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Academic literature on the topic 'Marmoset'

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Published: 4 June 2021
Last updated: 20 February 2023

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Journal articles on the topic "Marmoset"

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Correia-Caeiro, Catia, Anne Burrows, Duncan Andrew Wilson, Abdelhady Abdelrahman, and Takako Miyabe-Nishiwaki. "CalliFACS: The common marmoset Facial Action Coding System." PLOS ONE 17, no. 5 (May 17, 2022): e0266442. http://dx.doi.org/10.1371/journal.pone.0266442.

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Facial expressions are subtle cues, central for communication and conveying emotions in mammals. Traditionally, facial expressions have been classified as a whole (e.g. happy, angry, bared-teeth), due to automatic face processing in the human brain, i.e., humans categorise emotions globally, but are not aware of subtle or isolated cues such as an eyebrow raise. Moreover, the same facial configuration (e.g. lip corners pulled backwards exposing teeth) can convey widely different information depending on the species (e.g. humans: happiness; chimpanzees: fear). The Facial Action Coding System (FACS) is considered the gold standard for investigating human facial behaviour and avoids subjective interpretations of meaning by objectively measuring independent movements linked to facial muscles, called Action Units (AUs). Following a similar methodology, we developed the CalliFACS for the common marmoset. First, we determined the facial muscular plan of the common marmoset by examining dissections from the literature. Second, we recorded common marmosets in a variety of contexts (e.g. grooming, feeding, play, human interaction, veterinary procedures), and selected clips from online databases (e.g. YouTube) to identify their facial movements. Individual facial movements were classified according to appearance changes produced by the corresponding underlying musculature. A diverse repertoire of 33 facial movements was identified in the common marmoset (15 Action Units, 15 Action Descriptors and 3 Ear Action Descriptors). Although we observed a reduced range of facial movement when compared to the HumanFACS, the common marmoset’s range of facial movements was larger than predicted according to their socio-ecology and facial morphology, which indicates their importance for social interactions. CalliFACS is a scientific tool to measure facial movements, and thus, allows us to better understand the common marmoset’s expressions and communication. As common marmosets have become increasingly popular laboratory animal models, from neuroscience to cognition, CalliFACS can be used as an important tool to evaluate their welfare, particularly in captivity.
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Hori, Yuki, Justine C. Cléry, Janahan Selvanayagam, David J. Schaeffer, Kevin D. Johnston, Ravi S. Menon, and Stefan Everling. "Interspecies activation correlations reveal functional correspondences between marmoset and human brain areas." Proceedings of the National Academy of Sciences 118, no. 37 (September 7, 2021): e2110980118. http://dx.doi.org/10.1073/pnas.2110980118.

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The common marmoset has enormous promise as a nonhuman primate model of human brain functions. While resting-state functional MRI (fMRI) has provided evidence for a similar organization of marmoset and human cortices, the technique cannot be used to map the functional correspondences of brain regions between species. This limitation can be overcome by movie-driven fMRI (md-fMRI), which has become a popular tool for noninvasively mapping the neural patterns generated by rich and naturalistic stimulation. Here, we used md-fMRI in marmosets and humans to identify whole-brain functional correspondences between the two primate species. In particular, we describe functional correlates for the well-known human face, body, and scene patches in marmosets. We find that these networks have a similar organization in both species, suggesting a largely conserved organization of higher-order visual areas between New World marmoset monkeys and humans. However, while face patches in humans and marmosets were activated by marmoset faces, only human face patches responded to the faces of other animals. Together, the results demonstrate that higher-order visual processing might be a conserved feature between humans and New World marmoset monkeys but that small, potentially important functional differences exist.
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Zühlke, U., and G. Weinbauer. "The Common Marmoset (Callithrix jacchus) as a Model in Toxicology." Toxicologic Pathology 31, no. 1_suppl (January 2003): 123–27. http://dx.doi.org/10.1080/01926230390175002.

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The common marmoset, Callithrix jacchus, is the smallest nonhuman primate commonly used in biomedical research. Marmoset characteristics and propensities have enabled them to be used in a wide range of research as a model of human disease, physiology, drug metabolism, general toxicology, and reproductive biology. This paper provides a general overview of the marmoset with special emphasis on the benefits and disadvantages of this species as a model for inclusion in preclinical drug development programmes. In view of its small size in comparison with other nonrodent species marmosets have become of value for toxicology studies with biotechnology products where compound supply is limited. In general toxicology studies, marmosets have been successfully used to meet regulatory endpoints also for specific investigatory purposes. The widespread use of this species has allowed extensive background information to become available and a summary of the most frequently measured parameters are presented. Marmosets apparently represent an interesting animal model for comparative research on primate reproductive physiology. However, several basic aspects of reproductive processes exhibit cardinal discrepancies to those described for macaques and human. Thus, from the viewpoint of reproductive toxicology, the relevance of the marmoset primate model for human reproduction remains unclear to date and further research is obviously needed. Given our current knowledge of marmoset reproductive features, the use of this animal model cannot be recommended for reproductive toxicology assessment.
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Woller, Michael J., Pam L. Tannenbaum, Nancy J. Schultz-Darken, Bruce D. Eshelman, and David H. Abbott. "Pulsatile gonadotropin-releasing hormone release from hypothalamic explants of male marmoset monkeys compared with male rats." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 298, no. 1 (January 2010): R70—R78. http://dx.doi.org/10.1152/ajpregu.00193.2009.

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The present study was conducted to quantify in vitro gonadotropin-releasing hormone (GnRH) release parameters in the male marmoset. We established primary cultures of marmoset hypothalamic tissues for ∼2 days (marmosets) to assess GnRH release profiles in vitro in hypothalamic explants from testis-intact and gonadectomized males. Pulsatile GnRH release profiles were readily demonstrated from in vitro hypothalamic explants isolated from adult male marmoset monkeys. Gonadectomy of male marmosets resulted in elevated mean GnRH and pulse amplitude from hypothalamic explants on the 1st day of culture ( day 0). GnRH pulse amplitude increased by day 2 in ∼67% of hypothalamic explants from testis-intact marmosets, suggesting release from an endogenous regulator of GnRH. We also measured GnRH release profiles in vitro in hypothalamic explants from testis-intact and gonadectomized rats. Male rats showed no changes in any concentration or frequency release parameters for GnRH following gonadectomy or during successive days in culture. The present study represents a unique examination of GnRH release from male marmoset monkey hypothalamic tissue and compares release dynamics directly with those obtained from male rat, suggesting a species difference in feedback regulation of GnRH release.
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Schaeffer, David J., Ramina Adam, Kyle M. Gilbert, Joseph S. Gati, Alex X. Li, Ravi S. Menon, and Stefan Everling. "Diffusion-weighted tractography in the common marmoset monkey at 9.4T." Journal of Neurophysiology 118, no. 2 (August 1, 2017): 1344–54. http://dx.doi.org/10.1152/jn.00259.2017.

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Although significant progress has been made in mapping white matter connections in the marmoset brain using ex vivo tracing techniques, the application of in vivo virtual dissection of major white matter fiber tracts has been established by few studies in the marmoset literature. Here, we demonstrate the feasibility of whole-brain diffusion-weighted tractography in anesthetized marmosets at ultrahigh-field MRI (9.4T) and propose protocols for isolating nine major white matter fiber tracts in the marmoset brain.
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Cloherty, Shaun L., Jacob L. Yates, Dina Graf, Gregory C. DeAngelis, and Jude F. Mitchell. "Motion Perception in the Common Marmoset." Cerebral Cortex 30, no. 4 (December 11, 2019): 2659–73. http://dx.doi.org/10.1093/cercor/bhz267.

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Abstract Visual motion processing is a well-established model system for studying neural population codes in primates. The common marmoset, a small new world primate, offers unparalleled opportunities to probe these population codes in key motion processing areas, such as cortical areas MT and MST, because these areas are accessible for imaging and recording at the cortical surface. However, little is currently known about the perceptual abilities of the marmoset. Here, we introduce a paradigm for studying motion perception in the marmoset and compare their psychophysical performance with human observers. We trained two marmosets to perform a motion estimation task in which they provided an analog report of their perceived direction of motion with an eye movement to a ring that surrounded the motion stimulus. Marmosets and humans exhibited similar trade-offs in speed versus accuracy: errors were larger and reaction times were longer as the strength of the motion signal was reduced. Reverse correlation on the temporal fluctuations in motion direction revealed that both species exhibited short integration windows; however, marmosets had substantially less nondecision time than humans. Our results provide the first quantification of motion perception in the marmoset and demonstrate several advantages to using analog estimation tasks.
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Minton, Dennis M., Angela J. Marolf, Kelly S. Santangelo, Adam B. Salmon, and Adam R. Konopka. "DEVELOPING THE COMMON MARMOSET AS A TRANSLATIONAL MODEL OF AGE-RELATED OSTEOARTHRITIS." Innovation in Aging 3, Supplement_1 (November 2019): S104. http://dx.doi.org/10.1093/geroni/igz038.390.

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Abstract Age is a primary risk factor for osteoarthritis (OA). The mechanisms that contribute to OA are poorly understood and disease modifying treatments have not been identified. A critical shortcoming in developing therapies is the limited number of translational models available to identify the causes of naturally occurring OA. Our goal is to use the common marmoset as a non-human primate (NHP) model of age-related OA. NHP are the closest evolutionary relative to humans and share many characteristics of human aging. The marmoset has advantages over other NHP for aging research because of their relatively short maximal lifespan and small size. Micro-computed tomography (uCT) was performed on whole-knee joints obtained from young (10 yrs, n=3) marmosets at necropsy. OA was evaluated using a clinical uCT scoring system and quantitative assessments of subchondral bone structure and ossified meniscal volume. Advancing age was positively correlated to increased uCT OA score (p<0.05, r=0.59 ), mainly through increased number and size of osteophytes and progressive subchondral bone sclerosis from the medial to both medial and lateral compartments. For marmosets displaying meniscal ossification, older marmosets had greater (p<0.05) ossified meniscal volume than middle-aged and younger marmosets, respectively. Trabecular (p=0.05) and cortical bone thickness (p<0.05) were also lower in older marmosets. These data are the first to indicate that the marmoset develops naturally occurring, age-related OA and support the pursuit of additional studies using the marmoset to identify OA mechanisms and test potential interventions.
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Ma, Liya, Janahan Selvanayagam, Maryam Ghahremani, Lauren K. Hayrynen, Kevin D. Johnston, and Stefan Everling. "Single-unit activity in marmoset posterior parietal cortex in a gap saccade task." Journal of Neurophysiology 123, no. 3 (March 1, 2020): 896–911. http://dx.doi.org/10.1152/jn.00614.2019.

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Abnormal saccadic eye movements can serve as biomarkers for patients with several neuropsychiatric disorders. The common marmoset ( Callithrix jacchus) is becoming increasingly popular as a nonhuman primate model to investigate the cortical mechanisms of saccadic control. Recently, our group demonstrated that microstimulation in the posterior parietal cortex (PPC) of marmosets elicits contralateral saccades. Here we recorded single-unit activity in the PPC of the same two marmosets using chronic microelectrode arrays while the monkeys performed a saccadic task with gap trials (target onset lagged fixation point offset by 200 ms) interleaved with step trials (fixation point disappeared when the peripheral target appeared). Both marmosets showed a gap effect, shorter saccadic reaction times (SRTs) in gap vs. step trials. On average, stronger gap-period responses across the entire neuronal population preceded shorter SRTs on trials with contralateral targets although this correlation was stronger among the 15% “gap neurons,” which responded significantly during the gap. We also found 39% “target neurons” with significant saccadic target-related responses, which were stronger in gap trials and correlated with the SRTs better than the remaining neurons. Compared with saccades with relatively long SRTs, short-SRT saccades were preceded by both stronger gap-related and target-related responses in all PPC neurons, regardless of whether such response reached significance. Our findings suggest that the PPC in the marmoset contains an area that is involved in the modulation of saccadic preparation. NEW & NOTEWORTHY As a primate model in systems neuroscience, the marmoset is a great complement to the macaque monkey because of its unique advantages. To identify oculomotor networks in the marmoset, we recorded from the marmoset posterior parietal cortex during a saccadic task and found single-unit activities consistent with a role in saccadic modulation. This finding supports the marmoset as a valuable model for studying oculomotor control.
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Uehara, Shotaro, Toru Oshio, Kazuyuki Nakanishi, Etsuko Tomioka, Miyu Suzuki, Takashi Inoue, Yasuhiro Uno, Erika Sasaki, and Hiroshi Yamazaki. "Survey of Drug Oxidation Activities in Hepatic and Intestinal Microsomes of Individual Common Marmosets, a New Nonhuman Primate Animal Model." Current Drug Metabolism 20, no. 2 (April 30, 2019): 103–13. http://dx.doi.org/10.2174/1389200219666181003143312.

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Background: Common marmosets (Callithrix jacchus) are potentially useful nonhuman primate models for preclinical studies. Information for major drug-metabolizing cytochrome P450 (P450) enzymes is now available that supports the use of this primate species as an animal model for drug development. Here, we collect and provide an overview of information on the activities of common marmoset hepatic and intestinal microsomes with respect to 28 typical human P450 probe oxidations. Results: Marmoset P450 2D6/8-dependent R-metoprolol O-demethylation activities in hepatic microsomes were significantly correlated with those of midazolam 1′- and 4-hydroxylations, testosterone 6β-hydroxylation, and progesterone 6β-hydroxylation, which are probe reactions for marmoset P450 3A4/5/90. In marmosets, the oxidation activities of hepatic microsomes and intestinal microsomes were roughly comparable for midazolam and terfenadine. Overall, multiple forms of marmoset P450 enzymes in livers and intestines had generally similar substrate recognition functionalities to those of human and/or cynomolgus monkey P450 enzymes. Conclusion: The marmoset could be a model animal for humans with respect to the first-pass extraction of terfenadine and related substrates. These findings provide a foundation for understanding individual pharmacokinetic and toxicological results in nonhuman primates as preclinical models and will help to further support understanding of the molecular mechanisms of human P450 function.
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Wang, Xiaoqin, and Siddhartha C. Kadia. "Differential Representation of Species-Specific Primate Vocalizations in the Auditory Cortices of Marmoset and Cat." Journal of Neurophysiology 86, no. 5 (November 1, 2001): 2616–20. http://dx.doi.org/10.1152/jn.2001.86.5.2616.

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A number of studies in various species have demonstrated that natural vocalizations generally produce stronger neural responses than do their time-reversed versions. The majority of neurons in the primary auditory cortex (A1) of marmoset monkeys responds more strongly to natural marmoset vocalizations than to the time-reversed vocalizations. However, it was unclear whether such differences in neural responses were simply due to the difference between the acoustic structures of natural and time-reversed vocalizations or whether they also resulted from the difference in behavioral relevance of both types of the stimuli. To address this issue, we have compared neural responses to natural and time-reversed marmoset twitter calls in A1 of cats with those obtained from A1 of marmosets using identical stimuli. It was found that the preference for natural marmoset twitter calls demonstrated in marmoset A1 was absent in cat A1. While both cortices responded approximately equally to time-reversed twitter calls, marmoset A1 responded much more strongly to natural twitter calls than did cat A1. This differential representation of marmoset vocalizations in two cortices suggests that experience-dependent and possibly species-specific mechanisms are involved in cortical processing of communication sounds.
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Dissertations / Theses on the topic "Marmoset"

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Young, Fiona Margaret. "Luteal regression in the marmoset monkey." Thesis, University of Edinburgh, 2000. http://hdl.handle.net/1842/23277.

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Ovaries were studied on luteal days 10, 18 and 22 (corresponding to the mid luteal phase, functional luteal regression and structural luteal regression respectively), and also 12 and 24 hours after administration of either PGF2a or GnRH antagonist. Decreased progesterone concentrations indicative of functional luteal regression were apparent 12 hours later. Analysis of haematoxylin and eosin stained sections of corpora lutea indicated that the administration of PGF2a or GnRH antagonist resulted in apoptosis, and also in the formation of cytoplasmic vacuoles in steroidogenic cells. Apoptosis in corpora lutea was further investigated by 3' end labelling DNA extracted from corpora lutea, and by in situ 3' end labelling of sections of ovarian tissue. Apoptosis was found to occur after induced luteolysis and in naturally regressing corpora lutea but only after progesterone had decreased to follicular phase values. Therefore the decline in progesterone characteristic of functional luteal regression was not caused by the apoptotic cell death of steroidogenic cells. However, apoptosis played a role in structural luteal regression. Ubiquitin is expressed only by live cells undergoing a process of non-apoptotic cell death. Ubiquitin expression was only found in PGF2a, but not in GnRH antagonist treated luteal tissue, suggesting three possible explanations: that the cells in GnRH antagonist treated animals were dead prior to the collection point of 12 hours, or that the cells were not in a cell death pathway, or that cell death was occurring via different mechanisms in PGF2a and GnRH antagonist treated animals. The importance of the vasculature in luteal regression was investigated by labelling endothelial cells with an antibody against von Willebrand Factor VIII Antigen. Endothelial cell numbers remained constant after administration of luteolytic agents, indicating that induced luteal regression was not effected by vascular changes. Similarly, the vascualture did not change during functional regression in untreated animals. Vascular remodelling, however, occurred during structural luteal regression, when the vasculature changed from an extensive network of small capillaries to a system comprised of a lower number of larger blood vessels.
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Kühnel, Friederike. "Erhebung von Blutrichtwerten und deren Beeinflussung durch Haltung und Fütterung beim Weißbüschelaffen (Callithrix jacchus)." Doctoral thesis, Universitätsbibliothek Leipzig, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-129437.

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Weißbüschelaffen (WBA) sind wissenschaftlich häufig genutzte Modelltiere für diverse Humanerkrankungen. Zur Gesunderhaltung dieser Primaten sind grundlegende diagnostische Blutparameter unverzichtbar. Bisher erhobene Daten zeichneten sich jedoch durch große Divergenz aus. Ob Veränderungen in Haltungsbedingungen einen Einfluss auf diese Blutparameter nehmen, ist bis heute unklar. Somit war ein Ziel dieser Arbeit die Erhebung aktueller hämatologischer und klinisch-chemischer Blutparameter von WBA. Zudem wurde der Einfluss der routinemäßigen Umsetzung in eine neue Behausung auf die erhobenen Parameter sowie den Kortisolspiegel im Kot untersucht. Des Weiteren leiden WBA in menschlicher Obhut rezidivierend an gastrointestinalen Erkrankungen, die mittels klinischer Standardparameter allein nicht diagnostizierbar sind. Dabei spielt vor allem die Sensitivität gegenüber Futtermittelinhaltsstoffen (z. B. Gluten) eine Rolle, welche ursächlich im Zusammenhang mit dem Wasting Marmoset Syndrome (WMS) diskutiert wird. Im zweiten Teil der vorliegenden Arbeit sollten deshalb die gastrointestinalen Erkrankungen von in menschlicher Obhut lebenden WBA ätiologisch beleuchtet werden, vor allem hinsichtlich einer möglichen Sensitivität gegenüber Gluten. Im ersten Teil dieser Studie wurden von 54 WBA hämatologische und klinischchemische Richtwerte erhoben. Die ermittelten hämatologischen Blutrichtwerte ähneln denen aus den achtziger Jahren, die Daten der klinischen Chemie nur bedingt: Die Richtwertbereiche von Laktatdehydrogenase, Alaninaminotransferase, Lipase sowie Alkalische Phosphatase und Gesamtbilirubin weichen von den ehemals erhobenen Daten ab. Zudem wurden in der vorliegenden Arbeit geschlechtsabhängige Unterschiede ermittelt: Weibliche Tiere wiesen signifikant höheres mittleres Erythrozytenvolumen und mittleren Hämoglobingehalt des Einzelerythrozyten auf als männliche Tiere, wohingegen bei diesen ein signifikant höheres Gesamt- und Low density lipoprotein- Cholesterol im Vergleich zu weiblichen Affen messbar war. Des Weiteren wurden 16 Tiere über einen vierwöchigen Zeitraum in eine neue Umgebung verbracht, bevor sie in ihre Heimatbehausung zurückkehrten. Durch diese Umsetzung war bei den untersuchten Tieren die Leuko- und Lymphozytenzahl auch vier Wochen nach der Umsetzung erniedrigt. Zeitgleich lag ein erhöhter Kortisolspiegel vor, der im Kot bestimmt wurde. Im zweiten Teil der Studie wurden anhand humandiagnostischer Standards IgAAntikörper (AK) gegen Gliadin (AGA), Gewebstransglutaminase (tTG), deamidiertes Gliadin (ADGA) sowie Glykoprotein 2 (AGP2A) im Plasma von 24 WBA mittels eines ELISAs während glutenhaltiger (Diät 1) und glutenfreier Ernährung (Diät 2) bestimmt. Dabei wurden die klinische Symptomatik von WMS und das Körpergewicht der Tiere ebenfalls untersucht. Zudem erfolgte die Analyse von Kotproben antikörperpositiver Tiere hinsichtlich Qualität und Trockenmassegehalt während Diät 2 und einer darauf folgenden glutenhaltigen Provokationsdiät. Die serologische Diagnostik ergab einen signifikanten Rückgang von AGA, AK gegen tTG und AGP2A während Diät 2 bei Tieren, die nach Diät 1 erhöhte Werte aufwiesen. Diät 2 führte zu einem Rückgang der klinischen Symptome und einer signifikanten Gewichtszunahme bei antikörperpositiven WBA. Die glutenhaltige Provokationsdiät ergab eine verminderte Kotqualität mit einem niedrigeren Trockenmassegehalt. Es wurden im Rahmen dieser Arbeit aktuelle, hämatologische und klinisch-chemische Blutrichtwerte des WBA erhoben. Der durch Umsetzung in eine neue Behausung bedingte Stress ist bei WBA bis vier Wochen lang nachweisbar. Es ist sinnvoll, dies in der zeitlichen Planung wissenschaftlicher Studien zu berücksichtigen, um das Wohlbefinden der Tiere vor Versuchsbeginn sicherzustellen und den Einfluss von Stress auf experimentelle Ergebnisse zu minimieren. Der Nachweis grundlegender, an der Pathogenese der Zöliakie beteiligter Antikörper, in Kombination mit den klinischen Symptomen, deutet auf Glutensensitivität mit ätiologischer Beteiligung an WMS bei WBA hin. Die glutenfreie Ernährung von WBA in menschlicher Obhut ist daher sinnvoll und empfehlenswert
Common marmosets are often used as animal models for human diseases. For their health maintenance, diagnostic blood values are absolutely essential. Previously obtained reference values are characterized by great value-specific differences. Moreover, the influence of routine measures on these blood parameters, e. g. changes in housing conditions, has not been examined yet. Therefore, the first aim of the present study was to update haematological and clinical chemical blood parameters of common marmosets. Further, the influence of stress, caused by relocation to a new housing, on these parameters and the cortisol level in feces was examined. In addition to that, common marmosets under human management are often affected by gastrointestinal diseases, which are difficult to diagnose with basic standard blood values. In this context, sensitivity to nutritional elements, e. g. gluten, plays an important role and is discussed as a potential cause of wasting marmoset syndrome (WMS). In the second part of this study, the recurrent gastrointestinal diseases of common marmosets under human management were aetiologically investigated, with special regard to possible gluten sensitivity. In the first part of this study, blood samples were obtained from 54 female and male common marmosets to evaluate standard values of haematology and clinical chemistry. The determined haematological parameters are similar to the already obtained data, the clinical chemistry values differ somewhat: The enzyme activities of lactate dehydrogenase, alanine aminotransferase and lipase in addition to the ranges of alkaline phosphatase and total bilirubin diverge from the data ascertained in this study. Moreover, female animals presented significantly higher mean corpuscular volume and mean corpuscular haemoglobin than males, whereas male common marmosets showed significantly higher total- and low density lipoprotein-cholesterol, compared to females. Further, 16 animals were relocated to a new environment for a time period of four weeks, before they returned to their home cages. The change of housing caused a decreased leuko- and lymphocyte count in all examined animals that was still measurable four weeks after the relocation. At the same time, an increased fecal cortisol level was determined. The aim of the second study was to investigate the modification of plasma antibodies to gliadin (AGA), tissue transglutaminase (tTG), deamidated gliadin (ADGA) and glycoprotein 2 (AGP2A) during two successive diets in 24 animals: A gluten-containing diet (diet 1) and a gluten-free diet (diet 2). Further, clinical symptoms of WMS and the animals’ body weight were also examined. An analysis of the feces of antibody-positive animals regarding changes in quality and dry matter content was carried out with samples collected during diet 2 and a successive gluten challenge diet of two months duration. The serological diagnostics resulted in a significant decline of AGA, antibodies to tTG and AGP2A during diet 2 in animals that had shown increased antibody concentrations during diet 1. Diet 2 also caused an amelioration of clinical symptoms and an increased body weight in antibody-positive animals. The gluten challenge resulted in a decreased feces quality and a lower fecal dry matter, compared to fecal samples of diet 2. In the context of this dissertation, parameters of haematology and clinical chemistry of the common marmoset were updated. Stress caused by relocation to a new housing was still measurable for a period of four weeks. It is therefore essential to consider this time span in the design of scientific studies to secure animal welfare prior to the study and to reduce the influence of stress on experimental results. In combination with the clinical symptoms, the detection of antibodies that are part of the pathogenesis of coeliac disease in humans strongly suggests gluten sensitivity with an aetiological connection to WMS in common marmosets. Therefore, gluten-free nutrition of common marmosets under human management is highly recommendable
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Wagner, Wencke M. "Diagnostic imaging of the normal common marmoset (Callithrix jacchus)." Diss., University of Pretoria, 2004. http://upetd.up.ac.za/thesis/available/etd-06282005-111803/.

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Zöller, Martina. "Pathogenetische Untersuchungen zum Wasting-Marmoset-Syndrom bei Weissbüschelaffen (Callithrix jacchus)." Giessen DVG-Service, 2005. http://deposit.d-nb.de/cgi-bin/dokserv?idn=978259653.

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Dias, R. "Functional organisation of the prefrontal cortex of the common marmoset." Thesis, University of Cambridge, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.598525.

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In the past, two main theories of prefrontal function in animals have been proposed. The first implicates the prefrontal cortex in working memory, the second in the inhibitory control of behaviour. However, to date the organisation of the prefrontal cortex in the control of these functions is largely unknown. To address the issue of functional organisation within the prefrontal cortex of the marmoset, this thesis focused on the inhibitory control of behaviour. The initial study demonstrated that attentional set-shifting and visual discrimination reversal learning are sensitive to global prefrontal damage in the marmoset in a qualitatively similar manner to that observed previously in man and Old World monkeys respectively. The deficit was interpreted to be one of inhibitory control but, given the cognitive processing demands of these two tasks are different from one another, it is highly probable that the type of inhibitory control required is also different. Subsequently, the effects of discrete lesions specific to either the lateral or orbital regions of the prefrontal cortex on performance of attentional set-shifting and discrimination reversal learning were examined. Whereas the lateral, but not the orbital, prefrontal cortex was the critical locus in shifting an attentional set between perceptual dimensions; in contrast, the orbital, but not the lateral, prefrontal cortex was the critical locus in reversing a stimulus-reward association within a particular perceptual dimension. Both deficits were interpreted as constituting disinhibition or loss of inhibitory control, but a different levels. The inhibitory control required in attentional set-shifting appears to be at the level of attentional selection whereas the inhibitory control required in reversal learning is likely to be at the level of stimulus-reward associations or 'affective' processing.
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Dalrymple, Annette. "Prolactin receptor expression and signalling in the marmoset monkey uterus." Thesis, University of Edinburgh, 2001. http://hdl.handle.net/1842/23319.

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Immunohistochemical studies localised PRL expression to the stromal compartment of the marmoset endometrium. Expression was minimal during the proliferative phase and was up-regulated during the mid-late secretory phase of the ovulatory cycle. Similarly to PRL, PRL-R expression was minimal during the proliferative phase and was dramatically up-regulated during the mid-late secretory phase. However, expression of the PRL-r was localised to the glandular epithelium of the endometrium. The temporal pattern of PRL-R gene expression in the marmoset uterus across the ovulatory cycle was further confirmed by ribonuclease protection assay. The role of Jak2, Stat1 and Stat5 in the intracellular signalling pathway of PRL were also assessed in the mid-late secretory phase. Jak2/Stat1/Stat5 proteins were co-localised with the PRL-R to the glandular epithelial compartment. Moreover within the marmoset uterus, Jak2, Stat1 and Stat5 were temporarily phosphorylated in response to PRL. The pattern of expression of the IRF-1 gene, a PRL target gene, and the effect of PRL on transcription of IRF-1 were also investigated. IRF-1 expression in the marmoset uterus was encoded by a protein of 48 kDa and was localised to the glandular epithelial compartment, as was observed for the PRL-R and Jak2/Stat1/Stat5 proteins. Incubation of mid-late secretory uterine tissue with PRL for 3 hours resulted in 2.4 ± 0.5 (P<0.05) fold induction of IRF-1 gene expression. These studies confirm (a) high sequence and functional similarity between the marmoset and human PRL-R and (b) the expression of both PRL and its receptor in the uterus of the marmoset monkey. Expression of both genes is up-regulated during the mid-late secretory phase of the ovulatory cycle. PRL function in the marmoset uterus is linked to the Jak/Stat signalling pathway leading to the regulation of expression of PRL-responsive genes such as IRF-1. The site of expression of PRL, PRL-R and IRF-1 in the marmoset uterus suggest that PRL may influence glandular epithelial function and direct gene transcription in these cells in a paracrine fashion. In conclusion, the data strongly suggest that the marmoset monkey may provide a useful tool to investigate the role of PRL in human reproduction.
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Bogner, Katja. "Untersuchungen zur Lokalisation und Funktion von ZP-Proteinen im Marmoset-Modell." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=976072076.

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Cooke, Brian Roger. "The marmoset as a potential surrogate for human in drug development." Thesis, University of Surrey, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.521715.

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Seehase, Sophie [Verfasser]. "Marmoset monkeys as a preclinical model in respiratory research / Sophie Seehase." Hannover : Bibliothek der Tierärztlichen Hochschule Hannover, 2013. http://d-nb.info/1030452954/34.

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Davy, C. W. "Studies on some enzymes of diagnostic interest in the marmoset liver." Thesis, University of Hertfordshire, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.382216.

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Books on the topic "Marmoset"

1

The scampering marmoset. Aberdeen: Aberdeen University Press, 1990.

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Nunez, Sigrid. Mitz: The marmoset of Bloomsbury. New York: HarperFlamingo, 1998.

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Palazzi, Xavier, and Nicole Bordier. The Marmoset Brain in Stereotaxic Coordinates. New York, NY: Springer New York, 2008. http://dx.doi.org/10.1007/978-0-387-78385-7.

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M, Porter Leila, Davis Lesa C, and SpringerLink (Online service), eds. The Smallest Anthropoids: The Marmoset/Callimico Radiation. Boston, MA: Springer US, 2009.

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Lucie, Papineau, and Sarrazin Marisol 1965 ill, eds. Gilda the giraffe and Marvin the marmoset. Minneapolis, Minn: Picture Window Books, 2006.

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Pygmy marmosets. North Mankato, Minn: Capstone Press, 2013.

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Iriki, Atsushi, Hirotaka James Okano, Erika Sasaki, and Hideyuki Okano, eds. The 3-Dimensional Atlas of the Marmoset Brain. Tokyo: Springer Japan, 2018. http://dx.doi.org/10.1007/978-4-431-56612-0.

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Werneke, Mark. Callimico goeldii: 1988 international studbook = Internationales Zuchtbuch. Brookfield, Ill., U.S.A: Chicago Zoological Society, 1988.

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Rettberg, Beate. Callimico goeldii: 1983 international studbook = Internationales Zuchtbuch. Brookfield, Ill., U.S.A: Chicago Zoological Society, 1986.

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S, Ashwell Ken W., ed. Stereotaxic and chemoarchitectural atlas of the brain of the common marmoset. Boca Raton: Taylor & Francis, 2012.

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Book chapters on the topic "Marmoset"

1

Garber, Paul A., Alfred L. Rosenberger, and Marilyn A. Norconk. "Marmoset Misconceptions." In Adaptive Radiations of Neotropical Primates, 87–95. Boston, MA: Springer US, 1996. http://dx.doi.org/10.1007/978-1-4419-8770-9_5.

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Masuda-Suzukake, Masami, Aki Shimozawa, Masashi Hashimoto, and Masato Hasegawa. "Common Marmoset Model of." In Methods in Molecular Biology, 131–39. New York, NY: Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1495-2_13.

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Ford, Susan M., and Lesa C. Davis. "Marmoset Postcrania and the Skeleton of the Dwarf Marmoset, Callibella Humilis." In The Smallest Anthropoids, 411–48. Boston, MA: Springer US, 2009. http://dx.doi.org/10.1007/978-1-4419-0293-1_21.

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Kumar, Abhishek. "Integrating with Blender, Maya and Marmoset." In Beginning PBR Texturing, 165–86. Berkeley, CA: Apress, 2020. http://dx.doi.org/10.1007/978-1-4842-5899-6_16.

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Palazzi, Xavier, and Nicole Bordier. "The Marmoset Brain in Stereotaxic Coordinates." In The Marmoset Brain in Stereotaxic Coordinates, 1–59. New York, NY: Springer New York, 2008. http://dx.doi.org/10.1007/978-0-387-78385-7_1.

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Abbott, David H. "Reproduction in Female Marmoset Monkeys, Callithrix jacchus." In Reproductive Biology of South American Vertebrates, 245–61. New York, NY: Springer New York, 1992. http://dx.doi.org/10.1007/978-1-4612-2866-0_17.

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Annett, L. E., R. E. Smyly, J. M. Henderson, R. M. Cummings, A. L. Kendall, and S. B. Dunnett. "Behavioral Assessment in the Unilateral Dopamine-Depleted Marmoset." In Central Nervous System Diseases, 171–86. Totowa, NJ: Humana Press, 2000. http://dx.doi.org/10.1007/978-1-59259-691-1_10.

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Tardif, Suzette, Corinna Ross, and Darlene Smucny. "Building Marmoset Babies: Trade-Offs and Cutting Bait." In Building Babies, 169–83. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-4060-4_8.

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Yang, Guang, Hyenjong Hong, April Torres, Kristen E. Malloy, Gourav Roy-Choudhury, Jeffrey Kim, and Marcel M. Daadi. "Reference Transcriptome for Deriving Marmoset Induced Pluripotent Stem Cells." In Methods in Molecular Biology, 175–86. New York, NY: Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9007-8_13.

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Verhagen, Svenja, and Almuth Einspanier. "Relaxin: a luteotrophic factor in the marmoset corpus luteum." In Relaxin 2000, 139–44. Dordrecht: Springer Netherlands, 2001. http://dx.doi.org/10.1007/978-94-017-2877-5_18.

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Conference papers on the topic "Marmoset"

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Weitz, J., S. Landman, and S. Birken. "IDENTIFICATION OF A NEUTROPHIL ELASTASE CLEAVAGE SITE ON THE Act -CHAIN OF PRIMATE FIBRINOGEN." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643896.

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Human neutrophil elastase (HNE) cleaves the Aα21-22 bond of fibrinogen thus releasing the fibrinopeptide A (FPA)-containing fragment Aαl-21. Plasma Aal-21 levels reflect in vivo HNE activity and peptide levels are increased in cigarette smokers and patients with chronic lung disease. To further explore the HNE-fibrinogen interaction, we set out to develop an animal model. The digestion of purified baboon and marmoset fibrinogen by human thrombin, HNE and extracts of baboon and marmoset neutrophils was monitored with a specific radioimmunoassay for human FPA. Thrcmbin produced quantitative release (2 mol/mol fibrinogen) of FPA. In contrast, HNE and the neutrophil extracts did not release FPA, but rather, produced quantitative release of a larger, FPA-containing fragment. Immunochemically, this fragment was clearly distinguishable from FPA in that in vitro thrombin treatment increased its immunoreactivity 1,000-fold (thrombin increasable FPA or TIFPA). TIFPA release by the neutrophil extracts was blocked by α1-proteinase inhibitor, a specific HNE inhibitor (MeO-Suc-Ala2-Pro-ValCH2Cl) and an anti-HNE IgG, indicating that elastase was the responsible proteinase and that there was homology between the human and primate enzymes. The products of HNE and neutrophil extract proteolysis of the primate fibrinogens were then separated by high performance liquid chromatography and the TIFPA-containing fractions were subjected to amino acid sequence analysis. The FPA-containing fragments each consisted of 21 amino acids, had minor substitutions when compared with human A α] -21 [Baboon: Aα(3) Ser - Thr; Marmoset Aα(l) Ala - Thr, Aα(3) Ser - Thr, Aα(ll) Glu - Ala], and exhibited complete crossreactivity with the human peptide. Using the TIFPA assay, there was good recovery of primate or human Aαl-21 added to primate blood and the mean peptide level in 8 healthy marmosets was similar to that in man (0.5 nM and 0.4 nM, respectively). In conclusion, (1) the Aα;21 -22 bond of baboon and marmoset fibrinogen is a cleavage site for human and primate elastase, (2) baboon and marmoset Aal-21 can be measured with the assay for the human peptide, and (3) the primate serves as a useful model for the study of elastase-fibrinogen interactions.
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Spacco, Jaime, David Hovemeyer, William Pugh, Fawzi Emad, Jeffrey K. Hollingsworth, and Nelson Padua-Perez. "Experiences with marmoset." In the 11th annual SIGCSE conference. New York, New York, USA: ACM Press, 2006. http://dx.doi.org/10.1145/1140124.1140131.

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Spacco, Jaime, William Pugh, Nat Ayewah, and David Hovemeyer. "The Marmoset project." In Companion to the 21st ACM SIGPLAN conference. New York, New York, USA: ACM Press, 2006. http://dx.doi.org/10.1145/1176617.1176665.

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Verma, Sakshi, K. L. Prateek, Karthik Pandia, Nauman Dawalatabad, Rogier Landman, Jitendra Sharma, Mriganka Sur, and Hema A. Murthy. "Discovering Language in Marmoset Vocalization." In Interspeech 2017. ISCA: ISCA, 2017. http://dx.doi.org/10.21437/interspeech.2017-842.

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Spacco, Jaime, Jaymie Strecker, David Hovemeyer, and William Pugh. "Software repository mining with Marmoset." In the 2005 international workshop. New York, New York, USA: ACM Press, 2005. http://dx.doi.org/10.1145/1083142.1083149.

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Veale, Richard, Chih-yang Chen, and Tadashi Isa. "Marmoset Monkeys Model Human Infant Gaze?" In 2021 IEEE International Conference on Development and Learning (ICDL). IEEE, 2021. http://dx.doi.org/10.1109/icdl49984.2021.9515602.

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Wisler, Alan, Laura J. Brattain, Rogier Landman, and Thomas F. Quatieri. "A Framework for Automated Marmoset Vocalization Detection and Classification." In Interspeech 2016. ISCA, 2016. http://dx.doi.org/10.21437/interspeech.2016-1410.

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Brattain, Laura J., Rogier Landman, Kerry A. Johnson, Patrick Chwalek, Julia Hyman, Jitendra Sharma, Charles Jennings, Robert Desimone, Guoping Feng, and Thomas F. Quatieri. "A multimodal sensor system for automated marmoset behavioral analysis." In 2016 IEEE 13th International Conference on Wearable and Implantable Body Sensor Networks (BSN). IEEE, 2016. http://dx.doi.org/10.1109/bsn.2016.7516269.

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Mescam, M., J. Brossard, N. Vayssiere, and C. Fonta. "Multi-angle TOF MR brain angiography of the common marmoset." In 2017 IEEE 14th International Symposium on Biomedical Imaging (ISBI 2017). IEEE, 2017. http://dx.doi.org/10.1109/isbi.2017.7950714.

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KATO, MASAKI, KAZUO OKANOYA, TAKU KOIKE, SHIGERU WATANABE, and ATSUSHI IRIKI. "EXPRESSION ANALYSIS OF LANGUAGE-RELATED GENES IN THE COMMON MARMOSET BRAIN." In Proceedings of the 9th International Conference (EVOLANG9). WORLD SCIENTIFIC, 2012. http://dx.doi.org/10.1142/9789814401500_0086.

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Reports on the topic "Marmoset"

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Arkani-Hamed, Nima, Philip Schuster, Natalia Toro, Jesse Thaler, Lian-Tao Wang, Bruce Knuteson, and Stephen Mrenna. MARMOSET: The Path from LHC Data to the New Standard Model via On-Shell Effective Theories. Office of Scientific and Technical Information (OSTI), March 2007. http://dx.doi.org/10.2172/902546.

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Cecile, M. P. Geology, Marmot Creek, Yukon Territory. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 1998. http://dx.doi.org/10.4095/209701.

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Zhang, Yongfeng, Daniel Schwen, Pritam Chakraborty, Chao Jiang, Larry Aagesen, Karim Ahmed, Wen Jiang, et al. MARMOT update for oxide fuel modeling. Office of Scientific and Technical Information (OSTI), September 2016. http://dx.doi.org/10.2172/1364504.

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Fromm, B., Y. Zhang, D. Schwen, D. Brown, and R. Pokharel. Assessment of MARMOT Grain Growth Model. Office of Scientific and Technical Information (OSTI), December 2015. http://dx.doi.org/10.2172/1261063.

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Lance, Ellen Weintraub. Montague Island marmot: a conservation assessment. Portland, OR: U.S. Department of Agriculture, Forest Service, Pacific Northwest Research Station, 2002. http://dx.doi.org/10.2737/pnw-gtr-541.

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Barker, Erin I., Dongsheng Li, Hussein M. Zbib, and Xin Sun. Gradient Plasticity Model and its Implementation into MARMOT. Office of Scientific and Technical Information (OSTI), August 2013. http://dx.doi.org/10.2172/1133998.

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Tonks, M. R., D. Schwen, Y. Zhang, P. Chakraborty, X. Bai, B. Fromm, J. Yu, M. C. Teague, and D. A. Andersson. Assessment of MARMOT. A Mesoscale Fuel Performance Code. Office of Scientific and Technical Information (OSTI), April 2015. http://dx.doi.org/10.2172/1196556.

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Aaron S. Butterfield. EXPLORATION OF THE PHASE FIELD FRAMEWORK MARMOT TO. Office of Scientific and Technical Information (OSTI), July 2013. http://dx.doi.org/10.2172/1093887.

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Zhang, Yongfeng, Daniel Schwen, Larry K. Aagesen, Jr., Benjamin W. Beeler, Chao Jiang, Yipeng Gao, Michael Tonks, and Xianming Bai. FY17 end of year MARMOT materials model development update. Office of Scientific and Technical Information (OSTI), October 2017. http://dx.doi.org/10.2172/1473591.

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Schwen, Daniel, P. Chakraborty, M. R. Tonks, B. Fromm, Yongfeng Zhang, Xianming Bai, and D. A. Andersson. Release 1.0 of MARMOT: A Mesoscale Fuel Performance Code. Office of Scientific and Technical Information (OSTI), September 2015. http://dx.doi.org/10.2172/1482992.

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