Dissertations / Theses on the topic 'Mechanical'

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1

Marcucci, Lorenzo. "A mechanical model of muscle mechanics." Phd thesis, Ecole Polytechnique X, 2009. http://pastel.archives-ouvertes.fr/pastel-00004880.

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2

Matek, Christian C. A. "Statistical mechanics of nucleic acids under mechanical stress." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:ce44cf50-2001-4f54-8e57-d1757f709fd6.

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In this thesis, the response of DNA and RNA to linear and torsional mechanical stress is studied using coarse-grained models. Inspired by single-molecule assays developed over the last two decades, the end-to-end extension, buckling and torque response behaviour of the stressed molecules is probed under conditions similar to experimentally used setups. Direct comparison with experimental data yields excellent agreement for many conditions. Results from coarse-grained simulations are also compared to the predictions of continuum models of linear polymer elasticity. A state diagram for supercoiled DNA as a function of twist and tension is determined. A novel confomational state of mechanically stressed DNA is proposed, consisting of a plectonemic structure with a denaturation bubble localized in its end-loop. The interconversion between this novel state and other, known structural motifs of supercoiled DNA is studied in detail. In particular, the influence of sequence properties on the novel state is investigated. Several possible implications for supercoiled DNA structures in vivo are discussed. Furthermore, the dynamical consequences of coupled denaturation and writhing are studied, and used to explain observations from recent single molecule experiments of DNA strand dynamics. Finally, the denaturation behaviour, topology and dynamics of short DNA minicircles is studies using coarse-grained simulations. Long-range interactions in the denaturation behaviour of the system are observed. These are induced by the topology of the system, and are consistent with results from recent molecular imaging studies. The results from coarse-grained simulations are related to modelling of the same system in all-atom simulations and a local denaturation model of DNA, yielding insight into the applicability of these different modelling approaches to study different processes in nucleic acids.
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3

Porro, Cristina Shino. "Quantum mechanical/molecular mechanics studies of Cytochrome P450BM3." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/quantum-mechanical--molecular-mechanics-studies-of-cytochrome-p450bm3(ad4255e7-b779-47a2-a2c5-8dbf6b603ca5).html.

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Cytochrome P450 (P450) enzymes are found in all kingdoms of life, catalysing a wide range of biosynthetic and metabolic processes. They are, in fact, of particular interest in a variety of applications such as the design of agents for the inhibition of a particular P450 to combat pathogens or the engineering of enzymes to produce a particular activity. Bacterial P450BM3 is of particular interest as it is a self-sufficient multi-domain protein with high reaction rates and a primary structure and function similar to mammalian isoforms. It is an attractive enzyme to study due to its potential for engineering catalysts with fast reaction rates which selectively produce molecules of high value.In order to study this enzyme in detail and characterise intermediate species and reactions, the first step was to design a general hybrid quantum mechanical /molecular mechanics (QM/MM) computational method for their investigation. Two QM/MM approaches were developed and tested against existing experimental and theoretical data and were then applied to subsequent investigations.The dissociation of water from the water-bound resting state was scrutinised to determine the nature of the spin conversion that occurs during this transformation. A displacement of merely 0.5 Å from the starting state was found to trigger spin crossing, with no requirement for the presence of a substrate or large conformational changes in the enzyme.A detailed investigation of the sulfoxidation reaction was undertaken to establish the nature of the oxidant species. Both reactions involving Compound 0 (Cpd0) and Compound I (CpdI) confirmed a concerted pathway proceeding via a single-state reactivity mechanism. As the reaction involving Cpd0 was found to be unrealistically high, the reaction proceeds preferentially via the quartet state of CpdI. This QM/MM study revealed that the preferred spin-state and the transition state structure for sulfoxidation are influenced by the protein environment. P450cam and P450BM3 were found to have CpdI species with different Fe-S distances and spin density distributions, and the latter having a larger reaction barrier for sulfoxidation.A novel P450 species, the doubly-reduced pentacoordinated system, was characterised using gas-phase and QM/MM methods. It was discovered to have a heme radical coupled to two unpaired electrons on the iron centre, making it the only P450 species to have similar characteristics to CpdI. Calculated spectroscopic parameters may assist experimentalists in the identification of the elusive CpdI.
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4

Guillou, Lionel. "Cell Mechanics : Mechanical Properties and Membrane Rupture Criteria." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLX041/document.

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L’athérosclérose est une maladie artérielle chronique qui est une des causes majeures d’accidents vasculaires cérébraux et de crises cardiaques. Cette thèse a pour objectif de mieux comprendre certains facteurs spécifiques impliqués dans le dévelopement de cette maladie en abordant cette problématique sous l’angle de la mécanique.Deux types de cellules qui jouent un rôle important dans le dévelopement et la progression de l’athérosclérose sont les cellules endothéliales adhérentes et les leucocytes non-adhérents (les globules blancs). Nous avons développé deux systèmes capables de mesurer les propriétés mécaniques de ces deux grands types cellulaires. Le premier, appelé “indentation de profil”, utilise des micropipettes et des microindenteurs pour indenter la cellule, tandis que le second utilise la microfluidique pour soumettre les cellules à une contrainte d’élongation.De plus, nous nous sommes demandé si la mécanique pouvait nous aider à comprendre quand les déformations des cellules, ou les contraintes exercées sur elles, pouvaient les endommager.En effet, lorsque les plaques d’athérosclérose obstruent une partie trop grande du flux sanguin, le traitement le plus courant consiste à rouvrir le vaisseau avec un ballon et à le maintenir ouvert au moyen d’une endoprothèse artérielle, qui est un petit dispositif maillé et tubulaire. Cette procédure exerce des contraintes de compression considérables sur l’endothélium et l’endommage. Nous avons donc cherché à trouver un critère physique prédictif de la rupture de la membrane des cellules endothéliales en compression, puis avons comparé cela aux contraintes exercées sur l’endothélium durant la pose d’une endoprothèse artérielle, afin de voir si les dommages faits à l’endothélium pouvaient potentiellement être évités.De façon similaire, nous avons cherché à obtenir un critère physique prédictif de la rupture de la membrane des leucocytes. Nous avons ensuite comparé les déformations maximales possibles des leucocytes selon que ces déformations soient passives (comme lors du passage dans la microvasculature) ou actives (comme lors de la traversée de l’endothélium par les leucocytes)
Atherosclerosis is a chronic disease of the arteries that is a major cause of heart attacks and strokes. This thesis aims to provide novel insight into this disease by looking at specific factors involved in its development from a mechanical standpoint.Two important cell types involved in the development and progression of atherosclerosis are adherent endothelial cells and non-adherent leukocytes (white blood cells). We developed two devices that are able to measure the mechanical properties of both of these cell types. The first one, termed “profile microindentation”, uses micropipettes and microindenters to indent the cell, while the second one uses microfluidics to submit cells to an extensional stress.Further, we wondered if mechanics could help us understand when deformations undergone by cells, or stresses exerted on them, could become harmful.As a matter of fact, when atherosclerotic plaques occlude too much of the blood flow, the most common treatment consists of reopening the vessel with a balloon and keeping it open with a tubular wired mesh called a stent. This procedure exerts considerable compressive stress on the endothelium and is known to be associated with extensive endothelial damage. Hence, we seek to find a physical criterion that is predictive of endothelial cell membrane rupture under compression and to compare this to the stress exerted on the endothelium during the stenting procedure, to see if endothelial damage could potentially be avoided.Similarly, we seek to obtain a physical criterion that is predictive of leukocyte membrane rupture. We then compare and contrast the maximum possible deformations of leukocytes depending on whether those deformations are passive (such as when going through the microvasculature) or active (such as when leukocytes traverse the endothelial barrier)
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5

Miao, Yuyang. "Mechanics of textile composites : from geometry to mechanical properties /." Search for this dissertation online, 2005. http://wwwlib.umi.com/cr/ksu/main.

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6

Blackstone, Britani Nicole. "Biomaterial, Mechanical and Molecular Strategies to Control Skin Mechanics." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1406123409.

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7

Lai, Jiun-Yu. "Mechanics, mechanisms, and modeling of the chemical mechanical polishing process." Thesis, Massachusetts Institute of Technology, 2001. http://hdl.handle.net/1721.1/8860.

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Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2001.
Includes bibliographical references.
The ever-increasing demand for high-performance microelectronic devices has motivated the semiconductor industry to design and manufacture Ultra-Large-Scale Integrated (ULSI) circuits with smaller feature size, higher resolution, denser packing, and multi-layer interconnects. The ULSI technology places stringent demands on global planarity of the Interlevel Dielectric (ILD) layers. Compared with other planarization techniques, the Chemical Mechanical Polishing (CMP) process produces excellent local and global planarization at low cost. It is thus widely adopted for planarizing inter-level dielectric (silicon dioxide) layers. Moreover, CMP is a critical process for fabricating the Cu damascene patterns, low-k dielectrics, and shallow isolated trenches. The wide range of materials to be polished concurrently or sequentially, however, increases the complexity of CMP and necessitates an understanding of the process fundamentals for optimal process design. This thesis establishes a theoretical framework to relate the process parameters to the different wafer/pad contact modes to study the behavior of wafer-scale polishing. Several models of polishing - microcutting, brittle fracture, surface melting and burnishing - are reviewed. Blanket wafers coated with a wide range of materials are polished to verify the models. Plastic deformation is identified as the dominant mechanism of material removal in fine abrasive polishing.
(cont.) Additionally, contact mechanics models, which relate the pressure distribution to the pattern geometry and pad elastic properties, explain the die-scale variation of material removal rate (MRR) on pattern geometry. The pad displacement into low features of submicron lines is less than 0.1 nm. Hence the applied load is only carried by the high features, and the pressure on high features increases with the area fraction of interconnects. Experiments study the effects of pattern geometry on the rates of pattern planarization, oxide overpolishing and Cu dishing. It was observed that Cu dishing of submicron features is less than 20 nm and contributes less to surface non-uniformity than does oxide overpolishing. Finally, a novel in situ detection technique, based on the change of the reflectance of the patterned surface at different polishing stages, is developed to detect the process endpoint and minimize overpolishing. Models that employ light scattering theory and statistical treatment correlate the sampled reflectance with the surface topography and Cu area fraction for detecting the process regime and endpoint. The experimental results agree well with the endpoint detection schemes predicted by the models.
by Jiun-Yu Lai.
Ph.D.
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8

Liu, Guoning. "Application of fracture mechanics in electrical/mechanical failures of dielectrics /." View abstract or full-text, 2006. http://library.ust.hk/cgi/db/thesis.pl?MECH%202006%20LIU.

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9

Jonsson, Anders. "Integral equation methods for fracture mechanics and micro-mechanical problems." Doctoral thesis, KTH, Solid Mechanics, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3336.

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10

Levert, Joseph Albert. "Interface mechanics of chemical mechanical polishing for integrated circuit planarization." Diss., Georgia Institute of Technology, 1997. http://hdl.handle.net/1853/15914.

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11

Svantesson, Cecilia. "Respiratory mechanics during mechanical ventilation in health and in disease." Lund : Dept. of Clinical Psychology, Lund University, 1997. http://catalog.hathitrust.org/api/volumes/oclc/38987113.html.

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12

Kleinauskas, Marius. "Dviračio vairo statinio stiprumo ir standumo tyrimai." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2006. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2006~D_20060614_011209-33463.

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Kleinauskas M. Research of static strenght and rigidity for wheel of bicycle: Master there is of mechanical engineer/ research advisor S.Rimovskis; Šiauliai University, Technology Faculty, Mechanical Engineering Department. – 2006. – 37p. In the countries of world bicycle is not only a widely used commodity, means of transport, but an index of mode of life. This work analyses a very important part of bicycle construction – a wheel. Strength and rigidity analysis are made using analytical and numerical solving methods. The main purposes of solving are elastic stress distribution in the wheel and the maximum value of the residual deflection. The condition and magnitude of load were estimated according to standard DIN 97100. Received results show if the wheel exploitation reliability is good ant its parameters meet the requirements of standards. The aim of the research: to prepare the methods of bicycle wheel strength and rigidity analysis for researches. Using the programme package ANSYS, to make wheel construction FEM model and perform strength and rigidity numerical solving, estimating of elastic plastic loading conditions.
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13

Klasmer, Gabriel. "Assassin : mechanical painting in the post mechanical age." Thesis, Royal College of Art, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.534689.

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14

Katiyar, Pushkar. "PROCESSING, MICROSTRUCTURAL AND MECHANICAL CHARACTERIZATION OF MECHANICALLY ALLOYED Al-Al2O3 NANOCOMPOSITES." Master's thesis, University of Central Florida, 2004. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/4496.

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Aluminum-alumina nanocomposites were synthesized using mechanical alloying of blended component powders of pure constituents. This study was performed on various powder mixtures with aluminum as the matrix and alumina as the reinforcement with volume fractions of 20, 30, and 50 % and Al[subscript 2]O[subscript 3] particle sizes of 50 nm, 150 nm, and 5 [mu]m. X-ray diffraction (XRD) and scanning electron microscopy (SEM) techniques were used for the crystal structure and microstructural characterization of the powders at different stages of milling. Al?O? powders with 50 nm and 150 nm particle size were predominantly of [gamma]-type, while Al[subscript 2]O[subscript 3] of 5 [mu]m size was of [alpha]-type. The main goal was to achieve uniform distribution of the Al?O? ceramic particles in the Al matrix, which was achieved on milling for 24 h in a SPEX mill or 100 h in a Fritsch Pulverisette planetary ball mill. The powders were consolidated in two stages: pre-compaction at room temperature followed by vacuum hot pressing (VHP) or hot isostatic pressing (HIP) techniques to a fully dense condition. The effect of reinforcement particle size and volume fraction on the stress-strain response, elastic modulus and yield strength of the composites was investigated. Nanoindentation and compression tests were performed to characterize the composite material. Yield strength of 515 MPa, compressive strength of 685 MPa and elastic modulus of 36 GPa were obtained from compression tests. Nanoindentation results gave the yield strength of 336 MPa, maximum shear stress of 194 MPa and an elastic modulus of 42 GPa. The low elastic modulus values obtained from the above tests might be because of localized yielding possibly due to residual stresses.
M.S.
Department of Mechanical, Materials and Aerospace Engineering;
Engineering and Computer Science
Materials Science and Engineering
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15

Wolff, Lars, and Klaus Kroy. "Mechanical stability." Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-190323.

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The glassy wormlike chain model is a highly successful phenomenological model recently introduced to describe anomalously slow subdiffusive dynamics in biopolymer networks and living cells. Here we extend this model by proposing a generic scheme how to include nonlinear plastic effects by introducing the possibility of force-dependent opening and closing of internal bonds. Further, we discuss physiological implications of this bond kinetics. Stability arguments lead us to the postulation of a “physiological sheet” in the parameter space. This sheet defines the set of parameters characterizing cells which are flexible enough to perform biological tasks while still being able to bear external perturbations characteristic of their surroundings and their internally generated prestress without damage. At the end of this contribution, we speculate about the connection between prestress and cell stiffness and about the mechanism by which the cell adapts to its mechanical environment.
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16

Dahlin, Sanna, and Henrik Fagerlund. "Mechanical Mirror." Thesis, KTH, Mekatronik, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-296234.

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This bachelor thesis aims to present an overview of the performed steps to construct and program a prototype of a mechanical mirror. The idea of a mechanical mirror is that a camera captures an image that is translated into pixels of different brightness values. The brightness values are later displayed by metal plates, acting as pixels, rotated to different angles to reflect a corresponding light from a lamp. The pixels together shape grayscale images based on the frames captured by the camera. A prototype was constructed successfully. Tests showed that its purpose to move according to the captured image was fulfilled although adjustments could be made for the light to reach all the pixels to a greater extent. The angle span for the pixels turned out to be between 32°and 44°, which proved sufficient for their purpose. The reason for a difference in angle spans between the pixels was due to minor construction errors and was not an issue of functionality for the mirror. The refresh rate of the mirror, which could be described as the frequency at which the pixels rotate and shape an image, was set to 25 frames per second. This allowed the mirror to mimic movements in front of it without much delay while not exceeding the frame rate of the camera, which capture at a frame rate of 30 frames per second. The camera was therefore the vital limitation for the refresh rate of the mirror.
Detta kanidatexamensarbete har syftet att presentera en översikt av de steg som genomfördes för att konstruera och programmera en prototyp av en mekanisk spegel. Idén med en mekanisk spegel är att en kamera läser in en bild som sedan är översatt till pixlar med olika värden på ljusstyrka. Dessa ljusstyrkor visas sedan av metallplattor, vilka agerar som pixlar, som roterar till olika vinklar för att reflektera motsvarande ljus från en lampa. Pixlarna formar tillsammans gråskalebilder baserat på de bilder som kameran läser in. En prototyp konstruerades framgångsrikt. Test visade att dess syfte att röra sig i enlighet med den inlästa bilden uppfylldes, dock finns plats för justeringar för att ljuset från lampan ska nå pixlarna i större utsträckning. Pixlarnas vinkelomfång visade sig bli mellan 32°och 44°, vilket konstaterades vara tillräckligt för deras syfte. Skillnaden i vinkelomfång mellan pixlarna berodde på mindre konstruktionsfel och påverkade inte spegelns funktionalitet. Spegelns uppdateringsfrekvens, vilket kan beskrivas som frekvensen med vilken pixlarna roterar och formar en bild, sattes till 25 bilder per sekund. Detta tillät spegeln att härma rörelser framför den utan stor fördröjning utan att överstiga kamerans bildhastighet, som läser in med en bildhastighet på 30 bilder per sekund. Kameran var således den begränsade faktorn för pixlarnas uppdateringsfrekvens.
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17

Sheeter, Eric. "Mechanical silviculture." Thesis, Loughborough University, 1991. https://dspace.lboro.ac.uk/2134/10527.

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Problem: How to mechanise tree planting in North American logged sites? Trees are presently hand planted. Preliminary exploration identified the following collection of sub-problems. Vehicle: How to carry tools reliably and cost effectively over rough obstacle strewn ground? Results: U.S.A. - patent granted European Patent Office - patent granted Canada - patent granted The patents cover the main form and mode of operation of a simple but unconventional vehicle. Silvicultural/mechanical: How to mechanise the handling and placement of trees? Results: Two International Patents allowed. They cover a magazine/feed mechanism and a placement mechanism. They form a planting tool. One man guides the vehicle/tool system. An array of planting tools is carried. Two problems arise from the need to make guidance manageable and the planting rate fast enough. Spacing: How to cause the members of a collection of simultaneously operating tools to space themselves appropriately the spacing being driven by machine perceived cues? Choice: How to cause a tool to move to and halt over a plan table spot, tool action being driven by machine perceived cues? Results: One International Patent allowed. Spacing: A conceptual solution is described. Choice: A semi-automatic solution is described. It involves a system of tool guidance and a system of tool set-up, both light guided. Two methods for the detection of light signals in the presence of sunlight have been investigated. Choice-automatic; two solutions have been explored. One uses standard data processing, the other "parallel" processing. Here an idealised device is described which will compare for likeness two two-dimensional patterns.
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18

Yue, Peng. "A micro mechanical study of critical state soil mechanics using DEM." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/38060/.

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One of the greatest breakthroughs in soil mechanics was the development of Critical State Soil Mechanics (CSSM) in the 1950s and 1960s and the derivation of a continuum elasto-plastic constitutive model, namely Cam clay, which was the foundation for other continuum models for clays, and much later for sands. However, as yet there has been no micro mechanical analysis which explains the existence of such continuum models; such a micro perspective must take into account the discontinuous nature of soil. Without such insight, the engineer cannot understand which micro parameters affect soil behaviour. This work uses the discrete element method (DEM) to model a silica sand as a sample of discrete particles, with properties which have been calibrated against experimental data in previous work, to build up a micro mechanical picture of the behaviour of sand under different loading conditions. The simplest of loading conditions is the one dimensional or oedometer test and has been modelled to check whether this agrees with previously published research. The simulated sample has then been subjected to isotropic compression to establish a normal compression line in log voids ratio – log stress space, and which turns out to be parallel to the one-dimensional normal compression line, in agreement with CSSM. The evolution of the isotropic normal compression line is due to local shear stresses within the sample, and the origin of the existence of both lines lies in the evolution of a fractal distribution of particles with a fractal dimension of 2.5. The effect of boundary particles has then been minimised by choosing an appropriate aspect ratio and a smaller number of particles in the sample to give a computational time which is acceptable for subsequent shearing to critical states. Isotropically normally compressed samples have been unloaded to different stress levels and sheared to critical states. A unique critical state line (CSL) exists at high stress levels, which is parallel to the normal compression lines, in agreement with CSSM. At low stress levels, the CSL is not linear and is non-unique; that is to say it is a function of preconsolidation pressure because the fractal distribution of sizes has not fully evolved. Samples sheared on the dense side of critical dilate and have a peak strength whilst loose samples exhibit ductile contraction, in agreement with CSSM. At a critical state, the work shows that crushing continues in the formation of ‘fines’, small particles with smaller than 0.1mm dimensions, which plays no part in the mechanical behaviour, which is reflected in the average mechanical co-ordination number and which means that plastic hardening can be assumed to have ceased at a critical state. For the isotropically overconsolidated samples sheared to critical states, a number of different definitions of yield have been used to establish a yield surface in stress space. The work shows that a previously published yield surface for sand (Yu, 1998; McDowell, 2002) gives a good representation of the behaviour, and it has therefore been shown that the sample of discrete particles has been shown to give rise to observed continuum behaviour. The work is, to the author’s knowledge, the first that has shown a DEM soil to show many of the desirable features of sand, in that the sample qualitatively gives normal compression lines and a CSL of the correct slope, which obeys CSSM and which gives a Cam Clay type yield surface in stress space. The work means that the established model can be used in the study of other micro mechanics problems such as particle shape and time effects and the application of DEM to boundary value problems directly.
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19

Zhang, Qiuting. "Mechanics and Functionality of Extreme Mechanical Instabilities through Buckling Driven Delamination." Diss., Temple University Libraries, 2019. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/587760.

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Mechanical Engineering
Ph.D.
Mechanical instabilities such as wrinkling and buckling-driven delamination in thin film-substrate systems have historically been considered as one of structural failure mechanisms, which should be avoided. The past decade has witnesssed rapid growth in harnessing such surface instabilities for a wide range of tunable surface related properties and functionalities, especially in soft materials on small scales. Compared to extensively studied wrinkling on soft substrates and localized buckling driven delamination on stiff substrates, the fundamental mechanics underpinning ordered buckle-delamination on soft substrate over large area and its guidance for potential implications in engineering innovation remain largely to be explored. This thesis aims to partially bridging such a knowledge gap. In this thesis, I exploit how to generate the controllable and globally periodic delaminated buckling patterns in thin films on highly prestrained elastomeric substrates, and then explore the fundamental mechanics of this spontaneous extreme buckling driven periodic delamination, as well as its implications in design of extremely stretchable electronics and interfacial mechanical properties measurement. Compared to wrinkling, one of the benefits of extremely buckling driven delamination is the extraordinarily high aspect ratio of buckles. The large surface roughness and high local curvature could potentially enable extreme surface topographies related properties, such as adhesion, wetting, friction, and optics, as well as augment the extreme stretchability in stretchable optical and electronic devices. In the aim of harnessing this extreme buckling driven delamination, I first explore the formation and evolution of extraordinarily high-aspect-ratio delaminated buckles of thin films on 400% pre-strained elastomers, as well as uncovered the underlying deformation mechanism through combining quantitative theoretical analysis and experimental and numerical approaches. A theoretical framework is developed to describe the formation and evolution process of periodic delaminated buckles, which includes three deformation stages, i.e. onset of localized blisters (Stage I), growth and propagation of delamination (Stage II), and post-buckling after delamination arrest (Stage III). I show that under extreme large compressive strain, the profile of periodic blisters changes from sinusoidal shape to jig-saw-like shape with relative high aspect ratio, which have potential applications for design of extremely stretchable electronics. Equipped with the fundamental mechanics of buckle-delamination in thin films, I then exploit harnessing the spontaneous buckling driven periodic delamination to achieve high stretchability in both metal and silicon films. Experimentally I observe periodic buckle-delaminated patterns over large area, accompanied by highly ordered transversely cracking patterns, which can be theoretically predicted by simple crack fragments model. I hypothesize that when the width of ribbons is set to be equal or smaller than the theoretically predicted crack fragment width, there would be no cracking fragmentation. This criteria for designing crack-free micro-ribbons is further validated by related experiments. Guided by the validated criteria, I successfully design crack-free and spontaneous delaminated ribbons on highly prestrained elastomer substrates, which provides a high stretchability of about 120% and 400% in Si and Au ribbons, respectively. I further extend the buckling instability-based metrology to systematically measure the mechanical properties of 2D organic conjugated polymer nano-films, which have tremendous promising applications in organic integrated circuits, solar cells, and stretchable devices. I develop a new fabrication strategy to generate buckle-delaminated free-standing organic conjugated polymeric (P3BT/C60) nanosheets. Through both experiments and theoretical analysis, I show that the free-standing buckle-delaminated organic P3BT/C60 nanosheets have significant advantages over the traditional spin-coated wrinkled nanosheets, including the enhanced mechanical properties, a higher level of stretchability with lower electrical resistance, and a wider range of controllable wettability modulation.
Temple University--Theses
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20

Schöneboom, Jan Claasen Curd. "Combined quantum mechanical - molecular mechanical calculations on cytochrome P450cam." [S.l. : s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=968865267.

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21

Shan, Lei. "Mechanical interactions at the interface of chemical mechanical polishing." Diss., Georgia Institute of Technology, 2000. http://hdl.handle.net/1853/17774.

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22

Loveless, Thomas A. "Mechanical Properties of Kenaf Composites Using Dynamic Mechanical Analysis." DigitalCommons@USU, 2015. https://digitalcommons.usu.edu/etd/4310.

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Natural fibers show potential to replace glass fibers in thermoset and thermoplastic composites. Kenaf is a bast-type fiber with high specific strength and great potential to compete with glass fibers. In this research kenaf/epoxy composites were analyzed using Dynamic Mechanical Analysis (DMA). A three-point bend apparatus was used in the DMA testing. The samples were tested at 1 hertz, at a displacement of 10 μm, and at room temperature. The fiber volume content of the kenaf was varied from 20%-40% in 5% increments. Ten samples of each fiber volume fraction were manufactured and tested. The flexural storage modulus, the flexural loss modulus, and the loss factor were reported. Generally as the fiber volume fraction of kenaf increased, the flexural storage and flexural loss modulus increased. The loss factor remained relatively constant with increasing fiber volume fraction. Woven and chopped fiberglass/epoxy composites were manufactured and tested to be compared with the kanaf/epoxy composites were manufactured and tested to be compared with the kenaf/epoxy composites. Both of the fiberglass/epoxy composites reported higher flexural storage and flexural loss modulus values. The kenaf/epoxy composites reported higher loss factor values. The specific flexural storage and specific flexural loss modulus were calculated for both the fiberglass and kenaf fiber composites. Even though the kenaf composites reported a lower density, the fiberglass composites reported higher specific mechanical properties.
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23

Sjölin, Malin. "Mechanical and chemical chip pre-treatment in mechanical pulp production." Thesis, Linköping University, The Department of Physics, Chemistry and Biology, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-15169.

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The mechanical pulping industry has been developing throughout the years, due to competitive prices in the electricity market and good accessibility of wood. This has made it possible for such and “expensive” process to further develop. Today, with increasing electricity prizes, it is of great interest to reduce electrical consumption in mechanical pulping industry, since the process consumes large amounts of electricity. Braviken paper mill is starting up a new thermomechanical pulping line, scheduled for start-up in August 2008, which aims to reduce electrical consumption. The new line will include chip pre-treatment equipment such as an impregnator, an Andrtiz Impressafiner (Screw press), a high intensity primary stage refines double disc (DD), and a new low consistency refiner (LC), significantly bigger than those earlier available on the market. This master´s thesis is one out of three Master´s thesis made at Braviken paper mill during spring 2008. They all are connected, and are investigating the possibility to reduce electric energy consumption within TMP production. Master´s thesis concerning high consistency refining was done by Dino Muhic, “High consistency refining of mechanical pulps during varying refining conditions”, and low consistency refining written by Fredrik Johansson “Increased energy efficiency in low consistency refining”.

Chip pre-treatment is to be used to reduce electrical consumption. Mechanical pre-treatment, such as using an Andrtiz Impressafiner demolishes the chips while also making it possible to impregnate the chips with chemicals, the later giving additional possibilities to reduce electricity consumption. Chemical chip pre-treatment decreases the lignin softening temperature, which benefits the refining process, yielding longer and less damaged fibers that will create a fibrous pulp with reduced electrical energy input.The goal for this study was to investigate the effect of alkaline-peroxide on chip pre-treatment by using a design of experiment method, in terms of electric energy consumption for the process, strength properties, opacity and ISO-brightness within the pulp/sheets. The trials were built up as a factorial experiment, with two factors, alkaline and peroxide, with two levels each (high and low). The high level for alkaline was 15 kg/t and 10 kg/t for the low level, and the high level for peroxide was 10 kg/t and 5 kg/t for the low level. This resulted in four trials with two zero-points, and two reference pulps, one normal TMP, thermomechanical pulp, and the other TMP with pressafiner and water.

The trials showed that adding alkaline-peroxide clearly had an impact on pulp properties, such as increased strength properties, fiber length improvements and less shives could be found in the alkaline-peroxide treated pulps. The yield was highest for the normal TMP, about 99% and it decreased with increasing alkaline addition, the lowest value was achieved for the pulps containing the highest dose of alkaline, about 95%. The optical properties were more or less as expected. Opacity had the highest value for the pulps that had been made from chips with the highest total alkaline level. The ISO brightness was highest for pulps containing low level of alkaline. It could not be decided if the electricity demand had been reduced for the chemically treated pulps; it actually had the opposite effect as expected. The chemically treated pulps demanded a higher SEC, specific energy consumption, compared to the reference pulps. This result could have depended on the small pilot plant high consistency refiners at CTP, Centre technique du papier, Grenoble, France, due to the plate size and what kind of plats that were used. To do trials like this and to be able to draw correct conclusions relevant for a full scale plant, bigger refiners might give a more comparable result. It was clear that the fiber properties had improved, which could be the key to reduce electricity when LE- (low-energy) plates are used in the HC-refiner. A higher intensity could be used and electricity energy could be saved.

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Dike, Nnadozie N. F. "Performance of Mechanical and Non-mechanical Connections to GFRP Components." Master's thesis, University of Central Florida, 2012. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/5187.

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There are presently many solutions to dealing with aging or deteriorated structures. Depending on the state of the structure, it may need to be completely over-hauled, demolished and replaced, or only specific components may need rehabilitation. In the case of bridges, rehabilitation and maintenance of the decks are critical needs for infrastructure management. Viable rehabilitation options include replacement of decks with aluminum extrusions, hybrid composite and sandwich systems, precast reinforced concrete systems, or the use of pultruded fiber-reinforced polymer (FRP) shapes. Previous research using pultruded glass fiber-reinforced polymer (GFRP) decks, focused on behaviour under various strength and serviceability loading conditions. Failure modes observed were specific to delamination of the flexural cross sections, local crushing under loading pads, web buckling and lip separation. However certain failure mechanisms observed from in-situ installations differ from these laboratory results, including behaviour of the connectors or system of connection, as well as the effect of cyclic and torsional loads on the connection. This thesis investigates the role of mechanical and non-mechanical connectors in the composite action and failure mechanisms in a pultruded GFRP deck system. There are many interfaces including top panel to I-beam, deck panel to girder, and panel to panel, but this work focuses on investigating the top panel connection. This is achieved through comparative component level shear, uplift, and flexure testing to characterize failure and determine connector capacity. Additionally, a connection of this GFRP deck system to a concrete girder is investigated during the system-level test. Results show that an epoxy non-mechanical connection may be better than mechanical options in ensuring composite behaviour of the system.
ID: 031001297; System requirements: World Wide Web browser and PDF reader.; Mode of access: World Wide Web.; Title from PDF title page (viewed March 7, 2013).; Thesis (M.S.)--University of Central Florida, 2012.; Includes bibliographical references (p. 80-82).
M.S.
Masters
Civil, Environmental, and Construction Engineering
Engineering and Computer Science
Civil Engineering; Structural and Geotechnical Engineering
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25

Conca, Luca. "Mechanical properties of polymer glasses : Mechanical properties of polymer glasses." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSE1050/document.

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Ce manuscrit présente des récentes extensions au modèle PFVD, basé sur l'hétérogénéité de la dynamique des polymères vitreux à l'échelle de quelques nanomètres et résolu par simulation en 3D, afin de fournir une description physique unifiée des propriétés mécaniques et dynamiques des polymères vitreux soumis à déformation plastique. Trois sujets principaux sont traités : La plastification. Sous déformation, les polymères atteignent le seuil de plasticité (yield) à quelques pourcents de déformation et quelques dizaines de MPa. Nous proposons que l'énergie élastique absorbée à l'échelle des hétérogénéités dynamiques accélère la dynamique locale. On observe contraintes ultimes de quelques dizaines de MPa à quelques pourcents de déformation et que la plastification est due à un nombre relativement petit d'événements locaux. Il a été observé que la dynamique devient plus rapide et homogène dans le régime plastique et que la mobilité moyenne atteint une valeur stationnaire, linéaire avec le taux de déformation. Nous proposons que la contrainte locale stimule la diffusion de monomères des domaines lents à ceux rapides (mécanisme de facilitation) et accélère dynamique locale. Ceci permets d'observer l'homogénéisation de la dynamique, avec des caractéristiques proches de l'expérience. L'écrouissage, dans les polymères enchevêtrés ou réticulés. A grande déformation, la contrainte augmente avec une pente caractéristique d'ordre 10 – 100 MPa au-dessous de la transition vitreuse. De manière analogue à une théorie récente, nous proposons que la déformation locale oriente les monomères dans la direction d'étirage et ralentie la dynamique, suite à l'intensification des interactions locales. Les modules d'écrouissage mesurés, les effets de la réticulation et du taux de déformation sont comparables aux données expérimentales. En outre, on trouve que l'écrouissage a un effet stabilisateur sur les phénomènes de localisation et sur les bandes de cisaillement
This manuscript presents recent extensions to the PFVD model, based on the heterogeneity of theh dynamics of glassy polymers at the scale of a few nanometers et solved by 3D numerical simulation, which aim at providing a unified physical description of the mechanical and dynamical properties of glassy polymers during plastic deformation. Three main topics are treated: Plasticization. Under applied deformation, polymers undergo yield at strains of a few percent and stresses of some 10 MPa.We propose that the elastic energy stored at the scale of dynamical heterogeneities accelerates local dynamics. We observe yield stresses of a few 10 MPa are obtained at a few percent of deformation and that plastification is due to a relatively small amount of local yields. It has been observed that dynamics becomes faster and more homogeneous close to yield and that the average mobility attains a stationary value, linear with the strain rate. We propose that stress-induced acceleration of the dynamics enhances the diffusion of monomers from slow domains to fast ones (facilitation mechanism), accelerating local dynamics. This allows for obtaining the homogeneisation of the dynamics, with the same features observed during experiments. Strain-hardening, in highly entangled and cross-linked polymers. At large strain, stress increases with increasing strain, with a characteristic slope (hardening modulus) of order 10 – 100 MPa well below the glass transition. Analogously to a recent theory, we propose that local deformation orients monomers in the drawing direction and slows dows the dynamics, as a consequence of the intensification of local interactions. The hardening moduli mesured, the effect of reticulation and of strain rate are comparable with experimental data. In addition, strain-hardening is found to have a stabilizing effect over strain localization and shear banding
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26

Jenett, Benjamin(Benjamin Eric). "Discrete mechanical metamaterials." Thesis, Massachusetts Institute of Technology, 2020. https://hdl.handle.net/1721.1/130610.

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Thesis: Ph. D., Massachusetts Institute of Technology, School of Architecture and Planning, Program in Media Arts and Sciences, September, 2020
Cataloged from the official PDF version of thesis.
Includes bibliographical references (pages 127-136).
Digital fabrication enables complex designs to be realized with improved speed, precision, and cost compared to manual techniques. Additive manufacturing, for example, is one of the leading methods for rapid prototyping and near net shape part production. Extension to full scale structures and systems, however, remains a challenge, as cost, speed and performance present orthogonal objectives that are inherently coupled to limited material options, stochastic process errors, and machine-based constraints. To address these issues, this thesis introduces new materials that physically embody attributes of digital systems, scalable methods for automating their assembly, and a portfolio of use cases with novel, full-scale structural and robotic platforms. First, I build on the topic of discrete materials, which showed a finite set of modular parts can be incrementally and reversibly assembled into larger functional structures.
I introduce a new range of attainable properties, such as rigidity, compliance, chirality, and auxetic behavior, all within a consistent manufacturing and assembly framework. These discretely assembled mechanical metamaterials show global continuum properties based on local cellular architectures, resulting in a system with scalability, versatility, and reliability similar to digital communication and computation. Next, I present a new kind of material-robot system to enable methods of assembly automation. Rather than relying on global motion control systems for precision, mobile robots are designed to operate relative to their discrete material environment. By leveraging the embedded metrology of discrete materials, these relative robots have reduced complexity without sacrificing extensibility, enabling the robots to build structures larger and more precise than themselves.
Multi-robot assembly is compared to stationary platforms to show system benefits for cost and throughput at larger scales. Finally, I show a range of discretely assembled systems that blur the boundary between structure and robotics. Full-scale demonstrations include statically reconfigurable bridges, supermileage racecars, and morphing aero and hydrodynamic vehicles. Performance scaling is projected to new regimes, using case studies of turbine blades, airships, and space structures. These discrete systems demonstrate new, disruptive capabilities not possible within the limits of traditional manufacturing.
by Benjamin Eric Jenett.
Ph. D.
Ph.D. Massachusetts Institute of Technology, School of Architecture and Planning, Program in Media Arts and Sciences
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27

McCrate, Mark P. "Modern Mechanical Automata." University of Cincinnati / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1291146053.

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28

Levin, Ari. "Modelling mechanical systems." Master's thesis, University of Cape Town, 1999. http://hdl.handle.net/11427/19420.

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Education should be one of the highest priorities of any country. The ability to pass on knowledge and understanding effectively is a sign of a good educational system. From an engineering perspective, better teaching tools allow for greater understanding by the students making them better engineers. Educational aids have been with us for a long time. Inventions from the abacus to the personal computer, have aided engineering students in faster understanding and application of their work. These aids are costly and sometimes become affordable only when outdated and redundant. A low-cost device that does not date would be the educationalist's ideal solution. To this end, a concept model of a conveyor sorting system was developed using Lego as the design medium. The model is a conveyor belt along which coloured blocks are sorted into bins by pneumatic cylinders. The model is controlled by a personal computer and the Lego interface box. The software is written in Visual Basic.
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Otte, Alexander-Nikolaj. "Combined quantum mechanical, molecular mechanical investigation of enantioselective reactions in lipases." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=980565707.

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Yasuda, Koji, and Daisuke Yamaki. "Simple minimum principle to derive a quantum-mechanical/molecular-mechanical method." American Institute of Physics, 2004. http://hdl.handle.net/2237/8738.

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31

Aryaei, Ashkan. "Mechanical Properties of Bio-nanocomposites and Cellular Behavior under Mechanical Stimulation." University of Toledo / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1398361357.

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32

Shooter, Steven B. "Information modeling in mechanical design : with application to cam mechanical design /." Diss., This resource online, 1995. http://scholar.lib.vt.edu/theses/available/etd-06062008-155414/.

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33

Parker, Eleanor. "Mechanical loading and cartilage physiology." Thesis, University of Westminster, 2011. https://westminsterresearch.westminster.ac.uk/item/8zzqy/mechanical-loading-and-cartilage-physiology.

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Whilst mechanical impact is known to be essential for cartilage maintenance, it has been noted that altered joint loading and increased force may lead to cartilage degradation and increase the risk for the development of osteoarthritis (OA). This study investigated the cellular responses of chondrocytes to mechanical impact, and the effects of possible chondroprotective agents for OA preventative strategies in individuals exposed to high impact, repetitive loading. Single-impact mechanical trauma (force 1.14 N, pressure 6.47 KPa) was determined to induce biphasic decrease in cell volume to 647.38±60.38 μm3 at 2 h and 516.52±38.86 μm3 at 48 h, the initial phase of which was observed to be an active mechanotransduction mechanism, termed Impact-Induced Volume Decrease (IIVD), and the subsequent phase to be Apoptotic Volume Decrease (AVD). The newly defined IIVD was concluded to be dependent upon the PKC/PLCβ3 pathway, and possibly mediated by intracellular Ca2+ store release and Volume Sensitive Organic Anion Channel (VSOAC) activity. Furthermore, mechanical impact was observed to induce a rapid decrease in F-actin from 1.19±0.13 MU to 0.87±0.02 MU, termed Impact-Induced Actin Decrease (IIAD) and associated with the biphasic rise in cell death at rates of 2.75±0.41 %.h-1 and 0.66±0.03 %.h-1. Both in vivo exercise and in vitro mechanical load induced a release IL-1β (20.67±2.58 % and 5.86±0.21 AU), MCP-1 (25.69±0.53 % and 1.45±0.01 AU) and IL-10 (8.97±2.40 % and 5.55±0.28 AU), with in vivo concentrations correlating with joint magnitude and strike patterns. Decreased levels of IL-1β and MCP-1 (to 9.60±2.34 % and 9.01±2.34 %, respectively) observed in the evening were further confirmed using a hyperosmotic-treated in vitro model of prolonged static-loaded cartilage with evidence for a IL-1β-dominated paracrine loop between articular cartilage and mononuclear phagocytes. In vitro, chondroprotective and antiinflammatory actions of chondroitin sulphate, glucosamine sulphate, REV 5901 and Tamoxifen were associated with a reduction in pre-impact cell volume (average of 31.91±4.19 %) and increased pre-impact actin levels (average of 39.92±9.29 %). Anti-inflammatory agents, curcumin and dexamethasone exhibited less effective chondroprotective actions, via inhibition of IL-1β (average of 83.45±1.30 %) and thus apoptosis. To conclude, high impact exercise is recommended with a place for chondroprotective properties of chondroitin, glucosamine sulphate and/or curcumin in high-risk groups before OA onset.
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Zhang, Qian. "Isothermal mechanical and thermo-mechanical durability characterization of selected pb-free solders." College Park, Md. : University of Maryland, 2004. http://hdl.handle.net/1903/220.

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Thesis (Ph. D.) -- University of Maryland, College Park, 2004.
Thesis research directed by: Mechanical Engineering. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.
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Sul, Onejae Washburn Michael Sean. "Thermally actuated mechanical systems." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2006. http://dc.lib.unc.edu/u?/etd,392.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2006.
Title from electronic title page (viewed Oct. 10, 2007). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Physics and Astronomy." Discipline: Physics and Astronomy; Department/School: Physics and Astronomy.
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Mow-Lowry, Conor. "Opto-mechanical noise cancellation." View electronic text, 2002. http://eprints.anu.edu.au/documents/disk0/00/00/07/65/index.html.

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Thesis (BSc. (Hons))--Australian National University, 2002.
Available via the Australian National University Library Electronic Pre and Post Print Repository. Title from title screen (viewed Mar. 28, 2003). "A thesis submitted for the degree of Bachelor of Science with Honours in physics at the Australian National University" "November 2002" Bibliography: p. 73-75.
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Lillehei, Peter Thomas. "Single molecule mechanical testing." Diss., Georgia Institute of Technology, 2001. http://hdl.handle.net/1853/31044.

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38

Was, Loïc. "Mechanical Engineering for Electronics." Thesis, KTH, Hållfasthetslära (Inst.), 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-103785.

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Schlumberger drilling tools are exposed to very hard loading conditions (shocks, vibrations, thermal cycling) while performing a job. As these tools are full of electronics, issues can quickly come from electronics failure. Mechanisms of failure occurring in electronics are very complex but can be predicted in some cases. The first part of the thesis describes in which context mechanical engineering applied to electronics is used in Schlumberger. The different kinds of failure which will be investigated in the report are presented in this part. The second part deals with fatigue models used in electronics. From classical methods used in mechanical engineering to calculate a material fatigue life, fatigue models are adapted and formulated for special applications. The third part investigates the issue of capacitor flex-cracking which occurs when boards do not remain flat during loadings (shocks or thermal cycling). Root causes of this mechanism of failure are investigated in this part to find key points where improvements have to be made to avoid failure. The fourth part presents a common failure which deals with Plated Through Holes (PTHs) issues. A simple model of investigations is established. The fifth part deals with fatigue life of leadless components (resistors) under thermal cycling. Even if the failure is revealed during shock tests, the damage is mostly created during the thermal cycles applied on the board prior to shock. The effect of the size of the component is discussed in this part. The last part deals with modal analysis on a given board in order to be able to reduce the impact and the damage of shocks applied on this board. Simulation and experimental modal analysis are compared in order to see the influence of certain parameters on the natural frequencies of the board.
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Radcliffe, Torrey Owen 1974. "Mechanical structures interactive laboratory." Thesis, Massachusetts Institute of Technology, 2002. http://hdl.handle.net/1721.1/16833.

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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Aeronautics and Astronautics, 2002.
Includes bibliographical references (p. 53-54).
This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
The Mechanical Structures Interactive Lab is one of a number of new remotely accessible WebLabs being developed at the Massachusetts Institute of Technology. WebLabs allow students access to physical experiments from anywhere at anytime via the World Wide Web. While these cannot replace laboratories that are more traditional, they facilitate lab assignments when traditional labs are not practical. The Mechanical Structures Interactive Laboratory is a framework for allowing remote experimentation on elastic structures. Users of the system are able to obtain data from experiments they perform on the structures form a remote location. The system is designed to allow new experiments to be easily added, and can support all levels of mechanical structures courses currently oered at MIT. The system can be used by multiple courses in multiple departments of multiple universities. Users are only required to have a computer connected to the World Wide Web and they can send actuator commands and monitor sensor responses in near real time. The typical student is expected to spend between fifteen minutes to an hour using the system to obtain experimental data. A queuing system regulates (and allows monitoring of) system usage. All of the software was developed using National Instruments G language. Unlike similar systems, the Mechanical Structures Interactive Lab does not use any sort of Java based applications. The system has been tested in a small graduate course. The students used a piezoelectric actuator to stimulate a beam and monitored the response using strain gauges, laser displacement sensors and a webcam. By using the same computer to both model the beam and perform experiments, the students received rapid feedback on the accuracy of their numerical models. While most of the feedback received was positive, there are still a number of areas for system improvement. While work is still being done to make these improvements, the system has shown itself to be an effective means of providing a positive educational experience to engineering students.
by Torrey Owen Radcliffe.
S.M.
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40

Walsh, Brian Kendall. "Computer-aided mechanical ventilation." Thesis, Rush University, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10111109.

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Statement of the problem: The systematic implementation of evidence-based practice through the use of guidelines, checklists and protocols has been shown to mitigate the risks associated with MV, yet variation in practice remains prevalent. Recent advances in MV, physiologic monitoring, device-to-device communication, computer processing and software engineering have allowed for the development of an automated point-of-care access to real-time goal setting and practice variance identification. Our aim was to assess the utility of a computer-aided MV (CAMV) system that displays variances and scores the overall MV course. Methods: A retrospective categorization of the ventilation and oxygenation statuses of patients within our pediatric intensive care unit (PICU) over a 2 '/z years period utilizing 15 rule-based algorithms was initiated as a proof of concept. Goals were predetermined based on generally accepted values. All patient categories were calculated and presented as a percent of recording time. Following the feasibility study, a retrospective observational study (baseline), followed by two sequential interventions made over a 2-month period was conducted. Phase I comprised a survey of goals of MV by clinicians caring for patients being monitored by the CAMV system. Phase II intervention was the setting and monitoring of goals of MV with a web browser based data visualization system (T3). An outcome measurement tool was developed to score each MV course. The MV score (MVS) evaluated four outcomes: (1) acceptable ventilation, (2) acceptable oxygenation, (3) barotrauma free and (4) volutrauma-free states as a percent of recording time. Results: Pilot consisted of 222 patients. The Baseline phase evaluated 130 patients, Phase I enrolled 31 patients and Phase II enrolled 36 patients. There were no differences in demographic characteristics between cohorts. One hundred and seventy-one surveys were completed in Phase I. An increase in the use of T3 by 87% was observed in Phase II from Phase I. MVS improved by 8.4% in Phase I and 11.3% in Phase II from Baseline. The largest improvement was in the volutraumafree category. MVS was 9% higher on average in those who survived. Conclusion: The use of CAMV was associated with an improvement in MVS. Further research is needed to determine if improvements in MVS through a targeted, process-oriented intervention such as CAMV will lead to improved patient outcomes.

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41

Howe, Kimberly Palazzo. "Mechanical Ventilation Antioxidant Trial." Case Western Reserve University School of Graduate Studies / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=case1112877564.

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42

Chiel, Joshua R. "Natural Mechanical Topological Insulators." Case Western Reserve University School of Graduate Studies / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=case1586315731890489.

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43

Vonderheide, Christopher M. "Laser velocimetric flow mapping and characterization of oil mist nozzles used for blade excitation in high cycle fatigue testing." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 2005. http://library.nps.navy.mil/uhtbin/hyperion/05Sep%5FVonderheide.pdf.

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Thesis (M.S. in Mechanical Engineering)--Naval Postgraduate School, September 2005.
Thesis Advisor(s): Dr. Raymond Shreeve, Dr. Garth Hobson. Includes bibliographical references (p. 61). Also available online.
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44

Fountoukidis, Evangelos. "Thermo-mechanical response of monolithic and NiTi shape memory alloy fiber reinforced Sn-3.8Ag-0.7Cu solder." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 2005. http://library.nps.navy.mil/uhtbin/hyperion/05Sep%5FFountoukidis.pdf.

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45

Hosoglu, Selcuk. "Cellular automata an approach to wave propagation and fracture mechanics problems." Thesis, Monterey, Calif. : Naval Postgraduate School, 2006. http://bosun.nps.edu/uhtbin/hyperion.exe/06Dec%5FHosoglu.pdf.

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Thesis (M.S. in Mechanical Engineering)--Naval Postgraduate School, December 2006.
Thesis Advisor(s): Young W. Kwon. "December 2006." Includes bibliographical references (p. 63-64). Also available in print.
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46

Betancourt, Arturo. "Computational study of the heat transfer and fluid structure of a shell and tube heat exchanger." Thesis, Florida Atlantic University, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10172609.

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A common technique to improve the performance of shell and tube heat exchangers (STHE) is by redirecting the flow in the shell side with a series of baffles. A key aspect in this technique is to understand the interaction of the fluid dynamics and heat transfer. Computational fluid dynamics simulations and experiments were performed to analysis the 3-dimensional flow and heat transfer on the shell side of an STHE with and without baffles. Although, it was found that there was a small difference in the average exit temperature between the two cases, the heat transfer coefficient was locally enhanced in the baffled case due to flow structures. The flow in the unbaffled case was highly streamed, while for the baffled case the flow was a highly complex flow with vortex structures formed by the tip of the baffles, the tubes, and the interaction of flow with the shell wall.

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47

Barry, Matthew M. "Analytical and experimental studies of thermoelectric devices and materials." Thesis, University of Pittsburgh, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10183683.

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Interest in thermoelectric devices (TEDs) for waste-heat recovery applications has recently increased due to a growing global environmental consciousness and the potential economic benefits of increasing cycle efficiency. Unlike conventional waste-heat recovery systems like the organic Rankine cycle, TEDs are steady-state, scalable apparatus that directly convert a temperature difference into electricity using the Seebeck effect. The benefits of TEDS, namely steady-state operation and scalability, are often outweighed by their low performance in terms of thermal conversion efficiency and power output. To address the issue of poor device performance, this dissertation takes a multi-faceted approach focusing on device modeling, analysis and design and material processing.

First, a complete one-dimensional thermal resistance network is developed to analytically model a TED, including heat exchangers, support structures and thermal and electrical contact resistances. The purpose of analytical modeling is twofold: to introduce an optimization algorithm of the thermoelectric material geometry based upon the realized temperature difference to maximize thermal conversion efficiency and power output; and to identify areas within the conventional TED that can be restructured to allow for a greater temperature difference across the junction and hence increased performance. Additionally, this model incorporates a component on the numerical resolution of radiation view factors within a TED cavity to properly model radiation heat transfer. Results indicate that geometric optimization increases performance upwards of 30% and the hot-side ceramic diminishes realized temperature difference. The resulting analytical model is validated with published numerical and comparable analytical models, and serves as a basis for experimental studies.

Second, an integrated thermoelectric device is presented. The integrated TED is a restructured TED that eliminates the hot-side ceramic and directly incorporates the hot-side heat exchanger into the hot-side interconnector, reducing the thermal resistance between source and hot-side junction. A single-state and multi-stage pin-fin integrated TED are developed and tested experimentally, and the performance characteristics are shown for a wide range of operating fluid temperatures and flow rates. Due to the eliminated to thermal restriction, the integrated TED shows unique performance characteristics in comparison to conventional TED, indicating increased performance.

Finally, a grain-boundary engineering approach to material processing of bulk bismuth telluride (Bi2Te3) is presented. Using uniaxial compaction and sintering techniques, the preferred crystallographic orientation (PCO) and coherency of grains, respectively, are controlled. The effect of sintering temperature on thermoelectric properties, specifically Seebeck coefficient, thermal conductivity and electrical resistivity, are determined for samples which exhibited the highest PCO. It is shown the performance of bulk Bi2Te3 produced by the presented method is comparable to that of nano-structured materials, with a maximum figure of merit of 0.40 attained at 383 K.

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Vaidya, Anirudha. "Load-Displacement Relations for an Edge-Cracked Beam with a Hysteretic Bilinear Cohesive Zone Model." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1408958644.

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49

Custer, Erica M. "Cortical Bone Mechanics Technology and Quasi-static Mechanical Testing Sensitivity to Bone Collagen Degradation." Ohio University Honors Tutorial College / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1556281791006274.

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Rigato, Annafrancesca. "Characterization of cell mechanics with atomic force microscopy : Mechanical mapping and high-speed microrheology." Thesis, Aix-Marseille, 2015. http://www.theses.fr/2015AIXM4070/document.

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Abstract:
La mécanique cellulaire a gagné un intérêt croissant en raison de son implication fondamentale dans des nombreux processus cellulaires, notamment la migration, la division, la différentiation et l’apoptose. Entre autres techniques, la microscopie à force atomique (AFM) s’est avérée particulièrement utile pour la caractérisation mécanique des cellules vivantes. Dans cette thèse, deux aspects différents ont été étudiés par AFM. Dans un premier temps, l’élasticité des cellules épithéliales étalées sur des micropatterns adhésifs a été cartographiée. Cette étude montre que l’élasticité d’une cellule varie en fonction de sa géométrie d’adhésion à la fois au niveau global et subcellulaire. La deuxième partie de cette thèse est dédiée à la caractérisation de la réponse viscoélastique d’une cellule à un stimulus mécanique oscillatoire à haute fréquence. Des études précédentes montrent que la réponse des cellules est dominée par un stress élastique et suive une loi de puissance faible à basse fréquence. Une réponse cellulaire essentiellement visqueuse est attendue à haute fréquence, mais jusqu’à présent les limitations techniques ont empêché l’évaluation de cette propriété. Dans ma thèse, ces limitations ont été dépassées grâce à la modification d’un AFM à grande vitesse (HS-AFM). Des mesures de rhéologie active sur fibroblastes ont été réalisées entre 1Hz et 120 kHz, permettant d’étendre de deux ordres de grandeur l’échelle de fréquences explorée. Ce travail montre une réponse cellulaire aux stimulations à haute fréquence plus visqueuse qu’à basse fréquence, mais suggèrent aussi une réponse bien plus complexe qu’attendue
The field of cell mechanics gained a growing interest because of its fundamental implication in several cellular processes, such as migration, division, differentiation and apoptosis. Among other techniques, atomic force microscopy (AFM) demonstrated particularly useful for the mechanical characterization of living cells. In this thesis, two different aspects were investigated by AFM. In the first part, the elastic properties of epithelial cells grown on adhesive micropatterns were mapped. This study shows that the elasticity of a cell varies as a function of the geometry of its adhesive environment on both global and subcellular scales. The second part of this thesis focuses on the characterization of the viscoelastic response of a cell subjected to an oscillatory mechanical stimulus at high frequency. Previous studies show that the response of cells to such stimuli is mainly dominated by elastic stress and follows a weak power law at low frequency. Instead, a predominantly viscous behavior is expected at high frequency. Up to now, technical limitations prevented the experimental validation of this property. In this thesis, these limitations were overcome thanks to the modification of a high-speed AFM (HS-AFM). With this setup, active rheological measurements of living fibroblasts could be performed from 1 Hz to 120 kHz, extending of two orders of magnitude the frequency scale explored until now. This work highlights a response of cells to high-frequency stimuli which is more viscous than at low frequency, but also suggests a more complex response than expected
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