Dissertations / Theses on the topic 'Materia medica and therapeutics'
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Sklepari, Meropi. "Stability and biophysical characterisation of protein therapeutics." Thesis, University of Warwick, 2017. http://wrap.warwick.ac.uk/98558/.
Full textAlamri, Mubarak. "Discovery of WNK-SPAK/OSR1 signalling inhibitors as potential therapeutics." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8559/.
Full textLone, Mudasir. "Development of nanoscale screening technology for the detection and quantification of aggregation in protein therapeutics." Thesis, University of Nottingham, 2013. http://eprints.nottingham.ac.uk/28808/.
Full textBudd, Patrick G. "Implementation and optimisation of alternative therapeutics for use in Clostridium sporogenes as a delivery vehicle." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/39988/.
Full textGolden, Isaac, and homstudy@netconnect com au. "The potential value of homoeoprophylaxis in the long-term prevention of infectious diseases, and the maintenance of general health in recipients." Swinburne University of Technology, 2002. http://adt.lib.swin.edu.au./public/adt-VSWT20050228.150047.
Full textPontefract, Sarah Katie. "The impact of computerised physician order entry with integrated clinical decision support on pharmacist-physician communication in the hospital setting." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8167/.
Full textHamilton, A. R. "The development and evaluation of antibacterial polymer-phyllosilicate composite systems for the treatment of infected wounds." Thesis, Liverpool John Moores University, 2017. http://researchonline.ljmu.ac.uk/7684/.
Full textDougall, Paul W. R. "Investigation into the effect of formulation on intravenous lipid emulsion metabolism using a novel in vitro fluorescent assay." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/33733/.
Full textLee, Jong Bong. "Optimisation of treatment of cancer based on principles of pharmacokinetics." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/50236/.
Full textMarsh, Georgina E. "Utilising micron-scale 3D printing to investigate particulate interactions for respiratory applications." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/50247/.
Full textFowler, R. C. "Crossing mucosal barriers for non-invasive protein delivery : a vitamin B12-mediated approach." Thesis, University of Nottingham, 2013. http://eprints.nottingham.ac.uk/13029/.
Full textBice, Justin. "Cardioprotection afforded by targeting guanylyl cyclase during early reperfusion." Thesis, Cardiff University, 2012. http://orca.cf.ac.uk/19776/.
Full textWatts, Peter James. "Microspheres for drug-delivery to the colon." Thesis, University of Nottingham, 1992. http://eprints.nottingham.ac.uk/13455/.
Full textPennington, Oliver John. "The development of molecular tools for the expression of prodrug converting enzymes in Clostridium sporogenes." Thesis, University of Nottingham, 2006. http://eprints.nottingham.ac.uk/13295/.
Full textBassetto, Marcella. "Computer-aided design, synthesis and evaluation of potential anti-HCV agents." Thesis, Cardiff University, 2013. http://orca.cf.ac.uk/57024/.
Full textSuberu, John O. "Analysis of plant materials for molecules of pharmaceutical importance." Thesis, University of Warwick, 2013. http://wrap.warwick.ac.uk/58485/.
Full textHoskisson, Paul A. "Micromonospora echinospora (ATCC 15837) growth, differentiation and antibiotic production." Thesis, Liverpool John Moores University, 2002. http://researchonline.ljmu.ac.uk/4923/.
Full textMozafari, Mohammad Reza. "Liposomal delivery of drugs and biologicals : development and characterisation." Thesis, Liverpool John Moores University, 2005. http://researchonline.ljmu.ac.uk/5652/.
Full textBartlett, Alison. "QSAR study of immunotoxicity in antibiotics." Thesis, Liverpool John Moores University, 1995. http://researchonline.ljmu.ac.uk/5135/.
Full textGarekani, Hadi Afrasiabi. "The characterization and compaction properties of manipulated paracetamol crystals." Thesis, Liverpool John Moores University, 1996. http://researchonline.ljmu.ac.uk/5131/.
Full textParmar, Manish M. "Polymorph selection with morphology control using solvents and additives." Thesis, Liverpool John Moores University, 2016. http://researchonline.ljmu.ac.uk/4399/.
Full textAlkut, W. "Mechanisms of resistance to β-lactam antibiotics in Streptomycetes." Thesis, Liverpool John Moores University, 2016. http://researchonline.ljmu.ac.uk/4613/.
Full textKarwi, Qutuba. "Characterisation and mechanisms of thiol-induced protection against myocardial infarction." Thesis, Cardiff University, 2016. http://orca.cf.ac.uk/99908/.
Full textAmali, Mohammed. "Characterisation of the B-lymphocyte response in delayed-type piperacillin hypersensitivity reactions." Thesis, University of Liverpool, 2015. http://livrepository.liverpool.ac.uk/2037919/.
Full textAl-Suhaim, Sultan A. "Use of evidence based pharmacotherapy for cardiovascular disease in Scotland." Thesis, University of Glasgow, 2015. http://theses.gla.ac.uk/6761/.
Full textRaja, Vijay J. "Biological characterisation of a novel and naturally isolated indole alkaloid." Thesis, University of Nottingham, 2015. http://eprints.nottingham.ac.uk/29864/.
Full textElhaneid, Mohamed. "Toxicological assessment of graphene based nanomaterials in cell culture models." Thesis, University of Birmingham, 2019. http://etheses.bham.ac.uk//id/eprint/8881/.
Full textZarnecka, J. M. "Assessing and developing methods to explore the role of molecular shape in computer-aided drug design." Thesis, Liverpool John Moores University, 2018. http://researchonline.ljmu.ac.uk/8888/.
Full textPereira, Catherine. "Kinetics of inhaled antibodies by gamma scintigraphy." Thesis, University of Nottingham, 2013. http://eprints.nottingham.ac.uk/30444/.
Full textZaed, Ahmed Mohamed Faraj. "New tandem reactions for the synthesis of nitrogen containing natural products." Thesis, University of Glasgow, 2012. http://theses.gla.ac.uk/3927/.
Full textAldekhail, Nasser Mohammed N. "Pharmacotherapy and weight management : efficacy and clinical effectiveness in patients with obesity and type 2 diabetes." Thesis, University of Glasgow, 2018. http://theses.gla.ac.uk/8659/.
Full textAmong those who completed the programme, the difference was statistically significant (p =0.005). The association between weight change and anti-diabetic drug type was not explained by differences in sex, initial BMI or age. To conclude, there was a clinically and statistically significant change in weight, HbA1c and FPG in patients with obesity and type 2 diabetes who used orlistat. Of the patients following the GCWMS lifestyle phase, less than 50% succeeded in losing at least 5 kg, with patients who completed the programme being more successful. Participants who lost weight in the lifestyle phase were selected for FWL and experienced the greatest weight loss by the end of phase 2. Those who were unsuccessful in losing 5 kg through the lifestyle programme, were offered orlistat and LCD. The large sample size increased the precision of the results, while the stratification for potential confounding factors increased the study’s validity. A higher proportion of patients were prescribed weight-neutral medications, compared with mixed and weight-gaining anti-diabetic medications. The proportion of patients on weight-gaining diabetes drugs referred to the GCWMS did not alter appreciably following the release of the SIGN guidelines. By the end of the lifestyle treatment phase, patients receiving weight-neutral drugs (metformin, DPP-IV, GLP-1, and SGLT2) were more successful in losing weight than those receiving weight-gaining drugs (SUs, TZDs, and any combination including insulin). The main recommendation from this research are, that further studies are carried out to better establish the best timing of use of orlistat within a weight management programme, that the intensity of phase 2 of the GCWMS is increased, and that prescribers take account of a patient’s current BMI prior when prescribing anti-diabetic medication, especially when recommending weight loss and referring to a weight management programme.
Colthup, Philip Victor. "Assessment of the value of high-performance thin-layer chromatography for the detection and characterisation of drugs and metabolites in biological fluids." Thesis, Liverpool John Moores University, 1993. http://researchonline.ljmu.ac.uk/4941/.
Full textWyszynski, Rafal Wlodzimierz. "Differential control of immune cell function by HIF-1 signalling pathway." Thesis, University of Kent, 2014. https://kar.kent.ac.uk/47691/.
Full textWang, Di, and 王迪. "Molecular and biochemical characterization of therapeutic properties of paeoniae-glycyrrhiza decoction, a Chinese herbal preparation, against antipsychotic-associated hyperprolactinemia." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/193412.
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Patel, Nilesh. "The synthesis of benzothiadiazepines, pyrrolobenzodiazepines and pyrrolobenzothiadiazepines of biological and pharmaceutical relevance." Thesis, University of Huddersfield, 2006. http://eprints.hud.ac.uk/id/eprint/22329/.
Full textAzouz, Wahida Ahmed Abugrara. "Novel methodology to characterise how asthma and chronic obstructive pulmonary disease patients use their inhalers and methods to improve their inhaler technique : objective assessment of how patients use inhalers." Thesis, University of Huddersfield, 2012. http://eprints.hud.ac.uk/id/eprint/17484/.
Full textAlqadi, Abdulaziz Abdullah. "Studies of antihypertensive drug persistence and adherence in the Glasgow Blood Pressure Clinic." Thesis, University of Glasgow, 2017. http://theses.gla.ac.uk/7664/.
Full textPhahamane, Edward Peter. "A group analysis evaluation of the selected members of the acidum family of homoeopathic remedies in terms of known materia medica." Thesis, 2015. http://hdl.handle.net/10321/1338.
Full textHomoeopathy has advanced as an empirical art and has become a modern age science backed by the kind of massive research data and critical reviews that helps scientific knowledge become acceptable within the global knowledge space. Two centuries ago, the practice of homoeopathy was possible with a few hundred proven remedies of that time but as this science developed through both research and collection of empirical data the number of remedies available increased exponentially. As both the study of remedies and the remedy selection process became more challenging, group analysis by famous homoeopaths such as Farrington (1992), Sankaran (2003), Scholten (1993), Mangliavori (in Vidal 2005) emerged. Currently, with a database of over 3000 remedies available for prescription, group analysis, though a contested approach has proven to be an adequate tool that helps consolidate mass homoeopathic data into meaningful groupings that makes both the study of remedies and their application in practice easier. Classifying homoeopathic remedies into groups by means of group analysis and allowing such methods and results thereof to go through rigorous critiquing refines homoeopathic knowledge and improves its ability to sustain itself as a competent science. Homoeopathy has emerged as a technologically inclined science, utilising various software programs enabling more thorough correlation of symptoms and remedies and so improving the prescription process. Software programs have proven to be very useful tools for the development of group analysis. The aim of this study was to extract the common characteristic symptomatology of five selected homoeopathic remedies belonging to the acidum family as represented in the known materia medica and repertory. The acidum remedies appearing in Radar® 10 repertory (Archibel 2008) were analysed in terms of rubric representation (frequency) and the top five were selected for inclusion in the study. The top five remedies were: Nitricum acidum, Phosphoricum acidum, Muriatic acidum, Sulphuricum acidum and Fluoricum acidum. All rubrics in which the selected remedies appeared were extracted using the homoeopathic software package Radar® 10 (Archibel, 2008) and analysed for sensations and active, passive and compensation reactions of the selected remedies, as per Sankaran (2002). The common primary sensations identified were, burning, sore, swelling, pressing, cramping, dryness, weakness, tearing, and coldness. There were also sensations of anxiety, restlessness, delirium, delusions, dullness, sadness and cheerfulness. Active reactions identified were: hot, heat, inflammation and sensitivity. Passive reactions identified were: coldness, numbness and weakness. Compensation reactions identified were: restlessness, hurriedness, intense reaction and passion. Miasmatic keywords as per Sankaran (2002) were used to determine the miasmatic tendencies of the selected top five acidum remedies. In general all acidum remedies appeared to have a dominant syphilitic miasmatic tendency but acidums were present through all the miasms. Their miasmatic tendencies are easily recognised when viewed in the light of their pathophysiological processes. The pathological tendencies of acidum remedies examined in this study include: haemorrhoids, general haemorrhage, syphilis, warts, neoplastic and non-plastic tumours, irritable bowel syndrome (reflux, colic, constipation), rheumatism, muco-cutaneous ulcerations (STIs, Xerostomia, diabetic ulcers) and bone diseases (osteoporosis, osteitis, and peri-osteitis). The results of this research were compared to the findings of Scholten (1993) and Mangialavori and Marotta (2005). It is the researcher’s view that Sankaran’s methodology of group analysis which he used to explore biological groups of remedies (plants and animals) is adequate for use with non-biological groups of remedies such as mineral acidums. The researcher found group analysis methodology worthy as a tool for classifying the mass data of acidum remedies into orderly sets of meaningful data. Group analysis is consistent with the laws and principles of homoeopathy and encourages the use of materia medica and repertory which are fundamental to the study and application of homoeopathic knowledge.
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Naidoo, Kerusha. "A homoeopathic drug proving of Panthera leo with a subsequent comparison of Lac leoninum." Thesis, 2015. http://hdl.handle.net/10321/1335.
Full textIntroduction This study was a double-blind, placebo controlled proving of Panthera leo 30CH (claw of a African lioness); the aim being to determine the effect of this substance induces on healthy persons and in doing do explore the homoeopathic therapeutic potential thereof, in addition a subsequent comparison with the provings of Lac leoninum (milk of a lioness) (Sankaran,1998) (Herrick,1998) was performed. Objectives The primary objective of this proving was to determine the effect that Panthera leo 30 CH on healthy provers so that the therapeutic potential of the substance could be determined. The secondary objective was to compare the Materia medica of Panthera leo with that of Lac leoninum (Herrick, 1998) and Sankaran (1998). Lastly, the third objective was to further develop the homoeopathic Materia medica by adding the remedy picture of Panthera leo. Methodology The drug proving of Panthera leo was conducted as a randomized, exploratory, double blind placebo controlled study. Thirty participants (healthy volunteers) who met the inclusion criteria (Appendix B) participated in the proving, twenty – four were given the verum and the remaining six placebo. Upon obtaining written informed consent the researcher performed a full case history and comprehensive physical examination on each prover before commencement of the proving. A subsequent follow up case history and physical examination at the end of the proving was also performed to establish whether provers had returned to their respective healthy states. The provers took their first dose of the proving remedy at a dosage of 1 dose three times daily for 2 days and recorded all symptoms they experienced in their respective journals according to the guidelines in Appendix C. On completion of the proving, all provers handed in their journals which were then transcribed, assessed and analyzed. An extensive comparison between the proving of Panthera leo and the two provings of Lac leoninum (Herrick, 1998) (Sankaran, 1998) followed. The respective remedies were compared and contrasted with respect to Materia medica and repertory and similarities and differences highlighted. Results A total of 1255 rubrics were obtained of which the mind section of the Materia medica weighed heavily comprising 35 % (435 rubrics) of the proving symptoms, the generals section (11% = 135 rubrics) and head section (9% = 109 rubrics) respectively. Therefore it can be suggested that this remedy’s sphere of action is limited largely to the mind (emotional state) however unique physical indications specifically regarding headaches are also within its sphere of action. Of the total, 1255 rubrics that were obtained only 11% (138 rubrics) where shared with the two other provings of the African lion (Herrick 1998 & Sankaran 1998); as suggested by Naude (2011) one can speculate that these shared symptoms may represent the unique mammalian component of the animal the differences however considerably outweigh the similarities between these provings and for this reason one can conclude that factors in addition to the species of animal from which the remedy is sourced further influence the resultant proving symptoms. Conclusion It can be concluded that Panthera leo 30CH produced clearly observable symptoms in healthy provers who participated in this proving, furthermore there was clear congruency between certain aspects of this proving and that of Herrick and Sankaran however such similarities were limited.
Hull, Ruth Heather. "A group analysis evaluation of the selected psychoactive plant remedies in terms of known materia medica." Thesis, 2016. http://hdl.handle.net/10321/1771.
Full textThere are now several thousand remedies available to a homoeopath and this number is continually increasing with the increase in homoeopathic research and provings. This growing wealth of data does, however, make choosing a homoeopathic remedy difficult and some homoeopaths argue that the essence of homoeopathic remedies are being lost in this excess of data. In an attempt to more accurately see a remedy’s ‘picture’ and gain deeper insight into remedies, Scholten (1993), Sankaran (2005a) and Mangialavori (2010) developed different methods which can now be collectively referred to as “group analysis”. The aim of group analysis is to find symptoms, sensations and pathological tendencies that are common to all remedies within a group. This study involved applying Sankaran’s group analysis approach to the psychoactive plant drug remedies with the rationale of filtering and organizing the mass of data we now have available on this group. This will enable both students and professionals of homoeopathy to develop a deeper understanding, and hence greater utilization, of the psychoactive plant drug remedies. The following five homoeopathic remedies were chosen for this study on the grounds that they have all been extensively proved through both homoeopathic provings and cured clinical cases and there is a vast amount of literature available on these remedies in materia medica and repertories: • Anhalonium lewinii (Cactaceae family) • Cannabis indica (Hamamalidae family) • Coffea cruda (Rubiaceae family) • Nux moschata (Magnolianae family) • Opium (Papaveraceae family) A computer repertory search was conducted using RadarOpus (Archibel, 2014) to extract all rubrics containing the selected remedies. Parameters were set to retain only rubrics that have less than 50 remedies and at least two of the selected psychoactive plant remedies in them. This was to ensure that only well-defined, characteristic remedies were looked at. The rubrics were visually analyzed, compared and contrasted to determine the common sensations within them and mental, general and particular symptoms were analyzed in terms of Sankaran’s model of Vital Sensation (2005a). The vital sensation of the psychoactive plant drug remedies was found to be that of horror, fear or fright. All the remedies belonging to this group experience the sensation of horror either through their perception of pain or through dreams, visions, hallucinations or anxiety. This sensation pervades all these remedies which are constantly trying to escape this sensation by either increasing or decreasing their activity and sensitivity. The active reaction to the sensation of horror is to increase activity. This is expressed through increased sensitivity; mental clarity; sensations of contraction, fullness, heaviness, heat or moisture; delirium, hallucinations and instability. The passive reaction to the sensation of horror is to decrease activity. This is expressed through insensitivity; lack of mental clarity; sensations of expansion, emptiness, lightness, cold or dryness; sleep, stupor and unconsciousness. The compensation, or coping mechanism that psychoactive plant drug remedies develop, is a transcendence of their condition: they transcend, or escape, their condition by no longer feeling or doing anything, by becoming numb and insensitive. The researcher suggests that although the remedies of the psychoactive plant drug group can be classified according to different miasms, the over-riding miasm of this group is the sycotic miasm with its fundamental sense of having a ‘fixed weakness’ within themselves. The researcher also proposes that the psychoactive plant remedies have an affinity for the central nervous system and for ailments caused by strong emotions such as joy, anger, excitement, fear or fright. These remedies tend to produce pathologies of the central nervous system and sleep including increased reflexes, involuntary motions, trembling, jerking; weakness, atrophy, slowness, paralysis; unconsciousness; catalepsy; Autism Spectrum Disorders; hypersensitivity; insensitivity or absence of sensitivity; pain; formication; mental confusion, poor comprehension, nonsensical speech; memory disorders; delirium, hallucinations, schizophrenia; mood disorders; behavioural disorders; anxiety; insomnia, narcolepsy and nightmares. The researcher found group analysis to be a powerful methodology that, if employed correctly, can aid homoeopaths to learn and understand remedies in their ‘totality’.
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Zondi, Gugulethu Moonlight. "A homoeopathic drug proving of Acacia Xanthophloea 30CH, with subsequent comparison to the doctrine of signatures." Thesis, 2016. http://hdl.handle.net/10321/2484.
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Naidoo, Keshia. "A double blind placebo controlled proving and comparative material medica of Ubiquinone." Thesis, 2015. http://hdl.handle.net/10321/1413.
Full textINTRODUCTION Homoeopathy is based on the law of similars meaning the medicine that produces symptoms in a healthy individual will cure the same symptoms in a sick individual (Sankaran, 1991:5). AIM Conducting a proving on Ubiquinone 30CH will lead to an establishment of its therapeutic potential through the application of the law of similars thus adding to the Materia Medica and advancing Homoeopathy (Vithoulkas, 2002). It was hypothesised that the 30CH potency of Ubiquinone would clearly produce observable signs and symptoms in healthy prover’s. It was further hypothesised that a comparison of Ubiquinone to those remedies yielding the highest numerical value and total number of rubrics on repertorisation of the proving symptoms would elucidate differences and similarities between Ubiquinone and other Homoeopathic remedies to clarify its therapeutic indications. It was hypothesised that in this manner a better understanding of Ubiquinone and its relationship to other Homoeopathic remedies would be gained. Methodology The proving of Ubiquinone 30CH was a randomised, double blind placebo controlled study, using the 30th centesimal potency and a total of 26 participants who met the inclusion criteria. Each prover was provided with a journal to record their symptoms daily. The data extracted from the journals were added to the case histories and physical examinations to compile a proving profile. The identity of the substance was revealed and the information was correlated after completion of the proving. The symptoms found were translated into Materia Medica and repertory language. Once the proving was concluded, a comparison to the remedies yielding the highest numerical value and total number of rubrics on repertorisation - which is the technique of using a repertory to identify the Homoeopathic medicines whose Materia Medica corresponds most closely to the clinical picture of the patient and from amongst which a simillimum may be chosen (Swayne, 2000:183) - was compared to the proving symptoms. Results The remedy’s main influence was on the mental and physical state. The most prominent symptoms seen in the mental sphere were extreme irritability and exhaustion. There was a sense of emotional fragility with a desire to be alone. On the physical side, headaches were common and weakening pains of the extremities were experienced. It can be concluded that the 30CH potency of Ubiquinone, if used precisely according to Homoeopathic principles, can be applied to a clinical setting, as the extensive range of symptoms produced during the proving suggests an equally wide array of application of the remedy Ubiquinone. Conclusion One of the downfalls of Homoeopathy is the limited number of provings being done, (Vithoulkas, 2002). Vithoulkas (2002:143) maintains that in order for Homoeopathy to advance, it is necessary to perform provings on new substances to expand the Homoeopathic armamentarium. Increasing the number of remedies in the Materia Medica facilitates greater accuracy and individualisation when treating patients (Wright, 1999). According to Herrick (1998) numerous cases cannot be solved because many of the most important remedies have not yet been developed. The purpose of this study was to increase the knowledge of drug substances due to the limited amount of information in our current Materia Medicas, by investigating the therapeutic potential of Ubiquinone 30CH. The investigation supported the hypothesis that Ubiquinone would produce clearly observable signs and symptoms in healthy volunteers. It is essential that the proving symptoms be verified and expanded through clinical use and with further proving of Ubiquinone in various potencies so that it becomes a well utilised remedy in the future.
Ramnarayan, Sumir. "A double blind placebo controlled homoeopathic proving of Malus domestica 30CH, with a subsequent comparative analysis according to the doctrine of signatures." Thesis, 2014. http://hdl.handle.net/10321/1060.
Full textThe purpose of this research study was to determine any therapeutic significance of Malus domestica (domestic apple) in the potentised, homoeopathic form and to contribute this information to the body of the homoeopathic materia medica. It was further hypothesised that some proving symptoms experienced by the provers during the research study would show a resemblance to unique characteristics of the plant in terms of its natural appearance and cultural references. This involved a detailed doctrine of signatures analysis of Malus domestica based on an extensive literature review. Combining a proving research study with comparative analysis to the doctrine of signatures helped to clarify and verify the remedy’s potential therapeutic value. Methodology This homoeopathic proving was carried out in the form of a double blind placebo controlled study of Malus domestica 30CH with a total of 30 provers. The prover sample was randomly divided into two groups: 24 provers (80%) into the verum group and the remaining six provers (20%) into the placebo group. The provers were unaware of either the proving substance or the potency used. Participants were required to record their mental, emotional and physical status’ one week prior to administration of the proving powders as a form of control for comparison of symptoms post administration of the proving remedy. Thorough physical examinations and case histories of each prover were taken prior to and after the proving period. Provers ingested one powder three times a day for three days and recorded their symptoms daily in a journal. The duration of the proving period spanned five weeks. During this period researchers were in constant contact with all participants. Once the proving period was complete, all journals were gathered and the information therein translated into materia medica and repertory format so as to develop the remedy picture of Malus domestica 30CH. A comparison between the symptomatology produced in the provers and the doctrine of signatures was then performed. Results A wide range of symptoms were documented by the provers. The results revealed an affinity to the mental plane – the most striking being the theme of being disconnected and separated from others in the environment as well as within one’s self. Marked polarities were depicted as follows: Anger/irritability vs. calmness/tranquility; Depression/sadness vs. cheerfulness; Confusion vs. concentration/clarity of mind; Connection vs. disconnection. Physically, symptoms concerning the extremities were numerous, with provers describing symptoms of their limbs being disconnected/separated as well. Head symptoms were also numerous as provers described a wide range of headaches, as well as headaches that were associated with eye symptoms. Abdominal symptoms manifesting as cramping associated with diarrhoea and, in some cases, constipation were documented. Dizziness associated with the sensation of the head floating was common as well. Numerous themes arising from dreams were recorded by provers, with a clear affinity to family members as well as dreams of social gatherings and banquets. Provers dreamt of family members placed in precarious situations wherein the lives of their loved ones were at risk, whilst the emotion of guilt was expressed in certain dreams regarding parties and banquets. The comparison between the homoeopathic drug proving of Malus domestica 30CH and the doctrine of signatures brought many similarities to light, with most of these similarities relating to the mind, extremities and head. Conclusion As hypothesised Malus domestica 30CH produced clearly observable symptoms in healthy provers. On comparison, the proving remedy and the doctrine of signatures brought many parallels to light – the majority of which related to the mind, extremities and head. To gain a complete remedy picture of Malus domestica it is imperative that further research into the symptomatology of different homoeopathic potencies be conducted.
Swana-Sikwata, Tembeka Stella. "A homoeopathic drug proving of Hoodia gordonii 30CH, with a subsequent comparison of proving symptomatology to its toxicology as a raw substance and to homoeopathic remedies of repertorial similarity." Thesis, 2016. http://hdl.handle.net/10321/2568.
Full textIntroduction The aim of this study was to determine the effect of Hoodia gordonii 30CH on healthy provers, and to record the clearly observable signs and symptoms produced and the subsequent comparison to its toxicology as a raw substance and to homoeopathic remedies of reportorial similarity. Methodology The investigation was a randomised, double-blind placebo controlled trial, using the substance in the 30th potency. This was prepared according to the German Homoeopathic Pharmacopoeia. A sample of 20 provers, in good health, was recruited. Sixteen received verum as the experimental group and four in the control group received a placebo. Each of the 20 provers received a journal in which they recorded symptoms on a daily basis for a period of six weeks, including a one week observation prior to taking the powders, and a period of five weeks after administration of the powders. The information from the journals and case histories was edited, collated and translated into materia medica and repertory language and used to compile a proving profile of the remedy by qualitative methods. The remedy was only revealed to the participants after completion of the proving study period. The researcher compared the similarities and new symptoms of the remedy with the existing knowledge of its toxicology to prove the first hypothesis. A detailed and extensive literature review of Hoodia gordonii’s unique characteristics was conducted. A further comparison with other similar remedies according to the highest numerical number of rubrics on repertorisation was conducted. Results The proving remedy produced a wide variety of symptoms on the mental, emotional and physical levels of which many had polarities. In broad terms the following were identified from the proving symptoms of Hoodia gordonii: • Increased confidence and feeling refreshed, renewed energy, cheerfulness, concentration, alertness, calm, forgetfulness, unhappy, sadness and depression with desire to be left alone. • Anxiety for unknown reason and for the future, about finances; restlessness and busyness. • Tiredness, fatigue and exhaustion. • Positive feeling regarding home and family. • Mental exhaustion and aversion to study. • Common sensations were throbbing, pulsating, sharp, aching, heat, pressing, heavy, pulling, splitting, cramps. • Perceived attack or danger in dreams. • Painless diarrhea and constipation, nausea, headaches, vertigo, sore red eyes, nasal congestion and sinuses, toothache, tonsillitis and dryness of throat; bronchitis, heart palpitations. • Menses with breast tenderness and increased sexual stimulation, joint pain. • Unquenchable thirst, polyuria, appetite increase and decrease, sleeplessness and sleepiness with deep sleep, cold, increase perspiration, influenza and depressed immune function. Conclusion The data obtained from this proving study of Hoodia gordonii when comparing the new symptoms of the remedy with similarities to the existing knowledge of its toxicology proved the first hypothesis to be true. Three hundred and twenty four rubrics were produced and 17 were new rubrics; of these a total of 20 rubrics that represented the essence of the remedy were selected and used in the repertorisation process. A comparison of the highest numerical value of rubrics with other similar remedies on repertorisation found Hoodia gordonii 30CH to be most similar to: Atropa belladonna, Phosphorus, Lachesis mutus, Sulphur and Veratrum album.
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Pillay, Karasee. "A double-blind homoeopathic drug proving of Curcuma longa 30CH, analysing sympotomatology [i.e. symptomatology] in relation to the doctrine of signatures." Thesis, 2011. http://hdl.handle.net/10321/665.
Full textThe aim of this study was to determine the effect that Curcuma longa 30CH would have on healthy individuals, and record the particular signs and symptoms produced. These signs and symptoms determine the therapeutic indications of this remedy, so that it may be prescribed according to the homoeopathic Law of Similars. The second aim of this study was to analyse the symptomatology of Curcuma longa 30CH in relation to a Doctrine of Signatures analysis of the Curcuma longa plant, in order to facilitate a more comprehensive understanding of the materia medica of this substance. Design The homoeopathic proving of Curcuma longa in 30CH potency took the form of a double blind, randomized, placebo controlled trial. Thirty healthy provers were selected on the basis of them meeting with the necessary inclusion criteria (Appendix A). The provers were randomly divided into 2 groups, of which 20% (6 of the 30 provers) formed the placebo group and received non-medicated powders, and the remaining 80% (24 of the 30 provers) received medicated powders (verum). The 2 groups were not aware of the nature of the substance that they were proving or the potency used. The provers recorded their mental, physical and emotional states over a period of a week prior to taking the remedy in order to establish a baseline for comparison after the administration of the remedy. Both verum and placebo were dispensed in the form of 6 powders. Each powder was taken sublingually 3 times daily for 2 days or until the prover experienced the onset of any symptoms. Each prover kept a journal and recorded their proving signs and symptoms daily after administration of the remedy or the placebo. The data was collected and extracted from these journals and then assessed by the researcher for suitability to be included in the materia medica of Curcuma longa. All data gathered from the case histories (Appendix C), physical examinations and group discussions were also considered for inclusion. Results A variety of mental, emotional and physical symptoms were produced and included in the materia medica of Curcuma longa. There were a total number of 202 symptoms that were produced as a result of the remedy, which resulted in the formulation of 141 rubrics. The main mental and emotional symptoms that surfaced during the proving were depression, a deep sadness, changeability of moods, courage/confidence, relaxed/ calm and less anger, agility, increased concentration, and vivid dreams. The physical symptoms noted were diarrhea, change in energy levels (too much or too little energy), burning sensations, headaches, heart palpitations and increased breathing rates. The symptoms that came about during the proving clearly showed correlation and association with the nature and description of the Turmeric plant, this is in keeping with findings of previous provings (Pistorius, 2006; Webster, 2002; Speckmeier, 2008 & Pather, 2009), furthermore as suggested by Richardson-Boedler (1999:173) the Doctrine of Signatures analysis of the Turmeric plant facilitated in the interpretation of the proving symptoms and thus the materia medica of the remedy.
Rajkoomar, Suhana. "A double-blind homoeopathic drug proving of Curcuma longa 30CH with the subsequent comparison to the Ayurvedic and phytotherapeutic indications thereof." Thesis, 2011. http://hdl.handle.net/10321/663.
Full textIntroduction The purpose of this study was to determine the therapeutic potential of Curcuma longa 30CH when administered to healthy individuals, thus revealing the materia medica of the substance. It was also the aim of this study to compare the existing therapeutic indications of the substance to the proving symptomatology. Methodology The proving took the form of a double-blind placebo controlled study and was conducted by two Master’s in Technology: Homoeopathy students using 30 healthy subjects. Twenty four provers were given the active medication and six provers were given the placebo. The remedy was manufactured according to the German Homoeopathic Pharmacopoeia in 30CH potency. The proving ran for a period of six weeks. Results The symptoms extracted from the proving were placed in different sections according to the repertory and was compared to the Ayurvedic and Phytotherapeutic indications of Curcuma longa. There were 202 symptoms produced as a result of the remedy, 141 rubrics were formulated using these symptoms. The largest number of rubrics i ii was allocated to the mind, head and dreams section of the repertory, other smaller sections of prominence included the eye, ear, nose and throat sections. A wealth of information was gained once the comparison was made between Curcuma longa 30CH and the Phytotherapeutic and Ayurvedic indications of use. Similarities between the materia medica of Curcuma longa and the Phytotherapeutic indications of use were found to exist with respect to sections such as eye, nose, face, stomach, stool, respiration, back, extremities, skin and generals. Conclusion The administration of Curcuma longa 30C to healthy provers according to the methodological protocol of this study resulted in the production of a variety of defined proving symptoms which comprise the materia medica thereof (first objective of the study). The subsequent comparison of the proving symptoms with the existing indications of Turmeric as an Ayurvedic and Phytotherapeutic medicine (second objective of the study) revealed clear correlations in a variety of defined areas.
Gobind, Anitha. "A homoeopathic drug proving of Acacia xanthophloea 30CH with a subsequent comparison to its use in African medical tradition." Thesis, 2016. http://hdl.handle.net/10321/1769.
Full textAim The aim of this homoeopathic proving study was to determine and document the arising symptomatology of Acacia xanthophloea (Fever tree) in the potentised homoeopathic form, 30CH, and to provide this data for inclusion to the homoeopathic materia medica. The results of this proving study and comparative analysis to African traditional medicinal uses of this substance confirms the potential therapeutic value of the remedy. Methodology The homoeopathic drug proving of Acacia xanthophloea 30CH was conducted in the form of a double blinded placebo controlled study. The investigation consisted of a total of 30 provers divided equally between two researchers ((A. Gobind and G. Zondi). The sample was randomly divided into two groups in which 24 provers(80%) were assigned into the verum group and the remaining six provers (20%) were allocated to the placebo group. All provers were requested to record their daily symptoms on the physical, mental and emotional planes in their journals for one week prior to administration of the proving substance. This formed as a mode of control for the comparison of symptomatology for the pre-proving and post proving period. A thorough case history was taken and physical examination performed on each prover before the commencement of the proving and after the duration of the proving period. Each prover received a total of nine powders. Starting on day 8 of the study the provers consumed one powder three times a day for three days and documented their daily symptoms in a journal. The duration of the proving term was six weeks in total. During this interval the researcher maintained consistent contact with the provers. Upon completion of the proving period all journals were collected and the information contained within these journals was translated into the materia medica and repertory format. This facilitated the establishment of the remedy portrait of Acacia xanthophloea 30CH. A subsequent comparison between the symptomatology that materialised in the provers and the African traditional medicinal uses was duly conducted. Results An extensive range of symptoms was reported by the provers. The outstanding themes that emanated from this proving on the mental plane include anger, anxiety, aversion to company, cheerful, depression, irritability, mood swings, restlessness, tranquillity and stress. A broad range of headaches were described with some headaches being associated with the eye. There were many eye symptoms displayed by the provers which include itching, redness, burning sensation and pain. The stomach symptoms revealed marked increased thirst, changeable appetite, bloating, constipation and diarrhoea with watery stools.The female genitalia / sex indicated several symptoms ranging from painful menstruation, bleeding and copious blood flow.The greatest number of symptoms in a system was associated with extremities, producing the greatest number of rubrics in the repertory section. Dream themes depicted by the provers were especially visionary, about family and friends in addition to other themes. The correlation process between the homoeopathic drug proving of Acacia xanthophloea 30CH and the African traditional medicinal use of the substance brought several resemblances to light.There were clear similarities with the eye symptoms, gastrointestinal symptoms and headaches. Conclusion As hypothesised Acacia xanthophloea 30CH did produce distinctly observable signs and symptoms when administered to healthy provers. The symptoms that emerged during the proving provide evidence that an overlay exists between the remedy Acacia xanthphloea 30CH and the traditional use of the crude substance Acacia xanthophloea. The researcher proposes that further research should be conducted to determine the symptomatology of various homoeopathic potencies so that a complete image of the remedy Acacia xanthophloea 30CH can be established and the clinical applications can be broadened.
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Macquet-Maurel, Louise. "The efficacy of Dioscorea villosa cream in the treatment of menopausal syndrome." Thesis, 2003. http://hdl.handle.net/10321/2774.
Full textThe purpose of this randomised double-blind placebo-controlled study was to evaluate the efficacy of Oioscorea vil/osa cream in the treatment of menopausal syndrome in terms of subjective and objective data; and to compare the subjective data with that obtained from a concurrent study of ProgestoNat\xAE cream (McTeer, 2003).
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Long, Bryan Henry. "A study of the relationship between the natural history of the Solanaceae species and the general and mental symptomatology of the Solanaceae remedies utilised in homoeopathy." Thesis, 2011. http://hdl.handle.net/10321/664.
Full textUntil recently, various attempts have been made to simplify the prescription process in homoeopathic prescribing. The doctrine of signatures, miasmatic theory, the homoeopathic repertory and more recently, kingdom analysis by authors such as Sankaran (1994) and Scholten (1993) are some of the attempts that have been made to understand the materia medica. With the materia medica constantly expanding and considering that plants make up a significant percentage of the materia medica (Kayne, 2006), it is evident that new systems of homoeopathic prescribing are continually needed to help practitioners both study the remedies and prescribe more accurately. Aim The Solanaceae plant family are an important and well utilised plant family in homoeopathy (Vermeulen, 2004). Considering this, it was felt that a study investigating the relationship of the natural history of the family to its general and mental symptoms be conducted in order to apply a previously unexplored research paradigm in order to create a greater understanding of Solanaceae remedies utilised in homoeopathy. The study conducted was a non empirical correlation study of the Solanaceae plant family‟s natural history and general and mental symptoms manifested in Solanaceae remedies utilised in homoeopathy. The aims of the study were to establish if commonalties existed between general and mental symptoms of individual remedies belonging the Solanaceae family and their natural histories, as well as to establish if collective commonalities and correlations existed between the general and mental symptoms and the natural history of the Solanaceae family as a whole. Methodology The homoeopathic remedies obtained from the Solanaceae family of plants for the study were analysed in terms of rubric representation (size) using homoeopathic software packages, Radar 10.4 (Archibel, 2009b) and v Encyclopedia Homoeopathica (Archibel, 2009a) a sample selection was chosen. This selection was analysed in terms of general and mental rubrics. Qualitative thematic analysis was used to establish commonalities in keyword concepts between the respective natural histories of the studied family and their respective general and mental symptoms. Keywords obtained from data tables which included criteria such as habitat and distribution, plant description, active principles (primary alkaloids), uses, physiological action if ingested, historical significance, mythology and toxicology were subjected to thesaurus consultation and tabulated in an attempt to identify synonyms relating to the general and mental symptoms of individual remedies of the sample group in the study. This facilitated in the grouping of similar themes. Once commonalities pertaining to each individual species and remedy was further tabulated and discussed in terms of keywords relating to their natural histories, a collective analysis of common correlations between the plant family as a whole was performed. Results Common themes related to general and mental symptoms and to the natural histories of species in the study included “aggression” found in Atropa belladonna, “depression” found in Solanum dulcamara, “anxiety” found in Datura stramonium, “confusion” found in Hyoscyamus niger, “burns” found in Capsicum annuum, “ convulsions” found in Nicotiana tabacum , “ hallucinations” found in Mandragora officinarum and “delirium” found in Solanum nigrum. Common themes relating to general and mental symptoms and the natural history of the Solanaceae plant family as a whole included convulsions, hallucinations, confusion and anxiety. These themes were further compared to themes exhibited in Solanaceae studies conducted by Mangialavori (2007) and Sankaran (2002).
Hoosen, Asima Goolam. "A homoeopathic drug proving of Acridotheres tristis." Thesis, 2010. http://hdl.handle.net/10321/695.
Full textIntroduction The aim of the study was to determine the effect of Acridotheres tristis 30CH on healthy volunteers (provers) and to record the clearly observable signs and symptoms produced, so that Acridotheres tristis 30CH may be prescribed according to the Law of Similars, as required by homoeopathy. Methodology The proving of Acridotheres tristis took the form of a randomised, placebocontrolled trial on 30 healthy volunteers who met inclusion criteria. The 30th centesimal potency of the tail feather was administered as lactose powders and fifty percent of provers were randomly administered an identical placebo-control substance. The collection of the data from the provers took the form of a journal in which each prover‟s symptoms were recorded for six weeks, including a one-week observation period prior to taking the powders, and a proving period of five weeks after administration of powders. On completion of the proving, each journal was assessed by the researcher to determine the suitability of the recorded symptoms for inclusion in the materia medica of Acridotheres tristis. These symptoms were then translated into the language of the materia medica and repertory and the remedy picture then formulated. Data from case histories, physical examinations and group discussions were also taken into account during the analysis of the proving symptoms. Results The homoeopathic drug proving of Acridotheres tristis, conducted as a doubleiii blind, randomised and placebo-controlled study produced a wide range of symptoms. In the collated edited data arising from the proving 396 journal entries were extracted and 595 rubrics in total were formulated, of which 56 rubrics were new. The main symptoms belonging to the mental and emotional spheres of this remedy include depression, anxiety, memory weakness and isolation accompanied by a need for solitude. The characteristic physical symptoms include headaches, dizziness, extreme fatigue, skin eruptions especially pimples and rashes, haemorrhoids, numbness and severe dysmenorrhoea. Other symptoms indicate a possible use in the treatment of gastro-intestinal complaints which include nausea, abdominal cramps, abdominal distention and heartburn. Conclusion The investigation supported the hypothesis that Acridotheres tristis would produce clearly observable signs and symptoms in healthy volunteers. It is essential that the proving symptoms be verified and expanded through clinical trials and further provings of Acridotheres tristis in various potencies, so that it becomes well-utilized remedy in the future.