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Journal articles on the topic 'Marginal Structural Cox models'

Author: Grafiati

Published: 10 March 2023

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1

Ali, R. Ayesha, M. Adnan Ali, and Zhe Wei. "On computing standard errors for marginal structural Cox models." Lifetime Data Analysis 20, no. 1 (2013): 106–31. http://dx.doi.org/10.1007/s10985-013-9255-7.

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Enders, Dirk, Susanne Engel, Roland Linder, and Iris Pigeot. "Robust versus consistent variance estimators in marginal structural Cox models." Statistics in Medicine 37, no. 24 (2018): 3455–70. http://dx.doi.org/10.1002/sim.7823.

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Xiao, Yongling, Erica E. M. Moodie, and Michal Abrahamowicz. "Comparison of Approaches to Weight Truncation for Marginal Structural Cox Models." Epidemiologic Methods 2, no. 1 (2013): 1–20. http://dx.doi.org/10.1515/em-2012-0006.

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Westreich, D., S. R. Cole, P. C. Tien, et al. "Time Scale and Adjusted Survival Curves for Marginal Structural Cox Models." American Journal of Epidemiology 171, no. 6 (2010): 691–700. http://dx.doi.org/10.1093/aje/kwp418.

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Karim, Mohammad Ehsanul, John Petkau, Paul Gustafson, Robert W. Platt, and Helen Tremlett. "Comparison of statistical approaches dealing with time-dependent confounding in drug effectiveness studies." Statistical Methods in Medical Research 27, no. 6 (2016): 1709–22. http://dx.doi.org/10.1177/0962280216668554.

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In longitudinal studies, if the time-dependent covariates are affected by the past treatment, time-dependent confounding may be present. For a time-to-event response, marginal structural Cox models are frequently used to deal with such confounding. To avoid some of the problems of fitting marginal structural Cox model, the sequential Cox approach has been suggested as an alternative. Although the estimation mechanisms are different, both approaches claim to estimate the causal effect of treatment by appropriately adjusting for time-dependent confounding. We carry out simulation studies to asse

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Westreich, Daniel, Stephen R. Cole, Enrique F. Schisterman, and Robert W. Platt. "A simulation study of finite-sample properties of marginal structural Cox proportional hazards models." Statistics in Medicine 31, no. 19 (2012): 2098–109. http://dx.doi.org/10.1002/sim.5317.

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Burne, Rebecca M., and Michal Abrahamowicz. "Adjustment for time-dependent unmeasured confounders in marginal structural Cox models using validation sample data." Statistical Methods in Medical Research 28, no. 2 (2017): 357–71. http://dx.doi.org/10.1177/0962280217726800.

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Large databases used in observational studies of drug safety often lack information on important confounders. The resulting unmeasured confounding bias may be avoided by using additional confounder information, frequently available in smaller clinical “validation samples”. Yet, no existing method that uses such validation samples is able to deal with unmeasured time-varying variables acting as both confounders and possible mediators of the treatment effect. We propose and compare alternative methods which control for confounders measured only in a validation sample within marginal structural C

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Bruneau, Pierre, Fahim Ashkar, and Bernard Bobée. "SMPLNORM : Un modèle simple pour obtenir les probabilités conjointes de deux débits et le niveau qui en dépend." Canadian Journal of Civil Engineering 21, no. 5 (1994): 883–95. http://dx.doi.org/10.1139/l94-094.

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Most bivariate models assume the same type of marginal distribution, with two parameters, for two variables (gamma, type I extreme values, and so forth). The disadvantage of these models is that it is often difficult to make adjustments for observed flows. This study shows the application flexibility of a program that calculates the joint probability of two variables, Q1, and Q2, with marginal distributions that have three parameters. The program can also provide the probability of nonexceedence of a third variable, H, mathematically related to the first two variables. Two applications are dis

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Santacatterina, Michele, Celia García‐Pareja, Rino Bellocco, Anders Sönnerborg, Anna Mia Ekström, and Matteo Bottai. "Optimal probability weights for estimating causal effects of time‐varying treatments with marginal structural Cox models." Statistics in Medicine 38, no. 10 (2018): 1891–902. http://dx.doi.org/10.1002/sim.8080.

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Madden, Jamie M., Finbarr P. Leacy, Lina Zgaga, and Kathleen Bennett. "Fitting Marginal Structural and G-Estimation Models Under Complex Treatment Patterns: Investigating the Association Between De Novo Vitamin D Supplement Use After Breast Cancer Diagnosis and All-Cause Mortality Using Linked Pharmacy Claim and Registry Data." American Journal of Epidemiology 189, no. 3 (2019): 224–34. http://dx.doi.org/10.1093/aje/kwz243.

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Abstract Studies have shown that accounting for time-varying confounding through time-dependent Cox proportional hazards models may provide biased estimates of the causal effect of treatment when the confounder is also a mediator. We explore 2 alternative approaches to addressing this problem while examining the association between vitamin D supplementation initiated after breast cancer diagnosis and all-cause mortality. Women aged 50–80 years were identified in the National Cancer Registry Ireland (n = 5,417) between 2001 and 2011. Vitamin D use was identified from linked prescription data (n

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Karim, Mohammad Ehsanul, Paul Gustafson, John Petkau та ін. "Marginal Structural Cox Models for Estimating the Association Between β-Interferon Exposure and Disease Progression in a Multiple Sclerosis Cohort". American Journal of Epidemiology 180, № 2 (2014): 160–71. http://dx.doi.org/10.1093/aje/kwu125.

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Karim, Mohammad Ehsanul, John Petkau, Paul Gustafson, Helen Tremlett, and The Beams Study Group. "On the application of statistical learning approaches to construct inverse probability weights in marginal structural Cox models: Hedging against weight-model misspecification." Communications in Statistics - Simulation and Computation 46, no. 10 (2017): 7668–97. http://dx.doi.org/10.1080/03610918.2016.1248574.

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Terrier, Benjamin, Evguenia Krastinova, Isabelle Marie, et al. "Management of noninfectious mixed cryoglobulinemia vasculitis: data from 242 cases included in the CryoVas survey." Blood 119, no. 25 (2012): 5996–6004. http://dx.doi.org/10.1182/blood-2011-12-396028.

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Abstract Data on the clinical spectrum and therapeutic management of noninfectious mixed cryoglobulinemia vasculitis (CryoVas) in the era of hepatitis C virus screening are lacking. We analyzed data from 242 patients with noninfectious mixed CryoVas included in the French multicenter CryoVas survey. Baseline manifestations were purpura (75%), peripheral neuropathy (52%), arthralgia or arthritis (44%), glomerulonephritis (35%), cutaneous ulcers (16%), and cutaneous necrosis (14%). A connective tissue disease was diagnosed in 30% and B-cell non-Hodgkin lymphoma in 22%, whereas the CryoVas was co

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Onozawa, Satoshi, Tomomi Kimura, Yuichiro Ito, and Tadao Akizawa. "Estimating the causal effect of transient anemia status on renal and cardiovascular outcomes in community-dwelling patients in Japan at the beginning of impaired renal function using marginal structural modeling." Clinical and Experimental Nephrology 26, no. 2 (2021): 178–89. http://dx.doi.org/10.1007/s10157-021-02137-1.

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Abstract Background Anemia status may be transient. Causal associations between changes in anemia status over time and adverse outcome development are not well characterized in community-dwelling subjects at the beginning of impaired kidney function. Methods This retrospective cohort study used annual health checkup and medical and pharmacy claims data from the JMDC between January 2005 and June 2019. Community-dwelling subjects in Japan with a pre-index estimated glomerular filtration rate (eGFR) ≥ 60 mL/min/1.73 m2 followed by a subsequent eGFR < 60 mL/min/1.73 m2 (index) were included. T

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Pons, Marion, Sylvie Chevret, Karine Briot, et al. "Evaluation of long-term TNFi effectiveness after a first switch in early axial spondyloarthritis considering time-varying prescription bias: an inverse-probability weighting analysis of the DESIR cohort." RMD Open 8, no. 1 (2022): e001846. http://dx.doi.org/10.1136/rmdopen-2021-001846.

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ObjectiveTo evaluate long-term effectiveness of tumour necrosis factor inhibitor (TNFi) after a first switch, and their associated factors in an early axial spondyloarthritis (axSpA) population, considering time-varying prescription bias.MethodsObservational prospective cohort (DEvenir des Spondylarthropathies Indifférenciées Récentes) with 5 years of follow-up, including 708 TNFi-naïve patients with early axSpA. Long-term effectiveness of TNFi after a first switch (ASAS40 response after at least 2 visits under treatment) were estimated using marginal structural models (implementing inverse-pr

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Severus, W. E., I. A. Lipkovich, R. W. Licht, et al. "In search of optimal lithium levels and olanzapine doses in the long-term treatment of bipolar I disorder. A post-hoc analysis of the maintenance study by Tohen et al. 2005." European Psychiatry 25, no. 8 (2010): 443–49. http://dx.doi.org/10.1016/j.eurpsy.2009.10.009.

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AbstractPurposeThe aim of this study was to investigate whether lower lithium levels (LoLi) or olanzapine doses (LoOL) are risk factors for future mood episodes in patients with bipolar I disorder.MethodsA post-hoc analysis of the olanzapine-lithium-maintenance study [31] was performed using proportional hazards Cox regression models and marginal structural models (MSMs), adjusting for non-random assignments of dose during treatment.ResultsThe LoLi group (< 0.6 mmol/L) had a significantly increased risk of manic/mixed (hazard ratio [HR] = 1.96, p = 0.042), but not depressive (HR = 2.11, p =

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Yuan, Shiqi, Chong Chen, Fengshuo Xu, et al. "Antithrombotic Therapy Improves ICU Mortality of Septic Patients with Peripheral Vascular Disease." International Journal of Clinical Practice 2022 (March 16, 2022): 1–6. http://dx.doi.org/10.1155/2022/1288535.

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Objective. The effectiveness of antithrombotic drugs for treating sepsis is controversial. Here, we explore the association between antithrombotic therapy and intensive care unit (ICU) mortality for septic patients with peripheral vascular disease. Methods. This retrospective cohort study uses data from the Medical Information Mart for Intensive Care (MIMIC)-III database. Kaplan–Meier survival analyses were used to examine mortality among different groups. Cox regression and marginal structural Cox models (MSCMs) were used to adjust for confounding factors. Main Results. The final cohort from

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Singh, N., A. Peterson, A. Baraff, et al. "POS1434 USE OF BIOLOGIC OR TARGETED SYNTHETIC DISEASE MODIFYING ANTI-RHEUMATIC DRUGS AND THE RISK OF LYMPHOMA IN RHEUMATOID ARTHRITIS." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1060.2–1061. http://dx.doi.org/10.1136/annrheumdis-2022-eular.3408.

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BackgroundEpidemiologic studies suggest that disease duration and degree of inflammatory activity of rheumatoid arthritis (RA) contribute to lymphoma development (1). Whether the decrease in inflammatory burden seen with use of biologic or targeted synthetic disease modifying anti-rheumatic drugs (bDMARDs or tsDMARDs) translates into a lower risk of lymphoma in RA needs to be studied.ObjectivesThe objective of our study was to examine the effect of administration of b/tsDMARDS on the incidence of lymphoma relative to conventional synthetic DMARDs (csDMARDs) in an inception cohort of Veterans w

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Szabo, Shelagh M., Katherine Gooch, Carol Schermer, et al. "Association between cumulative anticholinergic burden and falls and fractures in patients with overactive bladder: US-based retrospective cohort study." BMJ Open 9, no. 5 (2019): e026391. http://dx.doi.org/10.1136/bmjopen-2018-026391.

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ObjectiveTo estimate the association between cumulative anticholinergic burden and falls and fractures in patients with overactive bladder (OAB).DesignA retrospective claims-based study (2007–2015) of patients with OAB; outcomes from a subset were contrasted to a non-OAB comparison.SettingUnited States, commercially and Medicare-insured population.Participants154 432 adults with OAB and 86 966 adults without OAB, mean age of 56 years, and 67.9% women.Main outcome measuresCumulative anticholinergic burden, a unitless value representing exposure over time, was estimated over the 12 months pre-in

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Neugebauer, Romain, Malini Chandra, Antonio Paredes, David J. Graham, Carolyn McCloskey, and Alan S. Go. "A Marginal Structural Modeling Approach with Super Learning for a Study on Oral Bisphosphonate Therapy and Atrial Fibrillation." Journal of Causal Inference 1, no. 1 (2013): 21–50. http://dx.doi.org/10.1515/jci-2012-0003.

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AbstractPurpose: Observational studies designed to investigate the safety of a drug in a postmarketing setting typically aim to examine rare and non-acute adverse effects in a population that is not restricted to particular patient subgroups for which the therapy, typically a drug, was originally approved. Large healthcare databases and, in particular, rich electronic medical record (EMR) databases, are well suited for the conduct of these safety studies since they can provide detailed longitudinal information on drug exposure, confounders, and outcomes for large and representative samples of

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THAMER, MAE, MIGUEL A. HERNÁN, YI ZHANG, DENNIS COTTER, and MICHELLE PETRI. "Prednisone, Lupus Activity, and Permanent Organ Damage." Journal of Rheumatology 36, no. 3 (2009): 560–64. http://dx.doi.org/10.3899/jrheum.080828.

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Objective.To estimate the effect of corticosteroids (prednisone dose) on permanent organ damage among persons with systemic lupus erythematosus (SLE).Methods.We identified 525 patients with incident SLE in the Hopkins Lupus Cohort. At each visit, clinical activity indices, laboratory data, and treatment were recorded. The study population was followed from the month after the first visit until June 29, 2006, or attainment of irreversible organ damage, death, loss to follow-up, or receipt of pulse methylprednisolone therapy. We estimated the effect of cumulative average dose of prednisone on or

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Bansal, Nisha, Dawei Xie, Daohang Sha, et al. "Cardiovascular Events after New-Onset Atrial Fibrillation in Adults with CKD: Results from the Chronic Renal Insufficiency Cohort (CRIC) Study." Journal of the American Society of Nephrology 29, no. 12 (2018): 2859–69. http://dx.doi.org/10.1681/asn.2018050514.

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BackgroundAtrial fibrillation (AF), the most common sustained arrhythmia in CKD, is associated with poor clinical outcomes in both patients without CKD and patients with dialysis-treated ESRD. However, less is known about AF-associated outcomes in patients with CKD who do not require dialysis.MethodsTo prospectively examine the association of new-onset AF with subsequent risks of cardiovascular disease events and death among adults with CKD, we studied participants enrolled in the Chronic Renal Insufficiency Cohort Study who did not have AF at baseline. Outcomes included heart failure, myocard

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Regal, Ronald R., and Ernest B. Hook. "Marginal versus conditional versus ‘structural source’ models: a rationale for an alternative to log-linear methods for capture-recapture estimates." Statistics in Medicine 17, no. 1 (1998): 69–74. http://dx.doi.org/10.1002/(sici)1097-0258(19980115)17:1<69::aid-sim729>3.0.co;2-q.

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Resche-Rigon, Matthieu, Marie Robin, Regis Peffault de Latour, Sylvie Chevret, and Gerard P. Socie. "Estimating the Causal Effect of Some Exposure From Nonrandomized Studies: The Example of Reduced Intensity Conditioning (RIC) in Hematological Diseases." Blood 114, no. 22 (2009): 3365. http://dx.doi.org/10.1182/blood.v114.22.3365.3365.

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Abstract Abstract 3365 Poster Board III-253 Introduction: Although allogeneic SCT with RIC has now gained wide acceptance, its eventual benefit again non-transplant approach is largely unknown (outside the setting of large randomized trials). When evaluating the impact on survival of reduced intensity conditioning in malignant hematological diseases, standard estimations based on Cox regression from observational databases could be biased because they ignore covariates that confound treatment decision. In this setting, we applied and compared two different statistical methods that were develop

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Thomas, Emma G., Matthew J. Spittal, Faye S. Taxman, Cheneal Puljević, Edward B. Heffernan, and Stuart A. Kinner. "Association between contact with mental health and substance use services and reincarceration after release from prison." PLOS ONE 17, no. 9 (2022): e0272870. http://dx.doi.org/10.1371/journal.pone.0272870.

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Objective People released from prison who experience mental health and substance use problems are at high risk of reincarceration. This study aimed to examine the association between contact with mental health and substance use treatment services, and reincarceration, among adults released from prison. Methods Pre-release survey data from 1,115 adults released from prisons in Queensland, Australia were linked with administrative health and correctional records covering a median of 787 days post-release. We constructed marginal structural Cox proportional hazards models, adjusting for pre-relea

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Munir, Muhammad Bilal, Patrick Hlavacek, Allison Keshishian, et al. "Contemporary clinical and economic outcomes among oral anticoagulant treated and untreated elderly patients with atrial fibrillation: Insights from the United States Medicare database." PLOS ONE 17, no. 2 (2022): e0263903. http://dx.doi.org/10.1371/journal.pone.0263903.

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Background Oral anticoagulants (OACs) mitigate the risk of stroke in atrial fibrillation (AF) patients. Objective Elderly AF patients who were treated with OACs (apixaban, dabigatran, edoxaban, rivaroxaban, or warfarin) were compared against AF patients who were not treated with OACs with respect to their clinical and economic outcomes. Methods Newly diagnosed AF patients were identified between January 2013 and December 2017 in the Medicare database. Evidence of an OAC treatment claim on or after the first AF diagnosis was used to classify patients into treatment-defined cohorts, and these co

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Jansz, Thijs T., Marlies Noordzij, Anneke Kramer, et al. "Survival of patients treated with extended-hours haemodialysis in Europe: an analysis of the ERA-EDTA Registry." Nephrology Dialysis Transplantation 35, no. 3 (2019): 488–95. http://dx.doi.org/10.1093/ndt/gfz208.

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Abstract Background Previous US studies have indicated that haemodialysis with ≥6-h sessions [extended-hours haemodialysis (EHD)] may improve patient survival. However, patient characteristics and treatment practices vary between the USA and Europe. We therefore investigated the effect of EHD three times weekly on survival compared with conventional haemodialysis (CHD) among European patients. Methods We included patients who were treated with haemodialysis between 2010 and 2017 from eight countries providing data to the European Renal Association–European Dialysis and Transplant Association R

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Memel, Zoe N., Jenny J. Lee, Andrea S. Foulkes, Raymond T. Chung, Tanayott Thaweethai, and Patricia P. Bloom. "Association of Statins and 28-Day Mortality Rates in Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 Infection." Journal of Infectious Diseases 225, no. 1 (2021): 19–29. http://dx.doi.org/10.1093/infdis/jiab539.

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Abstract Background Statins may be protective in severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 infection. The aim of the current study was to evaluate the effect of in-hospital statin use on 28-day mortality rates and intensive care unit (ICU) admission among patients with SARS-CoV-2, stratified into 4 groups: those who used statins before hospitalization (treatment continued or discontinued in the hospital) and those who did not (treatment newly initiated in the hospital or never initiated). Methods In a cohort study of 1179 patients with SARS-CoV-2, record review was used to ass

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Kirchgesner, Julien, Nynne Nyboe Andersen, Fabrice Carrat, Tine Jess, and Laurent Beaugerie. "Risk of acute arterial events associated with treatment of inflammatory bowel diseases: nationwide French cohort study." Gut 69, no. 5 (2019): 852–58. http://dx.doi.org/10.1136/gutjnl-2019-318932.

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ObjectivePatients with IBD are at increased risk of acute arterial events. Antitumour necrosis factor (TNF) agents and thiopurines may, via their anti-inflammatory properties, lower the risk of acute arterial events. The aim of this study was to assess the impact of thiopurines and anti-TNFs on the risk of acute arterial events in patients with IBD.DesignPatients aged 18 years or older and affiliated to the French national health insurance with a diagnosis of IBD were followed up from 1 April 2010 until 31 December 2014. The risks of acute arterial events (including ischaemic heart disease, ce

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Chirgwin, Jacquie H., Anita Giobbie-Hurder, Alan S. Coates, et al. "Treatment Adherence and Its Impact on Disease-Free Survival in the Breast International Group 1-98 Trial of Tamoxifen and Letrozole, Alone and in Sequence." Journal of Clinical Oncology 34, no. 21 (2016): 2452–59. http://dx.doi.org/10.1200/jco.2015.63.8619.

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Purpose To investigate adherence to endocrine treatment and its relationship with disease-free survival (DFS) in the Breast International Group (BIG) 1-98 clinical trial. Methods The BIG 1-98 trial is a double-blind trial that randomly assigned 6,193 postmenopausal women with hormone receptor–positive early breast cancer in the four-arm option to 5 years of tamoxifen (Tam), letrozole (Let), or the agents in sequence (Let-Tam, Tam-Let). This analysis included 6,144 women who received at least one dose of study treatment. Conditional landmark analyses and marginal structural Cox proportional haz

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Hoque, M. R., A. Aviña, M. De Vera, Y. Qian, J. Esdaile, and H. Xie. "SAT0175 IMPACT OF ANTIMALARIAL ADHERENCE ON MORTALITY AMONG PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS: A POPULATION-BASED COHORT STUDY." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1029.1–1029. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3340.

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Background:Evidence has consistently shown that adherence to AM is poor in systemic lupus erythematosus (SLE) patients. However, data on the impact of adherence to AM on mortality is scarce.Objectives:To assess the effect of AM adherence on all-cause mortality in SLE patients from the general population.Methods:This study used administrative databases from British Columbia, Canada. We created an incident SLE cohort between January 01, 1997, and March 31, 2015, using the physician billing data and a 7-year washout period. The inclusion criteria were at least two physician visits, at least two m

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Marathe, Gayatri, Erica E. M. Moodie, Marie-Josée Brouillette, et al. "Depressive symptoms are no longer a barrier to HCV treatment initiation in the HIV–HCV co-infected population in Canada." Antiviral Therapy 27, no. 1 (2022): 135965352110676. http://dx.doi.org/10.1177/13596535211067610.

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Background Psychiatric illness was a major barrier for HCV treatment during the Interferon (IFN) treatment era due to neuropsychiatric side effects. While direct acting antivirals (DAA) are better tolerated, patient-level barriers persist. We aimed to assess the effect of depressive symptoms on time to HCV treatment initiation among HIV–HCV co-infected persons during the IFN (2003–2011) and second-generation DAA (2013–2020) eras. Methods We used data from the Canadian Co-infection Cohort, a multicentre prospective cohort, and its associated sub-study on Food Security (FS). We predicted Center

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Cohen, Seth M., Hui-Jie Lee, David A. Leiman, Nelson Roy, and Stephanie Misono. "Associations between Community-Acquired Pneumonia and Proton Pump Inhibitors in the Laryngeal/Voice-Disordered Population." Otolaryngology–Head and Neck Surgery 160, no. 3 (2018): 519–25. http://dx.doi.org/10.1177/0194599818811292.

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Objectives To examine the relationship between community-acquired pneumonia (CAP) and proton pump inhibitor (PPI) treatment among patients with laryngeal/voice disorders. Study Design Retrospective cohort analysis. Setting Large national administrative US claims database. Subjects and Methods Patients were included if they were ≥18 years old; had outpatient treatment for a laryngeal/voice disorder from January 1, 2010, to December 31, 2014 (per International Classification of Diseases, Ninth Revision, Clinical Modification codes); had 12 months of continuous enrollment prior to the index date

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Veluswamy, Rajwanth, Jiayi Ji, Liangyuan Hu, Xiaoliang Wang, Cardinale B. Smith, and Minal Kale. "Effect of first-line pembrolizumab treatment in individuals with advanced non-small cell lung cancer and poor performance status." Journal of Clinical Oncology 39, no. 15_suppl (2021): e18796-e18796. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e18796.

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e18796 Background: There is limited evidence supporting the optimal use of immune checkpoint inhibitors (ICIs) in NSCLC patients with poor performance status (PS), as clinical trials exclude these patients. In this study, we use real-world oncology data to determine the impact of first line pembrolizumab vs. no treatment in high PD(L)-1 expressing cancers in individuals with advanced NSCLC and ECOG PS ≥2. Methods: We performed a retrospective cohort study of patients with advanced NSCLC with ECOG PS ≥2 between 09/01/2014 and 02/18/2020, using the nationwide Flatiron Health electronic health re

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De Stavola, Bianca L., and Rhian M. Daniel. "Marginal Structural Models." Epidemiology 23, no. 2 (2012): 233–37. http://dx.doi.org/10.1097/ede.0b013e318245847e.

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Kennedy, Mary Clare, Alexis Crabtree, Seonaid Nolan, et al. "Discontinuation and tapering of prescribed opioids and risk of overdose among people on long-term opioid therapy for pain with and without opioid use disorder in British Columbia, Canada: A retrospective cohort study." PLOS Medicine 19, no. 12 (2022): e1004123. http://dx.doi.org/10.1371/journal.pmed.1004123.

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Background The overdose crisis in North America has prompted system-level efforts to restrict opioid prescribing for chronic pain. However, little is known about how discontinuing or tapering prescribed opioids for chronic pain shapes overdose risk, including possible differential effects among people with and without concurrent opioid use disorder (OUD). We examined associations between discontinuation and tapering of prescribed opioids and risk of overdose among people on long-term opioid therapy for pain, stratified by diagnosed OUD and prescribed opioid agonist therapy (OAT) status. Method

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Xing, Yihan, Tan Aditya Dwi Santoso, and Yucong Ma. "Technical–Economic Feasibility Analysis of Subsea Shuttle Tanker." Journal of Marine Science and Engineering 10, no. 1 (2021): 20. http://dx.doi.org/10.3390/jmse10010020.

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This paper presents the technical and economic feasibility analysis of the subsea shuttle tanker (SST). The SST is proposed as an alternative to subsea pipelines and surface tankers with the primary purpose of transporting CO2 autonomously underwater from onshore facilities to subsea wells for direct injection at marginal subsea fields. In contrast to highly weather-dependent surface tanker operations, the SST can operate in any condition underwater. The technical–economic analysis is performed in two steps. First, the SST’s technical feasibility is evaluated by investigating designs with lowe

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Longo, Cristina, Gillian Bartlett, Tibor Schuster, Francine M. Ducharme, Brenda MacGibbon, and Tracie A. Barnett. "Influence of weight status in the response to Step-2 maintenance therapies in children with asthma." BMJ Open Respiratory Research 6, no. 1 (2019): e000401. http://dx.doi.org/10.1136/bmjresp-2019-000401.

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IntroductionOverweight children with asthma may display impaired response to inhaled corticosteroids (ICS), possibly due to non-eosinophilic inflammation or weight-related lung compression; these mechanisms may differentially affect response to ICS and leukotriene receptor antagonists (LTRAs). We assessed whether weight status modified the response to low-dose ICS and LTRA Step-2 monotherapy.MethodsA historical cohort study from clinical data linked to administrative databases was conducted among children aged 2–18 years with specialist-diagnosed asthma who were initiating or continuing a Step

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Honda, Toshio. "Estimation in additive cox models by marginal integration." Annals of the Institute of Statistical Mathematics 57, no. 3 (2005): 403–23. http://dx.doi.org/10.1007/bf02509232.

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Liu, Shao-Hsien, Stavroula A. Chrysanthopoulou, Qiuzhi Chang, Jacob N. Hunnicutt, and Kate L. Lapane. "Missing Data in Marginal Structural Models." Medical Care 57, no. 3 (2019): 237–43. http://dx.doi.org/10.1097/mlr.0000000000001063.

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Bryan, J. "Analysis of longitudinal marginal structural models." Biostatistics 5, no. 3 (2004): 361–80. http://dx.doi.org/10.1093/biostatistics/kxg041.

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Smith, Madison M., Marika Holland, and Bonnie Light. "Arctic sea ice sensitivity to lateral melting representation in a coupled climate model." Cryosphere 16, no. 2 (2022): 419–34. http://dx.doi.org/10.5194/tc-16-419-2022.

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Abstract. The melting of sea ice floes from the edges (lateral melting) results in open-water formation and subsequently increases absorption of solar shortwave energy. However, lateral melt plays a small role in the sea ice mass budget in both hemispheres in most climate models. This is likely influenced by the simple parameterization of lateral melting in sea ice models that are constrained by limited observations. Here we use a coupled climate model (CESM2.0) to assess the sensitivity of modeled sea ice state to the lateral melt parameterization in preindustrial and 2×CO2 runs. The runs exp

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Saarela, Olli, David A. Stephens, Erica E. M. Moodie, and Marina B. Klein. "On Bayesian estimation of marginal structural models." Biometrics 71, no. 2 (2015): 279–88. http://dx.doi.org/10.1111/biom.12269.

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VanderWeele, Tyler J., Stijn Vansteelandt, and James M. Robins. "Marginal Structural Models for Sufficient Cause Interactions." American Journal of Epidemiology 171, no. 4 (2010): 506–14. http://dx.doi.org/10.1093/aje/kwp396.

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Chiba, Yasutaka, Kenichi Azuma, and Jiro Okumura. "Marginal Structural Models for Estimating Effect Modification." Annals of Epidemiology 19, no. 5 (2009): 298–303. http://dx.doi.org/10.1016/j.annepidem.2009.01.025.

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Vansteelandt, S., K. Mertens, C. Suetens, and E. Goetghebeur. "Marginal structural models for partial exposure regimes." Biostatistics 10, no. 1 (2008): 46–59. http://dx.doi.org/10.1093/biostatistics/kxn012.

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Platt, Robert W., M. Alan Brookhart, Stephen R. Cole, Daniel Westreich, and Enrique F. Schisterman. "An information criterion for marginal structural models." Statistics in Medicine 32, no. 8 (2012): 1383–93. http://dx.doi.org/10.1002/sim.5599.

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Medialdea, Adriana, José Miguel Angulo, and Jorge Mateu. "Structural Complexity and Informational Transfer in Spatial Log-Gaussian Cox Processes." Entropy 23, no. 9 (2021): 1135. http://dx.doi.org/10.3390/e23091135.

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The doubly stochastic mechanism generating the realizations of spatial log-Gaussian Cox processes is empirically assessed in terms of generalized entropy, divergence and complexity measures. The aim is to characterize the contribution to stochasticity from the two phases involved, in relation to the transfer of information from the intensity field to the resulting point pattern, as well as regarding their marginal random structure. A number of scenarios are explored regarding the Matérn model for the covariance of the underlying log-intensity random field. Sensitivity with respect to varying v

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Sato, Tosiya, and Yutaka Matsuyama. "Marginal Structural Models as a Tool for Standardization." Epidemiology 14, no. 6 (2003): 680–86. http://dx.doi.org/10.1097/01.ede.0000081989.82616.7d.

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Tan, Zhiqiang. "Marginal and Nested Structural Models Using Instrumental Variables." Journal of the American Statistical Association 105, no. 489 (2010): 157–69. http://dx.doi.org/10.1198/jasa.2009.tm08299.

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