Dissertations / Theses on the topic 'Mechanistic model'
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Yeung, Luk Chong. "A mechanistic model of calcium-dependent synaptic plasticity /." View online version; access limited to Brown University users, 2005. http://wwwlib.umi.com/dissertations/fullcit/3174704.
Full textDrost, Roelof Gerrit. "MAIS, a mechanistic model of maize growth and development." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ61892.pdf.
Full textLenting, Christoph [Verfasser]. "Glass corrosion : Towards a Unifying Mechanistic Model / Christoph Lenting." Bonn : Universitäts- und Landesbibliothek Bonn, 2019. http://d-nb.info/1201727863/34.
Full textBaird, Mark E. "Towards a verified mechanistic model of plankton population dynamics." Thesis, University of Warwick, 1999. http://wrap.warwick.ac.uk/1123/.
Full textNobari, Amir Hossein. "Mechanistic jet impingement model for cooling of hot steel plates." Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/47099.
Full textApplied Science, Faculty of
Materials Engineering, Department of
Graduate
Deen, William. "A mechanistic model of common ragweed based on photothermal time." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0019/NQ47389.pdf.
Full textMa, John W. "Mechanistic model studies of living nitroxide-mediated styrene miniemulsion polymerization." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2002. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/NQ65680.pdf.
Full textHamzat, Kadri Obafemi. "A semi-mechanistic model based on oil expression from groundnuts." Thesis, Cranfield University, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333986.
Full textMa, Yuxin. "Empirical and Mechanistic Modelling for Process Understanding in Digital Soil Mapping." Thesis, The University of Sydney, 2019. https://hdl.handle.net/2123/21413.
Full textVan, Tonder Jacob John. "Development of an in vitro mechanistic toxicity screening model using cultured hepatocytes." Thesis, University of Pretoria, 2011. http://hdl.handle.net/2263/24162.
Full textThesis (PhD)--University of Pretoria, 2011.
Pharmacology
unrestricted
Zorzetto, Luiz Flavio Martins. "Bioprocess monitoring with hybrid neural network/mechanistic model based state estimators." Thesis, University of Nottingham, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283350.
Full textAb, Hadi H. "Mechanistic studies of the permeation behaviour of a model hydrophilic compound." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1381750/.
Full textWagih, Omar. "Elucidating the mechanistic impact of single nucleotide variants in model organisms." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/271713.
Full textMense, Jelte Pierc. "New general mechanistic model for predicting civil disturbances and their characteristics." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28763.
Full textAlsirawan, M. B., X. Lai, R. Prohens, Venu R. Vangala, S. K. Pagire, S. Petroc, T. J. Bannan, D. O. Topping, and Anant R. Paradkar. "Solid-State Competitive Destabilization of Caffeine Malonic Acid cocrystal: Mechanistic and Kinetic Investigation." American Chemical Society, 2020. http://hdl.handle.net/10454/18305.
Full textThe main objective of this research is to investigate solid-state destabilization mechanism and kinetics of the model cocrystal caffeine : malonic acid (CA:MO) in presence of oxalic acid (OX) as a structural competitor. Competitive destabilization of CA:MO and subsequent formation of CA:OX takes place at temperatures significantly below its melting point. Destabilization mechanism was found to be mediated by sublimation of both CA:MO and OX. During CA:MO destabilization, free CA could not be detected and direct transformation to CA:OX cocrystal was observed. The destabilization kinetics follow Prout-Tompkins nucleation and crystal growth model with activation energy of 133.91 kJ/mol and subsequent CA:OX growth kinetic follow Ginstling – Brounshtien diffusion model with activation energy of kJ/mol.
The full-text of this article will be released for public view at the end of the publisher embargo on 28 Oct 2021.
Al-johani, Mohammed S. "A three-dimensional mechanistic model of steam condensers using porous medium formulation." Diss., Georgia Institute of Technology, 1996. http://hdl.handle.net/1853/19448.
Full textPaiement, Jean-Pierre. "Evaluation of a model system for the mechanistic study of gene targeting." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84103.
Full textSostelly, Alexandre. "Mechanistic model-based drug development in the management of anticancer drugs resistance." Thesis, Lyon 1, 2012. http://www.theses.fr/2012LYO10203.
Full textAnticancer drug resistance is a major issue in the management of cancer disease. Efflux transporters contribute to the multidrug resistance by altering the intracellular disposition of cytotoxic drugs. In the past, the inhibition of P-gp efflux transporter essentially failed because of the lack of adequate methods to identify their mechanisms of action. Recently, new inhibitors of BCRP, one of the latest efflux transporter that have been discovered, have been developed that allow re-testing the multidrug resistance inhibition through efflux inhibition. Nevertheless, to avoid the same issues of development as for P-gp inhibitors, new methods have to be used. This PhD work aims to demonstrate the benefits of mechanistic models to support the development of efflux transporter inhibitors and more generally of oncology compounds through two axes: - The development of mechanistic models of the interaction between cytotoxic and efflux transporter inhibitors - The development of quantitative tumour growth inhibition models to early evaluate oncology compounds and optimize patients’ response The results obtained with this approach allow the identification of key mechanisms of efflux transporter inhibitors and demonstrate the power of modelling and simulation to support oncology drug development
Nowacki, Brenna M. "Verification and Calibration of State-of-the-Art CMC Mechanistic Damage Model." University of Dayton / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=dayton1461761780.
Full textPoon, Jonathan Ming-Hin. "A three-dimensional population balance model of granulation processes employing mechanistic kernels." Thesis, Imperial College London, 2008. http://hdl.handle.net/10044/1/8041.
Full textLong, Yu. "Mechanistic insights into acid-catalysed pyrolysis of cellulose and its model compounds." Thesis, Curtin University, 2022. http://hdl.handle.net/20.500.11937/89062.
Full textKim, Yong Sik. "Kinetic and mechanistic studies of polyoxometalate (POM) reaction with lignin and model compounds." Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/31366.
Full textForestry, Faculty of
Graduate
Skår, Helene. "Simulation of Surfactant EOR in a Mechanistic Model with Fracture and Ekofisk Properties." Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for petroleumsteknologi og anvendt geofysikk, 2014. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-25910.
Full textTabor, Joseph Edward. "A fogging scrubber to treat diesel exhaust: field testing and a mechanistic model." Thesis, Virginia Tech, 2020. http://hdl.handle.net/10919/99443.
Full textMaster of Science
Diesel particulate matter (DPM) describes the solid portion of diesel exhaust. These particles are in the nanometer size range (10-1000nm) and can penetrate deep within the lungs presenting a serious health hazard. Because of the use of diesel powered equipment in confined spaces, DPM presents an occupational hazard for underground mine workers. Even with the use of cleaner fuels, regular engine maintenance, proper ventilation, and enclosed vehicle cabs, workers can still be over exposed. Previous work has shown that a water fog treatment can help to remove DPM from the air in a laboratory setting. This removal is due to the DPM particles attaching to the drops, followed by the drops settling out of the air due to gravity or impacting the walls of a tube. To explore a full scale exhaust treatment, a fogging scrubber was built using a fogger and a long tube, and was tested in an underground mine on vehicle exhaust. Experimental results showed that the fog treatment was effective at removing DPM from the exhaust. On average, the fog improved DPM removal by about 55% compared to when the treatment was not employed (fog off). To better understand the mechanisms responsible for DPM removal in the scrubber, a computer model was generated. The model uses the inlet parameters from the field tests, such as inlet DPM and fog concentration and tube geometry, and predicts the scrubber outlet DPM concentration. The model results suggest that the primary way that DPM is removed from the system is by combining with fog drops, which then hit the scrubber tube walls. This effect is probably enhanced by the ribbed structure of the scrubber tubing used here, which may be important for practical applications.
Li, Hui. "A Mechanistic Model for CO2 Localized Corrosion of Carbon Steel." Ohio University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1304558358.
Full textCamino, Eric M. "A Mechanistic Analysis of Gene Regulation and its Evolution in a Drosophila Model." University of Dayton / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=dayton1461242188.
Full textArenas, Amado Antonio. "Development and application of a mechanistic model to predict juvenile salmon swim paths." Diss., University of Iowa, 2012. https://ir.uiowa.edu/etd/2813.
Full textRantow, Felix Suryaman Soroush Masoud Grady Charles. "Mechanistic modeling and model-based studies in spontaneous solution polymerization of alkyl acrylate monomers /." Philadelphia, Pa. : Drexel University, 2006. http://hdl.handle.net/1860/1306.
Full textRoy, Shouvik. "Mechanistic studies of physico-chemical stability of model therapeutic proteins using pharmaceutically relevant factors /." Connect to full text via ProQuest. IP filtered, 2006.
Find full textTypescript. Includes bibliographical references (leaves 161-173). Free to UCDHSC affiliates. Online version available via ProQuest Digital Dissertations;
Groenewegen, Hendrik Cornelis. "Therapeutic and mechanistic explorations of in-stent restenosis in the rat aortic stenting model." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 2008. http://irs.ub.rug.nl/ppn/.
Full textSmith, Robert A. W. "The role of monoethanolamine in hair bleaching and dyeing : mechanistic insights from model formulations." Thesis, University of York, 2014. http://etheses.whiterose.ac.uk/8316/.
Full textKim, Jaeyeon. "Model Analysis of Adipose Tissue and Whole Body Metabolism In Vivo." Case Western Reserve University School of Graduate Studies / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1216436630.
Full textSiriwardena, Dylan. "Determination of Immunomodulatory Bioactivity Biomarkers and Mechanistic Insights in Umbilical Cord Mesenchymal Stromal Cells." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/38497.
Full textCzamanski-Cohen, J., and K. L. Weihs. "The Bodymind Model: A platform for studying the mechanisms of change induced by art therapy." Elsevier, 2016. http://hdl.handle.net/10150/621993.
Full textDominguez, Olivo Juan M. "Electrochemical Model of Carbon Dioxide Corrosion in the Presence of Organic Corrosion Inhibitors." Ohio University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1577092234789695.
Full textGuo, Juen. "A study of glucose metabolism and ketosis development in periparturient cows using a mechanistic model." College Park, Md. : University of Maryland, 2005. http://hdl.handle.net/1903/2383.
Full textThesis research directed by: Animal Sciences. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.
Luo, Zairen. "Flexible Pavement Condition Model Using Clusterwise Regression and Mechanistic-Empirical Procedure for Fatigue Cracking Modeling." See Full Text at OhioLINK ETD Center (Requires Adobe Acrobat Reader for viewing), 2005. http://www.ohiolink.edu/etd/view.cgi?toledo1133560069.
Full textTypescript. "A dissertation [submitted] as partial fulfillment of the requirements of the Doctor of Philosophy degree in Engineering." Bibliography: leaves 90-99.
Bargh, Mary Katharine. "A mechanistic model to predict nutritional effects on milk fatty acid profile in dairy cows." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ56303.pdf.
Full textSingh, Sunil. "Engineered Organotypic Breast Tumor Model for Mechanistic Studies of Tumor-Stromal Interactions and Drug Discovery." University of Akron / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=akron1616940345310981.
Full textRead, Jonathan M. "The effect of plant traits and resource supply characteristics on plant competition : a mechanistic model." Thesis, University of Stirling, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244695.
Full textMcCormack, John Patrick. "A three-dimensional mechanistic ozone transport model: Applications to midlatitude trends and 11-year variability." Diss., The University of Arizona, 1996. http://hdl.handle.net/10150/290698.
Full textBritton, Peter C., Jessica M. McKinney, Todd M. Bishop, Wilfred R. Pigeon, and Jameson K. Hirsch. "Insomnia and Risk for Suicidal Behavior: A Test of a Mechanistic Transdiagnostic Model in Veterans." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/etsu-works/5545.
Full textLin, Yangchen. "Macroscopic insights from mechanistic ecological network models in a data void." Thesis, University of Cambridge, 2015. https://www.repository.cam.ac.uk/handle/1810/254976.
Full textRezsöhazy, Jeanne. "Data-model fusion approach using tree-ring width series, a mechanistic growth model and an Earth system model to reconstruct the large-scale climate variability." Thesis, Aix-Marseille, 2021. http://www.theses.fr/2021AIXM0618.
Full textTree-ring width represent the most commonly used proxy to reconstruct the climate of the last millennium at high resolution, thanks to their large-scale availability. The approach often relies on a relationship between tree-ring width series and climate estimated on the basis of a linear regression. The underlying linearity and stationarity assumptions may be inadequate. Dendroclimatic process-based models may be able to overcome some of the limitations of the statistical approach. In this thesis, we propose to include for the first time a dendroclimatic process-based model, MAIDEN, into a data assimilation procedure in order to potentially improve large-scale climate reconstructions. We have first developed a protocol to calibrate and apply MAIDEN to potentially any sites with tree-ring width data in the extratropical region. We have shown that MAIDEN can be applied at global scale with a good performance and that clear benefits associated with its level of complexity make it an appealing candidate for paleoclimate reconstructions. Subsequently, the MAIDEN model has been successfully incorporated into a data assimilation procedure as a proxy system model to robustly compare climate model outputs with tree-ring width observations. The procedure has been tested to reconstruct the climate variability in the Southern Hemisphere over the last four centuries. Even if the results are encouraging, additional analysis are needed in order to establish that it may significantly improve large-scale climate reconstructions compared to a regression model in the data assimilation framework
Larsson, Dhana E. "Analyses of Dose-Response and Mechanistic Action of Different Anti-Cancer Drugs for Neuroendocrine Tumor Cell Lines." Doctoral thesis, Uppsala universitet, Institutionen för medicinska vetenskaper, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-158833.
Full textTitle corrected from: Analyses of Dos-Response and Mechanistic Action of Different Anti-Cancer Drugs for Neuroendocrine Tumor Cell Lines
Sjödin, Martin. "Regulation of Proton Coupled Electron Transfer from Amino Acids in Artificial Model Systems: A Mechanistic Study." Doctoral thesis, Uppsala University, Department of Physical Chemistry, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4132.
Full textAmino acid radicals are key redox intermediates in several natural enzymes including Cytochrome c peroxidase, DNA photolyase, ribonucletide reductase, cytochrome c oxidase and photosystem II. Electron transfer from amino acids is often coupled to deprotonation and this thesis concerns the coupling of electron transfer from tyrosine and tryptophan to trisbipyridineruthenium(III) with deprotonation in model complexes. Specifically the mechanisms for these proton coupled electron transfer reactions have been studied and the controlling parameters have been identified, the possible mechanisms being stepwise electron transfer followed by deprotonation and deprotonation followed by electron transfer or concerted electron transfer/deprotonation.
Proton coupled electron transfer reactions have been studied using nano-second flash photolysis in water solution and the effect of pH, temperature, reaction driving force, deuteration and nature of the amino acid has been determined. I have shown that the rate constant for the concerted reaction depends intrinsically on the mixing entropy of the released proton and that the pH-dependence can be used as an experimental tool for mechanistic discrimination. Moreover I have shown that the concerted reaction inherently has a high reorganisation energy due to the coupling of the electron motion with deprotonation. Hydrogen bonding to the transferring proton however significantly reduces this reorganisation energy. The concerted reaction also has a relatively high driving force counteracting the high reorganisation energy in the competition between the concerted reaction and the stepwise electron transfer first reaction. The relative importance of the high reorganisation energy and the high driving force for the concerted reaction determines the mechanistic outcome of the reaction, the stepwise reaction being favoured by high over-all driving forces and the concerted reaction by high pH.
By comparing my results from model complexes with tyrosineZ oxidation in photosystem II, I give strong evidence for a concerted electron transfer/deprotonation mechanism.
Sjödin, Martin. "Regulation of proton coupled electron transfer from amino acids in artificial model systems : a mechanistic study /." Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4132.
Full textAngenendt, Alexandra. "Ecophysiological studies of field beans : a simple yet mechanistic crop growth model for Vicia faba L." Thesis, University of Reading, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250720.
Full textGaber, Noha. "Development of a mechanistic model to assess the distribution of heavy metals in municipal wastewater treatment." Thesis, University of Southampton, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342771.
Full textHicks, Mark. "Reactivity and mechanistic studies of small molecules at model metal oxide surfaces : underpinning PuO2 safe storage." Thesis, Cardiff University, 2015. http://orca.cf.ac.uk/69894/.
Full text