Relevant bibliographies by topics / Medical Biotechnology

Academic literature on the topic 'Medical Biotechnology'

Author: Grafiati
Published: 4 June 2021
Last updated: 30 July 2024

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Journal articles on the topic "Medical Biotechnology"

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Yaseen, Arshed H., Halah M. H. Al-Hasani, and Umer Abdullah Ahmed Alelyan. "Biotechnology for medical diagnosis." Drug and Pharmaceutical Science Archives 02, no. 01 (2022): 01–05. http://dx.doi.org/10.47587/dpsa.2022.2101.

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Biotechnology is broadly defined as, “using organisms or their products for commercial purposes” encompasses a wide range. Since the beginning of time, people have used (traditional) biotechnology. Wheat, brew alcohol, and breed food crops and domestic animals have all been made using this grain. Molecular biology’s most recent breakthroughs, on the other hand, have given new life to biotechnology’s relevance and potential. Biotechnology has become a hot topic among the general public. There’s a good chance that modern biotechnology will have a big impact on the environment. Small-molecule (chemical) medications produced by well-known pharmaceutical companies have traditionally accounted for the vast majority of human illness treatments. The current article discussed.
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Pillai, D. R. "Medical Biotechnology." Clinical Infectious Diseases 59, no. 8 (June 27, 2014): 1201–2. http://dx.doi.org/10.1093/cid/ciu510.

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de Lange, Catherine. "Insider: Medical biotechnology." New Scientist 206, no. 2754 (March 2010): 44–45. http://dx.doi.org/10.1016/s0262-4079(10)60809-3.

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Sáenz, Tirso W. "Biotechnology for Medical Applications." Science, Technology and Society 10, no. 2 (September 2005): 225–48. http://dx.doi.org/10.1177/097172180501000203.

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Ivanov, I. "Pharmaceutical and Medical Biotechnology." Biotechnology & Biotechnological Equipment 21, no. 1 (January 2007): 74–79. http://dx.doi.org/10.1080/13102818.2007.10817418.

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Fontanarosa, Phil B., and Catherine D. DeAngelis. "Medical Applications of Biotechnology." JAMA 291, no. 8 (February 25, 2004): 1003. http://dx.doi.org/10.1001/jama.291.8.1003.

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Fontanarosa, Phil B. "Medical Applications of Biotechnology." JAMA 293, no. 7 (February 16, 2005): 866. http://dx.doi.org/10.1001/jama.293.7.866.

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Verjan García, Noel. "Biotechnology, powerful tools for research and development." Orinoquia 13, no. 1 (January 1, 2009): 2. http://dx.doi.org/10.22579/20112629.217.

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ABSTRACT: The concept of biotechnology has been in the human mind since very ancient times, when the first human beings discovered the production of wine by fermenting fruit juices, the brewing beer industry, and the conversion of milk into cheese or yogurt. However, as these basic processes have going through a wide range of developments to supply specific requirements, biotechnology has evolved and some of its most dramatic advances were observed during in the last 30-years. Modern biotechnology begins with the ability to transfer a specific gene from one organism to another by using a set of genetic engineering techniques, thus recombinant DNA technology sparked an era o biotech revolution. This major achievement, together with the maintenance and growth of genetically uniform plant-and animal cell cultures increased dramatically the spectrum of biotechnology’s applications in disease prevention, treatment and quality of life.
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Guryev, Evgenii L., Samah Shanwar, Andrei Vasilevich Zvyagin, Sergey M. Deyev, and Irina V. Balalaeva. "Photoluminescent Nanomaterials for Medical Biotechnology." Acta Naturae 13, no. 2 (July 27, 2021): 16–31. http://dx.doi.org/10.32607/actanaturae.11180.

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Creation of various photoluminescent nanomaterials has significantly expanded the arsenal of approaches used in modern biomedicine. Their unique photophysical properties can significantly improve the sensitivity and specificity of diagnostic methods, increase therapy effectiveness, and make a theranostic approach to treatment possible through the application of nanoparticle conjugates with functional macromolecules. The most widely used nanomaterials to date are semiconductor quantum dots; gold nanoclusters; carbon dots; nanodiamonds; semiconductor porous silicon; and up-conversion nanoparticles. This paper considers the promising groups of photoluminescent nanomaterials that can be used in medical biotechnology: in particular, for devising agents for optical diagnostic methods, sensorics, and various types of therapy.
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Yakovlev, A. Yu, A. A. Kruglikova, and S. I. Chernysh. "Calliphoridae Flies in Medical Biotechnology." Entomological Review 99, no. 3 (June 2019): 292–301. http://dx.doi.org/10.1134/s0013873819030023.

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Dissertations / Theses on the topic "Medical Biotechnology"

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Malindi, Zaria. "Photoimmunotheranostic targeting of CSPG4-positive melanoma cells using SNAP-tag technology." Master's thesis, Faculty of Health Sciences, 2018. http://hdl.handle.net/11427/31064.

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Melanoma is one of the most aggressive and inherently resistant cancers and the most dangerous skin cancer. While it accounts for fewer than 5% of skin cancer cases, 80% of skin cancer related deaths are attributed to melanoma. While resection remains the gold standard for melanoma treatment, surgery is only effective in providing local control of the disease if the cancer is detected in the early stages. Once melanoma enters the later stages, and particularly in the metastatic phase, recurrence is probable, and no adequate treatment exists. Previous work in this group has shown that photodynamic therapy (PDT) presents an opportunity to induce cell death in melanoma cells through the production of ROS and singlet oxygen at doses high enough to overwhelm the resistance mechanisms of the cancer. In this study, we investigated the use of recombinant SNAP-tag-based antibody fusion proteins as a means of delivering phototoxic molecules directly to cancer cells expressing the CSPG4 and PD-L1 cell surface receptors. SNAP-tag is an engineered version of the human DNA repair enzyme O6-alkylguanine-DNA alkyltransferase. It reacts autocatalytically and in a strictly 1:1 coupling chemistry with substrates that have been modified with benzylguanine (BG). Through genetic fusion of this self-labelling protein with a tumour targeting antibody, we developed a recombinant immunoconjugate able to carry BG-modified photosensitizers to selectively target and eliminate malignant melanoma cells. Conjugation of the SNAP-tag fusion protein with the fluorescent dye Alex Fluor 488 showed that anti-CSPG4-SNAP binds specifically to melanoma cells expressing the CSPG4 surface antigen. Binding was tested across a range of cell lines presenting melanoma in its radial and vertical growth phases, in the metastatic growth phase, in its chemoresistant form, and in both its pigmented and unpigmented forms. This binding data thus confirms CSPG4 as a suitable targeted for this treatment strategy. Conjugation of the fusion protein with the BGmodified photosensitizer IRDye 700DX (IR700) has produced no phototoxicity as of yet. In light of the convincing binding analysis, it is concluded that inefficient solubilization of the lyophilized product resulted in inadequate conjugation of BG-IR700 with SNAP-tag. Nonetheless, steps have been planned to resolve the problem in future ongoing work on this project, and we remain confident in the applicability of this technology. The results for the PD-L1 fusion protein were inconclusive. In summary, SNAP-tag technology offers a simple and efficient method for immunofluorescent detection of cancerous cells. These fusions proteins are versatile as they 1) can contain any antibody targeting a tumour-associated or tumour-specific antigen of choice and 2) can be endowed with a wide variety of substrates, as long as the latter contains the BG moiety.
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Jordaan, Donrich W. "Medical biotechnology law in South Africa : a human rights analysis of selected topics." Doctoral thesis, University of Cape Town, 2012. http://hdl.handle.net/11427/13868.

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In this thesis I analyse the human rights dimensions of the South African law on four topical medical biotechnology subjects, namely human embryo research, the use of human gametes, autologous tem cell therapy, and private stem cell banking. In all four cases, my analyses give specific prominence to two research themes: first, human dignity as touchstone of the South African human rights regime, and secondly legal certainly. The analyses show that the legal rules governing three of the four selected medical biotechnology subjects are not aligned with the country's human rights regime.
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Ramsin, Chelsea, Johanna Lidman, Frida Boström, Vendela Andersson, Sigrid Mack, Per Lindbom, and Zad Elnaz Samadian. "Development of sensitive and rapid cancer diagnostic assyas." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-412138.

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Brunet, Nicolas. "Study of a valorisation process for biomass industrial waste involving acid cooking and enzymatic hydrolysis." Thesis, KTH, Skolan för kemi, bioteknologi och hälsa (CBH), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-278738.

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Lignocellulosic biomass has potential to chip in the chemical and biofuels supplies in future societies,even though lignocellulose is a recalcitrant structure that has to be treated in several steps. After theirproper life cycle, wood-derived materials such as particleboards have few outcomes today apart fromenergy recovery for heat production. Then, they may be used as lignocellulosic biomass sources in theproduction of molecules of interest. Fermentation from wood-derived monosaccharides imposespreliminary sugar retrieval, for instance through pre-treatment and enzymatic hydrolysis. This studyfocuses on the potential of particleboards waste for chemical and biofuel production by comparingsaccharification through simulated steam explosion pre-treatment and enzymatic hydrolysis betweennative and particleboard-derived wood, with an insight in subsequent fermentation by Saccharomycescerevisiae. Urea-Formaldehyde bound particleboard was investigated, as well as some aspects ofMelamine-Urea-Formaldehyde bound particleboard. Pre-treatment resulted in apparition of lignocellulosic degraded compounds in a much larger extent innative wood than in particleboard, which seemed to be only superficially impacted. Formation ofdegraded compounds from sugars – furfural and 5-hydroxymethylfurfural – was enhanced when pretreatmentwas prolonged. Removal of a substantial fraction of the adhesive contained in theparticleboards was observed, leading to comparable concentrations in free urea, its degradedproducts, and formaldehyde between native wood and particleboards during enzymatic hydrolysis.Enzymatic hydrolysis with cellulases and hemicellulases highlighted a critical role of pre-treatment toenhance final yields, both in native wood and in Urea-Formaldehyde particleboard. Adding 20 minutessteam-explosion type pre-treatment at 160 °C resulted in glucose yields increase from 18.5 % to 32.8% for native wood and from 15.6 % to 37.4 % for particleboard. Prolonging pre-treatment residencetime to 35 minutes resulted in much better glucose extraction for native wood but only slight progressfor the particleboard, as glucose yields reached 64.5 % and 41.1 % respectively. Maximalconcentrations achieved were 277 and 184 mg/gbiomass respectively. Fermentation brought to light high inhibition from both native wood and particleboard sources ofmedia, which were attributed to components or degraded products of lignocellulose that were notanalysed in this project. Ethanol was formed during fermentation, with reduced productivity butincreased yields as compared with the control sample. Inhibition was so strong that no difference couldbe given between native and particleboard wood. In this situation, no inhibition potential of resin orits degradation products could be proved.
Lignocellulosic biomassa har potential att bidra till kemikalier och biobränsletillförsel i framtidasamhällen, trots att lignocellulosa är en rekalcitrant struktur som måste behandlas i flera steg. Idagträmaterial som spånskivor bara används för energiåtervinning och värmeproduktion efter deraslivscykel. De kan därför användas som råvara för framställning av värdefulla molekyler.Fermenteringsprocesser behöver frisättningen av trä monosackarider genom förbehandlingsprocesseroch enzymatisk hydrolys. Studien fokuserar på potentialen för avfall från spånskivor för kemisk ochbiobränsleproduktion. Vi har jämfört sackarifiering mellan nativt trä och spånskivor genom simuleradångaxplosion och enzymatisk hydrolys, med en inblick i efterföljande fermentering av Saccharomycescerevisiae. Spånskivor bunden av urea-formaldehyd undersöktes, liksom vissa aspekter av spånskivorbundna med melamin-urea-formaldehyd. Förbehandlingen producerade högre koncentration av lignocellulosa nedbrytningsprodukter frånnativt trä jämfört med spånskivor. Bildningen av nedbrytningsprodukter från sockerarter - furfural och5-hydroxymethylfurfural - ökade med längre förbehandlingar. En väsentlig fraktion av limmet borttogsfrån spånskivorna, vilket ledde till jämförbara koncentrationer i fri urea, dess nedbrytningsprodukteroch formaldehyd mellan naturligt trä och spånskivor under enzymatisk hydrolys. Enzymatisk hydrolys med cellulaser och hemicellulaser avslöjade den kritiska rollen av förbehandlingför att förbättra utbytet, både i naturligt trä och i urea-formaldehyd spånskiva. Längre (20 minuter)ångexplosion vid 160° C resulterade i högre glukosutbytet (från 18,5% till 32,8% för naturligt trä ochfrån 15,6% till 37,4% för spånskivor). Förlängning av uppehållstiden före behandlingen till 35 minuterresulterade i mycket bättre glukosekstraktion för nativt trä (64,5%) men endast liten framsteg förspånskivan (41,1%). Detta resulterade i maximalt utbyte av 277 mg Glc/g biomassa och 184 mg Glc/ gbiomassa för nativt trä och spånskivor, respektive. Fermentering visade hög hämning från lignocellulosa nedbrytningsprodukter som inte analyserades iprojektet för både nativt trä och spånskällor för media. Etanol bildades under fermentering medreducerad produktivitet men ökade utbyten jämfört med kontrollprovet. Hämningen var så stark attingen skillnad kunde ges mellan naturligt trä och spånskivor. I denna situation kunde ingenhämningspotential för lim eller dess nedbrytningsprodukter bevisas.
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Abuamra, Ola A. E. "Effect of IL-6 modulation on feeding behaviour and learning and memory in the ventral hippocampus." Thesis, Högskolan i Skövde, Institutionen för biovetenskap, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-20507.

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In the last decades, the prevalence of obesity increased dramatically worldwide. According to the WHO, 2.1 billion people (30% of the population) around the world are obese or overweight. Effective ways to decrease food intake are needed. Evidence from emerging studies indicates an association between feeding behavior and the IL-6 expression in the central nervous system (CNS). The study aimed to investigate the effect of IL-6 modulation on feeding behavior and learning and memory process in the ventral hippocampus (vHPC). To implement this aim two groups of rats were used, the first group was exposed to the reduction of the IL-6 expression (knockdown), whereas the other one to microinjections of exogenous IL-6 (EX IL-6). Both experimental groups were subjected to a set of behavioral and molecular tests specific for investigating memory process, emotional/affective behavior and food intakes like novel object recognition, Morris water maze, and social interaction test. The results for IL-6 knockdown (KD) showed improvement in the short term memory, but did not affect the food intake. On the other hand, EX IL-6 caused an increase in the locomotor’s activity and the food intake during the 24 hours, but at the same time caused impairment in the spatial and learning memory. Taken together, these results provide new insight on the role of IL-6 outside of inflammation highlighting its ability to modulate hippocampus-dependent mnemonic process, and affective and feeding behaviors in the vHPC, however several questions still remain not addressed and the study require further investigation.
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Odén, Österbo Ina, Malin Åslund, Linnea Flinkfeldt, Josef Pelcman, Vilhelm Book, and Joakim Lindström. "Hur hittas HIV? : Två metodförslag för koncentrationsmätning av virioner i blodplasma." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-323192.

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Litteraturstudier har genomförts med syftet att utveckla minst en ny detektionsmetod som skulle kunna ersätta den metod som företaget Cavidi använder sig av idag. Cavidi hade specificerat krav som metodförslaget skulle uppfylla. Dessa krav var att metoden skulle vara snabb, lättanvänd, billig, ha hög känslighet och kunna förvaras i rumstemperatur. Två lovande metoder som baseras på två olika principer valdes ut. Den ena metoden bygger på att enkelsträngat DNA med en specifik nukleinsyrakomposition syntetiseras. Denna sekvens har egenskapen att spontant bilda en sekundärstruktur som kan bilda komplex med en fluorofor. Detta ökar dess fluorescens. Ökningen detekteras med fluorescensspektroskopi. Den andra metoden baseras på ett optomagnetiskt fenomen vilket innebär att ett magnetiskt fält påverkas av polariserat ljus. Metoden går ut på att virioner först renas fram från blodplasma och att de fäster på jonbytarkulor under rådande buffertförhållanden. Magnetiska nanopartiklar tillsätts som binder till jonbytarkulornas lediga ytor. Om många virioner har bundit till jonbytarkulorna finns det en större mängd fria nanopartiklar i lösningen. Antalet fria nanopartiklar i lösningen är proportionellt mot mängden HIV i provet och kan då detekteras med en fotodetektor. Fördelarna med dessa metoder är att processen blir billigare, snabbare och har en hög känslighet. Metoderna är lättanvända och använder färre komponenter jämfört med Cavidis nuvarande metod. Därmed blir Cavidis produkter billigare och tillgängliga för fler människor.
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Koller, Daniela. "Processing of Optical Coherence Tomography Images : Filtering and Segmentation of Pathological Thyroid Tissue." Thesis, Linköpings universitet, Institutionen för medicinsk teknik, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-161988.

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In the human body, the main function of the healthy thyroid gland is the regulation of the metabolism and hormone production. Included in the thyroid are organized structured and uniformly shaped follicles ranging from 50-500 μm in diameter. Pathologies lead to morphological changes of these follicles, affecting the density and size, but can also lead to an absence. In this study optical coherence tomography (OCT) was used to examine pathological thyroid tissue by extracting structural information of the follicles from image segmentation. However, OCT images usually include a high amount of speckle noise which affects the segmentation outcome. Due to that, the OCT images need to be improved. The aim of this thesis was to investigate the appropriate filtering methods to enhance the images and thus improve the segmentation outcome. The images of pathological thyroid tissues with a size of 0:5-1 cm where scanned by a spectral domain OCT system (Telesto II, Thorlabs GmbH, Germany) using a center wavelength of 1300nm. The obtained 2D and 3D images were saved as .oct file as well as implemented and visualized in a MATLAB graphical user interface (GUI) for further processing. For image improvement, four filtering enhancement methods were applied to the 2D images such as the enhanced resolution imaging (ERI), adaptive Wiener filter, discrete wavelet transform (DWT) and multi-frame wavelet transform (WT). The processed images were further converted to grayscale and binary images for intensity-based segmentation. The output of all methods were compared and evaluated using signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), enhanced number of looks (ENL), edge profiles and outcome of the segmented images. It was demonstrated that the complex DWT (cDWT) with a higher threshold and the multi-frame WT using the haar wavelet showed enhanced results over the other filtering methods. The computed SNR could be increased up to 52% and the ENL value up to 4802%, applying the multi-frame WT, while the CNR could be increased up to 106% for cDWT. The lowest obtained gradient was equal to an intensity decrease of -61% and -68% for multi-frame WT and cDWT, respectively. The filtering method could increase the smoothness of the image while the edge sharpness could be kept. The segmentation could detect both small and large follicles. ERI did not show any improvement in the segmentation but could enhance the structural detail of the image. Larger neighbourhoods of the adaptive Wiener filter showed a highly blurred image and led to merged follicles in the image segmentation. The wavelet filters DWT and multi-frame WT gave most satisfying results since high and low frequencies were divided into subbands, where individual information on vertical, horizontal and diagonal edges was stored. Applied cDWT had an even higher amount of subbands, so that more information on signal and speckle noise could be specified. Due to this fact, it was possible to achieve a decreased noise level while edge sharpness where maintained. Using a multi-frame image an increased SNR was obtained, as the intensity information stayed constant over the individual frames while the noise information changed. Wavelet based filtering showed higher improved results in comparison to the adaptive Wiener filter or the ERI in the 2D domain. By applying filtering methods in higher dimensions such as 3D or even 4D, better results in noise reduction are expected. Improved settings for the individual filtering methods as well as enhancement in segmentation are part of the future work.
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Johansson, Hampus. "Nox2/4 inhibition in NB69 during ischemia/reperfusion : Inhibition of ROS-production using M4, M107, and M114." Thesis, Högskolan i Skövde, Institutionen för hälsa och lärande, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-17941.

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Cerebral stroke has become one of the leading causes of death and disability worldwide. During an ischemic stroke, oxygen and nutrient deprivation occurs, which combined lead to cell starvation, anoxia, and eventually cell death. However, when blood flow is restored, reperfusion damage occurs resulting in increased cell death through several mechanisms. One of the main reasons behind ischemia/reperfusion damage is oxidative stress due to elevated production of reactive oxygen species (ROS) during reperfusion. There are several proteins and processes that are thought to be involved in elevated oxidative stress and the formation of ROS during reperfusion, among which the NADPH oxidase (Nox) family is suggested to be the main contributor of ROS.To examine this hypothesis, in the present work, we inhibited activity of the Nox2 and Nox4 enzymes during ischemia/reperfusion with the Glucox Biotech AB (Sweden) inhibitors M4, M107, and M114 to evaluate whether reducing Nox activity could reduce the ischemia/reperfusion-induced cell death, hence be used as a potential stroke treatment, the cell viability was measured with MTS after ischemia/reperfusion induction and treatment with the Nox substances. We also examined the gene expression levels of the Nox enzymes Nox2 and Nox4 with qPCR after induced ischemia/reperfusion in the neuroblastoma cell line NB69.Our results showed a decrease in Nox4 gene expression after 1h ischemia/8h reperfusion and an increased expression after 1h ischemia/24h reperfusion in NB69 cells. Treatment with M114 resulted in increased cell viability after 2h ischemia/72h reperfusion. However, the toxic effect of ischemia/reperfusion-induced response was found to be inadequate, as indicated by extensive proliferation and lack of cell death. This unfavorable outcome is suggested to be excess of oxygen in medium, metabolization of L-glutamine, and effects of growth factors in the serum used in cell culture medium during the ischemic phase. Therefore, the cell culture protocol was modified to the use of PBS instead of glucose-free medium under serum-free condition during the ischemia. The altered ischemic conditions resulted in continuous reduction in cell viability at increasing ischemic time points with total cell death at 2h ischemia, suggesting applicable conditions for ischemia/reperfusion studies. Even though a conclusion could not be made about the inhibitors M4, M107, and M114 as the cell viability assay was performed under insufficient conditions; the Nox inhibitors shows high potential as future ischemic stroke treatments, which may help save lives and improve life quality for affected patients.
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Ramachandraiah, Harisha. "Microfluidic based isolation of circulating tumor cells from whole blood for cancer diagnostics." Doctoral thesis, KTH, Proteomik och nanobioteknologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-203889.

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Detection of circulating tumor cells (CTC) in peripheral blood is indicative of early recognition of tumor progression and such an important biomarker for early diagnosis, staging, monitoring and prognosis of cancer. However, CTC are found in very low concentrations and reliable isolation of these rare cells is challenging. Microfluidics enables precise manipulation of fluids and cells and is ideal for cell sorting methods for clinical diagnostics. The thesis contributes towards the development of microfluidic based CTC isolation methods from peripheral blood. The methods are based on size and immunoaffinity. The first part of the thesis describes the phenomenon of inertial focusing for size based cell separation at high throughputs. In paper 1, we demonstrate continuous filtration of leukocytes from diluted blood, with an efficiency of 78% at a flow rate of 2.2ml/min. In the paper 2, separation of total and subpopulation of leukocytes with a purity of 86% for granulocytes and 91% for lymphocytes is demonstrated. Furthermore, cancer cells spiked into whole blood could be separated at a yield of 88%. Finally, in paper 3 and 4 we unravel parts of the unexplored elasto-inertial microfluidics and was utilized to precisely focus the cells, as part of an integrated optofluidic micro flow cytometer device, capable to simultaneously measure fluorescence and scattering of cells and particles at a rate of 2500 particles/sec (paper 4). Second part of the thesis focuses on acoustophoresis. In (paper 5), a multifunctional acoustic microdevice was developed for isolation of cancer cells from red blood cells with a separation efficiency of 92.4% and trapping efficiency of 93%. In (paper 6), microbubbles activated acoustic cell sorter was developed for affinity based cell separation. As a proof of principle, cancer cells in a suspension were separated at an efficiency of 75%. In the third part, using cellulose nano fibrils (paper 7), we demonstrate efficiently capture and release of cancer cells at a release efficiency of 95%. Finally, a novel, single step self-assembly of spider silk proteins is introduced inside microfluidic channels for effective capture of cancer cells with 85% capture efficiency and subsequent release of captured cells with 95% release efficiency (paper 8). The novel recombinant silk modified microfluidic device was validated using pancreatic cancer patients. In summary, we have developed different microfluidic based isolation technologies for the capture and characterization of CTC.

QC 20170321

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Odell-West, Amanda. "Should the medical exclusion within patent law be amended or removed?" Thesis, University of Sheffield, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.606774.

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The main concern of this thesis is whether the medical exclusion in patent law should be retained unamended, redrafted or removed in light of the various legal problems and policy considerations. Income generation by NHS bodies is assuming increasing importance in the Department of Health. The IP strategy for the NHS launched in 2002 places a responsibility on NHS employees to generate and identify IP arising in the course of their duties. The Government may wish to consider removing the medical exclusion in the commercial interests of the country in accordance with its wider IP policy for public sector research establishments and its market-based reforms for the NHS.There are four key purposes of this thesis. The first is to establish the importance of the medical exclusion for doctors and their practice in terms of function and validity. The second is to ascertain the compatibility of the patent process with medical professionalism and tradition. The third is to investigate whether doctors think a specific category of medical method patents could be acceptable (in terms of medical practice) and fourthly, to ascertain the degree to which doctors think patents on gene-based diagnostic tests interfere with their practice, research and development. The empirical research reveals views from 275 NHS Trust consultants and GPs in Sheffield about the medical exclusion, a new substantial development criterion in patent law, the effects of the patent process on aspects of medical practice and the effects of patented genetic diagnostic test methods on medical research and practice. Analysis of the results reveals a number of disadvantages of the existing legal regime, which lead to proposals for reform.
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Books on the topic "Medical Biotechnology"

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author, Delovitch T. L., and Patten Cheryl L. author, eds. Medical biotechnology. Washington, DC: ASM Press, 2014.

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Bergstrom, Kimberly A., and Michael J. Schurr. Medical applications of biotechnology. Belmont, MA: CMR Institute, 2011.

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1959-, Guzman Carlos Alberto, and Feuerstein Giora Z. 1946-, eds. Pharmaceutical biotechnology. New York: Springer Science+Business Media, 2009.

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H, Bahl, and Dürre P, eds. Clostridia: Biotechnology and medical applications. Weinheim: Wiley-VCH, 2001.

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Anwar, Mumtaz, Riyaz Ahmad Rather, and Zeenat Farooq, eds. Fundamentals and Advances in Medical Biotechnology. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-98554-7.

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American Bar Association. Section of Science & Technology Law, ed. Medical biotechnology: Premarket and postmarket regulation. Chicago, Illinois: American Bar Association, Section of Science & Technology Law, 2015.

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Zehel, Wendell. Biotechnology: The physiologic and medical application. Pittsburgh, Pa: SterlingHouse, 2000.

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Inuwa, Hajiya Mairo, Ifeoma Maureen Ezeonu, Charles Oluwaseun Adetunji, Emmanuel Olufemi Ekundayo, Abubakar Gidado, Abdulrazak B. Ibrahim, and Benjamin Ewa Ubi. Medical Biotechnology, Biopharmaceutics, Forensic Science and Bioinformatics. Boca Raton: CRC Press, 2022. http://dx.doi.org/10.1201/9781003178903.

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Lee, Shui Chuen. The Family, Medical Decision-Making, and Biotechnology. Dordrecht: Springer Netherlands, 2007. http://dx.doi.org/10.1007/1-4020-5220-0.

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1940-, Khachatourians George G., and Arora Dilip K, eds. Applied mycology and biotechnology. Amsterdam: Elsevier, 2001.

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Book chapters on the topic "Medical Biotechnology"

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Khan, Firdos Alam. "Medical Biotechnology." In Biotechnology Fundamentals, 215–38. Third edition. | Boca Raton : CRC Press, 2020.: CRC Press, 2020. http://dx.doi.org/10.1201/9781003024750-9.

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Lohray, Braj B. "Medical Biotechnology in India." In Biotechnology in India II, 215–81. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/3-540-36466-8_7.

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Anwar, Mumtaz, Samia Rashid, and Zeenat Farooq. "Epigenetics and Medical Biotechnology." In Fundamentals and Advances in Medical Biotechnology, 209–31. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-98554-7_7.

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Ahmad, Aqeel, Prabjyot Jhatu, Ahmed Abu Fayyad, and Mohammad Tauseef. "Ethics and Medical Biotechnology." In Fundamentals and Advances in Medical Biotechnology, 419–28. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-98554-7_14.

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Ahmad, Zamin, Tariq Ahmad Shah, K. Pratap Reddy, Sudip Ghosh, Virendra Panpatil, Sandeep Kumar Kottoru, Sheikh Rayees, and D. Raghunatha Rao. "Immunology in Medical Biotechnology." In Fundamentals and Advances in Medical Biotechnology, 179–207. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-98554-7_6.

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Kolassa, Eugene M., and Tushar B. Padwal. "Economic Considerations in Medical Biotechnology." In Pharmaceutical Biotechnology, 237–45. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-6486-0_10.

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Patel, Amit S., and Kartick P. Shirur. "Economic Considerations in Medical Biotechnology." In Pharmaceutical Biotechnology, 253–63. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-00710-2_11.

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Patel, Amit S., and Kartick P. Shirur. "Economic Considerations in Medical Biotechnology." In Pharmaceutical Biotechnology, 255–65. Cham: Springer International Publishing, 2024. http://dx.doi.org/10.1007/978-3-031-30023-3_10.

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Wetzel, Gayle Delmonte. "Medical Applications of Recombinant Proteins in Humans and Animals." In Biotechnology, 125–88. Weinheim, Germany: Wiley-VCH Verlag GmbH, 2008. http://dx.doi.org/10.1002/9783527620869.ch5.

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Farooq, Zeenat, Samia Rashid, Safrun Mahmood, Akhtar Mahmood, and Mumtaz Anwar. "The Advent of Medical Biotechnology." In Fundamentals and Advances in Medical Biotechnology, 1–20. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-98554-7_1.

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Conference papers on the topic "Medical Biotechnology"

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Mak, Benjamin, Liam Birkett, Maurice Klee, Eoin Cunneen, and Alain Colombet. "Intellectual property in medical devices and biotechnology." In 2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 2007. http://dx.doi.org/10.1109/iembs.2007.4353308.

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Liu, Mujiexin, Dazheng Zhang, Danyi Wen, and Zhidong Jia. "A Medical Service Model Based on TCM Expertise to Ensure the Continuity of Medical Tour." In International Conference on Biotechnology and Biomedicine. SCITEPRESS - Science and Technology Publications, 2022. http://dx.doi.org/10.5220/0012019800003633.

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Titov, E. I. "BIOTECHNOLOGY OF BOVINE LACTOFERIN FOR MEDICAL AND DIETARY PURPOSE." In 17th International Multidisciplinary Scientific GeoConference SGEM2017. Stef92 Technology, 2017. http://dx.doi.org/10.5593/sgem2017/61/s25.073.

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"Changing risks with medical devices." In Technology for Life: North Carolina Symposium on Biotechnology and Bioinformatics - 2004. IEEE, 2004. http://dx.doi.org/10.1109/sbb.2004.1364369.

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Ding, Min. "Design of Medical Assistant Robot." In 2016 6th International Conference on Machinery, Materials, Environment, Biotechnology and Computer. Paris, France: Atlantis Press, 2016. http://dx.doi.org/10.2991/mmebc-16.2016.291.

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Negut, Irina, Carmen Ristoscu, Tatiana Tozar, V. Grumezescu, M. Dinu, A. C. Parau, Marcela Popa, and Maria-Magdalena Stan. "Bioactive glass coatings synthesized by “MAPLE” for enhanced performance of medical implants." In 5th International Scientific Conference on Microbial Biotechnology. Institute of Microbiology and Biotechnology, Republic of Moldova, 2011. http://dx.doi.org/10.52757/imb22.08.

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Fang, Jingfei, Jiajun Du, Hanlun Jiang, and Kailai Hu. "The Impact of Multiple Rounds of Covid-19 on Stock Market of China’s Medical Companies." In International Conference on Biotechnology and Biomedicine. SCITEPRESS - Science and Technology Publications, 2022. http://dx.doi.org/10.5220/0012032900003633.

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Love, Lonnie. "NVBL (National Virtual Biotechnology Laboratory) Advanced Manufacturing for Medical Supplies for COVID-19." In National Virtual Biotechnology Laboratory Symposium: Harnessing the unique strengths of DOE to tackle the biotechnology challenges of COVID-19, October 28, 2020. US DOE, 2020. http://dx.doi.org/10.2172/1718914.

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Siswati, Sri, Yolanda Safitri, and Elsa Giatri. "E-Health Implementation from a Medical Secret Angle." In 1st International Conference on Health Sciences and Biotechnology (ICHB 2021). Paris, France: Atlantis Press, 2022. http://dx.doi.org/10.2991/ahsr.k.220303.040.

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Castorena-Robles, A., N. K. Gamboa-Rosales, A. Faz-Mendoza, M. A. Casas-Valadez, C. E. Medina-Rodriguez, and J. R. Lopez-Robles. "Exploring the role of Medical Decision Making in Biotechnology field through science mapping." In 2020 International Conference on Decision Aid Sciences and Application (DASA). IEEE, 2020. http://dx.doi.org/10.1109/dasa51403.2020.9317023.

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Reports on the topic "Medical Biotechnology"

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Hyman, Cody, Henry Dao, Gregory Vaughan, and Fred D. Ledley. Implications of the Inflation Reduction Act for the biotechnology industry; sensitivity of investment and valuation to drug price indices and market conditions. Institute for New Economic Thinking Working Paper Series, June 2024. http://dx.doi.org/10.36687/inetwp223.

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Abstract:
The Inflation Reduction Act of 2022 contains landmark provisions authorizing the government to negotiate the price of selected drugs covered by Medicare Part D. The biopharmaceutical industry has criticized these provisions as a threat to innovation arguing that reducing future revenues could disincentivize equity investment in biotechnology. This research examines the sensitivity of private and public equity investment in the biotechnology industry to drug price indices and market conditions from 2000-2022. The analysis shows that equity financing and valuation in the biotechnology industry were strongly associated with equity market conditions but not indices of either producer or consumer drug prices. These results do not support claims of an association between changing drug prices and the availability of equity capital to emerging biotechnology companies, which currently sponsor the majority of all clinical trials. These results add to evidence that the IRA may not have a negative impact on pharmaceutical innovation.
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