Academic literature on the topic 'Marine metabolites'

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Journal articles on the topic "Marine metabolites"

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Pirog, T. P. "PRACTICALLY VALUABLE METABOLITES OF MARINE MICROORGANISMS." Biotechnologia Acta 13, no. 3 (June 2020): 5–29. http://dx.doi.org/10.15407/biotech13.03.005.

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Uras, İbrahim Seyda, and Belma Konuklugil. "Anticancer secondary metabolites from marine sponges." Ege Journal of Fisheries and Aquatic Sciences 38, no. 1 (March 15, 2021): 101–6. http://dx.doi.org/10.12714/egejfas.38.1.12.

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The oceans cover 70% of the Earth’s surface. The marine environment is an important source of secondary metabolites with high biodiversity. Besides other marine species, sponges with a wide range of secondary metabolites are an important potential for drug discovery. Cancer is one of the leading causes of death with high morbidity and mortality. It is very important to discover new therapeutic agents in the treatment of cancer. In recent years, studies on exploring new anticancer compounds are focused on the marine source. In this review, our target is collecting the studies about marine sponges secondary metabolites which have an anticancer effect. Among most of the isolated compounds from sponges and their semisynthetic derivatives, there are three FDA (US Food and Drug Administration) approved compounds and three compounds in clinical phase. Moreover, more than 40 compounds isolated from marine sponges have been tested for anticancer activity in recent 10 years. In conclusion marine sponges secondary metabolites are a promising and important source of the anticancer compounds.
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Blunden, Gerald. "Metabolites from marine algae." Progress in Oceanography 21, no. 2 (January 1988): 217–26. http://dx.doi.org/10.1016/0079-6611(88)90041-9.

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Fenizia, Simona, Jerrit Weissflog, and Georg Pohnert. "Cysteinolic Acid Is a Widely Distributed Compatible Solute of Marine Microalgae." Marine Drugs 19, no. 12 (November 30, 2021): 683. http://dx.doi.org/10.3390/md19120683.

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Phytoplankton rely on bioactive zwitterionic and highly polar small metabolites with osmoregulatory properties to compensate changes in the salinity of the surrounding seawater. Dimethylsulfoniopropionate (DMSP) is a main representative of this class of metabolites. Salinity-dependent DMSP biosynthesis and turnover contribute significantly to the global sulfur cycle. Using advanced chromatographic and mass spectrometric techniques that enable the detection of highly polar metabolites, we identified cysteinolic acid as an additional widely distributed polar metabolite in phytoplankton. Cysteinolic acid belongs to the class of marine sulfonates, metabolites that are commonly produced by algae and consumed by bacteria. It was detected in all dinoflagellates, haptophytes, diatoms and prymnesiophytes that were surveyed. We quantified the metabolite in different phytoplankton taxa and revealed that the cellular content can reach even higher concentrations than the ubiquitous DMSP. The cysteinolic acid concentration in the cells of the diatom Thalassiosira weissflogii increases significantly when grown in a medium with elevated salinity. In contrast to the compatible solute ectoine, cysteinolic acid is also found in high concentrations in axenic algae, indicating biosynthesis by the algae and not the associated bacteria. Therefore, we add this metabolite to the family of highly polar metabolites with osmoregulatory characteristics produced by phytoplankton.
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Sedaca, Albetina. "Urgency and Mechanism of Biosynthesis of Marine Microbial Secondary Metabolites." International Journal of Science and Society 2, no. 4 (September 11, 2020): 159–66. http://dx.doi.org/10.54783/ijsoc.v2i4.201.

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Marine microorganism is one of biologically active potential resources of secondary metabolites. Its potency are so promising that the knowledge of how its secondary metabolite occured need to be studied and collected. Those knowledges will enable further study is improving secondary metabolite production in the laboratory. In nature, secondary metabolites synthesis occur when there are effect of both biotic and abiotic factors such as sea water and microbe symbiosis with other living materials. When this is explained in metabolic pathways, secondary metabolite synthesis affected by available nutrient and regulated by autoinducer molecules through quorum sensing mechanism.
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Edward Amado. "Urgency and Mechanism of Biosynthesis of Marine Microbial Secondary Metabolites." INFLUENCE : International Journal of Science Review 3, no. 3 (November 29, 2021): 229–34. http://dx.doi.org/10.54783/influence.v3i3.181.

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Marine microorganism is one of biologically active potential resources of secondary metabolites. Its potency are so promising that the knowledge of how its secondary metabolite occured need to be studied and collected. Those knowledges will enable further study is improving secondary metabolite production in the laboratory. In nature, secondary metabolites synthesis occur when there are effect of both biotic and abiotic factors such as sea water and microbe symbiosis with other living materials. When this is explained in metabolic pathways, secondary metabolite synthesis affected by available nutrient and regulated by autoinducer molecules through quorum sensing mechanism
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Andryukov, Boris, Valery Mikhailov, and Nataly Besednova. "The Biotechnological Potential of Secondary Metabolites from Marine Bacteria." Journal of Marine Science and Engineering 7, no. 6 (June 3, 2019): 176. http://dx.doi.org/10.3390/jmse7060176.

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Marine habitats are a rich source of molecules of biological interest. In particular, marine bacteria attract attention with their ability to synthesize structurally diverse classes of bioactive secondary metabolites with high biotechnological potential. The last decades were marked by numerous discoveries of biomolecules of bacterial symbionts, which have long been considered metabolites of marine animals. Many compounds isolated from marine bacteria are unique in their structure and biological activity. Their study has made a significant contribution to the discovery and production of new natural antimicrobial agents. Identifying the mechanisms and potential of this type of metabolite production in marine bacteria has become one of the noteworthy trends in modern biotechnology. This path has become not only one of the most promising approaches to the development of new antibiotics, but also a potential target for controlling the viability of pathogenic bacteria.
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Kijjoa, Anake, Rawiwan Watanadilok, Pichai Sonchaeng, Pichan Sawangwong, Madalena Pedro, Maria São José Nascimento, Artur M. S. Silva, Graham Eaton, and Werner Herz. "Further Halotyrosine Derivatives from the Marine Sponge Suberea aff. praetensa." Zeitschrift für Naturforschung C 57, no. 7-8 (August 1, 2002): 732–38. http://dx.doi.org/10.1515/znc-2002-7-831.

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Reexamination of the marine sponge Suberea aff. praetensa, (Row) from the Gulf of Thailand furnished in addition to bromotyrosine derivatives found previously 5-bromo- and 5- chlorocavernicolin, cavernicolins 1 and 2, two other brominated tyrosine metabolites, a known bisoxazolidone and a new unusual rearranged tyrosine metabolite subereatensin. Several of the metabolites exhibited significant inhibitory effects against five human cancer cell lines.
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Handley, Jackie T., and Adrian J. Blackman. "Secondary Metabolites from the Marine Alga Caulerpa brownii (Chlorophyta)." Australian Journal of Chemistry 58, no. 1 (2005): 39. http://dx.doi.org/10.1071/ch04174.

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The green seaweed Caulerpa brownii (Chlorophyta, Caulerpaceae) occurs in Tasmania in two morphological forms (branched and unbranched) and each form has a different profile of diterpenoid secondary metabolites. Unbranched specimens gave rise to the novel secondary metabolites 11, 13, 14, 17, and 18, the secondary metabolite 8 that has been isolated for the first time as a natural product, as well as the known compounds 1 and 3–7. Branched specimens of C. brownii yielded the novel terpenoid esters 21 and the known compounds 1 and 2.
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Li, Hong-yu, Shigeki Matsunaga, and Nobuhiro Fusetani. "Antifungal Metabolites from Marine Sponges." Current Organic Chemistry 2, no. 6 (November 1998): 649–82. http://dx.doi.org/10.2174/1385272802666220130083412.

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Ease in collecting relatively large amounts of diverse species together with a high incidence of active samples has made marine sponges a good source of antifungal compounds. Although classical antimicrobial screening is now replaced by more disease-oriented sophisticated screening, many antifungal compounds with a wide structural diversity have been reported from marine sponges in the long history of the search for these compounds. In this review we describe antifungal compounds isolated from marine sponges since 1987 according to their structural types.
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Dissertations / Theses on the topic "Marine metabolites"

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Fish, Paul Vincent. "Synthetic studies towards marine metabolites." Thesis, University of Nottingham, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235997.

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Pathirana, Induruwa Charles. "Secondary metabolites from selected marine organisms." Thesis, University of British Columbia, 1986. http://hdl.handle.net/2429/27506.

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Marine organisms are known to produce secondary metabolites which have novel structures and are often biologically active. Chemical studies of biologically active metabolites from three different marine organisms led to the discovery of six new compounds and six previously known compounds. The brown alga Dictyota binghamiae is fairly abundant in British Columbia coastal waters. A chemical study of this alga yielded ten diterpenoids of which four are new compounds. All the new compounds, dictyoxide A (66), dictyol G acetate (68), dictyotriol A diacetate (69), and epidictyol B acetate (70) contain a perhydroazulene carbon skeleton first encountered in the algal metabolite pachydictyol A (29). Dictyoxide A (66) appears to be an artifact of isolation. The acetates 68, 69, 70 were found to be antibacterial and antifungal. Six previously known compounds pachydictyol A (29), dictyol C (32), dictyoxide (35), acetyldictyolal (49) and the acetals 61a and 61b were also isolated from this alga. Chemical studies on an Agelas sp. of sponge collected in Sri Lanka yielded the antimicrobial metabolite desbromooroidin (79). An interesting interaction between the starfish Dermasterias imbricata and the sea anemone Stompia coccinea was observed a long time ago. When contacted by the starfish, the anemone displays an unusual "swimming" response which was, according to other subsequent studies, caused by a single chemical substance in the starfish. A study conducted to elucidate the structure of this starfish metabolite led to the isolation of imbricatine (91), a unique benzyltetrahydroisoquinoline alkaloid. Imbricatine (91) induced S. coccinea swimming response at a very low concentration and also exhibited antitumor activity. Structures of all the new metabolites were determined by spectral analysis, and chemical degradations and chemical interconversions.
Science, Faculty of
Chemistry, Department of
Graduate
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Wojnar, Joanna M. "Isolation of new secondary metabolites from New Zealand marine invertebrates : a thesis submitted to the Victoria University of Wellington in fulfilment of the requirements for the degree of Doctor of Philosophy in Chemistry /." ResearchArchive@Victoria e-Thesis, 2008. http://hdl.handle.net/10063/630.

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Mostafa, Wael M. Abdel-Mageed. "Investigations of secondary metabolites from marine organisms." Thesis, Available from the University of Aberdeen Library and Historic Collections Digital Resources. Online version available for University member only until Sep. 1, 2014, 2009. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=53365.

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Miao, Shichang. "Novel secondary metabolites from selected marine invertebrates." Thesis, University of British Columbia, 1991. http://hdl.handle.net/2429/31133.

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Chemical studies of a Northeastern Pacific tunicate and three Papua New Guinea sponges have led to the isolation of sixteen new secondary metabolites. The structures of the new compounds were determined by spectroscopic analysis and chemical interconversions. The absolute stereochemistry of imbricatine, a previously reported starfish metabolite, has also been determined. The northeastern Pacific tunicate Ritterella rubra has been found to contain a novel series of aromatic butenolides, rubrolides A-H (149-156). The structures of the rubrolides were solved by the analysis of NMR (¹H, ¹³C, COSY, nOe, HETCOR, FLOCK, HMQC and HMBC), MS and IR data combined with chemical interconversions. FLOCK, a new ¹H/¹³C long-range correlation experiment, played a key role in establishing the rubrolide carbon skeleton. The rubrolides represent the largest family of non-nitrogenous tunicate metabolites. The protein phosphatase inhibitory activity and the potent antibiotic activities of the rubrolides warrant further investigation. The absolute stereochemistry of imbricatine (179), a compound reported from the starfish Dermasterias imbricata, has been determined by comparing the optical properties of its chemical degradation products with those of model compounds. Raney nickel reduction of 179 yielded benzyltetrahydroisoquinoline 188a which was methylated to give 188b. Comparison between the CD spectrum of 188b and those of model compounds 189 and 190 solved the absolute stereochemistry of the tetrahydroisoquinoline fragment of 179. Reductive hydrolysis of 179 followed by oxidation yielded histidine disulphide 182. Comparison of the optical rotation of 182 with the reported value solved the absolute stereochemistry of the histidine fragment of 179. Attempts to study the biogenesis of 179 were unsuccessful. Examination of three Papua New Guinea sponges resulted in the isolation of eight new compounds. Six new bastadins (211-216) were isolated from Ianthella basta. The structures were elucidated by spectroscopic analysis as well as comparison with the previously reported bastadins. A Xestospongia species was found to contain xestospongin E (238), a new metabolite, and a number of known xestospongins. Both the bastadins and the xestospongins possess antibiotic and cytotoxic activities. A symmetrical enyne, callydiyne (247), was isolated from Callyspongia flammea. The structure of 247 was determined by spectroscopic studies.
Science, Faculty of
Chemistry, Department of
Graduate
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Tischler, Mark. "Secondary metabolites from selected British Columbian marine organisms." Thesis, University of British Columbia, 1987. http://hdl.handle.net/2429/26650.

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The two purine alkaloids, phidolopin (36) and desmethylphidolopin (37), originally isolated from Phidolopora pacifica, were synthesized in order to produce sufficient quantities of the natural products for extended biological and pharmacological screening and to confirm the previous structural assignment of 37 which was based on spectral data. Various combinations of phidolopin (36), desmethylphidolopin (37), 4-hydroxymethyl-2-nitrophenol (38) and 4-methoxymethyl-2-nitrophenol (39) were isolated from four different species of bryozoans, Diaperoecia californica, Heteropora alaskensis, Tricellaria ternata and Hippodiplosia insculpta. A dietary origin is suggested for these metabolites. The red sponge, Anthoarcuata graceae yielded six novel steroids including the ∆⁴-3,6-diketosteroids 116, 117, the A-nor steroids anthosterone A (118) and anthosterone B (119) as well as two diosphenol containing steroids, 120 and 121. The proposed structures were based on a combination of spectral analysis, chemical interconversions, synthesis, and single crystal X-ray diffraction analysis.
Science, Faculty of
Chemistry, Department of
Graduate
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Morris, Sandra Anne. "Novel secondary metabolites isolated from selected marine invertebrates." Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/31073.

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A study of the secondary metabolism of two northeastern Pacific sponges and two Sri Lankan nudibranchs has led to the isolation of thirteen new and one previously known natural products. The structures of all of the compounds were determined by a combination of spectroscopic data analysis and chemical interconversions. A study of the chemistry of the northeastern Pacific sponge Hexadella sp. has resulted in the isolation of six new brominated alkaloids. Two of these, hexadellins A (77) and B (78), are derived from dibromotyrosine. The structures of compounds 77 and 78 were determined via their acetylated derivatives 79 and 80. Four compounds possessing novel bis(indole) structures have also been isolated. Topsentin B2 (74) was isolated as a mixture of two slowly interconverting tautomers, 74a and 74b. Methylation of 74 resulted in the production of trimethyltopsentin B2 (75); the structure of 75 was determined spectroscopically. The structures of dragmacidons A (81), B (82), and C (83) were determined by a combination of spectral data interpretation and chemical interconversions. Dragmacidon C (83) was originally incorrectly assigned as 88; the correct structure was determined based upon synthesis of the model compound 94. Compounds 77 and 78 possess antimicrobial activities. Compounds 74 and 81 show considerable cytotoxic and antineoplastic activities. Five new triterpene glycosides have been isolated from the northeastern Pacific sponge Xestospongia vanilla. The structures of isoxestovanin A (125), xestovanin C (127), dehydroxestovanin A (129), epi-dehydroxestovanin A (131), and dehydroxestovanin C (132) were all determined by a combination of spectral data interpretation and chemical interconversions. These compounds all contain the deoxy sugars L-rhamnose and D-fucose. Isoxestovanin A (125) possesses a new carbon skeleton and xestovanin C (127) and dehydroxestovanin C (132) possess linear trisaccharide fragments which have not been previously encountered in triterpene glycosides isolated from X. vanilla. The Sri Lankan nudibranch Chromodoris glenei has yielded the known compound 12-desacetoxyshahamin C (153) and the new metabolite shahamin K (155). Both compounds possess dendrillane diterpene skeletons. The compound chromodorolide B (156) was isolated from specimens of Chromodoris cavae. It is only the second known diterpene natural product possessing the chromodorane skeleton.
Science, Faculty of
Chemistry, Department of
Graduate
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Dewi, Ariyanti Suhita. "Biologically active secondary metabolites from tropical marine invertebrates." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/15299.

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In our effort to discover promising anticancer agents, we have screened a series of compounds for their activities as indoleamine-2,3-dioxygenase (IDO) inhibitor and SHcontaining inositol 5-phosphatase (SHIP1) activator. In comparison to aaptamine (2.1) and demethylaaptamine (2.2), isoaaptamine (2.4) from Aaptos cf. suberitoides appears to be the most promising IDO inhibitor with an IC₅₀ of 0.00215 mg/mL, owing to the presence of hydroxyl group at C9 position and the methylation at N1 position. A study on the sponge extract of RJA 55275 for its SHIP activator yielded theonellapeptolide Id (3.4), the first peptide that enhanced the SHIP with 25% activity at concentration 124 μM, thus makes it the most potent SHIP activator known to date. The third project studied the crystals of a novel eunicellin-based diterpenoid (4.39) with a modest SHIP activity from an unidentified Micronesian soft coral RJA 47686. The X-ray analysis illustrated that the crystals are monoclinic, space group P21/b, with a = 9.3711(14) A; α = 90⁰; b = 13.5349(17) A; β = 99.142(7)⁰; c = 10.9891(17) A; γ = 90⁰; V = 1376.1 (3) ų; Z value = 2; Dcalc 1.189. 10-³ g/cm³; F₀₀₀ 536.00; Cu (MoKα) 0.84 cm-¹. Based on the NMR and x–ray data 4.39 was shown to possess (1R*, 2R*, 3R*, 6R*, 7S*, 10R*, 14R*, 18R*)-configuration with an ether linkage connecting C2 and C6.
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Tabudravu, Jioji N. "Investigations of secondary metabolites from Fijian marine sponges." Thesis, University of Aberdeen, 2001. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU602042.

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The following thesis presents results from investigations of marine natural products. It is divided into 7 chapters consisting of an introduction, five chapters examining the metabolites from Fijian marine sponges and one chapter examining the secondary metabolites from the medicinal plant, kava {Piper methysticum). Two new psammaplins (psammaplin K and L), a new isomalabaricane triterpene monosaccharide, two new bromotyrosine alkaloids (purealidin S and purpureamine J) and two new cyclic peptides (axinellin C and wainunuamide), a new conformer of phakellistatin 2 together with other known secondary metabolites were isolated from marine sponges. The new conformer of phakellistatin 2 was observed to adopt another conformation in CDCI3. Psammaplin A was found to inhibit chitinase from a Bacillus sp. and Serratia marcescens. The mode of activity was investigated by enzyme reaction kinetics and supported by X-ray crystallography. A new isomer of flavokavain A, woflavokavain A was isolated from kava, together with 7 known compounds. Solution conformations of axinellin C, jasplakinolide, phakellistatin 2 and its two conformers were generated using nOe restrained molecular modelling techniques.
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Drainville-Higgins, Katherine Evelyn. "Isolation of marine metabolites from S̲y̲m̲b̲i̲o̲d̲i̲n̲i̲u̲m̲ species of dinoflagellates /." View online ; access limited to URI, 2004. http://0-wwwlib.umi.com.helin.uri.edu/dissertations/dlnow/3135901.

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Books on the topic "Marine metabolites"

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Sarma, Aluru S. Secondary metabolites from marine sponges. Berlin: Ullstein Mosby, 1993.

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Marsh, Jane Wendy. Formation of genotoxic xenobiotic metabolites in marine organisms. Birmingham: University of Birmingham, 1991.

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Indriani, Ine Dewi. Biodiversity of marine-derived fungi and identification of their metabolites: = Biodiversität von Pilzen mariner Herkunft und Identifizierung ihrer Sekundärstoffe. Göttingen: Cuvillier, 2008.

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Pivkin, M. V. Morskie griby i ikh metabolity. Vladivostok: Dalʹnauka, 2006.

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Nagle, Dale George. Novel oxylipins and other bioactive metabolites from marine algae. 1994.

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Scheuer, Paul J. Bioorganic Marine Chemistry Volume 6: SYNTHESIS OF MARINE NATURAL PRODUCTS PT.2 - NONTERPENOIDS (BIOORGANIC MARINE CHEMISTRY). Edited by Paul Scheuer. Springer, 1992.

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Mary-Frances, Thompson, Sarojini Rachakonda, Nagabhushanam Rachakonda, United States. Office of Naval Research. Chemical and Oceanic Biology Program., American Institute of Biological Sciences., and Marathwada Universtiy, eds. Bioactive compounds from marine organisms: With emphasis on the Indian Ocean : an Indo-United States symposium. New Delhi: Oxford & IBH Pub. Co., 1991.

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Rossi, James V. Biosynthetic investigations of two secondary metabolites from the marine cyanobacterium Lyngbya majuscula. 1997.

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Wu, Min. Novel bioactive secondary metabolites from the marine cyanobacterium Lyngbya majuscula. 1996.

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J, Scheuer Paul, and Albizati Kim Francis 1954-, eds. Synthesis of marine natural products. Berlin: Springer-Verlag, 1992.

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Book chapters on the topic "Marine metabolites"

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Banaigs, Bernard, Isabelle Bonnard, Anne Witczak, and Nicolas Inguimbert. "Marine Peptide Secondary Metabolites." In Outstanding Marine Molecules, 285–318. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2014. http://dx.doi.org/10.1002/9783527681501.ch13.

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Albizati, K. F., V. A. Martin, M. R. Agharahimi, and D. A. Stolze. "Nitrogenous Metabolites." In Synthesis of Marine Natural Products 2, 158–248. Berlin, Heidelberg: Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-76838-5_3.

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Albizati, K. F., V. A. Martin, M. R. Agharahimi, and D. A. Stolze. "Miscellaneous Metabolites." In Synthesis of Marine Natural Products 2, 249–310. Berlin, Heidelberg: Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-76838-5_4.

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Ebada, Sherif S., and Peter Proksch. "Marine-Derived Fungal Metabolites." In Hb25_Springer Handbook of Marine Biotechnology, 759–88. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-53971-8_32.

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Gomes, Ana R., Armando C. Duarte, and Teresa A. P. Rocha-Santos. "Analytical Techniques for Discovery of Bioactive Compounds from Marine Fungi." In Fungal Metabolites, 415–34. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-25001-4_9.

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Gomes, Ana R., Armando C. Duarte, and Teresa A. P. Rocha-Santos. "Analytical Techniques for Discovery of Bioactive Compounds from Marine Fungi." In Fungal Metabolites, 1–20. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-19456-1_9-1.

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Hu, Jing, Bin Yang, Xiuping Lin, Xue-Feng Zhou, Xian-Wen Yang, and Yonghong Liu. "Bioactive Metabolites from Seaweeds." In Handbook of Marine Macroalgae, 262–84. Chichester, UK: John Wiley & Sons, Ltd, 2011. http://dx.doi.org/10.1002/9781119977087.ch12.

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Kim, Se-Kwon, and Pradeep Dewapriya. "Anticancer Potentials of Marine-Derived Fungal Metabolites." In Marine Microbiology, 237–45. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2013. http://dx.doi.org/10.1002/9783527665259.ch14.

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Rinehart, Kenneth L. "Secondary Metabolites from Marine Organisms." In Ciba Foundation Symposium 171 - Secondary Metabolites: their Function and Evolution, 236–54. Chichester, UK: John Wiley & Sons, Ltd., 2007. http://dx.doi.org/10.1002/9780470514344.ch14.

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Mukesh, K., Miryam Z. Sahni, Valadmir Belenky Wahrman, and Gurdial M. Sharma. "Secondary Metabolites of Marine Organisms." In New Developments in Marine Biotechnology, 41–47. Boston, MA: Springer US, 1998. http://dx.doi.org/10.1007/978-1-4757-5983-9_9.

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Conference papers on the topic "Marine metabolites"

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Pei-Sheng, Yan, Shi Cui-Juan, Hou Chun-Chun, and Kan Guang-Feng. "Inhibition of vomitoxin-producing Fusarium graminearum by marine actinomycetes and the extracellular metabolites." In 2011 International Conference on Human Health and Biomedical Engineering (HHBE). IEEE, 2011. http://dx.doi.org/10.1109/hhbe.2011.6028029.

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Alfattani, A., EF Ferreira Queiroz, L. Marcourt, S. Leoni, P.-M. Allard, K. Perron, D. Stien, K. Gindro, and J.-L. Wolfender. "Efficient isolation of new bioactive metabolites from the marine endophytic fungi Fusarium solani." In 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) in cooperation with the French Society of Pharmacognosy AFERP. © Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-3399828.

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Bounnit, Touria, Imen Saadaoui, Rihab Rasheed, Hareb Al jabri, Sami Sayadi, and Ahmad Ayesh. "Assessment of SnO2 Nanoparticles’ Impact on local Pichoclorum Atomus Growth Performance, Cell Morphology and Metabolites Content." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2021. http://dx.doi.org/10.29117/quarfe.2021.0034.

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Oxide nanoparticles are among the most used nanomaterials and have received considerable attention over their potential ecological effects. Increasing investigations report toxicity of certain oxide nanoparticles, however, there are also studies showing opposite results, highlighting the fact that these nanoparticles may differ in their toxicological effects, which depend on particle variety and size, test organism species, and test method. The current study investigates the ecotoxicity of SnO2 nanoparticles on a local marine algae isolate. Five different concentrations (1, 5, 25, 50 and 100mg/L) were tested and the culture was followed for 72h. Algae growth, morphology and metabolites were followed each 24h. The obtained data showed that the SnO2 presented a toxicity on the algae growth that was decreasing with the dose, with lower doses presenting more negative impacts than the higher doses. In parallel, the slow growth observed at 1-5 mg/L was explained by the dramatic damages caused by the SnO2 on the cell morphology, which was detected using the scanning electronic microscopy. Indeed, this low negative impact of higher concentrations of SnO2 (50-100mg/L) is explained by the high agglomeration of ten particles leading to reduced effect on the cell morphology and health. Furthermore, and in accordance with the morphological data, the metabolites analysis data revealed that SnO2 nanoparticles induced stress, which was manifested by an increase in the lipid content and decrease in the proteins, a metabolite that is involved in the algal growth.
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Hartmann, A., M. Orfanoudaki, P. Blanchard, S. Derbre, A. Schinkovitz, P. Richomme, M. Ganzera, and H. Stuppner. "Secondary metabolites from marine sources as inhibitors of advanced glycation end products (AGEs) and collagenase." In 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) in cooperation with the French Society of Pharmacognosy AFERP. © Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-3400086.

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Cherif, Maroua, Touria Bounnit, Hareb Al JAbri, and Imen Saadaoui. "Improvement of Omega-3-rich Microalgae Biomass Production to Support Qatar Food Security." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0035.

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Recently, algae have received considerable interest as one of the most promising feedstocks suitable for animal feed production due to their fast growth, less nutrient requirements and their ability to produce primary and secondary metabolites with high-added value. Different strategies were applied to improve both biomass and metabolites productivities aiming to produce highquality biomass with low cost and high nutritional value. Tetraselmis subcoliformis QUCCCM50, a local marine green alga presenting fast growth, high metabolites content and easy to harvest, was selected as a candidate for feed production. Three different stress conditions were applied to enhance its potential to produce high-value products such as Nitrogen or Phosphorus depletion and high salinity of 100ppt. An assessment of the growth properties and biomass productivity was performed during the growth. After 15 days of cultivation using tubular photobioreactors, the biomass was subjected to metabolites characterization and fatty acids methyl ester profiling. Results showed that the three stress conditions present different impacts on biomass productivity and, lipid quantity and quality. Cultivation under 100 ppt led to the highest increase in lipid content. This culture condition led to 25% increase of the omega-3 fatty acids with the appearance of the docosahexaenoic acid (DHA) and a remarkable increase of the alpha-linolenic acid, comparatively to the control. The enrichment of the Tetraselmis subcoliformis’ biomass in terms of omega-3 fatty acids enhance its nutritional value and make it very suitable for animal feed production. The optimized culture conditions obtained from the current study will be applied at large scale to enhance the quality of the biomass towards omega-3 enriched animal feed supplement production, and hence support achieving food security in the State of Qatar.
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Nikolaou, IA, N. Tsafantakis, P. Vlachou, E. Baira, A. Sklirou, G. le Goff, C. Cheimonidi, et al. "Investigation of the marine microorganism Cladosporium halotolerans for the isolation and identification of bioactive metabolites with potential anti-aging activity." In 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) in cooperation with the French Society of Pharmacognosy AFERP. © Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-3399892.

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Shaikh, Saame (Raz), Anandita Pal, and Ian Carroll. "Eicosapentaenoic acid ethyl esters prevent obesity-driven impairments to glucose homeostasis through the biosynthesis of downstream hydroxylated metabolites." In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/colx6433.

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There is considerable debate on the clinical utility of the long n-3 polyunsaturated fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) for preventing dysregulation of obesity-driven glucose homeostasis. Herein, we first show that administration of ethyl esters of EPA, but not DHA, to C57BL/6J male mice improves hyperglycemia, hyperinsulinemia, and glucose tolerance. Mechanistically, we demonstrate that EPA reverses the obesity-driven decrease in the concentration of white adipose tissue and liver 18-hydroxyeicosapentaenoic acid (18-HEPE), the precursor for resolvin E1 (RvE1). A combination of add-back and receptor knockout experiments reveal that RvE1 is specifically driving the improvement in hyperinsulinemia and hyperglycemia through the receptor known as ERV1/ChemR23 by controlling pathways related to hepatic glucose metabolism and inflammation. Next, we show that EPA’s effects are distinct in female mice as EPA administration leads to improvements in body weight, hyperinsulinemia and hyperglycemia but not glucose tolerance. In this case, EPA exerts its effects through a mechanism potentially mediated by 8-HEPE and upregulation of key intestinal microbes. Finally, we present translation data showing that glucose levels in humans with obesity are inversely related to EPA but not DHA in a sex-specific manner. Furthermore, data from our pilot clinical trial demonstrate that an 18-HEPE-enriched marine oil supplement increases RvE1 levels by 3-fold in humans with obesity. Taken together, these results provide clarity to the field by suggesting that EPA but not DHA ethyl esters can prevent glucose dysregulation in a sex-specific manner through distinct mechanisms mediated by downstream hydroxylated metabolites.
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Ritterbush, Kathleen A. "BIOENERGETICS OF EARLIEST JURASSIC MARINE ECOSYSTEMS: SLOW METABOLISMS, SLOW CARBON CYCLING." In GSA Annual Meeting in Indianapolis, Indiana, USA - 2018. Geological Society of America, 2018. http://dx.doi.org/10.1130/abs/2018am-324153.

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Dalgamouni, Tasneem atef, Shatha Kanji, Maroua Cherif, Rihab Rasheed, Touria Bounnit, Hareb Aljabri, Imen Saadaoui, and Radhouane Ben Hamadou. "Isolation, Cultivation, and Characterization of Novel Local Marine Micro-Algae for Aquaculture Feed Supplement Production." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0037.

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Aquaculture is considered as a promising alternative to support the food demands of the everincreasing population. Currently, this sector faces several challenges such as using fishmeal, which is unsustainable and expensive. Therefore, it is necessary to identify an alternative feed component that is sustainable, cost-effective and can provide the essential nutrients required by the fish. In this context, microalgae are considered as a viable source of proteins, lipids, polysaccharides and highvalue products (HVPs) such as essential fatty acids, amino acids and vitamins. They play a vital role in the marine food chain and hence can be easily assimilated by the fish. The current research targeted the isolation, identification and characterization of novel marine microalgae from Qatar coastline to produce aquaculture feed supplement. As the climate poses a number of stress factors, such as high light intensities, temperatures and varying salinities, it is expected that novel microalgae with interesting metabolite profiles can be isolated from the environment for developing aquaculture sector in Qatar. Standard plating methods were used to isolate halophilic strains from field waters. PCR-sequencing was used to identify the novel microalgae, cyanobacteria and diatom isolates. Then a comparative analysis of the growth performance and metabolite content was performed to characterize these strains. Results evidenced that the cyanobacteria strain exhibited the highest biomass productivity of 51.4 mg L-1day-1 whereas the highest lipid content was observed in the novel diatom isolate ranging up to 28.62% and the highest amount of carotenoids was detected in the case of the microalgae. As in conclusion, a rich feed supplement blending the three isolates can be considered as an alternative to fishmeal. As a continuation of this research, the potential strains will be cultivated under various stress to increase their nutritional value.
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Marzuki, Ismail, Sri Gusty, Rakhmad Armus, Ajuk Sapar, Ruzkiah Asaf, Andi Athirah, and Jaya. "Secondary metabolite analysis and anti-bacterial and fungal activities of marine sponge methanol extract based on coral cover." In INTERNATIONAL CONFERENCE ON ENERGY AND ENVIRONMENT (ICEE 2021). AIP Publishing, 2021. http://dx.doi.org/10.1063/5.0059500.

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Reports on the topic "Marine metabolites"

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Fait, Aaron, Grant Cramer, and Avichai Perl. Towards improved grape nutrition and defense: The regulation of stilbene metabolism under drought. United States Department of Agriculture, May 2014. http://dx.doi.org/10.32747/2014.7594398.bard.

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The goals of the present research proposal were to elucidate the physiological and molecular basis of the regulation of stilbene metabolism in grape, against the background of (i) grape metabolic network behavior in response to drought and of (ii) varietal diversity. The specific objectives included the study of the physiology of the response of different grape cultivars to continuous WD; the characterization of the differences and commonalities of gene network topology associated with WD in berry skin across varieties; the study of the metabolic response of developing berries to continuous WD with specific attention to the stilbene compounds; the integration analysis of the omics data generated; the study of isolated drought-associated stress factors on the regulation of stilbene biosynthesis in plantaand in vitro. Background to the topic Grape quality has a complex relationship with water input. Regulated water deficit (WD) is known to improve wine grapes by reducing the vine growth (without affecting fruit yield) and boosting sugar content (Keller et al. 2008). On the other hand, irregular rainfall during the summer can lead to drought-associated damage of fruit developmental process and alter fruit metabolism (Downey et al., 2006; Tarara et al., 2008; Chalmers et al., 792). In areas undergoing desertification, WD is associated with high temperatures. This WD/high temperature synergism can limit the areas of grape cultivation and can damage yields and fruit quality. Grapes and wine are the major source of stilbenes in human nutrition, and multiple stilbene-derived compounds, including isomers, polymers and glycosylated forms, have also been characterized in grapes (Jeandet et al., 2002; Halls and Yu, 2008). Heterologous expression of stilbenesynthase (STS) in a variety of plants has led to an enhanced resistance to pathogens, but in others the association has not been proven (Kobayashi et al., 2000; Soleas et al., 1995). Tomato transgenic plants harboring a grape STS had increased levels of resveratrol, ascorbate, and glutathione at the expense of the anthocyanin pathways (Giovinazzo et al. 2005), further emphasizing the intermingled relation among secondary metabolic pathways. Stilbenes are are induced in green and fleshy parts of the berries by biotic and abiotic elicitors (Chong et al., 2009). As is the case for other classes of secondary metabolites, the biosynthesis of stilbenes is not very well understood, but it is known to be under tight spatial and temporal control, which limits the availability of these compounds from plant sources. Only very few studies have attempted to analyze the effects of different environmental components on stilbene accumulation (Jeandet et al., 1995; Martinez-Ortega et al., 2000). Targeted analyses have generally shown higher levels of resveratrol in the grape skin (induced), in seeded varieties, in varieties of wine grapes, and in dark-skinned varieties (Gatto et al., 2008; summarized by Bavaresco et al., 2009). Yet, the effect of the grape variety and the rootstock on stilbene metabolism has not yet been thoroughly investigated (Bavaresco et al., 2009). The study identified a link between vine hydraulic behavior and physiology of stress with the leaf metabolism, which the PIs believe can eventually lead to the modifications identified in the developing berries that interested the polyphenol metabolism and its regulation during development and under stress. Implications are discussed below.
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