Academic literature on the topic 'Matrix composition alteration'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Contents
Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Matrix composition alteration.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Journal articles on the topic "Matrix composition alteration"
1
AlJamal-Naylor, Rehab, Linda Wilson, Susan McIntyre, Fiona Rossi, Beth Harrison, Mark Marsden, and David J. Harrison. "Allosteric Modulation of Beta1 Integrin Function Induces Lung Tissue Repair." Advances in Pharmacological Sciences 2012 (2012): 1–16. http://dx.doi.org/10.1155/2012/768720.
Full textAbstract:
The cellular cytoskeleton, adhesion receptors, extracellular matrix composition, and their spatial distribution are together fundamental in a cell's balanced mechanical sensing of its environment. We show that, in lung injury, extracellular matrix-integrin interactions are altered and this leads to signalling alteration and mechanical missensing. The missensing, secondary to matrix alteration and cell surface receptor alterations, leads to increased cellular stiffness, injury, and death. We have identified a monoclonal antibody against β1 integrin which caused matrix remodelling and enhancement of cell survival. The antibody acts as an allosteric dual agonist/antagonist modulator of β1 integrin. Intriguingly, this antibody reversed both functional and structural tissue injury in an animal model of degenerative disease in lung.
2
Andersen, Pål Østebø, Steinar Evje, Hans Kleppe, and Svein Magne Skjæveland. "A Model for Wettability Alteration in Fractured Reservoirs." SPE Journal 20, no. 06 (December 18, 2015): 1261–75. http://dx.doi.org/10.2118/174555-pa.
Full textAbstract:
Summary We present a mathematical model for wettability alteration (WA) in fractured reservoirs. Flow in the reservoir is modeled by looking at a single fracture surrounded by matrix on both sides. Water is injected into the formation with a chemical component that enters the matrix and adsorbs onto the rock surface. These changes of the mineral surface are assumed to alter the wettability toward a more water-wet state, which leads to enhanced recovery by spontaneous imbibition. This can be viewed as a representation of “smart water” injection in which the ionic composition of injection brine affects recovery. The WA is described by shifting curves for relative permeability and capillary pressure from curves representing preferentially oil-wet (POW) conditions toward curves representing more-water-wet conditions. The numerical code was successfully compared with ECLIPSE for the specific case in which a fixed wetting state is assumed. Also, the relevance of the WA model was illustrated by modeling a spontaneous-imbibition experiment in which only a modification of the brine composition led to a change in oil recovery. The model can predict sensitivity to matrix properties such as wettability, permeability, and fracture spacing and to external parameters such as schedule of brine compositions and injection rate. Our model illustrates that one cannot use conventional reservoir modeling to capture accurately the behavior we observe. The rate of recovery and the level of recovery have a strong dependency on the component chemistry and its distribution. A significant feature of gradual WA by injecting a component is that the rate of fluid transfer is maintained between matrix and fracture. The resulting recovery profile after water breakthrough can behave close to linear as opposed to the square-root-of-time profile that is observed when the wetting state is fixed (Rangel-German and Kovscek 2002). The water will typically break through early as dictated by the initial POW state, but a higher final recovery will be obtained because higher saturations can imbibe. Improved understanding of the coupling between WA controlled by water/rock chemistry and fracture/matrix flow is highly relevant for gaining more insight into recovery from naturally fractured reservoirs.
3
Gerner, C., C. Seelos, and G. Sauermann. "Alteration of Nuclear Matrix Protein Composition during Apoptosis in Rat Embryo Cells." Experimental Cell Research 238, no. 2 (February 1998): 472–80. http://dx.doi.org/10.1006/excr.1997.3866.
Full text
4
HURT, Sean M., Alan E. RUBIN, and John T. WASSON. "Fractionated matrix composition in CV3 Vigarano and alteration processes on the CV parent asteroid." Meteoritics & Planetary Science 47, no. 6 (June 2012): 1035–48. http://dx.doi.org/10.1111/j.1945-5100.2012.01372.x.
Full text
5
Trakshel, G. M., and M. D. Maines. "Characterization of glutathione S-transferases in rat kidney. Alteration of composition by cis-platinum." Biochemical Journal 252, no. 1 (May 15, 1988): 127–36. http://dx.doi.org/10.1042/bj2520127.
Full textAbstract:
We have developed chromatographic and mathematical protocols that allowed the high resolution of glutathione S-transferase (GST) subunits, and the identification of a previously unresolved GST monomer in rat kidney cytosol; the monomer was identified tentatively as subunit 6. Also, an aberrant form of GST 7-7 dimer appeared to be present in the kidney. This development was utilized to illustrate the response of rat kidney GST following cis-platinum treatment in vivo. Rat kidney cytosol was separated into three ‘affinity families’ of GST activity after elution from a GSH-agarose matrix. The affinity peaks were characterized by quantitative differences in their subunit and dimeric compositions as determined by subsequent chromatography on a cation-exchange matrix and specific activity towards substrates. By use of these criteria, the major GST dimers of affinity peaks were tentatively identified. The major GST dimers in peak I were GST 1-1 and 1-2, in affinity peak II it was GST 2-2, and in peak III they were GST 3-3 and 7-7. GST 3-6 and/or 4-6, which have not been previously resolved in kidney cytosol, were also present in peak II. Alterations in the kidney cytosolic GST composition of male rats were detected subsequent to the administration of cis-platinum (7.0 mg/kg subcutaneously, 6 days). This treatment caused a pronounced alteration in the GST profile, and the pattern of alteration was markedly different from that reported for other chemicals in the kidney or in the liver. In general, the cellular contents of the GSTs of the Alpha and the Mu classes decreased and increased respectively. It is postulated that the decrease in the Alpha class of GSTs by cis-platinum treatment may be related to renal cortical damage and the loss of GSTs in the urine. The increase in the Mu class of GSTs could potentially stem from a lowered serum concentration of testosterone; the latter is a known effect of cis-platinum treatment.
6
Kassiri, Zamaneh, and Rama Khokha. "Myocardial extra-cellular matrix and its regulation by metalloproteinases and their inhibitors." Thrombosis and Haemostasis 93, no. 02 (2005): 212–19. http://dx.doi.org/10.1160/th04-08-0522.
Full textAbstract:
SummaryCardiovascular disease poses a major health care burden in the Western world. Following myocardial injuries, ventricular remodelling and dysfunction ensue, which can eventually culminate in heart failure. An important event in left ventricular (LV) remodelling is alteration of the extracellular matrix (ECM) integrity, the structural network that interconnects the myocardial components. The critical role of ECM remodelling in cardiac dilation and heart failure was recognized more than a decade ago, and the molecular factors responsible for this process are now being explored. Abnormal ECM turnover is primarily brought about by an imbalance in the activity of matrix metalloproteinases (MMPs) that degrade ECM components, and their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs). Here we provide an overview of composition of the cardiac ECM, and alterations in ECM regulatory proteins, MMPs and TIMPs, in human heart disease. We also discuss the role of TIMPs, MMPs, and a disintegrin and metalloproteinase (ADAMs) enzymes in cardiac development and function as learned through genetically altered mouse models.
7
Kubyshkin, Anatoly, Olga Pisareva, Yevgenia Bessalova, and Irina Fomochkina. "The prospects of using the silver nanoparticles composition in sodium alginate matrix." MATEC Web of Conferences 315 (2020): 09001. http://dx.doi.org/10.1051/matecconf/202031509001.
Full textAbstract:
A wide range of anti-inflammatory properties of the solution of nanosilver has found its application in medical practice. In this work, nano-silver was used in the treatment of burn wounds in combination with a proteinase inhibitor. An experimental model of a second-degree burn with the use of a nano-silver solution in combination therapy is accompanied by a decrease in the inhibitory potential at the local level and stimulation of regeneration processes, which indicates the anti-inflammatory effects of nano-silver particles. There is also a decrease in the morphological signs of inflammation in the burned areas of the skin of the therapeutic use of a solution of nano-silver. The results indicate that nano-silver solution for prophylactic and therapeutic use has the ability to block a cascade of inflammatory reactions in the focus of damage, as it is evidenced by a decrease in the degree of alteration and intensification of reparative processes in damaged tissues.
8
Mitchell, Roger H., Andrea Giuliani, and Hugh O’Brien. "What is a Kimberlite? Petrology and Mineralogy of Hypabyssal Kimberlites." Elements 15, no. 6 (December 1, 2019): 381–86. http://dx.doi.org/10.2138/gselements.15.6.381.
Full textAbstract:
Hypabyssal kimberlites are subvolcanic intrusive rocks crystallised from mantle-derived magmas poor in SiO2 and rich in CO2 and H2O. They are complex, hybrid rocks containing significant amounts of mantle-derived fragments, primarily olivine with rare diamonds, set in a matrix of essentially magmatic origin. Unambiguous identification of kimberlites requires careful petrographic examination combined with mineral compositional analyses. Melt inclusion studies have shown that kimberlite melts contain higher alkali concentrations than previously thought but have not clarified the ultimate origin of these melts. Because of the hybrid nature of kimberlites and their common hydrothermal alteration by fluids of controversial origin (magmatic and/or crustal), the composition of primary kimberlite melts remains unknown.
9
Zandanel, Amber, Kirsten B. Sauer, Marlena Rock, Florie A. Caporuscio, Katherine Telfeyan, and Edward N. Matteo. "Impacts of Crystalline Host Rock on Repository Barrier Materials at 250 °C: Hydrothermal Co-Alteration of Wyoming Bentonite and Steel in the Presence of Grimsel Granodiorite." Minerals 12, no. 12 (December 1, 2022): 1556. http://dx.doi.org/10.3390/min12121556.
Full textAbstract:
Direct disposal of dual-purpose canisters (DPC) has been proposed to streamline the disposal of spent nuclear fuel. However, there are scenarios where direct disposal of DPCs may result in temperatures in excess of the specified upper temperature limits for some engineered barrier system (EBS) materials, which may cause alteration within EBS materials dependent on local conditions such as host rock composition, chemistry of the saturating groundwaters, and interactions between barrier materials themselves. Here we report the results of hydrothermal experiments reacting EBS materials—bentonite buffer and steel—with an analogue crystalline host rock and groundwater at 250 °C. Experiment series explored the effect of reaction time on the final products and the effects of the mineral and fluid reactants on different steel types. Post-mortem X-ray diffraction, electron microprobe, and scanning electron microscopy analyses showed characteristic alteration of both bentonite and steel, including the formation of secondary zeolite and calcium silicate hydrate minerals within the bentonite matrix and the formation of iron-bearing clays and metal oxides at the steel surfaces. Swelling clays in the bentonite matrix were not quantitatively altered to non-swelling clay species by the hydrothermal conditions. The combined results of the solution chemistry over time and post-mortem mineralogy suggest that EBS alteration is more sensitive to initial groundwater chemistry than the presence of host rock, where limited potassium concentration in the solution prohibits conversion of the smectite minerals in the bentonite matrix to non-swelling clay species.
10
Hara, Eiki, Yoshitomo Honda, Osamu Suzuki, Tomonari Tanaka, and Naoyuki Matsumoto. "Epigallocatechin Gallate-Modified Gelatins with Different Compositions Alter the Quality of Regenerated Bones." International Journal of Molecular Sciences 19, no. 10 (October 19, 2018): 3232. http://dx.doi.org/10.3390/ijms19103232.
Full textAbstract:
Bone quality is a significant indicator of the result of bone treatments. However, information regarding the quality of regenerated bones is limited. The study investigates the effect of different compositions of vacuum heated epigallocatechin gallate-modified gelatins sponge (vhEGCG-GS) on the quality of regenerated bones in critical size defects (9 mm) of rat calvariae. Five different compositions of vhEGCG-GSs containing the same amount of EGCG and different amounts of gelatin were tested. Following four weeks after implantation, the harvested regenerated bones were evaluated by using micro-computed tomography analysis, histological evaluation (hematoxylin-eosin and Villaneueva Goldner staining), picrosirius red-staining with polarized microscopic observation for collagen maturation, and Fourier transform infrared spectroscopy microscopy and imaging analysis for mineral-matrix ratio. The results indicated that increasing content of gelatin in the vhEGCG-GSs promoted bone and osteoid formation but yielded porous bones. Furthermore, tissue mineral density decreased and the maximum mineral-matrix ratio increased. In contrast, vhEGCG-GSs containing smaller amount of gelatin formed mature collagen matrix in the regenerated bones. These results suggest that the alteration of composition of vhEGCG-GSs affected the bone forming capability and quality of regenerated bone and provides valuable insight for the fabrication of new bone substitute materials.
Books on the topic "Matrix composition alteration"
1
Goldring, Steven R. Pathophysiology of periarticular bone changes in osteoarthritis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0005.
Full textAbstract:
Under physiological conditions, the subchondral bone of diarthrodial joints such as the hip, knee, and phalanges forms an integrated biocomposite with the overlying calcified and hyaline articular cartilage that is optimally organized to transfer mechanical load. During the evolution of the osteoarthritic process both the periarticular bone and cartilage undergo marked changes in their structural and functional properties in response to adverse biomechanical and biological signals. These changes are mediated by bone cells that modify the architecture and properties of the bone through active cellular processes of modelling and remodelling. These same biomechanical and biological factors also affect chondrocytes in the cartilage matrix altering the composition and structure of the cartilage and further disrupting the homeostatic relationship between the cartilage and bone. This chapter reviews the structural alterations and cellular mechanisms involved in the pathogenesis of osteoarthritis bone pathology and discusses potential approaches for targeting bone remodelling to attenuate the progression of the osteoarthritic process.
Conference papers on the topic "Matrix composition alteration"
1
Schmidt, David E., W. David Merryman, and Michael S. Sacks. "Extracellular Matrix-Contractile Response Coupling of the Aortic Heart Valve Interstitial Cell." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-193171.
Full textAbstract:
The role of aortic valve interstitial cell (AVIC) and extracellular matrix (ECM) interactions of the aortic valve (AV) are not well understood. Distinct differences in the composition and structure of the AV leaflet layers (fibrosa and ventricularis) have been shown to influence mechanical properties 1. Our ability to measure the effects of changes in cellular stiffness in the dense collagenous AV leaflets (AVL) 2 offers a unique opportunity to explore the in-situ AVIC stiffness and local AVIC-ECM mechanical interactions. In the present study, a multi-scale finite element model approach was developed based on our simulations of our flexural stiffness experiment 2 were used to develop effective layer dependent mechanical properties. In addition, we present a predictive model for the alteration of AVL tissue mechanical properties resulting from AVIC contraction. This model provides a means to probe the layer dependent properties under the influence of AVIC contraction relative to an intact tissue state. By establishing a procedure to examine ECM stiffness in situ, through coupled experimental and computational methods, insights into relative contributions of ECM components were developed. Finally, in contrast previous study, where tissue stiffness was reported in terms on an instantaneous elastic modules, this work provides a more complete mechanical response of AVL in flexure.
2
Narmoneva, D. A., J. Y. Wang, S. S. Patel, D. S. Howell, and L. A. Setton. "Altered Swelling-Induced Strain Fields in Articular Cartilage Following Periods of Immobilization." In ASME 1997 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 1997. http://dx.doi.org/10.1115/imece1997-0260.
Full textAbstract:
Abstract Swelling effects in cartilage arise from a high density of negatively-charged proteoglycans which generate a large swelling pressure. Swelling effects in cartilage are regulated by a balance between this swelling pressure and elastic forces generated within the cartilage solid matrix (1,2). Increased swelling is a characteristic of osteoarthritic cartilage and reflects a pathological alteration in the balance between swelling pressure and elastic restraining forces (3). Recently, we have developed a new technique to measure the nonuniform swelling-induced strain fields in samples of articular cartilage in situ, i.e., while attached to the subchondral bone (4). We observed variations in swelling behavior of cartilage with depth from the articular surface, reflecting the nonhomogeneous composition and structure of the material. In this study, we apply our newly-developed experimental technique to measure the swelling-induced strain fields in cartilage following removal of weight-bearing forces with cast immobilization. Periods of joint immobilization have been shown to produce compositional changes characteristic of osteoarthritis including a decreased proteoglycan content and changes in proteoglycan conformation (5, 6). We hypothesize that the changes associated with joint immobilization will alter the swelling behavior of articular cartilage, which will be detected as a change in swelling-induced strain fields in cartilage in situ.
3
Guimera`, Jordi, Eduardo Ruiz, Miguel Luna, David Arcos, Cristina Dome`nech, Salvador Jordana, Hiromitsu Saegusa, and Teruki Iwatsuki. "Numerical Assessment of the Origin of Deep Salinity in a Low Permeability Fractured Medium." In The 11th International Conference on Environmental Remediation and Radioactive Waste Management. ASMEDC, 2007. http://dx.doi.org/10.1115/icem2007-7363.
Full textAbstract:
Many possible origins have been proposed for the saline groundwater observed in many deep geological environments. In particular, samples obtained from deep boreholes located in granite at the Mizunami Underground Research Laboratory in Central Japan show total dissolved solids increasing to 50 mmol/L at depths below 800 m. Different hypothesis have been formulated to explain the observed fluid composition, among them, long-term water-rock interaction, mixing with residual fluids of magmatic origin and relict seawater dating from Miocene times. A review of the hydrochemical and isotopic data suggests that the three above hypotheses may be valid, at least to different degrees, or that processes acting over more recent geological times may be involved. The origin of the salinity was assessed by simulating land emersion by means of changing the upper recharge boundary. In this manner the Miocene seawater was modeled as being continually mixed with fresh water until the present time. The effects of different retardation processes were considered by varying factors such as matrix diffusion and fracture conductivity. Finally, geochemical reactions reproduced trends in major ions and master variables. This study shows that the salinity observed in the boreholes can be explained qualitatively as residual Miocene age seawater subjected to alteration due to long-term contact with the host material and continuous mixing with meteoric groundwater.
4
Acosta, Juan C., Mark E. Curtis, Carl H. Sondergeld, and Chandra S. Rai. "Manuscript Title: Mechanical and Microstructural Studies of Volcanic Ash Beds in Unconventional Reservoirs." In SPE Annual Technical Conference and Exhibition. SPE, 2021. http://dx.doi.org/10.2118/206227-ms.
Full textAbstract:
Abstract Volcanic ash beds are thin layers commonly observed in the Eagle Ford, Niobrara and, Vaca Muerta formations. Because of their differences in composition, sedimentary structures, and diagenetic alteration, they exhibit a significant contrast in mechanical properties with respect to surrounding formation layers. This can impact hydraulic fracturing, affecting fracture propagation and fracture geometry. Quantifying the mechanical properties of ash beds becomes significant; however, it is a challenge with traditional testing methods. Common logging fails to identify the ash beds, and core plug testing is not possible because of their friability. In this study, nanoindentation was used to measure the mechanical properties (Young's modulus, creep, and anisotropy) in Eagle Ford ash beds, and to determine the contrast with the formation matrix properties. Two separate ash beds of high clay and plagioclase composition were epoxied in an aluminum tray and left for 48 hours curing time. Horizontal and vertical samples of ash beds were acquired and mounted on a metal stub, followed by polishing and broad beam ion milling. Adjacent samples were also prepared for high-resolution Scanning Electron Microscope (SEM) microstructural analysis. The Young's modulus in ash beds ranged from 12 to 24 GPa, with the horizontal direction Young's modulus being slightly greater than that of the vertical samples. The Young's modulus contrast with adjacent layers was calculated to be 1:2 with clay-rich zones and 1:4 with calcite rich zones. The creep deformation rate was three times higher for ash beds compared to other zones. Using Backus averaging, it was determined that the presence of ash beds can increase the anisotropy in the formation by 15-25%. SEM results showed a variation in microstructure between the ash beds with evidence of diagenetic conversion of rhyolitic material into clays. Key differences between the two ash beds were due to the presence of plagioclase and the occurrence of porosity within kaolinite. Overall porosity varied between the two ash beds and adjacent carbonate layers showing a significant increase in porosity. Understanding the moduli contrast between adjacent layers can improve the hydraulic fracturing design when ash beds are encountered. In addition, the presence of these beds can lead to proppant embedment and loss in fracture connectivity. These results can be used for improving geomechanical models.
5
Shen, Ninggang, Hongtao Ding, and Wei Li. "Predictive Modeling of Surface Microstructure of Hardened Steel Subject to Drilling." In ASME 2013 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/imece2013-64499.
Full textAbstract:
Hole surface microstructures are very critical to the mechanical performance and fatigue life of metallic products from drilling processes. When steel material is drilled at a fully hardened condition, hole surface microstructures are often subject to transition because of the intense thermo-mechanical loading in the drilling process. A white layer can be formed on the surface of a drilled hole of carbon steels with high matrix hardness. The formation of the white layer mainly results from two reasons: thermally driven phase transformation and mechanical grain refinement due to severe plastic deformation on the machined surface. In this study, a multi-step numerical analysis is conducted to investigate the potential mechanism of surface microstructure alterations in the drilling process of hardened steels. First, three-dimensional (3D) Finite Element (FE) simulations are performed using a relative coarse mesh with AdvantEdge for hard drilling of AISI 1060 steel to achieve the steady-state solution for thermal and deformation fields. Defining the initial condition of the cutting zone using the previous 3D simulation results, a multi-physics model is then implemented in two-dimensional (2D) coupled Eulerian-Lagrangian (CEL) finite element analysis in ABAQUS to model both phase transformation and grain refinement at a fine mesh to comprehend the surface microstructure alteration. The interaction among surface microstructures, drilling parameters and the hardness of the workpiece material are studied simultaneously. With the comparison to related experimental results, the capabilities of the multi-physics model to accurately predict critical surface microstructural attributes such as phase compositions, grain size, and microhardness during the drilling of carbon steel are demonstrated.
6
Korecki, Casey L., Jeffrey J. MacLean, and James C. Iatridis. "Development of a System for Application of Dynamic Mechanical Compression on Intervertebral Discs in Organ Culture and Investigation of Load Magnitude Effects." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-176569.
Full textAbstract:
In vivo studies on the intervertebral disc (IVD) indicate that the magnitude, frequency, and duration of applied compression loading results in alterations in mRNA expression, composition, and annulus fibrosus structure [1]. In vivo models typically use small animal models or small sample sizes that make it difficult to evaluate multiple dependent variables on the same tissue. In this study, it was considered a priority to utilize a large animal model to investigate the effects of magnitude of compression loading on interacting dependent variable measurements of disc cell viability, biosynthesis, composition, structure, and biomechanics. A bovine IVD organ culture system was used because it provides control over mechanical and chemical boundary conditions while maintaining viable cells and normal cell-matrix interactions. To date, there are no studies investigating the response of the IVD in organ culture to dynamic mechanical loading.
7
Dodson, Reuben Blair, Paul J. Rozance, Kendall S. Hunter, and Virginia L. Ferguson. "Increased Stiffness of the Abdominal Aorta With Intrauterine Growth Restriction in the Near-Term Fetal Sheep." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80634.
Full textAbstract:
Fetal intrauterine growth restriction (IUGR) results in increased placental resistance to blood flow, fetal hypertension and increased pulsatility [1]. These hemodynamic changes have been shown to lead to vascular remodeling in adolescents and adults [2, 3] but have received little study of its effect during this critical period of vascular formation. Epidemiological studies link IUGR to cardiovascular disease in adulthood [4], but the reason for this is not clearly understood. Here, we examine a large elastic artery for developmental alterations under hypertensive conditions. We hypothesize that fetal hypertension induces abdominal aorta (AA) stiffening in the fetal ovine model of IUGR and that the increased systemic artery stiffness is due to altered extracellular matrix (ECM) composition and structural changes.
8
Sander, Edward A., Mohammad F. Hadi, and Victor H. Barocas. "Multiscale Mechanical Models for Understanding Microstructural Damage in Fibrous Tissues." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53781.
Full textAbstract:
The mechanical behavior of tissues is critically dependent on the organization and composition of the extracellular matrix (ECM). In many tissues, the primary load-bearing component is fibrillar collagen, which is arranged into larger fiber bundles or fibrous networks depending on the specific tissue. This microstructural arrangement distributes and accommodates tissue-level loading and allows the tissue to function mechanically. Consequently, when collagen fibers are damaged, either through injury or disease, the distribution of load within the tissue changes, which can alter cell activity, mechanical behavior, and tissue function. This damage process underlies many physical ailments, but it remains poorly understood in part because of the difficulty relating macroscopic load to microsctructural alterations. To understand better local fiber failure and accompanying global restructuring, we have incorporated fiber damage from excessive force into our multiscale-modeling framework [1,2].