Journal articles: 'Marine metabolites'

1

Pirog, T. P. "PRACTICALLY VALUABLE METABOLITES OF MARINE MICROORGANISMS." Biotechnologia Acta 13, no. 3 (June 2020): 5–29. http://dx.doi.org/10.15407/biotech13.03.005.

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Uras, İbrahim Seyda, and Belma Konuklugil. "Anticancer secondary metabolites from marine sponges." Ege Journal of Fisheries and Aquatic Sciences 38, no. 1 (March 15, 2021): 101–6. http://dx.doi.org/10.12714/egejfas.38.1.12.

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The oceans cover 70% of the Earth’s surface. The marine environment is an important source of secondary metabolites with high biodiversity. Besides other marine species, sponges with a wide range of secondary metabolites are an important potential for drug discovery. Cancer is one of the leading causes of death with high morbidity and mortality. It is very important to discover new therapeutic agents in the treatment of cancer. In recent years, studies on exploring new anticancer compounds are focused on the marine source. In this review, our target is collecting the studies about marine sponges secondary metabolites which have an anticancer effect. Among most of the isolated compounds from sponges and their semisynthetic derivatives, there are three FDA (US Food and Drug Administration) approved compounds and three compounds in clinical phase. Moreover, more than 40 compounds isolated from marine sponges have been tested for anticancer activity in recent 10 years. In conclusion marine sponges secondary metabolites are a promising and important source of the anticancer compounds.

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Blunden, Gerald. "Metabolites from marine algae." Progress in Oceanography 21, no. 2 (January 1988): 217–26. http://dx.doi.org/10.1016/0079-6611(88)90041-9.

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Fenizia, Simona, Jerrit Weissflog, and Georg Pohnert. "Cysteinolic Acid Is a Widely Distributed Compatible Solute of Marine Microalgae." Marine Drugs 19, no. 12 (November 30, 2021): 683. http://dx.doi.org/10.3390/md19120683.

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Phytoplankton rely on bioactive zwitterionic and highly polar small metabolites with osmoregulatory properties to compensate changes in the salinity of the surrounding seawater. Dimethylsulfoniopropionate (DMSP) is a main representative of this class of metabolites. Salinity-dependent DMSP biosynthesis and turnover contribute significantly to the global sulfur cycle. Using advanced chromatographic and mass spectrometric techniques that enable the detection of highly polar metabolites, we identified cysteinolic acid as an additional widely distributed polar metabolite in phytoplankton. Cysteinolic acid belongs to the class of marine sulfonates, metabolites that are commonly produced by algae and consumed by bacteria. It was detected in all dinoflagellates, haptophytes, diatoms and prymnesiophytes that were surveyed. We quantified the metabolite in different phytoplankton taxa and revealed that the cellular content can reach even higher concentrations than the ubiquitous DMSP. The cysteinolic acid concentration in the cells of the diatom Thalassiosira weissflogii increases significantly when grown in a medium with elevated salinity. In contrast to the compatible solute ectoine, cysteinolic acid is also found in high concentrations in axenic algae, indicating biosynthesis by the algae and not the associated bacteria. Therefore, we add this metabolite to the family of highly polar metabolites with osmoregulatory characteristics produced by phytoplankton.

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Sedaca, Albetina. "Urgency and Mechanism of Biosynthesis of Marine Microbial Secondary Metabolites." International Journal of Science and Society 2, no. 4 (September 11, 2020): 159–66. http://dx.doi.org/10.54783/ijsoc.v2i4.201.

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Marine microorganism is one of biologically active potential resources of secondary metabolites. Its potency are so promising that the knowledge of how its secondary metabolite occured need to be studied and collected. Those knowledges will enable further study is improving secondary metabolite production in the laboratory. In nature, secondary metabolites synthesis occur when there are effect of both biotic and abiotic factors such as sea water and microbe symbiosis with other living materials. When this is explained in metabolic pathways, secondary metabolite synthesis affected by available nutrient and regulated by autoinducer molecules through quorum sensing mechanism.

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Edward Amado. "Urgency and Mechanism of Biosynthesis of Marine Microbial Secondary Metabolites." INFLUENCE : International Journal of Science Review 3, no. 3 (November 29, 2021): 229–34. http://dx.doi.org/10.54783/influence.v3i3.181.

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Marine microorganism is one of biologically active potential resources of secondary metabolites. Its potency are so promising that the knowledge of how its secondary metabolite occured need to be studied and collected. Those knowledges will enable further study is improving secondary metabolite production in the laboratory. In nature, secondary metabolites synthesis occur when there are effect of both biotic and abiotic factors such as sea water and microbe symbiosis with other living materials. When this is explained in metabolic pathways, secondary metabolite synthesis affected by available nutrient and regulated by autoinducer molecules through quorum sensing mechanism

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7

Andryukov, Boris, Valery Mikhailov, and Nataly Besednova. "The Biotechnological Potential of Secondary Metabolites from Marine Bacteria." Journal of Marine Science and Engineering 7, no. 6 (June 3, 2019): 176. http://dx.doi.org/10.3390/jmse7060176.

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Marine habitats are a rich source of molecules of biological interest. In particular, marine bacteria attract attention with their ability to synthesize structurally diverse classes of bioactive secondary metabolites with high biotechnological potential. The last decades were marked by numerous discoveries of biomolecules of bacterial symbionts, which have long been considered metabolites of marine animals. Many compounds isolated from marine bacteria are unique in their structure and biological activity. Their study has made a significant contribution to the discovery and production of new natural antimicrobial agents. Identifying the mechanisms and potential of this type of metabolite production in marine bacteria has become one of the noteworthy trends in modern biotechnology. This path has become not only one of the most promising approaches to the development of new antibiotics, but also a potential target for controlling the viability of pathogenic bacteria.

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Kijjoa, Anake, Rawiwan Watanadilok, Pichai Sonchaeng, Pichan Sawangwong, Madalena Pedro, Maria São José Nascimento, Artur M. S. Silva, Graham Eaton, and Werner Herz. "Further Halotyrosine Derivatives from the Marine Sponge Suberea aff. praetensa." Zeitschrift für Naturforschung C 57, no. 7-8 (August 1, 2002): 732–38. http://dx.doi.org/10.1515/znc-2002-7-831.

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Reexamination of the marine sponge Suberea aff. praetensa, (Row) from the Gulf of Thailand furnished in addition to bromotyrosine derivatives found previously 5-bromo- and 5- chlorocavernicolin, cavernicolins 1 and 2, two other brominated tyrosine metabolites, a known bisoxazolidone and a new unusual rearranged tyrosine metabolite subereatensin. Several of the metabolites exhibited significant inhibitory effects against five human cancer cell lines.

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Handley, Jackie T., and Adrian J. Blackman. "Secondary Metabolites from the Marine Alga Caulerpa brownii (Chlorophyta)." Australian Journal of Chemistry 58, no. 1 (2005): 39. http://dx.doi.org/10.1071/ch04174.

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The green seaweed Caulerpa brownii (Chlorophyta, Caulerpaceae) occurs in Tasmania in two morphological forms (branched and unbranched) and each form has a different profile of diterpenoid secondary metabolites. Unbranched specimens gave rise to the novel secondary metabolites 11, 13, 14, 17, and 18, the secondary metabolite 8 that has been isolated for the first time as a natural product, as well as the known compounds 1 and 3–7. Branched specimens of C. brownii yielded the novel terpenoid esters 21 and the known compounds 1 and 2.

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10

Li, Hong-yu, Shigeki Matsunaga, and Nobuhiro Fusetani. "Antifungal Metabolites from Marine Sponges." Current Organic Chemistry 2, no. 6 (November 1998): 649–82. http://dx.doi.org/10.2174/1385272802666220130083412.

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Ease in collecting relatively large amounts of diverse species together with a high incidence of active samples has made marine sponges a good source of antifungal compounds. Although classical antimicrobial screening is now replaced by more disease-oriented sophisticated screening, many antifungal compounds with a wide structural diversity have been reported from marine sponges in the long history of the search for these compounds. In this review we describe antifungal compounds isolated from marine sponges since 1987 according to their structural types.

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11

KELECOM, ALPHONSE. "Secondary metabolites from marine microorganisms." Anais da Academia Brasileira de Ciências 74, no. 1 (March 2002): 151–70. http://dx.doi.org/10.1590/s0001-37652002000100012.

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After 40 years of intensive research, chemistry of marine natural products has become a mature field. Since 1995, there are signals of decreased interest in the search of new metabolites from traditional sources such as macroalgae and octocorals, and the number of annual reports on marine sponges stabilized. On the contrary, metabolites from microorganisms is a rapidly growing field, due, at least in part, to the suspicion that a number of metabolites obtained from algae and invertebrates may be produced by associated microorganisms. Studies are concerned with bacteria and fungi, isolated from seawater, sediments, algae, fish and mainly from marine invertebrates such as sponges, mollusks, tunicates, coelenterates and crustaceans. Although it is still to early to define tendencies, it may be stated that the metabolites from microorganisms are in most cases quite different from those produced by the invertebrate hosts. Nitrogenated metabolites predominate over acetate derivatives, and terpenes are uncommon. Among the latter, sesquiterpenes, diterpenes and carotenes have been isolated; among nitrogenated metabolites, amides, cyclic peptides and indole alkaloids predominate.

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12

Habbu, Prasanna, Vijayanand Warad, Rajesh Shastri, Smita Madagundi, and Venkatrao H. Kulkarni. "Antimicrobial metabolites from marine microorganisms." Chinese Journal of Natural Medicines 14, no. 2 (February 2016): 101–16. http://dx.doi.org/10.1016/s1875-5364(16)60003-1.

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13

Guyot, Michèle. "Bioactive metabolites from marine invertebrates." Pure and Applied Chemistry 66, no. 10-11 (January 1, 1994): 2223–26. http://dx.doi.org/10.1351/pac199466102223.

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14

Daletos, Georgios, Elena Ancheeva, Chaidir Chaidir, Rainer Kalscheuer, and Peter Proksch. "Antimycobacterial Metabolites from Marine Invertebrates." Archiv der Pharmazie 349, no. 10 (August 26, 2016): 763–73. http://dx.doi.org/10.1002/ardp.201600128.

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15

Fusetani, Nobuhiro, Takeo Sugawara, Shigeki Matsunaga, and Hiroshi Hirota. "Bioactive marine metabolites. Part 35. Cytotoxic metabolites of the marine sponge Mycale adhaerens Lambe." Journal of Organic Chemistry 56, no. 16 (August 1991): 4971–74. http://dx.doi.org/10.1021/jo00016a031.

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16

Buatong, Jirayu, Vatcharin Rukachaisirikul, Suthinee Sangkanu, Frank Surup, and Souwalak Phongpaichit. "Antifungal Metabolites from Marine-Derived Streptomyces sp. AMA49 against Pyricularia oryzae." Journal of Pure and Applied Microbiology 13, no. 2 (June 30, 2019): 653–65. http://dx.doi.org/10.22207/jpam.13.2.02.

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17

Liu, Yuanwei, Kishneth Palaniveloo, Siti Aisyah Alias, and Jaya Seelan Sathiya Seelan. "Species Diversity and Secondary Metabolites of Sarcophyton-Associated Marine Fungi." Molecules 26, no. 11 (May 27, 2021): 3227. http://dx.doi.org/10.3390/molecules26113227.

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Soft corals are widely distributed across the globe, especially in the Indo-Pacific region, with Sarcophyton being one of the most abundant genera. To date, there have been 50 species of identified Sarcophyton. These soft corals host a diverse range of marine fungi, which produce chemically diverse, bioactive secondary metabolites as part of their symbiotic nature with the soft coral hosts. The most prolific groups of compounds are terpenoids and indole alkaloids. Annually, there are more bio-active compounds being isolated and characterised. Thus, the importance of the metabolite compilation is very much important for future reference. This paper compiles the diversity of Sarcophyton species and metabolites produced by their associated marine fungi, as well as the bioactivity of these identified compounds. A total of 88 metabolites of structural diversity are highlighted, indicating the huge potential these symbiotic relationships hold for future research.

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18

Schneemann, Imke, Kerstin Nagel, Inga Kajahn, Antje Labes, Jutta Wiese, and Johannes F. Imhoff. "Comprehensive Investigation of Marine Actinobacteria Associated with the Sponge Halichondria panicea." Applied and Environmental Microbiology 76, no. 11 (April 9, 2010): 3702–14. http://dx.doi.org/10.1128/aem.00780-10.

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ABSTRACT Representatives of Actinobacteria were isolated from the marine sponge Halichondria panicea collected from the Baltic Sea (Germany). For the first time, a comprehensive investigation was performed with regard to phylogenetic strain identification, secondary metabolite profiling, bioactivity determination, and genetic exploration of biosynthetic genes, especially concerning the relationships of the abundance of biosynthesis gene fragments to the number and diversity of produced secondary metabolites. All strains were phylogenetically identified by 16S rRNA gene sequence analyses and were found to belong to the genera Actinoalloteichus, Micrococcus, Micromonospora, Nocardiopsis, and Streptomyces. Secondary metabolite profiles of 46 actinobacterial strains were evaluated, 122 different substances were identified, and 88 so far unidentified compounds were detected. The extracts from most of the cultures showed biological activities. In addition, the presence of biosynthesis genes encoding polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) in 30 strains was established. It was shown that strains in which either PKS or NRPS genes were identified produced a significantly higher number of metabolites and exhibited a larger number of unidentified, possibly new metabolites than other strains. Therefore, the presence of PKS and NRPS genes is a good indicator for the selection of strains to isolate new natural products.

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19

Raisa, Sheila, Astika Widy Utomo, Rebriarina Hapsari, and Endang Mahati. "IDENTIFICATION OF SECONDARY METABOLITE COMPOUNDS IN TUNICATE (Polycarpa aurata) ASSOCIATED BACTERIA." DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) 10, no. 6 (November 30, 2021): 401–6. http://dx.doi.org/10.14710/dmj.v10i6.30103.

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Background: Marine biodiversity in the last few decades has been explored and utilized as marine natural products. The secondary metabolites produced by marine organisms are utilized by humans in various aspects of life. One of the main source of secondary metabolites is marine invertebrates, such as tunicate. Several previous studies have shown that many metabolites have been identified in the last 40 years.Objective: This study aimed to identify the metabolite compounds produced by tunicate-associated bacteria.Methods: The two isolates of bacteria associated with tunicate Polycarpa aurata, Bacillus wiedmannii and Virgibacillus salarius, obtained from the culture collection of Tropical Marine Biotechnology laboratory, Faculty of Fisheries and Marine Sciences, Diponegoro University, Semarang were used as material in this study. This study was carried out in Integrated Laboratory Diponegoro University from July to September 2020. Laboratory experiment was conducted by culturing these bacteria in Zobell Marine Broth 2216 at room temperature. The incubated culture was then added with ethyl acetate in a ratio of 1: 2 and then the supernatant was separated and evaporated. Analysis of the tunicate-associated bacteria methanol extract was carried out using Gas Chromatography-Mass Spectrophotometry (GC-MS).Results: 3-N-Hexyl-Delta-9-Tetrahydrocannabinol compound (100%) was discovered by GC-MS analysis from the tunicate-associated bacteria B. wiedmannii and V. salarius extract.Conclusion: 3-N-Hexyl-Delta-9-Tetrahydrocannabinol compound is an isomer compound of Delta-9-Tetrahydrocannabinol (Δ9-THC) which needs further research on its application in medical and non-medical aspects.

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20

K., Sathiyamurthy, and Bavithra H. "Bioactive potential of Pseudomonas alcaliphila isolated from a marine sponge against human pathogens." International Journal of Bio-Pharma Research 8, no. 3 (March 3, 2019): 2494–22503. http://dx.doi.org/10.21746/ijbpr.2019.8.3.2.

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Metabolite extraction is considered as one of the important steps in metabolomics, the marine metabolite are the new source of the most antimicrobial agents used in both pharmacological and biological applications. In the present study, sponge associated bacterial metabolites was investigated. A total of 20 bacterial strains were isolated from the sponge Haliclona sp., All the strains were screened primarily with cross streaking method against human bacterial pathogens. The potent isolate was chosen based on the good inhibitory activity and metabolite extraction was achieved using chloroform: methanol mixture. The metabolites were then checked for their antimicrobial activity by disk diffusion and also minimum inhibitory concentration was determined. Out of 20 bacterial strains, only one strain selected based on the good inhibitory activity against pathogens and the strain was identified as Pseudomonas alcaliphila based on the biochemical and16S rRNA sequencing. The results revealed that the metabolites exhibited high activity and it was found that Klebsiella pneumoniae was inhibited high with the diameter of 22 mm followed by Salmonella Typhi (15 mm), E.coli (12 mm), and Bacillus subtilis (15 mm). The MIC was observed at 31.25 µg/ml against all pathogens. Results of TLC exhibited the Rf value at 0.86 and the FTIR results revealed the presence of C=o, amide bond, amino acids and methoxy groups. In GC-MS results showed that the metabolites mostly contain fatty acids and alkenes compounds. Thus, this marine active compound was considered as a novel compound for biological applications and may be a potential drug for therapeutic use.

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21

Radjasa, Ocky Karna, and Agus Sabdono. "MOLECULAR DIVERSITY OF SECONDARY METABOLITE-PRODUCING MARINE MICROORGANISMS ASSOCIATED WITH INDONESIAN REEF'S INVERTEBRATES." Marine Research in Indonesia 33, no. 2 (December 31, 2008): 121–28. http://dx.doi.org/10.14203/mri.v33i2.485.

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The metabolites from microorganisms are a rapidly growing field, due to the suspicion that a number of metabolites obtained from reef's invertebrates are produced by associated microorganisms. Less than 2% of microbial flora has been successfully isolated from marine environment. Coral reefs are the most diverse marine ecosystems, however, little is known about the microbial diversity in these ecosystems. It is expected that still quite a few parts of unexplored culturable invertebrate-associated microorganisms exists in the reef environments. The present study aimed at estimating the biodiversity of secondary metabolite-producing microbes associated with reef's invertebrates such as coral, soft coral and sponge collected from geographically different areas.

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22

Longnecker, Krista, and Elizabeth B. Kujawinski. "Intracellular Metabolites in Marine Microorganisms during an Experiment Evaluating Microbial Mortality." Metabolites 10, no. 3 (March 12, 2020): 105. http://dx.doi.org/10.3390/metabo10030105.

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Metabolomics is a tool with immense potential for providing insight into the impact of biological processes on the environment. Here, we used metabolomics methods to characterize intracellular metabolites within marine microorganisms during a manipulation experiment that was designed to test the impact of two sources of microbial mortality, protozoan grazing and viral lysis. Intracellular metabolites were analyzed with targeted and untargeted mass spectrometry methods. The treatment with reduced viral mortality showed the largest changes in metabolite concentrations, although there were organic compounds that shifted when the impact of protozoan grazers was reduced. Intracellular concentrations of guanine, phenylalanine, glutamic acid, and ectoine presented significant responses to changes in the source of mortality. Unexpectedly, variability in metabolite concentrations were not accompanied by increases in microbial abundance which indicates that marine microorganisms altered their internal organic carbon stores without changes in biomass or microbial growth. We used Weighted Correlation Network Analysis (WGCNA) to identify correlations between the targeted and untargeted mass spectrometry data. This analysis revealed multiple unknown organic compounds were correlated with compatible solutes, also called osmolytes or chemical chaperones, which emphasizes the dominant role of compatible solutes in marine microorganisms.

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23

Ancheeva, Elena, Mona El-Neketi, Weiguo Song, Wenhan Lin, Georgios Daletos, Weaam Ebrahim, and Peter Proksch. "Structurally Unprecedented Metabolites from Marine Sponges." Current Organic Chemistry 21, no. 5 (January 10, 2017): 426–49. http://dx.doi.org/10.2174/1385272820666161017164957.

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24

Kita, Masaki, Emi Sakai, and Daisuke Uemura. "Pursuit of Novel Bioactive Marine Metabolites." Journal of Synthetic Organic Chemistry, Japan 64, no. 5 (2006): 471–80. http://dx.doi.org/10.5059/yukigoseikyokaishi.64.471.

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25

KONUKLUGİL, Belma. "Secondary Metabolites from Marine Sources: Review." Turkiye Klinikleri Journal of Pharmacy Sciences 5, no. 2 (2016): 110–17. http://dx.doi.org/10.5336/pharmsci.2016-50608.

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26

Comba, Peter, Nina Dovalil, Lawrence R. Gahan, Graeme R. Hanson, and Michael Westphal. "Cyclic peptide marine metabolites and CuII." Dalton Trans. 43, no. 5 (2014): 1935–56. http://dx.doi.org/10.1039/c3dt52664j.

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27

Chen, Gang, Hai-Feng Wang, and Yue-Hu Pei. "Secondary metabolites from marine-derived microorganisms." Journal of Asian Natural Products Research 16, no. 1 (November 11, 2013): 105–22. http://dx.doi.org/10.1080/10286020.2013.855202.

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28

Kobayashi, Junichi, and Masami Ishibashi. "Bioactive metabolites of symbiotic marine microorganisms." Chemical Reviews 93, no. 5 (July 1993): 1753–69. http://dx.doi.org/10.1021/cr00021a005.

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29

Sobolevskaya, M. P., and T. A. Kuznetsova. "Biologically active metabolites of marine actinobacteria." Russian Journal of Bioorganic Chemistry 36, no. 5 (September 2010): 560–73. http://dx.doi.org/10.1134/s1068162010050031.

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30

Keyzers, Robert A., and Michael T. Davies-Coleman. "Anti-inflammatory metabolites from marine sponges." Chemical Society Reviews 34, no. 4 (2005): 355. http://dx.doi.org/10.1039/b408600g.

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31

König, G., A. Wright, R. de Nys, and O. Sticher. "New Terpenoid Metabolites from Marine Algae." Planta Medica 56, no. 06 (December 1990): 559–60. http://dx.doi.org/10.1055/s-2006-961144.

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32

Su, Jingyu, Longmei Zeng, Yongli Zhong, and Xiong Fu. "Biologically Active Metabolites from Marine Organisms." Journal of the Chinese Chemical Society 42, no. 4 (August 1995): 735–38. http://dx.doi.org/10.1002/jccs.199500097.

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33

Sebak, Mohamed, Fatma Molham, Claudio Greco, Mohamed A. Tammam, Mansour Sobeh, and Amr El-Demerdash. "Chemical diversity, medicinal potentialities, biosynthesis, and pharmacokinetics of anthraquinones and their congeners derived from marine fungi: a comprehensive update." RSC Advances 12, no. 38 (2022): 24887–921. http://dx.doi.org/10.1039/d2ra03610j.

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Marine-derived fungi receive excessive attention as prolific producers of structurally unique secondary metabolites. Whilst they are promising substitutes or conjugates for current therapeutics, so far research has only touched on their secondary metabolite diversity.

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Fusetani, Nobuhiro, Takeo Sugawara, and Shigeki Matsunaga. "Bioactive marine metabolites. 41. Theopederins A-E, potent antitumor metabolites from a marine sponge, Theonella sp." Journal of Organic Chemistry 57, no. 14 (July 1992): 3828–32. http://dx.doi.org/10.1021/jo00040a021.

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35

Nofiani, Risa. "Urgensi dan Mekanisme Biosintesis Metabolit Sekunder Mikroba Laut." Jurnal Natur Indonesia 10, no. 2 (November 20, 2012): 120. http://dx.doi.org/10.31258/jnat.10.2.120-125.

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Marine microorganism is one of biologically active potential resources of secondary metabolites. Its potency areso promising that the knowledge of how its secondary metabolite occured need to be studied and collected. Thoseknowledges will enable further study is improving secondary metabolite production in the laboratory. In nature,secondary metabolites synthesis occur when there are effect of both biotic and abiotic factors such as sea waterand microbe symbiosis with other living materials. When this is explained in metabolic pathways, secondarymetabolite synthesis affected by available nutrient and regulated by autoinducer molecules through quorum sensingmechanism

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36

Steven, Ray, Zalfa Humaira, Yosua Natanael, Fenny M. Dwivany, Joko P. Trinugroho, Ari Dwijayanti, Tati Kristianti, et al. "Marine Microbial-Derived Resource Exploration: Uncovering the Hidden Potential of Marine Carotenoids." Marine Drugs 20, no. 6 (May 26, 2022): 352. http://dx.doi.org/10.3390/md20060352.

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Microbes in marine ecosystems are known to produce secondary metabolites. One of which are carotenoids, which have numerous industrial applications, hence their demand will continue to grow. This review highlights the recent research on natural carotenoids produced by marine microorganisms. We discuss the most recent screening approaches for discovering carotenoids, using in vitro methods such as culture-dependent and culture-independent screening, as well as in silico methods, using secondary metabolite Biosynthetic Gene Clusters (smBGCs), which involves the use of various rule-based and machine-learning-based bioinformatics tools. Following that, various carotenoids are addressed, along with their biological activities and metabolic processes involved in carotenoids biosynthesis. Finally, we cover the application of carotenoids in health and pharmaceutical industries, current carotenoids production system, and potential use of synthetic biology in carotenoids production.

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Kato, Yuko, Nobuhiro Fusetani, Shigeki Matsunaga, Kanehisa Hashimoto, Shigeo Fujita, and Toshio Furuya. "Bioactive marine metabolites. Part 16. Calyculin A. A novel antitumor metabolite from the marine sponge Discodermia calyx." Journal of the American Chemical Society 108, no. 10 (May 1986): 2780–81. http://dx.doi.org/10.1021/ja00270a061.

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38

Fu, He, Mario Uchimiya, Jeff Gore, and Mary Ann Moran. "Ecological drivers of bacterial community assembly in synthetic phycospheres." Proceedings of the National Academy of Sciences 117, no. 7 (February 3, 2020): 3656–62. http://dx.doi.org/10.1073/pnas.1917265117.

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In the nutrient-rich region surrounding marine phytoplankton cells, heterotrophic bacterioplankton transform a major fraction of recently fixed carbon through the uptake and catabolism of phytoplankton metabolites. We sought to understand the rules by which marine bacterial communities assemble in these nutrient-enhanced phycospheres, specifically addressing the role of host resources in driving community coalescence. Synthetic systems with varying combinations of known exometabolites of marine phytoplankton were inoculated with seawater bacterial assemblages, and communities were transferred daily to mimic the average duration of natural phycospheres. We found that bacterial community assembly was predictable from linear combinations of the taxa maintained on each individual metabolite in the mixture, weighted for the growth each supported. Deviations from this simple additive resource model were observed but also attributed to resource-based factors via enhanced bacterial growth when host metabolites were available concurrently. The ability of photosynthetic hosts to shape bacterial associates through excreted metabolites represents a mechanism by which microbiomes with beneficial effects on host growth could be recruited. In the surface ocean, resource-based assembly of host-associated communities may underpin the evolution and maintenance of microbial interactions and determine the fate of a substantial portion of Earth’s primary production.

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Xiao, Shaoyujia, Nan Chen, Zixue Chai, Mengdie Zhou, Chenghaotian Xiao, Shiqin Zhao, and Xiliang Yang. "Secondary Metabolites from Marine-Derived Bacillus: A Comprehensive Review of Origins, Structures, and Bioactivities." Marine Drugs 20, no. 9 (September 6, 2022): 567. http://dx.doi.org/10.3390/md20090567.

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The marine is a highly complex ecosystem including various microorganisms. Bacillus species is a predominant microbialflora widely distributed in marine ecosystems. This review aims to provide a systematic summary of the newly reported metabolites produced by marine-derived Bacillus species over recent years covering the literature from 2014 to 2021. It describes the structural diversity and biological activities of the reported compounds. Herein, a total of 87 newly reported metabolites are included in this article, among which 49 compounds originated from marine sediments, indicating that marine sediments are majority sources of productive strains of Bacillus species Therefore, marine-derived Bacillus species are a potentially promising source for the discovery of new metabolites.

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40

Tringali, C. "Bioactive Metabolites From Marine Algae: Recent Results*." Current Organic Chemistry 1, no. 4 (November 1997): 375–94. http://dx.doi.org/10.2174/1385272801666220126161423.

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The recent literature (1992 - early 1996) on secondary metabolites from marine algae has been reviewed and selected results concerning more than one hundred bioactive compounds are reported. The review is specifically devoted to the seaweeds (Chlorophyta, Phaeophyta and Rhodophyta) and does not include metabolites from microalgae and Cyanobacteria (blue-green algae). Emphasis has been placed on novel compounds, but some recent reports about previously known bioactive metabolites have also been reviewed. A variety of bioactive metabolites has recently been obtained from marine algae, including terpenoids (among them the halogenated mono- and sesquiterpenoids typically produced by red algae), compounds of mixed biogenesis and further miscellaneous compounds. The reported activities range from properties of pharmacological interest, i.e. cytotoxicity against tumoral cultured cells, antimicrobial activity, antiviral activity, etc., to other activites of ecological or agronomical significance, such as antifeedant activity against marine predators or insecticidal activity. The review of the recent literature on secondary metabolites from marine algae indicates that the search for new bioactive metabolites from seaweeds is an active sector of the chemistry of natural products, stimulating the application of sophisticated physical techniques like two dimensional NMR as well as intriguing syntheses of compounds of biomedical interest.

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Xu, Lin, Kai-Xiong Ye, Wen-Hua Dai, Cong Sun, Lian-Hua Xu, and Bing-Nan Han. "Comparative Genomic Insights into Secondary Metabolism Biosynthetic Gene Cluster Distributions of Marine Streptomyces." Marine Drugs 17, no. 9 (August 26, 2019): 498. http://dx.doi.org/10.3390/md17090498.

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Bacterial secondary metabolites have huge application potential in multiple industries. Biosynthesis of bacterial secondary metabolites are commonly encoded in a set of genes that are organized in the secondary metabolism biosynthetic gene clusters (SMBGCs). The development of genome sequencing technology facilitates mining bacterial SMBGCs. Marine Streptomyces is a valuable resource of bacterial secondary metabolites. In this study, 87 marine Streptomyces genomes were obtained and carried out into comparative genomic analysis, which revealed their high genetic diversity due to pan-genomes owning 123,302 orthologous clusters. Phylogenomic analysis indicated that the majority of Marine Streptomyces were classified into three clades named Clade I, II, and III, containing 23, 38, and 22 strains, respectively. Genomic annotations revealed that SMBGCs in the genomes of marine Streptomyces ranged from 16 to 84. Statistical analysis pointed out that phylotypes and ecotypes were both associated with SMBGCs distribution patterns. The Clade I and marine sediment-derived Streptomyces harbored more specific SMBGCs, which consisted of several common ones; whereas the Clade II and marine invertebrate-derived Streptomyces have more SMBGCs, acting as more plentiful resources for mining secondary metabolites. This study is beneficial for broadening our knowledge about SMBGC distribution patterns in marine Streptomyces and developing their secondary metabolites in the future.

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Hoai Trinh, Phan Thi, Ngo Thi Duy Ngoc, Vo Thi Dieu Trang, Phi Quyet Tien, Bui Minh Ly, Tran Thi Thanh Van, Pham Duc Thinh, and Pham Trung San. "EFFECT OF CULTURE CONDITIONS FOR ANTIMICROBIAL ACTIVITY OF MARINE - DERIVED FUNGUS ASPERGILLUS FLOCCULOSUS 01NT.1.1.5." Vietnam Journal of Biotechnology 15, no. 4 (December 14, 2018): 721–28. http://dx.doi.org/10.15625/1811-4989/15/4/13415.

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The biosynthesis of compounds with antibiotic activity produced by marine fungi, strongly depends on their growth conditions. A good understanding of the role of culture conditions in the biosynthesis of metabolites may lead to better exploitation of microbial metabolites. In this study, the influence of culture conditions including incubation period, initial pH and salinity on antimicrobial activity and secondary metabolites production of marine fungus 01NT.1.1.5 was investigated. This isolate, obtained from sponge Stylissa sp. in Nha Trang Bay, exhibited a broad spectrum of in vitro antimicrobial activity to Bacillus cereus ATCC 11778, Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923, Listeria monocytogenes ATCC 19111, Streptococcus faecalis ATCC 19433 and Candida albicans ATCC 10231. According to morphological characteristics and sequence analysis of 28S rDNA, the fungus was identified as Aspergillus flocculosus. The results indicated that antimicrobial activity and metabolite amount were highest when the fungus was cultivated in rice medium with incubation period of 20 days. The optimum salinity of 35 g/L and initial pH of 6.0 were found for the maximum antibiotic production. The colony growth, antimicrobial activity and production of secondary metabolites of the strain A. flocculosus 01NT.1.1.5 varied depending on salt concentrations and initial pH of medium. Particularly, extract of this fungus only showed activity against C. albicans when it was cultured in medium with 30-35 g/L salinity and initial pH 4.0-8.0. The results indicate that salinity and initial pH along with cultivation period are important factors inﬂuencing antimicrobial activity and secondary metabolites of A. flocculosus 01NT.1.1.5, and might be for other marine fungi.

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Li, Tingting, Ting Ding, and Jianrong Li. "Medicinal Purposes: Bioactive Metabolites from Marine-derived Organisms." Mini-Reviews in Medicinal Chemistry 19, no. 2 (December 6, 2018): 138–64. http://dx.doi.org/10.2174/1389557517666170927113143.

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The environment of marine occupies about 95% biosphere of the world and it can be a critical source of bioactive compounds for humans to be explored. Special environment such as high salt, high pressure, low temperature, low nutrition and no light, etc. has made the production of bioactive substances different from terrestrial organisms. Natural ingredients secreted by marine-derived bacteria, fungi, actinomycetes, Cyanobacteria and other organisms have been separated as active pharmacophore. A number of evidences have demonstrated that bioactive ingredients isolated from marine organisms can be other means to discover novel medicines, since enormous natural compounds from marine environment were specified to be anticancer, antibacterial, antifungal, antitumor, cytotoxic, cytostatic, anti-inflammatory, antiviral agents, etc. Although considerable progress is being made within the field of chemical synthesis and engineering biosynthesis of bioactive compounds, marine environment still remains the richest and the most diverse sources for new drugs. This paper reviewed the natural compounds discovered recently from metabolites of marine organisms, which possess distinct chemical structures that may form the basis for the synthesis of new drugs to combat resistant pathogens of human life. With developing sciences and technologies, marine-derived bioactive compounds are still being found, showing the hope of solving the problems of human survival and sustainable development of resources and environment.

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Tziveleka, Leto-Aikaterini, Mohamed A. Tammam, Olga Tzakou, Vassilios Roussis, and Efstathia Ioannou. "Metabolites with Antioxidant Activity from Marine Macroalgae." Antioxidants 10, no. 9 (September 8, 2021): 1431. http://dx.doi.org/10.3390/antiox10091431.

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Reactive oxygen species (ROS) attack biological molecules, such as lipids, proteins, enzymes, DNA, and RNA, causing cellular and tissue damage. Hence, the disturbance of cellular antioxidant homeostasis can lead to oxidative stress and the onset of a plethora of diseases. Macroalgae, growing in stressful conditions under intense exposure to UV radiation, have developed protective mechanisms and have been recognized as an important source of secondary metabolites and macromolecules with antioxidant activity. In parallel, the fact that many algae can be cultivated in coastal areas ensures the provision of sufficient quantities of fine chemicals and biopolymers for commercial utilization, rendering them a viable source of antioxidants. This review focuses on the progress made concerning the discovery of antioxidant compounds derived from marine macroalgae, covering the literature up to December 2020. The present report presents the antioxidant potential and biogenetic origin of 301 macroalgal metabolites, categorized according to their chemical classes, highlighting the mechanisms of antioxidative action when known.

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Moran, Mary Ann, Elizabeth B. Kujawinski, William F. Schroer, Shady A. Amin, Nicholas R. Bates, Erin M. Bertrand, Rogier Braakman, et al. "Microbial metabolites in the marine carbon cycle." Nature Microbiology 7, no. 4 (April 2022): 508–23. http://dx.doi.org/10.1038/s41564-022-01090-3.

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Christophersen, Carsten, H. Bazin, J. Heikkilä, J. Chattopadhyaya, Gotfryd Kupryszewski, and Bo Wigilius. "Secondary Metabolites from Marine Bryozoans. A review." Acta Chemica Scandinavica 39b (1985): 517–29. http://dx.doi.org/10.3891/acta.chem.scand.39b-0517.

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Rateb, Mostafa E., and Rainer Ebel. "Secondary metabolites of fungi from marine habitats." Natural Product Reports 28, no. 2 (2011): 290. http://dx.doi.org/10.1039/c0np00061b.

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TADA, HARUHIKO, and FUMIO YASUDA. "Metabolites from the marine sponge Epipolasis kushimotoensis." CHEMICAL & PHARMACEUTICAL BULLETIN 33, no. 5 (1985): 1941–45. http://dx.doi.org/10.1248/cpb.33.1941.

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Amico, Vincenzo, Mario Piattelli, Mario Bizzini, and Placido Neri. "Absolute Configuration of Some Marine Metabolites fromCystoseiraspp." Journal of Natural Products 60, no. 11 (November 1997): 1088–93. http://dx.doi.org/10.1021/np9700432.

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Shigemori, Hideyuki, Masami Tenma, Kengo Shimazaki, and Jun'ichi Kobayashi. "Three New Metabolites from the Marine YeastAureobasidiumpullulans." Journal of Natural Products 61, no. 5 (May 1998): 696–98. http://dx.doi.org/10.1021/np980011u.

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Journal articles on the topic 'Marine metabolites'

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