Dissertations / Theses on the topic 'Mechanical Engineering'
To see the other types of publications on this topic, follow the link: Mechanical Engineering.
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 dissertations / theses for your research on the topic 'Mechanical Engineering.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.
1
Was, Loïc. "Mechanical Engineering for Electronics." Thesis, KTH, Hållfasthetslära (Inst.), 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-103785.
Full textAbstract:
Schlumberger drilling tools are exposed to very hard loading conditions (shocks, vibrations, thermal cycling) while performing a job. As these tools are full of electronics, issues can quickly come from electronics failure. Mechanisms of failure occurring in electronics are very complex but can be predicted in some cases. The first part of the thesis describes in which context mechanical engineering applied to electronics is used in Schlumberger. The different kinds of failure which will be investigated in the report are presented in this part. The second part deals with fatigue models used in electronics. From classical methods used in mechanical engineering to calculate a material fatigue life, fatigue models are adapted and formulated for special applications. The third part investigates the issue of capacitor flex-cracking which occurs when boards do not remain flat during loadings (shocks or thermal cycling). Root causes of this mechanism of failure are investigated in this part to find key points where improvements have to be made to avoid failure. The fourth part presents a common failure which deals with Plated Through Holes (PTHs) issues. A simple model of investigations is established. The fifth part deals with fatigue life of leadless components (resistors) under thermal cycling. Even if the failure is revealed during shock tests, the damage is mostly created during the thermal cycles applied on the board prior to shock. The effect of the size of the component is discussed in this part. The last part deals with modal analysis on a given board in order to be able to reduce the impact and the damage of shocks applied on this board. Simulation and experimental modal analysis are compared in order to see the influence of certain parameters on the natural frequencies of the board.
2
Sirizzotti, Michael D. "Mechanical Engineering skills in Canadian industry." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0035/MQ62285.pdf.
Full text
3
Lu, Peter Guang Yi. "Mechanical engineering challenges in humanoid robotics." Thesis, Massachusetts Institute of Technology, 2011. http://hdl.handle.net/1721.1/68535.
Full textAbstract:
Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2011.Cataloged from PDF version of thesis.
Includes bibliographical references (p. 36-39).
Humanoid robots are artificial constructs designed to emulate the human body in form and function. They are a unique class of robots whose anthropomorphic nature renders them particularly well-suited to interact with humans in a world designed for humans. The present work examines a subset of the plethora of engineering challenges that face modem developers of humanoid robots, with a focus on challenges that fall within the domain of mechanical engineering. The challenge of emulating human bipedal locomotion on a robotic platform is reviewed in the context of the evolutionary origins of human bipedalism and the biomechanics of walking and running. Precise joint angle control bipedal robots and passive-dynamic walkers, the two most prominent classes of modem bipedal robots, are found to have their own strengths and shortcomings. An integration of the strengths from both classes is likely to characterize the next generation of humanoid robots. The challenge of replicating human arm and hand dexterity with a robotic system is reviewed in the context of the evolutionary origins and kinematic structure of human forelimbs. Form-focused design and function-focused design, two distinct approaches to the design of modem robotic arms and hands, are found to have their own strengths and shortcomings. An integration of the strengths from both approaches is likely to characterize the next generation of humanoid robots.
by Peter Guang Yi Lu.
S.B.
4
Weston, Nicholas John. "Time estimation in mechanical engineering design." Thesis, Durham University, 1994. http://etheses.dur.ac.uk/1218/.
Full textAbstract:
This thesis describes investigations into the phenomenon of time estimation in mechanical engineering design. Time estimating in this context refers to estimating in advance the approximate duration of a new design project, for the purpose of preparing schedules. The thesis describes background to the estimation problem, including practical and theoretical aspects of design, design management and market conditions. The research presented is based on data gathered from industrial collaborators, therefore detailed descriptions of the collaborating firms are included. A quantitative study is described which demonstrates that current estimation techniques are not infallible; and that there can be a statistically significant link between the estimated and actual completion times. A process of grounded theorising, based on expert interviews, is presented. Models of the design estimation task were generated by this process, and are included. Differences were found in the models for the estimation of times in an Engineer to Order (ETO) environment, and estimation in a Volume Manufacturing environment. The models were corroborated firstly by checking if they could be recognised and endorsed by the experts from which they were generated, and. secondly by checking if they could be recognised and endorsed by an expert not involved in the original model generation. Correspondence was found to be good. A modified model of time estimation is presented, taking into account the findings of the corroboration exercise. Finally, an example of a simple tool for assisting the estimation process is included.
5
Skoblo, T. S., S. P. Romanyuk, and T. V. Maltsev. "Application of nanotechnology in mechanical engineering." Thesis, Sumy State University, 2017. http://essuir.sumdu.edu.ua/handle/123456789/66718.
Full textAbstract:
New technological processes of hardening using nanotechnology have been
developed, tested and used in the manufacture. In this case, an integrated approach
is used in the study, which included constructive solutions at hardening,
application of nano- and micro-sized coatings, the choice of material and
processing technology.
New technologies of hardening are effective for work in friction, corrosion
and fatigue conditions.
6
Go, Shanette A. "Re-engineering engineering : how Course 2-A is paving the way for interdisciplinary engineering education at MIT." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/59911.
Full textAbstract:
Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2010.Cataloged from PDF version of thesis.
Includes bibliographical references (p. 38).
In 2004, The National Academy of Engineers (NAE) released a report calling for changes to be made to the current engineering education system in response to the growing need for engineering graduates who would be able to understand engineering problems in a larger context. The present study hopes to gain a better understanding of the growth of flexible engineering education by determining differences in student characteristics and their effect on a student's choice of academic program, identifying the perceptions of the MIT community of flexible and traditional engineering programs and how these perceptions changed over time, and establishing whether or not a correlation exists between students' perceived self-efficacy in engineering and professional abilities and his or her career plans. An online survey was developed and administered to the Course 2 and Course 2-A student body. Significant differences in motivation, opinion of Course 2 and Course 2-A, as well as perceived self-efficacy were found between Course 2 and Course 2-A students.
by Shanette A. Go.
S.B.
7
Fumis, Cristiana. "Mechanical Wave Propagation in Civil Engineering Materials." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2017.
Find full textAbstract:
Mechanical wave propagation in civil engineering materials is important for different application fields, such as thermal conductivity, damage detection and sound transmission (including filters and sound barriers). A current open challenge is to understand how the chemistry and microstructures of cementitious materials impact the propagation of mechanical waves in them.
The challenge is heightened by the fact that cementitious materials are very heterogeneous at the microscale. In this project, molecular and nanoparticle based simulations will be used in order to construct microstructures of cement hydrates with a range of chemistries and morphologies. I will simulate the dynamic behaviour of these model structures and quantify it in terms of vibrational band structure and density of states. This will open
the way to a new and fundamental understanding of how the chemistry and microstructure of cementitious materials can be tailored in order to engineer their vibrational behaviour, for controlled thermal conductivity, soundroof applications, and more efficient damage detection.
8
Zalatan, Kim (Kim E. ). "Using Adobe Illustrator for mechanical engineering design." Thesis, Massachusetts Institute of Technology, 2011. http://hdl.handle.net/1721.1/68935.
Full textAbstract:
Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2011.Cataloged from PDF version of thesis.
Includes bibliographical references (p. 23-24).
Sketching by hand is important in the creative process because it promotes reinterpretation through ambiguity. Adobe Illustrator is a valuable tool for an engineer to make professional-looking presentation drawings. The project conducted as this thesis was to create a website tutorial to teach students at Massachusetts Institute of Technology enrolled in 2.009, the senior capstone product design course, the basics of Illustrator. A study was conducted on two subjects to judge the effectiveness of the website tutorial project at teaching how to use Illustrator. The subjects had no previous experience with the program. Both of these subjects were able to learn the basics of Illustrator and create a simple logo design in under two hours. They reported that the tutorial gave them enough knowledge of the program to then experiment on their own to continue learning Illustrator. While this tutorial is not meant to teach all aspects of the program, it has been shown to be effective at teaching people with no Illustrator background how to create a simple but useful design that could function in the scope of 2.009.
by Kim Zalatan.
S.B.
9
Sittichokechaiwut, Anuphan. "Dynamic mechanical stimulation for bone tissue engineering." Thesis, University of Sheffield, 2010. http://etheses.whiterose.ac.uk/14959/.
Full textAbstract:
Mechanical loading is an important regulatory factor in bone homeostasis, and plays an essential role in maintaining the structure and mass of bone throughout a lifetime. Although the exact mechanism is unknown the data presented in this thesis supports the concept that substrate signals influence MSC growth and differentiation. A better understanding of the cellular and molecular responses of bone cells to mechanical stimuli is the key to further improvements to therapeutic approaches in orthopaedics, orthodontics, periodontics, bone repair, bone regeneration, implantology and tissue engineering. However, the mechanisms by which cells transduce mechanical signals are poorly understood. There has also been an increased awareness of the need for improvement and development of 3-D in vitro models of mechanotransduction to mimic the 3-D environment, as found in intact bone tissue and to validate 2-D in vitro results. The aims of the project were (i) to optimize a model system by which bone cells can survive in 3-D static culture and their responses to mechanical stimuli can be examined in vitro, (ii) to test the effects of intermittent mechanical compressive loading on cell growth, matrix maturation and mineralization by osteoblastic cells, (iii) to examine the role of the primary cilia, (iv) to assess the effect of dynamic compressive loading on human mesenchymal stem cells in the 3-D environment. The optimized model system has the potential to be used in in vitro studies of bone in 3-D environments including a better understanding of the mechanically controlled tissue differentiation process and matrix maturation in the engineered bone constructs. It has less complicated equipment and techniques compared to dynamic seeding and culture systems making it easy to use in the laboratory. In addition, cells are not pre stimulated by any mechanical stimuli during seeding and culture which enables the researcher to study selected mechanical stimuli and mechanotransduction in bone tissue constructs. The model can mimic the bone environment providing a better physiological model than cells cultured in 2-D monolayer. Using our 3-D system, several loading regimens were compared and it was shown that intermittent short periods of compressive loading can improve cell growth and/or matrix production by MLO-A5 osteoblastic cells during 3-D static culture. This VI suggests that the cells are responding to the mechanical compression stimulus either by directly sensing the substrate strain or the fluid shear stress induced by flow through the porous scaffold. We also demonstrated that our mechanical loading system has the potential to induce osteogenic differentiation and bone matrix production by human MSCs in the same way as treatment with dexamethasone. Although the exact mechanism is unknown the data presented supports the concept that the dynamic compressive loading influence MSC growth, differentiation and production. In further experiments, we used the optimized 3-D model system to study the effects of mechanical loading on primary cilia, which have recently been shown to be potential mechanosensors in bone. We demonstrated that mature cells lacking a cilium were less responsive, less able to upregulate matrix protein gene expression and did not increase matrix production in response to mechanical stimulation suggesting that the primary cilia are sensors for mechanical forces such as fluid flow and/or strain induced shear stress.
10
Nickerson, Charles Sellers Tirrell David A. "Engineering the mechanical properties of ocular tissues /." Diss., Pasadena, Calif. : California Institute of Technology, 2006. http://resolver.caltech.edu/CaltechETD:etd-03172005-145045.
Full text
11
Morris, David T. "Mechatronics for sophomore-level mechanical engineering students." Morgantown, W. Va. : [West Virginia University Libraries], 2000. http://etd.wvu.edu/templates/showETD.cfm?recnum=1525.
Full textAbstract:
Thesis (M.S.)--West Virginia University, 2000.Title from document title page. Document formatted into pages; contains ix, 147 p. : ill. (some col.) Includes abstract. Includes bibliographical references (p. 130-133).
12
Blackstone, Britani Nicole. "Biomaterial, Mechanical and Molecular Strategies to Control Skin Mechanics." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1406123409.
Full text
13
Lai, Jiun-Yu. "Mechanics, mechanisms, and modeling of the chemical mechanical polishing process." Thesis, Massachusetts Institute of Technology, 2001. http://hdl.handle.net/1721.1/8860.
Full textAbstract:
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2001.Includes bibliographical references.
The ever-increasing demand for high-performance microelectronic devices has motivated the semiconductor industry to design and manufacture Ultra-Large-Scale Integrated (ULSI) circuits with smaller feature size, higher resolution, denser packing, and multi-layer interconnects. The ULSI technology places stringent demands on global planarity of the Interlevel Dielectric (ILD) layers. Compared with other planarization techniques, the Chemical Mechanical Polishing (CMP) process produces excellent local and global planarization at low cost. It is thus widely adopted for planarizing inter-level dielectric (silicon dioxide) layers. Moreover, CMP is a critical process for fabricating the Cu damascene patterns, low-k dielectrics, and shallow isolated trenches. The wide range of materials to be polished concurrently or sequentially, however, increases the complexity of CMP and necessitates an understanding of the process fundamentals for optimal process design. This thesis establishes a theoretical framework to relate the process parameters to the different wafer/pad contact modes to study the behavior of wafer-scale polishing. Several models of polishing - microcutting, brittle fracture, surface melting and burnishing - are reviewed. Blanket wafers coated with a wide range of materials are polished to verify the models. Plastic deformation is identified as the dominant mechanism of material removal in fine abrasive polishing.
(cont.) Additionally, contact mechanics models, which relate the pressure distribution to the pattern geometry and pad elastic properties, explain the die-scale variation of material removal rate (MRR) on pattern geometry. The pad displacement into low features of submicron lines is less than 0.1 nm. Hence the applied load is only carried by the high features, and the pressure on high features increases with the area fraction of interconnects. Experiments study the effects of pattern geometry on the rates of pattern planarization, oxide overpolishing and Cu dishing. It was observed that Cu dishing of submicron features is less than 20 nm and contributes less to surface non-uniformity than does oxide overpolishing. Finally, a novel in situ detection technique, based on the change of the reflectance of the patterned surface at different polishing stages, is developed to detect the process endpoint and minimize overpolishing. Models that employ light scattering theory and statistical treatment correlate the sampled reflectance with the surface topography and Cu area fraction for detecting the process regime and endpoint. The experimental results agree well with the endpoint detection schemes predicted by the models.
by Jiun-Yu Lai.
Ph.D.
14
Laskowski, Christina Marie. "Using a product engineering process to manage an introductory mechanical engineering program." Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/32949.
Full textAbstract:
Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2005.Vita.
Includes bibliographical references (leaf 78).
"Discover Mechanical Engineering" (DME) is a student-run Freshman Pre-Orientation Program at the Massachusetts Institute of Technology which, in the time since its inception in 2002, has developed into a popular, professional, and well-organized pre-orientation program MIT. Yet despite its success, it routinely experiences difficulties with respect to personnel and timeframes, both of which continually threaten the well-being of the program. It appears, however, that such difficulties are not a result of the students' motivational level, since all of DME's student volunteers contribute a great deal of time to the program. Rather, the problem may be that DME student leaders (and their supporting volunteers) are attempting to run the program prior to having taken MIT's Product Engineering Process course (also known as 2.009), a required senior-year mechanical engineering course which is expressly designed to teach students how to manage projects similar to DME. This course teaches tools most useful for the management of personnel and of time - the very areas which DME seeks to improve - through the use of Gantt charts, delineation of the project's critical path, and sundry other methods.
(cont.) It is reasonable to believe that bringing a Product Engineering Process methodology to DME would help rectify existing problems, thereby benefiting the program as a whole. This thesis studies the DME program, examines PEP approaches as potential solutions to recurring problems, and suggests several areas for further improvement of DME as a whole.
by Christina Marie Laskowski.
S.B.
15
Hertzberg, Ellen. "International marketing in the heavy mechanical engineering industry." Thesis, University of Strathclyde, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266184.
Full text
16
Das, Patricia (Patricia Adalia), and Mo Roget. "Creating a materials library for mechanical engineering students." Thesis, Massachusetts Institute of Technology, 2017. http://hdl.handle.net/1721.1/112580.
Full textAbstract:
Thesis: S.B., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2017.Cataloged from PDF version of thesis.
Includes bibliographical references (page 47).
A material can enhance or distract from the end-user experience and is an important decision for designers. As such, material libraries exist to provide designers with a hands-on resource to understanding materials beyond just data sheets. When we took 2.009, a mechanical engineering capstone class, we found it difficult to decide which materials to use. Thus, in this work, we sought to create a materials library under an engineering context for student product designers to use. To understand how material libraries function and which materials would best suit the collection, we benchmarked three physical and one virtual material library. We also sought input from those involved in product design classes, such as past students, Professor Wallace who teaches 2.009, and Pappalardo shop staff who support the students in their creations. We also looked at past receipts to supplement our knowledge as well as looked at distributors and what they offered to expand our selection. Our six main categories of materials were: woods, metals, composites, polymers, fabrics, and Smooth-On products. The material libraries key criteria were to be well organized, portable, and useful. We went through several design sketches before deciding on utilizing a modular wire rack so we could place dividers and shelves as necessary. A coding system was also implemented that included main categories and subcategories with associated colors to help with the user experience of quickly locating, using, and returning. Each material comes attached with information and a more complete overview is located in an information packet. While this first version the materials library was met with excitement, it is by no means complete. As such, there are also a number of ways to improve the experience and the collection.
by Patricia Das and Roget Mo.
S.B.
17
Sokoloski, Aaron M. "A common-sense reasoning system for mechanical engineering." Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/32921.
Full textAbstract:
Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2005.Includes bibliographical references (p. 63-64).
This thesis describes the Mechnet system, which was created to test an implementation of analogy-based reasoning about mechanical engineering, focusing on tools and machines that would be found in a shop. Mechnet uses common-sense data about how these things are used and what they are made of, and attempts to judge which objects are similar to each other. The goal was to make "sensible" analogies about things, in that they make sense to a human who has experience in this area. Results show some reasonable analogies for many tools and machines entered, but non-sensical analogies in several instances. The problems which cause these non-sensical analogies are discussed and analyzed. Recommendations are made for improvement; and further research into other kinds of common-sense reasoning.
by Aaron M. Sokoloski.
S.B.
18
Lee, Elaine Linda. "Mechanical Conditioning of Cell Layers for Tissue Engineering." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1322758337.
Full text
19
Drexler, Jason. "Materials Engineering for Enhanced Tissue Scaffold Mechanical Properties." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1275492023.
Full text
20
Franks, Oswald Schweitzer Wesley. "Utilization of mechanical engineering manpower in South Africa." Master's thesis, University of Cape Town, 1989. http://hdl.handle.net/11427/8392.
Full textAbstract:
Includes bibliographical references.The South African economy is currently experiencing a slow growth rate as a result of amongst other things, a shortage of engineers and technicians. This study sets out to investigate the present utilization and shortage of mechanical engineers. It was felt that with a comprehensive knowledge of the utilization of mechanical engineers, industrialists would be better equipped to improve productivity by taking the necessary steps to ensure effective utilization of engineering manpower. The study gathered empirical data, by means of a survey, from seven hundred and sixty seven (767) respondents located throughout South Africa. The study established that the present utilization of mechanical engineers is about sixty (60) percent and that the most probable cause of the poor utilization is a lack of sufficient technical support staff for the engineer.
21
Muzumdar, Manoj D. (Manoj Deepak) 1976. "ICEMENDR : intelligent capture environment for mechanical engineering drawing." Thesis, Massachusetts Institute of Technology, 1999. http://hdl.handle.net/1721.1/9470.
Full textAbstract:
Thesis (M.Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1999.Includes bibliographical references (p. 45-46).
I designed and implemented an intelligent environment for recognizing simple mechanical engineering sketches. This involves the analysis of complex mechanical engineering parts and their components and consists of creating a hierarchical recognition system capable of parsing these parts with simpler geometric primitives. The system seeks to provide an intuitive pencil-and-paper-like interface for sketch recognition by allowing incremental recognition of what a user draws on the system. The system's knowledge is arranged in simple Recognizer modules that have very specialized information on a particular aspect of recognizing a part.
by Manoj D. Muzumdar.
M.Eng.
22
Hayes, Alex John Cullen. "Mechanical Behaviour of Tendinopathic Tendon: An Engineering Perspective." Thesis, Curtin University, 2017. http://hdl.handle.net/20.500.11937/75135.
Full textAbstract:
Tendinopathy is a debilitating disease affecting millions of people worldwide. The aetiology of this disease is not well understood, and treatment remains difficult due to a lack of evidence-based management. This dissertation sought to quantify the mechanical behaviour of tendon in order to understand the difference between healthy and tendinopathic tendons. The findings in this dissertation offer insights that may contribute toward the development of better clinical management of tendinopathy.
23
TESTA, STEFANO. "Engineering musculoskeletal tissue upon mechanical and chemical inducement." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2016. http://hdl.handle.net/2108/201710.
Full text
24
Kleinauskas, Marius. "Dviračio vairo statinio stiprumo ir standumo tyrimai." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2006. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2006~D_20060614_011209-33463.
Full textAbstract:
Kleinauskas M. Research of static strenght and rigidity for wheel of bicycle: Master there is of mechanical engineer/ research advisor S.Rimovskis; Šiauliai University, Technology Faculty, Mechanical Engineering Department. – 2006. – 37p. In the countries of world bicycle is not only a widely used commodity, means of transport, but an index of mode of life. This work analyses a very important part of bicycle construction – a wheel. Strength and rigidity analysis are made using analytical and numerical solving methods. The main purposes of solving are elastic stress distribution in the wheel and the maximum value of the residual deflection. The condition and magnitude of load were estimated according to standard DIN 97100. Received results show if the wheel exploitation reliability is good ant its parameters meet the requirements of standards. The aim of the research: to prepare the methods of bicycle wheel strength and rigidity analysis for researches. Using the programme package ANSYS, to make wheel construction FEM model and perform strength and rigidity numerical solving, estimating of elastic plastic loading conditions.
25
Balakrishnan, AnandKumar. "Concurrent engineering : models and metrics." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0004/MQ43995.pdf.
Full text
26
Abbott, Jonathan E. "Engineering balance : the conceptual approach." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/89875.
Full textAbstract:
Thesis: S.B., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2014.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
Cataloged from student-submitted PDF version of thesis.
Includes bibliographical references (page 59).
This work presents a view of balance useful for mechanical engineers. Mechanical engineers often need to make quick intelligent decisions using conceptual and physical understanding. The typical mechanical engineering instruction usually provides a good basis for "back of the envelope" calculations, especially for mechanical systems; however, one exception to this case is in the field of dynamics and control. Dynamics and control is generally taught with much math, modelling most systems with differential equations. Although math is useful for designing control systems, when designing products for people who act as sophisticated controllers the engineer needs a more general understanding of balance. This work presents a conceptual intuitive way to break the act of balance into distinct mechanisms and thereby quickly evaluate how a system balances.
by Jonathan E. Abbott.
S.B.
27
Li, Hao. "Fatigue Based Structural Design Exploration via Engineering Data Analytics." Wright State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=wright1408364648.
Full text
28
Tseng, Tiffany. "Spatial-visual skills and engineering design." Thesis, Massachusetts Institute of Technology, 2009. http://hdl.handle.net/1721.1/54486.
Full textAbstract:
Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2009.Cataloged from PDF version of thesis.
Includes bibliographical references (p. 49-50).
The purpose of this study was to determine whether students with strong spatial-visual skills tend to design more complex mechanisms for the undergraduate course Design and Manufacturing I. The Purdue Spatial Visualization Test was administered to 137 students enrolled in the course. Test scores were compared to student self-evaluations of experience with tasks associated with spatial reasoning such as building origami models and sketching. The complexity of 34 student robots was analyzed using metrics such as the percentage of moving components in the mechanism. Gender differences in scores on the spatial visualization test were significant, consistent with results of prior studies. A significant correlation between spatial reasoning and origami experience was found for male students tested. Most mechanism complexity criteria were not found to be significantly correlated with spatial-visual ability, although the correlation between the percentage of moving components and spatial test scores approached significance with a negative correlation. These results suggest that strong spatial-visual abilities may be used to simplify engineering design rather than increase its complexity.
by Tiffany Tseng.
S.B.
29
MacLennan, Iain James. "Two parameter engineering fracture mechanics." Thesis, University of Glasgow, 1996. http://theses.gla.ac.uk/6756/.
Full textAbstract:
The object of this work was to investigate and expand on previously carried out research into elastic-plastic crack tip fields using the first two terms of the Williams expansion to characterise the degree of crack tip constraint. As a precursor to this research a history of fracture mechanics is also presented. In the present work crack tip fields in small scale yielding have been detennined using modified boundary layer formulations in an attempt to model the influence of the second order term of the Williams expansion, the T -stress. The prime object of this thesis was to investigate and expand on previously carried out research into a two parameter characterisation of elastic-plastic crack tip fields using the second parameter of the Williams expansion(T), which attempts to characterise the degree of crack tip constraint. Modified Boundary Layer formulations in conditions of plane strain were implemented to derive a suitable reference solutions, against which the effects of out of plane strains can be compared and the validity of presently established reference fields can be gauged. The effect of out of plane non-singular stress, S, on the crack tip stress field were also considered, where constraint was largely determined by T. A wide range of analyses have been carried out, from the microstructural scale to complete engineering components in an attempt to characterise crack tip stress fields. The ability to apply two parameter fracture concepts to real engineering structures requires methods for calculating T for complex components with realistic semi-elliptical defects. A simple engineering method for achieving this was developed making use of linespring elements in the finite element package ABAQUS. This approach was validated by the calculation of T for semi-elliptical cracks at the chord-brace intersection of a tubular welded joint, modelled using the mesh generation program PATRAN. The micromechanics of cleavage, using the Ritchie-Knott-Rice model have also been constructed. This work relates the ratio of J for unconstrained and constrained geometries to critical microstructural distance, critical cleavage stress and the toughness ratio on the strainhardening effect. The elastic-plastic behaviour of short and deeply cracked bend bars has previously been described by Betegon and Hancock based on the first two terms of the Williams expansion. A local cleavage criterion has been applied to these fields to indicate the effect of loss of constraint on lower shelf toughness of shallow cracked bend bars. The work models the maximum temperature at which cleavage can occur in these geometries to show the effect of constraint and aJW ratio of cracked bend bars on the ductile-brittle transition temperature. This has also been backed by a significant experimental research program. Finally constraint dependent toughness has been considered in relation to failure assessment methodologies. A simple engineering method for modifying these Failure Assesssment Diagrams has been presented, this consists of considering the constraint matched toughness of the strucutre. This procedure recovers the original Failure Assessment Line and unifies the constraint dependent fracture toughness within defect assessment schemes which utilise Failure Assessment Diagrams.
30
Aoun, Laurene. "Mechanical properties of growing microtumors : engineering microdevices for the mechanical investigation of tumor spheroids models." Toulouse 3, 2014. http://www.theses.fr/2014TOU30137.
Full textAbstract:
Le développement tumoral est influencé par des signaux biochimiques mais également biomécaniques. Plusieurs études ont montré que la modification de l'environnement mécanique peut moduler la croissance tumorale des cellules, la migration, l'invasion ainsi que la prolifération et l'apoptose. Cependant, les propriétés mécaniques intrinsèques des tumeurs sont elles peu connues. Le sphéroïde est un modèle multicellulaire reproduisant l'organisation des cellules dans une tumeur par les interactions cellule-cellule et cellule-microenvironnement. Afin d'étudier les propriétés mécaniques des sphéroïdes, mon projet était de déterminer les forces exercées par des sphéroïdes tumoraux en cours de croissance. Dans cet objectif, j'ai développé des micropilliers en PDMS, de rapport de forme élevé et démontré qu'ils se comportent comme des capteurs de force. Nous avons mesuré les forces générées par des sphéroïdes de cancer mammaire et nous avons constaté que la croissance des sphéroïdes induit un déplacement croissant des piliers avec le temps et que les forces correspondantes sont de l'ordre de quelques centaines de nanoNewtons. Nous avons trouvé que les forces générées dépendent de la rigidité de l'obstacle environnant, ce qui s'est traduit par la génération des forces plus grandes envers des micropiliers plus rigides. L'ensemble de ces résultats montre que les sphéroïdes en croissance sont capables de détecter leur micro-environnement et générer des forces en fonction de la résistance du dispositif. L'utilisation de ces microdispositifs comme des microcapteurs de force ouvre de nouvelles perspectives dans les domaines de la mécanique des tissus et en pharmacologie anti-tumoraleTumor growth and progression is influenced not only by biochemical cues but also biomechanical ones. Several studies have shown that the modification of the mechanical environment can modulate tumour cell growth, migration and invasion as well as proliferation and apoptosis. However, little is known about the intrinsic tumour mechanical properties. Spheroids provide a unique 3 dimensional model to study the mechanical properties of tumors since they reproduce the organization of a microtumour in cell-cell and cell-microenvironment interactions. In order to investigate the mechanical properties of spheroids, my project was to determine the forces exerted by tumor spheroids during growth. This was done by engineering biocompatible high aspect ratio PDMS microdevices, using microfabrication technics. We showed that these micropillars serve as force sensors. We have measured the forces generated by mammary cancer cells spheroids and we demonstrated that spheroids under growth induce increasing pillars displacement with time and that the corresponding forces are of the order of a few hundred nanoNewtons. We found as well that the generated forces depend on the rigidity of the surrounding obstacle, which was reflected by the generation of increased forces towards more rigid micropillars. The ensemble of these results shows that growing spheroids are able to sense their microenvironment and generate forces according to the resistance of the device. The use of these microdevices arrays as force microsensors opens new prospects in the fields of tissue mechanics and pharmacological drug screening
31
Johnson, Anthony. "Sustainability - its incorporation into the mechanical engineering design process." Thesis, University of Huddersfield, 2014. http://eprints.hud.ac.uk/id/eprint/24275/.
Full textAbstract:
As an engineering design practitioner both as an educator as well as a practicing design consultant it became clear that there was a need for a sustainability measurement tool for the mechanical engineering product designer who actually designs products, that is, the engineer who drives the Computer Aided Design (CAD) station. This need was confirmed upon consulting several publications but in particular the codes of practice of the Institution of Mechanical Engineers, (I.Mech.E.) [A1.1], American Society of Mechanical Engineers (ASME) [A1.2], and The Royal Society of Engineers (RSoC) [A1.3], who prominently advocate sustainability practices to member engineers. This research project aims were formulated to derive a sustainability measurement system for new products across the entire product life cycle. The process of design was used as the system driver with ISO Standards as the system regulator. The adopted technique was to use Embodied Energy as the measurement parameter and aggregate its application to the product throughout the entire product life cycle. Furthermore, saved or generated energy was accrued and used to offset the Embodied Energy input, resulting in an energy balance sheet. A computer algorithm was devised to collect, collate and disseminate the life cycle wide generated data. A control and guidance system was also required and evolved into a top down management system from CEO to the manual worker and governed by ISO Standards.
32
Riedel, Johann Christian Karl Henry. "Design-production interface in the UK mechanical engineering industry." Thesis, University of Wolverhampton, 1994. http://hdl.handle.net/2436/90562.
Full text
33
Barnard, Graham. "Engineering with small roundwood : its mechanical and physical characteristics." Thesis, University of Surrey, 2001. http://epubs.surrey.ac.uk/955/.
Full text
34
Mosleh, Mohsen. "Minimization of mechanical aspects of friction through surface engineering." Thesis, Massachusetts Institute of Technology, 1994. http://hdl.handle.net/1721.1/34097.
Full text
35
Robie, Bruce Harshaw. "Conceptual design by individuals and groups in mechanical engineering." Case Western Reserve University School of Graduate Studies / OhioLINK, 1991. http://rave.ohiolink.edu/etdc/view?acc_num=case1055787080.
Full text
36
Pg-Ya'akub, Dk S. R. "The impact of online learning : mechanical engineering education perspectives." Thesis, Loughborough University, 2018. https://dspace.lboro.ac.uk/2134/33520.
Full textAbstract:
An emerging issue in both the mechanical engineering field and almost all other study disciplines is online learning. Many universities have changed their teaching strategies and are investing heavily in the online presentation of coursework without much investment dealing with lecturers. The migration from a traditional learning technique to online learning has grown rapidly over time. However, the problem is whether all students are ready for the transition from traditional face to face learning to online learning. This research explores the impact of an online learning approach within the mechanical engineering context. The focus of this study was to identify the improvement in the satisfaction, performance and self-confidence of the mechanical students in learning the Mechanical Engineering Design module using the online method. There are four stages involved in this research work. The first stage was problem discovery involving review of related literature and a preliminary study conducted to investigate the student experiences and teacher perceptions on the existing learning techniques for the mechanical design process. This preliminary study also aimed to identify the difficulties and problems faced by students that have resulted in the suggestion of a learning approach using computer technology. The second stage involved the designing and developing of a new prototype web-based learning system. A System Development Life Cycle model (SDLC) was applied comprising four phases of a concept, design, coding and testing. The third stage was the implementation and data collection. A main study was conducted with 160 mechanical engineering students from three different levels of study at one of the universities in Brunei Darussalam. Finally, the fourth stage was data analysis using SPSS statistical software. Based on the main findings, a significant difference was found between the experienced and inexperienced students in terms of their learning satisfaction in using online learning. Significant differences were also identified in terms of time taken between the experienced and inexperienced students when using traditional and online techniques of learning to solve the simple task. Additionally, the findings also indicated that there were significant differences among the experienced and inexperienced students in terms of marks performance in solving complex tasks using the online web-based learning system. The study has shown that the online learning approach is expected to be useful as an additional learning tool to the existing traditional learning technique, particularly in the context of engineering education.
37
Aryaei, Ashkan. "Mechanical Properties of Bio-nanocomposites and Cellular Behavior under Mechanical Stimulation." University of Toledo / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1398361357.
Full text
38
Noll, Scott Allen. "Residual stress fields due to laser-pulse-generated shock waves." The Ohio State University, 1999. http://rave.ohiolink.edu/etdc/view?acc_num=osu1407411599.
Full text
39
Katiyar, Pushkar. "PROCESSING, MICROSTRUCTURAL AND MECHANICAL CHARACTERIZATION OF MECHANICALLY ALLOYED Al-Al2O3 NANOCOMPOSITES." Master's thesis, University of Central Florida, 2004. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/4496.
Full textAbstract:
Aluminum-alumina nanocomposites were synthesized using mechanical alloying of blended component powders of pure constituents. This study was performed on various powder mixtures with aluminum as the matrix and alumina as the reinforcement with volume fractions of 20, 30, and 50 % and Al[subscript 2]O[subscript 3] particle sizes of 50 nm, 150 nm, and 5 [mu]m. X-ray diffraction (XRD) and scanning electron microscopy (SEM) techniques were used for the crystal structure and microstructural characterization of the powders at different stages of milling. Al?O? powders with 50 nm and 150 nm particle size were predominantly of [gamma]-type, while Al[subscript 2]O[subscript 3] of 5 [mu]m size was of [alpha]-type. The main goal was to achieve uniform distribution of the Al?O? ceramic particles in the Al matrix, which was achieved on milling for 24 h in a SPEX mill or 100 h in a Fritsch Pulverisette planetary ball mill. The powders were consolidated in two stages: pre-compaction at room temperature followed by vacuum hot pressing (VHP) or hot isostatic pressing (HIP) techniques to a fully dense condition. The effect of reinforcement particle size and volume fraction on the stress-strain response, elastic modulus and yield strength of the composites was investigated. Nanoindentation and compression tests were performed to characterize the composite material. Yield strength of 515 MPa, compressive strength of 685 MPa and elastic modulus of 36 GPa were obtained from compression tests. Nanoindentation results gave the yield strength of 336 MPa, maximum shear stress of 194 MPa and an elastic modulus of 42 GPa. The low elastic modulus values obtained from the above tests might be because of localized yielding possibly due to residual stresses.M.S.
Department of Mechanical, Materials and Aerospace Engineering;
Engineering and Computer Science
Materials Science and Engineering
40
Trapp, Thomas Alan 1966. "Shipboard integrated engineering plant survivable network optimization." Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/100150.
Full textAbstract:
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2015.Cataloged from PDF version of thesis.
Includes bibliographical references (pages 181-186).
Due to the complexity of naval ship systems, and the iterative nature of classical design, the U.S. Navy has struggled to meet the spirit of Cost-as-an-Independent Variable (CAIV) policy. In particular, distinguishing between best-value concept variants is not well suited to Pareto-style tradeoff analysis unless the variants can be shown to be at or approximately minimum cost. This thesis presents a systematic process for minimum cost, survivable design of an integrated engineering plant (IEP). The mathematical optimization techniques used are suitable for early-stage design. There are three major contributions of this work. First, a straightforward method for "designed-in" survivability of early stage concepts at guaranteed minimum cost is presented, and with flexibility for multiple operating and casualty conditions. Second, interdependence between the electrical and cooling domains is modeled in detail, forming a new computational structure that could be extended to other domains as well. Third, a method for the integral design of minimum cost shipboard stored energy in consideration of casualty and operating conditions is shown. The overall methodology developed in this work can provide program managers assurance that design concepts all represent minimum cost and best value, thus reducing the trade space at an early stage when cost savings can be maximized in the acquisition program.
by Thomas Alan Trapp.
Ph. D.
41
McCord, Kent R. (Kent Richard). "Managing the integration problem in concurrent engineering." Thesis, Massachusetts Institute of Technology, 1993. http://hdl.handle.net/1721.1/37504.
Full text
42
Levin, Ari. "Modelling mechanical systems." Master's thesis, University of Cape Town, 1999. http://hdl.handle.net/11427/19420.
Full textAbstract:
Education should be one of the highest priorities of any country. The ability to pass on knowledge and understanding effectively is a sign of a good educational system. From an engineering perspective, better teaching tools allow for greater understanding by the students making them better engineers. Educational aids have been with us for a long time. Inventions from the abacus to the personal computer, have aided engineering students in faster understanding and application of their work. These aids are costly and sometimes become affordable only when outdated and redundant. A low-cost device that does not date would be the educationalist's ideal solution. To this end, a concept model of a conveyor sorting system was developed using Lego as the design medium. The model is a conveyor belt along which coloured blocks are sorted into bins by pneumatic cylinders. The model is controlled by a personal computer and the Lego interface box. The software is written in Visual Basic.
43
Reiter, Paige Lynette. "The Global Leadership Program's engineering design challenge as an example of a successful cross-university introduction to engineering and design." Thesis, Massachusetts Institute of Technology, 2016. http://hdl.handle.net/1721.1/105680.
Full textAbstract:
Thesis: S.B., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2016.Cataloged from PDF version of thesis.
Includes bibliographical references (pages 30-31).
The Global Leadership Program (GLP) is a chance for approximately 35 Singapore University of Technology and Design (SUTD) students to travel to the Massachusetts Institute of Technology (MIT) and participate in a cross-university cultural and educational exchange. The students have the opportunity to collaborate with and learn from MIT's own students and faculty during the program. The highlight of the summer is a nine-week design-build course, referred to as the Engineering Design Challenge, which teaches the fundamentals of engineering design and the necessary fabrication skills to execute those designs. The challenge requires small teams to design and build a single-person electric vehicle (EV). The first two years, the challenge was to make go-karts; since then, the scale has been increased to electric boats. The design challenge is presented as a real-world engineering exercise by intentionally being open-ended and primarily student-driven. It requires the students to practice both their technical skills as well as their interpersonal, professional, and leadership skills. This sort of allencompassing, immersive approach to education is based on principles found within the Project- Based Learning (PBL) and Conceive-Design-Implement-Operate (CDIO) pedagogical frameworks. Though it has only been around since 2013, the program has had a lasting impact on both the students that participated and their peers upon their return to Singapore. Elements of MIT's own student culture were shared with the participants and successfully transplanted back to SUTD at the program's end. This sort of cross-university educational and cultural exchange has exciting implications for expanding the global engineering educational network as the world becomes more and more connected.
by Paige Lynette Reiter.
S.B.
44
Mohammed, Dilveen Waheed. "Mechanical and electro-mechanical reliability of transparent oxide thin films for flexible electronics applications." Thesis, University of Birmingham, 2017. http://etheses.bham.ac.uk//id/eprint/7997/.
Full textAbstract:
Flexible electronic devices such as solar cells, touch panels and wearable displays have developed industrially and commercially in recent years because they are flexible and light weight at low cost. Since such devices constitute a brittle oxide layer applied to a polymer substrate, the cracking and/or film damage of the brittle inorganic coating when the device is under different mechanical and environmental loading during processing and service is one of the most important problems in the flexible electronic industry. This can lead to degradation and reduction in electrical functionality of the entire device; therefore, it is important to assess the behaviour of such layers under different mechanical deformation and environmental loads and to develop new mechanical testing for predicting reliability. This research focusses on the investigation of the reliability of two types of flexible components; indium gallium zinc oxide (IGZO), and Ag-alloy based indium tin oxide (ITO/Ag-alloy /ITO), that are typically used as a channel layer, and as an anode in thin film transistor and solar cell applications respectively. IGZO was deposited on both polyethylene terephthalate (PET) and polyethylene naphthalate (PEN) substrates for investigation including uniaxial tensile and buckling tests coupled with in situ confocal laser scanning microscopy. Ex situ scanning electron microscopy and atomic force microscopy were performed to investigate the cracking morphology of the IGZO films after testing. Furthermore, the electro-mechanical performance and corrosion resistance of ITO/Ag-alloy /ITO were investigated using in situ twisting tests, twisting fatigue, corrosion by aggressive salt environments, bending fatigue, bending fatigue-corrosion and long term bending under different temperature and humidity conditions.
45
Linder, Benjamin M. "Understanding estimation and its relation to engineering education." Thesis, Massachusetts Institute of Technology, 1999. http://hdl.handle.net/1721.1/31083.
Full textAbstract:
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1999.Includes bibliographical references (p. 86-87).
A wide variety of engineering activities benefit from the use of rough estimates of the type commonly referred to as back-of-the-envelope calculations. These include evaluating the feasibility of an idea, planning experiments, sizing components, and setting up and checking detailed analyses. The overall goals of this thesis were to understand how people make rough estimates for physical quantities and to understand how that activity relates to undergraduate engineering education. The specific objectives of this thesis were to describe the nature and extent of mechanical engineering students' estimation capabilities, to develop a framework describing estimation activity and to characterize the relationship between rough estimation activities and learning activities. The intent of these objectives was to develop conceptual knowledge useful for assessing and teaching rough estimation skills as well as for guiding estimation activity in practice. Students were found to have considerable difficulty making estimates for common engineering quantities, such as force and energy. Students were also found to have difficulty applying basic engineering concepts in rough estimation situations even at the senior level. In order to identify concepts that give students difficulty, a new assessment method based on students' ability to associate correct units with common engineering quantities was developed. The mediated action framework that was developed consists of three components: effective actions people take when they make estimates, mediating characteristics and the resulting limitations imposed on these actions, and compensation methods people use to circumvent these limitations. The primary focus of this thesis was on identifying the effective actions. A set of effective actions was identified that was sufficient to describe a large number of people's solutions to a variety of estimation problems. The relationship between rough estimation and engineering curricula was examined by comparing rough estimation activities in practice and learning activities in curricula. Rough estimation activities were found to be incongruent with typical undergraduate engineering curricula. The differences between these activities suggest ways in which curricula might be changed to improve students' estimation skills.
Benjamin M. Linder.
Ph.D.
46
Mroszczyk, Keri A. "A tissue engineering strategy for integrative cartilage repair." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/92188.
Full textAbstract:
Thesis: S.M., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2014.Cataloged from PDF version of thesis.
Includes bibliographical references (pages 56-64).
Tissue engineering for cartilage repair is a promising approach for improving the healing of articular defects, as biomaterials and growth factors can be supplied directly to a focal lesion. However, integrating neo-tissue with native cartilage to provide mechanical and biological continuity at the interface remains a challenge due to the limited regenerative capacity of the tissue. In an effort to improve integration, enzyme treatments were investigated as a means of functionally grafting engineered tissue to native tissue. Using an in vitro model of defect repair, this study develops a repair strategy that employs both a hydrogel (KLD) functionalized with HB-IGF-1 and an enzyme pre-treatment of the cartilage surrounding a defect to provide local delivery of the pro-anabolic factor and allow for functional integration of cartilage neo-tissue. Results indicate that the rate of proteoglycan synthesis was elevated in cartilage explants into which KLD pre-mixed with HB-IGF-1 had been cast; both the explants that had received the enzyme pre-treatment and those that were left untreated had a two-fold increase compared to the explants exposed to non-functionalized KLD. Similarly, GAG content was favorably elevated in the chondrocyte-seeded gels exposed to the growth factor. While GAG was depleted selectively within the inner annulus of the explants receiving the pre-treatment, no negative effect was observed on the rate of proteoglycan synthesis or GAG content compared to that in explants left untreated. Further, mechanical tests suggest that the combination of KLD functionalized with HB-IGF- 1 together with an enzyme pre-treatment is able to increase interfacial strength between engineered tissue and native matrix. Taken together, a repair strategy combining an enzyme pre-treatment of a defect with a peptide hydrogel functionalized with pro-anabolic HB-IGF-1, as developed in this study, is a promising approach for enhancing integration. Stimulating the surrounding tissue with the growth factor and allowing for functional integration of newly synthesized matrix promotes continuity at the interface between new and native tissue, ultimately improving the overall quality of repair.
by Keri A. Mroszczyk.
S.M.
47
Tsedev, Uyanga. "Engineering M13 bacteriophage platforms for cancer therapy applications." Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/103838.
Full textAbstract:
Thesis: S.M., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2015.Cataloged from PDF version of thesis.
Includes bibliographical references (pages 46-48).
Two novel schemes for engineering M13 bacteriophage for application in the diagnosis, imaging and treatment of human tumors are proposed. Firstly, by exploiting the uniquely malleable biology of the M13 filamentous phage, we have engineered filamentous phages of shorter lengths by constructing our own set of small viral ssDNA that are packaged by M13 capsid proteins. These 'inho' phages can be sized to ~50nm and above in length. The small phage retains the M13 major and minor coat proteins which have previously been manipulated to serve as tethers to carry various therapy and imaging agents and target specific cancer sites. Now with the ability to control the aspect ratio of these rigid, rod-like phages we can further improve on M13 based cancer detection by optimizing for phage blood circulation and tumor extravasation. Secondly, we have added to our cancer targeting M13 platform collection by cloning for chlorotoxin display on the tail p3 capsid protein of M13. Chlorotoxin can induce passage across blood-brain barrier, targets for cancer cells, and specifically internalizes to glioma cells. Expression of chlorotoxin on M13 will allow us to capitalize on its strong affinity for tumors of neuroectodermal origin and expand the M13 therapy and imaging platform to tumor masses in the brain.
by Uyanga Tsedev.
S.M.
48
Yung, Melody T. 1976. "Revamping EDICS : the Engineering-Design Instructional Computer System." Thesis, Massachusetts Institute of Technology, 2003. http://hdl.handle.net/1721.1/89931.
Full text
49
Hinton, Zoe Lynne. "Reverse-engineering a naturally-aspirated Lunenburg Foundry carburetor." Thesis, Massachusetts Institute of Technology, 2018. http://hdl.handle.net/1721.1/119954.
Full textAbstract:
Thesis: S.B., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2018.Cataloged from PDF version of thesis.
Includes bibliographical references (page 33).
The Lunenburg Foundry, based out of Nova Scotia, is a well-known manufacturer for early 20th century marine engines made famous by its Atlantic Marine Engine. This engine revolutionized the fishing industry along the Atlantic coast of Canada by creating a sort of "iron sail" for fisherman and sailors. The goal of this thesis is to reverse-engineer a naturally-aspirated Lunenburg Foundry carburetor from the Atlantic engine. The actual carburetor at MIT is one of few in existence, and has no accompanying patterns or drawings. The carburetor was disassembled and each part carefully measured by hand. A CAD assembly was developed of the entire carburetor to serve as an engineering database for future manufacturing and study.
by Zoe Lynne Hinton.
S.B.
50
Oki, Kristi Elena. "Multidisciplinarity and creativity of engineering and science students." Thesis, Massachusetts Institute of Technology, 2017. http://hdl.handle.net/1721.1/111706.
Full textAbstract:
Thesis: S.M., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2017.Cataloged from PDF version of thesis.
Includes bibliographical references (pages 57-61).
Engineering students must be prepared develop creative solutions to problems that fall at the intersection of multiple disciplines. In order to better understand the role of multidisciplinary learning and creativity within engineering education, this thesis explores the multidisciplinarity of expertise/interest and creativity of college and graduate-level engineering and science students. An online survey was designed to investigate the relationship between creativity and multidisciplinarity of students. Findings from the two creativity tests (Alternate uses and Consequences) revealed a positive correlation between quantity of ideas generated and novelty of ideas. As expected, level of expertise in the engineering and natural sciences disciplines overall was greater than expertise in other disciplines, but interest level was more spread out across disciplines. A substantial correlation between multidisciplinarity of expertise/ interest and creativity was not observed. However, findings based on subpopulations of the student sample suggest the possibility that multidisciplinarity and creativity may be correlated, but the nature of the relationship may differ depending on other demographic factors such as gender, student status (undergraduate vs. graduate), or current field (engineering vs. sciences).
by Kristi Elena Oki.
S.M.