Dissertations / Theses on the topic 'MATERN 5'
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Ferrari, Solimar. "Câncer na gestação: avaliação de depressão, ansiedade, autoestima e vínculo materno-fetal." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-07022019-150110/.
Full textIntroduction: Currently, it is estimated that one in every thousand pregnant women are suffering from cancer. The association of the diagnosis of cancer with that of pregnancy puts a woman in a vulnerable condition for the development of psychological disorders. Objective: This Doctoral thesis aimed to evaluate and verify the association between symptoms of depression, anxiety, self-esteem and maternal-fetal bond among pregnant women diagnosed with cancer and pregnant women without a cancer diagnosis. It also proposed to understand the discourse of the experience of the gestational period with and without the diagnosis of cancer. Method: A cross-sectional study was performed with 63 pregnant women diagnosed with cancer, assisted at the Clinic of Tumors in Pregnancy of a tertiary university hospital and 72 pregnant women without a cancer diagnosis, assisted at the Clinic of Low-risk Prenatal care of the same service. These scales were used: MFAS for maternal-fetal bonding, Hospital Anxiety and Depression (HAD), self-esteem sub-scale of Prenatal Psychosocial Profile (PPP) and a semi-structured interview that investigated issues related to pregnancy and illness due to cancer. The Mann-Whitney, Kruskal-Wallis, Dunn, Pearson\'s chi-square and Fisher\'s exact tests were used. The level of significance was 5%. The qualitative analysis was performed by means of the Content Analysis Technique. Results: In this study, the presence of depressive symptoms was found in 33.3% of pregnant women with cancer and in 18.1% pregnant women without cancer. It was observed that the pregnant women diagnosed with cancer when compared to pregnant women without a cancer diagnosis presented lower per capita income (p > .001), lower level of schooling (p=0.001); higher number of pregnancies (p < 0.001), lower paid job (p=0.015), higher prevalence of depression (p=0.041), anxiety (p=0.039) and lowered self-esteem (p < 0.001). In the analysis made through the combination of cancer diagnosis and depression, it was shown that anxiety was associated with depression and not with the diagnosis of cancer. Regarding the self-esteem, the combination of the groups showed that the lowering of self-esteem is related to the presence of cancer and not with depression. These categories were attributed to the qualitative results in both groups: Pregnancy discovery, Prenatal experience, Relationship with the fetus and Meaning of pregnancy. With respect to the interviews only with the pregnant women with cancer, the following categories were defined: How was the discovery of the disease, Cancer treatment experience, Adaptation to the illness, Beliefs about the relationship with the fetus, Cancer experience during pregnancy and Meanings attributed to cancer. Conclusion: This study showed significant differences between the presence of depressive symptomatology, anxiety and low self-esteem among pregnant women diagnosed with cancer when compared to those without the diagnosis. In the qualitative analysis, it was found that with regard to the relationship with the fetus the following categories were identified: Chatting, Good relationship, Fear, Joy, Miracle and Not related. Regarding the Cancer experience during pregnancy, the following categories were highlighted: Negative focus, Positive focus, Duality and Normal. About the meaning of pregnancy, the categories were: Positive focus, Responsibility and Cannot explain. In relation to the meaning attributed to cancer, the categories shown were: Death/suffering, Healing/treatment, Overcoming and Cause
Agustoni, Camila de Almeida. "Influência do polimorfismo do gene do CCR-5 na transmissão materno-infantil do HIV-1." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/22/22132/tde-28112011-081634/.
Full textThe main via of infection by Human Imunodeficiency Virus (HIV-1) in children is the maternal-infant transmission (MIT). Several factors can be associated to MIT of HIV- 1. It\'s believed that the homozygote individual to the allele CCR5-?32 are resistant to the infection of HIV-1. Considering that the role of the mechanisms involved are still controversial, specifically the one of polymorphism of genes associated to the infection of HIV-1, this study evaluates the influence of deletion of the gene CCR5 in the MIT of the infection by HIV-1. It has been evaluated 82 couples of mothers and children, being 56 couples in which haven\'t occurred MIT and 26 in which have occurred MIT of HIV-1. In the current casuistry, it hasn\'t been detected meaningful differences when compared the presence of deletion of the gene CCR5 in MIT, in mother and children\'s couples, but it has been observed that there is a predominance of the presence of deletion in the not infected children to the ones vertically infected. Related to the social-demographic data, the use of antiretroviral therapy in the gestation and labor was meaningfully associated to the protection of MIT of HIV-1 (p= 0,0001 e p= 0,014, respectively). Therefore, the promotion of interventions that reduce the maternal viral load are fundamental for the reduction of MIT of HIV-1. There are several strategies to prevent the MIT, thus, children are still infected, becoming evident that there is still a wide challenge of its prevention. In this context, the nursing can contribute with actions that involve the prenatal, labor and puerperium, advising about the realization of the test of anti-HIV, the usage of antiretrovials, promotion and support of ideal practices of infant nourishment.
Dias, João Félix. "Colonização por estreptococo do grupo B em gestantes em Cuiabá." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/5/5141/tde-29102014-154314/.
Full textPurpose: To determine the prevalence rate of maternal colonization by Group B Streptococcus in the population of pregnant women in the gestational age of 35 or more weeks, attending prenatal care in two hospitals (HUJM - Hospital Universitário Júlio Muller and Hospital Santa Helena), in the city of Cuiabá, Mato Grosso. Materials and methods: Between October 2011 and October 2013, 258 pregnant women were assessed in HUJM and Hospital Santa Helena. After agreeing and signing the FCCT (Free and clarified Consent Term), those pregnant women of 35 weeks or more, who had not undergone gynecological examination, who were not on antibiotics and who also met the inclusion criteria, were subjected to vaginal and rectal swab collection, according to the established protocol. Stowed in Stuart transport medium and cultivated in IGBL biphasic Granada Broth in the laboratory. After 24 hours, samples with orange or reddish colors were considered positive, otherwise, new evaluation with a 48-hour culture was done. Data were submitted to statistical analysis, using OMS\' EPI-Info. The results: From the 258 given samples, 13.21% were positive for EGB, CI (95%) from 9.70% to 18.21%. Evaluation stratified by gestational age was predominant in pregnant women of 36 weeks with 35% positivity rate, 10.87% of pregnant women of 37 weeks and 5.88% of women of 35 weeks. During preterm labor 33.33% and in premature rupture of membranes, 28.57% cases were positive for GBS. Other analyzed parameters showed no significant statistically. Conclusion: The overall prevalence rate of GBS colonization was estimated at 13.95%, being higher in the gestational age of 36 weeks, with a rate of 35%. The present work should change public health policies in the city of Cuiabá
Macedo, Alessandra Regina Vieira Caetano de. "O desenvolvimento das habilidades de alimentação do bebê no primeiro ano de vida: uma perspectiva fonoaudiológica de promoção de saúde." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/5/5137/tde-10092012-151808/.
Full textObjectives: Investigate the effects of speech therapy in the development of feeding skills of the baby in the first year of life Methods: A prospective cohort study between April 2010 and May 2011 whit mother / baby binomial in a maternity hospital in the southern area of São Paulo and followed during 12 months. The study group consisted of newborns with 24 to 48 hours of life, children of primigravid mothers older than 18 years of age, wich had a score 11 according to the Oral-Motor in Nursery Assessment Scale undergoing speech therapy. The control group was obtained from babies born at the same hospital, with Apgar 9 and > 2,500 g, from mothers with similar characteristics who were contacted at 12 months. Results: The prevalence of weaning was similar in both groups, however breastfeeding presented Md of 7m and 5m in the study and control groups respectively (p = 0.04). The introduction of solid consistency food was at 7.8 m and 9.6 m (p <0.01). The glass transition were used by 92.9% and 70.2% (p = 0.01) and straws by 59.5% and 27.7% (p = 0.003). The prevalence of pacifier use was 54.0% and 27.7% (p = 0.01) at 12 months. Conclusions: The study group, compared to the control, presented: improvement in the performance of breastfeeding at 2 months, later weaning, reducing time for introduction of solid consistency food, wider use of utensils and lower prevalence of pacifier use at 12m
Fakhri, Nansi. "Microwave-Assisted Conversion of Sucrose into 5-Hydroxymethylfurfural over Acidic Nanoporous Materials." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/33360.
Full textSchupp, Tânia Regina. "Gravidez após os 40 anos de idade: análise dos fatores prognósticos para resultados maternos e perinatais diversos." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-03052007-142303/.
Full textMany women are delaying childbearing until the fourth or fifth decade in life, and it has become a common and worldwide phenomenon. The aim of this study is to evaluate pregnancy outcome in women of 40 or older who were care at our institution. During the period from July 1998 to July 2005 a total of 281 women with advanced maternal age presenting at Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo were studied. The incidence of gestational diabetes and preeclampsia was 14.6% e 19.2%, respectively. Seventeen women had miscarriage (6.0%) and four presented fetal death (1.4%). There were three infants with Down syndrome and six with other anomalies (detection rate of 88.9%). Women presenting preeclampsia were at higher risk for presenting low birthweight. Previous history of hypertension was not a risk factor for preeclampsia. Pregnant women with gestational diabetes or preeclampsia did not carry a higher risk for preterm delivery. Obesity was a significant prognostic factor for gestational diabetes. Nulliparous and single women had higher incidence of fetal anomalies and low Apgar score. Women with very advanced maternal age (>= 45 years old) had higher rate of fetal death and low Apgar score. Prenatal care devoted for women with advanced maternal age allows an early detection and treatment of adverse maternal-fetal outcomes.
Nascimento, Maria Beatriz Reinert do. "Caracteristícas do aleitamento materno no município de Joinville, SC." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/5/5141/tde-06112009-173310/.
Full textBreastfeeding is the safest and most natural form of feeding in infancy. Human milk contains a unique combination of nutrients, living cells and defense factors, and the short- and long-term nutritional, immunological, psychological and economic benefits of breastfeeding are well known and unquestionable. As a global public health policy, the World Health Organization recommends exclusive breastfeeding up to the sixth month of life. After that age, complementary foods should be introduced, but breastfeeding should continue until the child is two years or older. Public health policies, particularly those that promote infant nutrition, should be defined according to the health, healthcare and living conditions of a certain population. For this purpose, a rapid evaluation of breastfeeding rates is an important strategy. The general objective of this study was to determine the prevalence of breastfeeding among infants in the city of Joinville, SC. The specific objectives were: to characterize the kind of breastfeeding among infants younger than one year of age, to determine the prevalence of exclusive breastfeeding among infants younger than four and six months of age, to describe the frequency of pacifier and bottle use, to investigate the association between lack of exclusive breastfeeding for infants younger than 6 months and maternal, infant and healthcare variables. The data for this cross-sectional population survey were collected during the National Vaccination Campaign in August 2005 among the persons that accompanied 1470 infants to the vaccination clinics, using a questionnaire with closed questions, most of them about the infants feeding in the previous 24 hours. The infantile variables investigated were: age, gender, birthweight, infant birth order and use of pacifier. The maternal variables analysed were: age, maternal schooling and occupation. The healthcare variables studied were: mode of delivery, delivery in a Baby-Friendly Hospital, healthcare in public or private service, and preventive healthcare provided by pediatrician or other specialist. To evaluate possible risk factors of non-exclusive breastfeeding up to the sixth month, the Prevalence Ratio calculated by Poisson Regression was used as measure of association in bivariate and multivariate analysis. The results showed an overall rate of breastfeeding of 72.5%. The inquiry revealed that 84,1% of the infants younger than six months of age had been breastfed in the previous 24 hours, 43.7% of them exclusively. The inquiry revealed that 89.8% of the infants younger than four months of age had been breastfed in the previous 24 hours, 53.9% of them exclusively. Pacifiers and bottles were used by 51.3% and 51.1% of the infants. Factors significantly associated with the interruption of exclusive breastfeeding for infants up to six months were: age of 90 days or more, pacifier use and mother educational level of less than 12 years
Boreggio, Bianca Wierman. "A prematuridade no discurso materno: de que se trata?" Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5141/tde-20062016-144607/.
Full textWhat are the effects of the diagnosis of prematurity on mothers\' discourse and their repercussions on the mother-child relationship? Based on an issue that arose in the psychoanalytic experience in a pediatric hospital, this study aims to analyze the effects of the prematurity on the maternal speech by means of preliminary psychoanalytic interviews with mothers of premature children. This is a clinical qualitative research that proposes some articulation between clinical practice and theory based on the construction of four clinical cases justified by the theoretical reference of the psychoanalysis of Freud, Lacan and contemporary authors. If, in the social imagery, prematurity is associated with difficulties in various contexts of life, the analysis of each case shows that this diagnosis may or may not be triggered by the subject towards those significant ones who label them in such a defining form. In this sense, prematurity moves away from the place determinant of something that always labels and decides, into a place that can only be heard about in oneto- one conversations. For the case studies, the mother-woman disintegration has been singled out as a central conceptual operator due to its prevalence in the speeches, in a theoretical route based on the history of maternal love, under the psychoanalytical examination of maternity from the perspective of female sexuality. Such considerations are based on the myth of Badinter\'s maternal love toward the equivalence of the son as a surrogate for the lack of phallus, in Freud, to the emphasis on the woman\'s desire in the mother, in Lacan. The discussion presents the different roles allocated to prematurity and the prevalence of deadlocks typical of the mother-woman conjunction and disjunction reflected on the mother-child relationship
Brito, Maria Haydée Augusto. "Modelos de assistência neonatal: comparação entre o método mãe-canguru e o método tradicional." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/5/5141/tde-14102008-153456/.
Full textVery low birthweight infants have achieved increasing survival rates over time. However, they still suffer from problems such as growth deficit, developmental delays, low exclusive breastfeeding prevalence and difficulties with the bond formation process. These problems result from birth circumstances, consequences of survival-necessary intensive care and peculiarities of traditional neonatal care, whose procedures impose a prolonged separation between mother and baby. Observation of aspects relative to these problems indicates that some of those difficulties might be lessened, if not altogether solved, by a neonatal care model that favors the mother-child interaction. Aiming to clarify this matter, a comparison of results obtained for seventy babies was carried out. Infants were divided in two groups, one treated by means of the Kangaroo Mother Method and the other by means of the Traditional Neonatal Care Method. A prospective cohort study was carried out which included two approaches. The first approach was an epidemiological analysis of objective data concerning comparable characteristics of the two groups, such as maternal characteristics, data about pregnancy, labor and birth, clinical evolution events, developmental and growth parameters and landmarks of the breastfeeding process. The second approach was a comprehensive study of subjective data by means of the Phenomenological Method. It was found that growth of studied children was consistently below intrauterine growth, the established ideal. Antropometrical measures were smaller for children in the Kangaroo Mother Method group than for those treated by means of the Traditional Method. No statistically meaningful differences were found concerning neurosocial development. The Kangaroo Mother Method was found to favor the practice of exclusive breastfeeding even after child discharge. Phenomenological comprehension and interpretation of oral accounts given by the mothers of studied infants about their experiences with their preterm children revealed the repercussions of this situation on maternal function and the resulting consequences to development and breastfeeding prevalence. The direct influence that the quality of interaction between mother and baby has on the experience of becoming a mother under such circumstances was thereby unveiled. Under this perspective, it was concluded that care given to very low birthweight infants requires, in addition to the employment of high technology, that the staying of mothers beside their infants be prioritized and that the neonatal care team be made able to handle mother and infant as a compound unit, as two components of a system that are distinct, yet not separate.
Nogueira, Priscila Seravalli Calmon. "Sobrecarga e restrição de cloreto de sódio durante a gestação: repercussão sobre a estrutura cardíaca e renal no neonato." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5148/tde-20052016-110245/.
Full textIntroduction: Several studies have shown several consequences on adult offspring due to alterations in maternal nutrition during pregnancy, such as: hypertension, heart diseases, insulin resistance, diabetes mellitus and kidney diseases. Nevertheless, few studies evaluated maternal nutritional alterations in neonates. Methods: Female Wistar rats where fed from day one of pregnancy until delivery with low- (LS - 0.15% NaCl), normal- (NS - 1.3% NaCl) or high- (HS - 8%NaCl) salt diet. During the first twenty-four hours after birth, newborn\'s (n=6- 8/group) kidneys and heart were collected to evaluate possible changes of their structure by stereology. The protein and the gene expression of the renin angiotensin system components were evaluated by indirect ELISA and by RTqPCR, respectively. Results: Birth weight was lower in male and female offspring of dams fed LS during pregnancy. No differences between groups (LS, NS and HS) were observed in total renal volume and its compartments (cortex, medulla and pelvis) and number of glomeruli. The number of glomeruli was higher in female when compared to male newborns in the three experimental groups. The transverse diameter of the nuclei of the cardiomyocytes was higher in HS in both left and right ventricle vs. NS. The AT1 receptor protein expression was lower in kidneys of LS than in NS and HS male newborns. AT2 receptor protein expression was also lower in male LS than in NS. No differences in AT1 and AT2 receptors protein expression in female newborn\'s kidneys were found. Conclusion: The present study shows changes in cardiac structure male but not of female neonates induced salt overload during pregnancy. The alterations observed in AT1 and AT2 expression in kidneys of neonates may be responsible for alteration in renal function
Stach, Sonia Christina Leme. "Fatores preditivos de morbimortalidade materna nos partos de gestações gemelares." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-12042013-101812/.
Full textThe optimal route of delivery of twin gestations is a matter of controversy.There is a lack of data in literature regarding maternal delivery complications in these pregnancies. The objective of this study is to examine maternal postpartum complications according to delivery mode in twin pregnancies and investigate associated factors. Methods: retrospective review of all twin pregnancies, with more than 26weeks gestational age, that delivered between 1993 and 2008 at Hospital das Clínicas, São Paulo University Medical School. Delivery mode subgroups were defined as: vaginal, elective and emergency cesarean sections. Pregnancies with conjoined twins and combined deliveries were not included in the analysis. Stepwise regression analysis was used to investigate significant predictors of maternal postpartum complications. Relative risks and 95% confidence intervals were calculated. Results: Ninety maternal pospartum complications were observed in 56/817 (6.9%) deliveries: 7/131 (5.3%) vaginal, 10/251 (4.0%) elective cesarean sections and 39/435 (9.0%) emergency cesareans (p=0.03). Maternal complications were significantly associated with high-risk pregnancies (r=0.16, p<0.001), gestational age at birth (r=-0.09, p=0.01), and mode of delivery (r=0.05, p=0.13). The best-fit formula was described by 0.286 + (0.018 * mode of delivery) - (0.008 * gestational age at delivery) + (0.104 * high-risk pregnancy) (r=0.20). Prediction of maternal complications according to gestational age at delivery demonstrated an ROC curve area of 0.61 (95% confidence interval CI= 0.51 0.71). The likelihood of complications was increased for deliveries before 32 weeks (RR= 1.86, 95%CI= 1.03 3.29), before 33 weeks (RR= 1.82, 95%CI= 1.06 3.08) and for high-risk pregnancies (RR= 3.29, 95%CI= 1.99 5.36). Occurrence of complications was significantly increased in emergency cesarean compared to elective sections (RR= 2.34, 95%CI= 1.21 4.57).Conclusion: Maternal postpartum complications in twin pregnancies are related to preexisting complications, earlier gestational age and emergency cesarean deliveries
Nobre, Érica Bezerra. "Estilo de vida materno e aspectos nutricionais do pré-escolar." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5141/tde-04112016-155123/.
Full textBACKGROUNG: Many of the health behaviors involved in the emergence of non - communicable chronic diseases are originated in childhood under their parents influence. The mother is the most involved person in education and on the child health care. Lifestyle (LS) is a social health determinant and never before was understood maternal LS on aspects of childhood nutrition. OBJECTIVE: Verify the association on maternal behavior and non- behavioral LS with nutritional aspects in preschool. METHODS: From January 2010 to December 2010, it was performed a cross sectional study with 255 of preschool mothers peers resident on five different sub-districts in São Paulo Southwest. A stratified random sample was selected on two layers, being first the drawn schools and then, the children. From the mother, was caught the age, economical status, education, marital status, behavioral and non- behavioral LS. From the child, the age, weight and height to nutritional status, waist circumference, sedentary behavior, food intake, through an alimentation frequency questionnaire to the studied age group were all taken information about. An extraction analysis factor was performed in order to common factors and principal components on non-behavioral LS and food frequency, respectively, with a subsequent group of mothers on the domain of LS and the children on extracted factors. The association was calculated using the chi-square test and logistic regression. RESULTS: All the mothers were grouped into three clusters LS: socio conscious, self-actualization and consumeristic. The children were grouped into two feeding clusters: minimally and upper processed. Children with minimally processed food were born from mothers with more socio conscious non- behavioral LS, while children with upper processed food were born from mothers with more consumeristic non-behavioral LS. No other association was found between the nutritional preschool characteristics and the kinds of behavioral maternal LS. Not eutrophic and central adiposity present, children had 99% and 92% higher chance, respectively, to be children from mothers with a high score in the modern domain. Children with sedentary behavior and upper processed alimentation had 113% and 84% higher chance, respectively, to be children from mothers belonging to the consumeristic cluster. CONCLUSION: Non- behavioral maternal LS is associated to nutritional preschool characteristics being the mothers living a consumeristic lifestyle tending to have negative influences on child nutrition
Petrokas, Rejane Cristina. "A experiência materna no cotidiano de cuidados dos bebês de risco." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5170/tde-23042018-114527/.
Full textThis research aimed to know the maternal experience in the daily care of babies at risk at home, considering that a good care is determinant for child development. Thematic oral histories were carried out with three mothers of babies attended in a rehabilitation nucleus of the periphery of the east zone of São Paulo, selected by convenience. The interviews were recorded, transcribed, textualized and transcreated and later analyzed according to the method of critical hermeneutics. By means of thematic analysis, two categories were identified as a result: Becoming the mother of a baby at risk amidst the hardships of specialized care and The daily care of a baby at risk, each subdivided into four themes. The birth of the babies was accompanied by the news of their risk condition and the need for hospitalization, which caused suffering for the women. Interaction with at-risk babies did not develop spontaneously, which has impacted the process of becoming a mother. The period of the hospitalization of the babies was experienced by the mothers as an emptiness, making them to invest their strength in the babies\' discharge, to give continuity to life and motherhood. The women assumed the role of supporting their babies during the hospitalization period and began to get information about the care involved, also living an expectation of discharge. The arrival of the babies at home after hospital discharge was set up as a time when mothers assumed almost exclusively the role of caregiver, dealing with the instability of the baby\'s health condition. The inefficiency of the assistance network made this experience solitary, in the face of the discontinuity of care offered. Even with the feeling of insecurity, the mothers took on the routine care, the specialized procedures, and the out-patients follow-up of the babies. With the precarious supply of programs and policies that could ensure the continuity of healthcare, the mothers undertook a personal construction of a support network. The investigation of the diagnosis of the babies constituted a long process, with examinations and referrals in various health and rehabilitation services. The concern for the future of the daughters, the care of themselves and the personal projects began to be configured as themes for the women. With many tasks to accomplish and with limited time to take care of themselves, the women experienced physical and emotional exhaustion resultant of the care required by their babies, but in general they also referred the experience as pleasant, intense, and lived with great affection and interest. The fact that the participants were all primiparous contributed to the understanding of this experience of experiencing motherhood for the first time under the condition of becoming a mother of a baby at risk. However, other studies are necessary to understand the differences of experiences regarding mothers who had other children previously
Carvalho, Mariana Azevedo. "Efeitos da exposição materna à poluição na biometria e hemodinâmica fetais." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-27102015-121425/.
Full textBackground: Air pollution may influence fetal growth and placental flow according to trimester-specific exposure. Objectives: To determine the influence of maternal air pollution exposure during each trimester of pregnancy on fetal growth and fetoplacental hemodynamics. Methods: ProcriAR, a prospective cohort study of 386 pregnant women, was conducted in the city of São Paulo. Nitrogen dioxide (NO2) and ozone (O3) were measured during each trimester using passive personal monitors. In trimester 3, we evaluated the biparietal diameter, head circumference, abdominal circumference, femur length, fetal weight, amniotic fluid index and Doppler velocimetry data of the umbilical, middle cerebral and uterine arteries. Multivariate analysis was performed, controlling for maternal age at conception, body mass index, parity, smoking, alcohol consumption, race, highest education level completed, and marital status and the fetus\'s gestational age and sex. Results: Reduced head circumference was associated with O3 exposure in trimester 1 (p = 0.012; beta = -0.005; 95% confidence interval (CI), -0.008, -0.001), and increased head circumference was associated with NO2 exposure in trimester 1 (p = 0.033; beta = 2.5 x 10-4; 95% CI, 2 x 10-5, 4.8 x 10-4). Exposure to O3 during the second and third trimesters was associated with higher (p = 0.006; beta = 0.018; 95% CI, 0.005, 0.030) and lower (p = 0.004; beta = -0.022; 95% CI, -0.037, -0.007) umbilical artery pulsatility values, respectively. Conclusion: Our results suggest that in the environment of São Paulo, O3 may interfere with fetal growth and vascular resistance
Brasil, Tatiana Braga. "Transferência transplacentária de anticorpos anti-Streptococcus B nos recém-nascidos de termo e pré-termo." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/5/5141/tde-25082008-152728/.
Full textGroup B Streptococcus (GBS) is one of the leading causes of infections in mothers and newborn babies, and it is responsible for high mortality rates. The purpose of this study was to evaluate the transplacental transfer of anti-Streptococcus B antibodies and immunoglobulin G in term and preterm newborns and compare the serum levels between these two groups. A transversal study was conducted with 44 newborns (18 preterm and 26 term infants) admitted to the Nursery next to FMUSP Hospital das Clínicas Maternity in the period of December 2006 to July 2007. After they gave their informed consent, blood and umbilical cord samples were collected from the mothers and from their respective newborn babies. Total IgG measurements were performed using nephelometry and the presence of antibodies anti-GBS was evaluated by the immunoenzimatic test (ELISA). In both groups of mothers (16 preterm`s mothers and 26 term`s mothers) the serum levels of anti-Streptococcus B antibodies were similar and there was no statistical significance between them. The mean serum levels of anti-GBS antibodies in mothers was 1697,98, ranging from 456 to 5200 (in titles). The mean serum levels of anti-GBS antibodies in mothers of preterm babies was 1570,72, ranging from 588 to 3829 (in titles), while in term`s mothers the mean level was 1786,08, ranging from 456 to 5200. Anti-Streptococcus B antibodies in the newborns demonstrated significantly lower levels in preterm newborn compared to the levels of the term newborns. The mean serum levels of anti-GBS antibodies in preterm newborns was 1059,22, ranging from 416 to 3924 (in titles), while in term newborns the mean level was 2025,50, ranging from 542 to 5476. There was a positive correlation between the levels of immunoglobulin G and anti-Streptococcus B antibodies and the gestational age which shows the correlation between prematurity and low levels of anti-Streptococcus B antibodies. The association between gestational age less than 37 weeks and reduction of anti-GBS antibody levels corroborates with the fact that preterm neonates are more vulnerable to the infection by this bacteria. The authors have come to the conclusion that transplacental transfer of immunoglobulin G and anti-Streptococcus B antibodies have been proved in term and preterm newborns. The transfer of immunoglobulin and antibodies was less effective in preterm newborns, whose serum levels were significantly lower compared to the levels of their mothers and the term newborns. Term newborns showed levels of anti-Streptococcus B antibodies similar to their mothers due to the increase of transplacental transfer of antibodies during the end of gestation. The positive correlation between the levels of immunoglobulin G and anti-Streptococcus B antibodies with gestational age, proves the importance of prematurity as a determining factor of the low serum concentrations in the components of this newborn\'s immunological repertoire. There was no significant difference between the levels of anti-Streptococcus B antibodies in mothers of term and preterm newborns.
Ziza, Karen Nogueira Chinoca. "Determinação do genótipo RHD fetal no plasma materno: acurácia do teste semiautomatizado." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-03022016-093418/.
Full textBACKGROUND: Fetal RHD genotype determination in maternal plasma is a noninvasive prenatal diagnostic test performed in RhD negative pregnant women at risk of alloimmunization and/or Hemolytic Disease of Fetus and Newborn. Currently, this test is routinely performed in many countries but not in Brazil. The Department of Obstetrics at Hospital das Clínicas, São Paulo University Medical School provides tertiary antenatal care for RhD negative pregnant women including anti-D immunoglobulin administration, antibody levels monitoring and intrauterine treatment if necessary. AIMS: To validate the accuracy of a semi-automated test for fetal RHD genotype determination in maternal plasma. METHODS: Two-hundred and twenty blood samples were prospectively collected between 8 and 28 weeks of gestational age. Plasma processing was performed within 2 hours after blood collection, and nucleic acids were extracted from 1mL aliquots with an automated extraction platform (MagNA Pure Compact Roche) and the Large Volume kit. RHD gene exons 5 and 7 were amplified with real-time PCR (Step One Plus - Applied Biosystems) using the SAFE group protocol. RESULTS: Thirty-five samples were excluded due to pre-analytical problems, miscarriage and missing follow-up. In the remaining 185 samples, 130 (70.2%) were genotyped as RhD+ and 55 (29.8%) RhD-. Comparison with umbilical cord blood group phenotype showed 100% concordance. Seven samples showed amplification for exon 7 only. These were further investigated with conventional and real-time PCR with an specific protocol for RHD? pseudogene: 5 were positive and 2, negative. In these 7 cases, maternal buffy-coat DNA analysis also confirmed that 5 women were RHD?. In the remaining 2 cases, a multiplex protocol directed at RHD gene exons 3-9 confirmed that both mothers were truly RhD negative so exon 7 signal comes from the fetuses, further found to harbor D variants. CONCLUSION: The present study demonstrates that fetal RHD determination in maternal plasma is a fast, easy-to-perform and reproducible technique with high accuracy in our population. Moreover, it helps in the identification of possible RHD variants in our population
Debout, Frédérique. "Le soin, du maternage au travail maternel : contribution de la psychodynamique du travail à la psychopathologie des psychoses dissociatives chez l’adulte." Thesis, Paris, CNAM, 2016. http://www.theses.fr/2016CNAM1055/document.
Full textFrom her clinical experience in a therapeutic foster care unit for psychotic adults, the author returns to the clinic and the theory of dissociative psychosis, not from the perspective of the theory of mental illness and general psychopathology (as in psychoanalysis, phenomenology or organo-dynamism), but rather from the "work" and "living work" of those who care for these patients.If one starts from the practical analysis of treatment (Therapeutic Foster Care) with psychotic patients and their clinical characterization, one arrives at a renewed understanding of dissociative psychosis.These theoretical assumptions then allow the author to propose a new anthropology of the family and mother, rooted in theoretical contributions from the psychodynamics of work
Tognini, Silvana. "Tendência da mortalidade materna na região do Grande ABC Paulista de 1997 a 2011." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/5/5165/tde-23102014-150505/.
Full textIntroduction: Maternal mortality is one of the best indicators of socioeconomic development of a country. Brazil has implemented public policies to reduce maternal mortality by 2015. The Grande ABC Paulista region in Brazil shows great socioeconomic heterogeneity among its municipalities, which can reflect the country social inequality, however presenting dimensions that allow greater control of mortality data. Objective: To evaluate the trend of maternal mortality in the Grande ABC Paulista region in the period of 1997-2011. Methodology: Ecological time series, where data was obtained from the database of the Information Technology Department of the Public Health Care System (DATASUS) of the Health Ministry of Brazil (MS). The data was transformed into direct maternal mortality indices (DMMI), stratified by municipalities, Human Development Indices (HDI), causes of maternal death according to the International Classification of Diseases (ICD-10), period and local of maternal death, socio-demographic parameters. Data were submitted to comparison tests (Mann-Whitney U test, Kruskal-Wallis test, followed by Dunn\'s multiple comparisons test) and association tests (linear regression) when applied and a significance of 5%. Results: The DMMI predominated in single women, aged 20-34 years old, white, 4 to 7 school age, in-hospital, postpartum, by bleeding / thrombosis / embolism and eclampsia. There was no difference in DMMI when comparing by HDI group. The Municipality of Rio Grande da Serra reached high DMMI values in the most of the analyzed covariates. São Caetano do Sul presented the lowest DMMI values and was the only municipality which presented decrement in the DMMI during the 15 years of the studied period (beta = - 0.67/year, p=0.03) and a trend in this millennium (2000-2011, beta- 0.55/year, p=0.07) with an estimated fall of 65.61% by 2015. The sum of not investigated, not applied and files without investigation for any analyzed variable exceeded 50%. Conclusion: The DMMI in the Grande ABC Paulista showed high levels and downward trend in time. São Caetano do Sul was the sole municipality where the DMMR dropped in 15 years of study and presented a tendency to decrease in this millennium with an estimated fall of 65.1% by 2015
Mikami, Fernanda Cristina Ferreira. "Aleitamento materno em gêmeos: efeito do aconselhamento pré-natal e fatores associados ao desmame." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-02072018-154226/.
Full textOBJECTIVES: To describe the rates of initiation of breastfeeding in twins; to evaluate the effect of antenatal counseling on the rates of any and exclusive breastfeeding in twins; and to identify the factors associated with weaning and the factors cited by mothers of twins as a reason for breastfeeding cessation during the first six months of twin infants\' age. METHODS: A prospective trial in which one hundred and seventy-one women pregnant with twins were randomized into the prenatal counseling group or control group. Breastfeeding data were collected through personal interviews at three different times after birth: 30-40 days (Time 1), 90 days (Time 2) and 180 days (Time 3). RESULTS: The analysis comprised 68 women pregnant with twins in the prenatal counseling group and 60 in the control group. One hundred and twenty-three mothers of twins initiated breastfeeding (96.1%). There was no significant difference in the any breastfeeding rates between prenatal counseling group and control group in the analyzed times: Time 1 [odds ratio (OR) 1.87, 95% confidence intervals (CI) 0.71 - 4.95], Time 2 [OR 1.50, 95% CI (0.72 - 3.10)], Time 3 [OR 1.06, 95% CI (0.51 - 2.19)]. There was also no difference in the exclusive breastfeeding rates among the groups: Time 1 [OR 0.76, 95% CI (0.28 - 2.11)], Time 2 [OR 1.59, 95% CI (0.36 - 6.87)], Time 3 [OR 0.83, 95% CI (0.10 - 6.45)]. When considering the correlation between twins of the same mother, no difference was found between prenatal counseling group and control group, once the hazard ratio (HR) for weaning was 2,091 [95% CI (0.27 - 15.77)]. The analysis of the association of factors (maternal, obstetric, neonatal and related to the breastfeeding process) with weaning in twins during the first 180 days of life, evaluated by survival analysis methodologies, demonstrated a higher risk of breastfeeding cessation in the participants with: non-exclusive breastfeeding mode (p = 0.004, Cox proportional hazards regression model); absence of help during the lactation period (p = 0.001); difficulty in breastfeeding (p = 0.003); duration of previous breastfeeding less than 12 months (p = 0.001); and birth weight of the newborn of less than 2300g (p < 0.001). The main reasons for weaning cited by mothers of twins were insufficient breast milk supply, infant\'s behavior and returning to work. CONCLUSIONS: In twins, prenatal counseling did not significantly increase breastfeeding rates. The main factors associated with weaning in twin infants during the first 180 days of life were identified. This knowledge can help improve strategies to increase breastfeeding rates in twins
Arante, Flavia Oliveira. "Associação entre depressão puerperal e confiança materna em mulheres com histórico de depressão na gravidez." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/5/5137/tde-25102017-095819/.
Full textINTRODUCTION: Depressed mothers show reduced affective contact and difficulty in expressing positive feelings towards the baby. The objective of the present study is to evaluate the association of postpartum depression (PPD) and low maternal confidence (LMC) in women with a history of depression in the past pregnancy. METHODOLOGY: Transversal study, performed from June 2013 to May 2015, through data collected from the sixth to the ninth month after labor, from 344 puerperal women who had participated in a community trial (PROGRAVIDA). Maternal Confidence was assessed through the Maternal Confidence Questionnaire (MCQ) while socio-demographic, socioeconomic and health information on the participants was collected via structured questionnaire. PPD was evaluated through the \"Patient Health Questionnaire\" (PHQ-9). The prevalence ratio (PR), adjusted and non-adjusted, and the 95% CI were calculated using Poisson regression with robust variance. Three models were used: in the gross model (model 1), the PR between PPD and LMC was estimated, taking into account the randomization of participants in the community trial. The multivariate models estimated the PR between PPD and LMC adjusted for socio-demographic variables (education, monthly family income in tertiles, ethnicity and marital status) (model 2) and for maternal characteristics (mother\'s age, number of children and planned pregnancy) (model 3). The statistical analysis was performed with the STATA 12 software and the significance level was considered equal or lower than 5%. RESULTS: In the univariate analysis, the prevalence of LMC in women with moderate/severe depression was 35% higher in comparison to women without depression. Women with three or more children presented a lower prevalence of LMC in comparison to women with only one child (PR: 0.76, CI 95% 0.58:0.99). In the multivariate analysis, the association between LMC and PPD in its moderate/severe form remained after adjustment for possible confounding variables (socioeconomic variables and maternal characteristics). The estimation of the gross association between LMC and moderate/severe depression did not significantly change after the adjustments, evidencing that puerperal women with moderate/severe depression presented an increase of 42% in the risk of LMC (PR 1.42, IC 95% 1.14:1.77). DISCUSSION: In the present study, women with moderate/severe depressive symptoms showed increased risk of LMC in comparison to women without depressive symptoms. On the other hand, LMC was not associated to PDD in its minor form. These results corroborate evidence in the literature which state that PPD can disturb the expression of confidence and maternal care practices. The results reinforce the importance of the evaluation of maternal trust feeling in the first year of the child\'s life, particularly for women with more severe forms of depression
Souza, Susana Silva de. "UM ESTUDO SOBRE O PROCESSO DE SUBSTITUIÇÃO DE SEGMENTOS CONSONANTAIS NA AQUISIÇÃO DA FONOLOGIA DO PORTUGUÊS COMO LÍNGUA MATERNA." Universidade Catolica de Pelotas, 2003. http://tede.ucpel.edu.br:8080/jspui/handle/tede/5.
Full textO presente trabalho descreve as substituições consonantais presentes na fala de quarenta e oito crianças, divididas em oito faixas etárias, com idade entre 1:9 a 2:9, à luz da Teoria Autossegmental proposta por Clements (1985, 1989) e Clements e Hume (1995). Os dados utilizados são pertencentes ao banco de dados AQUIFONO, existente no curso de Pós-Graduação em Letras da UCPEL e no curso de Pós Graduação em Letras da PUCRS. Os resultados deste estudo permitem afirmar que há dois tipos de substituições: a) verdadeiras substituições quando o segmento que sofre a substituição já integra o sistema fonológico da criança, ou seja, quando a criança já tem conhecimento fonológico do segmento não empregado; nesse caso, considera-se que há uma troca de traços ; b) falsas substituições quando o segmento que sofre a substituição não faz parte do sistema fonológico da criança, ou seja, quando a criança não tem conhecimento fonológico do segmento-alvo. Embora cada tipo de substituição implique diferença quanto à representação fonológica de consoantes da língua, o resultado, nos dois casos, é o emprego de outro segmento em lugar do segmento-alvo, durante o processo de aquisição da fonologia.
Fernandes, Alessandra Fernandez. "Valvopatia mitral em gestantes: repercusões maternas e perinatais." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-27052010-164816/.
Full textPURPOSE: To evaluate the maternal (clinical e obstetrical) and perinatal events related to the predominant valvar lesion in pregnant women with mitral valve disease. This is a Observational and retrospective study of 117 pregnancies in 111 patients with mitral disease, followed in a single tertiary center from January 2004 until August 2008. Clinical and obstetrical data were reviewed and analyzed according to the main type of valvar lesion (stenosis or insufficiency). The statistical analysis of the results was performed by chi-square test, Fishers exact test, and Mann-Whitney test. Among the 117 pregnancies (and neonates), there were 71 cases of predominant mitral regurgitation (MR group) and 46 with predominant mitral stenosis. The MS group presented more severe heart failure symptoms (functional class III and IV) during pregnancy, received more cardiovascular drugs and needed more hospital admissions due to cardiac reasons . Concerning perinatal events, MS presented higher rates of cesarean sections, smaller birthweight and higher incidence of SGA (small for gestational age, babies. Nevertheless, the predominant valvar lesion was not significantly related to other clinical co-morbidities, obstetrical or perinatal complications. Mitral valve disease in pregnancy is related to clinical and perinatal events, especially in patients with predominant mitral stenosis
Neves, Itamara Lucia Itagiba. "Monitorização materno-fetal da portadora de doença valvar reumática durante procedimento odontológico sob anestesia local." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/5/5131/tde-18042007-090959/.
Full textDuring pregnancy, the organic systems of a woman are subjected to physiological modifications consequential to hormonal, anatomic and metabolical alterations. The most significant modification in the circulatory system is an increased cardiac output from the first three months of gestation. Women with heart disease may present with severe complications during the gestational period, because of inappropriate adaptation of her body to this hemodynamic overload, even those patients who are thought to have an appropriate functional capacity during early pregnancy. There are scant studies in the literature on the effects of local anesthetics, with and without vasoconstrictor, used in dental procedures on the cardiovascular variables of pregnant women with valvar disease, as well as on their concepti. Driven by this shortage, we decided to have this subject studied, by assessing and analyzing cardiotachographic parameters, such as heart rate, fetal motility and uterine contractions, in addition to blood pressure and electrocardiographic variables, in pregnant women with rheumatic valvar disease who undergo local anesthesia with lidocaine, with and without vasoconstrictor, during restorative dental procedure. For this, 31 rheumatic heart disease patients who were in their 28th to 37th week of gestation, had 24-hour ambulatory monitoring of their blood pressure (BP) and Holter electrocardiography (Holter-ECG), and cardiotocography (CTG), performed during: (1) baseline - 60 minutes before the procedure for BP and Holter- ECG monitoring, and 20 minutes before the procedure for CTG; (2) procedure - 56±15.5 minutes (mean±SD); (3) post-procedure - 20 minutes; and (4) mean 24-hour heart rate and extrasystoles measurement, and mean wake and sleeping periods BP monitoring. Variation of the above variables was analyzed in two groups, one with infusion of a 2% solution of lidocaine with vasoconstrictor, and the other with infusion of a 2% solution of lidocaine with epinephrine 1:100.000. The maternal heart rate values obtained during the procedure showed a significant reduction only in comparison with the other time periods (P<0.001). The comparison of the two groups did not reveal any significant difference (P>0.05). Cardiac arrhythmia was detected in 9 (29.0%) patients, 7 of them (41.8%) from the group who received anesthetics with epinephrine. Maternal blood pressure did not show any significant difference neither between time periods, nor between groups (P>0.05). The same occurred in the comparative analysis of the fetal parameters obtained during CTG -number of contractions, level and variability from baseline, number of fetal heart rate accelerations and fetal reactivity pattern. Our conclusion was that the use of 2% solution of lidocaine in association with epinephrine proved safe during dental procedure in pregnant women with rheumatic valvar cardiopathy.
Bio, Eliane Rodrigues. "Intervenção fisioterapêutica na assistência ao trabalho de parto." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-12022008-141747/.
Full textObstetrics intervention during labor involves a continuous up date on childbirth safety. Thus, vertical positions and free movements of woman, have been rediscovered as an efficient practice, to make easy the evolution of labor. Parallelly, there is a worldwide opinion supporting natural childbirth, despite the high scores of cesarean section in our country. This is the argument of physiotherapy intervention during labor for evaluate the influence of the maternal mobility on the progression of the active phase of labor, on the evolution of cervical dilatation and to facilitate the vaginal delivery. A prospective clinical trial was conducted through comparative analysis among a treatment group and a control group, in the Obstetric Center of the Hospital Universitário da Universidade de São Paulo. The inclusion criteria were: primigravidae with spontaneous labor with two uterine contractions every ten minutes and 3 or 4 cm of cervical dilatation; with 37 to 42 weeks of pregnancy; with a single fetus on cephalic presentation, besides the agreement to sign the free and informed consent term. Patients with clinical affections were excluded. Patients were assisted by the same physiotherapist during the whole active phase and encouraged to stay in vertical positions and to move in coordenation and specially pelvic mobility. Control group had an obstetric support without the presence of the physiotherapist and it was selected retrospectively, according to the same inclusion and exclusion criteria. 132 primigravidae were accompained: 70 in the treatment group and 62 in the control group. In the treatment group, 62 (89%) evolved to vaginal delivery and eight (11%) evolved to cesarean section. Among the patients who evolved to vaginal delivery, 50 didn\'t use ocitocina and the mean of active phase was 5h16min, and in the control group the mean was 8h28min (p<0,001); none of the patients used analgesics during the active phase, but in the control group 62% of the patients needed farmacos (p<0,001); as far as anesthesia for delivery is concearned, in the treatment group 12% didn\'t use any, 76% used anesthesia between 9 and10cm of dilatation; in the control group, all the patients used some kind of anesthesia and 40% of them did it between 7 and 8cm of dilatation (p<0,001). The 12 patients who evolved to vaginal delivery with ocitocina during the active phase, due to an uterine hipoactivity, had a mean of 7h duration active phase and the control group, 11h (p=0,059); the treatment group started later with the ocitocina and for a short period of time (p<0,05); none of the patients used analgesics whereas in the control group 83% used farmacos for analgesia (p<0,001). It follows that the intervention in the osteo and muscular structure facilited the progression of active phase, the pelvic mobility promoted the evolution of dilatation and the conscious use of the body improved the vaginal delivery.
Bastos, Laura Caroline. "Estudo da associação entre estresse materno durante a gestação e o padrão de metilação em sangue de cordão umbilical." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/5/5142/tde-28032018-084201/.
Full textBACKGROUND: Exposure to environmental factors and stress during the intrauterine period are associated with changes in the neurodevelopmental trajectory in a sex-dependent manner. Epigenetic mechanisms are involved in this association. OBJECTIVES: Analyze according to exposure to stress during pregnancy the impact of sex and DNA methylation alterations on umbilical cord blood in the anthropometric measurements of the neonate METHODS: A total of 94 pregnant women were recruited and questionnaires were used to measure stress exposure and risk factors during pregnancy. Umbilical cord blood collection followed a standardized protocol. In order to analyze the stress, the principal components analysis (PCA) of the exposure factors evaluated were: socioeconomic status, education, weight gain, pre-gravid body mass index, presence of psychiatric illness, and psychosocial stress during pregnancy. After the PCA we did group analysis by k-means. Methylation analyzes were performed using Illumina Infinium Human Methylation 450 (450K) BeadChip. The data were analyzed by the Minfi and ChAMP (Chip Analysis Methylation Pipeline) packages. From the differentially methylated positions (DMPs) was made analysis of enrichment of biological processes with the tool WebGestalt. To evaluate gender impact and methylation alterations in the neonatal anthropometric outcome we used multiple regression linear analysis models. RESULTS: The final cohort for the evaluation of stress was composed of 89 mother/newborn pairs, being 50 girls and 39 boys. The PCA showed that the first 3 components accounted for 60% of the variability of the sample. Being the first component (PC1) psychic stress, the second PC social stress and PC3 exposure to toxic. The biplot of the first two components suggested the separation of the mothers into two groups, confirmed by cluster analysis. Using the cutoff point of p-value < 0.01 and delta beta-value > 5%, we found 110 DMPs between the groups and restricting this value to p-value < 0.01 and delta beta-value > 10 % we found 13 DMPs. Using only children suitable for gestational age we did differential methylation analysis between genders. There were 426 DMPs found. None of the 13 DMPs found between the two groups belonged to the pool of DMPs between the sexes. In the multivariate linear regression model controlling for child sex and age of the mother we did not find any DMP associated with the anthropometric outcomes of the neonate. In group-stratified analysis the cg24702040 (MAP3K21), cg21550016 (PAX8) sites were statistically significant for abdominal perimeter and cg18706028 (CCKBR) and cg21550016 (PAX8) were statistically significant for head cephalic circumference for age. This study suggests that maternal stress independent of sex can affect fetal growth, mediated by epigenetic responses in genes related to stress response, negative regulation of the epidermal growth factor receptor signaling pathway, biogenesis of the synapse and apoptotic process
Costa, Verbenia Nunes. ""Cardiotocografia computadorizada em gestantes com diabetes mellitus: efeitos da glicemia capilar materna na freqüência cardíaca fetal"." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-21092006-111036/.
Full textThe effects of maternal glycemia over the of fetal heart rate (FHR) regulation appoint a controversial subject in the literature, mainly in pregnancies affected by diabetes mellitus. The objective of this research was to investigate the influence of maternal glycemia in the FHR indices analysed by computerized cardiotocography. Methods: Thirty nine patients with pre-gestational diabetes mellitus were examined prospectively in the Obstetrics Department of Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo- Brazil in a period of time between July of 2003 and February of 2005. The patients included had pre-gestational diabetes diagnosis, single pregnancy, gestational age between 36 and 40 weeks and absent of fetal malformations. Each patient were evaluated by computerized cardiotocography during 60 minutes, with analysis of these follow FHR parameters: basal FHR, time necessary to reach normality criteria, fetal movements rate, contraction peaks, accelerations and decelerations, episodes of high and low FHR variation, short-term FHR variation. The capillary glycemia were colleted immediately before the cardiotocography be performed, 30 and 60 minutes after the beginning of the exam. The glicemic mean level was used for analysis with the cardiotocografics results, with the cut values of 100 mg/dL and 120mg/dL. Results: From 39 patients studied, 25 (64,1%) presented glicemic mean ≥ to 100 mg/dL and 19 (48,7%) ≥ to 120 mg/dL. 1) The mean of FHR showed significant elevation in the groups with the glicemic mean ≥ to 100 mg/dL and to 120mg/dl (p<0,05); 2) There was significant positive correlation (p<0,05 and r=0,57) between the FHR and the mean glicemic; 3) There was significant negative correlation (p<0,05) between the number of transitory accelerations ≥ than 10bpm (r=-0,32) and ≥ than 15 bpm (r=-0,44) and the mean glicemic; 4) The short-term FHR variation presented significant association (p<0,05) with the mean glicemic ≥ 120mg/dL; 5) There was significant negative correlation (p<0,05) between short-term FHR variation (r=-0,47) and the mean glicemic. The others indices evaluated by computerized cardiotocography didnt exhibit significant difference with the mean glicemic. Conclusions: The maternal glicemic levels during computerized cardiotocography seem to have influence over these analised FHR parameters.
Oliveira, Manuela Correia de. "Doença respiratória baixa e aleitamento materno em crianças menores de 5 anos do município de Jaboatão dos Guararapes / PE : um estudo de prevalência." Universidade Federal de Pernambuco, 2012. https://repositorio.ufpe.br/handle/123456789/12912.
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Objetivo: estimar a associação entre doença respiratória baixa e aleitamento materno em crianças de 3 meses até 4 anos, no município de Jaboatão dos Guararapes, Pernambuco. Métodos: estudo de corte transversal. Foram aplicados 2 questionários padronizados às mães ou responsáveis pelas crianças nos domicílios por estagiários treinados. Nesse trabalho foram analisadas informações sobre as mães e as crianças: amamentação, dados demográficos e socioeconômicos, sobre o ambiente domiciliar, tabagismo, e história de asma dos pais. A variável de desfecho foi prevalência no período de 12 meses de Doença Respiratória recidivante com Sibilos (DRS) e pneumonia. Realizou-se exploração dos dados, análise bivariada, estratificada e análise multivariada com regressão logística não condicional, e usou-se a razão de chances como medida de associação. Resultados: Foram analisadas 781 crianças, com uma prevalência de DRS de 25,2% (n=197; IC 95% 22,2-28,3), e 4,9% (n=38; IC 95% 3,4-6,4) de pneumonia. A média de duração total do aleitamento materno (AM) foi 11,4 meses (DP ±11,3), mediana de 6 meses. Para AM exclusivo, a média de duração foi 2,9 meses (DP ±2,2), mediana de 3 meses. Não foi observada associação entre AM e DRS. Foi observada uma associação negativa entre AM total e pneumonia (OR ajustado de 0,30 (IC 95% 0,15-0,61)). Conclusão: o aleitamento materno conferiu proteção à infecção respiratória baixa (pneumonia), mas sem evidência para a doença respiratória recidivante com sibilos.
Osano, Bonface Ombaba. "Morbidity and mortality among 5-17 year old children admitted in five hospitals in Kenya in the year 2013." Master's thesis, University of Cape Town, 2015. http://hdl.handle.net/11427/16723.
Full textBackground: Global morbidity and mortality trends have changed over time and are expected to continue changing. Preventable diseases, such as those caused by infectious agents, still account for a large proportion of morbidity cases in Africa. With increased survival of children under five years old, there is likely to be a change in morbidity and mortality pattern s for children aged 6 - 18 years. However, there are few studies in Africa that explore the burden of disease (morbidity and mortality) and injuries in children above the age of five. This study aims to determine the morbidity and mortality patterns among children aged 5 - 17 years in six Kenyan hospitals in 2013. Methods: This study is designed as a retrospective review of patients' medical records. Data was collected from all patient records at Kisii Level 5 Hospital (KL5H), Naivasha County Referral Hospital, Karatina Hospital, Garissa Provincial General Hospital, Mbagathi District Hospital , and Gertrude ' s Children ' s Hospital in Kenya , of patients who presented from the 1st day of January to 31st December 2013. Data was analysed to provide descriptive statistics and Pearson's chi - square test and odds ratios were calculated to explore differences in morbidity and mortality rates between age categories, gender and hospitals. Results: 4 520 patient records were retrieved for patients who met the inclusion criteria. Among these admissions, 70% suffered from communicable diseases, maternal causes or nutritional diseases (32.3% were common infectious diseases , such as malaria and diarrhoea ; 14.9% were respiratory infections ; 24% were pregnancy related ), 33.1% suffered from non - communicable diseases , while 13% of the admissions had injuries (mainly from falls/trips and road traffic accidents), with motorcycles causing the majority (58%) of road traffic accidents . Injuries increased with age for males. The in-hospital mortality rate was 3.5%. Among deaths, 60% suffered from communicable diseases, maternal and nutritional causes; 41.3% suffered from non - communicable diseases and 11.9% had injuries. There were variations in admissions and deaths between the ages, gender s and hospitals. There were more female (57%) patients admitted but more male (57%) deaths. Conclusion: Infectious and maternal cause s are the biggest contributor to morbidity while infectious causes have the highest proportion of causes of death. There is a need to understand why the high proportion of females under 18 years of age is admitted for maternal al causes and to develop reproductive health services to better address the health care needs of adolescents on Kenya.
Garcia, Denise Maximo Lellis. "Percepção materna e autopercepção nutricional de crianças e adolescentes atendidos no pronto atendimento de um hospital escola." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/5/5141/tde-24022016-122335/.
Full textIntroduction: This study aimed to determine maternal perception regarding the nutritional status of her child and the self-nutritional perception status of children and adolescents. There is evidence that mothers have difficulty in properly recognizing the nutritional status of their children, especially overweight cases. Children and adolescents also do not accurately perceive their own nutritional status. Prevention of overweight and eating disorders requires early and adequate perception of these conditions. The perception failure of the actual nutritional status of children and adolescents by their mothers and themselves is a major barrier to seeking professional assistance. Few studies have addressed this issue in Brazil . Main Objectives: To determine the appropriateness of the recognition of nutritional status of children and adolescents by themselves and their primary caregivers. Secondary Objectives: To analyze factors affecting the perception of the nutritional status of children and adolescents by themselves and their caregivers. Method: A cross-sectional analytical study conducted in the emergency room of the University Hospital of the University of São Paulo from March 2009 to April 2010. We included 1,001 children aged 2-14 years and their primary caregiver. A questionnaire that evaluated self-nutritional perception of the child or adolescent and maternal perception about the nutritional status of her child through verbal descriptors was administered. The weight and height of children and their primary caregivers were measured. The correlation between the actual nutritional status of children and the classifications mentioned by the mother and by the child or adolescent were analyzed using the Kappa coefficient. Factors associated with incorrect self-perception and maternal perception of the nutritional status of children and adolescents were assessed by multivariate analysis. Results: The correlation between maternal perception and nutritional self-perception of children with the actual nutritional status of the child was poor (weighted Kappa, 0.236 and 0.295, respectively). The nutritional classification of the child was judged correctly by 50.9% of mothers. The child\'s gender (OR, 1.59 1; CI, 17-2.01; p = 0.008) and age (OR, 1.01; CI, 1.00-1.01; p < 0.001) influenced the mother\'s classification accuracy. Mothers who classified themselves as \"heavy weight\" were more accurate about the nutritional status of their children (OR, 1.54; CI, 1, 10-2.15; p = 0.011), whereas mothers of children with overweight (OR, 0,17; CI 0,11-0. 25; p < 0.001) and obesity (OR, 0.28; CI, 0.18 to 0.44; p < 0.001) had worse perception of the correct nutritional status of their child. Mothers underestimated the nutritional status of boys and overestimated that of girls. Mothers who were overweight (p = 0.025) or obese (p = 0.010) underestimated the nutritional status of their children more often, and mothers of children with overweight (p < 0.001) and obesity (p < 0.001) also underestimated the nutritional status of children more often. Self-nutritional perception was correct in 49% of children. Of those who were incorrect, the majority (58%) underestimated. The gender (OR, 1.60; CI, 1, 13-2.26; p < 0.007) and age (OR, 1.01; CI, 1.10-1.02; p < 0.001) of the children influenced their self-nutritional perception. Overweight children were less likely to properly perceive their actual nutritional status (OR, 0.38; CI, 0.23-0.63; p < 0.001). Girls tended to overestimate their own nutritional status, whereas boys tended to underestimate it (p = 0.027). Conclusion: The maternal perception of the nutritional status of the child and adolescent is often incorrect. Both mothers and children tend to over- and underestimate the nutritional status in girls and boys, respectively. These results show the importance of evaluating the nutritional perception of children and providing support to families for recognizing the actual nutritional status of their child and seeking an effective preventive action, since early detection is the first step toward preventing overweight or improving and preventing eating disorders
Martinez, Daniela Silva. "Investigação do comprimento telomérico em famílias com vários afetados pelo transtorno bipolar." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5142/tde-06042018-121637/.
Full textBACKGROUND: Bipolar Disorder (BD) is a debilitating and chronic mental illness. It is etiology and pathology are not completely known yet, despite the evidence of an important genetic component from family, twin and adoption studies. Recently, BD has been related to a process of accelerated aging, with some studies showing shortened leukocyte telomeres in this population. The purpose of the present study was to investigate the association between leucocyte telomere length (LTL) in BD patients compared with healthy relatives of 22 families with several affected members by this illness, besides associating clinical symptomatology and other covariates with this parameter. It was also examined the genetic and environmental influences on telomere length trait in these BD families, using a variance component approach, by estimating the heritability of this trait as well as covariate effects. METHODS: Telomere length (T) was estimated in a sample of 143 individuals, including 60 BD patients from 22 families, which was measured in relation to the single copy gene (S) - beta-globin gene, using a singleplex real time PCR (Polymerase Chain Reaction), providing a ratio of number of copies of T by S (T/S ratio). Taking in consideration the family structure, the statistical analysis was adjusted for the polygenic mixed model. RESULTS: The effect of BD illness in telomere length was small and we found no association between BD group and LTL (p > 0.05). However, LTL was associated with the variable suicidal ideation (p = 0.02) and interaction between suicidal ideation and course of disorder (p = 0.02). Association of LTL and maternal age and BD was also observed (p < 0.05). In addition, an important genetic component for telomere length was also observed (heritability = 0.68) in these families. CONCLUSIONS: The hypothesis of accelerated aging in BD, investigating the telomere length as one of its components, was not confirmed in our study. We found no difference between LTL and BD in our family group. However, using covariates that indicate severity of disease, both suicidal ideation and interaction between suicidal ideation and course of disorder were statistically significant with LTL, showing that shorter LTL was associated with worse clinical course (p < 0.05) and suicidal ideation (p < 0.05) in BD patients. Association of LTL with maternal age and BD (p < 0.05) suggests that advanced maternal age may not only be a marker of longevity, but also the BD phenotype may reinforce this condition. A high heritability for telomere length (0.68) also suggests an important genetic variability of this trait presented among those families. To our knowledge, this is the first study that found association between suicidal ideation, course of disorder, maternal age and LTL in families with several members affected by BD. Further investigations, including replication studies in other BD families, are needed to confirm these new findings
Moretti, Myla Emily. "Prospective follow-up of infants exposed to 5-aminosalicylic acid containing drugs through maternal milk." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0010/MQ40845.pdf.
Full textOliveira, Claudia de. "Influência da posição prona, em maca para gestantes, nos parâmetros hemodinâmicos materno-fetais e no conforto da gestante." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-24112015-094855/.
Full textIntroduction: Due to the increase of the abdominal volume, the prone position is a difficult and uncomfortable position for pregnant women. Hence, so far, it has not been tested if, in this position, a pregnant woman would have her maternal fetal hemodynamic parameters altered. Objectives: The objectives of this study were to analyze the influence of prone position in maternal-fetal hemodynamic parameters and the comfort of the pregnant woman on a prototype stretcher specially built for pregnant women. Method: A prospective, observational, crossover study with 30 pregnant women in antenatal segment, and 16 non pregnant women as a control group. The two groups were subdivided to take part in two types of randomized sequences of positions, investigating if the change in the order of the sequences would bring a significant alteration in the maternal fetal hemodynamic values. The positions used in this study were: prone, supine position, fowler position and left lateral. The following hemodynamic parameters were assessed: maternal heart rate, systolic blood pressure, diastolic blood pressure, oxygen saturation and respiratory rate and baseline and fetal variability. To the statistical analysis we used the non-parametric analysis for repeated measures and to verify if the position prior to the prone position would have any influence in it and variables of variation were created and compared to the Wilcoxon test. Results: Comparing the prone positions indexes to the other ones obtained, we observed that all the parameters were within the standards of normality and there was no interference in positions prior to the prone position in these values. The pregnant group showed means significantly higher than the ones of the non-pregnant women regarding the heart rate in sequence 1 (p < 0.004) and in sequence 2 (p < 0.001) and respiratory rate in sequence 1 (p= 0.041) and sequence 2 (p= 0.012). In the analysis of the pregnant group we observed that in prone position the systolic blood pressure and the diastolic blood pressure showed lower values than the other in both sequences. In the systolic blood pressure in the pregnant group sequence 1 the comparison of prone position with the fowler position (p < 0.001), with the supine position (p < 0.001) and with the left lateral (p < 0.001) in the pregnant group sequence 2 the comparison of the prone position with the fowler position (p < 0.001) and with the supine position (p= 0.013) it is observed a significant difference. In the diastolic blood pressure in comparison of the prone position in the pregnant group sequence 1 with the fowler position (p < 0.006), with supine position (p= 0.023) and with the left lateral (p= 0.017) and the pregnant group sequence 2 with the fowler position (p < 0.005) and with the supine position (p= 0.008) it is observed a significant difference. To the oxygen saturation in the pregnant group sequence 2 there was a significant difference when compared to the prone position with the fowler position (p= 0.021) and the prone position with the supine position (p= 0.003). In both sequences there were no significant differences in the fetal baseline between prone position with the left lateral. There were not observed any significant variations in the fetal variability in the sequences assessed. All the patients declared having felt comfortable during their stay in each one of the positions. Conclusion: In the prone positioning the maternal-fetal hemodynamic parameters were within the standards of normality and this position on the stretcher especially designed for pregnant women, considered as a safe and comfortable position
Faria, Camila Cristina Quinello Gomes de. "Aquisição passiva de anticorpos protetores reativos com Bordetella pertussis pelo recém-nascido via transferência placentária e aleitamento materno." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/5/5141/tde-20042010-100222/.
Full textPertussis is currently considered an important public health problem in developed countries. Although there is no evidence of an increase in the number of pertussis cases in our country, can not rule out the hypothesis of a future re-emergence of disease, as epidemiological data from some regions show an increase in incidence, indicating that probably there is a low report of new cases to the public health authorities. Most cases still occurs in infants under six months of age, i.e. children not fully immunized. Several works have demonstrated the acquisition of IgG antibodies reactive with Bordetella pertussis by the newborn through placental transfer, but by age of two months it was observed a substantial decay of titers these antibodies. In this case, another way to confer protection the neonate is through the transmission of IgA antibodies via breast-feeding, which could supply the lack of IgG antibodies until the vaccination schedule will be completed. The aims of this work were to analyze the passive transfer of IgG and IgA anti-B. pertussis antibodies to term newborns and to investigate the ability of these antibodies to neutralize the bacterial pathogenicity in an experimental model in vivo using mice intracerebrally challenged with viable B. pertussis. It was collected 40 paired samples of maternal blood, cord umbilical blood and colostrum. Equivalent titers of anti-pertussis IgG antibodies were demonstrated between maternal and cord serum samples (medians of 1:225 and 1:265, respectively) with transfer rate of 118%. It was observed variable specific IgA titers in maternal colostra with a median of 1:74. Immunoblotting performed with B. pertussis crude extract and Pools of maternal serum, cord serum and colostrum with high and low specific antibody titers revealed an identical recognition profile between paired maternal and newborn serum Pools. Colostrum Pools presented, in their recognition profile, different intensities that varied according to specific IgA antibody titers. In the intracerebral challenge with B. pertussis, although all maternal and cord serum and colostrum Pools presented a significant bacterial neutralizing ability when compared with positive control group, Pools with high antibody titers revealed higher neutralizing capacity. Serum and colostrum Pools absorbed with B. pertussis and, thus, without specific IgG and IgA antibodies, protected 30% of the animals tested and purified IgG antibodies, presenting a high anti-pertussis antibody titer (1:2,560), protected 65% of the mice. Our data confirmed the transfer of antibodies reactive with B. pertussis to the neonate via placenta and breast-feeding and their effectiveness in bacterial pathogenesis neutralization, which could protect infants against respiratory infections caused by Bordetella pertussis.
Rhoads, Jacqueline, and Jo-Ann Marrs. "Disorders Usually Presenting in Infancy or Early Childhood 0-5 Years Age." Digital Commons @ East Tennessee State University, 2010. https://dc.etsu.edu/etsu-works/7098.
Full textMaganha, Carlos Alberto. ""A relação entre o perfil glicêmico materno e o índice de líquido amniótico em gestações complicadas pelo diabetes mellitus"." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-13072006-084712/.
Full textTo examine the association between glycemic control and amniotic fluid volume sixty pregnancies with pre-existing diabetes were examined. Amniotic fluid index (AFI) was evaluated weekly after 27 weeks of gestation and self-monitoring blood glucose levels (expressed as mean blood glucose levels and percentage of abnormal values) were recorded the week before ultrasound examination. Six hundred fifty nine examinations were recorded and analysed by graphs and Spearman correlation test. There was no significant association between AFI and glycemic control
Ferreira, Josiane Sales Alves. "Condições de vulnerabilidade sociodemográfica e estresse psicossocial materno como marcadores de risco para morbidade e estado nutricional em lactentes." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5141/tde-23102018-121112/.
Full textIn Brazil, as in other countries, many are the external factors that are associated with the conditions of health and nutrition of the population. Among them, the focus of this study is the socio-demographic and maternal factors, more specifically the maternal psychosocial stress. There is evidence suggesting long term effects of maternal stress and early social conditions. The aim of this work was to study the association between socio-demographic / maternal psychosocial stress and infant hospitalization, nutrition from O to 12 months, among children who were born in conditions of high social vulnerability in the municipality of Sao Paulo, Brazil. It is a longitudinal epidemiological study, a population based birth cohort, with four moments of assessments: third trimester of pregnancy, second, sixth and twelfth months of life. Data on birth, feeding practices during the first year of life, socio-demographic factors and maternal mental disorders (both during pregnancy and postpartum) of 892 dyads mother-infant were collected. It was seen that substance use and anxiety were associated with inadequate feeding practices - less breastfeeding and earlier weaning. Maternal schooling was a good marker for bad feeding practices, as well as being a single mother. Domestic violence against the pregnant women was associated with hospitalization. In conclusion, maternal social stress and social vulnerability are markers of infant morbidity and nutrition
Leiba, Elka. "Maternal nonverbal behaviours and infant gaze during triadic play with toys at 5 and 12 months." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/MQ54278.pdf.
Full textCantin, Édith. "Étude des contributions environnementales et génétiques au langage maternel lors d'interactions mère-enfant à 5 mois." Thesis, Université Laval, 2010. http://www.theses.ulaval.ca/2010/27671/27671.pdf.
Full textPaiva, Letícia Vieira de. "Nutrição da gestante portadora de anemia falciforme, complicações maternas e resultados perinatais." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-06062016-112451/.
Full textThe prognosis of pregnancy is influenced by the mother\'s nutritional status. It is known that, from childhood, people with sickle cell disease have deficient growth. Little is known about the evolution of maternal nutritional status in sickle cell anemia. The objective was to analyze the nutritional status of pregnant women with sickle cell anemia, assessing their weight gain, maternal dietary intake, and adverse maternal and perinatal outcomes. Methods: A total of 26 pregnant women with sickle cell anemia SS and 23 SC, from the start of pre-natal to the postpartum period. It was used as a control group 63 pregnant women without comorbidities. The nutritional status of pregnant women was evaluated according to body mass index, prepregnancy and late pregnancy and maternal weight gain. Dietary intake was assessed by food frequency questionnaire in each quarter, characterizing the total energy, macronutrients and micronutrients intake. Maternal and perinatal complications were investigated. The significance level was 0.05 (alpha=5%). Results: The pre-pregnancy BMI was significantly lower in the SS group (median 20.3 kg/m2) compared to the SC group (22.7 kg/m2, p < 0.05) and control (23.2 kg/m2, p < 0.05). The low pre-pregnancy weight (BMI < 18.5 kg/m2) was significantly more frequent in the SS group (15.4%) when compared with the SC group (4.4%) and control (1.6%, p=0.009). At the end of pregnancy, the SS group had lower BMI (median 23.1 kg/m2) compared to the SC group (26.1 kg/m2, p < 0.05) and control (28.5 kg/m2, p < 0.05). Weight gain during pregnancy was lower in the SS group (median 8.0 kg) compared with the SC group (11.9 kg, p < 0.05) and control (13.7 kg, p < 0.05). The dietary intake analysis in the 2nd quarter showed that the SS and SC groups have a lower protein intake (median, 73 g/d and 69 g/d) compared to controls (96 g/d, p < 0.05); and calcium intake is lower in the SS group compared with controls (median, 410 vs. 748 g/d, p < 0.05). In the 3rd quarter, the protein intake was lower in the SS group compared with controls (median, 68 g/d vs. 93 g/d, p < 0.05); the vitamin A intake was lower in the SS group compared to controls (median, 447 vs. 940 mcg/d, p<0.05); the consumption of vitamin E was lower in the SS group (median, 6 mg/d) groups when compared to SC (10 mg/d) and control (7 mg/d, p < 0.05). The most frequent maternal complications were: a pain crisis, 58% in the SS group and 44% in SC (p=NS); urinary tract infection in 31% of SS and 17% of SC (p=NS); and pulmonary infection, 35% in the SS and 9% in the SC group (p = NS). There were significant differences in the diagnosis of fetal distress: SS (36%), SC (14%) and control (13%, p=0.032). Adverse perinatal outcomes were more common in SS and SC groups when compared to controls. Conclusions: The nutritional status of pregnant women with sickle cell disease SS is characterized by maternal malnutrition with low weight gain during pregnancy. Dietary intake of macronutrients demonstrates inadequate protein intake in the second and third quarters. Maternal complications and adverse perinatal outcomes are frequent events in pregnant women with sickle cell disease
Oliveira, André Luiz Malavasi Longo de. "Trombofilias maternas hereditárias com e sem tromboembolismo venoso: resultados maternos e neonatais." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-25082010-112901/.
Full textThe aim of this study was to evaluate differences in maternal and neonatal outcomes in pregnancies complicated by inherited thrombophilias between patients with and without venous thromboembolism. Despite increasing evidence in the literature indicating an association between inherited thrombophilias and adverse obstetric outcomes, doubts remain whether thrombophilic patients with venous thromboembolism present poorer maternal and neonatal outcomes than thrombophilic patients without venous thromboembolism. In this retrospective, observational and comparative study, 66 pregnant women with inherited thrombophilias, including 33 with venous thromboembolism and 36 without thromboembolism, were investigated. The main end-points analyzed were severe pre-eclampsia, placental abruption, fetal growth restriction, stillbirth, preterm delivery, and maternal hemorrhagic complications. The congenital thrombophilias included in this study were factor V Leiden (FVL), prothrombin G20210A mutation, C677T mutation in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, protein S deficiency, protein C deficiency, and antithrombin deficiency. The two groups were similar in terms of population characteristics. The frequency of maternal and fetal/neonatal complications was similar in the two groups: severe pre-eclampsia (P=0.097), placental abruption (P=0.478), fetal growth restriction (P=0.868), stillbirth (P=0.359), preterm delivery (P=0.441), and maternal hemorrhagic complications (P=0.478). This study concluded that venous thromboembolism in thrombophilic patients does not worsen maternal or neonatal outcomes when compared to thrombophilic patients without venous thromboembolism.
Fazio, Eliener de Souza. "Perfil nutricional de gestantes que receberam orientação dietética: avaliação do ganho ponderal materno total, tipo de parto e resultados perinatais." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-27092010-142844/.
Full textThis study was carried out at Clínica Obstétrica do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, with one hundred eighty-seven pregnant women without comorbidities. This study aimed to know the nutrition profile of pregnant women who received dietary counseling and to evaluate the maternal total weight gain, type of delivery and perinatal outcome. A retrospective and descriptive research was carried out through consultation of forms of dietary anamnesis, the clinical databases and medical records. The women were classified according to pre-gestational body mass index (BMI): 23 (12.2%) were underweight (BMI < 19.8 kg/m2), 84 (45%) normal weight (BMI 19.8 to 26.0 kg/m2), 37 (19.8%) overweight (BMI 26.1 to 29.0 kg/m2) and 43 (% 23) obese (BMI > 29.0 kg/m2). No difference was observed in energy consumption between the groups. The averages percentage of carbohydrates, protein and lipid intake were similar between groups. Regarding the profile of micronutrient intake, calcium intake, vitamin A and vitamin C was similar between groups; iron intake was higher in normal weight pregnant women compared to overweight and obese (p<0.001); folate intake was higher in normal weight pregnant women compared to obese (p=0.002); fiber intake was lower in underweight pregnant women compared to normal weight (p=0.042). Excessive weight gain (above the recommended) was significantly higher (p=0.009) in pregnant women with overweight and obesity, however the mean of total maternal weight gain was significantly lower in obese women (p<0.001). No difference was observed between the groups regarding gestational age at delivery and mode of delivery. The weight of newborns of underweight pregnant women had a mean significantly lower (p=0.005) compared to other groups. The overweight pregnant women had a higher percentage of newborns with more than 4000g (p=0.037) compared to other groups. The proportion of newborns large for gestational age was significantly higher (p=0.006) in pregnant women with overweight and obesity compared to other groups. The Apgar scores did not differ significantly between groups. Indication of cesarean for contracted pelvis was significantly more frequent in underweight pregnant women (p=0.006) when compared to other groups
Cintra, Mariana Vieira. "Prevalência de experiências psicóticas na gestação e fatores de risco associados em uma amostra comunitária." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5142/tde-17112016-163236/.
Full textThis research investigated the prevalence and construct validity of psychotic experiences (PEs) during pregnancy and the risk factors in a community sample in the city of São Paulo. Sociodemographic and environmental risk factors, psychiatric disorders, domestic violence, intellectual capacity and family history of psychiatric disorders in the present and throughout life were the investigated elements. Pregnancy and delivery outcomes were also evaluated. This is a prospective research, starting in the 3rd trimester of pregnancy. The evaluation interviews were conducted by trained psychologists. For the evaluation of PEs, the brief standardized diagnostic interview tool was used - Mini International Neuropsyquiatric Interview (M.I.N.I), validated for the Brazilian reality. For the sociodemographic risk factors, both socioeconomic questionnaire (SEQ) and population density (PD) were applied and the criterion of economic classification in Brazil (CECB) was used by the Brazilian Association of Research Companies (BARC) and World Health Organization - WHO for domestic violence. The intellectual capacity evaluation was carried out, using the Wechsler Intelligence Scale for Adults, third version (Waiss-III), and the family history of mental disorders was investigated through The Family History Screen (FHS). The results indicated a prevalence of 19.22% of PEs during pregnancy and sharing the risk factors present in schizophrenia, such as urbanicity, young pregnant women, use of drugs and alcohol, socioeconomically disadvantaged, low educational level, exposure to situations of violence, the presence of psychiatric disorders such as depression and anxiety, and family history of any psychiatric condition. This research, conducted in an urban area of the city of São Paulo, with high social vulnerability, indicates that the prevalence of PEs in pregnant women is high, affecting about 1 in 6 of them. The presence of PEs is strongly associated with general psychopathology and broad risk factors. In this sense, the presence of PEs may constitute an important risk factor to be evaluated in clinical environments during pregnancy. Future researches intending to look into its usefulness for indication of interventions are needed, as well as studies to search into the course of PEs after pregnancy and its association with health outcomes for women and their children
Chagas, Kélem de Nardi. ""Avaliação do gene estrutural da proteína de ligação à lectina (MBL) e sua relação com a transmissão materno-fetal do HIV"." Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/5/5144/tde-16112005-114946/.
Full textIt was evaluated the mbl2 gene expression in 79 children and their HIV positive mothers with the aim to evaluate its influence on mother-to-child HIV. The patients were divided in two groups: HIV positive children and their mothers (n=18) and HIV negative children and their mothers (n=61) were evaluated by CH50 and AP50 (hemolytic assays); levels and functional MBL and terminal complement cascade (ELISA) and mbl2 gene (PCR). The results didn't show significant difference amons serum levels, functional activities and MBL gene between the groups, excluding the influence in the mother-to child HIV transmission.
Saruga, Cláudia Alexandra Canaverde. "Hospital amigo dos bebés: desenvolvimento & implementação dos passos 4 e 5 no HESE - EPE." Master's thesis, Universidade de Évora, 2014. http://hdl.handle.net/10174/13003.
Full textLópez, Gabriel Rudy. "Determinación del polimorfismo C677T del gen de la 5-metilentetrahidrofolato reductasa en mujeres gestantes provenientes del Instituto Materno Perinatal San Bartolomé." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2015. https://hdl.handle.net/20.500.12672/8455.
Full textTesis
Hookenson, Kaia Vivian. "Programming of stress regulation in 5 - 7 year old children by maternal gestational mood and antidepressant use." Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/48579.
Full textMedicine, Faculty of
Obstetrics and Gynaecology, Department of
Graduate
Mioto, Verônica Carneiro Borges. "Avaliação da suficiência de iodo e sua relação com a função tireoidiana materna em gestantes provenientes da cidade de São Paulo, SP." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/5/5135/tde-16112017-092804/.
Full textThyroid dysfunction in pregnancy is associated with increased rate of obstetrical and neonatal adverse outcomes. Iodine deficiency continues to be a major cause of thyroid dysfunction. The state of São Paulo is considered a sufficient iodine region. However, pregnant women are considered a risk group for iodine deficiency due to an increased demand for production of thyroid hormones throughout pregnancy. This study aims to evaluate the iodine sufficiency of pregnant women in São Paulo and to correlate iodine concentrations with thyroid parameters in each trimester of gestation. Methods: A cross-sectional study was carried out with low-risk pregnant women in the three trimesters of gestation. We analyzed 251 women without history of thyroid disease, with negative antithyroid autoantibodies (anti TPO and anti TG) and who were not taking iodine supplementation. The urinary iodine concentration (UIC) was measured by the Sandell-Kolthoff digestion method in casual morning urine samples. Serum TSH, T4, T3, free T4 (FT4), free T3 (FT3), thyroglobulin (TG), TBG, anti-TPO, anti-TG, estradiol and hCG were measured by the electrochemiluminescence method. Thyroid ultrasound was performed with Philips IU-22 and 7.5-12 mHz transducer. RESULTS: The TSH values corresponding to the 2.5 and 97.5 percentiles were 0.38 IU/mL and 4.23 IU/mL, respectively. TSH levels > 2.5-3.0 IU/mL were observed in 13.1% pregnant women. TSH values > 4 IU/mL were observed in 3.6% of the cases. The T4T and T3T values corresponding to the 2.5 and 97.5 percentiles were 7.8 ug/dL and 16.1 ug/dL; 122 ng/dL and 249 ng/dL, respectively. The FT4 and FT3 values corresponding to the 2.5 and 97.5 percentiles were 0.76 ng/dL and 1.42 ng/dL; 0.21 ng/dL and 0.36 ng/dL, respectively. There was a significant increase in the T3:T4 ratio over the trimesters and in 8% of the samples it was above the reference value for pregnant women. The dosages of UIC did not present statistical differences between the three trimesters of gestation. The medians were 135 ug/L, 153 ug/L and 140 ug/L, respectively. We found UIC < 150 ?g/L in 52.2% of pregnant women. Comparing the group with UIC < 150 ?g/L (iodine deficient) and the group with UIC between 150-250 ug/L (sufficient in iodine), a significant difference was observed in TSH and T3 values in the 2nd trimester (TSH = 2.24 IU/mL and TSH = 1.78 IU/mL and mean T3 = 196 ng/dL and T3 = 181 ng/dL between the deficient and sufficient groups, respectively). There were no significant differences between TG values and thyroid volume over the trimesters. Conclusion: The subclinical hypothyroidism frequency ranged from 3.6% to 13.1%, depending on the adopted criteria. It was not possible to establish frequency of maternal hypothyroxinemia, due to the absence of FT4 cutoff established in our population. Iodine deficiency was found in 52.2% of pregnant women evaluated. Although these pregnant women presented mild iodine deficiency, adaptive mechanisms were necessary to balance thyroid function with possible preferential production of T3, increase in T3:T4 ratio and higher values of TSH. It is concluded that although this is an iodine sufficient region, women could benefit from supplementation of this nutrient during pregnancy
Agnafors, Sara. "A Biopsychosocial and Long Term Perspective on Child Behavioral Problems : Impact of Risk and Resilience." Doctoral thesis, Linköpings universitet, Avdelningen för neuro- och inflammationsvetenskap, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-124209.
Full textRodríguez, Samanillo Luis. "Factores de riesgo obstétricos para Apgar bajo a los 5 minutos en recién nacidos a término : Instituto Especializado Materno Perinatal-año 2003." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2005. https://hdl.handle.net/20.500.12672/1787.
Full textTesis de segunda especialidad
Ramirez, Humari Danayt Carito. "Percepción materna sobre la prevención del sobrepeso y obesidad en niños menores de 5 años en una asociación en Villa El Salvador." Master's thesis, Universidad Nacional Mayor de San Marcos, 2019. https://hdl.handle.net/20.500.12672/11358.
Full textTesis