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Relevant bibliographies by topics / Mass spectometry

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Academic literature on the topic 'Mass spectometry'

Author: Grafiati

Published: 4 June 2021

Last updated: 20 February 2023

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Journal articles on the topic "Mass spectometry"

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Santos, Lúcia, Jorge Barbosa, M. Conceição Castilho, Fernando Ramos, Carlos A. Fontes Ribeiro, and M. Irene Noronha da Silveira. "Determination of chloramphenicol residues in rainbow trouts by gas chromatography–mass spectometry and liquid chromatography–tandem mass spectometry." Analytica Chimica Acta 529, no. 1-2 (January 2005): 249–56. http://dx.doi.org/10.1016/j.aca.2004.07.017.

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Valentine, Stephen J., Xiaoyun Liu, Manolo D. Plasencia, Amy E. Hilderbrand, Ruwan T. Kurulugama, Stormy L. Koeniger, and David E. Clemmer. "Developing liquid chromatography ion mobility mass spectometry techniques." Expert Review of Proteomics 2, no. 4 (August 2005): 553–65. http://dx.doi.org/10.1586/14789450.2.4.553.

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Schweikhard, Lutz. "Excitation and detection geometries for Fourier-transform mass spectometry." Rapid Communications in Mass Spectrometry 8, no. 1 (January 1994): 10–13. http://dx.doi.org/10.1002/rcm.1290080103.

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Crighton, Jim. "Inductively coupled and microwave induced plasma sources for mass spectometry." TrAC Trends in Analytical Chemistry 15, no. 7 (August 1996): X. http://dx.doi.org/10.1016/0165-9936(96)83728-9.

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Chace, Donald H., Roser Pons, Claudia A. Chiriboga, Donald J. McMahon, Ingrid Tein, Edwin W. Naylor, and Darryl C. De Vivo. "Neonatal Blood Carnitine Concentrations: Normative Data by Electrospray Tandem Mass Spectometry." Pediatric Research 53, no. 5 (May 2003): 823–29. http://dx.doi.org/10.1203/01.pdr.0000059220.39578.3d.

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Wilson, Stephen R., and Yunhui Wu. "Selective alkali metal binding of valinomycin by electrospray ionization mass spectometry." Supramolecular Chemistry 3, no. 4 (July 1994): 273–77. http://dx.doi.org/10.1080/10610279408034926.

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Křen, Vladimír, and Tomáš Řezanka. "Sterols and fatty acids in Peziza muralis." Canadian Journal of Microbiology 42, no. 11 (November 1, 1996): 1176–78. http://dx.doi.org/10.1139/m96-150.

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Composition of sterols and fatty acids in fruiting bodies of fungus Peziza muralis were determined by gas chromatography – mass spectometry. Sterol distribution (e.g., brassicasterol occurrence) confirms phylogenetic relations to the order Tuberales. Nontypical lipid composition reflects extreme conditions (e.g., sunny, dry, and mineral-rich niches) where this fungus occurs.Key words: Peziza muralis, lipids, sterols, brassicasterol, fatty acids.

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KADOWAKI, Satoshi, and Hirotaka NAITOH. "Determination of ethylthiometon residues in environmental samples by gas chromatography/mass spectometry." Journal of Environmental Chemistry 3, no. 4 (1993): 747–59. http://dx.doi.org/10.5985/jec.3.747.

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Hallégot, P., C. Girod, M. M. Le Beau, and R. Levi-Setti. "Direct nucleotide mapping of human chromosomes by imaging Secondary Ion Mass Spectometry." Proceedings, annual meeting, Electron Microscopy Society of America 48, no. 3 (August 12, 1990): 114–15. http://dx.doi.org/10.1017/s042482010015811x.

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The relationship between chromosome banding patterns obtained by a variety of staining methods (G,Q,R, and C) and the actual nucleotide content of the different bands, has been the subject of extensive investigations over the past 20 years and has been critically reviewed. Although a number of in vitro experiments have shown preference of certain stains for specific bases, the presence of proteins in chromosomes and their interaction with the DNA, has to some extent obscured a direct correlation between banding patterns and base content. Even the widely useful differential staining following substitution of the thymidine in DNA by the analog bromodeoxyuridine (BrdU), is not independent of the presence of proteins. Clearly, it would be desirable to examine physical methods capable of assessing DNA base composition in chromosomes, free of chemical interactions. One of these methods, already successfully applied involves the 3H-labelling of nucleotides and subsequent detection by autoradiography. An alternative approach, the subject of this report, is capable of attaining much improved spatial resolution and consists of the detection of isotope-labelled nucleotides by secondary ion mass spectrometry (SIMS).

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Schwartz, Brenda L., Alan L. Rockwood, Richard D. Smith, Donald A. Tomalia, and Ralph Spindler. "Detection of high molecular weight starburst dendrimers by electrospray ionization mass spectometry." Rapid Communications in Mass Spectrometry 9, no. 15 (1995): 1552–55. http://dx.doi.org/10.1002/rcm.1290091516.

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Dissertations / Theses on the topic "Mass spectometry"

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De, Jager Lionel Louis. "Permanent modifiers for electrothermal atomization atomic absorption spectometry." Diss., Access to E-Thesis, 2000. http://upetd.up.ac.za/thesis/available/etd-11162006-161158/.

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Gudi, Girish Srinivas. "Study of oligonucleotide-polyamine noncovalent complexes by ESI-ion trap mass spectometry." Morgantown, W. Va. : [West Virginia University Libraries], 2001. http://etd.wvu.edu/templates/showETD.cfm?recnum=2029.

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Thesis (Ph. D.)--West Virginia University, 2001.
Title from document title page. Document formatted into pages; contains xiii, 165 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 157-165).

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Hoffman, Michael David. "Method development for the comprehensive analysis of post translational modifications by mass spectometry." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/1051.

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Signal Transduction is mediated by protein complexes whose spatial- and temporal-distribution, composition and function within cells are often regulated by different post-translational modifications (PTM). As PTMs add or subtract a specific mass difference to a protein, mass spectrometry becomes very amenable for modification analysis. These modifications have conventionally been monitored by fragmenting the modified protein or peptide by collision induced dissociation (CID) within the mass spectrometer, and then screening for the characteristic neutral fragment or fragment ion (marker ion), which is particular to the modification in question. Unfortunately, there are two major issues with respect to the traditional mass spectrometric analysis of PTMs: (1) as there are over 300 known types of modifications, the characteristic fragmentation of only a fraction of these modifications has been studied and (2) the traditional mass spectrometric approaches can only monitor these modifications sequentially, and thus comprehensive modification analysis would be unfeasible considering the breadth of PTMs. The following work aims to address these issues by (1) analyzing PTMs that have never been characterized mass spectrometrically and (2) developing a multiplexed technique for comprehensive PTM monitoring by simultaneously screening for all known characteristic fragments. With respect to the first issue, the characteristic fragmentation of lipid modifications and HNO-induced modifications was investigated. The most prevalent indicator(s) of the modification within the mass spectra are as follows: fragmentation of N-terminal myristoylated peptides produced marker ions at 240 and 268 Th, fragmentation of cysteine farnesylated peptides produced a marker ion at 205 Th and a neutral fragment of 204 Da, and fragmentation of cysteine palmitoylated peptides produced a neutral fragment of 272 Th. For HNO-induced modifications, fragmentation of the sulfinamide- and sulfinic acid-modified peptides produced a neutral fragment of 65 Da and 66 Da, respectively. With respect to the second issue, a multiplexed technique for monitoring modifications that fragment as neutral losses, termed Multiple Neutral Loss Monitoring (MNM), has been developed, successfully validated, and then shown to be the most sensitive approach for PTM analysis. MNM, combined with a second multiplexed approach, targeted Multiple Precursor Ion Monitoring, has been used to provide a comprehensive PTM analysis.

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Montalbani, Simona <1968&gt. "Pyrolysis-Gas Chromatography-Mass Spectometry and Chemometric Analysis for the Characterization of Complex Matrices." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amsdottorato.unibo.it/4559/.

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The present PhD thesis was focused on the development and application of chemical methodology (Py-GC-MS) and data-processing method by multivariate data analysis (chemometrics). The chromatographic and mass spectrometric data obtained with this technique are particularly suitable to be interpreted by chemometric methods such as PCA (Principal Component Analysis) as regards data exploration and SIMCA (Soft Independent Models of Class Analogy) for the classification. As a first approach, some issues related to the field of cultural heritage were discussed with a particular attention to the differentiation of binders used in pictorial field. A marker of egg tempera the phosphoric acid esterified, a pyrolysis product of lecithin, was determined using HMDS (hexamethyldisilazane) rather than the TMAH (tetramethylammonium hydroxide) as a derivatizing reagent. The validity of analytical pyrolysis as tool to characterize and classify different types of bacteria was verified. The FAMEs chromatographic profiles represent an important tool for the bacterial identification. Because of the complexity of the chromatograms, it was possible to characterize the bacteria only according to their genus, while the differentiation at the species level has been achieved by means of chemometric analysis. To perform this study, normalized areas peaks relevant to fatty acids were taken into account. Chemometric methods were applied to experimental datasets. The obtained results demonstrate the effectiveness of analytical pyrolysis and chemometric analysis for the rapid characterization of bacterial species. Application to a samples of bacterial (Pseudomonas Mendocina), fungal (Pleorotus ostreatus) and mixed- biofilms was also performed. A comparison with the chromatographic profiles established the possibility to: • Differentiate the bacterial and fungal biofilms according to the (FAMEs) profile. • Characterize the fungal biofilm by means the typical pattern of pyrolytic fragments derived from saccharides present in the cell wall. • Individuate the markers of bacterial and fungal biofilm in the same mixed-biofilm sample.

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Perkins, Deborah Davidson. "Characterization and applications of the monodisperse aerosol generation interface for combining liquid chromatography with mass spectometry." Diss., Georgia Institute of Technology, 1988. http://hdl.handle.net/1853/27610.

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Wickramasekara, Samanthi. "Mass Spectometry Based Identification of Proteins in Burkholderia Species and in the Blood Meal of Ticks." Diss., The University of Arizona, 2008. http://hdl.handle.net/10150/195155.

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Burkholderia pseudomallei is the causative agent of Melioidosis, an endemic disease in South East Asia, and is classified as a category B biological agent. Currently, there is no licensed vaccine for this disease; the mortality rate is high due to the incorrect diagnosis and the pathogen insusceptibility to general antibiotics. A mass spectrometry based proteomic approach has been applied in order to identify the proteins that are responsible for pathogenicity.Methods were developed for the proteomic analysis of Burkholderia species using B. vietnamiensis G4, an opportunistic pathogen as the model organism. Both gel-based (LC-MS/MS) and gel-free MudPIT (LC/LC-MS/MS) approaches have been applied for the analysis of the proteins extracted from four different cellular fractions of these bacteria. More than 1200 proteins were identified from these analyses, including many proteins previously identified as virulence factors of these bacteria. Similar methodologies were applied to build a proteome map of non-pathogenic B. thailandensis E264 to use as a reference for the pathogenic studies. Additionally, proteomes of two B. thailandensis strains isolated from two geographical locations were compared to investigate the differences in protein expression of these organisms.Proteins identified from pathogenic B. pseudomallei were compared with the non-pathogenic B. thailandensis and opportunistic pathogen B. vietnamiensis proteins. Many species specific proteins were identified from this proteomic analyses; those proteins can be used as antigen targets to selectively identify these pathogenic bacteria in a complex biological matrix using affinity capture methods.Ticks are vectors that can transmit disease causing pathogens one host to another. Knowing the pathogen reservoir is important in order to control disease spread in the environment. Application of mass spectrometric methods to identify the host blood components from tick vectors was investigated using tick nymphs which feed only once in their life cycle. Using mass spectrometry based proteomics; host specific proteins like hemoglobin and immunoglobulin were identified from a single tick nymph analysis. Additional studies have examined the fatty acid profiles of rabbit and sheep blood fed tick nymphs using SPALDI mass spectrometry. Different fatty acid profiles were obtained for these tick nymphs, but further investigations are required to validate these findings.

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Miller, Joseph. "Direct Multielemental Analysis of Solid Samples Using Laser Ablation Inductively Coupled Plasma Mass Spectometry and Pulsed Radio Frequency Glow Discharge Mass Spectrometry." TopSCHOLAR®, 2003. http://digitalcommons.wku.edu/theses/556.

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Direct solid sampling is an area of analytical research that has generated a large amount of interest in recent years. Two analysis systems offering fast and nondestructive methods of determining the elemental composition of substances, without requiring complicated sample preparation procedures, are laser ablation inductively coupled plasma mass spectroscopy (LA-ICPMS) and radio frequency glow discharge mass spectroscopy (rf-GDMS). A Cetac LSX-200 laser system coupled to a LECO Renaissance ICPMS was utilized to analyze coal and ash samples prepared by incorporation into a lithium borate matrix to form a disk. In addition, a VG 9000 Glow Discharge Mass Spectrometer (GDMS) with Nier-Johnson reverse ion optic geometry, equipped with a radio frequency source (rf-source), was used for the determination of nonconductors or insulators in addition to the normal metals and semiconductors previously determined by dc-source analysis. Further addition of a pulse generator to the rf-source resulted in a variable duty cycle, allowing greater ionization efficiency without the risk of catastrophic damage to the sample. The results of this research indicate that the LA-ICPMS system can be used to directly determine the composition of ash samples, with further method development, and that the Prf-GDMS system can be used successfully to analyze nonconductive solid samples including bone tissue.

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Oduwole, Elizabeth O. "Generation of a database of mass spectra patterns of selected Mycobacterium species using MALDI-ToF mass spectrometry." Thesis, Stellenbosch : Stellenbosch University, 2008. http://hdl.handle.net/10019.1/2838.

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Thesis (MScMedSc (Pathology. Medical Microbiology))--Stellenbosch University, 2008.
The genus Mycobacterium is a group of acid–fast, aerobic, slow- growing organisms which include more than 90 different species. A member of this genus, Mycobacterium tuberculosis, belonging to the Mycobacterium tuberculosis complex (MTB), is the causative agent of tuberculosis (TB). This disease is currently considered a global emergency, with more than 2 million deaths and over 8 million new cases annually. TB is the world’s second most common cause of death after HIV/AIDS. About one-third of the world’s population is estimated to be infected with TB. This catastrophic situation is further compounded by the emergence of Multi Drug Resistant tuberculosis (MDR-TB) and in more recent times, Extensive Drug Resistant tuberculosis (XDR-TB). Early diagnosis is critical to the successful management of patients as it allows informed use of chemotherapy. Also, early diagnosis is also of great importance if the menace of MDR-TB and XDR-TB is to be curbed and controlled. As MTB is highly infectious for humans, it is of paramount importance that TB be diagnosed as early as possible to stop the spread of the disease. Traditional conventional laboratory procedures involving microscopy, culture and sensitivity tests may require turnaround times of 3-4 weeks or longer. Tremendous technological advancement over the years such as the advent of automated liquid culture systems like the BACTEC® 960 and the MGITTM Tube system, and the development of a myriad of molecular techniques most of which involves nucleic acid amplification (NAA) for the rapid identification of mycobacterial isolates from cultures or even directly from clinical specimens have contributed immensely to the early diagnosis of tuberculosis. Most of these NAA tests are nevertheless fraught with various limitations, thus the search for a rapid, sensitive and specific way of diagnosing tuberculosis is still an active area of research. The search has expanded to areas that would otherwise not have been considered ‘conventional’ in diagnostic mycobacteriology. One of such areas is mass spectrometry. This study joins the relatively few studies of its kind encountered in available literature to establish the ground work for the application of mass spectrometry, specifically Matrix Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-ToF MS) in the field of diagnostic mycobacteriology. This is an area which is in need of the speed, sensitivity and specificity that MALDI-ToF technique promises to offer. Since this technology is still in its infancy, the use of utmost care in the preparation of reagents, and the handling and storage of the organisms used to generate reference mass spectra for the database cannot be overemphasized. Similarly, the optimization of certain crucial experimental factors such as inactivating method and choice of matrix is of paramount importance. The main aim of this thesis was to generate a database of reference mass spectra fingerprints of selected (repository) Mycobacterium species. This necessitated the standardization of an experimental protocol which ensured that experimental factors and the various instrument parameters were optimized for maximum spectra generation and reproducibility. A standard operating procedure (SOP) for generating the database of reference mass spectra finger print of selected Mycobacterium species was developed and used to investigate the ability of the database to differentiate between species belonging to the same clinical disease complex as well as the nontuberculosis complex. The findings of this study imply that if the defined protocol is followed, the database generated has the potential to routinely identify and differentiate (under experimental conditions) more species of Mycobacterium than is currently practical using PCR and its related techniques. It is therefore a realistic expectation that when the database is clinically validated and tested in the next phase of the study, it will contribute immensely to the diagnosis of tuberculosis and other mycobacterioses. It will also aid in the identification of emerging pathogens particularly amongst the non-tuberculous mycobacteria.

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Sivarajah, Vinothini. "Evaluation of NMR spectroscopy and liquid chromatography-mass spectometry (LC-MS) as analytical platforms for human metabolic phenotyping." Thesis, Imperial College London, 2009. http://hdl.handle.net/10044/1/8163.

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This thesis evaluates the ability of ¹H nuclear magnetic resonance (NMR) spectroscopic and ultra performance liquid chromatography-mass spectrometry (UPLC-MS) strategies to extract latent biochemical information from complex biofluid matrices from animal models and humans. ¹H NMR spectroscopy was applied to urine samples to investigate time-dependent biochemical changes in acid-base balance studies of metabolic alkalosis and metabolic acidosis and in a study of caloric restriction in order to establish normal physiological variation in organic acids including tricarboxylic acid (TCA) cycle intermediates. A method for profiling organic acids in human urine was developed, optimised and validated using UPLC-MS and then applied to targeted and untargeted metabolic profiling. A combined approach using both techniques was then applied in order to assess the relative efficiencies and merits of ¹H NMR spectroscopy and UPLC-MS for diagnosis of unknown inborn errors of metabolism (IEM) diseases using human urine samples in a blind fashion. Both NMR and UPLC-MS analytical platforms detected and identified all of the IEM correctly and revealed complementary biochemical information from IEM and controls. This evaluation was further extended and scaled up to assess the capability of the technologies for extracting latent biological information from urine samples collected in a large human population study. Chemometric methods such as Principal Component Analysis (PCA) and Orthogonal Projection to Latent Structure Discriminant Analysis (O-PLS-DA) were used to interpret and compare the two spectroscopic data types. These statistical methodologies allowed the detection of population specific biomarkers and the establishment of key metabolic phenotype differences in selected populations. In particular, both analytical approaches were able to discriminate Icelandic participants from other populations. The methods developed as part of this project should prove useful in widespread metabonomic applications in pharmaceutical and disease related areas.

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Kannamkumarath, Sasi S. "Trace elemental speciation using chromatography/capillary electrophoresis coupled to inductively coupled plasma mass spectometry for food, pharmaceutical and environmental analysis." Cincinnati, Ohio : University of Cincinnati, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=ucin1085673299.

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Books on the topic "Mass spectometry"

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Akler, Matthew. A study in atmospheric pressure chemical ionization mass spectometry. Ottawa: National Library of Canada, 1990.

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Smith, S. M. Sputtered neutral mass spectometry using electron beamanddischarge post ionisation. Manchester: UMST, 1994.

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Canry, J. C. Static secondary ion mass spectometry study of oxygen plasma treatment of polypropylene. Manchester: UMIST, 1993.

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Wyplosz, Nicolas. Laser desorption mass spectometric studies of artists' organic pigments. [Amsterdam]: Universiteit van Amsterdam, 2003.

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(Editor), John N. Abelson, Melvin I. Simon (Editor), and James A. McCloskey (Editor), eds. Mass Spectrometry: Volume 193: Mass Spectometry (Methods in Enzymology). Academic Press, 1990.

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Great Britain. Health and Safety Executive. Health and Safety Laboratory. and Great Britain. Health and Safety Executive., eds. Dimethyl sulphate and diethyl sulphate in air: Laboratory method using thermal desorption, gas chromatography-mass spectometry. Sudbury: HSE Books, 1998.

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Ewing, Nigel Phillip. Conformational and structural elucidation of negative and positive ions in the gas phase employing Fourier tranform ion cyclotron resonance mass spectometry. 1999.

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Book chapters on the topic "Mass spectometry"

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Grey, Angus C., and Kevin L. Schey. "Chapter 18. MALDI Mass Spectometry Imaging for Eye Diseases." In MALDI Mass Spectrometry Imaging, 432–56. Cambridge: Royal Society of Chemistry, 2021. http://dx.doi.org/10.1039/9781839165191-00432.

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Marchetti-Deschmann, Martina. "Chapter 19. Correlative Multimodal Mass Spectometry Imaging – Imaging Across the Scales." In MALDI Mass Spectrometry Imaging, 457–76. Cambridge: Royal Society of Chemistry, 2021. http://dx.doi.org/10.1039/9781839165191-00457.

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Conference papers on the topic "Mass spectometry"

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Ryabinin, I. A., and N. V. Vasilyeva. "NOVEL BIOMARKERS OF INVASIVE ASPERGILLOSIS CAUSATIVE AGENTS FROM SPECTRA-FORMING MOLECULES REVEALING BY LINEAR MALDI-TOF MASS-SPECTOMETRY." In Molecular Diagnostics and Biosafety. Federal Budget Institute of Science 'Central Research Institute for Epidemiology', 2020. http://dx.doi.org/10.36233/978-5-9900432-9-9-223.

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Farmer, C. B., J. W. Brault, A. Goldman, D. E. Hinton, F. J. Murcray, D. E. Jennings, J. J. Puschell, C. P. Rinsland, W. A. Traub, and M. C. Abrams. "On the Design of Fourier Transform Spectrometers for Space-based Remote Sensing." In Fourier Transform Spectroscopy. Washington, D.C.: Optica Publishing Group, 2022. http://dx.doi.org/10.1364/fts.1997.pdp.1.

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After some four decades of development, Fourier transform spectrometers have become the premier high resolution, broadband passive spectometer for laboratory and remote sensing applications. Following the four flights of the ATMOS instrument onboard the space shuttle, and with the development of emission sounders such as MIPAS (limb) and TES (nadir and limb), geostationary mesoscale sounders (GHIS), and polar meteorological sounders (IASI), the scientific role of FTS for remote sensing is indisputable. However, in general they remain less than ideal for space-based applications as a consequence of their size, mass, power, and telemetry requirements. A new concept for high resolution Fourier transform spectrometers suitable for space applications is described that reexamines each of the historical assumptions that have led to massive, large interferometers. The result will deliver the optical and radiometric performance of a high performance FTS such as ATMOS in a small (<0.25 m3), lightweight (20-25 kg) instrument with modest power requirements (<50 W), and with onboard data processing will have modest telemetry rates. Central to the concept is the realization that many of the historic assumptions about interferometer design are unnecessary, especially in a zero gravity environment.

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