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Arndt, Bruno Felipe. "MME-MDD : um método para manutenção e evolução de sistemas baseados no MDD." Universidade Federal de São Carlos, 2016. https://repositorio.ufscar.br/handle/ufscar/8503.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Model-Driven Development (MDD) is proposed to reduce the semantic gap between problem and solution/implementation domains. Some tools are used, and the code generator is commonly used in this context. These generators are often implemented using templates. A Reference Implementation (RI) favoring the development/ maintenance of software facilitates this implementation’s types. However, RI requires a code migration process which consists in artifacts’ synchronization, and it is responsible for 20% to 25% of the time spent on development. The literature has no describe automatic solutions, but the group that this reaserch was included has develop tools that automate this process and reduce the time spent on some tasks. But each task has a different performance in relation to time spent, so automation of some tasks can be disadvantageous. Few reports describe such tasks and which ones are capable of automatic code migration. The aim of this study is to investigate the maintain and evolution process to identify and describe the types of maintain and evolution tasks that are essentially. Based on this study, a method (MME-MDD) that drives the developer during that proccess to guide the developer during the realization of each task, with the aim to maximize the benefits of this approach. The MME-MDD was validated by a case study and a empirical study and the method showed effective in most of tasks. In addition, studies show that using the proposed method brought a gain in the quality of the source code.
O MDD (Model-Driven Development) tem como proposta a redução da distância semântica entre os domínios problema e solução/implementação. Para isso, são utilizadas algumas ferramentas, sendo o gerador de código comumente usado neste contexto. Os geradores de código são frequentemente implementados com a utilização de templates. Para facilitar este tipo de implementação, usualmente é empregado uma Implementação de Referência (IR), favorecendo a evolução/ manutenção do software. Contudo, a IR traz a necessidade do processo de migração de código, que consiste na sincronização entre o seu código-fonte e os templates, sendo que este é responsável por 20 a 25% do tempo gasto no desenvolvimento. Na literatura não há relatos de solução automatizada, mas o grupo no qual esta pesquisa se insere vem desenvolvendo ferramentas que automatizam este processo e reduzem o tempo aplicado em algumas tarefas testadas. Porém, cada tarefa tem um desempenho diferente em relação ao tempo gasto e, portanto, a automação de algumas tarefas pode ser desvantajosa. Existem poucos relatos na literatura descrevendo tais tarefas e quais são os passos necessários para realizá-las. O objetivo deste estudo foi a investigação do processo de manutenção e evolução de sistemas baseados em MDD com a finalidade de identificar e descrever os tipos de tarefas de manutenção e evolução. Com base nesse estudo, foi elaborado o método MMEMDD que conduz o desenvolvedor durante o processo de manutenção e evolução de sistemas, visando guiar o desenvolvedor durante a realização de cada um dos tipos de tarefas, com o intuito de maximizar os benefícios da utilização dessa abordagem. O método foi validado por meio de um estudo de caso e um estudo experimental, sendo que o método se mostrou efetivo em grande parte das tarefas testadas. Além disso, os estudos apontaram que a utilização do método proposto trouxe ganho na qualidade do código-fonte.
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Alfaris, Anas (Anas Faris). "Emergence through conflict : the Multi-Disciplinary Design System (MDDS)." Thesis, Massachusetts Institute of Technology, 2009. http://hdl.handle.net/1721.1/49718.
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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Architecture, 2009.Includes bibliographical references (p. 413-430).
This dissertation proposes a framework and a group of systematic methodologies to construct a computational Multi-Disciplinary Design System (MDDS) that can support the design of complex systems within a variety of domains. The way in which the resulting design system is constructed, and the capabilities it brings to bare, are totally different from the methods used in traditional sequential design. The MDDS embraces diverse areas of research that include design science, systems theory, artificial intelligence, design synthesis and generative algorithms, mathematical modeling and disciplinary analyses, optimization theory, data management and model integration, and experimental design among many others. There are five phases to generate the MDDS. These phases involve decomposition, formulation, modeling, integration, and exploration. These phases are not carried out in a sequential manner, but rather in a continuous move back and forth between the different phases. The process of building the MDDS begins with a top-down decomposition of a design concept. The design, seen as an object, is decomposed into its components and aspects, while the design, seen as a process, is decomposed into developmental levels and design activities. Then based on the process decomposition, the architecture of the MDDS is formulated into hierarchical levels each of which comprises a group of design cycles that include design modules at different degrees of abstraction. Based on the design object decomposition, the design activities which include synthesis, analysis, evaluation and optimization are modeled within the design modules.
(cont.) Subsequently through a bottom-up approach, the design modules are integrated into a data flow network. This network forms MDDS as an integrated system that acts as a holistic structured functional unit that explores the design space in search of satisfactory solutions. The MDDS emergent properties are not detectable through the properties and behaviors of its parts, and can only be enucleated through a holistic approach. The MDDS is an adaptable system that is continuously dependent on, and responsive to, the uncertainties of the design process. The evolving MDDS is thus characterized a multi-level, multi-module, multi-variable and multi-resolution system. Although the MDDS framework is intended to be domain-independent, several MDDS prototypes were developed within this dissertation to generate exploratory building designs.
by Anas Alfaris.
Ph.D.
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Kwan, Tony 1972. "Structural and functional analysis of the mouse Mdr3 P-glycoprotein." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=38069.
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Multidrug resistance in certain tumours in vivo and in cultured cells in vitro is caused by the overexpression of P-glycoprotein. Pgps are encoded by a small family of three genes in rodents (mdr1, mdr2, mdr3 ) and two in humans (MDR1, MDR2), and belong to the larger superfamily of ABC transporters, characterized by their ability to transport various substrates at the expense of ATP. Pgps are comprised of 12 transmembrane (TM) domains, some of which are involved in the binding of these drugs, and two intracellular nucleotide-binding (NB) domains that catalyze ATP hydrolysis. Communication occurs between these two regions as drug binding can significantly activate the ATPase activity, and the signalling is thought to occur through the highly conserved intracellular (IC) loops linking the individual TM domains. Using a random mutagenesis approach, mutations were identified in IC1 affecting both substrate specificity and drug-stimulated ATPase activity of Pgp. The finding that mutations in IC1 can modulate the activities of two separate and distinct regions supports the proposed role for the IC loops. Purification of Pgp mutants to a high degree allowed for the further biochemical characterization of selected mutants in IC1. The findings support a role for IC1 in signalling between the two regions: (1) from the TM domains to the NB sites to activate ATPase activity, and (2) in the opposite direction to effect drug release. The analysis of mutations in TM11 provides more support that this helix is involved in protein-substrate interactions and forms part of the drug-binding site. The formation and maintenance of an active drug-binding site through the proper organization and orientation of TM helices are critical to the function of Pgp. Despite the large body of functional data through the characterization of the many naturally occurring and genetically engineered mutants of Pgp, high-resolution structural information of the drug binding site and the overall structur
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Spencer, Erick. "Sequence and tissue expression of the ABCB4 (MDR3) gene in the canine." Online access for everyone, 2008. http://www.dissertations.wsu.edu/Thesis/Summer2008/e_spencer_072308.pdf.
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Basso, F?bio Paulo. "Features-oriented model-driven architecture : uma abordagem para MDD." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2006. http://tede2.pucrs.br/tede2/handle/tede/5213.
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Previous issue date: 2006-03-31O desenvolvimento de software dirigido por modelos, com a MDA, requer o refinamento de modelos de sistemas, inicialmente especificados em alto n?vel e sem caracter?sticas de plataformas, em modelos dependentes de plataformas. A Model Driven Architecture (MDA) apresenta uma t?cnica de modelagem voltada para arquiteturas, em que ? necess?rio aplicar mapeamentos e transforma??es em modelos de sistemas para plataformas. Esse trabalho apresenta a abordagem FOMDA (Features-Oriented Model-Driven Architecture), que permite a desenvolvedores especificar modelos e gerenciar transforma??es adotando a t?cnica MDA. A abordagem FOMDA combina Modelos de Features e MDA em um ambiente onde desenvolvedores s?o habilitados para representar caracter?sticas atrav?s de features, mapeando-as para transforma??es que geram a aplica??o final. Este trabalho tamb?m apresenta um estudo de caso, que utiliza a abordagem FOMDA para auxiliar no desenvolvimento de um sistema de tempo real embarcado
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Basso, Fábio Paulo. "Features-oriented model-driven architecture: uma abordagem para MDD." Pontifícia Universidade Católica do Rio Grande do Sul, 2006. http://hdl.handle.net/10923/1520.
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Previous issue date: 2006The model driven software development with MDA requires the transformation of system models, initially specified in high-level and platform independent, into platform dependent models. The Model Driven Architecture (MDA) presents an architectural guided modeling technique, using mappings and transformations that must be applied in the system models according system platforms. This work presents the FOMDA (Features-Oriented Model-Driven Architecture) approach, to help developers specifying models and managing transformations using the MDA technique. The FOMDA approach combines Features Model and MDA in an environment where developers can represent system characteristics with features and map them to transformation code that is responsible to generate the final application. This work also presents a case study using FOMDA to assist the development on an embedded real-time system.
O desenvolvimento de software dirigido por modelos, com a MDA, requer o refinamento de modelos de sistemas, inicialmente especificados em alto nível e sem características de plataformas, em modelos dependentes de plataformas. A Model Driven Architecture (MDA) apresenta uma técnica de modelagem voltada para arquiteturas, em que é necessário aplicar mapeamentos e transformações em modelos de sistemas para plataformas. Esse trabalho apresenta a abordagem FOMDA (Features-Oriented Model-Driven Architecture), que permite a desenvolvedores especificar modelos e gerenciar transformações adotando a técnica MDA. A abordagem FOMDA combina Modelos de Features e MDA em um ambiente onde desenvolvedores são habilitados para representar características através de features, mapeando-as para transformações que geram a aplicação final. Este trabalho também apresenta um estudo de caso, que utiliza a abordagem FOMDA para auxiliar no desenvolvimento de um sistema de tempo real embarcado.
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Lepage, Pierre 1962. "Activation of the mouse mdr3 gene in multidrug resistant derivatives of the lymphoid tumor P388." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=28822.
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In independently derived drug resistant sublines of the mouse lymphoid tumor P388, multidrug resistance (MDR) is associated with the exclusive overexpression of the mdr3 gene, which occurs either from a single copy gene (P388/VGR-10) or after gene amplification (P388/ADM-2). The mechanism underlying mdr3 overexpression in these cells was investigated. Nucleotide sequence analysis revealed the presence of several putative cis-regulatory elements in the genomic region overlapping the transcription start site of mdr3. However, the 5$ sp prime$ end of mdr3 mRNAs was shown to be altered in the MDR derivatives of P388, indicating that the normal start site is not used in these cells. In the two cell lines, these alterations are associated with a genomic rearrangement in the 5$ sp prime$ region of the gene caused by the insertion of retroviral sequences. In P388/ADM-2, the integration of an intracistemal A particle within an L1Md repetitive element immediately upstream of mdr3 results in the activation of the gene. In P388/VCR-10 cells, transcriptional activation of mdr3 is caused by the integration of an intact mouse mammary tumor virus (MMTV) within intron I in the opposite transcriptional (antisense) orientation compared to that of the gene. This integration results in the production of MMTV/mdr3 fusion transcripts from a cryptic promoter in the 5$ sp prime$ long terminal repeat (LTR) of the provirus. In transient transfection experiments, it was shown that the antisense 5$ sp prime$ LTR alone only weakly activates the reporter gene luciferase. However, addition of mdr3-derived sequences from intron I downstream of the 5$ sp prime$ LTR strongly activates the expression of luciferase, suggesting the presence of an activator/enhancer element in this region. These results and subsequent identification of independent genomic rearrangements in the 5$ sp prime$ region of mdr3 in additional MDR P388 derivatives analyzed in this study suggest a mechanism of gene activation i
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De, Vulpillieres Quitterie. "Rôle de l'extrémité C-terminale d'ABCB4/MDR3 : Interaction avec la protéine à domaines PDZ EBP50." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066038.
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ABCB4/MDR3 est le transporteur canaliculaire de la phosphatidylcholine. Il est exprimé à la membrane canaliculaire des hépatocytes et est essentiel à la sécrétion biliaire. Un défaut d’ABCB4 entraîne des pathologies hépatobiliaires, dont la PFIC3 (cholestase intrahépatique familiale progressive de type 3), caractérisée par une cholestase précoce qui progresse vers la cirrhose et l’insuffisance hépatique avant l’âge adulte. Dans la majorité des cas, la seule thérapie efficace est la transplantation hépatique. Cette thèse s’intéresse aux rôles de l’extrémité C-terminale dans la régulation de la stabilité et l’expression de ce transporteur au canalicule biliaire. Nous avons délété le motif Q-N-L de cette extrémité et montré que cette délétion affecte la stabilité d’ABCB4/MDR3 en augmentant son endocytose. Son interaction avec des protéines à domaines PDZ est alors étudiée. Nous avons montré une interaction par le motif Q-N-L avec la protéine à domaines PDZ, EBP50. Cette interaction est nécessaire pour l’expression canaliculaire et la stabilité du transporteurABCB4 is a phosphatidylcholine translocator specifically expressed at the bile canalicular membrane of hepatocytes. Mutations of the ABCB4 gene cause progressive familial intrahepatic cholestasis type 3 (PFIC3), a rare genetic disease characterized by early onset of cholestasis and evolution to cirrhosis and liver failure before adulthood. Little is known regarding the molecular mechanisms which control the canalicular expression and membrane stabilization of ABCB4 in hepatocytes. The aim of this work was to study the role of the C-terminal domain of ABCB4 for its expression and stability. potential interaction with EBP50, a PDZ protein highly expressed in hepatocytes. The experimental approach consisted in the deletion of the QNL motif at the C-terminus of ABCB4. The truncation of the QNL motif leds to a reduction of ABCB4 stability by increasing its endocytosis. ABCB4 co-precipitated with EBP50, an interaction that required the QNL motif. This interaction plays a critical role in the canalicular expression and stabilization of ABCB4
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Kluth, Marianne [Verfasser], Lutz [Akademischer Betreuer] Schmitt, and Anselmino Verena [Akademischer Betreuer] Keitel-. "Molekulare in vitro Analyse des humanen ABC Transporters MDR3 / Marianne Kluth. Gutachter: Verena Keitel- Anselmino. Betreuer: Lutz Schmitt." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2015. http://d-nb.info/1066815526/34.
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Prescher, Martin [Verfasser], Lutz [Gutachter] Schmitt, and Anselmino Verena [Gutachter] Keitel-. "In vitro characterization of the human ABC transporter MDR3/ABCB4 / Martin Prescher ; Gutachter: Lutz Schmitt, Verena Keitel- Anselmino." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2021. http://d-nb.info/1227038631/34.
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Koopowitz, Sheri. "Neuroimaging and neurocognitive assessment of PTSD and MDD in a South African community setting." Doctoral thesis, Faculty of Health Sciences, 2019. http://hdl.handle.net/11427/30409.
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Background: There is growing evidence of abnormalities in neurocognition, neuroanatomy, and functional connectivity in posttraumatic stress disorder (PTSD) and major depressive disorder (MDD). However, there has been less work on individuals who suffer with comorbid PTSD and MDD. It is important to investigate the neurobiology of this overlap because of its prevalence, its associated morbidity, and the hope that it may shed more light on the mechanisms involved in each disorder, including the role of the prefrontal regions. This dissertation tests the hypothesis that women with PTSD and MDD display distinct patterns of neurocognitive impairment and associated brain dysfunction, relative to healthy controls, and these effects will be amplified in patients with both disorders. Methods: This dissertation was undertaken within the Drakenstein Child Health Study, a study exploring child health determinants in mother-infant dyads from the Drakenstein district, Western Cape. Mothers (between 18 and 50 years) were recruited and divided into 4 groups: PTSD, MDD, PTSD with MDD, and healthy controls. Participants were assessed using the computerised NIH Toolbox, and paper and pencil neurocognitive tests. Domains assessed included memory, learning, and processing speed, and with particular focus on executive function and attention domains. Participants underwent resting-state functional imaging as well as structural brain imaging. Functional connectivity within and between cognitive control networks (salience network, dorsal attention network, and frontoparietal networks) and a default mode network were compared across the 4 groups. Neuroanatomical indices (cortical thickness, volume, and surface area) of 10 frontal cortical regions from the Desikan-Killiany atlas in Freesurfer 6 were analysed across the 4 groups. Results: All three clinical groups demonstrated no group differences on measures of attention and executive function, diagnoses of PTSD and MDD were associated with more intrusive thoughts and delayed recall impairment, respectively. However, neurocognitive findings indicate that PTSD with comorbid MDD is not associated with greater neurocognitive dysfunction relative to mono-diagnostic groups. Abnormal resting-state connectivity was observed for the MDD group in the default mode network, and for both comorbid and MDD patient groups within frontoparietal networks. Abnormal salience network connectivity for the comorbid group was observed when examining performance on the Pattern Comparison Processing Speed test. No between-network connectivity group differences were observed. Surface area and volume reductions of prefrontal regions were evident for PTSD and MDD, however, no volumetric and surface area differences were observed for the comorbid group. Conclusion: In this sample of mothers from a low-middle income region, distinct patterns of neurocognitive dysfunction and impairment in PTSD, MDD, and PTSD with MDD were observed. However, contrary to hypotheses, comorbidity is not associated with greater dysfunction and impairment and the associations of PTSD and comorbid MDD are not amplified in this sample. These findings have implications for the development of treatment plans for patients diagnosed with PTSD, MDD, and PTSD with comorbid MDD, so that interventions are tailored in a way that is responsive to differences between these groups in the presentation of neurocognitive profile, brain function, and structure.
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Zeng, Yanni. "The identification of risk factors for major depressive disorder." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28702.
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For complex traits, population genetic studies ask: to what extent do genetic variation and environmental variation influence, determine and predict phenotypic variation? More specifically, researchers ask two questions. First, how much of the phenotypic variation is genetic in origin? Second, if the genetic component of a trait has been ascertained, then by what mechanisms do the causal variants contribute to the genetic variation that impacts on the phenotype? Previous studies have indicated a polygenic structure for many complex traits, which means that the genetic variation in those traits is the result of the cumulative effect from hundreds or even thousands of genetic variants. To further decipher the polygenic genetic architecture of a complex trait, genetic studies aim to identify the number, the location in the genome, and the distribution of the effect sizes of causal variants, as well as their individual and interacting effects. Linkage analysis and genome-wide association studies (GWAS), either based on single variants or sets of variants categorized by functional annotations, can be applied to map the potentially causal variants in the genome. The identification of disease-associated loci, however, is only the starting point in identifying causal variants. Causal variants are usually difficult to distinguish from the large number of variants in linkage disequilibrium (LD) within the associated loci, and may be in incomplete LD with genotyped variants. Computational prediction integrated with multi-level ‘Omic’ data will help the prioritization of candidate causal variants, which then become important targets for experimental validation (Chapter 1). Major depressive disorder (MDD) is a complex trait, contributes the second most important burden to global disease. Both genetic and environmental components have been suggested for this disorder in previous studies, although a clear partitioning of the contribution of each component and the identification of major contributing components is yet to be achieved. In efforts to map causal genetic variants, genome-wide association studies of MDD have identified few significant associations so far. The polygenic architecture combined with the widespread clinical and genetic heterogeneity of MDD between populations may impede the identification of causal variants (Chapter 2). In this thesis, I will present three studies; the first study estimated the proportions of the phenotypic variation that are genetic or familial environmental in origin in two depression definitions(chapter 3), followed by two studies where distinct (non- GWAS) methods were used to identify candidate causal genetic variants for MDD (chapter 4,5). In detail, in chapter 3, a variance component analysis was applied to GS:SFHS (Generation Scotland: Scottish Family Health Study) to investigate the relative genetic and environmental contributions to diagnosed major depressive disorder (MDD) and self-declared depression (SDD). Models for MDD and SDD that simultaneously included genetic and environmental effects suggested that narrow-sense heritability could be inflated by the environments shared by nuclear family members. The most parsimonious models selected for both MDD and SDD included SNP and pedigree-associated genetic effects and the effect of the common environment of couples. In chapter 4, I integrated pathway analysis and multi-level regional heritability analyses in a pipeline designed to identify MDD-associated pathways. The pipeline was applied to two independent GWAS studies (GS:SFHS and PGC1-MDD). The NETRIN1 signalling pathway showed the most consistent association with MDD across the two samples. Polygenic risk scores (PRSs) from this pathway showed predictive accuracy better than whole-genome PRSs when using AUC statistics, logistic regression and the linear mixed model. In chapter 5, genome-wide Haplotype-block-based regional heritability mapping (HRHM) was applied to identify haplotype blocks significantly contributing to MDD. A haplotype block across a 24kb region within the TOX2 gene reached genotype-wide significance in GS:SFHS. Single-SNP and haplotype based association tests were used to localize the association signal within the region identified by HRHM, and demonstrated that five out of nine genotyped SNPs and two haplotypes were significantly associated with MDD. The results were replicated in the UK-Ireland group in PGC2-MDD. The brain expression of TOX2 and brain-specific LncRNA RP1-269M15.3 were also significantly regulated by MDD-associated SNPs within the identified haplotype block. The three studies highlight the value of the application of multiple population genetics and bioinformatics methods to multiple family-based and population-based cohorts in identification of risk factors for MDD.
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Marinho, ?berton da Silva. "Um modelo conceitual baseado em MDD e padr?es para evolu??o de sistemas OA." Universidade Federal do Rio Grande do Norte, 2010. http://repositorio.ufrn.br:8080/jspui/handle/123456789/18039.
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Previous issue date: 2010-08-02Aspect-Oriented Software Development (AOSD) is a technique that complements the Object- Oriented Software Development (OOSD) modularizing several concepts that OOSD approaches do not modularize appropriately. However, the current state-of-the art on AOSD suffers with software evolution, mainly because aspect definition can stop to work correctly when base elements evolve. A promising approach to deal with that problem is the definition of model-based pointcuts, where pointcuts are defined based on a conceptual model. That strategy makes pointcut less prone to software evolution than model-base elements. Based on that strategy, this work defines a conceptual model at high abstraction level where we can specify software patterns and architectures that through Model Driven Development techniques they can be instantiated and composed in architecture description language that allows aspect modeling at architecture level. Our MDD approach allows propagate concepts in architecture level to another abstraction levels (design level, for example) through MDA transformation rules. Also, this work shows a plug-in implemented to Eclipse platform called AOADLwithCM. That plug-in was created to support our development process. The AOADLwithCM plug-in was used to describe a case study based on MobileMedia System. MobileMedia case study shows step-by-step how the Conceptual Model approach could minimize Pointcut Fragile Problems, due to software evolution. MobileMedia case study was used as input to analyses evolutions on software according to software metrics proposed by KHATCHADOURIAN, GREENWOOD and RASHID. Also, we analyze how evolution in base model could affect maintenance on aspectual model with and without Conceptual Model approaches
O Desenvolvimento de Software Orientado a Aspectos (DSOA) ? uma t?cnica que complementa o Desenvolvimento de Software Orientado a Objetos (DSOO) modularizando diversos conceitos que as abordagens para suporte ao DSOO n?o conseguiam modularizar adequadamente. No entanto, o estado da arte atual do DSOA sofre com a evolu??o de software, principalmente porque as defini??es de aspectos podem deixar de funcionar corretamente quando elementos do Modelo Base evoluem. Uma abordagem promissora para tratar este problema ? a defini??o de pontos de corte (pointcuts) baseados em modelos (model based-pointcuts), onde pontos de corte s?o definidos em termos de elementos de um Modelo Conceitual que s?o menos suscept?veis a evolu??o que elementos do Modelo Base. Com base nessa estrat?gia, este trabalho define um Modelo Conceitual em um alto n?vel de abstra??o onde se podem definir padr?es de software e de arquiteturas que atrav?s de t?cnicas de Desenvolvimento Dirigido a Modelos (Model Driven Development -MDD) podem ser instanciados e compostos em linguagens de descri??o arquitetural que suportem a modelagem de aspectos em n?vel de arquitetura. A abordagem MDD empregada permite ainda a propaga??o de conceitos descritos no Modelo Conceitual para outros n?veis de abstra??es como o de projeto com o uso de regras de transforma??o MDA (Model Driven Architecture). Este trabalho tamb?m mostra o plug-in para a plataforma Eclipse chamado de AOADLwithCM que foi implementado para dar suporte ao processo de desenvolvimento abordado. Esse plug-in foi utilizado para implementar um estudo de caso baseado no Sistema MobileMedia. Tal estudo de caso ilustra passo-a-passo a t?cnica que utiliza um Modelo Conceitual no DSOA para minimizar problemas de evolu??o (mais especificamente a Fragilidade de Pontos de Corte). O MobileMedia tamb?m foi usado como fonte para an?lise da abordagem sob m?tricas de software propostas por KHATCHADOURIAN, GREENWOOD e RASHID, e sob a perspectiva de manutenabilidade de software com e sem o Modelo Conceitual
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Aouinti, Mahmoud. "La gestion de la marque par les PME productrices des MDD : cas des fromageries québécoises." Thèse, Université du Québec à Trois-Rivières, 2009. http://depot-e.uqtr.ca/1566/1/030132835.pdf.
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Johnston, Divina T. Johnston. "A Phenomenological Study of Mal de Debarquement Syndrome." Antioch University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=antioch1495818569777854.
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Waldemarin, Ricardo Cacheta. "Suporte ao desenvolvimento e à integração de ontologias no domínio biomédico." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/95/95131/tde-18112015-100645/.
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O surgimento e o uso crescente de novas tecnologias têm levado à produção e armazenamento de grandes volumes de dados biomédicos. Tais dados são provenientes de diferentes técnicas, armazenados em formatos de representação diversos e utilizados por diferentes ferramentas. Esta heterogeneidade representa um empecilho ao maior uso desses dados em abordagens integrativas de pesquisa como, por exemplo, a biologia sistêmica. Neste cenário, artefatos de modelagem conceitual, tais como ontologias, têm sido utilizados para organizar e integrar dados heterogêneos de uma forma coerente. A OBO Foundry representa, atualmente, o maior esforço no desenvolvimento de ontologias biomédicas de forma colaborativa. Dentre as ontologias desenvolvidas pela OBO Foundry, destaca-se Ontologia de Relacionamentos (RO-OBO). A RO-OBO provê definições formais para um conjunto de relacionamentos de propósito geral utilizados nas ontologias biomédicas e busca promover a criação de ontologias mais corretas e integráveis. Um perfil UML foi proposto para representar formalmente o conjunto de conceitos e relacionamentos existentes na RO-OBO. Este perfil permite desenvolver modelos UML utilizando os conceitos presentes nesta ontologia, bem como torna possível o desenvolvimento de suporte à validação sintática dos modelos criados em relação a um conjunto de restrições formalmente definidas. Adicionalmente, percebe-se na literatura que o suporte à integração de modelos UML e ontologias OBO, em particular as ontologias representadas na linguagem OBO File Format, é limitado. Neste sentido, este trabalho teve como objetivo geral investigar o suporte ao desenvolvimento de ontologias biomédicas na linguagem UML. De forma específica, investigou-se o desenvolvimento de um editor gráfico, chamado OBO-RO Editor, para o suporte à construção de ontologias utilizando o perfil UML proposto, bem como a integração de ontologias desenvolvidas utilizando UML e ontologias desenvolvidas na linguagem OBO File Format. De forma a atingir nossos objetivos, uma arquitetura de referência foi definida e um processo de desenvolvimento orientado a modelos foi utilizado. A arquitetura definida é composta por uma série de artefatos inter-relacionados os quais são transformados (semi) automaticamente em código de aplicação, possibilitando a obtenção de ciclos de desenvolvimento mais rápidos e confiáveis. O OBO-RO Editor disponibiliza um conjunto de elementos gráficos de modelagem definidos a partir do perfil UML proposto, bem como provê mecanismos para a validação sintática (semi) automática de uma ontologia desenvolvida segundo as restrições definidas neste perfil. Adicionalmente, o OBO-RO Editor também provê suporte à integração de modelos UML a outras ontologias da OBO Foundry, permitindo o reuso e o desenvolvimento menos propenso a erros de ontologias no domínio biomédico.The development and increasing use of new technologies has resulted in the production and storage of a huge amount of biomedical data. These data are produced using different techniques, stored in different formats and consumed by different (software) tools. This heterogeneity hinders effective data usage in integrative research approaches, including systems biology. In this scenario, conceptual modeling artifacts, such as ontologies, have been used to organize and integrate heterogeneous data in a coherent manner. Nowadays, the OBO Foundry represents the most important effort for the collaborative development of ontologies in the biomedical domain. The OBO Relation Ontology (OBO-RO) can be considered one of the most relevant ontologies in the domain. This ontology provides formal definitions for a number of general purpose relationships used in biomedical ontologies, thus facilitating the integration of existing ontologies and the development of new ontologies in the domain. An UML profile has been proposed to formally define the different types of concepts and relationships provided by the OBO-RO. This profile enables the creation of UML models using such concepts and allows the development of support for the automatic validation of these models based on formal constraints. Additionally, the support for the integration between UML models and OBO ontologies, particularly ontologies represented using the OBO File Format, is limited. In this sense, this project aimed at investigating the support for the development of biomedical ontologies using UML. In particular, we investigated the development of a graphical editor, named OBO-RO Editor, to support ontology development using the proposed UML profile. Additionally, we also investigated the integration of ontologies developed using UML and ontologies developed using the OBO File Format. In order to achieve our goals, we have defined a reference architecture and a model-driven development process. The reference architecture consists of a number of related artifacts that are transformed to application code (semi) automatically. Such characteristic allowed us to obtain faster and more reliable development cycles. The OBO-RO Editor provides a number of graphical elements defined in the proposed UML profile for the modeling of biomedical ontologies and support the (semi) automatic syntactic validation of such ontologies against the contraints defined in the profile. Additionally, OBO-RO Editor also provides support for the integration of developed UML models and other OBO ontologies, allowing the reuse and the accurate development of biomedical ontologies.
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Medeiros, Ana Luisa Ferreira de. "MARISA-MDD: uma abordagem para transforma??es entre modelos orientados a aspectos: dos requisitos ao projeto detalhado." Universidade Federal do Rio Grande do Norte, 2008. http://repositorio.ufrn.br:8080/jspui/handle/123456789/17979.
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Previous issue date: 2008-06-09Aspect Oriented approaches associated to different activities of the software development process are, in general, independent and their models and artifacts are not aligned and inserted in a coherent process. In the model driven development, the various models and the correspondence between them are rigorously specified. With the integration of aspect oriented software development (DSOA) and model driven development (MDD) it is possible to automatically propagate models from one activity to another, avoiding the loss of information and important decisions established in each activity. This work presents MARISA-MDD, a strategy based on models that integrate aspect-oriented requirements, architecture and detailed design, using the languages AOV-graph, AspectualACME and aSideML, respectively. MARISA-MDD defines, for each activity, representative models (and corresponding metamodels) and a number of transformations between the models of each language. These transformations have been specified and implemented in ATL (Atlas Definition Language), in the Eclipse environment. MARISA-MDD allows the automatic propagation between AOV-graph, AspectualACME, and aSideML models. To validate the proposed approach two case studies, the Health Watcher and the Mobile Media have been used in the MARISA-MDD environment for the automatic generation of AspectualACME and aSideML models, from the AOV-graph model
As abordagens orientadas a aspectos relacionadas a diferentes atividades do processo de desenvolvimento de software s?o, em geral, independentes e os seus modelos e artefatos n?o est?o alinhados ou inseridos em um processo coerente. No desenvolvimento orientado a, modelos, os diversos modelos e a correspond?ncia entre eles s?o especificados com rigor. Com a integra??o do desenvolvimento orientado a aspectos (DSOA) e o desenvolvimento baseado em modelos (MDD) pode-se automaticamente propagar modelos de uma atividade para outra atividade, evitando a perda de informa??es e de decis?es importantes estabelecidas em cada atividade. Este trabalho apresenta MARISA-MDD, uma estrat?gia baseada em modelos que integra as atividades de requisitos, arquitetura e projeto detalhado orientado a aspectos, usando as linguagens AOV-graph, AspectualACME e aSideML, respectivamente. MARISA-MDD define, para cada atividade, modelos representativos (e metamodelos correspondentes) e um conjunto de transforma??es entre os modelos de cada linguagem. Tais transforma??es foram especificadas e implementadas em ATL (Atlas Definition Language), no ambiente Eclipse. MARISA-MDD permite a propaga??o autom?tica entre modelos AOV-graph, AspectualACME e aSideML. Para validar a abordagem proposta dois estudos de caso, o Health Watcher e o Mobile Media foram usados no ambienteMARISA-MDD para gera??o autom?tica dos modelos AspectualACME e aSideML, a partir do modelo AOV-graph
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Sgueglia, Umberto. "Predicting Novel Drug-drug Interactions based on structured knowledge in combination with text mining approaches." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2018. http://amslaurea.unibo.it/15494/.
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Molto spesso le persone in cura presso gli ospedali possono soffrire di strani effetti collaterali di cui non si conosce minimamente l’origine. In alcuni casi questo può derivare da una sbagliata prescrizione di medicinali al paziente.
Ben noto nella medicina sono gli effetti che una medicina può causare somministrata con un altra allo stesso tempo. Quello che non si conosce, è il risultato di una somministrazione multipla, ovvero quando più medicinali
vengono somministrati contemporaneamente.
Il problema che vogliamo affrontare in questa tesi è quello di capire se sia
possibile usare le informazioni che abbiamo sulle interazioni tra due medicine,
e cercare di costruire un calssificatore in grado di predirre interazioni tra più
medicine nel caso in cui queste possano portare ad effetti collaterali.
Alla base di questo procedimento si trovano le informazioni che chiamer-
emo pair information, ovvero quelle riguardanti due medicine. Date queste
proveremo ad estendere il concetto ad interazioni multiple di medicine.
Come punto di partenza per la ricerca è stata scelta una lista di 77
medicine candidate, le più prescritte durante lo scorso anno in Germania.
Come vedremo successivamente sono state utilizzate fonti di dati strut-
turati e non per cercare di dare maggiore significato di quello che già posse-
diamo per quanto riguarda le pair interaction.
Come vedremo dalla valutazione, la combinazione di elementi derivanti
dal text mining e dati fortemente non strutturati, con elementi invece strut-
turati e verificati può portare risultati davvero interessanti.
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Shahrour, Ghada. "COGNITIVE AND EMOTIONAL EMPATHY IN ADOLESCENTS WITH ADHD: ARE COMORBIDITIES, GENDER, AND PARENTAL ACCEPTANCE-REJECTION IMPORTANT FACTORS?" Kent State University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=kent1510587554078524.
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SARMENTO, Jones Cavalcanti. "Uma abordagem MDD para prover integridade topológica e de rede em projeto conceitual de banco de dados espaciais." Universidade Federal de Pernambuco, 2015. https://repositorio.ufpe.br/handle/123456789/17235.
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FACEPE
Model-Driven Development (MDD) é um paradigma que usa modelos como o principal artefato no processo de desenvolvimento de sistemas. Isto é, neste paradigma, modelos não são apenas artefatos de documentação, pois devem corresponder a códigos executáveis. Em projetos de Banco de Dados Espaciais (BDE), existem várias linguagens de modelagens (e.g., OMT-G, MADS, GeoProfile e UML-GeoFrame), as quais permitem representar características espaciais (e.g., Múltiplas Representações e Relacionamento Espacial) por meio de uma ferramenta do tipo Computer-Aided Software Engineering (CASE). Embora essas linguagens sejam bem exploradas e difundidas na literatura, constatou-se que estas têm deficiências para modelar e implementar integridade espacial a partir de entidades com múltiplas representações. Assim, de modo a avançar o estado da arte sobre projeto de BDE, este trabalho faz uma análise dos principais trabalhos relacionados, e, de modo a contribuir para superar as deficiências encontradas, propõe uma extensão espacial para a linguagem de modelagem Enhanced Entity Relationship (EER). Essa extensão é implementada na ferramenta EERCASE e avalidada por meio de uma análise comparativa com os principais trabalhos relacionados, evidenciando seus pontos fortes e fracos.
Model-Driven Development (MDD) is a paradigm that uses models as the primary artifact in the systems development process. That is, in this paradigm, models are not only documentation artifacts, since these should be the executable code. In Spatial Databases projects (SDB), there are several modeling languages (e.g., OMT-G, MADS, GeoProfile and UML-GeoFrame), which allow to represent spatial characteristics (e.g., Multiple Representations and Spatial Relationship) by means of a tool type Computer-Aided Software Engineering (CASE). Although these languages are better exploited and widespread in the literature, it was found that they have deficiencies in modeling and implement spatial integrity from entities with multiple representations. Thus, in order to advance the state of the art in SDB project, this paper analyzes the main works related and, in order to contribute to overcome the deficiencies, proposes a spatial extension for modeling language Enhanced Entity Relationship (EER). This extension is implemented in tool EERCASE and evaluated through a comparison with the main work related, highlighting their strengths and weaknesses.
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Sousa, Lidiane Oliveira dos Santos. "Reqsys-MDD: uma ferramenta para mapeamento entre modelos de features e requisitos em linhas de produto de software." Universidade Federal do Rio Grande do Norte, 2012. http://repositorio.ufrn.br:8080/jspui/handle/123456789/18055.
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Previous issue date: 2012-05-23Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior
The approach Software Product Line (SPL) has become very promising these days, since it allows the production of customized systems on large scale through product families. For the modeling of these families the Features Model is being widely used, however, it is a model that has low level of detail and not may be sufficient to guide the development team of LPS. Thus, it is recommended add the Features Model to other models representing the system from other perspectives. The goals model PL-AOVgraph can assume this role complementary to the Features Model, since it has a to context oriented language of LPS's, which allows the requirements modeling in detail and identification of crosscutting concerns that may arise as result of variability. In order to insert PL-AOVgraph in development of LPS's, this paper proposes a bi-directional mapping between PL-AOVgraph and Features Model, which will be automated by tool ReqSys-MDD. This tool uses the approach of Model-Driven Development (MDD), which allows the construction of systems from high level models through successive transformations. This enables the integration of ReqSys-MDD with other tools MDD that use their output models as input to other transformations. So it is possible keep consistency among the models involved, avoiding loss of informations on transitions between stages of development
A abordagem de Linha de Produto de Software (LPS) tem se tornado bastante promissora nos dias de hoje, uma vez que permite a produ??o de sistemas customizados em larga escala, atrav?s de fam?lias de produtos. Para a modelagem destas fam?lias o Modelo de Features tem sido muito utilizado, no entanto, se trata de um modelo que apresenta baixo n?vel de detalhamento, podendo n?o ser suficiente para orientar a equipe de desenvolvimento da LPS. Dessa forma, ? recomend?vel agregar o Modelo de Features a outros modelos que representem o sistema sob outras perspectivas. O Modelo de Metas PL-AOVgraph pode assumir esta fun??o complementar ao Modelo de Features, uma vez que possui uma linguagem voltada para o contexto das LPS s, que permite a modelagem de requisitos de forma detalhada e a identifica??o de caracter?sticas transversais, que podem surgir em decorr?ncia da variabilidade. Com o objetivo de inserir PL-AOVgraph no processo de desenvolvimento das LPS s, este trabalho prop?e um mapeamento bi-direcional entre PLAOVgraph e Modelo de Features, que ser? automatizado pela ferramenta ReqSys-MDD. Esta ferramenta utiliza a abordagem de Desenvolvimento Orientado a Modelos (Model-Driven Development MDD), que permite a constru??o de sistemas a partir de modelos de alto n?vel, atrav?s de transforma??es sucessivas. Isto possibilita a integra??o de ReqSys-MDD com outras ferramentas MDD que utilizem seus modelos de sa?da como entrada para outras transforma??es. Assim, ? poss?vel manter a consist?ncia entre os modelos envolvidos, evitando a perda de informa??es nas transi??es entre as etapas de desenvolvimento
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Bahha, Nawfal. "La satisfaction de la relation fournisseur de marque de distributeur (MDD) - distributeur : explication par le prisme de la proximité." Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM2011.
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A travers le cas des fournisseurs de Marques de Distributeurs (MDD) en agro-alimentaire, cette thèse vise à montrer que la satisfaction du fournisseur peut être expliquée par la proximité entre ce dernier et son distributeur. En adoptant une posture épistémologique positiviste et une démarche hypothético-déductive, nous avons réalisé une revue de littérature qui a permis d’élaborer un modèle conceptuel. Celui-ci postule que la proximité, déclinée en quatre dimensions-proximité relationnelle, proximité identitaire, proximité de processus et proximité géographique, est un antécédent de la confiance et in fine de la satisfaction de cette relation B to B. Afin de tester les hypothèses formulées, nous avons ensuite mené une étude empirique auprès de 93 fournisseurs de MDD de la Grande Distribution Alimentaire. Une première phase de collecte des données s’est déroulée au salon MDDEXPO en avril 2014 et a permis de recueillir 51 questionnaires. La deuxième phase de collecte a été réalisée via le réseau social numérique professionnel VIADEO et a permis de recueillir 42 réponses. Puis, nous avons soumis notre modèle au test avec la méthode PLS sous le logiciel SMARTPLS3. Les résultats de cette recherche montrent que deux dimensions de la proximité permettent d’accroitre directement la satisfaction du fournisseur de MDD de la relation, sans « passer par la confiance du fournisseur de MDD envers son distributeur »Through the case of private label supplier in food sector, this thesis aims to show that the satisfaction of private label supplier can be explained by the proximity with his distributor. By adopting a positivist epistemological position and hypothetical-deductive approach, we conducted a literature review that allowed us to develop an integrative model made up of four dimensions: relational proximity, identity proximity, process proximity and geographical proximity. Then realized an empirical study alongside 93 suppliers of private label. A first data collection stage took place in MDDEXPO on April 2014 and has enabled to collect 51 questionnaires. The second phase of collection was done via VIADEO and which came up with 42 responses. Further, we submitted our model to test using PLS method under SMARTPLS3 software. The results of this research show that two dimensions of proximity have direct relationship with increasing private label supplier satisfaction. They are, in the order of importance of structural relations, level of cooperation (relational proximity) and adaptations (process proximity). They also indicate that three dimensions of proximity are used to increase the satisfaction of private label supplier. They are , in order of importance of structural relationships, identity proximity (shared values), social bonds (sub-scale relational proximity) and geographic proximity. Moreover, they show that two sub-dimensions of proximity do not significantly influence the confidence nor the satisfaction of private label supplier to its retailer. It is a question of information exchange (relational proximity) and idiosyncratic assets (process proximity)
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Post, Loren M. "Emotion Regulation Processes and Negative Mood Regulation Expectancies in the Relationship Between Negative Affect and Co-occurring PTSD and MDD." Case Western Reserve University School of Graduate Studies / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=case1389204561.
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SOUZA, Ricardo André Cavalcante de. "WE4UIV Web engineering for user interaction view." Universidade Federal de Pernambuco, 2008. https://repositorio.ufpe.br/handle/123456789/1489.
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Previous issue date: 2008Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
No mundo globalizado e competitivo, a sobrevivência de uma organização está relacionada a atrair e, principalmente, manter clientes (consumidores) através da prestação de serviços de qualidade. Atualmente, a forma mais usual de comunicação direta entre as organizações e seus (possíveis) clientes é através de aplicações baseadas na Web. Entre as vantagens deste tipo de aplicação estão a disponibilidade em tempo integral (24/7/365) e a facilidade de acesso, tendo em vista que o requisito inicial é apenas um computador com acesso à Internet. No contexto da disciplina de Engenharia de Software, as aplicações Web possuem características específicas que as diferem de aplicações tradicionais, especialmente no que se refere à interação com os usuários, e que devem ser consideradas adequadamente no processo de desenvolvimento. Entretanto, os processos de software tradicionais são dirigidos à funcionalidade e a parte do sistema responsável pela interação com os usuários é tratada com menor ênfase usualmente apenas na etapa de Implementação, ocasionando deficiências no produto e insatisfação dos usuários quanto ao uso do sistema. Neste cenário, este trabalho apresenta o método WE4UIV (Web Engineering User Interaction View), dirigido a modelos e baseado em componentes, cujo propósito é tratar os aspectos relacionados à visão de interação com os usuários de aplicações Web, nos níveis de análise e projeto, de modo a fornecer subsídios para orientar a etapa de Implementação. Além disso, visando acelerar e tornar menos manual a etapa de Implementação, este trabalho também apresenta uma ferramenta integrada a um ambiente de desenvolvimento para geração de código fonte a partir de artefatos de projeto descritos em UML. A abordagem apresentada neste trabalho pressupõe melhorias quantitativas no processo de desenvolvimento da visão de interação com os usuários, especificamente redução do tempo da etapa de Implementação e do índice de trabalho adicional causado por solicitações de mudança. A abordagem proposta é validada através de um processo de experimentação no contexto de um projeto real de desenvolvimento de software
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Neto, David Fernandes. "CoMDD: uma abordagem colaborativa para auxiliar o desenvolvimento orientado a modelos." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/55/55134/tde-04092012-155208/.
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O desenvolvimento orientado a modelos (Model Driven Development - MDD) é uma abordagem que tem ganhado cada vez mais espaço na indústria e na academia, trazendo grandes benefícios, como o aumento de produtividade. Uma forma de se trabalhar usando MDD em equipe é usando uma IDE (Integrated Development Environment) associada a um sistema de versionamento. Entretanto, trabalhar colaborativamente usando uma IDE associada a um sistema de versionamento pode trazer algumas complicações para o desenvolvimento como: conflitos de modelos, documentação descontinuada, dificuldades por parte dos interessados em usar sistemas de versionamento, etc. Nesse contexto, este trabalho propõe uma abordagem de uso de wiki para desenvolvimento de MDD, de modo que o desenvolvedor seja capaz de criar modelos, gerar código fonte, compartilhar e versionar os modelos e ainda documentar colaborativamente, de maneira mais simples e fácil do que abordagens tradicionais. Isso possibilita que mais usuários não desenvolvedores possam participar mais no processo de desenvolvimento e ainda permite o aumento de produtividade. Para tentar evidenciar de que é possível uma wiki ser usada para desenvolver software, foi criada uma Domain Specific Language - DSL em uma wiki e foram realizados três estudos de caso: um com estudantes do ensino médio e que representam os não desenvolvedores, um com quatro alunos de pós-graduação com experiência de desenvolvimento na indústria e o último estudo de caso foi realizado com 48 participantes entre desenvolvedores e alunos de pósgraduação em Ciências da Computação. Os estudos de caso mostraram que é viável usar uma wiki para desenvolvimento, que não desenvolvedores se adaptam bem à abordagem e que 86% dos desenvolvedores usariam a abordagem proposta se tivessem que trabalhar com MDD. Os estudos de caso também levantaram as principais barreiras para aumentar a aceitação da abordagem. Com isso, este trabalho apresenta além de uma abordagem relativamente inédita na literatura, resultados sobre uso de sistemas de versionamento, de IDEs e de desenvolvimento colaborativoThe Model Driven Development (MDD) is an approach that has gained more space in industry and academia, bringing great benefits such as increased productivity. One way of working in teams with MDD is using an IDE (Integrated Development Environment) with a versioning system. However, to collaboratively work with an IDE and a versioning system may have implications and problems for the development as: conflicts of models, documentation discontinued, difficulties for stakeholders to use versioning systems, etc. In this context, this work proposes an approach to use a wiki to develop MDD, so that the developer is able to create models, generate source code, sharing and versioning models and also to collaboratively document, in a more simple and easy way than the traditional approaches. This enables non developers can participate more in the development process and also allows increasing productivity. To try to show that a wiki can be used to develop software, we created a Domain Specific Language (DSL) in a wiki and were performed three case studies: one with high school students and represent the non developers, another one with four graduate students with experience in software development in the industry, and the last case study was conducted with 48 participants among developers and graduate students in Computer Science. The case studies showed the feasibility of using a wiki for development, that non developers adapted well to the approach and 86 % of the developers would use a wiki to develop MDD. The study also raised the main barriers to increase the acceptance of the approach. Therefore, this work presents also a relatively new approach in the literature and results on the use of versioning systems, IDEs and collaboratively development
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Grillo, Filipe Del Nero. "Uma ferramenta acessível de apoio à modelagem de software na Web." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/55/55134/tde-17072014-161506/.
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Com o aumento do uso das atividades de modelagem em processos de desenvolvimento de software, a participação de pessoas com deficiência visual em tais processos requer esforços dedicados para que os modelos sejam passíveis de entendimento, caso contrário essa participação fica comprometida. Os modelos são em sua maioria visuais e, portanto, seu processo de construção requer o posicionamento de elementos no espaço do documento por meio de um dispositivo de apontar, como o mouse, e sua leitura requer o uso da visão, uma vez que os diagramas são compostos não apenas por textos, mas também por elementos visuais como retângulos e arcos conectando-os. Neste contexto, o objetivo deste projeto foi desenvolver uma técnica textual para representação e interação com diagramas que possibilite que pessoas com deficiência visual sejam capazes de colaborar em projetos de software, tanto utilizando uma abordagem de desenvolvimento orientado a modelos, quanto em uma abordagem de desenvolvimento tradicional. Para atingir o objetivo proposto foi desenvolvido um protótipo de uma ferramenta Web, a AWMo (lê-se letra a letra: A-W-M-O), a partir da qual a edição de modelos pode ser realizada por meio de duas visões equivalentes: uma visão gráfica, na qual o engenheiro de software poderá inserir novos elementos no diagrama, posicioná-los e definir suas propriedades de modo visual; e uma visão textual, na qual o engenheiro de software pode inserir novos elementos, propriedades e relacioná-los utilizando uma gramática textual. Um estudo de caso foi conduzido para avaliar sua eficácia e os resultados mostraram que a linguagem textual desenvolvida não representa uma barreira para a utilização da abordagem proposta pela AWMo. Os resultados sugerem que a AWMo é uma opção viável para facilitar o acesso de deficientes visuais a modelos de software, ajudando a promover a colaboração e comunicação efetiva e de maneira independente entre usuários com e sem visão para atividades de modelagem de softwareWith the growth of modeling activities in software development processes, the participation of visually impaired users requires dedicated efforts so that the models are capable to be understood, otherwise this participation is compromised. The models are mostly visuals and, therefore, their construction process requires the positioning of elements in the document space with a pointing device, like the mouse, and their reading requires the use of vision, since the diagrams are composed not only by text, but also by visual elements such as rectangles and arcs connecting them. In this context, the goal of this project was to develop a textual technique to represent and interact with diagrams to allow visually disabled people to collaborate in software development projects, either using an model driven development approach or a tradicional development approach. To achieve the proposed goal, a prototype Web tool called AWMo was developed. The prototype allows the edition of models to be done in two distinct views: a graphical view, where the software engineer is able to insert new elements and define their position in a visual and traditional way; and a textual view, where the software engineer is able to insert new elements, their properties and relationships using a textual grammar. A case study was conducted to evaluate the efficacy of the approach and the results show that the textual language developed did not posed itself as a barrier to the use of the AWMo. The results suggest that AWMo is a viable option to allow the access of the visually impaired to software models, promoting collaboration and effective communication between sighted and blind users in software modeling activities, but most importantly, in an independent way
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BUARQUE, Almir da Silva Moreira. "OOM-NFR: Transformando Modelos i* em oo-method Com Base em Requisitos Não-funcionais." Universidade Federal de Pernambuco, 2012. https://repositorio.ufpe.br/handle/123456789/10415.
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SERPRO
Nos últimos anos, o paradigma de desenvolvimento de software dirigido a modelos tem se consolidado e ganho popularidade. Desta forma, um produto de software pode ser obtido através de transformações dos modelos de mais alto nível de abstração para os de mais baixo nível, sendo essa transformação guiada por metamodelos. Por exemplo, requisitos iniciais de um sistema de software podem ser transformados em modelos conceituais deste sistema. Observamos que, tanto a abordagem de modelagem de requisitos i* (iStar) como a linguagem de modelagem conceitual OO-Method (OO-M), têm ganho notoriedade no âmbito acadêmico e industrial. Nesta dissertação, estamos interessados em transformar modelos de requisitos iniciais, descritos em i*, em modelos conceituais especificados em OO-Method. Em particular, investigaremos como os requisitos não-funcionais (NFR) de produto, relacionados a softgoals internos a um ator sistema do i*, poderão ser analisados nas abordagens que transformam modelos de requisitos i* em modelos conceituais descritos em OO-Method. Erros e omissões dos requisitos não-funcionais têm impacto bastante negativo na qualidade do produto final: custos elevados de correção pós-implantação e inviabilização do projeto de software. Esses requisitos estão entre os mais caros e difíceis de corrigir. Nesta dissertação, é apresentada a proposta OOM-NFR, que analisa os softgoals internos a um ator sistema em modelos i* para verificar conflitos, prioridades e satisfação dos mesmos. Além disso, com base nos metamodelos i* de origem e OO-Method de destino, a proposta especifica um processo de transformação contendo regras que convertem uma instância de um modelo i* em outra instância do modelo OO-Method. Com o processo OOM-NFR, o modelo OO-M gerado reflete as prioridades dos softgoals especificados em i*. Para ilustrar e validar a proposta, foi concebido um exemplo de uma aplicação baseada num sistema real, utilizando-se a linguagem de transformação de modelos Query/View/Transformation (QVT) para automatizar e implementar essas transformações.
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Panaite, Vanessa. "A retrospective and prospective comparison of Hungarian children who have one or two episodes of depression." Scholar Commons, 2011. http://scholarcommons.usf.edu/etd/3738.
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Early onset depression is associated with high recurrence rates later in life. Recurrent depressive episodes during childhood may be particularly problematic, if additional episodes have a scarring effect that hinders healthy development. Distinguishing between first onsets and recurrences has been useful in understanding adult depression. This distinction has seldom been examined in pediatric depression, in part because it is difficult to enroll adequate samples of children with recurrent depression. We conducted archival analyses of carefully-diagnosed pediatric probands with depression first onset between ages of 4 and 12. Probands who reported one depressive episode (N = 435) were compared with probands who reported two depression episodes (N = 115) on clinical (treatment, comorbidities), psychosocial (negative life events (NLEs), parental psychopathology) and emotion regulation measures. Based on previous findings in older adolescents and adults, we hypothesized that probands with two MDEs will have higher comorbidity, parental psychopathology, more NLEs, and higher maladaptive emotion regulation scale scores than probands with one MDE. Surprisingly, probands with one and two MDEs were indistinguishable on psychological and pharmacological treatment variables. As expected, probands with two MDEs had lower age of first onset, higher maladaptive emotion regulation scores, higher rates of comorbid anxiety and reported more NLEs than probands with one MDE. Probands with two MDEs also spent a longer total time in episode; group differences remained after controlling for time spent depressed. Distinguishing between first onsets and recurrences is meaningful in pediatric depression.
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Pontén, Emeli. "Efficacy of repetitive transcranial magnetic stimulation (rTMS) in the treatment of major depressive disorder (MDD): a systematic overview of randomized controlled trials." Thesis, Örebro universitet, Institutionen för läkarutbildning, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-42910.
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Silva, Marco Aurélio Graciotto. "LOD: uma abordagem para desenvolvimento de objetos de aprendizagem multimídia e interativos." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/55/55134/tde-06122012-162839/.
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Objetos de aprendizagem (OA) compõem uma das abordagens adotadas para tratar a crescente complexidade da educação com auxílio de computadores, promovendo o reúso e a qualidade de materiais didáticos. Tais benefícios podem ser ampliados ao incluir questões de projeto instrucional e associá-las às características multimídias e interativas dos dispositivos computacionais, sistematizando-se a produção de objetos de aprendizagem. Nesse contexto, esta tese define uma abordagem para o desenvolvimento de objetos de aprendizagem multimídias e interativos considerando o cenário de televisão digital. Essa abordagem, denominada LOD (Learning Object Development) consiste de um modelo de processo ou processo-padrão para desenvolvimento de objetos de aprendizagem (SPLOD Standard Process for Learning Object Development), a partir do qual se define um processo (LODP Learning Object Development Process) adequado para a construção de objetos de aprendizagem como recursos educacionais abertos (análogos a software livre); de um método de desenvolvimento dirigido a modelos, denominado LODM (Learning Object Development Method), compreendendo a modelagem conceitual, instrucional e de interação do objeto de aprendizagem; e de um conjunto de ferramentas que estabelecem um protótipo de ambiente para o desenvolvimento de objetos de aprendizagem (LODE Learning Object Development Environment) considerando o método LODM e o processo LODP. A abordagem LOD foi preliminarmente avaliada quanto à engenharia de objetos de aprendizagem multimídia e interativos, representados por apresentações multimídia e aplicações interativas para televisão digital para a plataforma Ginga do Sistema Brasileiro de Televisão Digital (SBTVD). Os resultados apontam para os benefícios da abordagem integrada para o desenvolvimento, com a geração de objetos de aprendizagem multimídias e interativos de forma mais ágil e sistemática, além de promover o reúso desde os primeiros passos da modelagem dos objetos de aprendizagemLearning objects are an approach to address the increasingly complexity of computersupported education, fostering reuse and learning material quality. Such benefits can be improved by considering instructional design and the multimedia and interactivity features of current computing devices, providing a systematic method to develop learning objects. Considering such context, this thesis defines an approach to the development of multimedia and interactive learning objects, considering the digital television scenario. This approach is named LOD (Learning Object Development) and is composed of (1) a reference process (SPLOD Standard Process for Learning Object Development) from which we defined a process for learning objects development (LODP Learning Object Development Process) suitable for engineering of open educational resources; (2) a model-driven development method (LODM Learning Object Development Method) that integrates conceptual, instructional and interaction modeling of learning objects; and (3) a set of tools that establish a prototype for an environment for learning object development named LODE (Learning Object Development Environment). The LOD approach was evaluated with multimedia and interactive learning objects development realized as multimedia presentations and interactive digital television applications aimed at the Brazilian Digital Television System and its Ginga middleware. The results evince the benefits of the integrated approach, providing an agile and systematic development and fostering the reuse since the initial models of the learning object engineering process
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Meijsen, Joeri Jeroen. "Combining genome-wide association studies, polygenic risk scores and SNP-SNP interactions to investigate the genomic architecture of human complex diseases : more than the sum of its parts." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/33094.
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Major Depressive Disorder is a devastating psychiatric illness with a complex genetic and environmental component that affects 10% of the UK population. Previous studies have shown that that individuals with depression show poorer performance on measures of cognitive domains such as memory, attention, language and executive functioning. A major risk factor for depression is a higher level of neuroticism, which has been shown to be associated with depression throughout life. Understanding cognitive performance in depression and neuroticism could lead to a better understanding of the aetiology of depression. The first aim of this thesis focused on assessing phenotypic and genetic differences in cognitive performance between healthy controls and depressed individuals and also between single episode and recurrent depression. A second aim was determining the capability of two decision-tree based methods to detect simulated gene-gene interactions. The third aim was to develop a novel statistical methodology for simultaneously analysing single SNP, additive and interacting genetic components associated with neuroticism using machine leaning. To assess the phenotypic and genetic differences in depression, 7,012 unrelated Generation Scotland participants (of which 1,042 were clinically diagnosed with depression) were analysed. Significant differences in cognitive performance were observed in two domains: processing speed and vocabulary. Individuals with recurrent depression showed lower processing speed scores compared to both controls and individuals with single episode depression. Higher vocabulary scores were observed in depressed individuals compared to controls and in individuals with recurrent depression compared to controls. These significant differences could not be tied to significant single locus associations. Derived polygenic scores using the large CHARGE processing speed GWAS explained up to 1% of variation in processing speed performance among individuals with single episode and recurrent depression. Two greedy non-parametric decision-tree based methods - C5.0 and logic regression - were applied to simulated gene-gene interaction data from Generation Scotland. Several gene-gene interactions were simulated under multiple scenarios (e.g. size, strength of association levels and the presence of a polygenic component) to assess the power and type I error. C5.0 was found to have an increased power with a conservative type I error using simulated data. C5.0 was applied to years of education as a proxy of educational attainment in 6,765 Generation Scotland participants. Multiple interacting loci were detected that were associated with years of education, some most notably located in genes known to be associated with reading and spelling (RCAN3) and neurodevelopmental traits (NPAS3). C5.0 was incorporated in a novel methodology called Machine-learning for Additive and Interaction Combined Analysis (MAICA). MAICA allows for a simultaneous analysis of single locus, polygenic components, and gene-gene interaction risk factors by means of a machine learning implementation. MAICA was applied on neuroticism scores in both Generation Scotland and UK Biobank. The MAICA model in Generation Scotland included 151 single loci and 11 gene-gene interaction sets, and explained ~6.5% of variation in neuroticism scores. Applying the same model to UK Biobank did not lead to a statistically significant prediction of neuroticism scores. The results presented in this thesis showed that individuals with depression performed significantly lower on the processing speed tests but higher on vocabulary test and that 1% of variation in processing speed can be explained by using a large processing speed GWAS. Evidence was provided that C5.0 had increased power and acceptable type I error rates versus logic regression when epistatic models exist - even with a strong underlying polygenic component, and that MAICA is an efficient tool to assess single locus, polygenic and epistatic components simultaneously. MAICA is open-source, and will provide a useful tool for other researchers of complex human traits who are interested in exploring the relative contributions of these different genomic architectures.
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Biehn, Teresa L. "Examining the Underlying Dimensions of Posttraumatic Stress Disorder and Major Depressive Disorder Using the Proposed DSM-5 Diagnostic Criteria." University of Toledo / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1402575685.
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De, Preter Caitlynn. "Poly ADP-Ribose Protein (PARP) Inhibition Alleviates Behavioral Endophenotypes Due to Stress in a Rodent Double-Hit Model of Major Depressive Disorder (MDD)." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/honors/412.
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Research has revealed that current antidepressant treatment is less than adequate at alleviating behavioral endophenotypes associated with major depressive disorder (MDD) and there is a need for appropriate animal models to validate novel antidepressant pharmacological targets. In the present study, we wished to establish an ethologically relevant social defeat stress model in combination with a chronic unpredictable stress model, to more accurately mimic severe stress that is common in MDD. Before each day of the introduction of the stressor, animals were given saline or a 40 mg/kg dose of 3-aminobenzamide (3-AB), a poly ADP-ribose (PARP) inhibitor. PARP is a DNA repair enzyme that is increased in activity in response to DNA oxidation, which is elevated in the prefrontal cortical white matter in MDD post-mortem donors. One stressed group was given the common antidepressant fluoxetine (10mg/kg) to serve as a positive control. Results of this study demonstrated that 3-AB alleviated decreases in sucrose preference, a natural reward, along with avoidance on a social interaction test given at the end of social defeat. Preliminary telemetry readings indicated 3-AB was able to significantly decrease heart rate and blood pressure in response to SDS as compared to saline treated rats. Therefore, it appears that PARP inhibition alleviated behavioral endophenotypes associated with stress and represents a new pharmacological treatment for MDD in humans.
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SILVA, Edson Alves da. "Um catálogo de regras para transformação automática de esquemas EER em código SQL-Relacional: uma visão MDD com foco em restrições estruturais não triviais." Universidade Federal de Pernambuco, 2015. https://repositorio.ufpe.br/handle/123456789/18303.
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CNPq
Model Driven Development (MDD) é um paradigma para geração automática de código executável que utiliza modelos como o seu artefato primário. No escopo de Banco de Dados, apesar das regras para transformação de esquemas Enhanced Entity Relationship (EER) em código da Structured Query Language (SQL)-Relacional já terem sido amplamente exploradas na literatura, não se encontrou um trabalho que ao mesmo tempo especifique tradutores MDD capazes de transformar, automaticamente, esquemas EER em códigos SQL-Relacional e aborde restrições como: Participação em Relacionamento, Disjunção e Completude em Herança ou Categoria são transformadas em estruturas SQL-Relacional. Neste contexto, visando dar uma contribuição às limitações mencionadas, esta dissertação apresenta duas macros contribuições: 1) um Catálogo de regras para transformar um esquema EER em um esquema Relacional e este em código SQL; e 2) um algoritmo que especifica uma ordem correta para a execução automática destas regras. De modo a mostrar a viabilidade e aplicação prática deste trabalho, o Catálogo de regras de transformação e o algoritmo para automatização do Catálogo são codificados na linguagem Query/View/Transformation-Relations (QVT-R) e implementados na ferramenta EERCASE. A avaliação do trabalho foi feita a partir da transformação de esquemas EER (não triviais) em códigos SQLRelacional, os quais são conferidos por especialistas de Banco de Dados. Por fim, comparando o trabalho proposto com os trabalhos relacionados investigados, constatou-se que o trabalho desta dissertação avança o estado da arte, pois é o único que é baseado em MDD e garante que as restrições de Participação em Relacionamento, Disjunção e Completude em Herança ou Categoria sejam automaticamente geradas para serem garantidas diretamente pelo Sistema de Gerenciamento de Banco de Dados.
Model Driven Development (MDD) is a paradigm for automatic generation of executable code that uses models as its primary artifact. In the database scope, despite the rules for transformation of Enhanced Entity Relationship (EER) schemas in code of Structured Query Language (SQL)-Relational have already been widely explored in the literature, we did not find a work that, at the same time, specifies MDD translators capable of transforming, automatically, EER schemas in SQL-Relational codes and addresses restrictions such as: Participation in Relationship, Disjunction and Completeness in Inheritance or Category are transformed into SQL-relational structures. In this context, in order to contribute for the mentioned limitations, this dissertation presents two macro contributions: 1) a rule Catalog to transform an EER schema into a Relational schema and this SQL code; and 2) an algorithm that specifies a correct order for the automatic enforcement of these rules. In order to show the feasibility and practical application of this work, the Catalog of transformation rules and the algorithm for Catalog automation are encoded in Query/View/TransformationRelations (QVT-R) language and implemented in EERCASE tool. The evaluation of the work was made from the processing of EER schemas (nontrivial) in SQL-Relational codes, which are conferred by database experts. Finally, comparing the proposed work with the related work investigated, it was found that the proposed work advances the state of the art, as it is the only one that is based on MDD and ensures that the restrictions on Participation in Relationship, Disjunction in Inheritance and Completeness in Inheritance or Category are guaranteed by the Database Management System.
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Shappee, Bartlett A. "Test First Model-Driven Development." Digital WPI, 2012. https://digitalcommons.wpi.edu/etd-theses/339.
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Test Driven Development (TDD), Model-Driven Development (MDD), and Test Case Generation with their associated practices and tools each in their own right promise to deliver robust higher quality code more economically then other approaches. These process are not mutually exclusive but are not typically used together. This thesis develops a combined approach using complimentary aspects of each of the above three process. Test cases are described, generated, and then injected back into the model, which is then used to produce the test and production code. We have enhanced a model-driven tool to support the approach, adding a test case generator, capable of understanding augmented MDD software model and utilizing the constraints captured in our test-centric language to generate model-level test cases back into the model. Our results show that, with a reduction in overall effort one can produce a tested model-based system in which its test and implementation for multiple platforms such as C and Java, using one of multiple test xUnit frameworks.
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Linardatos, Eftihia. "Qualitative and quantitative differences of worry among individuals with and without generalized anxiety disorder." [Kent, Ohio] : Kent State University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=kent1216644679.
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LIBÓRIO, Luiz Felipe de Oliveira. "Desenvolvimento baseado em modelos de ferramentas para avaliação da aderência de processos de software em relação a modelos de maturidade." Universidade Federal de Pernambuco, 2014. https://repositorio.ufpe.br/handle/123456789/17729.
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Capes
Atualmente, é cada vez mais exigido como critério competitivo a aderência do processo de software de uma organização a um modelo ou norma de qualidade. Alcançar altos níveis de aderência é uma tarefa complexa para as organizações, pois a atividade de avaliar essa aderência exige cuidado ao ser realizada. Com isso, busca-se cada vez mais o apoio de ferramentas de avaliação computadorizadas, cujo objetivo é agilizar e tornar mais confiável o processo de avaliação dos processos de software. Ainda assim, um dos fatores que tendem a dificultar a utilização e propagação do uso de ferramentas é a atualização das normas de qualidade e dos métodos de avaliação associados, que visam se adequar constantemente às boas práticas do mercado. Ora, se uma ferramenta é criada baseada na norma de qualidade e no seu método de avaliação, qualquer mudança em algum dos dois componentes significa mudanças na ferramenta, gerando custos de manutenção e de distribuição da nova versão da ferramenta. Este trabalho busca criar uma engine de geração que seja sensível a esses mudanças, sem que seu processo de desenvolvimento necessite ser executado novamente. Para isto, utiliza o processo MDD (Model-Driven Development) para atender a esses requisitos, dado que o seu objetivo é transformar elementos mais abstratos em elementos mais concretos utilizando uma sucessão de transformações, através de modelos. O objetivo deste trabalho é, então, aplicar as regras de MDD aos modelos de qualidade e métodos de avaliação. Isto torna possível a criação de ferramentas para avaliação baseada nos modelos necessários à avaliação. Ou seja, através de um modelo de processo e de um metamodelo da norma de qualidade, além do método de avaliação, é possível criar de forma automática via MDD uma ferramenta que possa ser atualizada sob demanda, sem que seu código-fonte precise ser alterado manualmente.
Nowadays, it is increasingly required as a competitive criteria the adherence of an organization to a software model or quality standard process. Achieving high levels of adherence is a complex task for organizations, because the activity of evaluating this adherence requires care to be performed. Thus, it is increasing the nedd of computerized evaluation tools whose goal is to speed up and make more reliable the process of evaluating software processes.Still, one of the factors that tend to hamper the use and propagation of tool use is the change of the quality standards and assessment methods, which aim to adapt constantly to best practices in the market. So, if a tool is created based on quality standard and its evaluation method, any change in any of the two components mean changes in the tool, generating costs of maintaining and distributing the new version of the tool. This work seeks to develop a tool that is sensitive to that changes, but without the need of performing its development process again. For that, it uses MDD (Model- Driven Development) processes meet these requirements, since their goal is to transform more abstract elements into more concrete elements using a succession of transformations, through models. So, the goal of this work is to apply the rules of MDD to quality models and assessment methods. It makes possible to create tools based on models. In other words, through a process model and a metamodel quality standard, besides the evaluation method, it is possible to create automatically via MDD a tool that can be updated on demand, without its source code need to be changed manually.
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Jalal, Kerollos. "Utforskandet av det nya materialet White Wood." Thesis, Högskolan i Gävle, Industridesign, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-33021.
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Jordens resurser används åt att tillfredsställa människans livsstil vilket har lett till att jorden har börjat säga ifrån genom klimatförändring eftersom den inte klarar av det som människan gör. Hållbarhet är ett av de viktigaste ämnena i dagens samhälle och aldrig har det varit viktigare att tänka på miljön och hur man inte skadar den. Hållbarhet är ett ämne som det bedrivs mycket forskning kring, vilket företaget RISE lägger stora resurser på. De har tagit fram ett nytt material som baseras på träavfall, eftersom de vill undersöka ifall människan kan återanvända något som inte har ett värde och ge det ett nytt värde och nytt liv. I ett samarbete med RISE har jag undersökt detta material som kallas för White Wood och fått i uppdrag att hitta ett användningsområde för materialet baserat på dess egenskaper. Forskningen kring White Wood har inte ännu kommit till stadiet där det kan börja produceras i stor skala, då det krävs en hel del fortsatta studier innan det steget kan tas. Målet med min studie har varit att hitta ett lämpligt användningsområde för White Wood när det är redo att ta det steget. Jag har använt mig av Material Driven Design metoden då detta är ett materialdrivet arbete som utgår ifrån materialets egenskaper och möjligheter. Jag har haft ett öppet sinne och låtit materialet och utforskandet av detta ta mig framåt, men mina tidigare erfarenheter och kunskaper har också varit till stor nytta. Genom att utmana och testa gränserna för White Wood så har jag upptäckt unika egenskaper och tillverkningsmetoder. Denna summering använde jag mig av för att sedan kunna placera White Wood inom elektronikområdet och ge konkreta produktförslag. Jag hoppas att mitt bidrag inom denna forskning kommer till nytta och kan inspirera till ökad hållbarhet nu och för framtiden.
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Sjöqvist, Jennie. "Hållbara materialkonstruktioner med hjälp av biomimicry." Thesis, Malmö universitet, Fakulteten för kultur och samhälle (KS), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-22679.
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Vi behöver minska vår materialkonsumtion, idag gör vi av med mer resurser än vad vi har tillgång till. I den här studien har först en materialkonstruktion tagits fram och därefter ett produktkoncept för konstruktionen. För att ta fram materialkonstruktionen har biomimicry använts. Biomimicry är designmetoder för att lösa designproblem med inspiration från naturen. Naturen använder sig av så lite material som möjligt. Materialkonstruktionen är inspirerad av växtceller. Konstruktionen har två hierarkier som går i två olika riktningar, en riktning som går längs med och en riktning som går i djupled.För att hitta ett produktkoncept för materialkonstruktionen har material driven design (MDD) använts. MDD är en experimentell metod för att lära känna ett material och förstå dess användningsområde. Produktkonceptet är en stapelbar pall.För att minska på resurser används 3d-printning. 3d-printning är en additiv teknik och minskar på så sätt materialåtgång. Dessutom kan allt material lätt återanvändas eftersom det bara behövs ett material.Produkten kan produceras lokalt vilket minskar på transporter. PLA har använts som material i den här studien.We need to reduce our material consumption, today we are wasting more resources than we have access to. In this study, a material construction was first developed and then a product concept for the construction. Biomimicry has been used to develop the material construction. Biomimicry are design methods for solving design problems with inspiration from nature. Nature uses as little material as possible. The material construction is inspired by plant cells. The construction has two hierarchies that go in two different directions.To find a product concept for the construction, material driven design (MDD) has been used. MDD is an experimental method used to get to know a material and understand its application. The product concept is a stackable pallet.To reduce resources, 3D printing is used. 3D printing is an additive technology and thus reduces material consumption. In addition, all material can be easily reused as only one material is needed.The product can be produced locally, which reduces on transport. PLA has been used as material in this study.
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Diallo, Mbaye Fall. "Les déterminants du choix des marques de distributeur : application à un marché émergent : le Brésil." Thesis, Aix-Marseille 3, 2011. http://www.theses.fr/2011AIX32039.
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La question de l’assortiment des produits dans les magasins est devenue un enjeu stratégique majeur pour pénétrer les nouveaux marchés et fidéliser les clients. La forte progression des marques de distributeur (MDD) face aux marques nationales (MN) et l’internationalisation croissante des enseignes de distribution sont deux bouleversements qui ont particulièrement retenu l’attention des chercheurs et des praticiens ces dernières années.Dans ce contexte, la problématique centrale de cette thèse est de comprendre les facteurs explicatifs du comportement d’achat envers les produits MDD. Dans le cadre d’une posture épistémologique hypothético-déductive, nous adoptons une approche psycho-cognitive tout en prenant en compte les travaux issus de l’achat impulsif. Dans ce sens, une revue des travaux antérieurs combinée à une étude qualitative exploratoire multi-méthodes (étude documentaire, entretiens avec 24 consommateurs et entretiens 8 managers) a été effectuée au Brésil. Nous avons par la suite conçu un modèle conceptuel intégrateur des déterminants du choix de la MDD, formulé des hypothèses de recherche et effectué les tests de validation avec un échantillon de 600 consommateurs brésiliens. Les résultats ont permis de valider une nouvelle échelle de mesure bidimensionnelle de l’image prix perçue des MDD. Ils montrent aussi que les facteurs explicatifs du choix de la MDD sont multiples et de nature diverse (perception de la valeur des MDD, attitude générale envers les MDD, perception de l’image du magasin, image prix perçue des MDD, familiarité avec le magasin, etc.). Ils indiquent également que l’importance des relations structurelles du modèle varie en fonction du caractère international ou local de l’enseigne.La discussion des résultats aboutit à la formulation de recommandations managériales (variables qui affectent le plus le comportement d’achat envers les MDD des enseignes étudiées et la perception de l’image du magasin) et méthodologiques (orthogonalisation pour tester la modération des variables latentes de second ordre). La conclusion synthétise les apports, limites et voies de recherche futuresThe question of product and brand assortment within the stores has become a major strategic challenge to penetrate new markets and retain customers. Two changes that have particularly caught the attention of researchers and practitioners are the strong growth of store brands (SBs) compared to national brands (NB) and the increasing internationalization of retail chains.In this context, the central issue of this thesis is to understand factors explaining purchase behavior toward SB products. In this sense, a review of previous work combined with a qualitative multi-method study (desk research, interviews with 24 consumers and 8 managers) was conducted in Brazil. We then developed an integrated conceptual model of the determinants of SB choice, proposed research hypotheses and performed the validation tests with a sample of 600 Brazilian consumers.The results allow us to validate a new two-dimensional scale of SB perceived price-image. They also show that factors explaining SB choice are numerous and diverse in nature (SB perceived value, general attitude towards SBs, store image perceptions, perceived SB price-image, etc.). They also indicate that the importance of the structural paths in the model depends on the retailer as local or international.The discussion of the results leads to managerial recommendations (variables that most affect purchase behavior toward SBs and store image perceptions) and methodological ones (orthogonalization to test the moderation of second order latent variables). The conclusion summarizes the contributions, limitations and future research avenues
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Lorio, Ryan. "Feasibility of Determining Radioactivity in Lungs Using a Thyroid Uptake Counter." Thesis, Available online, Georgia Institute of Technology, 2005, 2005. http://etd.gatech.edu/theses/available/etd-08102005-173443/.
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Thesis (M. S.)--Mechanical Engineering, Georgia Institute of Technology, 2006.Ansari, Armin, Committee Member ; Hertel, Nolan, Committee Chair ; Wang, Chris, Committee Member. Includes bibliographical references.
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Rojas, Poblete Cristián Andrés. "Incorporación Sistemática de Requisitos de Seguridad de Software." Tesis, Universidad de Chile, 2008. http://www.repositorio.uchile.cl/handle/2250/104889.
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Saxena, Ankita. "A Semantically Enhanced Approach to Identify Depression-Indicative Symptoms Using Twitter Data." Wright State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=wright152764172911888.
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Andersson, Filip. "Effekter av dynamisk leveldesign : Baserat på Multiplayer Dynamic Difficulty Adjustment." Thesis, Högskolan i Skövde, Institutionen för informationsteknologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-13735.
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I denna studie har effekterna av en dynamisk leveldesign undersökts som baserat sig på konceptet Multiplayer Difficulty Adjustment. Konceptet baseras på flera olika källor men handlar igrunden om att behålla spelare i Flow.Baldwin (2014)gjorde en undersökning där effekterna av en ändring till HP för den förlorande spelaren utvärderades. Till skillnad har denna studie ändrat på nivåns design för att undersöka dess effekter och eventuella likheter till Baldwin. Det gjordes med spelet CS: GO (2013) där en egengjord nivå skapades medett system som simulerade en dynamisk förändring i nivån.Med denna nivå utfördes studien med 24 deltagare där matchstatistik, kvantitativadata och kvalitativa intervjuer samlades in. Även om deltagarantalet var lågt, så kan man se tydliga indikationer på att systemet balanserar ut spelet för deltagarna. Man kan även dra slutsatsen från intervjuerna att deltagarna föredrarsystemet men att det enbart får inkluderas i ”casual” spellägen.
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Belix, José Eduardo. "Um estudo sobre MDA: suporte fornecido pela UML e reuso de soluções pré-definidas." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/3/3141/tde-11052006-165548/.
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Este trabalho tem por objetivo propor a utilização de soluções pré-definidas e comprovadas na abordagem MDA, auxiliando o desenvolvedor na resolução de problemas recorrentes ao desenvolvimento de software. A utilização destas soluções pré-definidas leva a um aumento de produtividade no contexto MDA e na geração de software baseado em boas práticas. Para que este objetivo seja cumprido, é empreendida uma análise sobre o MDA e sobre como operacionalizar as transformações entre modelos. Também é empreendida uma análise sobre o suporte fornecido pela UML e sobre reutilização em desenvolvimento orientado a modelos. Por fim este trabalho apresenta partes de uma aplicação protótipo, construída para ser uma prova de conceito de código gerado através da combinação de UML e soluções pré-definidas.The goal of this work is to propose the use of pre-defined solutions on MDA approach, supporting the developer in solving recurrent problems of software development. The use of these pre-defined solutions leads to an increase of productivity in MDA context, and in the generation of software based on best practices. To reach this goal, an analysis of MDA is undertaken, as well as an analysis of how to enable the transformations between models. It is also undertaken an analysis about the use of UML and the reuse in model driven development. Finally this work presents portions of a prototype application, constructed to be a proof-of-concept of generated code, combining UML and the pre-defined solutions.
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Berg, Jonatan. "Ett nytt användningsområde för materialet OrganoComp® : genom en materialdriven designprocess." Thesis, Högskolan i Gävle, Design och formgivning, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-28380.
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Syftet med detta projekt är att med hjälp av en materialinriktad designprocess skapa en produkt av biokompositmaterialet OrganoComp® för att demonstrera dess styrkor och möjligheter. Arbetet kommer att följa metoden ”Material Driven Design (MDD)”, vilket betyder att processen kommer att börja med en noggrann studie av materialet – dels tekniskt och ur ett användarcentrerat perspektiv, men även jämförelsemässigt mot andra material. Insikterna från dessa studier kommer sedan trattas ner och sammanfattas i en ”designintention” som ska sätta målet för designarbetet. Slutligen kommer ett antal koncept som uppfyller designintentionen arbetas fram, varav ett koncept – ett litet, ihopvikbart och nedbrytbart paraply/regnskydd kommer att väljas ut som det slutgiltiga. Paraplyet visar på materialets vattenavvisande egenskaper, i kombination med hårdhet och vikbarhet. Målet med projektet är att skapa en demonstrator som även har potential att bli en användbar produkt i framtiden, och samtidigt ge företaget OrganoClick nya insikter och flera förslag på nya användningsområden för sitt material.
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Moberg, Casper, and Niklas Kant. "CE-märkning av medicintekniska produkter ur ett nystartat företags perspektiv." Thesis, KTH, Skolan för teknik och hälsa (STH), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-192322.
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Regelverket för medicintekniska produkter är omfattande och medicintekniska företag lägger idag stora resurser på att säkerställa att deras produkter uppfyller de lagar och krav som finns. Detta arbete beskriver författarnas bidrag till CE-märkningsprocessen på det nystartade företaget LARA Diagnostics första produkt, en handhållen enhet för utvärdering av perifer neuropati samt hur processen att CE-märka en medicinteknisk produkt generellt går till för ett mindre eller nystartat företag. Arbetet syftar till att visa vilka utmaningar mindre bolag har i synnerhet vid processen att CE-märka sin första produkt samt vad företag kan göra för att effektivisera sin process. I arbetet visas att mindre företag kan effektivisera sin process genom att: Tidigt lägga grunden till CE-märkningen. Se till att rätt kompetens finns eller införskaffas utifrån Redan i produktutvecklingen säkerställa att väsentliga krav uppfylls, gärna genom att följa harmoniserade standarder. Arbetet visar även att kraven inom det regulatoriska området för medicintekniska produkter blir hårdare med tiden och att den utvecklingen förväntas fortsätta.The regulatory framework for medical devices is extensive and the medical device industry spends considerable resources on ensuring that their products comply with existing laws and requirements. This paper describes the authors’ contribution to the CE marking process of the very first product from the startup company LARA Diagnostics, a handheld device for the evaluation of peripheral neuropathy, as well as how the process of CE marking a medical device is carried out in general for a small or startup business. The work aims to point out the challenges for smaller companies in particular to get their first product certified, but also what can be done to streamline that process. The paper shows that small companies can improve the process by: Laying the foundation for CE marking early in the process. Ensure that the right skills exist internally or are acquired externally. Making sure that essential requirements are met early in the product development life cycle, preferably by adhering to harmonized standards. The paper also shows that the requirements within the regulatory framework for medical devices are becoming stricter over time and that this trend is expected to continue.
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Torres, Alexandre. "MD-JPA : um perfil UML para modelagem do mapeamento objeto-relacional com JPA em uma abordagem dirigida por modelos." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2009. http://hdl.handle.net/10183/17797.
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A abordagem de desenvolvimento dirigido por modelos (DDM) propõe que modelos (e transformações entre modelos) assumam o papel principal no desenvolvimento de sistemas. Entretanto, não há uma notação consensual para modelagem de persistência baseada em arcabouços de mapeamento objeto-relacional: enquanto a UML não possui recursos específicos para a modelagem de persistência, o modelo entidade-relacionamento não expressa os conceitos dinâmicos existentes na UML. Este trabalho propõe o perfil UML MD-JPA (Model Driven JPA) para a modelagem de persistência baseada na já difundida API de persistência Java (JPA), buscando a modelagem dos elementos persistentes e transientes de forma mais coerente e integrada. São especificadas as principais características do perfil MD-JPA, assim como a maneira pela qual modelos que adotam este perfil podem ser transformados em implementação Java, através de transformações de modelos propostas em uma abordagem DDM. Por fim, uma ferramenta de código livre foi desenvolvida para disponibilizar para comunidade os resultados deste trabalho.The model driven development (MDD) approach proposes that models (and modelto- model transformations) play the main role on system development. However, there is not a consensual notation to model persistence based upon object relational mapping frameworks: while UML lacks specific resources for persistence modeling, the entityrelationship model does not make reference to the dynamic concepts existing in UML. This work proposes MD-JPA, a UML profile for persistence modeling based on the well-known Java Persistence API (JPA), pursuing the modeling of transient and persistent elements in a more coherent and integrated way. This work describes the main characteristics of MD-JPA as well as the way that models that adopt such profile can them be used to generate a Java implementation by the application of the proposed model transformations on a MDD approach. Finally, an open source tool was developed to make the results of this work available to the community.
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Ramano, Enos Morankoana. "Perceptions and practices of occupational therapists in determining work capacity of employees suffering from major depressive disorder." Diss., University of Pretoria, 2011. http://hdl.handle.net/2263/24799.
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Major depressive disorder (MDD) is a relevant condition to consider regarding Work Capacity Evaluation (WCE) because of its high prevalence, strong impact on short-term work disability, and low rate of treatment. The challenge that faces occupational therapists (OTs) is that there is no specific guideline and process to follow when conducting Work Capacity Evaluation with clients suffering from MDD. The researcher had also noted conflicting opinions with regard to the outcome of Work Capacity Evaluation (WCE) and recommendations in occupational therapy reports. The researcher is of the opinion that indeed occupational therapy assessments need to be clear about what to measure, and selection of appropriate standardised measures and non-standardised assessments is needed. Therefore, the research question was, what are the perceptions and practices of occupational therapists in determining work capacity of employees suffering from major depressive disorder? The aim of this study was to describe the perceptions and practices of occupational therapists in determining work capacity of employees suffering from major depressive disorder. The literature showed that Work Capacity Evaluation assists to determine the employee’s returnto- work. The Code of Good Practice: Dismissal contained in the Labour Relations Act of 1998, stipulates that incapacity on the ground of ill health or injury may be either temporary or permanent. The nature of this study was a mixed method design including both qualitative and quantitative approaches. The phenomenological strategy was used. The study had a sample size of 68 participants, practising as occupational therapists. Purposive sampling was used. The data were collected in four distinct phases, referred to as sequential exploratory strategy with elements of embedded design. Phase one, used descriptive open-ended questions; phase two was a close-ended questionnaire to confirm findings in phase one; phase three consisted of focus group interviews and phase four was member checking to confirm findings in phase three. During data analysis, five themes related to employees suffering from MDD emerged and they were identified as: (1) the content of comprehensive assessment for work capacity evaluation, (2) the process of work capacity evaluation, (3) the competency requirements of the occupational therapist, (4) occupational performance and (5) formulating return-to-work decision. Recommendations related to the five themes were formulated and suggestions for future research proffered. The study clarified and confirmed that occupational therapists have a major role to play in performing work capacity of employees suffering from major depressive disorder, and that they need to be competent in performing these evaluations. CopyrightDissertation (MOccTher)--University of Pretoria, 2011.
Occupational Therapy
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Serral, Asensio Estefanía. "Automating Routine Tasks in Smart Environments. A Context-aware Model-driven Approach." Doctoral thesis, Universitat Politècnica de València, 2011. http://hdl.handle.net/10251/11550.
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Ubiquitous and Pervasive computing put forth a vision where
environments are enriched with devices that provide users with
services to serve them in their everyday lives. The building of such
environments has the final objective of automating tedious routine tasks
that users must perform every day.
This automation is a very desirable challenge because it can
considerably reduce resource consumption and improve users' quality of
life by 1) making users' lives more comfortable, eficient, and productive,
and 2) helping them to stop worrying and wasting time in performing
tasks that need to be done and that they do not enjoy. However, the
automation of user tasks is a complicated and delicate matter because
it may bother users, interfere in their goals, or even be dangerous. To
avoid this, tasks must be automated in a non-intrusive way by attending
to users' desires and demands.
This is the main goal of this thesis, that is, to automate the routine
tasks that users want the way they want them. To achieve this, we
propose two models of a high level of abstraction to specify the routines
to be automated. These models provide abstract concepts that facilitate
the participation of end-users in the model specification. In addition,
these models are designed to be machine-processable and precise-enough
to be executable models.
Thus, we provide a software infrastructure that is capable of
automating the specified routines by directly interpreting the models at
runtime. Therefore, the routines to be automated are only represented
in the models. This makes the models the primary means to understand,
interact with, and modify the automated routines. This considerably
facilitates the evolution of the routines over time to adapt them to
changes in user behaviour. Without this adaptation, the automation of
the routines may not only become useless for end-users but may also
become a burden on them instead of being a help in their daily life.Serral Asensio, E. (2011). Automating Routine Tasks in Smart Environments. A Context-aware Model-driven Approach [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/11550
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