Relevant bibliographies by topics / MATE transporter

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Academic literature on the topic 'MATE transporter'

Author: Grafiati
Published: 4 June 2021
Last updated: 7 February 2022

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Journal articles on the topic "MATE transporter"

1

Goda, Mitsuhiro, Kana Oda, Atsuko Oda, Naoki Kobayashi, and Masato Otsuka. "Involvement of the Multidrug and Toxic Compound Extrusion Transporter in Testosterone Release from Cultured Pig Leydig Cells." Pharmacology 100, no. 1-2 (2017): 31–39. http://dx.doi.org/10.1159/000460822.

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Testosterone is considered to be released from Leydig cells via passive diffusion because of its hydrophobicity; however, the exact mechanism underlying testosterone secretion and the transporter involved are both unknown. Multidrug and toxic compound extrusion (MATE) transporters are predominantly found in the kidneys and liver and are thought to function in the elimination of metabolic organic cations during the final step of excretion in the kidney. In contrast, mMATE2 has been shown to be predominantly expressed in testicular Leydig cells. Although the physiological function of mMATE2 in Leydig cells is unknown, we hypothesized that mMATE2 acts as a testosterone exporter and is responsible for the secretion of testosterone from Leydig cells. Therefore, in the present study, we investigated the involvement of the MATE transporter in testosterone secretion from pig Leydig cells. Immunohistochemical analysis with anti-pig MATE2 antiserum indicated that the MATE transporter is present in pig Leydig cells. Additionally, treatment with the MATE inhibitors cimetidine and pyrimethamine reduced the testosterone secretion from pig Leydig cells but increased the intracellular testosterone levels. Estradiol release and intracellular estradiol level induced by human chorionic gonadotropin (hCG) further increased with cimetidine treatment. These results indicated that testosterone produced by hCG treatment is secreted from Leydig cells via the MATE transporter; however, in the presence of cimetidine or pyrimethamine, this MATE transporter-mediated secretion was inhibited, resulting in increased intracellular testosterone levels and estradiol production in Leydig cells. Thus, the MATE transporter may be responsible for testosterone secretion from Leydig cells.
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Tocci, Nadia, Francesco Iannelli, Alessandro Bidossi, Maria Laura Ciusa, Francesca Decorosi, Carlo Viti, Gianni Pozzi, Susanna Ricci, and Marco Rinaldo Oggioni. "Functional Analysis of Pneumococcal Drug Efflux Pumps Associates the MATE DinF Transporter with Quinolone Susceptibility." Antimicrobial Agents and Chemotherapy 57, no. 1 (October 31, 2012): 248–53. http://dx.doi.org/10.1128/aac.01298-12.

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ABSTRACTThe pneumococcal chromosome encodes about 140 transporters, many of which are predicted to be involved in efflux. In order to critically evaluate pneumococcal efflux, a series of transporter mutants were constructed, and their phenotypes were assayed by disk diffusion, microdilution drug susceptibility testing (MIC testing), growth of cultures at sub-MIC concentrations, and phenotype microarray analysis. Mutants with mutations in seven ATP binding cassette (ABC) transporters, three multiantimicrobial extrusion (MATE) family efflux pumps, and one major facilitator superfamily (MFS) transporter were obtained inStreptococcus pneumoniaestrain DP1004. The susceptibility of these 11 mutants to over 250 different substances was compared to that of the parent strain. Of the tested transporters, only the ABC transporter PatAB (SP2073-5) presented a clear multidrug resistance (MDR) profile, as the mutant showed significantly increased susceptibility to ethidium bromide, acriflavine, and berberine. Among the other transporters analyzed, the mutants devoid of the MATE efflux pump SP2065 exhibited reduced susceptibility to novobiocin, and those with mutations of the MATE family DinF transport system (SP1939) exhibited increased susceptibility to moxifloxacin, ciprofloxacin, and levofloxacin. This change in quinolone MIC was found to be independent from the competence-mediated effect of quinolones on thecinA-recA-dinFoperon. Furthermore, thedinFmutant, in contrast to the parental strain, allowed selection for quinolone-resistant mutants when exposed to moxifloxacin. These data confirm the clear MDR profile of the PatAB ABC transporter and suggest for the MATE DinF a phenotype associated with quinolone susceptibility, particularly for moxifloxacin.
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Zakrzewska, Sandra, Ahmad Reza Mehdipour, Viveka Nand Malviya, Tsuyoshi Nonaka, Juergen Koepke, Cornelia Muenke, Winfried Hausner, Gerhard Hummer, Schara Safarian, and Hartmut Michel. "Inward-facing conformation of a multidrug resistance MATE family transporter." Proceedings of the National Academy of Sciences 116, no. 25 (June 3, 2019): 12275–84. http://dx.doi.org/10.1073/pnas.1904210116.

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Multidrug and toxic compound extrusion (MATE) transporters mediate excretion of xenobiotics and toxic metabolites, thereby conferring multidrug resistance in bacterial pathogens and cancer cells. Structural information on the alternate conformational states and knowledge of the detailed mechanism of MATE transport are of great importance for drug development. However, the structures of MATE transporters are only known in V-shaped outward-facing conformations. Here, we present the crystal structure of a MATE transporter from Pyrococcus furiosus (PfMATE) in the long-sought-after inward-facing state, which was obtained after crystallization in the presence of native lipids. Transition from the outward-facing state to the inward-facing state involves rigid body movements of transmembrane helices (TMs) 2–6 and 8–12 to form an inverted V, facilitated by a loose binding of TM1 and TM7 to their respective bundles and their conformational flexibility. The inward-facing structure of PfMATE in combination with the outward-facing one supports an alternating access mechanism for the MATE family transporters.
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Väisänen, Enni, Junko Takahashi, Ogonna Obudulu, Joakim Bygdell, Pirkko Karhunen, Olga Blokhina, Teresa Laitinen, et al. "Hunting monolignol transporters: membrane proteomics and biochemical transport assays with membrane vesicles of Norway spruce." Journal of Experimental Botany 71, no. 20 (August 10, 2020): 6379–95. http://dx.doi.org/10.1093/jxb/eraa368.

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Abstract Both the mechanisms of monolignol transport and the transported form of monolignols in developing xylem of trees are unknown. We tested the hypothesis of an active, plasma membrane-localized transport of monolignol monomers, dimers, and/or glucosidic forms with membrane vesicles prepared from developing xylem and lignin-forming tissue-cultured cells of Norway spruce (Picea abies L. Karst.), as well as from control materials, comprising non-lignifying Norway spruce phloem and tobacco (Nicotiana tabacum L.) BY-2 cells. Xylem and BY-2 vesicles transported both coniferin and p-coumaryl alcohol glucoside, but inhibitor assays suggested that this transport was through the tonoplast. Membrane vesicles prepared from lignin-forming spruce cells showed coniferin transport, but the Km value for coniferin was much higher than those of xylem and BY-2 cells. Liquid chromatography-mass spectrometry analysis of membrane proteins isolated from spruce developing xylem, phloem, and lignin-forming cultured cells revealed multiple transporters. These were compared with a transporter gene set obtained by a correlation analysis with a selected set of spruce monolignol biosynthesis genes. Biochemical membrane vesicle assays showed no support for ABC-transporter-mediated monolignol transport but point to a role for secondary active transporters (such as MFS or MATE transporters). In contrast, proteomic and co-expression analyses suggested a role for ABC transporters and MFS transporters.
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Kusakizako, Tsukasa, Yoshiki Tanaka, Christopher J. Hipolito, Teruo Kuroda, Ryuichiro Ishitani, Hiroaki Suga, and Osamu Nureki. "LCP crystallization and X-ray diffraction analysis of VcmN, a MATE transporter fromVibrio cholerae." Acta Crystallographica Section F Structural Biology Communications 72, no. 7 (June 22, 2016): 552–57. http://dx.doi.org/10.1107/s2053230x16008931.

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Multidrug and toxic compound extrusion (MATE) transporters, one of the multidrug exporter families, efflux xenobiotics towards the extracellular side of the membrane. Since MATE transporters expressed in bacterial pathogens contribute to multidrug resistance, they are important therapeutic targets. Here, a MATE-transporter homologue fromVibrio cholerae, VcmN, was overexpressed inEscherichia coli, purified and crystallized in lipidic cubic phase (LCP). X-ray diffraction data were collected to 2.5 Å resolution from a single crystal obtained in a sandwich plate. The crystal belonged to space groupP212121, with unit-cell parametersa= 52.3,b= 93.7,c= 100.2 Å. As a result of further LCP crystallization trials, crystals of larger size were obtained using sitting-drop plates. X-ray diffraction data were collected to 2.2 Å resolution from a single crystal obtained in a sitting-drop plate. The crystal belonged to space groupP212121, with unit-cell parametersa= 61.9,b= 91.8,c= 100.9 Å. The present work provides valuable insights into the atomic resolution structure determination of membrane transporters.
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Chen, Jing, Yuji Morita, M. Nazmul Huda, Teruo Kuroda, Tohru Mizushima, and Tomofusa Tsuchiya. "VmrA, a Member of a Novel Class of Na+-Coupled Multidrug Efflux Pumps from Vibrio parahaemolyticus." Journal of Bacteriology 184, no. 2 (January 15, 2002): 572–76. http://dx.doi.org/10.1128/jb.184.2.572-576.2002.

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ABSTRACT Gene vmrA, cloned from Vibrio parahaemolyticus, made Escherichia coli resistant to 4prime;,6-diamino-2-phenylindol, tetraphenylphosphonium chloride, acriflavine, and ethidium bromide. VmrA belongs to the DinF branch of MATE family efflux transporters. VmrA catalyzed acriflavine efflux and showed Na+/drug transporter activity because the addition of tetraphenylphosphonium to Na+-loaded cells caused Na+ efflux.
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Freitas-Lima, Leandro Ceotto, Alexandre Budu, Adriano Cleis Arruda, Mauro Sérgio Perilhão, Jonatan Barrera-Chimal, Ronaldo Carvalho Araujo, and Gabriel Rufino Estrela. "PPAR-α Deletion Attenuates Cisplatin Nephrotoxicity by Modulating Renal Organic Transporters MATE-1 and OCT-2." International Journal of Molecular Sciences 21, no. 19 (October 8, 2020): 7416. http://dx.doi.org/10.3390/ijms21197416.

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Cisplatin is a chemotherapy drug widely used in the treatment of solid tumors. However, nephrotoxicity has been reported in about one-third of patients undergoing cisplatin therapy. Proximal tubules are the main target of cisplatin toxicity and cellular uptake; elimination of this drug can modulate renal damage. Organic transporters play an important role in the transport of cisplatin into the kidney and organic cations transporter 2 (OCT-2) has been shown to be one of the most important transporters to play this role. On the other hand, multidrug and toxin extrusion 1 (MATE-1) transporter is the main protein that mediates the extrusion of cisplatin into the urine. Cisplatin nephrotoxicity has been shown to be enhanced by increased OCT-2 and/or reduced MATE-1 activity. Peroxisome proliferator-activated receptor alpha (PPAR-α) is the transcription factor which controls lipid metabolism and glucose homeostasis; it is highly expressed in the kidneys and interacts with both MATE-1 and OCT-2. Considering the above, we treated wild-type and PPAR-α knockout mice with cisplatin in order to evaluate the severity of nephrotoxicity. Cisplatin induced renal dysfunction, renal inflammation, apoptosis and tubular injury in wild-type mice, whereas PPAR-α deletion protected against these alterations. Moreover, we observed that cisplatin induced down-regulation of organic transporters MATE-1 and OCT-2 and that PPAR-α deletion restored the expression of these transporters. In addition, PPAR-α knockout mice at basal state showed increased MATE-1 expression and reduced OCT-2 levels. Here, we show for the first time that PPAR-α deletion protects against cisplatin nephrotoxicity and that this protection is via modulation of the organic transporters MATE-1 and OCT-2.
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Kusakizako, Tsukasa, Yoshiki Tanaka, Andrés Maturana, Christopher Hipolito, Teruo Kuroda, Ryuichiro Ishitani, Hiroaki Suga, and Osamu Nureki. "X-ray crystallographic analysis of a MATE multidrug transporter from V. cholerae." Acta Crystallographica Section A Foundations and Advances 70, a1 (August 5, 2014): C709. http://dx.doi.org/10.1107/s2053273314092900.

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MATE (Multidrug And Toxic compound Extrusion) family transporters are highly conserved from Bacteria to Eukarya including human, and export a broad range of xenobiotics using either a proton or a sodium ion gradient across the membrane. Especially in bacterial pathogens, MATE transporters contribute to their multiple drug resistance (MDR). To understand how MATE transporters export various substrates such as drugs and thus how pathogens acquire MDR, structural analyses are essential. The crystal structures of several MATE transporters from pathogens have been reported. However, because of the limited resolution and the lack of drug-MATE transporters complex structures, the recognition mechanism of various substrates and the coupling mechanism of the cation influx and the drug efflux have been poorly understood. Although the high-resolution structures of MATE transporters from non-pathogenic archaeal P. furiosus (PfMATE) have been reported, PfMATE shares low sequence identity with MATE transporters from pathogens such as V. cholerae. Therefore, further findings of the structural mechanism of MDR caused by MATE transporters from pathogens have been needed. To understand the substrate recognition and transport mechanism of MATE transporters from pathogens, we determined the crystal structures of one of MATE transporters from V. cholerae (VcMATE) at 2.5-2.7 Å resolutions using in meso crystallization method. The high-resolution structures of VcMATE show two distinct conformations, as observed in the structures of PfMATE, and reveal the large movement of transmembrane helix 1 and the putative substrate-binding site. The structures suggest that the bending of transmembrane helix 1 and the sequential collapse of the putative substrate-binding site induce the release of the bound substrate. This conformational change during the substrate transport may be a common mechanism among MATE transporters from pathogens to non-pathogens.
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Dobritzsch, Melanie, Tilo Lübken, Lennart Eschen-Lippold, Karin Gorzolka, Elke Blum, Andreas Matern, Sylvestre Marillonnet, Christoph Böttcher, Birgit Dräger, and Sabine Rosahl. "MATE Transporter-Dependent Export of Hydroxycinnamic Acid Amides." Plant Cell 28, no. 2 (January 7, 2016): 583–96. http://dx.doi.org/10.1105/tpc.15.00706.

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Meyer zu Schwabedissen, Henriette E., Celine Verstuyft, Heyo K. Kroemer, Laurent Becquemont, and Richard B. Kim. "Human multidrug and toxin extrusion 1 (MATE1/SLC47A1) transporter: functional characterization, interaction with OCT2 (SLC22A2), and single nucleotide polymorphisms." American Journal of Physiology-Renal Physiology 298, no. 4 (April 2010): F997—F1005. http://dx.doi.org/10.1152/ajprenal.00431.2009.

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renal elimination of a number of cationic compounds is thought to be mediated by the organic cation transporter 2 (OCT2, SLC22A2), a drug uptake transporter expressed at the basolateral domain of renal tubular cells. Recently, the key efflux transporter for the secretion organic cations was identified as an electroneutral H+/organic cation exchanger termed the multidrug and toxin extrusion (MATE)-type transporter 1 (MATE1, SLC47A1). The key goals of this study were to assess the interplay between the renal cationic transporters OCT2 and MATE1 and the functional assessment of genetic variation in human MATE1. First, the ability of various agents to interact with OCT2- or MATE1-mediated transport was determined using a recombinant vaccinia expression system. We were able to identify several drugs in clinical use with a divergent inhibitory capacity for these transporters. Subsequently, we further assessed the effect of those compounds on the cellular accumulation of shared substrates using OCT2 and MATE1 double-transfected cells. Consistent with data obtained using single transporter transfected cells, compounds that exhibited preferential inhibition of MATE1 such as rapamycin and mitoxantrone induced significant cellular accumulation of cationic substrates. We next assessed the functional relevance of MATE1 genetic polymorphisms. Significant loss of transport activity for metformin and tetraethylammonium was noted for two nonsynonymous single nucleotide polymorphisms (SNPs), c.404T>C (p.159T>M) and c.1012G>A (p.338V>A). The c.404T>C was only seen in Asian subjects with an allele frequency of 1%, and the c.1012G>A SNP was much more common, especially among those of African descent. In conclusion, we show that coordinate function of MATE1 with OCT2 likely contributes to the vectorial renal elimination of organic cationic drugs and that altered activity of MATE1, whether by drugs or polymorphisms, should be considered as an important determinant of renal cationic drug elimination.
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Dissertations / Theses on the topic "MATE transporter"

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Jin, Yoonhee. "Energetics and mechanism of multidrug transport by the MATE transporter NorM from Vibrio cholerae." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648473.

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Pengelly, Jasper John Lobl Biotechnology &amp Biomolecular Sciences Faculty of Science UNSW. "Molecular characterisation of membrane transporters associated with saxitoxin biosynthesis in cyanobacteria." Publisher:University of New South Wales. Biotechnology & Biomolecular Sciences, 2008. http://handle.unsw.edu.au/1959.4/41429.

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The release of the neurotoxic alkaloid saxitoxin by cyanobacterial cells was previously thought to occur primarily after cell lysis, yet recent evidence also suggests active toxin export by membrane transporters. Transporter proteins associated with STX biosynthesis in Cylindrospermopsis raciborskii T3 (sxtF and sxtM) and Anabaena circinalis 131C (naDt) were predicted to be involved in the export of STX from cyanobacterial cells. The main aim of this project was to characterise the transporters associated with STX biosynthesis, by investigation of their genetic prevalence, functional substrates and specific regulation. An sxtM homologue was discovered in A. circinalis 131C, as part of an sxt cluster, and found to be uniquely associated with STX-producing strains. Bioinformatic and phylogenetic analysis showed that the translated sxt transporters clustered with the NorM prokaryotic MATE sub-family and membrane topology analysis predicted 12 membrane-spanning regions. To characterise the functional substrates of the putative STX-transporters, they were heterologously expressed in the antibiotic-sensitive E. coli strain KAM32. Expression of the sxt MATES complemented host sensitivity to the cationic fluroquinolone antibiotics, ciprofloxacin and ofloxacin. Disruption of gene homologues of naDt and the sxt MATE genes in Synechocystis sp. PCC6803 yielded mutant strains with increased sensitivity to the toxic organic cations, methyl viologen and acriflavine. Transcription of the putative STX transporters, and the putative STX biosynthesis gene sxtA, was studied in C. raciborskii T3 and A. circinalis 131C under alkali and Na+ stress. Alkali stress (pH 9) decreased total STX levels in A. circinalis 131C and was correlated with a down-regulation of the putative transport and biosynthetic genes. In C. raciborskii T3, alkali stress promoted higher extracellular but lower intracellular STX levels, which also correlated with large increases in transcription of the putative STX transport genes.
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Zakrzewska, Sandra [Verfasser], Hartmut [Akademischer Betreuer] Michel, Klaas Martinus [Gutachter] Pos, and Hartmut [Gutachter] Michel. "Structural and functional characterization of a MATE family multidrug resistance transporter from "Pyrococcus furiosus" / Sandra Zakrzewska ; Gutachter: Klaas Martinus Pos, Hartmut Michel ; Betreuer: Hartmut Michel." Frankfurt am Main : Universitätsbibliothek Johann Christian Senckenberg, 2020. http://d-nb.info/1208033042/34.

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Chedik, Lisa. "Nature et conséquences des interactions entre transporteurs membranaires et pesticides." Thesis, Rennes 1, 2017. http://www.theses.fr/2017REN1B035/document.

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Les pyréthrinoïdes et les organophosphorés sont des pesticides très utilisés, à l’origine d’une imprégnation forte de la population, exposée à ces contaminants principalement via l’alimentation. De plus en plus d’études scientifiques suggèrent des liens entre l’exposition à ces composés et des maladies chroniques ou des troubles du développement de l’enfant. Paradoxalement, leur devenir biologique chez l’homme est mal connu. Certaines études suggèrent que ces insecticides sont susceptibles d’intéragir avec les transporteurs membranaires ABC et SLC, protéines localisées au niveau d’interfaces hémato-tissulaires qui prennent en charge de nombreux substrats endogènes, médicaments et contaminants de l’environnement. L’objectif de notre étude a été de caractériser les effets d’insecticides des familles des pyréthrinoïdes et des organophosphorés sur l’activité de nombreux transporteurs ABC et SLC prenant en charge des médicaments (P-gp, BCRP, MRPs, OATP-1B1,-2B1,-1B3, OCT1-3, OAT1, OAT3, MATE1 et MATE2K) par une approche in vitro. Nous nous sommes également attachés à caractériser par des expérimentations in vitro et in silico, les mécanismes des interactions et les éléments structuraux des pesticides à l’origine de ces effets. Nous avons montré que de nombreux organophosphorés et pyréthrinoïdes étaient capables d’inhiber des transporteurs d’efflux (MRP, BCRP, P-gp) et d’influx (OATP1B1, OAT3, MATE1, OCT1-2) et de stimuler l’activité de certains OATPs. Les pesticides testés inhibaient très fortement l’activité des transporteurs de cations (OCT1 et OCT2) et ont pu bloquer le transport de catécholamines médiés par ces protéines. Une approche qSAR a permis de définir des paramètres physicochimiques associés aux effets modulateurs des pesticides et une approche d’amarrage moléculaire (docking) a mise en évidence les sites de liaisons de la P-gp impliquées dans ces interactions. Les conséquences des modulations de l’activité des transporteurs, en termes d’effets toxiques et d’interactions médicamenteuses, restent à définir pour les populations exposées à de fortes doses de pesticides. Toutefois, la contribution des interactions observées aux effets toxiques de ces insecticides est peu probable car nécessitant des concentrations nettement supérieures à celles atteintes dans le cadre d’une exposition environnementale de la population générale
The general population is chronically exposed to pyrethroids and organophosphorus insecticides, mainly through alimentation. Several epidemiological studies have found an association between non-occupational exposure to these pesticides and chronic diseases and developmental disorders. Paradoxically, their biological fate in humans is poorly understood. Some studies suggest that these insecticides could interact with ABC and SLC membrane transporters. These membrane proteins, located at blood-tissue interfaces (liver, kidney, intestine ...), handle many endogenous substrates, drugs and pollutants. The objective of our study was to characterize, using an in vitro approach, the effects of pyrethroid and organophosphorus insecticides on the activity of numerous ABC and SLC human drug-transporters (P-gp, BCRP, MRPs, OATP-1B1, -2B1, -1B3, OCT1-3, OAT1, OAT3, MATE1 and MATE2K). We have also tried to analyze the mechanisms of interactions and the structural requirements for insecticides-mediated modulation of drug transporters activities using in vitro and in silico approach. We have shown that many organophosphorus and pyrethroids are able to inhibit ABC (MRP, BCRP, P-gp) and SLC (OATP1B1, OAT3, MATE1, OCT1-2) transporters and can stimulate the activity of some OATPs. Moreover, the tested pesticides inhibited very strongly the activity of OCT1 and OCT2 and blocked catecholamine transport mediated by these transporters. A qSAR approach allowed to define physicochemical parameters associated with the modulating effects of pesticides and a molecular docking approach revealed the P-gp binding sites involved in these interactions. The consequences of transporter activitie modulation, in terms of toxic effects and drug interactions, remain to be defined for populations exposed to high doses of pesticides, occurring notably in response to poisoning. However the alterations of these transporter activities by insecticides are unlikely to contribute to organophosphorus or pyrethroids toxicities of chronic low-dose exposure
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Raturi, Sagar. "Energetics and structural aspects of cation-coupled drug transport by NorM multidrug transporters." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/284914.

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NorM multidrug transport proteins belong to the multiple antibiotics and toxins extrusion (MATE) family of secondary active transporters. Members of this family are present across all species including bacteria, plants and humans. In bacteria, their over-expression can lead to antibiotic resistance, whereas in the human body, the transporters can alter the plasma levels of drugs. NorM proteins are therefore relevant for the pharmacokinetic properties of drugs. Previously, NorM from Vibrio cholerae (NorM-VC) was shown to export drug (ethidium) in an antiport reaction that is coupled to the simultaneous uptake of protons and sodium ions down their electrochemical gradients across the plasma membrane. But NorM from Pseudomonas stutzeri (NorM-PS) was shown to transport DAPI by utilising proton cycling exclusively. NorM-VC and NorM-PS share 42% identical amino-acid residues and yet their functions differ in terms of their ion coupling properties. These differences in functionality of two highly homologous proteins provide an excellent opportunity to carry out a comparative study. The work presented in this thesis investigates the energetics of drug transport processes by NorM-VC and NorM-PS and the structural basis for ion-coupled drug transport by NorM-VC. Ethidium efflux assays in intact Lactococcus lactis cells were used to study the effect of the magnitude and composition of the proton- and sodium-motive force on transport activity. Furthermore, ethidium binding assays were used to study partial reactions in drug efflux processes. These biochemical data were supplemented by computational studies and analyses of current protein structures. Based on the observations detailed here, a novel transport model for NorM-VC is proposed, which explains published findings for NorM-VC and other MATE transporters. The model represents a potentially universal mechanism for MATE transporters that can be used to predict further structure-function relationships in this important family of member transporters.
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Hoang, Thi Thanh Minh. "Caractérisation moléculaire du transport du fer dans la graine : clonage de transporteurs d'efflux d'ascorbate." Thesis, Montpellier, SupAgro, 2015. http://www.theses.fr/2015NSAM0034.

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Le fer (Fe) est un micro-élément essentiel pour les plantes. Nous avons récemment montré que l'ascorbate joue un rôle central dans le transport de Fe dans lesgrainesen participant à la réduction de Fe3+ pour l'absorption de Fe2+. En outre, l'activité de l'efflux d’ascorbate à la surface de l'embryon est cruciale dans ce processus. Nous avons utilisé une stratégie de complémentation de levure pour isoler les transporteurs d'efflux d’ascorbate, en exprimant une banqued'ADNc d'Arabidopsis dans le mutant perte de fonction de la réductase ferrique, Δfre1, incapable de se développer en carence en Fe. L’expression de deux ADNc nommésMATEet GALa permis de restaurerla croissance de Δfre1 en catalysant l’efflux de l'ascorbate dans le milieu, permettant de rétablir l'activité de réduction ferrique. Sur la base de ces résultats très prometteurs, nous avons poursuivi l’étude du rôle de ces transporteurs d'efflux d’ascorbate putatifs, MATE et GAL, dans le transport et l'homéostasie du Fe chez Arabidopsis thaliana. Dans cette étude, nous avons identifié la protéine MATE comme un transporteur vacuolaire qui est potentiellement impliqués dans le chargement d’ascorbate vers la vacuole pour réduire le Feintra-vacuolaire. Cette activité de transport est cruciale pour la remobilisation de Fe au cours de la germination et pour répondre à la carence de Fe dans le reste de la plante. La protéine GAL est localisée à la membrane plasmique où elle pourrait catalyser l’efflux d’ascorbate pour remobiliser le pool de Fe apoplastique. En effet, des mutants perte de fonction de GAL sont très sensibles à la carence en fer et perturbés dans la perception du statut nutritionnel en Fe dans des conditions de suffisance en Fe. En conclusion, les deux transporteurs d'ascorbate putatifs identifiés dans cette étude semblent être impliqués dans l'homéostasie du fer en régulant la circulation des pools de Fe subcellulaires. Cette recherche a contribué à découvrir et à mettre en évidence le lien entre le transport de fer et le métabolisme de l’ascorbate
Iron (Fe) is an essential microelement for plants. We have recently shown that ascorbate plays a central role in Fe transport to seeds by mediating Fe3+ reduction for the uptake of Fe2+. Moreover, the ascorbate efflux activity at the embryo surface was crucial in this process. We have used a yeast complementation strategy to isolate ascorbate efflux transporters, by expressing an Arabidopsis cDNA library in the Δfre1 mutant that lacks ferric reductase activity and is unable to grow in Fe limiting conditions. The expression of two cDNAs named MATE and GAL is able to rescue the growth defect of Δfre1by mediating efflux of ascorbate in the medium, reconstituting a ferric reduction activity. Therefore, we have studied the roles of putative ascorbate efflux transporters, MATE and GAL, in Fe transport and homeostasis in Arabidopsis thaliana. In this study, we have identified the MATE protein as a vacuolar transporter potentially involved in loading ascorbate to the vacuole to reduce intra-vacuolar Fe. This transport activity appears to be crucial to remobilize Fe during germination and to participate in the response to Fe deficiency in the rest of the plant, as revealed by the phenotypical analyses of knock out mutant plants. The GAL protein is localized to the plasma membrane where it could potentially catalyze the efflux of ascorbate toward the apoplast to remobilize apoplastic Fe pools. Indeed, GAL knock out mutants are highly sensitive to Fe deficiency and disturbed in the sensing of Fe nutritional status in Fe-replete conditions. In conclusion, the two putative ascorbate transporters identified in this study appear to be involved inthe iron homeostasis by regulating the movement of subcellular Fe pools. This research has contributed to discover and highlight the link between iron and ascorbate metabolism and transport
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Afonso, José Leonardo Marcelo. "Potenciais impactos socioeconômicos e ambientais na ativação de trem turístico na Zona da Mata Mineira." Universidade Federal de Juiz de Fora (UFJF), 2017. https://repositorio.ufjf.br/jspui/handle/ufjf/4667.

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Segundo o Ministério do Turismo (2013), dentre os diversos tipos de turismo existentes no Brasil, muitos estão ligados diretamente à cultura do transporte ferroviário, utilizando o trem como meio de locomoção entre localidades e, também, como herança cultural. A preservação do transporte ferroviário de passageiros ocasiona ainda em ações para a revitalização de espaços e edificações históricas pois ambas se conectam em prol do resgate da memória passada, nos fazendo observar o presente e ajudando a planejar o futuro. Considerando a hipótese da ativação de uma linha férrea em uma determinada região, devemos prever quais os possíveis impactos que serão causados para garantir um desenvolvimento regional equilibrado, guiados pelas diretrizes básicas da sustentabilidade. A proposta deste trabalho visualiza a possibilidade de se implantar um trem turístico na região da Zona da Mata Mineira, na microrregião de Juiz de Fora, compreendendo as características socioeconômicas dos munícipios envolvidos na ativação de uma possível nova linha férrea. Prevê, ainda, os potenciais impactos socioeconômicos e ambientais na região, criando uma outra hipótese do quão multimodal uma estrutura ferroviária poderá se desenvolver a longo prazo. Através de uma revisão bibliográfica voltada para o setor ferroviário no Brasil, elucida-se o panorama atual das ferrovias no país bem como os atuais trens turísticos operantes. Em um segundo momento da pesquisa, o levantamento de dados socioeconômicos dos municípios envolvidos no recorte espacial da pesquisa e de que forma a cultura ferroviária atualmente se faz presente neles, ajudam a sugerir a rota do novo trem baseada, também, em conceitos urbanísticos aplicados, para que se consiga visualizar os possíveis impactos que podem ser causados na região.
According to the Ministry of Tourism (2013), among the various types of tourism in Brazil, many are directly linked to the culture of rail transportation, using the train as a means of locomotion between localities and also as cultural heritage. The preservation of rail transport also leads to actions for the revitalization of historical spaces and buildings because both connect in favor of the rescue of past memory, making us observe the present and helping to plan the future. Considering the hypothesis of the activation of a railway line in a given region, we must predict what possible impacts will be caused to ensure a balanced regional development, guided by the basic sustainability guidelines. This work intends to visualize the possibility of establishing a tourist train in the region of Zona da Mata Mineira, in the Juiz de Fora microregion, comprising the socioeconomic characteristics of the towns involved in the activation of a possible new railway line. It also foresees the potential socioeconomic and environmental impacts in the region, creating another hypothesis of how multimodal a railway structure could develop in the long term. Through a bibliographical review focused on the railroad sector in Brazil, the current panorama of the railways in the country as well as the current operant tourist trains are elucidated. In a second moment of the research, the socioeconomic data collection of the cities involved in the spatial analysis of the research and how the railway culture is currently present in them, help to suggest the route of the new train based, also, on urbanistic concepts applied, to be able to visualize the possible impacts that can be caused in the region.
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Negreiros, Rísia Lopes. "Caracterização e análise da rede de movimento de bovinos no Estado de Mato Grosso." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/10/10134/tde-12062012-144132/.

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O objetivo deste trabalho é analisar os dados de movimentação de bovinos, gerando informações úteis à vigilância epidemiológica do Estado de Mato Grosso. Analisou-se, para 2007, a distribuição de rebanhos nas propriedades, a movimentação por ecossistema de origem e destino, por finalidade (engorda, abate ou reprodução), e por época do ano. Observou-se que 81,54% do rebanho está concentrados em 20% das propriedades, indicando a existência de poucas propriedades com intensa comercialização para abate, engorda ou reprodução e muitas propriedades com pouca comercialização. Das 72.149 propriedades (de um total de 112.924) que realizaram algum tipo de movimentação, 65.773 movimentaram bovinos. A maioria das movimentações ocorreu internamente em cada ecossistema (Pantanal, Cerrado e Amazônia). O Pantanal recebeu o menor número de bovinos (4,98% dos animais recebidos, incluindo movimentação interna) e o Cerrado foi o que mais recebeu bovinos provenientes dos outros ecossistemas e o que enviou o menor número de bovinos (318.253, 25,79% do total de bovinos enviados a outro ecossistema). Observou-se uma redução do movimento em maio e novembro (vacinação contra febre aftosa), janeiro e fevereiro (férias dos frigoríficos e estação chuvosa) e setembro (manejo de natalidade, ausência da safra do boi gordo e desmama de bezerros). O percentual de movimentação interestadual foi de 2,65% dos animais movimentados, predominando as movimentações intraestaduais. Na análise de 539.526 documentos em 76.277 estabelecimentos calculou-se o grau de comercialização entre os estabelecimentos, para o semigrau interior a média e mediana foram (1 e 3) e para o semigrau exterior(2 e 3) respectivamente. As distâncias médias para movimentação de bovinos provenientes das propriedades da fronteira internacional e daquelas sabidamente positivas para brucelose foram 73,75 e 60,43 km respectivamente. Distâncias médias para movimentos destinados a frigoríficos, propriedades e eventos agropecuários foram inferiores a 116,70 km mostrando movimentação proveniente do próprio Estado. Em redes com características livre de escala supõe-se que a distribuição de grau P(k) pode ser ajustada pela lei de potência, no entanto observou-se que alguns estabelecimentos não seguiram o previsto para redes livre de escala. O ajuste de P(kin) mostrou que estabelecimentos que compraram maior quantidade de bovinos ultrapassaram o esperado pela lei de potência, o que pode estar relacionado ao comportamento de compra por frigoríficos e confinamentos. Para o ajuste de P(kout), a proporção de propriedades que venderam para muitos estabelecimentos (por exemplo, próximo a 100 estabelecimentos) está abaixo do previsto pela lei de potência, como também aquelas que venderam para menos de 10 outros estabelecimentos. As propriedades de subsistência, que movimentam poucos animais, influenciaram os valores de P(kin) e de P(kout) para valores baixos de kin e kout, respectivamente. Observou-se uma correção negativa (r= -0,54) entre o grau médio dos primeiros vizinhos e o grau do estabelecimento mostrando que estabelecimentos com grau elevado (volume elevado de compra e/ou venda) comercializam com estabelecimentos cujo grau é em média baixo (volume baixo de compra e/ou venda) e vice-versa. Essa característica da rede de movimentação de bovinos pode ter implicações no espalhamento de doenças infecciosas nos rebanhos, em função do contato entre grandes e pequenos estabelecimentos.
This study has as objective to analyze the movement data of bovine, generating useful information for epidemiologic surveillance for Mato Grosso State. It was analyzed, for 2007, the herds distribution in the farm holdings, the movement according to origin and destination ecosystem, for purpose (fattens, slaughters or reproduction), and for year\'s time. It was observed that 81.54% of the herd was concentrated on 20% of the farm holdings, indicating the existence of few farm holdings with intense commercialization for slaughters, fattens or reproduction and many farm holdings with little commercialization. Of the 72.149 farm holdings (of a total of 112.924) that accomplished some type of movement, 65.773 moved bovine. Most movements occurred internally in each ecosystem (Pantanal, Cerrado and Amazônico). The Pantanal received the smaller number of bovine (4,98% of the received animals, including internal movement) and the Cerrado received most bovine from of the other ecosystems and sent the smaller number of bovine (318.253, 25.79% of the bovine sent to other ecosystem). It was observed a decrease in movement in May and November (vaccination against Foot and Mouth Disease), January and February (slaughterhouse vacation and rainy station) and September (birth rate handling, absence of cattle for slaughterhouse and weaning calves). The percentage of interstate movement was 2.65% of the animals moved, predominating the movements within the state This factor associated to the difficulty of maintaining updated records in complex territory motivated of the characterization of cattle network making available to the defense\'s service and epidemiological vigilance a tool that makes possible retrospective and prospectively the measures application adapted in specific situations. In the analysis of 539.526 documents in 76.277 establishments it calculated the commercialization degree between establishments. For indegree the average and median were (1 and 3) and for outdegree (2 and 3) respectively. Average distances for bovine movement with origin in the farms holdings of the international border and the farms holdings known positive for brucellosis were 73.75 and 60.43 km respectively. Average distances from farm holdings to slaughter establishments, farms holdings and agricultural events were lower than 116.70 km showing movement originating within the state. In scale-free networks, the degree distribution P(k) it can be fitted by the power law, however some establishments do not follow the foreseen for networks free-scale. The fitting of P(kin) showed that establishments that buy larger quantity of bovine overtake what is expected for power law, what can be related to purchase behavior for slaughter establishments and confinements. For the fitting of P(kout), the proportion of the farms holdings that sell for lots of establishments (for example, near to 100 establishments) is below the expected by the power law, as well as those that sell for less than 10 other establishments. The subsistence farms holdings, that move few animals, influence the values of P(kin) and of P(kout) for low values of kin and kout, respectively. A negative correlation (r= -0.54) was observed between the average degree of nearest neighbors and the degree of establishments, showing that establishments with high degree of purchase and/or sells, commercialize with establishments whose degree is, on average, low (low quantity of purchase and/or sells) and vice versa. This characteristic of the network of bovine movement may have implications in the spread of infectious diseases within the herds, depending on the contact between big and small establishments.
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Alasmari, Fawaz Fayez. "Effects of Beta-Lactam Antibiotics on Cystine /Glutamate Exchanger Transporter and Glutamate Transporter 1 Isoforms as well as Ethanol Drinking Behavior in Male P Rats." University of Toledo Health Science Campus / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=mco1435826676.

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Oliveira, Nilton Marques de. "Transporte e localização da agroindústria da soja no estado de Mato Grosso." Universidade Federal de Viçosa, 2003. http://www.locus.ufv.br/handle/123456789/8999.

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O objetivo geral deste trabalho foi identificar e analisar as rodovias na alocação modal ótima que minimizem os custos de transportes entre as áreas de produção à agroindústria e determinar a localização ótima de novas agroindústrias no Estado de Mato Grosso. O modelo teórico proposto foi baseado a partir da teoria de localização da produção agrícola de Von THÜNEN e da teoria de localização de atividades industriais desenvolvida por WEBER. Utilizou-se como instrumento analítico um modelo de redes capacitadas. A partir de uma solução padrão, simulou-se vários cenários na melhoria da infra-estrutura de transporte da malha rodoviária e na implementação da rede ferroviária. O modelo de localização de atividades agroindustriais envolveu uma estrutura de programação inteira. As variáveis consideradas para o objetivo do estudo foram os custos de transportes de grãos (soja) até a agroindústria; quantidade de produção de soja e o custo de instalação e ampliação de novas agroindústrias. Os principais resultados mostram que a pavimentação das principais rodovias estaduais no Estado produziria efeitos em termos de redução do custo total de distribuição de soja, em relação à solução padrão. Com a simulação da ferrovia, o efeito seria maior. O modelo selecionou para a instalação de novas agroindústrias os Pólos de Alto Taquari e Tangará da Serra. Tal resultado pode ser justificado pelo fato de os Pólos se concentrarem próximos aos centros produtores de soja e de fácil escoamento para outros estados.
The main objective of this work is to identify and analyze highways in the most efficient location, in order to minimize the transportation cost from the production area to the agroindustry, and to determine the most efficient location for new agroindustries in Mato Grosso, Brazil. The theorical model proposed was based on the agricultural production localization theory, by von Thünen, and on the industrial activities localization theory, by Weber. One model of net work was utilized as analytical instrument. From the analysis of the current situation, several sceneries were simulated for infra-structure improvement of highway transport and for railway implement. The agroindustrial activities localization model involved an entire programation structure. The variables considered for the study objective were the costs of grain (soybean) transport to the agroindustry; soybean production amount, and the installation and amplification cost for new agroindustries. The main results show that the principal state highways pavement would decrease the total cost of soybean distribution, in comparison with the current situation. With railway simulation, the effect would be bigger. The model selected, for new agroindustries installation, are the Poles of Alto Taquari and Tangará da Serra. Such a result can be justified by the fact that the Poles are concentrated near centers which are soybean productors and have easy outflow for other states.
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Books on the topic "MATE transporter"

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Bibicescu, Gheorghe. Transportul de mărfuri pe mare în comerțul internațional: Aspecte juridice și tehnico-economice. București: Editura Sport-Turism, 1986.

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Luepke, Gretchen. Variations in titanium and chromium concentrations in magnetite separates from beach and offshore sediments, San Francisco and San Mateo counties, California. Menlo Park, Calif: U.S. Dept. of the Interior, U.S. Geological Survey, 1994.

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Luepke, Gretchen. Variations in titanium and chromium concentrations in magnetite separates from beach and offshore sediments, San Francisco and San Mateo counties, California. Menlo Park, Calif: U.S. Dept. of the Interior, U.S. Geological Survey, 1994.

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Luepke, Gretchen. Variations in titanium and chromium concentrations in magnetite separates from beach and offshore sediments, San Francisco and San Mateo counties, California. Menlo Park, Calif: U.S. Dept. of the Interior, U.S. Geological Survey, 1994.

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Cevelev, Aleksandr. The economy and material management on a railway transport. ru: INFRA-M Academic Publishing LLC., 2020. http://dx.doi.org/10.12737/1085329.

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In the textbook in an accessible form presented and discussed the development of the economy and the inventory management of railway transport in the new economic environment. For the first time in Russian literature, made a theoretical attempt at a comprehensive review of the effectiveness of, and satisfaction of needs in material resources structural divisions, subsidiaries and affiliates of JSC "RZD". According to the results of theoretical research, innovative and production potential of the supply system of railway transport the main directions and methods of transformation of the restructuring process under the corporate changes of JSC "RZD", positioned value system of logistics of rail transport, a comprehensive approach to the development of systems of balanced indicators of supply and prompt handling of material resources. Recommendations for the implementation of the developed algorithms and models are long term in nature and are based on the concept of logistics management improve business processes, system logistics. For students and teachers, workers of enterprises of railway transport, and others interested in questions of transport Economics.
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Brown, A. M. Ionic mechanisms of aglycemic axon injury in mammalian central white mater. Philadelphia, Penn: Lippincott Williams & Wilkins, Inc., 2001.

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Brown, A. M. Metabolic substrates other than glucose support axon function in central white mater. New York, N.Y: Wiley-Liss, Inc., 2001.

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Vallejo Maldonado, Pablo Ramon, and Nikolay Chaynov. Kinematics and dynamics of automobile piston engines. ru: INFRA-M Academic Publishing LLC., 2019. http://dx.doi.org/10.12737/989072.

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The fundamentals of kinematics and dynamics of transport piston internal combustion engines made using different layout schemes are presented. Along with the traditional in-line, V-shaped, including oppositional, arrangement of cylinders, schemes with "staggered" arrangement of cylinders in the block at the displaced connecting rod necks of the crankshaft of the engine are considered. The kinematics of the coaxial crank mechanism is considered in detail. The questions of dynamics with reduction of calculated dependences of forces, moments, a choice of a rational order of work of cylinders in relation to the considered kinematic schemes are in detail stated. Considerable attention is paid to the unevenness of the crankshaft rotation speed and engine balancing. The loads on the main and connecting rod bearings of the crankshaft, the knowledge of which is necessary in determining the bearing capacity of bearing units, are also considered. Meets the requirements of the Federal state educational standards of higher education of the last generation. For students of higher educational institutions studying in the direction of training 23.03.03 "Operation of transport and technological machines and complexes" and related areas.
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The sinking of the Lancastria: The twentieth century's deadliest naval disaster and how Ch[u]rchill made it disappear. New York: Carroll & Graf, 2005.

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Office, Great Britain Colonial. Emigration: Copies of reports made to the governors and councils of Canada, New Brunswick, and New South Wales. [London: HMSO, 2001.

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Book chapters on the topic "MATE transporter"

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Yonezawa, Atsushi, and Ken-ichi Inui. "MATE (SLC47) Family." In Pharmacogenomics of Human Drug Transporters, 209–22. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2013. http://dx.doi.org/10.1002/9781118353240.ch9.

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Abeyratne, Ruwantissa. "How to Make Rules." In Rulemaking in Air Transport, 97–118. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-44657-8_3.

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Smart, Nigel P. "Certificates, Key Transport and Key Agreement." In Cryptography Made Simple, 369–99. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-21936-3_18.

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Abeyratne, Ruwantissa. "How Not to Make Rules." In Rulemaking in Air Transport, 1–80. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-44657-8_1.

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Motohashi, Hideyuki, and Ken-ichi Inui. "Pharmacological and Toxicological Significance of the Organic Cation Transporters OCT and MATE: Drug Disposition, Interaction and Toxicity." In Organic Cation Transporters, 73–92. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-23793-0_3.

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Ellis, L. C., and B. R. Nemetallah. "Sperm maturation and transport." In Male Fertility and Its Regulation, 397–409. Dordrecht: Springer Netherlands, 1985. http://dx.doi.org/10.1007/978-94-009-4894-5_27.

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Fleischer, Bernhard, and Hans Theumert. "Konstruktion einer Transport- und Handhabungsvorrichtung." In Roloff/Matek: Entwickeln Konstruieren Berechnen, 207–43. Wiesbaden: Springer Fachmedien Wiesbaden, 2018. http://dx.doi.org/10.1007/978-3-658-22747-0_8.

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Fleischer, Bernhard, and Hans Theumert. "Konstruktion einer Transport- und Handhabungsvorrichtung." In Roloff/Matek: Entwickeln Konstruieren Berechnen, 209–45. Wiesbaden: Springer Fachmedien Wiesbaden, 2020. http://dx.doi.org/10.1007/978-3-658-31173-5_8.

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Abeyratne, Ruwantissa. "Can ICAO Make Laws or Deliver Judgments?" In Rulemaking in Air Transport, 81–96. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-44657-8_2.

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Filipowicz, Włodzimierz. "Compass Made Good Correction with MTE." In Telematics in the Transport Environment, 69–78. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-34050-5_9.

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Conference papers on the topic "MATE transporter"

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Radulescu, V., I. Strainescu, L. C. Moroianu, V. Serbu, E. Tudor, S. Gheorghe, C. Goia, et al. "Driving equipments made by ICPE SAERP for urban electric transport vehicles." In URBAN TRANSPORT 2008. Southampton, UK: WIT Press, 2008. http://dx.doi.org/10.2495/ut080201.

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Fuć, P. "Nanotechnology and modern materials as a way to make road transportation cleaner." In URBAN TRANSPORT 2008. Southampton, UK: WIT Press, 2008. http://dx.doi.org/10.2495/ut080341.

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Merkisz, J., M. Bajerlein, and W. Kozak. "Dissolving oxygen in diesel fuel as a way to make road transport more environmentally friendly." In URBAN TRANSPORT 2008. Southampton, UK: WIT Press, 2008. http://dx.doi.org/10.2495/ut080321.

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Keong, Ang Poh, K. G. Smitha, and Sharad Sinha. "Smart Nation: Offline Public Transport Made Easy." In 2019 4th International Conference on Intelligent Transportation Engineering (ICITE). IEEE, 2019. http://dx.doi.org/10.1109/icite.2019.8880262.

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Shiraishi, Masashi. "Electron Transport in Single-Wall Carbon Nanotube Mats." In STRUCTURAL AND ELECTRONIC PROPERTIES OF MOLECULAR NANOSTRUCTURES: XVI International Winterschool on Electronic Properties of Novel Materials. AIP, 2002. http://dx.doi.org/10.1063/1.1514116.

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Borchardt, Ralf. "Transport of the Reactor Pressure Vessels in the Greifswald Nuclear Power Plant." In ASME 2009 12th International Conference on Environmental Remediation and Radioactive Waste Management. ASMEDC, 2009. http://dx.doi.org/10.1115/icem2009-16012.

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Five WWER-440 reactors are being dismantled on the Greifswald Nuclear Power Plant (KGR) site. The strategy for the dismantling of the reactor units 1 to 4 (operation time 12–17 years) was to cut and pack the components remotely. For this purpose dry and wet cutting areas were installed. The remote cutting and packing of the reactor pressure vessel and its internals was successfully tested with non-activated original reactor components of units 7 and 8 from October 1999 until July 2003. From August 2004 until July 2007 the internals from reactor units 1 and 2 were cut, packed and transported to the on-site Interim Store North (ISN). For the reactor 5 it was planned to transport the RPV in one piece and the reactor internals in shielding and transport containers to the interim store for decay storage. In December 2003 the RPV of unit 5 was lifted and transported to the interim store. From April 2006 up to July 2006 the reactor internals of unit 5 were packed and transported to the interim store. After the evaluation of the experience made during the transport and the radiological measurements and samplings taken from the RPV unit 1, the strategy for the dismantling of the reactors was changed. The reactor pressure vessels of the units 1 to 4 and the reactor internals of the units 3 and 4 should be removed as complete parts and stored as shielded large components in the ISN. In summer 2005 EWN applied for the new strategy at the responsible licensing authority and in August 2007 this license was granted. In November 2007 the reactor pressure vessels of the units 1 and 2 were transported into the ISN. The transport of the reactor pressure vessels and the internals from units 3 and 4 is planned in the period from March till September 2009. These transports of the reactor pressure vessels and internals show that the dismantling of the reactors with dismantling and interim storage of large components could not only be an alternative for cutting but could also be favored from the economical and radiological point of view.
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Eyrikh, Nadezhda V., Boris E. Fishman, Ruslan I. Bazhenov, Natalia V. Markova, and Inessa L. Pitsuk. "Hands-On Games for Motivating Students' Math Training." In 2019 International Conference "Quality Management, Transport and Information Security, Information Technologies" (IT&QM&IS). IEEE, 2019. http://dx.doi.org/10.1109/itqmis.2019.8928404.

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Drapalyuk, Mihail V., Vladimir A. Zelikov, Valerii I. Posmetev, Vadim O. Nikonov, and Eugene V. Shatalov. "Simulation Results to Assess Effectiveness of Seals Made of Polyurethane for Hydraulic Drives of Machines." In International Conference "Aviamechanical engineering and transport" (AVENT 2018). Paris, France: Atlantis Press, 2018. http://dx.doi.org/10.2991/avent-18.2018.89.

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Kudryashov, Evgeniy Alekseevich, Igor Mikhailovich Smirnov, and Nikolay Andreevich Khizhnyak. "Selection and evaluation of the efficiency of cutting inserts made of various cutting tool materials." In International Conference "Aviamechanical engineering and transport" (AVENT 2018). Paris, France: Atlantis Press, 2018. http://dx.doi.org/10.2991/avent-18.2018.43.

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Guimaraes, Kelton, and Jean-David Caprace. "Composição de custos de frete multimodais no Brasil – um estudo de caso da exportação da produção agrícola do Mato Grosso." In 11° SEMINÁRIO INTERNACIONAL DE TRANSPORTE E DESENVOLVIMENTO HIDROVIÁRIO INTERIOR. Galoa, 2019. http://dx.doi.org/10.17648/sobena-hidroviario-2019-110532.

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Reports on the topic "MATE transporter"

1

Götz, Konrad, Ueli Haefeli, and Daniel Meierhans. Thematic synthesis “Mobility Behaviour” of the NRP “Energy”. Swiss National Science Foundation (SNSF), September 2019. http://dx.doi.org/10.46446/publication_nrp70_nrp71.2019.5.en.

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How can the high share of Swiss energy consumption accounted for by transport be reduced to the extent required for the transformation of the energy system? On the basis of the mobility-related results of the NRP Energy, this synthesis identifies the key challenges, bringing them together to make recommendations for action.
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2

Beck, Aaron. RiverOceanPlastic: Land-ocean transfer of plastic debris in the North Atlantic, Cruise No. AL534/2, 05 March – 26 March 2020, Malaga (Spain) – Kiel (Germany). GEOMAR Helmholtz Centre for Ocean Research Kiel, 2020. http://dx.doi.org/10.3289/cr_al534-2.

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Cruise AL534/2 is part of a multi-disciplinary research initiative as part of the JPI Oceans project HOTMIC and sought to investigate the origin, transport and fate of plastic debris from estuaries to the oceanic garbage patches. The main focus of the cruise was on the horizontal transfer of plastic debris from major European rivers into shelf regions and on the processes that mediate this transport. Stations were originally chosen to target the outflows of major European rivers along the western Europe coast between Malaga (Spain) and Kiel (Germany), although some modifications were made in response to inclement weather. In total, 16 stations were sampled along the cruise track. The sampling scheme was similar for most stations, and included: 1) a CTD cast to collect water column salinity and temperature profiles, and discrete samples between surface and seafloor, 2) sediment sampling with Van Veen grab and mini-multi corer (mini-MUC), 3) suspended particle and plankton sampling using a towed Bongo net and vertical WP3 net, and 4) surface neusten sampling using a catamaran trawl. At a subset of stations with deep water, suspended particles were collected using in situ pumps deployed on a cable. During transit between stations, surface water samples were collected from the ship’s underway seawater supply, and during calm weather, floating litter was counted by visual survey teams. The samples and data collected on cruise AL534/2 will be used to determine the: (1) abundance of plastic debris in surface waters, as well as the composition of polymer types, originating in major European estuaries and transported through coastal waters, (2) abundance and composition of microplastics (MP) in the water column at different depths from the sea surface to the seafloor including the sediment, (3) abundance and composition of plastic debris in pelagic and benthic organisms (invertebrates), (4) abundance and identity of biofoulers (bacteria, protozoans and metazoans) on the surface of plastic debris from different water depths, (5) identification of chemical compounds (“additives”) in the plastic debris and in water samples.
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Pokrzywinski, Kaytee, Kaitlin Volk, Taylor Rycroft, Susie Wood, Tim Davis, and Jim Lazorchak. Aligning research and monitoring priorities for benthic cyanobacteria and cyanotoxins : a workshop summary. Engineer Research and Development Center (U.S.), August 2021. http://dx.doi.org/10.21079/11681/41680.

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In 2018, the US Army Engineer Research and Development Center partnered with the US Army Corps of Engineers–Buffalo District, the US Environmental Protection Agency, Bowling Green State University, and the Cawthron Institute to host a workshop focused on benthic and sediment-associated cyanobacteria and cyanotoxins, particularly in the context of harmful algal blooms (HAB). Technical sessions on the ecology of benthic cyanobacteria in lakes and rivers; monitoring of cyanobacteria and cyanotoxins; detection of benthic and sediment-bound cyanotoxins; and the fate, transport, and health risks of cyanobacteria and their associated toxins were presented. Research summaries included the buoyancy and dispersal of benthic freshwater cyanobacteria mats, the fate and quantification of cyanotoxins in lake sediments, and spatial and temporal variation of toxins in streams. In addition, summaries of remote sensing methods, omic techniques, and field sampling techniques were presented. Critical research gaps identified from this workshop include (1) ecology of benthic cyanobacteria, (2) identity, fate, transport, and risk of cyanotoxins produced by benthic cyanobacteria, (3) standardized sampling and analysis protocols, and (4) increased technical cooperation between government, academia, industry, nonprofit organizations, and other stakeholders. Conclusions from this workshop can inform monitoring and management efforts for benthic cyanobacteria and their associated toxins.
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4

McAlpin, Jennifer N., and Cassandra G. Ross. Houston Ship Channel Expansion Channel Improvement Project (ECIP) Numerical Modeling Report : Increased Channel Width Analysis. Engineer Research and Development Center (U.S.), February 2021. http://dx.doi.org/10.21079/11681/39739.

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The Houston Ship Channel is one of the busiest deep -draft navigation channels in the United States and must be able to accommodate larger vessel dimensions over time. The U.S. Army Engineer District, Galveston (SWG) requested the U.S. Army Engineer Research and Development Center, Coastal and Hydraulics Laboratory perform hydrodynamic and sediment modeling of proposed modifications along the Houston Ship Channel. The modeling results are necessary to provide data for salinity and sediment transport analysis a s well as ship simulation studies. SWG provided a project alternative that includes channel widening, deepening, and bend easing. After initial analysis, two additional channel widths in the bay portion of the Houston Ship Channel were requested for testing. The results of these additional channel widths are presented in this report. The model shows that the salinity does not vary significantly due to the channel modifications being considered for this project. Changes in salinity are 2 parts per thousand or less. The tidal prism increases by less than 2% when the project is included, and the tidal amplitudes increase by no more than 0.01 meter. The residual velocity vectors do vary in and around areas where project modifications are made.
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McAlpin, Jennifer, and Cassandra Ross. Houston Ship Channel Expansion Channel Improvement Project (ECIP) numerical modeling report : BABUS cell and Bird Island analysis. Engineer Research and Development Center (U.S.), August 2021. http://dx.doi.org/10.21079/11681/41581.

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The Houston Ship Channel (HSC) is one of the busiest deep-draft navigation channels in the United States and must be able to accommodate increasing vessel sizes. The US Army Engineer District, Galveston (SWG), requested the Engineer Research and Development Center, Coastal and Hydraulics Laboratory, perform hydrodynamic and sediment modeling of proposed modifications in Galveston and Trinity Bays and along the HSC. The modeling results are necessary to provide data for hydrodynamic, salinity, and sediment transport analysis. SWG provided three project alternatives that include closing Rollover Pass, Bay Aquatic Beneficial Use System cells, Bird Islands, and HSC modifications. These alternatives and a Base (existing condition) will be simulated for present (2029) and future (2079) conditions. The results of these alternatives/conditions as compared to the Base are presented in this report. The model shows that the mean salinity varies by 2–3 ppt due to the HSC channel modifications and by approximately 5 ppt in the area of East Bay due to the closure of Rollover Pass. The tidal prism increases by 2.5% to 5% in the alternatives. The tidal amplitudes change by less than 0.01 m. The residual velocity vectors vary in and around areas where project modifications are made.
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6

Fowler, Joanna, and Michael Furey. An open-label, randomized positron emission tomography (PET)study in healthy male volunteers consisiting of Part A and Part B.Part A: Clinical validation of norepinephrine transporter (NET) PET ligand, (S,S)-[11C]O-methylreboxetine ([11C]MRB) using different doses of oral atomoxetine as NET reuptake inhibitor.Part B: Evaluation of NET occupancy, as measured by [11C]MRB, with multiple dosing regimens of orally administered GSK372475. Office of Scientific and Technical Information (OSTI), August 2007. http://dx.doi.org/10.2172/973576.

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7

Petrie, John, Yan Qi, Mark Cornwell, Md Al Adib Sarker, Pranesh Biswas, Sen Du, and Xianming Shi. Design of Living Barriers to Reduce the Impacts of Snowdrifts on Illinois Freeways. Illinois Center for Transportation, November 2020. http://dx.doi.org/10.36501/0197-9191/20-019.

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Blowing snow accounts for a large part of Illinois Department of Transportation’s total winter maintenance expenditures. This project aims to develop recommendations on the design and placement of living snow fences (LSFs) to minimize snowdrift on Illinois highways. The research team examined historical IDOT data for resource expenditures, conducted a literature review and survey of northern agencies, developed and validated a numerical model, field tested selected LSFs, and used a model to assist LSF design. Field testing revealed that the proper snow fence setback distance should consider the local prevailing winter weather conditions, and snow fences within the right-of-way could still be beneficial to agencies. A series of numerical simulations of flow around porous fences were performed using Flow-3D, a computational fluid dynamics software. The results of the simulations of the validated model were employed to develop design guidelines for siting LSFs on flat terrain and for those with mild slopes (< 15° from horizontal). Guidance is provided for determining fence setback, wind characteristics, fence orientation, as well as fence height and porosity. Fences comprised of multiple rows are also addressed. For sites with embankments with steeper slopes, guidelines are provided that include a fence at the base and one or more fence on the embankment. The design procedure can use the available right-of-way at a site to determine the appropriate fence characteristics (e.g., height and porosity) to prevent snow deposition on the road. The procedure developed in this work provides an alternative that uses available setback to design the fence. This approach does not consider snow transport over an entire season and may be less effective in years with several large snowfall events, very large single events, or a sequence of small events with little snowmelt in between. However, this procedure is expected to be effective for more frequent snowfall events such as those that occurred over the field-monitoring period. Recommendations were made to facilitate the implementation of research results by IDOT. The recommendations include a proposed process flow for establishing LSFs for Illinois highways, LSF siting and design guidelines (along with a list of suitable plant species for LSFs), as well as other implementation considerations and identified research needs.
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8

Atkinson, Dan, and Alex Hale, eds. From Source to Sea: ScARF Marine and Maritime Panel Report. Society of Antiquaries of Scotland, September 2012. http://dx.doi.org/10.9750/scarf.09.2012.126.

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The main recommendations of the panel report can be summarised under four headings: 1. From Source to Sea: River systems, from their source to the sea and beyond, should form the focus for research projects, allowing the integration of all archaeological work carried out along their course. Future research should take a holistic view of the marine and maritime historic environment, from inland lakes that feed freshwater river routes, to tidal estuaries and out to the open sea. This view of the landscape/seascape encompasses a very broad range of archaeology and enables connections to be made without the restrictions of geographical or political boundaries. Research strategies, programmes From Source to Sea: ScARF Marine and Maritime Panel Report iii and projects can adopt this approach at multiple levels; from national to site-specific, with the aim of remaining holistic and cross-cutting. 2. Submerged Landscapes: The rising research profile of submerged landscapes has recently been embodied into a European Cooperation in Science and Technology (COST) Action; Submerged Prehistoric Archaeology and Landscapes of the Continental Shelf (SPLASHCOS), with exciting proposals for future research. Future work needs to be integrated with wider initiatives such as this on an international scale. Recent projects have begun to demonstrate the research potential for submerged landscapes in and beyond Scotland, as well as the need to collaborate with industrial partners, in order that commercially-created datasets can be accessed and used. More data is required in order to fully model the changing coastline around Scotland and develop predictive models of site survival. Such work is crucial to understanding life in early prehistoric Scotland, and how the earliest communities responded to a changing environment. 3. Marine & Maritime Historic Landscapes: Scotland’s coastal and intertidal zones and maritime hinterland encompass in-shore islands, trans-continental shipping lanes, ports and harbours, and transport infrastructure to intertidal fish-traps, and define understanding and conceptualisation of the liminal zone between the land and the sea. Due to the pervasive nature of the Marine and Maritime historic landscape, a holistic approach should be taken that incorporates evidence from a variety of sources including commercial and research archaeology, local and national societies, off-shore and onshore commercial development; and including studies derived from, but not limited to history, ethnology, cultural studies, folklore and architecture and involving a wide range of recording techniques ranging from photography, laser imaging, and sonar survey through to more orthodox drawn survey and excavation. 4. Collaboration: As is implicit in all the above, multi-disciplinary, collaborative, and cross-sector approaches are essential in order to ensure the capacity to meet the research challenges of the marine and maritime historic environment. There is a need for collaboration across the heritage sector and beyond, into specific areas of industry, science and the arts. Methods of communication amongst the constituent research individuals, institutions and networks should be developed, and dissemination of research results promoted. The formation of research communities, especially virtual centres of excellence, should be encouraged in order to build capacity.
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National report 2009-2019 - Rural NEET in Hungary. OST Action CA 18213: Rural NEET Youth Network: Modeling the risks underlying rural NEETs social exclusion, December 2020. http://dx.doi.org/10.15847/cisrnyn.nrhu.2020.12.

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In Hungary, NEET Youth are faced with many problems: social exclusion; lack of opportunities (e.g., education, health, infrastructure, public transport, labour market conditions); low so-cio-economic status; and, a lack of relationships outside the enclosed settlements. In Hungary, the most frequent risk factors are: a socio-economically disadvantageous envi-ronment; low levels of education and schooling problems; lack of proper housing; financial problems; learning difficulties; dissatisfaction with the school; socio-emotional disorders; delinquency; health problems; homelessness; and, drug or alcohol abuse. NEET Youth are fa-cing with this multi-dimensional difficulties, regional disparities and a lack of proper services.The general employment statistics have been improving in Hungary since 2010. The emplo-yment rate of the 15-39-year-old population has increased from 53.0% to 62.5% between 2009 - 2019. The employment rate improved in every type of settlement/area. The improve-ment can be attributed to the community work in the marginalised regions micro-regions and settlements. The NEET rate shows a considerable improvement of nearly 40% between 2009 and 2019 in the urban environment for all age groups. A slight improvement can be detected in the towns and urban environment, which amounts to 25% for all age groups between 2009 and 2019. However special services and targeted programmes are required to make a diffe-rence for NEET Youth.
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