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Journal articles on the topic 'Mass Spectrometry technique'

Author: Grafiati

Published: 9 March 2023

Last updated: 10 March 2023

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1

R Swetha Sri, B Aishwarya, D Vaishnavi, and M Sumakanth. "A review on ion mobility mass spectrometry." Open Access Research Journal of Biology and Pharmacy 6, no. 2 (November 30, 2022): 013–23. http://dx.doi.org/10.53022/oarjbp.2022.6.2.0067.

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Mass Spectrometry can be coupled with ion mobility to get results that cannot be obtained by alone mass spectrometry. This coupled instrument can be used for knowing the separation of isomers, isobars, and conformers, the reduction of chemical noise, and the measurement of ion size. It divides ions into families of ions as well as ions with the same charge and similar structural properties. The four ion mobility separation techniques currently applied to mass spectrometry are described in this article. Low-resolution mobility separation is demonstrated by AIMS. Offering continuous ion monitorings are DMS and FAIMS. TWIMS is a novel IMS technique that has good sensitivity and is well integrated into a commercial mass spectrometer while having modest resolving power. In this review it includes that Many researches has used this technique has it gives results in millisecond and its low cost operation.it has major drawback of contamination of compounds due to atmospheric pressure, complex spectra and interferences aredue to wide spread of ionization.it is not suitable for Non-volatile compound and the repoducubility is1-2%.

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2

Niwa, Toshimitsu, and Akira Shimizu. "New challenge of mass spectrometry technique." Journal of Chromatography B 855, no. 1 (August 2007): 1. http://dx.doi.org/10.1016/j.jchromb.2007.02.051.

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Chan, Daniel Shiu-Hin, Andrew J. Whitehouse, Anthony G. Coyne, and Chris Abell. "Mass spectrometry for fragment screening." Essays in Biochemistry 61, no. 5 (October 6, 2017): 465–73. http://dx.doi.org/10.1042/ebc20170071.

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Fragment-based approaches in chemical biology and drug discovery have been widely adopted worldwide in both academia and industry. Fragment hits tend to interact weakly with their targets, necessitating the use of sensitive biophysical techniques to detect their binding. Common fragment screening techniques include differential scanning fluorimetry (DSF) and ligand-observed NMR. Validation and characterization of hits is usually performed using a combination of protein-observed NMR, isothermal titration calorimetry (ITC) and X-ray crystallography. In this context, MS is a relatively underutilized technique in fragment screening for drug discovery. MS-based techniques have the advantage of high sensitivity, low sample consumption and being label-free. This review highlights recent examples of the emerging use of MS-based techniques in fragment screening.

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Szpunar, J., and R. Lobinski. "Species-selective Analysis for Metal - Biomacromolecular Complexes using Hyphenated Techniques." Pure and Applied Chemistry 71, no. 5 (May 30, 1999): 899–918. http://dx.doi.org/10.1351/pac199971050899.

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Analytical chemistry of metal complexes with biomacromolecules based on the coupling of a high resolution separation technique with an element or species selective detection technique is critically discussed. The role of size-exclusion chromatography (SEC) with on-line atomic spectrometric detection is evaluated for the characterization of the metal distribution among the fractions of different molecular weight. Attention is given to the conditions for the separation of metallated biomacromolecular isoforms and sub-isoforms by anion-exchange and reversed-phase HPLC. Techniques for interfacing chromatography with atomic absorption spectrometry (AAS), inductively coupled plasma atomic emission spectrometry (ICP AES) and ICP mass spectrometry (ICP MS) are assessed. The potential of electrospray (tandem) mass spectrometry for the on-line determination of the molecular mass of the eluting protein is highlighted. Perspectives for capillary zone electrophoresis (CZE), microbore and capillary HPLC with ICP MS and electrospray MS detection for probing metalloproteins are discussed. Applications of hyphenated techniques to the analysis of real-world samples are reviewed.

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Davies, S., J. A. Rees, and D. L. Seymour. "Threshold ionisation mass spectrometry (TIMS); a complementary quantitative technique to conventional mass resolved mass spectrometry." Vacuum 101 (March 2014): 416–22. http://dx.doi.org/10.1016/j.vacuum.2013.06.004.

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6

Termopoli, Veronica, Maurizio Piergiovanni, Davide Ballabio, Viviana Consonni, Emmanuel Cruz Muñoz, and Fabio Gosetti. "Condensed Phase Membrane Introduction Mass Spectrometry: A Direct Alternative to Fully Exploit the Mass Spectrometry Potential in Environmental Sample Analysis." Separations 10, no. 2 (February 17, 2023): 139. http://dx.doi.org/10.3390/separations10020139.

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Membrane introduction mass spectrometry (MIMS) is a direct mass spectrometry technique used to monitor online chemical systems or quickly quantify trace levels of different groups of compounds in complex matrices without extensive sample preparation steps and chromatographic separation. MIMS utilizes a thin, semi-permeable, and selective membrane that directly connects the sample and the mass spectrometer. The analytes in the sample are pre-concentrated by the membrane depending on their physicochemical properties and directly transferred, using different acceptor phases (gas, liquid or vacuum) to the mass spectrometer. Condensed phase (CP) MIMS use a liquid as a medium, extending the range to new applications to less-volatile compounds that are challenging or unsuitable to gas-phase MIMS. It directly allows the rapid quantification of selected compounds in complex matrices, the online monitoring of chemical reactions (in real-time), as well as in situ measurements. CP-MIMS has expanded beyond the measurement of several organic compounds because of the use of different types of liquid acceptor phases, geometries, dimensions, and mass spectrometers. This review surveys advancements of CP-MIMS and its applications to several molecules and matrices over the past 15 years.

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Vidová, Veronika, Michael Volný, Karel Lemr, and Vladimír Havlíček. "Surface analysis by imaging mass spectrometry." Collection of Czechoslovak Chemical Communications 74, no. 7-8 (2009): 1101–16. http://dx.doi.org/10.1135/cccc2009028.

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A review of four MS-based techniques available for molecular surface imaging is presented. The main focus is on the commercially available mass spectrometry imaging techniques: secondary ion mass spectrometry (SIMS), matrix assisted laser desorption ionization mass spectrometry (MALDI-MS), desorption electrospray ionization mass spectrometry (DESI-MS) and laser ablation inductively-coupled plasma mass spectrometry (LA-ICP-MS). A short historical perspective is presented and traditional desorption ionization techniques are also briefly described. The four techniques are compared mainly with respect to their usage for imaging of biological surfaces. MALDI is evaluated as the most successful in life sciences and the only technique usable for imaging of large biopolymers. SIMS is less common but offers superior spatial lateral resolution and DESI is considered to be an emerging alternative approach in mass spectrometry imaging. LA-ICP ionization is unbeatable in terms of limits of detection but does not provide structural information. All techniques are considered extremely useful, representing a new wave of expansion of mass spectrometry into surface science and bioanalysis. A minireview with 121 references.

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8

Woehlck, Harvey J., Marshall Dunning, Kasem Nithipatikom, Alexander H. Kulier, and Daniel W. Henry. "Mass Spectrometry Provides Warning of Carbon Monoxide Exposure Via Trifluoromethane." Anesthesiology 84, no. 6 (June 1, 1996): 1489–93. http://dx.doi.org/10.1097/00000542-199606000-00026.

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Background The chemical breakdown of isoflurane, enflurane, or desflurane in dried carbon dioxide absorbents may produce carbon monoxide. Some mass spectrometers can give false indications of enflurane during anesthetic breakdown. Methods During clinical anesthesia with isoflurane or desflurane, the presence of carbon monoxide in respiratory gas was confirmed when enflurane was inappropriately indicated by a clinical mass spectrometer that identified enflurane at mass to charge ratio = 69. In vitro, isoflurane, enflurane, or desflurane in oxygen was passed through dried carbon dioxide absorbents at 35, 45, and 55 degrees C. Gases were analyzed by gas chromatography and by mass spectrometry. Results Mass spectrometry identified several clinical incidents in which 30-410 ppm carbon monoxide was measured in respiratory gas. Trifluoromethane was produced during in vitro breakdown of isoflurane or desflurane. Although these inappropriately indicated quantities of "enflurane" correlated (r2 > 0.95) to carbon monoxide concentrations under a variety of conditions, this ratio varied with temperature, anesthetic agent, absorbent type, and water content. Conclusions Trifluoromethane causes the inappropriate indication of enflurane by mass spectrometry, and indicates isoflurane and desflurane breakdown. Because the ratio of carbon monoxide to trifluoromethane varies with conditions, this technique cannot be used to quantitatively determine the amount of carbon monoxide to which a patient is exposed. If any warning of anesthetic breakdown results from this technique then remedial steps should be taken immediately to stop patient exposure to carbon monoxide. No warning can be provided for the breakdown of enflurane by this technique.

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Bhole, R. P., S. R. Jagtap, K. B. Chadar, and Y. B. Zambare. "Liquid Chromatography-Mass Spectrometry Technique-A Review." Research Journal of Pharmacy and Technology 13, no. 1 (2020): 505. http://dx.doi.org/10.5958/0974-360x.2020.00097.9.

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Satoh, Takaya, Kentaro Takahara, Tomoaki Kondo, Ryo Ogasawara, and Chika Nogami. "Recent data analysis technique in mass spectrometry." Japanese Journal of Pesticide Science 42, no. 1 (2017): 203–15. http://dx.doi.org/10.1584/jpestics.w17-54.

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Jiang, Songsheng, Shan Jiang, Chunsheng Li, Ming He, Shaoyong Wu, and Silin Li. "Determination of79Se with accelerator mass spectrometry technique." Chinese Science Bulletin 42, no. 1 (January 1997): 30–33. http://dx.doi.org/10.1007/bf02882515.

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12

Rivlin, A. A. "Sorption technique in membrane-inlet mass spectrometry." Rapid Communications in Mass Spectrometry 9, no. 5 (1995): 397–99. http://dx.doi.org/10.1002/rcm.1290090507.

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13

Gould, Oliver, Natalia Drabińska, Norman Ratcliffe, and Ben de Lacy Costello. "Hyphenated Mass Spectrometry versus Real-Time Mass Spectrometry Techniques for the Detection of Volatile Compounds from the Human Body." Molecules 26, no. 23 (November 26, 2021): 7185. http://dx.doi.org/10.3390/molecules26237185.

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Mass spectrometry (MS) is an analytical technique that can be used for various applications in a number of scientific areas including environmental, security, forensic science, space exploration, agri-food, and numerous others. MS is also continuing to offer new insights into the proteomic and metabolomic fields. MS techniques are frequently used for the analysis of volatile compounds (VCs). The detection of VCs from human samples has the potential to aid in the diagnosis of diseases, in monitoring drug metabolites, and in providing insight into metabolic processes. The broad usage of MS has resulted in numerous variations of the technique being developed over the years, which can be divided into hyphenated and real-time MS techniques. Hyphenated chromatographic techniques coupled with MS offer unparalleled qualitative analysis and high accuracy and sensitivity, even when analysing complex matrices (breath, urine, stool, etc.). However, these benefits are traded for a significantly longer analysis time and a greater need for sample preparation and method development. On the other hand, real-time MS techniques offer highly sensitive quantitative data. Additionally, real-time techniques can provide results in a matter of minutes or even seconds, without altering the sample in any way. However, real-time MS can only offer tentative qualitative data and suffers from molecular weight overlap in complex matrices. This review compares hyphenated and real-time MS methods and provides examples of applications for each technique for the detection of VCs from humans.

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14

Lattimer, Robert P., and Robert E. Harris. "Analysis of Components in Rubber Compounds Using Mass Spectrometry." Rubber Chemistry and Technology 62, no. 3 (July 1, 1989): 548–67. http://dx.doi.org/10.5254/1.3536258.

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Abstract A large number of very successful mass-spectrometric methods have been developed for rubber-compound analysis. The high sensitivity, high specificity, and superb mixture analysis capabilities of modern mass spectrometry make it an invaluable tool in the polymer industry, particularly for qualitative identification of organic additives. In many cases, mass spectrometry can provide unique information that is not available by use of any other technique.

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Garcia, Xavier, Maria Sabaté, Jorge Aubets, Josep Jansat, and Sonia Sentellas. "Ion Mobility–Mass Spectrometry for Bioanalysis." Separations 8, no. 3 (March 16, 2021): 33. http://dx.doi.org/10.3390/separations8030033.

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This paper aims to cover the main strategies based on ion mobility spectrometry (IMS) for the analysis of biological samples. The determination of endogenous and exogenous compounds in such samples is important for the understanding of the health status of individuals. For this reason, the development of new approaches that can be complementary to the ones already established (mainly based on liquid chromatography coupled to mass spectrometry) is welcomed. In this regard, ion mobility spectrometry has appeared in the analytical scenario as a powerful technique for the separation and characterization of compounds based on their mobility. IMS has been used in several areas taking advantage of its orthogonality with other analytical separation techniques, such as liquid chromatography, gas chromatography, capillary electrophoresis, or supercritical fluid chromatography. Bioanalysis is not one of the areas where IMS has been more extensively applied. However, over the last years, the interest in using this approach for the analysis of biological samples has clearly increased. This paper introduces the reader to the principles controlling the separation in IMS and reviews recent applications using this technique in the field of bioanalysis.

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Dąbek, Józef, and Stanislaw Halas. "Physical Foundations of Rhenium-Osmium Method - A Review." Geochronometria 27, no. -1 (July 1, 2007): 23–26. http://dx.doi.org/10.2478/v10003-007-0011-4.

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Physical Foundations of Rhenium-Osmium Method - A Review A newly acquired mass spectrometer MI 1201 by the Mass Spectrometry Laboratory will be adapted to determine rhenium and osmium isotope concentrations using negative thermal ionization mass spectrometry (NTIMS). We describe the principle of the Re-Os dating technique and the thermal ionization phenomena which lead to high precision isotope analysis on NTIMS.

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17

Lu, I.-Chung. "Development of a Next-Generation Ionisation Technique in Mass Spectrometry." Impact 2022, no. 1 (February 4, 2022): 59–61. http://dx.doi.org/10.21820/23987073.2022.1.59.

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Mass spectrometry (MS) has a wide range of applications. Assistant Professor I-Chung Lu, Department of Chemistry, National Chung Hsing University, Taiwan, is working to improve and better understand aspects of MS in order to further broaden its possible applications. A particular focus for Lu and his team is on developing novel techniques or improving conventional ionisation methods to overcome application difficulties in MS, specifically in the detection of labile and unstable species. Those techniques extend the MS as a powerful tool to study critical reaction intermidiates and mechanisms. A novel ionisation technique called matrix-assisted ionisation (MAI) is another research focus for Lu and is something that he wants to shed greater light on due to its unclear ionisation process and potential for MS. Lu is seeking to enhance fundamental knowledge of spontaneously charge separation by studying ionisation processes in MAI. Lu and the team have combined a portable spectrometer and dedicated MAI source that has proven to directly detect drugs in urine and blood plasma rapidly. This fast-screen platform also has potential application to the diagnosis and clinical fields.

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Schmeer, Karl, Beate Behnke, and Ernst Bayer. "Capillary Electrochromatography-Electrospray Mass Spectrometry: A Microanalysis Technique." Analytical Chemistry 67, no. 20 (October 1995): 3656–58. http://dx.doi.org/10.1021/ac00116a007.

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19

Kieser, W. E., X. L. Zhao, C. Y. Soto, and B. Tracy. "Accelerator mass spectrometry of 129I: Technique and applications." Journal of Radioanalytical and Nuclear Chemistry 263, no. 2 (January 2005): 375–79. http://dx.doi.org/10.1007/s10967-005-0065-6.

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Karabagias, Ioannis K. "Advances of Spectrometric Techniques in Food Analysis and Food Authentication Implemented with Chemometrics." Foods 9, no. 11 (October 27, 2020): 1550. http://dx.doi.org/10.3390/foods9111550.

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Given the continuous consumer demand for products of high quality and specific origin, there is a great tendency for the application of multiple instrumental techniques for the complete characterization of foodstuffs or related natural products. Spectrometric techniques usually offer a full and rapid screenshot of products’ composition and properties by the determination of specific bio-molecules such as sugars, minerals, polyphenols, volatile compounds, amino acids, organic acids, etc. The present special issue aimed firstly to enhance the advances of the application of spectrometric techniques such as gas chromatography coupled to mass spectrometry (GC-MS), inductively coupled plasma optical emission spectrometry (ICP-OES), isotope ratio mass spectrometry (IRMS), nuclear magnetic resonance (NMR), Raman spectroscopy, or any other spectrometric technique, in the analysis of foodstuffs such as meat, milk, cheese, potatoes, vegetables, fruits/fruit juices, honey, olive oil, chocolate, and other natural products. An additional goal was to fill the gap between food composition/food properties/natural products properties and food/natural products authenticity, using supervised and non-supervised chemometrics. Of the 18 submitted articles, nine were eventually published, providing new information to the field.

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Thoren, Katie L. "Will Mass Spectrometry Replace Current Techniques for Both Routine Monitoring and MRD Detection in Multiple Myeloma?" Hemato 2, no. 4 (December 9, 2021): 764–68. http://dx.doi.org/10.3390/hemato2040052.

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In recent years, mass spectrometry has been increasingly used for the detection of monoclonal proteins in serum. Mass spectrometry is more analytically sensitive than serum protein electrophoresis and immunofixation, can help distinguish therapeutic monoclonal antibodies from M-proteins, and can detect the presence of post-translational modifications. Mass spectrometry also shows promise as a less-invasive, peripheral-blood-based test for detecting minimal residual disease in multiple myeloma. Studies comparing the clinical utility of mass spectrometry to current blood- and bone-marrow-based techniques have been conducted. Although still primarily limited to research settings, clinical laboratories are starting to adopt this technique for patient care. This review will discuss the current status of mass spectrometry testing for multiple myeloma, the benefits and challenges of this technique, and how it may be incorporated into clinical practice in the future.

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Helleur, R. J., and Pierre Thibault. "Optimization of pyrolysis–desorption chemical ionization mass spectrometry and tandem mass spectrometry of polysaccharides." Canadian Journal of Chemistry 72, no. 2 (February 1, 1994): 345–51. http://dx.doi.org/10.1139/v94-053.

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The operating conditions for pyrolysis–desorption ammonia chemical ionization mass spectrometry and tandem mass spectrometry have been optimized and the technique evaluated for the production and analysis of structurally-informative pyrolytic fragmentation ions corresponding to intact anhydrohexose oligosaccharides, using amylose as the model polysaccharide. Among the various parameters examined it was found that the nature of the solvent used to adhere the sample to the emitter coil and the configuration of the emitter and the rate at which it is heated all play important roles in determining the efficiency of the pyrolytic process and the production of high mass fragment ions. Adjustment of reagent gas pressure together with source temperature also influence the chemical integrity of high mass oligomeric pyrolysis products. Under optimal operating conditions using ammonia reagent gas, the analyses of cellulose, laminarin, agars, and chitin gave relatively abundant ions corresponding to ammonium (or protonated) adducts of up to anhydrohexose tetrasaccharide. More importantly, the generation of such higher mass fragment ions provided a sustained ionic current of sufficient duration to perform tandem mass spectrometric analyses.

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Carré, Vincent, Pierre Leroy, and Patrick Chaimbault. "Diagnosis of Biological Activities by Mass Spectrometry." Proceedings 11, no. 1 (April 29, 2019): 36. http://dx.doi.org/10.3390/proceedings2019011036.

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Oxidative reactions are vital but also cause important stresses and cellular damages resulting in cancers, cardiovascular or neurodegenerative diseases. Antioxidant secondary metabolites from plant can be mobilized for the cell defense and their main source is precisely the food intake such as vegetables, fruits or beverages. Screening natural active metabolites in plants requires different analytical techniques among which mass spectrometry became one of the most popular, not just because of its ability to provide structural information on involved molecules but also because this technique belongs to the arsenal of diagnostic tool for the determination of biological activities.

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SKIMS, Editor. "MALDI-TOF mass spectrometry in clinical diagnostic microbiology." JMS SKIMS 20, no. 1 (June 16, 2017): 54. http://dx.doi.org/10.33883/jms.v20i1.315.

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Microbial identification in clinical diagnostic laboratories mainly relies on conventional phenotypic and gene sequencing identification techniques. Recently development of matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) devices has revolutionized the routine identification of microorganisms in clinical microbiology laboratories. This is an easy, rapid, high throughput, low-cost, and efficient identification technique and has been adapted to the constraint of clinical diagnostic laboratories. This technology has the potential to replace and/or complement conventional identification techniques for both bacterial and fungal strains. JMS 2017; 20(1):54

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Urban, Pawel L. "Quantitative mass spectrometry: an overview." Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 374, no. 2079 (October 28, 2016): 20150382. http://dx.doi.org/10.1098/rsta.2015.0382.

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Mass spectrometry (MS) is a mainstream chemical analysis technique in the twenty-first century. It has contributed to numerous discoveries in chemistry, physics and biochemistry. Hundreds of research laboratories scattered all over the world use MS every day to investigate fundamental phenomena on the molecular level. MS is also widely used by industry—especially in drug discovery, quality control and food safety protocols. In some cases, mass spectrometers are indispensable and irreplaceable by any other metrological tools. The uniqueness of MS is due to the fact that it enables direct identification of molecules based on the mass-to-charge ratios as well as fragmentation patterns. Thus, for several decades now, MS has been used in qualitative chemical analysis. To address the pressing need for quantitative molecular measurements, a number of laboratories focused on technological and methodological improvements that could render MS a fully quantitative metrological platform. In this theme issue, the experts working for some of those laboratories share their knowledge and enthusiasm about quantitative MS. I hope this theme issue will benefit readers, and foster fundamental and applied research based on quantitative MS measurements. This article is part of the themed issue ‘Quantitative mass spectrometry’.

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Reusch, Nicola, Viola Krein, Nikolaus Wollscheid, and Karl-Michael Weitzel. "Distinction of Structural Isomers of Benzenediamin and Difluorobenzene by Means of Chirped Femtosecond Laser Ionization Mass Spectrometry." Zeitschrift für Physikalische Chemie 232, no. 5-6 (May 24, 2018): 689–703. http://dx.doi.org/10.1515/zpch-2017-1051.

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Abstract Structural isomers of disubstituted benzenes are difficult to distinguish with most mass spectrometric methods. Consequently, conventional concepts for the distinction of isomers are based on coupling mass spectrometry with a chromatographic method. As an alternative approach, we propose the combination of femtosecond laser ionization with time-of-flight mass spectrometry (fs-LIMS). The possibility of systematic tailoring of fs-laser pulse shapes opens access to a multidimensional analytical technique capable of distinguishing structural isomers of the title molecules.

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Weinkauf, R., K. Walter, C. Weickhardt, U. Boesl, and E. W. Schlag. "Laser Tandem Mass Spectrometry in a Time of Flight Instrument." Zeitschrift für Naturforschung A 44, no. 12 (December 1, 1989): 1219–25. http://dx.doi.org/10.1515/zna-1989-1216.

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Abstract We present a new laser tandem mass spectrometry technique in a reflectron time of flight (TOF) instrument. A first pulsed laser performs the multiphoton ionization and the primary photodissociation. A newly designed ion source permits a high mass resolution in the space focus of the 12 cm long first linear TOF, where then the secondary excitation can take place. For high resolution applications the pure secondary or pure metastable mass spectrum of a preselected precursor ion can be recorded using a new reflectron scanning technique. It is also possible to obtain the whole secondary mass spectrum with one cycle using a new postacceleration method. Several techniques for ejection of interfering ions are shown. The features of our techniques are demonstrated at various primary fragments of benzene.

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Gorshkov, Michael V., Christophe D. Masselon, Gordon A. Anderson, Harold R. Udseth, Richard Harkewicz, and Richard D. Smith. "A dynamic ion cooling technique for FTICR mass spectrometry." Journal of the American Society for Mass Spectrometry 12, no. 11 (November 2001): 1169–73. http://dx.doi.org/10.1016/s1044-0305(01)00306-3.

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BORMAN, STU. "New Technique Promises To Expand Scope of Mass Spectrometry." Chemical & Engineering News 69, no. 49 (December 9, 1991): 22–23. http://dx.doi.org/10.1021/cen-v069n049.p022.

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Kumar, Pankaj. "Accelerator Mass Spectrometry - an ultrasensitive dating and tracing technique." Journal of Physics: Conference Series 755 (October 2016): 012005. http://dx.doi.org/10.1088/1742-6596/755/1/012005.

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Adams, F., F. Michiels, M. Moens, and P. Van Espen. "Secondary-ion mass spectrometry as a quantitative microanalytical technique." Analytica Chimica Acta 216 (January 1989): 25–55. http://dx.doi.org/10.1016/s0003-2670(00)82003-6.

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Marshall, Alan G., and Lutz Schweikhard. "Fourier transform ion cyclotron resonance mass spectrometry: technique developments." International Journal of Mass Spectrometry and Ion Processes 118-119 (September 1992): 37–70. http://dx.doi.org/10.1016/0168-1176(92)85058-8.

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Vogel, Martin, and Uwe Karst. "Electrochemistry–mass spectrometry: an emerging hyphenated technique for bioanalysis." Analytical and Bioanalytical Chemistry 403, no. 2 (February 28, 2012): 333–34. http://dx.doi.org/10.1007/s00216-012-5863-4.

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Du, X. Y., X. Y. Liu, Z. Y. Shang, W. S. Han, and H. Zhang. "Detection techniques for monitoring dioxin-like compounds: latest techniques and the comparison." Journal of Physics: Conference Series 2045, no. 1 (October 1, 2021): 012024. http://dx.doi.org/10.1088/1742-6596/2045/1/012024.

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Abstract In order to clarify the necessity and urgency of dioxin detection, the characteristics and emission sources were firstly studied in this paper. The current dioxin detection techniques were then summarized, including chemical detection technique represented by HRGC/MS, biological detection technique covering immunology and biotechnology, and laser mass spectrometry technique using fusion ionization technology and time-of-flight mass spectrometry. Then the advantages and disadvantages, representative technologies, development directions and application prospects of various detection methods were analyzed. Eventually, the future development direction of dioxin detection technology was prospected.

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Lyapchenko, Natalya, Rafał Frański, and Grzegorz Schroeder. "Mass Spectrometric Investigation of Protonated and Cationized Molecules of Oxaalkyl Phosphates." European Journal of Mass Spectrometry 8, no. 6 (December 2002): 451–60. http://dx.doi.org/10.1255/ejms.512.

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Mass spectrometric fragmentation pathways of protonated molecules of oxaalkyl phosphates and their complexes with alkali metal cations are discussed in this paper. Liquid secondary ion mass spectrometry (LSIMS) was used as the ionisation technique and mass spectra from B/E linked scans were registered to elucidate the mass spectrometric decomposition of the studied ions. Mainly loss of the ether molecules H2C=HCOCH3 and HOH2C–H2COCH3 was observed. The elimination of neutrals containing metal, for example, K-CH2CH2OCH3 or KOCH2CH2OCH3 also occurred. In the case of phosphate (III) an unusual loss of two CH3CH2OCH3 molecules and a Li or Na atom was observed. Electrospray ionisation mass spectrometry (ESIMS) was applied in order to check the ability of the studied tripodands to form complexes with alkali metal cations.

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Linton, Richard W. "Direct Imaging of Trace Elements, Isotopes, and Molecules Using Mass Spectrometry." Microscopy and Microanalysis 4, S2 (July 1998): 124–25. http://dx.doi.org/10.1017/s1431927600020742.

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Secondary ion mass spectrometry (SIMS) is based upon the energetic ion bombardment of surfaces resulting in in the emission of sputtered particles, including both atomic and molecular ions. The use of mass spectrometric detection provides a highly versatile and sensitive tool for surface and thin film microanalysis. The scope of the technique includes a diversity of analysis modes including:1.Elemental Depth Profiling (dynamic SIMS),2.Laterally Resolved Imaging (ion microprobe or ion microscope analysis),3.Image Depth Profiling (combination of modes 1 and 2 providing 3-D images),4.Molecular Monolayer Analysis and Imaging (static SIMS),5.Sputtered Neutral Mass Spectrometry (post-ionization).Much of the early work in dynamic SIMS centered on depth profiling and imaging techniques, with an emphasis on applications to electronic materials. SIMS has made extensive contributions to semiconductor materials science since the 1960's, including the development of new devices and processes, and in failure analysis.

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Gove, Harry E. "Some Comments on Accelerator Mass Spectrometry." Radiocarbon 42, no. 1 (2000): 127–35. http://dx.doi.org/10.1017/s0033822200053091.

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This paper discusses some aspects of the development of accelerator mass spectrometry (AMS), the international conferences that have been held, and the books that have been written on the subject. It also mentions some details of the technique and its strengths. Some of the interesting measurements that have been made recently are covered, and finally, it presents some thoughts on future developments.

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Daniel, Yvonne, and Charles Turner. "Newborn Sickle Cell Disease Screening Using Electrospray Tandem Mass Spectrometry." International Journal of Neonatal Screening 4, no. 4 (November 24, 2018): 35. http://dx.doi.org/10.3390/ijns4040035.

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There is a growing demand for newborn sickle cell disease screening globally. Historically techniques have relied on the separation of intact haemoglobin tetramers using electrophoretic or liquid chromatography techniques. These techniques also identify haemoglobin variants of no clinical significance. Specific electrospray ionization-mass spectrometry-mass spectrometry techniques to analyse targeted peptides formed after digestion of the haemoglobin with trypsin were reported in 2005. Since this time the method has been further developed and adopted in several European countries. It is estimated that more than one million babies have been screened with no false-negative cases reported. This review reports on the current use of the technique and reviews the related publications.

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Linton, Richard W. "Secondary ion mass spectroscopy in the biological and materials sciences." Proceedings, annual meeting, Electron Microscopy Society of America 51 (August 1, 1993): 498–99. http://dx.doi.org/10.1017/s0424820100148320.

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Secondary ion mass spectrometry (SIMS) is based upon energetic ion bombardment of surfaces resulting in in the emission of sputtered particles, including both atomic and molecular ions. The use of mass spectrometric detection provides a highly versatile and sensitive tool for surface and thin film chemical analysis. In recent years, the scope of the technique has broadened to include a variety of analysis modes including:1.Elemental Depth Profiling (dynamic SIMS),2.Laterally Resolved Imaging (ion microprobe or ion microscope analysis),3.Image Depth Profiling (combination of modes 1 and 2 providing 3-D images),4.Molecular Monolayer Analysis (static SIMS),5.Sputtered Neutral Mass Spectrometry (post-ionization).Much of the early work in dynamic SIMS centered on the development of depth profiling and imaging techniques, with an emphasis on applications to electronic materials. SIMS has made extensive contributions to semiconductor materials science since the 1960's, including the development of new devices and processes, and in failure analysis.

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Rainville, S., J. K. Thompson, and D. E. Pritchard. "Single-ion mass spectrometry at 100 ppt and beyond." Canadian Journal of Physics 80, no. 11 (November 1, 2002): 1329–36. http://dx.doi.org/10.1139/p02-108.

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Using a Penning trap single-ion mass spectrometer, we measured the atomic masses of 14 isotopes with a fractional accuracy of ~1010. The precision on these measurements was limited by the temporal fluctuations of our magnetic field. By trapping two different ions in the same Penning trap at the same time, we have recently been able to virtually eliminate that source of error. We can now simultaneously measure the ratio of the two ion's cyclotron frequencies (from which we obtain their atomic mass ratio) with a precision of about 1011 in only a few hours. To perform these comparisons, we must be able to measure and control all three normal modes of motion of each ion cyclotron, axial, and magnetron and have developed novel techniques to do so. This new technique shows promise of expanding the precision of mass spectrometry by an order of magnitude beyond the current state-of-the-art. PACS Nos.: 32.10Bi, 06.20Jr, 06.30Dr, 07.75+h, 07.77-n

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Bolla, Jani Reddy, Mark T. Agasid, Shahid Mehmood, and Carol V. Robinson. "Membrane Protein–Lipid Interactions Probed Using Mass Spectrometry." Annual Review of Biochemistry 88, no. 1 (June 20, 2019): 85–111. http://dx.doi.org/10.1146/annurev-biochem-013118-111508.

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Membrane proteins that exist in lipid bilayers are not isolated molecular entities. The lipid molecules that surround them play crucial roles in maintaining their full structural and functional integrity. Research directed at investigating these critical lipid–protein interactions is developing rapidly. Advancements in both instrumentation and software, as well as in key biophysical and biochemical techniques, are accelerating the field. In this review, we provide a brief outline of structural techniques used to probe protein–lipid interactions and focus on the molecular aspects of these interactions obtained from native mass spectrometry (native MS). We highlight examples in which lipids have been shown to modulate membrane protein structure and show how native MS has emerged as a complementary technique to X-ray crystallography and cryo–electron microscopy. We conclude with a short perspective on future developments that aim to better understand protein–lipid interactions in the native environment.

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Unsihuay, Daisy, Daniela Mesa Sanchez, and Julia Laskin. "Quantitative Mass Spectrometry Imaging of Biological Systems." Annual Review of Physical Chemistry 72, no. 1 (April 20, 2021): 307–29. http://dx.doi.org/10.1146/annurev-physchem-061020-053416.

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Mass spectrometry imaging (MSI) is a powerful, label-free technique that provides detailed maps of hundreds of molecules in complex samples with high sensitivity and subcellular spatial resolution. Accurate quantification in MSI relies on a detailed understanding of matrix effects associated with the ionization process along with evaluation of the extraction efficiency and mass-dependent ion losses occurring in the analysis step. We present a critical summary of approaches developed for quantitative MSI of metabolites, lipids, and proteins in biological tissues and discuss their current and future applications.

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Chen, Chun-Chi, and Po-Chiao Lin. "Monitoring of chemical transformations by mass spectrometry." Analytical Methods 7, no. 17 (2015): 6947–59. http://dx.doi.org/10.1039/c5ay00496a.

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Karas, Michael. "Laser Microprobe Mass Spectrometry for Spatially Resolved Organic Analysis." Proceedings, annual meeting, Electron Microscopy Society of America 48, no. 2 (August 12, 1990): 306–7. http://dx.doi.org/10.1017/s0424820100135137.

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Within the last twenty years, lasers were used for sample ionization in mass spectrometry by coupling nearly any available type of laser to the different kinds of available mass analyzers. There is a broad area of applications of the so-called laser ionization/desorption mass spectrometry (LIMS, LDMS) in a large variety of fields, such as geology, mineralogy, material research, general chemistry and biochemistry ranging from determination of bulk elemental composition to molecular weight determination of biological macromolecules. By combining an UV-microscope with a short-pulse UV-laser (for sample observation and focused irradiation of selected sample areas within μm-resolution) and a time-of-flight mass spectrometer, the technique of laser microprobe mass spectrometry was established (LAMMA-, LIMAtechnique). Also laser microprobe mass spectrometry was applied in very different fields. Most of the work dealt with the determination of element distributions within biological samples, usually prepared as thin sections and examined with a transmission geometry, i.e. by perforating the compartment of sample to be analyzed with a high intensity laser beam.

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Makarov, V. A., and T. K. Savosteenko. "Determination of phosphorus mass fraction in steels of plasma atomic emission spectrometry." Litiyo i Metallurgiya (FOUNDRY PRODUCTION AND METALLURGY), no. 1 (March 26, 2021): 86–90. http://dx.doi.org/10.21122/1683-6065-2021-1-86-90.

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A method for measuring the mass fraction of phosphorus in steels by atomic emission spectrometry with the inductively coupled plasma (AES-ICP) has been developed. Possibilities of atomic emission spectrometers of iCAP series for determination of phosphorus in steels allowing to reduce considerably duration of the analysis and to increase its profitability in comparison with chemical methods of the analysis are investigated. A method of decomposition of steel for the complete transfer of phosphorus into solution is proposed. The possibility of software spectrometers “iTeva” in the analysis by the method of relative concentrations. Calibration of the spectrometer was carried out on aqueous solutions with a known concentration of phosphorus using the method of relative concentrations. For the preparation of calibration solutions, chemically pure salt was used. The analytical line free from spectral overlays is selected. A good correlation of the calibration graph is obtained. The correctness of the determination is confirmed by the analysis of standard samples and comparison with the results of the determination in accordance with the chemical method. The developed technique is used in determining the mass fraction of phosphorus in steels. Validation of the methodology was carried out. iCAP spectrometers can be used to determine the mass fraction of phosphorus in steels.

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Kaiser, U., and J. C. Huneke. "Fundamentals of Sputtered Neutral Mass Spectrometry." MRS Bulletin 12, no. 6 (September 1987): 48–51. http://dx.doi.org/10.1557/s0883769400067221.

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AbstractSputtered neutral mass spectrometry (SNMS) is a technique for elemental and isotopic analysis with excellent detection limits, with similar sensitivity for all elements and without substantial matrix effects. Particles sputter atomized from the sample surface are ionized and mass spectrometrically measured. Elemental detection limits are routinely 1–10 ppm, but can be as low as 1–10 ppb. Particular modes of SNMS enable the measurement of accurate concentration depth profiles with resolutions approaching 20 Å and the measurement of electrically insulating samples.

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Zhukov, Andrei, Jos Buijs, and Detlev Suckau. "Adding function to characterization: Combining mass spectrometry with surface plasmon resonance." Biochemist 24, no. 3 (June 1, 2002): 21–23. http://dx.doi.org/10.1042/bio02403021.

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Since Sir J.J. Thomson of the Cavendish Laboratory at the University of Cambridge constructed the first mass spectrometer (then called a parabola spectrograph) at the turn of the last century, mass spectrometry (MS) has become the most ubiquitous analytical technique in use today. It represents a powerful tool in the study of all substances, because it provides more information about the composition and structure of a substance from a smaller amount of sample than any other analytical technique. It is also a powerful quantitative tool. Femtograms (10 15 g) of carcinogenic pesticide residues can be quantitated and identified in foodstuffs, whereas a genetic abnormality can be characterized from mere femtomole (10 15 mol) quantities of a protein.

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Cercola, Rosaria, Natalie G. K. Wong, Chris Rhodes, Lorna Olijnyk, Neetisha S. Mistry, Lewis M. Hall, Jacob A. Berenbeim, Jason M. Lynam, and Caroline E. H. Dessent. "A “one pot” mass spectrometry technique for characterizing solution- and gas-phase photochemical reactions by electrospray mass spectrometry." RSC Advances 11, no. 32 (2021): 19500–19507. http://dx.doi.org/10.1039/d1ra02581c.

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Ma, Xin. "Recent Advances in Mass Spectrometry-Based Structural Elucidation Techniques." Molecules 27, no. 19 (September 30, 2022): 6466. http://dx.doi.org/10.3390/molecules27196466.

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Mass spectrometry (MS) has become the central technique that is extensively used for the analysis of molecular structures of unknown compounds in the gas phase. It manipulates the molecules by converting them into ions using various ionization sources. With high-resolution MS, accurate molecular weights (MW) of the intact molecular ions can be measured so that they can be assigned a molecular formula with high confidence. Furthermore, the application of tandem MS has enabled detailed structural characterization by breaking the intact molecular ions and protonated or deprotonated molecules into key fragment ions. This approach is not only used for the structural elucidation of small molecules (MW < 2000 Da), but also crucial biopolymers such as proteins and polypeptides; therefore, MS has been extensively used in multiomics studies for revealing the structures and functions of important biomolecules and their interactions with each other. The high sensitivity of MS has enabled the analysis of low-level analytes in complex matrices. It is also a versatile technique that can be coupled with separation techniques, including chromatography and ion mobility, and many other analytical instruments such as NMR. In this review, we aim to focus on the technical advances of MS-based structural elucidation methods over the past five years, and provide an overview of their applications in complex mixture analysis. We hope this review can be of interest for a wide range of audiences who may not have extensive experience in MS-based techniques.

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Liu, Shulei, and Benjamin L. Schulz. "Biopharmaceutical quality control with mass spectrometry." Bioanalysis 13, no. 16 (August 2021): 1275–91. http://dx.doi.org/10.4155/bio-2021-0123.

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Mass spectrometry (MS) is a powerful technique for protein identification, quantification and characterization that is widely applied in biochemical studies, and which can provide data on the quantity, structural integrity and post-translational modifications of proteins. It is therefore a versatile and widely used analytic tool for quality control of biopharmaceuticals, especially in quantifying host-cell protein impurities, identifying post-translation modifications and structural characterization of biopharmaceutical proteins. Here, we summarize recent advances in MS-based analyses of these key quality attributes of the biopharmaceutical development and manufacturing processes.

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