Relevant bibliographies by topics / Materia medica and therapeutics

Academic literature on the topic 'Materia medica and therapeutics'

Author: Grafiati
Published: 4 June 2021
Last updated: 30 July 2024

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Journal articles on the topic "Materia medica and therapeutics"

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Khanam, Dr Henna, and Dr Supriya Halder. "Cowpertwaite’s textbook of Materia Medica & therapeutics: A book review." International Journal of Homoeopathic Sciences 6, no. 3 (July 1, 2022): 17–19. http://dx.doi.org/10.33545/26164485.2022.v6.i3a.592.

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Aronson, J. "When I use a word ... * Materia medica, clinical pharmacology, and therapeutics." QJM 103, no. 5 (July 22, 2009): 361–63. http://dx.doi.org/10.1093/qjmed/hcp097.

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Tripathy, Tridibesh, Ms Navya Mall, Mr Prabhat Kumar, Shankar Das, Dharmendra Pratap Singh, Rakesh Dwivedi, Umakant Prusty, et al. "Homoeopathy in the Eyes of Legislation in India." Scholars International Journal of Law, Crime and Justice 7, no. 01 (January 9, 2024): 1. http://dx.doi.org/10.36348/sijlcj.2024.v07i01.001.

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Therapeutics systems are governed by public health laws of the nations in which these are rolled out & practiced. The current article discusses the therapeutic system of Homoeopathy of AYUSH in India & the public health laws that govern this therapeutic system in India. The next step which the article goes through is the journey of the therapeutic system in the nation which becomes the pivotal for the article. The current article deals with the current situation of the homoeopathic therapeutic system at global followed by the national level. As an intervention strategy to deal with the roll out modalities of homoeopathy, the article discusses the journey of its related public health laws also. Finally, the article discusses the role of homoeopathy of AYUSH ministry of India in the current context & proposes a multi stage involvement based on the successful therapeutics in Homoeopathic Materia Medica. The focus of the article on homoeopathy & its related public health laws is critical as it can cover masses as it is cost effective, therapeutically effective & has no side effects. In order to achieve the roll out of these beneficial properties, the related public health laws need effective implementation.
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Pearson, Howard A. "Lectures on the Diseases of Children by Eli Ives, MD, of Yale and New Haven: America's First Academic Pediatrician." Pediatrics 77, no. 5 (May 1, 1986): 680–86. http://dx.doi.org/10.1542/peds.77.5.680.

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Eli Ives of New Haven, CT and Yale University was a successful and respected practitioner, professor, and medical statesman. For nearly 40 years between 1813 and 1852, he lectured to an estimated 1,500 Yale medical students on materia medica, botany, the theory and practice of medicine, and the diseases of children. Some of those lectures, meticulously recorded in flowing penmanship by Yale medical students during this time, are preserved in the manuscript and archives section of Yale University's Sterling Library. The Ives Lectures on Diseases of Children represent the first systematic and dedicated American course of instruction in what today is known as the specialty of pediatrics. During the 1820s, Ives' title at Yale was Professor of Materia Medica, Botany, and the Diseases of Children and so he held the earliest American academic appointment in pediatrics. There were other early 19th century academic physicians with demonstrated interest and involvement in children and their diseases.1 These pediatric pioneers included William Potts Dewees of the University of Pennsylvania and John Eberle of the Jefferson and Cincinatti Medical Colleges who authored early American pediatric textbooks. However, they did not have formal academic titles nor did they present separate substantive courses in pediatrics at their institutions. By the latter half of the 19th century pediatrics began to attain academic recognition in the United States. Dr Abraham Jacobi of New York established a children's clinic at the New York Medical College in 1861. He held the academic title of Professor of Infantile Pathology and Therapeutics and lectured on the diseases of children.
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Huang, Ting, Yunbin Jiang, Yanfei Zhang, Yutian Lei, and Guihua Jiang. "Current application of metabolomics in the elucidation of processing mechanisms used in Chinese materia medica: A review." Tropical Journal of Pharmaceutical Research 19, no. 6 (November 16, 2020): 1321–27. http://dx.doi.org/10.4314/tjpr.v19i6.29.

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Processing, a key characteristic of traditional Chinese medicine (TCM), enhances the efficacy and safety of Chinese materia medica (CMM) in clinics. It plays an important role in TCM. Studies on processing mechanisms involved in CMM promote the development of TCM. However, most studies on the mechanisms used for processing CMM do not reflect the holistic theory of TCM because they are based only on analysis of some specific chemical components and biochemical indices which do not support the TCM characteristics of network target and multicomponent therapeutics. Fortunately, the perspective of systems biology is consistent with the holistic theory of TCM. Metabolomics, a key tool in systems biology, has been widely used to investigate the processing mechanism of CMM for many years. In this work, current applications of metabolomics in elucidating mechanisms used for processing of CMM were systematically reviewed and discussed in terms of changes in chemical components, toxicity and efficacy of CMM before and after processing. This work provides researchers a clear and concise reference on the current application of metabolomics in investigation of mechanisms used in processing of CMM. Moreover, this work provides a guide on how to investigate the mechanisms used in processing of CMM, based on metabolomics. Keywords: Chinese materia medica, Processing mechanism, Metabolomics, Holistic theory
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Rzeźnicka, Zofia, and Maciej Kokoszko. "Wine and Myrrh as Medicaments or a Commentary on Some Aspects of Ancient and Byzantine Mediterranean Society." Studia Ceranea 9 (December 30, 2019): 615–55. http://dx.doi.org/10.18778/2084-140x.09.31.

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The present study has resulted from a close reading of prescriptions for therapeutic wines inserted in book V of De materia medica by Pedanius Dioscorides, the eminent expert in materia medica of the 1st century A.D. The authors emphasise the role of wine varieties and selected flavourings (and especially of myrrh) in order to determine the social status of those to whom the formulas were addressed. This perspective gives the researchers ample opportunity for elaborating not only on the significance of wine in medical procedures but also for underscoring the importance of a number of aromatics in pharmacopoeia of antiquity and Byzantium. The analysis of seven selected formulas turns out to provide a fairly in-depth insight into Mediterranean society over a prolonged period of time, and leads the authors to draw the following conclusions. First, they suggest that medical doctors were social-inequality-conscious and that Dioscorides and his followers felt the obligation to treat both the poor and the rich. Second, they prove physicians’ expertise in materia medica, exemplifying how they were capable of adjusting market value of components used in their prescriptions to financial capacities of the patients. Third, the researchers circumstantiate the place of medical knowledge in ancient, and later on in Byzantine society. Last but not least, they demonstrate that medical treatises are an important source of knowledge, and therefore should be more often made use of by historians dealing with economic and social history of antiquity and Byzantium.
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Kara, Shamini, and Gyandas Wadhwani. "Two Clinical Experiences with a New Sarcode: Potentised Mitral Valve in LM Potencies." Homœopathic Links 31, no. 04 (December 2018): 241–47. http://dx.doi.org/10.1055/s-0038-1677545.

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AbstractSarcodes are an important part of homeopathic materia medica, but their use is ambiguous. Mitral valve is yet another addition to the list but lacking in guidelines for therapeutic application based on homoeopathic drug proving data. Two clinical cases are outlined that empirically received potentised mitral valve in ascending LM potencies and experienced an improved quality of life that was corroborated with outcome in relation to impact of daily living (ORIDL). Potentised mitral valve may be a valuable addition to our materia medica after it has been proved according to homoeopathic guidelines.
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Wu, D. Y., X. Y. Zhang, and X. L. Zhou. "Properties and Therapeutic Efficacy of Chinese Materia Medica Based on Strategy Pattern." Journal of Physics: Conference Series 1207 (April 2019): 012004. http://dx.doi.org/10.1088/1742-6596/1207/1/012004.

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Lees, P., L. Pelligand, M. Whiting, D. Chambers, P.-L. Toutain, and M. L. Whitehead. "Comparison of veterinary drugs and veterinary homeopathy: part 1." Veterinary Record 181, no. 7 (August 11, 2017): 170–76. http://dx.doi.org/10.1136/vr.104278.

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For many years after its invention around 1796, homeopathy was widely used in people and later in animals. Over the intervening period (1796-2016) pharmacology emerged as a science from Materia Medica (medicinal materials) to become the mainstay of veterinary therapeutics. There remains today a much smaller, but significant, use of homeopathy by veterinary surgeons. Homeopathic products are sometimes administered when conventional drug therapies have not succeeded, but are also used as alternatives to scientifically based therapies and licensed products. The principles underlying the veterinary use of drug-based and homeopathic products are polar opposites; this provides the basis for comparison between them. This two-part review compares and contrasts the two treatment forms in respect of history, constituents, methods of preparation, known or postulated mechanisms underlying responses, the legal basis for use and scientific credibility in the 21st century. Part 1 begins with a consideration of why therapeutic products actually work or appear to do so.
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Barreiros, Bruno, and Palmira Fontes da Costa. "Materia Medica and the History of the Book in Seventeenth-Century Portugal." Nuncius 36, no. 2 (June 23, 2021): 394–430. http://dx.doi.org/10.1163/18253911-03602007.

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Abstract This article provides an analysis of the most successful books on materia medica printed in Portugal in the seventeenth century and their influence on subsequent works. The study is informed by methodologies and concerns from the field of the history of the book and pays particular attention to paratexts, genres as well as to physical formats. It shows that these elements were fundamental in defining intended audiences and in constructing strategies of legitimation for their authors. In addition, it assesses issues of readership by considering the marginalia preserved in some copies of these books. The investigation has also into account a significant number of manuscripts on the subject. In spite of their limited circulation, this article shows the advantage of manuscript culture in the dissemination of knowledge on materia medica. Since they could circumvent censorship, particularly in the case of chemical remedies, they reveal a more open approach towards therapeutic innovations and the integration of new ideas and practices.
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Dissertations / Theses on the topic "Materia medica and therapeutics"

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Sklepari, Meropi. "Stability and biophysical characterisation of protein therapeutics." Thesis, University of Warwick, 2017. http://wrap.warwick.ac.uk/98558/.

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For the past two decades, the development of protein therapeutics has significantly expanded with numerous biopharmaceutical and biosimilar products entering the medicine market every year, and even more queuing in the pipeline globally. Biologics are very complex molecules and therefore extremely sensitive to minor changes in the manufacturing process, which can result in heterogeneity and affect the stability, potency and immunogenicity of the final product. Public health organisations, such as EMA (European Medicines Agency), require that biological products should be extensively tested for their similarity to the original drug (in the case of a biosimilar) as well as to products from different batches (batch-to-batch comparison). The issued guidelines focus, among other tests, on physicochemical characterisation of these molecules. The suggested analytical techniques, however, are only vaguely named in the specifications, leaving the final decision to the manufacturers. The present work focuses on the use of different combinations of analytical techniques with an aim to demonstrate similarity or dissimilarity between two or more samples. The selected instrumental techniques are characterised by their simplicity and are able to detect structural differences and microheterogeneity of the active ingredient in different samples, aggregation, degradation and post-translational modifications (PTMs). Seven studies were completed in total, each one to a different extent, and these included protein therapeutics such as insulin and monoclonal antibodies. The applied techniques served for primary (MS),* secondary (far-UV CD, FT-IR) and tertiary structure (near-UV CD, fluorescence) comparison of the examined samples. Particle size comparability and detection of aggregation was achieved with DLS, and higher-order structure comparison with 1D 1 H-NMR. Coupling of the techniques with temperature-dependent measurements enabled further comparison on the thermal stability of the samples and provided confidence in the observed (at room temperature) results. The acquired empirical experience pointed out the advantages and disadvantages of each technique compared to the rest of the techniques, possible solutions to the encountered challenges, and the cases that one technique can be used instead of another or as complementary to it. Finally, a potential SOP is suggested, advising on which biophysical techniques should be used depending on the structure of the protein that is examined and its formulation.
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Alamri, Mubarak. "Discovery of WNK-SPAK/OSR1 signalling inhibitors as potential therapeutics." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8559/.

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Protein kinases are major drug targets for many diseases. Among these are the STE20/SPS1-related proline/alanine-rich kinase (SPAK) and the oxidative- stress-responsive kinase 1 (OSR1), which are two related serine/threonine protein kinases. Both kinases are key components of the WNK-SPAK/OSR1 signalling pathway that has emerged as a key regulator of electrolyte homeostasis, body fluid and blood pressure. Various knock-in and knock-out SPAK and OSR1 mouse models exhibited reduced blood pressure. This highlighted SPAK and OSR1 kinases as promising targets in the treatment of hypertension. Encouraged by this, this project was initiated to discover specific WNK-signalling inhibitors by targeting SPAK and OSR1 kinases as potential novel antihypertensive agents. My work led to the identification of an allosteric pocket located in the highly conserved C-terminal domains of SPAK and OSR1, which influences their kinase activities. Using in silico screening, Rafoxanide, an anti-parasitic agent, was identified as a novel allosteric inhibitor of SPAK and OSR1. Additionally, high throughput screening led to the discovery of the clinically used agent, Verteporfin, as a novel and potent WNK-signalling inhibitor. Moreover, several fragment-binders to the C-terminal domain of OSR1 kinase were identified using NMRfragment based screening. In addition, the NMR backbone assignments of the C-terminal domain of OSR1 kinase were determined and used to map the previously unknown binding site of different OSR1 and SPAK inhibitors. Collectively, these findings have significantly advanced the field of SPAK and OSR1 kinase inhibition and provided key tools that will facilitate the future discovery of other SPAK and OSR1 kinase inhibitors.
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Lone, Mudasir. "Development of nanoscale screening technology for the detection and quantification of aggregation in protein therapeutics." Thesis, University of Nottingham, 2013. http://eprints.nottingham.ac.uk/28808/.

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The use of proteins as therapeutics is one of the fastest growing sectors of the pharmaceutical industry, particularly monoclonal antibodies. However, a significant challenge in the development of such protein-based medicines is to counter aggregation of the proteins in solution (as these drugs are typically administered by injection). In solution form, aggregation of the normally monomeric protein ingredient affects therapeutic efficiency and reduces shelf life. Moreover, the rapid formation of aggregates in patients during the administration of therapeutic proteins can lead to immunological reactions which could be fatal. Hence, the long term storage of proteins in solution is discouraged. Lyophilization (vacuum drying) is considered to be an effective route for ensuring longer shelf life and better stability of protein therapeutics. However, aggregation can still occur, because the driving forces for aggregation (covalent as well as non-covalent interactions such as hydrogen bonds, van der Waals forces and hydrophobic interactions) are influenced by lyophilization induced changes in the pH, temperature, exposure to interfaces, and dehydration stress. Lyoprotectants such as sugars can counter the undesirable consequences of lyophilization depending upon their nature and potential. Several mechanisms have been proposed for the role of the lyoprotectants. The comprehensive investigation into the inherent nature and influence of lyoprotectants on a protein therapeutic during lyophilization is hence important. In this project an attempt has been made to develop a novel nanoscale screening methodology for the detection, quantification, characterization and prevention of protein aggregation. Initially, ferritin and then a polyclonal IgG (antiglucose-6-phospate dehydrogenase antibody) antibody have been used as model proteins for these studies. The effect of lyophilization on the level of aggregation of IgG was studied and compared to reports in the literature. IgG was exposed to seven cycles of lyophilization, where each cycle of lyophilization was followed by reconstitution and characterization. IgG was also lyophilized with different excipients (sucrose and mannitol, alone and in combination) in different molar ratios. In the liquid state, the formulations were characterized on the basis of particle size and antigen binding activity, whereas in the dry powdered form, the formulations were characterized by studying morphology, thermal stability, and secondary structural alterations in order to establish a relationship amongst the indicated properties. Atomic force microscopy (AFM), dynamic light scattering (DLS) and single particle tracking (Nanosight) were used to study particle size. The identification of different components at the nanoscale and general morphology were screened by AFM and scanning electron microscopy (SEM). Subsequently, the thermal properties and structural alterations respectively were analysed by differential scanning calorimetry (DSC) and infra read spectroscopy (ATR-FTIR) spectroscopy. The antigen binding activity was investigated by performing an indirect ELISA assay on the lyophilized formulations. Lyophilization of ferritin and IgG caused a significant decrease in the proportion of monomeric species was confirmed by AFM, DLS and Nanosight. Dimeric, lower-multimeric and larger aggregates existed in variable proportions for both ferritin and IgG. Powdered lyophilized ferritin formulations showed aggregation, increased crystallinity (concomitant decrease in amorphicity), porosity and flakiness which in case of IgG increased with repeated lyophilization. A consistent increase in the extent of aggregation (unfolding of Fabs and Fc) was detected by DSC and an increase in the beta-sheet structure coupled with structural re-arrangement within the components by ATR-FfIR. The presence of sucrose in IgG formulations resulted in reduced aggregation and enhanced porosity. The inclusion of Mannitol promoted crystallinity, decreased porosity when used alone, however, improved the efficiency of sucrose in combined formulations. The nature of crystals formed by mannitol during lyophilization was shown by SEM and confirmed by AFM. The data obtained from DLS, NTA, AFM, DSC,ATR, and SEM was consistent with by ELISA results which indicated a significant fall in IgG activity upon repeated lyophilization, and improvement in the activity when IgG was formulated with sucrose, which significantly enhanced in combination with mannitol. The benchmark provided by this work would serve as a precursor for developing a novel screening standard for optimizing and improving the therapeutic efficiency of other proteins besides furnishing a detailed account of the disparity in correlating the data from multiple novel techniques. The findings of our work can be directly translated to biotech and biopharm industries for the enhancement of protein based therapeutics.
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Budd, Patrick G. "Implementation and optimisation of alternative therapeutics for use in Clostridium sporogenes as a delivery vehicle." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/39988/.

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Clostridium sporogenes is part of a highly diverse group of Gram positive, spore forming, anaerobic bacteria. C. sporogenes can be used as a delivery vehicle for chemotherapeutics in cancer treatment due to the inactive spore form of C. sporogenes only germinating in the microenvironment of the hypoxic tumour. Cancer, despite large investment in treatment and diagnosis, still remains one of the leading causes of death in the world. As such, improvements on current treatments are necessary to improve patient prognosis. Utilising C. sporogenes could be a cheap and effective way to do this by utilising their germination properties to deliver anti-cancer therapeutics directly to the hypoxic regions of solid tumours. Through introducing Prodrug Converting Enzymes (PCEs) into C. sporogenes when the spores germinate in the tumour the production of the PCE will result in the breakdown of a Prodrug into a toxic product resulting in an anti-cancer effect. This system is known as Clostridial Directed Enzyme Prodrug Therapy (CDEPT). Previous iterations of this system incorporated a nitroreductase gene, used for the breakdown of the prodrug CB1954. During this project alternative prodrugs were investigated, in this case carboxypeptidase G2. Alternatives into the prodrug and enzyme system are also being investigated in a direct action therapy in the form of the monoclonal anti-VEGF. The aims of this project were to implement the genes and optimise the activity of the drugs if necessary. It was also necessary to confirm that the bacterium was a non-pathogenic group 1 bacterium through sequencing and annotation of the genome.
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Golden, Isaac, and homstudy@netconnect com au. "The potential value of homoeoprophylaxis in the long-term prevention of infectious diseases, and the maintenance of general health in recipients." Swinburne University of Technology, 2002. http://adt.lib.swin.edu.au./public/adt-VSWT20050228.150047.

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Homoeoprophylaxis (HP) is the use of homoeopathically prepared substances to prevent targeted infectious diseases in recipients. Its first use in an epidemic of Scarlet Fever was documented in 1801. It has been used throughout the world since then for both short-term and long-term preventative purposes. The effectiveness and safety of Golden�s long-term HP program using homoeopathically prepared substances to prevent targeted infectious diseases in recipients was tested through two research projects. The effectiveness of the program could not be established with statistical certainty given the limited sample size and the low probability of acquiring an infectious disease. However, a possible level of effectiveness of 90.3% was identified subject to specified limitations. Further research to confirm the effectiveness of the program is justified. Statistically significant results were obtained that confirmed the safety of the program both in absolute terms as well as compared to all other methods of disease prevention studied. It also appeared possible that a national immunisation system where both vaccination and HP were available to parents would increase the national coverage against targeted infectious diseases, and reduce the incidence of some chronic health conditions, especially asthma.
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Pontefract, Sarah Katie. "The impact of computerised physician order entry with integrated clinical decision support on pharmacist-physician communication in the hospital setting." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8167/.

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An analysis of over 34,000 free-text messages assigned by pharmacists to prescription orders over a 12-month period showed a sub-optimal exchange of information with the physician. Focus groups and observational research were conducted to provide a more in-depth understanding of the factors involved. The use of CPOE did not reduce opportunities for personal interaction. The capability to communicate electronically facilitated a non-interruptive workflow, beneficial for staff time and for limiting distractions. It also improved clinical documentation, which helped coordinate care of patients between members of the pharmacy team. However, the research identified several barriers to the effectiveness of communication via the CPOE system, including: the increased frequency of messages sent; poor display characteristics of the message; poor access to information to inform decision-making; one-way communication; and no assigned responsibility to respond. These factors need to be considered in the design of systems and supported by interprofessional training to optimise communication between the professionals.
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Hamilton, A. R. "The development and evaluation of antibacterial polymer-phyllosilicate composite systems for the treatment of infected wounds." Thesis, Liverpool John Moores University, 2017. http://researchonline.ljmu.ac.uk/7684/.

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Clays and clay minerals (phyllosilicates) have been used for millennia to treat a range of human maladies, such as infected wounds and diseases of the skin. The unique chemistry of phyllosilicates allows them to support the wound environment and encourage healing. Their physicochemical properties can also be utilised to develop modified drug-release formulations and also enables their incorporation into polymer matrices for the development of advanced wound care materials. By developing novel antibacterial phyllosilicate-polymer composite materials it should be possible to support wound healing, whilst simultaneously treating infections locally to avoid systemic adverse effects and prevent the development of antimicrobial resistance. In this research project the clay minerals kaolin (KN), refined montmorillonite (rMMT), montmorilonite K10 (MMTK10), Laponite® RD (LRD), and Laponite® XL21 (LXL21) were investigated for their differing structure and physicochemical properties. Their ability to adsorb and desorb the antibacterial agents tetracycline (TC), doxycycline (DC) and ciprofloxacin (CIP) was determined through a series of adsorption kinetics and isotherm studies. LRD and LXL21 were shown to have the highest drug-carrying capacity and were also able to relinquish this drug-load to inhibit the proliferation of key wound pathogens; Staphylococcus epidermidis, Propionibacterium acnes, and Pseudomonas aeruginosa. XRD and FTIR analyses demonstrated that these drug molecules could be adsorbed into the interlayer space and edge groups of the Laponite® particles. LXL21-CIP composites were successfully incorporated into alginate polymer matrices through interaction of the exposed edge-groups on LXL21 and the hydroxyl groups of the alginate to produce novel nanocomposite film and foam materials. Selection of candidate materials was initially undertaken qualitatively with the support of a tissue viability nurse at the Royal Liverpool and Broadgreen University Hospitals NHS Trust. Important properties for wound-dressings such as adsorptive capacity, water vapour transmission rate, and keratinocyte compatibility were measured quantitatively and compared to materials already used for wound care in the UK. Both the film and foam materials were shown to have properties that would be beneficial for wound healing and were also able to release CIP in a controlled manner with notable activity against S. epidermidis, P. acnes, and P. aeruginosa. The nanocomposite film formulation developed in this research project showed promise for future clinical applications and future work should be undertaken to further optimise their manufacture and fully characterise their ability to support the healing of infected wounds. Although the nanocomposite foams require further research, the work presented in this thesis suggests they could also be promising materials for wound care applications.
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Dougall, Paul W. R. "Investigation into the effect of formulation on intravenous lipid emulsion metabolism using a novel in vitro fluorescent assay." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/33733/.

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Intravenous lipid emulsions are used ubiquitously through the medical field as a source of parenteral nutrition. Development of new formulations requires an understanding of the metabolism of the product. Current methods of rate determination and of metabolism analysis have several drawbacks. Radioactive labelled assays have lower biological relevance, are time consuming due to separation steps and require long substrate preparation. Existing fluorescence assays based around triglyceride hydrolysis are impractical in emulsion systems due to high signal-noise ratio as well as the use of non-specific fluorescent dyes. Colorimetric methods such as the non-esterified fatty acids (NEFA) assay is expensive, requires multiple steps and specialised machinery. Due to the limitations of these techniques we developed a novel fluorescent assay using a lipoprotein lipase specific substrate incorporated into lipid emulsions. The lipoprotein lipase substrate, EnzChek® Lipase Substrate, green fluorescent, 505/515, is based on a triglyceride structure with a fluorescent dye at the Sn1 position and a dark quencher at the Sn2 position. LPL cleaves preferentially at the Sn1 position of triglycerides, which separates the dye from the quencher creating a fluorescent signal. The signal can then be detected using a fluorescent plate reader. Both lipid emulsion particles and EnzChek are substrates for LPL, so the hydrolysis of EnzChek is analogous for native emulsions particles. Over time, in the presence of LPL, fluorescent signal increases as more EnzChek is hydrolysed in tandem with emulsion particles. We have designed a range of emulsions with varied oil and surfactant composition. Using the EnzChek emulsion assay detailed above we are able to follow the rate of metabolism in real-time. This assay has been tested and found to be robust and reproducible. It is able to investigate differences in metabolism between Soybean oil, medium-chain triglyceride and fish oil emulsions. As well as changes in surfactant type and concentration.
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Lee, Jong Bong. "Optimisation of treatment of cancer based on principles of pharmacokinetics." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/50236/.

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The main hypothesis of this research project was that optimisation of treatment based on pharmacokinetic principles is on its own a powerful approach in improvement of treatment outcomes. This work therefore focused on optimisation of treatment of cancer based on principles of pharmacokinetics using two main approaches 1) lipophilic prodrug approach to specifically target the intestinal lymphatic system following oral administration and 2) identification of orally bioavailable candidate anticancer agents and biopharmaceutical development to increase the bioavailability for sufficient systemic exposure to the drug. The first approach was the prodrug derivatisation to take advantage of the physiological process of intestinal lymphatic transport in order to deliver anticancer agents to the mesenteric lymph nodes. Similar prodrug approaches have been researched by other groups but the main focus previously was on increasing the overall bioavailability where they mostly used long-chain or triglyceride mimetic prodrug moieties. However, in this project, through a series of stability and chylomicron association studies, it was revealed that activated ester prodrugs are the most suitable forms for yielding high concentrations of active drugs in the mesenteric lymph nodes. It was remarkable that using this novel approach significantly higher concentrations of the active drugs were achievable in the intestinal lymphatics without affecting the systemic exposure. The second approach taken in this PhD project was achieving sufficient systemic exposure of anticancer agents by identification of orally bioavailable candidate and improvement of oral bioavailability by biopharmaceutical development. The candidates with promising pharmacokinetic properties were rank-ordered by application of a rational drug discovery and development approach of integrated in vitro-in silico assessments. Following in vivo confirmation studies, oral bioavailability was further enhanced for a compound that exhibited a double-peak phenomenon. The results of the two approaches indicate that pharmacokinetic optimisation can be useful in development of anticancer agents to improve the treatment outcomes of cancer.
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Marsh, Georgina E. "Utilising micron-scale 3D printing to investigate particulate interactions for respiratory applications." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/50247/.

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In order to achieve drug delivery via the respiratory route, an understanding of particulate interactions is of vital importance. For successful delivery to the distal airways, an aerodynamic diameter of less than 5 μm must be achieved. However, particles of this size presents a difficult formulation challenge, due to the inherent cohesiveness between particles and adhesion to the device, due to the high surface to volume ratio of such small particles, causing the particles to clump together. This tendency will thereby cause a reduction in dispersion, aerosolisation and device efficiency; for this reason dry powder inhalers (DPIs) invariably fail to achieve a fine particle fraction efficiency above 15%. There are a wide variety of factors which affect particulate interactions including; surface roughness, surface chemistry, particle size or shape and particle mechanical properties. However, these factors are highly interrelated and so previous attempts to investigate their effect on particle adhesion generally have difficulty isolating the impact of each factor. For instance, investigating the effect of morphology on particulate interactions invariably utilise destructive techniques to alter the roughness, which is likely to alter other factors like surface energy and provide limited control for optimisation. With the rise of 3D printing (additive manufacturing) there is now the capability to produce sub- micron morphologies, and so a bottom-up approach to studying the effect of morphology on particulate interactions can be achieved. The aims of this thesis are therefore twofold. Firstly, to identify, optimise and evaluate a suitable additive manufacturing technique to produce well-defined micron scale morphologies appropriate for furthering the understanding of the importance of morphology on particle adhesion. This is a scale which is at least two orders of magnitude improvement on current state of the art 3D inkjet printers. Secondly, to measure the effect on particle adhesion and deposition to these morphologies, both on an individual particle and on a bulk powder basis, allowing elucidation and understanding of the effect of surface roughness on particle adhesion, with a specific focus on respiratory drug delivery. Printing well defined geometries of an appropriate micron scale size range for particle adhesion testing has been achieved, using two photon polymerisation (TPP). TPP is a novel 3D printing technique which as its name suggests involves the curing of usually acrylate containing polymer resins by the absorption of two infra-red photons in the focus of the laser beam. TPP has been shown to produce a sub-diffraction limit lateral resolution of 120 nm. By optimising the printer parameters and experimentation with differing structure fill and input settings the creation of a well- defined curve on a micron scale was achieved. The initial test morphologies comprised of a ridge with a semi-circular top with a diameter of 1 μm, which were shown to be reproducibly printed. These morphologies were then varied in a controllable fashion with varying ridge height and spacing between the ridges. A uniform and consistent surface chemistry was created using a plasma polymerised hexane (ppHex) coating. In order to evaluate particulate interactions relevant to pulmonary drug delivery both an understanding of the effect of morphology on both individual particle adhesion and bulk powder deposition in a fluid environment is needed. Individual particle-surface adhesion was achieved by testing the TPP structures against three particle types using single particle colloidal probe microscopy (polystyrene beads diameter 10 μm and 5 μm and a lactose particle designed for inhalation formulations). The analysis of this data provides evidence of a clear trend between particle contact area and adhesion recorded both on the ppHex control and the TPP coated morphologies. The TPP morphologies are shown to locally reduce the overall adhesion, in comparison to the flat substrate. The ridge height is also seen to have a significant effect on particle adhesion, with 5 μm < 3 μm < 1 μm for the polystyrene beads, but 3 μm < 5 μm < 1 μm for the Respitose SV003 lactose particle for all ridge spacings. Varying the ridge spacing produced two differing trends in adhesion to the polystyrene beads. If the particle was unable to penetrate the valleys of the roughness, for the 1 μm high ridges, a significant effect on particle adhesion was seen with 3 μm < 1 μm for the polystyrene beads. In contrast, the 3 μm and 5 μm high ridges showed the opposite trend when the particle is unable to descend between the ridges with 1 μm < 3 μm < 8 μm for the polystyrene beads. Investigation of the bulk powder deposition of the particles on the TPP structures and any subsequent re-entrainment in a fluid environment was then achieved using a novel methodology developed during the course of this work. This combines the use of a standard next generation impactor, which generally is used to separate out a respiratory formulation based on aerodynamic diameter, with the TPP substrates. This shows that ridge height has a significant effect on particle adhesion with 3 μm < 1 μm < 5 μm. In contrast, the different spacings of the ridges were not shown to produce a significant difference in particle deposition. This is likely due to the conflicting effect of asperity spacing on the processes of particle deposition and re-entrainment. This thesis therefore highlights the capability of TPP, to produce well-defined micron scale structures with varying morphologies. It then shows that these can be successfully utilised to provide valuable insight into the effect of surface morphology on particle- surface interactions, specifically; adhesion, deposition and re-entrainment.
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Books on the topic "Materia medica and therapeutics"

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Samuel. Materia medica pura. New Delhi: Jain, 1995.

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Cand, Māthur Kishan, ed. Urdu materia medica: Pharmacology and therapeutics. 1921,st.chuna mandi,paharganj: b.jain, 1994.

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Khory, Rustomjee Naserwanjee. Materia medica of India and their therapeutics. Delhi: Komal Prakashan, 1999.

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Pereira, Jonathan. The elements of materia medica and therapeutics. Cambridge, UK: Cambridge University Press, 2014.

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Kent, James Tyler. Materia medica of homoeopathic remedies. 2nd ed. London: Homoeopathic Book Service, 1989.

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Vithoulkas, George. Essence of materia medica. New Delhi: B. Jain, 1988.

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Kent, James Tyler. Materia medica of homoeopathic remedies. 2nd ed. London: Homoeopathic Book Service, 1989.

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Bensky, Dan. Chinese herbal medicine: Materia medica. Seattle: Eastland Press, 1986.

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Mooney, Jean. Lecture notes on pharmacology, materia medica and therapeutics. 2nd ed. London: Chelsea School of Chiropody, 1989.

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Bruce, John Mitchell. Materia Medica and Therapeutics. Creative Media Partners, LLC, 2018.

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Book chapters on the topic "Materia medica and therapeutics"

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Carlson, David Lee, and James Albright. "Materia Medica." In Composing a Care of the Self, 1–32. Rotterdam: SensePublishers, 2012. http://dx.doi.org/10.1007/978-94-6209-022-4_1.

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Stolberg, Michael. "Materia medica." In Gabrielle Falloppia, 1522/23–1562, 113–32. London: Routledge, 2022. http://dx.doi.org/10.4324/9781003242000-5.

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Mûrî al-Hâlidi, M., and Martin Levey. "Samarkaddi's materia medica." In al-Machriq, edited by Louis Cheikho, 411–20. Piscataway, NJ, USA: Gorgias Press, 2014. http://dx.doi.org/10.31826/9781463232146-023.

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Gupta, Pankaj, Vijay Kumar Sharma, and Sushma Sharma. "Indigenous Materia Medica." In SpringerBriefs in Environmental Science, 121–35. New Delhi: Springer India, 2014. http://dx.doi.org/10.1007/978-81-322-1925-5_6.

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Steger, Florian. "Dioskurides, Pedanios: Materia medica." In Kindlers Literatur Lexikon (KLL), 1–2. Stuttgart: J.B. Metzler, 2020. http://dx.doi.org/10.1007/978-3-476-05728-0_11874-1.

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Ye, Huagu. "Correction to: Common Chinese Materia Medica – Volume 7." In Common Chinese Materia Medica, C1. Singapore: Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-5900-3_11.

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Ye, Huagu. "Correction to: Common Chinese Materia Medica – Volume 4." In Common Chinese Materia Medica, C1. Singapore: Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-5884-6_11.

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Ye, Huagu. "Correction to: Common Chinese Materia Medica – Volume 6." In Common Chinese Materia Medica, C1. Singapore: Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-5892-1_11.

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Ye, Huagu. "Correction to: Common Chinese Materia Medica – Volume 3." In Common Chinese Materia Medica, C1. Singapore: Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-5880-8_11.

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Ye, Huagu. "Correction to: Common Chinese Materia Medica – Volume 9." In Common Chinese Materia Medica, C1. Singapore: Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-5920-1_11.

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Conference papers on the topic "Materia medica and therapeutics"

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Subekti, Hasan, Herawati Susilo, Ibrohim Ibrohim, Hadi Suwono, and Aris Rudi Purnomo. "Exploration of Balai Materia Medica Batu: Field-Trip Supporting Biotechnology Learning." In Proceedings of the Mathematics, Informatics, Science, and Education International Conference (MISEIC 2019). Paris, France: Atlantis Press, 2019. http://dx.doi.org/10.2991/miseic-19.2019.44.

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Tao, Yu. "Research on visual design and interactive realization of Compendium of Materia Medica." In ICIEAI 2023: 2023 International Conference on Information Education and Artificial Intelligence. New York, NY, USA: ACM, 2023. http://dx.doi.org/10.1145/3660043.3660220.

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Bing Chen, Xuchu Weng, Beizhan Wang, and Xueqin Hu. "Analysis and solution of data quality in data warehouse of Chinese materia medica." In Education (ICCSE). IEEE, 2009. http://dx.doi.org/10.1109/iccse.2009.5228165.

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Weigang Duan, Ling Que, Jin Ke, Qifeng Li, Luyong Zhang, and Zhengzhou Jiang. "Detection of trace protein in Chinese Materia Medica injections by soaking PVDF membrane." In 2011 International Conference on Remote Sensing, Environment and Transportation Engineering (RSETE). IEEE, 2011. http://dx.doi.org/10.1109/rsete.2011.5965902.

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Block, Janice. "19th Century Homeopathic Materia Medica Texts Predict Source Materials Whose Physiology Influences Thyroid Activity." In HRI London 2019—Cutting Edge Research in Homeopathy: Presentation Abstracts. The Faculty of Homeopathy, 2020. http://dx.doi.org/10.1055/s-0040-1702099.

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Ciocanel, Alexandra, Razvan Rughinis, and Cosima Rughinis. "DIGITAL TECHNOLOGY AND BOUNDARY WORK IN HOMEOPATHY." In eLSE 2017. Carol I National Defence University Publishing House, 2017. http://dx.doi.org/10.12753/2066-026x-17-250.

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In this paper we examine the evolving roles of digital technology in shaping the professional identity and therapeutic encounters of homeopathic practitioners. Homeopathy is a form of alternative medicine that relies almost exclusively in making a diagnostic on patients’ verbal description of their symptoms. In contrast to the biomedical diagnosis, the homeopathic diagnosis does not place the patient in a disease category, but in a remedy category. The software that aids homeopathic professionals in their practice is based on a digitalization of books that organized the homeopathic knowledge of remedies and symptoms (repertories and Materia Medica). Organized as an inventory of descriptions of remedies and symptoms, the software operates algorithmically in helping the homeopath to match patients’ symptoms to possible remedies and select the most adequate remedy. During the consultation, the homeopath makes a patient file by writing a selection of words extracted from patients’ talk that express symptoms in great detail – including feelings, signs of suffering and various lifestyle preferences. In this process the homeopath and the software co-create the patient’s “person” as a collection of more-or-less idiosyncratic symptoms, in their attempt to match the patient’s symptomatology with the description of one single remedy. Drawing on interviews with patients and homeopaths, observations of consultations and homeopathic seminars, we argue that the use of digital technology is practiced as boundary work. Firstly, digital technology becomes a boundary marker between the patient and the homeopath. Secondly, digital technology helps homeopaths to legitimize their practice as a rigorous one, being one of the strategies used to gain acceptance in the health-care ecosystem. Last but not least, by presenting the software as only a time-saving device, a neutral aide for making “intelligent suggestions” that can be confirmed but also rejected by the homeopath’s judgment, homeopaths create a distinct professional identity oriented around a central principle of their practice: “Treat the patient as a whole person”.
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Choy, S. K., and C. S. Tong. "A Correlated Bit-Plane Model for Wavelet Subband Histograms and Its Application to Chinese Materia Medica Starch Grains Classification." In 2007 Third International IEEE Conference on Signal-Image Technologies and Internet-Based System SITIS. IEEE, 2007. http://dx.doi.org/10.1109/sitis.2007.78.

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Yang, Tianqi, Shimin Zhang, and Yuqing Li. "A Study on the Distribution and Influencing Factors of the Origin of Plant Herbs in Compendium of Materia Medica." In 2022 IEEE International Conference on Bioinformatics and Biomedicine (BIBM). IEEE, 2022. http://dx.doi.org/10.1109/bibm55620.2022.9995305.

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Tse, Zion Tsz Ho, Alexander Squires, and John Oshinski. "Robot for MRI-Guided ALS Spinal Therapy." In 2017 Design of Medical Devices Conference. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/dmd2017-3527.

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Limited treatment options are available for treating Amyotrophic Lateral Sclerosis (ALS) (1). Small animal models have shown promise in halting neurodegeneration associated with ALS where cellular therapeutics are delivered to the ventral horn of the spinal cord (2), although this procedure is invasive and requires multi-level laminectomy and dissection of the dura mater (Fig. 1). We hypothesized that SpinoBof, a robotic needle guidance platform (Fig. 2) could deliver cellular therapeutics to the ventral horn percutaneously under MRI guidance, enhancing upon existing invasive and time-consuming techniques for targeting injection sites.
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Chahine, Nadeen O., Nicole M. Collette, Heather Thompson, and Gabriela G. Loots. "Application of Carbon Nanotubes in Cartilage Tissue Engineering." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-192494.

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Carbon nanotubes (CNTs) are cylindrical allotropes of carbon that are nanometers in diameter and posses unique physical properties, positioning them as ideal materials for studying physiology at a single cell level. CNTs have the potential to become a very important component of medical therapeutics, likely acting as (a) drug delivery system [1], (b) existing as an interfacial layer in surgical implants [2,3], or (c) acting as scaffolding in tissue engineering [4,8]. While some studies have explored the use of CNTs as a novel material in regenerative medicine, they have not yet been fully evaluated in cellular systems. One major limitation of CNTs that must be overcome is their inherent cytotoxicity. The goal of this study is to assess the long-term biocompatibility of CNTs for chondrocyte growth. We hypothesize that CNT-based material in tissue engineering can provide an improved molecular sized substrate for stimulation of cellular growth, and structural reinforcement of the scaffold mechanical properties. Here we present data on the effects of CNTs on chondrocyte viability and biochemical deposition examined in composite materials of hydrogels + CNTs mixtures. Also, the effects of CNTs surface functionalization with polyethlyne glycol (PEG) or carboxyl groups (COOH) were examined.
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Reports on the topic "Materia medica and therapeutics"

1

Grace, Dr Golla Reethi Shiny, Dr Anu K., Dr Pratyusha Choudary G., and Dr M. v. PATTERN OF THE HEMATOLOGICAL PARAMETERS IN COVID-19 PATIENTS. World Wide Journals, February 2023. http://dx.doi.org/10.36106/ijar/5106302.

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Background: The coronavirus (SARS CoV 2)-related viral disease COVID 19 causes acute respiratory disease with severe symptoms. Numerous biomarkers of infection and inammation have been found to inuence the severity of disease. Acute respiratory infection, fever, pneumonia, cough, tiredness, and inammation are frequent clinical ndings during hospitalisation. The severity of the disease and a possibility of disease progression can be determined by circulating biomarkers like TWBC count, NLR and CRP that reect inammation. This is a retrospective study conducted on eight Material and Methods: y COVID-19 positive patients admitted at Dr.Pinnamaneni Siddhartha Institute of Medical Sciences & RF, ChinnaAvutapally from 1st January 2021 to 30th June 2021. Results: Among the 80 COVID 19 patients studied, there are 63% males and 37% females. 46% of patients showed leucocytosis, 43% showed increased NLR and 60 % showed raised CRP. Hematological parameters in COVID 19 are important for di Conclusion: agnosis, complication management, prognosis, and patient recovery. These parameters must be effectively integrated into clinical algorithms and therapeutic decision making in addition to clinical assessment
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