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Books on the topic 'Mediator’s action'

Author: Grafiati

Published: 23 September 2022

Last updated: 27 January 2023

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1

Sven-Erik, Dahlén, ed. Leukotrienes as mediators of asthma and inflammation: Basic and applied research, second International Symposium on Trends in Eicosanoid Biology, Interlaken, Switzerland. New York: Raven Press, 1994.

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2

International, Conference on Oxygen and Life (3rd 2000 Kyoto Japan). Oxygen and life: Oxygenases, oxidases, and lipid mediators : proceedings of the 3rd International Conference on Oxygen and Life which was held in Kyoto, between 26 and 29 November 2000. Amsterdam: Elsevier, 2002.

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3

Cabannes, Yves, Mike Douglass, and Rita Padawangi, eds. Cities in Asia by and for the People. NL Amsterdam: Amsterdam University Press, 2018. http://dx.doi.org/10.5117/9789462985223.

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This book examines the active role of urban citizens in constructing alternative urban spaces as tangible resistance towards capitalist production of urban spaces that continue to encroach various neighborhoods, lanes, commons, public land and other spaces of community life and livelihoods. The collection of narratives presented here brings together research from ten different Asian cities and re-theorises the city from the perspective of ordinary people facing moments of crisis, contestations, and cooperative quests to create alternative spaces to those being produced under prevailing urban processes. The chapters accent the exercise of human agency through daily practices in the production of urban space and the intention is not one of creating a romantic or utopian vision of what a city "by and for the people" ought to be. Rather, it is to place people in the centre as mediators of city-making with discontents about current conditions and desires for a better life.

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4

Schror, Karsten. Mediators in the Cardiovascular System: Regional Ischemia (Agents and Actions Supplements). Birkhauser, 1995.

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5

Mediators in the Cardiovascular System: Regional Ischemia (Agents and Actions Supplements). Birkhauser, 1994.

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6

Fonteh, Alfred N., and Robert L. Wykle. Arachidonate Remodeling and Inflammation. Birkhäuser Boston, 2012.

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7

Fonteh, Alfred N., and Robert L. Wykle. Arachidonate Remodeling and Inflammation. Birkhauser Verlag, 2012.

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8

(Editor), Alfred N. Fonteh, and Robert L. Wykle (Editor), eds. Arachidonate Remodeling and Inflammation (Progress in Inflammation Research). Birkhäuser Basel, 2004.

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9

G, Goldie R., and Hay, Douglas W. P., 1956-, eds. Pulmonary actions of the endothelins. Basel: Birkhüser Verlag, 1999.

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10

Ackermann and Welton. Progress in Inflammation (Agents and Actions Supplements). Birkhauser, 1991.

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11

Muthukumar, Thangamani, Darshana Dadhania, Choli Hartono, and Manikkam Suthanthiran. Immunology, sensitization, and histocompatibility. Edited by Jeremy R. Chapman. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0279.

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Allograft rejection of the histo-incompatible allograft involves a highly orchestrated action of multiple cell types and mediators, with lymphocytes responsible for the identification of the foreignness of the allograft. The immune response directed against the donor is primarily, but not exclusively, directed at the donor’s major histocompatibility complex region class I and class II proteins. This chapter describes the immunobiology of the T cell and the role of human leucocyte antigens in clinical transplantation, thus identifying the targets for manipulation of the immune response by immune suppressants and through strategies designed to create a state of tolerance of the allograft.

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12

Haq, Khadija, ed. UNCTAD VII. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780199474684.003.0019.

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In this chapter, Haq expresses deep concern for UNCTAD as an organization. He explains how UNCTAD became more of a partisan secretariat for developing countries rather than fulfilling its role as the mediator between developed and developing countries. Both sets of countries wrongly employed UNCTAD as a forum for debates rather than meaningful negotiation. Haq, in this piece, outlines key areas for action that can help make UNCTAD a more effective organization.

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13

Hedqvist, Per, Sven-Erik Dahlen, and Bengt Samuelsson. Leukotrienes As Mediators of Asthma and Inflammation: Basic and Applied Research (Advances in Prostaglandin, Thromboxane, and Leukotriene Research). Lippincott Williams & Wilkins, 1995.

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14

Morgan, D. W., R. J. Booney, and Niall S. Doherty. Inflammatory Disease Therapy: Preclinical and Clinical Developments (Agents and Actions Supplements). Birkhauser, 1993.

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15

Henry, Laura A., and Lisa McIntosh Sundstrom. Bringing Global Governance Home. Oxford University Press, 2021. http://dx.doi.org/10.1093/oso/9780197530238.001.0001.

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The world’s problems are increasingly global in scale. Climate change, pandemics, and the actions of multinational corporations are all beyond the ability of any single state to address. States and civil society actors have joined a growing number of global governance institutions to address these challenges collectively. While global governance is initiated at the international level, the effects of global governance occur at the domestic level and depend upon the actions of domestic actors. NGOs act as “mediators” between global and domestic political arenas, translating and adapting global norms for audiences at home. However, NGO participation in global governance varies significantly by country and by issue area. The role of domestic NGOs in global governance has been relatively neglected—a puzzling gap since domestic implementation determines whether global “best practices” are applied for the common good or languish as words on the pages of international reports. The BRICS states (Brazil, Russia, India, China, and South Africa) offer excellent cases for delving into contention around NGOs’ role as mediators due to their shared aspiration to shape global governance and their varied political and economic characteristics. Bringing Global Governance Home: NGO Mediation in the BRICS States fills gaps in our knowledge by identifying and explaining significant cross-national variation in NGO participation in global governance based on an original dataset. Moreover, it combines insights from international relations and comparative politics to explain the dilemmas and strategies of NGO mediation in case studies on HIV/AIDS, climate change, sustainable forestry, and corporate social responsibility.

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16

Studies on the mechanism of action of "new pressor protein": Bradykinin, pituitary adenylate cyclase-activating polypeptide and adrenal catecholamines as possible mediators of its cardiovascular effects. Ottawa: National Library of Canada, 2001.

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17

Menary, Richard. Keeping Track with Things. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198769811.003.0016.

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The chapter begins with an evolutionary account of tracking systems, from simple detection systems to complex decoupled and highly flexible tracking systems. The important mediator is the role of the environment in providing the complexity, translucency, and hostility that produces the evolutionary pressures that result in more complex tracking systems. An evolutionary platform is provided for how modern humans could have come to innovate epistemic tracking tools (ETTs) for keeping track of salient features of the environment. Three examples of ETTs in action are given, ranging from highly iconic and contextual learning tools—such as the Mattang—to highly abstract and decoupled conventional symbol systems. Finally, it is argued that ETTs are compatible with a responsibilist-reliabilism since their correct deployment requires epistemic diligence and the reliable functioning of the tool itself. As such, a framework for understanding and exploring how we keep track with things has been given.

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18

Murphy, Patrick D. Conclusion. University of Illinois Press, 2017. http://dx.doi.org/10.5406/illinois/9780252041037.003.0007.

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The conclusion digests the main issues explored in the previous chapters. The core argument put forward is that the global media landscape that materialized at the end of the twentieth century has become a central mediator of eco-consciousness around the globe. This landscape is defined primary by the Promethean discourse, which assumes that growth is perpetual and that individuals operating within the market have the agency to solve any and all environmental problems. This discourse is problematic when considered in the face of anthropogenic climate change and declining natural resource reserves. However, even powerful discourses co-produced and are hence not immune to challenges. This means that alternative environmental discourses can be found within market driven media, suggesting that while the contemporary media commons is the domain of non-ecologically responsive normative trends, its also offers openings for more progressive environmental thought and action.

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19

Schaafsma, Polly. North America—Southwest. Edited by Timothy Insoll. Oxford University Press, 2017. http://dx.doi.org/10.1093/oxfordhb/9780199675616.013.016.

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This broad overview considers the long discontinuous and diverse history of anthropomorphic figurine production in the ancient American Southwest. While the primary focus is on the Hohokam, Fremont, and Ancestral Pueblos, other cultural contexts are considered. Numerous figurine styles are described, as are close stylistic relationships between certain figurine traditions and rock art. Stylistic trends in the graphic rock art may have influenced the aesthetics of figurine production and vice versa. Discarded in refuse mounds, cached in association with burials and cremations or in crypts within architectural confines, figurines and their roles were diverse between cultures and changed through time. Regarded as active agents within their respective cultural frameworks, the chapter proposes that they functioned as social mediators, promoted fertility, increase, and community well-being, and as they served as conduits to the ancestors and cosmological entities.

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20

Hughes, Jeremy. Proteinuria as a direct cause of progression. Edited by David J. Goldsmith. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0137.

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Proximal tubular cells reabsorb any filtered proteins during health via cell surface receptors such as megalin and cubulin so that very low levels of protein are present in the excreted urine. Significant proteinuria is a common finding in patients with many renal diseases. Proteinuria is a marker of glomerular damage and podocyte loss and injury in particular. The degree of proteinuria at presentation or during the course of the disease correlates with long-term outcome in many renal diseases. Proteinuria per se may be nephrotoxic and thus directly relevant to the progression of renal disease rather than simply acting as a marker of the severity of glomerular injury and podocytes loss. Seminal studies used the atypical renal anatomy of the axolotl to instill proteins directly into the tubular lumen without requiring passage through the glomerulus. This indicated that tubular protein could be cytotoxic and induce interstitial inflammation and fibrosis in the peritubular region. Cell culture studies demonstrate that exposure to proteins results in proximal tubular cell activation and the production of pro-inflammatory and pro-fibrotic mediators. Proximal tubular cell death occurred in some studies reinforcing the potential of protein to exert cytotoxic effects via oxidative stress or endoplasmic reticulum stress. Analysis of renal biopsy material from both experimental studies using models of proteinuric disease or patients with various proteinuric diseases provided evidence of activation of transcription factors and production of chemokines and pro-inflammatory mediators by proximal tubular cells. These data strongly suggest that although proteinuria is the result of glomerular disease it also represents an important cause of progression in patients with chronic kidney disease associated with proteinuria.

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21

Hanahan, Donald J. A Guide to Phospholipid Chemistry. Oxford University Press, 1997. http://dx.doi.org/10.1093/oso/9780195079814.001.0001.

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This book provides a concise introduction to phospholipid chemistry and is intended for a broad audience of biologists, biochemists, and graduate students. Developed as part of a graduate course on lipids, this book also serves as a reference for laboratory investigators on signal transduction and biological membranes. The first part of the text is devoted to an orientation to the chemical nature of lipids in general, how they are thought to be associated in the cell, and the methodology by which the cellular lipids (including the phospholipids) can be recovered from cells and subjected to an initial identification. Subsequent chapters characterize the choline-containing phospholipids, including the sphingolipids, the non-choline containing phospholipids, and finally, the so-called minor phospholipids. The latter compounds, which act as agonists or lipid chemical mediators on cells, form a vanguard of a new category of biologically active substances and have set the study of cellular phospholipids on a new and exiting course. Most importantly, this book provides a basis for further inquiry on these complicated molecules, showing that although the compounds are unique, with care and understanding, they can be studied with ease

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22

Schaible, Hans-Georg, and Rainer H. Straub. Pain neurophysiology. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0059.

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Physiological pain is evoked by intense (noxious) stimuli acting on healthy tissue functioning as a warning signal to avoid damage of the tissue. In contrast, pathophysiological pain is present in the course of disease, and it is often elicited by low-intensity stimulation or occurs even as resting pain. Causes of pathophysiological pain are either inflammation or injury causing pathophysiological nociceptive pain or damage to nerve cells evoking neuropathic pain. The major peripheral neuronal mechanism of pathophysiological nociceptive pain is the sensitization of peripheral nociceptors for mechanical, thermal and chemical stimuli; the major peripheral mechanism of neuropathic pain is the generation of ectopic discharges in injured nerve fibres. These phenomena are created by changes of ion channels in the neurons, e.g. by the influence of inflammatory mediators or growth factors. Both peripheral sensitization and ectopic discharges can evoke the development of hyperexcitability of central nociceptive pathways, called central sensitization, which amplifies the nociceptive processing. Central sensitization is caused by changes of the synaptic processing, in which glial cell activation also plays an important role. Endogenous inhibitory neuronal systems may reduce pain but some types of pain are characterized by the loss of inhibitory neural function. In addition to their role in pain generation, nociceptive afferents and the spinal cord can further enhance the inflammatory process by the release of neuropeptides into the innervated tissue and by activation of sympathetic efferent fibres. However, in inflamed tissue the innervation is remodelled by repellent factors, in particular with a loss of sympathetic nerve fibres.

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23

Sedek, Grzegorz, Thomas Hess, and Dayna Touron, eds. Multiple Pathways of Cognitive Aging. Oxford University Press, 2021. http://dx.doi.org/10.1093/oso/9780197528976.001.0001.

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The study of aging and cognition has grown tremendously over the past 50 years, developing from a field dominated by experimentally based information-processing traditions to one represented by a more mature approach both conceptually and methodologically. A quick examination of relevant research over the last 10 years reveals a growth in integrative approaches incorporating behavioral, neuropsychological, and social information. In addition, the concurrent recognition of limitations associated with simple cross-sectional age-group comparisons along with the use of more complex methods has resulted in the development of increasingly sophisticated research designs and analytic tools focused on understanding a multitude of potential mediators and moderators of cognitive change. This all has led away from a monolithic—often negative—view of cognitive aging to one that is more nuanced and sensitive to contextual factors. This recent shift in the psychology of aging discipline from describing cognitive aging in terms of limitations into one focused on understanding the factors associated with adaptive functioning in later life is a prime inspiration for the present volume. Thus, an emphasis here is on understanding both the factors underlying individual differences in trajectories of change in cognitive functioning in later life and the nature of compensatory mechanisms developed by most successful and active middle-aged and older adults through their experiences in dealing with complex tasks. This includes the consideration of motivational factors as a driver of both cognitive change and adaptive functioning. The 15 contributions offer unique insights and highlight innovative methodological approaches that have been used to study these issues.

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24

Catapan, Edilson Antonio, ed. Education oriented principles and fundamentals. South Florida Publishing, 2021. http://dx.doi.org/10.47172/sfp2020.ed.0000012.

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The book “Education oriented principles and fundamentals 1 ST Edition, edited and published by South Florida Publishing, gathers five chapters that approach themes of relevance in the context of education and are available in Spanish. In the first chapter, a research is presented, whose objective is to provide the basis for a pro-student persistence model in higher education applicable in unfavorable socio-academic contexts. The second chapter presents a teaching model that is presented to design teaching as a basis for the use of cognitive strategies, and it is also necessary to establish different strategies to be able to pedagogically evaluate the performance of the student. The third chapter presents a search for a model for the assessment of competencies in basic education through a case study at the Los Pinos de Algeciras school. We are in the middle of the infant school. The fourth chapter, the importance of creating and dynamizing the narrative is supported by the promotion of emerging reading behaviors in day care centers. It is also intended to contribute to the reflection on the role of the educator / mediator in promoting an educational project that facilitates intervention in day care centers. The emerging literacy level. And finally, or the fifth chapter, as a novel educational experience, the application of the Flipped Classroom Model to the teaching of classical culture was drawn, highlighting the importance of the elaboration of interesting and motivating multimedia didactic materials for the students, supported by the use of the new technologies, to improve teaching practice by organizing work in the classroom in an active and participatory way. Thus, we thank all authors for their commitment and dedication to their work and we hope to be able to contribute to the scientific community, in the dissemination of knowledge and in the advancement of science.

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