, the quality for brain diagnosis needs to beimproved by using the newly developed medical imaging devices urgently.A system integrates the information of multi- image modalities will behelpful for physicians to diagnose.The thesis includes two topics. The first topic is to develop a displaymethod, bulls-eye map, to show the quantitative analysis of the distribution of Tc-99m HMPAO in cerebral cortex. The brain lesion can be detected easily by the use of bulls-eye display. In order to understand the geometrical position of the lesion, the brain lesion and the outer skull obtained from MR brain images are combined and then displayed by the semi- boundary surface rendering technique. The second topic is to reconstruct the brain vessels in MRA images by use of a tracking method. The vessels and the outer skull in MRA brain images are also combined and then displayed to analyze morphology of 3-Dblood vessel trees.In order to develop the bulls-eye map, the two-staged thresholdingalgorithm and the distance transformation method are adopted to extractthe outer contour of the cerebral cortex. Then, the cerebral cortex can be determined according to a specific thickness value given by the physician. The intensity information in cerebral cortex will be translated into the bulls-eye map. The color of the bulls-eye plot is set according!to the ratio of the radioactivities in cerebral cortex to the radioactivities in the reference regions, including cerebellar and occipital cortex. In the method to reconstruct the three dimensional vessels, the urchin model is proposed to track the vessel region. The behaviors of the urchin including pinpricks growing, translation, and sub-urchin generation are designed and implemented in the proposed algorithm. Some rules and techniques are also provided to remove the ooises and to connect these vessels.Finally, some real cases are used in our experiments. The images from different modalities can be integrated with the proposed image processing and visualization techniques, and can be measured quantitatively for clinical evaluation.
YANG, HONG-ZHANG, and 楊弘章. "A study on the reconstruction and display of 3D medical images." Thesis, 1987. http://ndltd.ncl.edu.tw/handle/72141352069404824220.
Full text