Journal articles on the topic 'Mappa logistica'
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Caroline Cabral da Fonseca, Emmily, Eriton Carlos Martins Barreiros, Paulo Vitor dos Santos Gonçalves, André Cristiano Silva Melo, and Denilson Ricardo de Lucena Nunes. "Proposal for processes map of post-consumption reverse logistics under the perspective of the national solid waste policy." Revista Gestão da Produção Operações e Sistemas 12, no. 1 (March 1, 2017): 83–100. http://dx.doi.org/10.15675/gepros.v12i1.1601.
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Spyropoulos, Alex C., Dimitrios Giannis, Jessica Cohen, Suja John, Anne Myrka, Damian Inlall, Michael Qiu, Saydi Akgul, Roger J. Hyman, and Jason J. Wang. "Implementation of the Management of Anticoagulation in the Periprocedural Period App Into an Electronic Health Record: A Prospective Cohort Study." Clinical and Applied Thrombosis/Hemostasis 26 (January 1, 2020): 107602962092591. http://dx.doi.org/10.1177/1076029620925910.
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Appropriate perioperative management of patients on chronic oral anticoagulation (OAC)—including warfarin and the direct oral anticoagulants—is a poorly defined yet important clinical issue with potentially severe consequences in the postoperative period. We sought to prospectively evaluate the effect of the Management of Anticoagulation in the Periprocedural Period (MAPPP) mobile app as a clinical decision tool in the management of patients on chronic OAC undergoing elective procedures or surgeries. Between January 1, 2018, and January 31, 2019, 642 patients treated in our health system were included. Eligible patients met the following criteria: age >18 years old, creatinine clearance ≥15 mL/min, and on chronic OAC with adequate information regarding baseline characteristics. Our study outcome was patient’s emergency department (ED) visits within 30 days postprocedure. The MAPPP app was integrated into the electronic health record (EHR), and the end user was free to accept or decline recommended evidence-based perioperative anticoagulation management guidance. Analysis revealed that acceptance was more common in younger patients ( P = .0137), patients on oral anticoagulants other than warfarin ( P < .0001), and patients undergoing increased bleeding risk procedures ( P = .0068). Acceptance of the MAPPP app recommendation was significantly associated with fewer ED visits (acceptance group: 4.0% vs rejection group: 8.3%, P = .0205). Logistic regression showed that intervention acceptance and female gender were significantly associated with fewer—while age ≥80 with more—30-day ED visits. Our findings indicate that newer technologies, such as the MAPPP app, integrated into clinical EHR workflow, can significantly augment evidence-based perioperative anticoagulation management and potentially result in a reduction of adverse outcomes.
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Mafra, Renata Cristina, Mayara Maezano Faita Pinheiro, Rejane Ennes Cicerelli, Lucas Prado Osco, Marcelo Rodrigo Alves, and Ana Paula Marques Ramos. "Validação de mapa de vulnerabilidade a erosão por aprendizagem de máquina." Revista Brasileira de Geografia Física 13, no. 2 (April 7, 2020): 564. http://dx.doi.org/10.26848/rbgf.v13.2.p564-575.
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O processo erosivo é um fenômeno que acontece devido às condições climáticas ou uso inadequado da terra. O mapeamento dos níveis de vulnerabilidade à erosão de uma área pode ocorrer usando diferentes modelos de inferência geográfica. No entanto, definir o método apropriado é ainda uma questão a ser respondida. Este trabalho apresenta uma abordagem de validação de mapa de vulnerabilidade à erosão elaborado por diferentes métodos de inferência. Como estudo de caso, adotou-se uma bacia hidrográfica e considerou-se os seguintes critérios: geomorfologia, pedologia, declividade, densidade de drenagem e cobertura da terra. Dentre os métodos testados tem-se: Combinação Linear Ponderada (CLP) e três operadores Fuzzy: soma algébrica, produto algébrico e gamma, variando o expoente “γ” entre os valores 0,4; 0,6 e 0,8. Os pesos dos critérios foram definidos com base no Processo Analítico Hierárquico. A validação dos mapas ocorreu usando 1902 pontos, sendo 951 pontos de erosão na área, definidos com base em imagens do Google Earth Pro, e 951 pontos sem erosão, gerados aleatoriamente no QGIS 3.8. O modelo de regressão logística foi usado parar comparar o desempenho de cada mapa ao apontar as áreas com maior e menor grau de vulnerabilidade. A melhor modelagem foi alcançada com o operador Fuzzy gamma quando parametrizado com γ = 0,6. Embora o CLP seja a abordagem recorrente em estudos ambientais envolvendo inferência geográfica, nossos resultados demostram que outros operadores podem produzir resultados mais próximos aos encontrados com a realidade observada em campo. Machine learning erosion and vulnerability map validation A B S T R A C TErosion is a natural phenomenon that happens in all ecosystems, whether due to weather conditions or inappropriate land use. Mapping the erosion vulnerability levels of an area can occur using different methods of geographic inference. However, defining the appropriate method is still a question to be answered. This paper presents an erosion vulnerability map validation approach elaborated by different inference methods. As a case study, a watershed was adopted and the following criteria were considered: geomorphology, pedology, slope, drainage density and land cover. Among the tested methods are: Weighted Linear Combination (WLC) and three Fuzzy operators: algebraic sum, algebraic product and gamma, varying the exponent “γ” between the values 0.4; 0.6 and 0.8. The weights of the criteria were defined based on the Hierarchical Analytical Process. The validation of the maps took place using 1902 points, with 951 erosion points in the area defined based on Google Earth Pro images and 951 points without erosion randomly generated in QGIS 3.8. The logistic regression model was used to compare the performance of each map by pointing out the areas with the highest and lowest degree of vulnerability. The best modeling was achieved with the Fuzzy gamma operator when parameterized with γ = 0.6. Although WLC is the recurring approach in environmental studies involving geographic inference, our results show that other operators can produce results closer to those encountered with the reality observed in the field.Keywords: Geographical inference; multicriteria analysis; data validation; environmental impact.
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Cheng, Jun, Chengming Fan, Mi Tang, Yusheng Shu, and Jinfu Yang. "Initial Research on Postoperative Management of Tetralogy of Fallot with Major Aortopulmonary Collaterals." Cardiology 134, no. 4 (2016): 406–10. http://dx.doi.org/10.1159/000445046.
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Objectives: Tetralogy of Fallot (TOF) with major aortopulmonary collaterals (MAPCA) is a well-known but always severe congenital heart disease. This study was designed to explore proper management after radical correction of TOF with MAPCA based on a hierarchical approach. Methods: The following data were collected from 39 patients planned to undergo radical correction of TOF: age, weight, number of aortopulmonary collaterals, total lumen diameter and collateral diameter-to-body weight ratio, transcatheter occlusion and cardiac catheterization findings, mechanical ventilation time, and ICU monitoring time. The patients were divided into 4 groups by collateral diameter-to-body weight ratio as follows: <0.200 mm/kg (group 1), 0.200-0.500 mm/kg (group 2), >0.500 mm/kg (group 3), and no MAPCA (group 4). Data analysis was performed using IBM SPSS Statistics software for Mac version 22.0 (SPSS Inc., Chicago, Ill., USA) with logistic regression and Fisher's exact test. Results: Most of the patients recovered well after radical correction; postoperative complications occurred in 12 patients and included bloody sputum, low cardiac output syndrome, and severe pulmonary infection that led to tracheotomy. By prolonging the mechanical ventilation time of the patients with postoperative complications, the conditions in 3 patients were improved. However, in the remaining patients, the condition worsened until transcatheter occlusions were performed. Transcatheter occlusion was performed in all 7 patients in group 3 (100%). Only 2 of the 8 patients in group 2 required transcatheter occlusion (25%), and none of the 9 patients in group 1 required transcatheter occlusion (0%). Only 1 patient (group 3) died after radical correction. The transcatheter occlusion results showed a strong association with the total lumen diameter and the collateral diameter-to-body weight ratio (p < 0.05) but no obvious association with age, weight, or the number of aortopulmonary collaterals (p > 0.05). Conclusions: Postoperative management of patients with TOF and MAPCA has great significance. To reduce the morbidity and mortality, transcatheter coil embolization or surgical ligation should be performed in patients with a collateral diameter-to-body weight ratio of at least 0.500 mm/kg. In patients with values between approximately 0.200 and 0.500 mm/kg, prolongation of mechanical ventilation should have priority over transcatheter occlusion, and for patients with values below 0.200 mm/kg no additional treatment is needed.
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Coelho, Fabrício Fernandes, and Elvio Giasson. "Comparação de métodos para mapeamento digital de solos com utilização de sistema de informação geográfica." Ciência Rural 40, no. 10 (October 1, 2010): 2099–106. http://dx.doi.org/10.1590/s0103-84782010005000156.
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Mapas pedológicos são fontes de informações primordiais para planejamento e manejo do uso do solo, porém apresentam altos custos de produção. A fim de produzir mapas de solos a partir de mapas existentes, neste trabalho, foram comparados métodos de classificação em estágio único (Regressões Logísticas Múltiplas Multinomiais e Bayes) e em estágios múltiplos (Classification and Regression Trees (CART), J48 e Logistic Model Trees (LMT)) com a utilização de sistemas de informações geográficas e de variáveis geomorfométricas para produção de mapas pedológicos com legenda original e simplificada. A base de dados foi gerenciada em aplicativo computacional ArcGis, em que as variáveis e o mapa original foram relacionados por meio de amostras de treinamento para os algoritmos. Os resultados dos algoritmos obtidos no software Weka foram implementados no ArcGis, para a confecção dos mapas. Foram geradas matrizes de erros para análise de acurácias dos mapas. As variáveis geomorfométricas de declividade, perfil e plano de curvatura, elevação e índice de umidade topográfica são aquelas que melhor explicam a distribuição espacial das classes de solo. Os métodos de classificação em estágio múltiplo apresentaram sensíveis melhoras nas acurácias globais, porém significativas melhoras nos índices Kappa. A utilização de legenda simplificada aumentou significativamente as acurácias do produtor e do usuário.
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Ahmed, W., F. Huygens, A. Goonetilleke, and T. Gardner. "Real-Time PCR Detection of Pathogenic Microorganisms in Roof-Harvested Rainwater in Southeast Queensland, Australia." Applied and Environmental Microbiology 74, no. 17 (July 11, 2008): 5490–96. http://dx.doi.org/10.1128/aem.00331-08.
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ABSTRACT In this study, the microbiological quality of roof-harvested rainwater was assessed by monitoring the concentrations of Escherichia coli, enterococci, Clostridium perfringens, and Bacteroides spp. in rainwater obtained from tanks in Southeast Queensland, Australia. Samples were also tested using real-time PCR (with SYBR Green I dye) for the presence of potential pathogenic microorganisms. Of the 27 rainwater samples tested, 17 (63%), 21 (78%), 13 (48%), and 24 (89%) were positive for E. coli, enterococci, C. perfringens, and Bacteroides spp., respectively. Of the 27 samples, 11 (41%), 7 (26%), 4 (15%), 3 (11%), and 1 (4%) were PCR positive for the Campylobacter coli ceuE gene, the Legionella pneumophila mip gene, the Aeromonas hydrophila lip gene, the Salmonella invA gene, and the Campylobacter jejuni mapA gene. Of the 21 samples tested, 4 (19%) were positive for the Giardia lamblia β-giardin gene. The binary logistic regression model indicated a positive correlation (P < 0.02) between the presence/absence of enterococci and A. hydrophila. In contrast, the presence/absence of the remaining potential pathogens did not correlate with traditional fecal indicators. The poor correlation between fecal indicators and potential pathogens suggested that fecal indicators may not be adequate to assess the microbiological quality of rainwater and consequent health risk.
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Riesgo, Henar, Angeles Castro, Sofía del Amo, Maria Jesus San Ceferino, Olatz Izaola, David Primo, Emilia Gómez Hoyos, Juan Jose López Gómez, and Daniel A. de Luis. "Prevalence of Risk of Malnutrition and Risk of Sarcopenia in a Reference Hospital for COVID-19: Relationship with Mortality." Annals of Nutrition and Metabolism 77, no. 6 (2021): 324–29. http://dx.doi.org/10.1159/000519485.
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<b><i>Introduction:</i></b> Many elderly patients with COVID-19 are at risk of malnutrition. The aim of our study was to evaluate the risk of malnutrition and sarcopenia in elderly COVID-19 patients with the R-MAPP (Remote-Malnutrition APP). <b><i>Materials and Methods:</i></b> A cross-sectional study of 337 consecutive outpatients ≥65 years who attended the Central Emergency COVID-19 Hospital of Castilla y Leon was conducted. In all patients, the protocol of R-MAPP (Malnutrition Universal Screening Tool [MUST] and Simple Questionnaire to Rapidly Diagnose Sarcopenia [SARC-F]) was realized. <b><i>Results:</i></b> The mean age was 86.1 ± 8.7 years, with a sex distribution of 167 males (49.5%) and 170 females (51.5%). According to the MUST test, patients with 0 points have a low nutritional risk (<i>n</i> = 50, 14.8%), 1 point a medium nutritional risk (<i>n</i> = 19, 5.6%), and 2 or more points a high nutritional risk (<i>n</i> = 268, 79.6%). The SARC-F questionnaire generates patients with 4 or more points as predictive of sarcopenia (<i>n</i> = 304, 80.2%) and <4 points without prediction of sarcopenia (<i>n</i> = 33, 9.8%). Global mortality was 24.03% (<i>n</i> = 81). The mortality rate was related to the pathological SARC-F score ≥4 (27.1% vs. 3.1%; <i>p</i> = 0.01) and MUST score ≥2 (26.7% vs. 16.4%; <i>p</i> = 0.04). In the logistic regression analysis, only the SARC-F score ≥4 remained as an independent variable related to mortality; odds ratio was 8.34 (95% CI: 1.1–63.8; <i>p</i> = 0.04), adjusted for age, sex, albumin levels, and MUST test. <b><i>Conclusions:</i></b> During COVID-19 infection, hospitalized patients at risk of sarcopenia have a high risk of mortality and have a poor nutritional status.
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Do Nascimento, Enily Vieira, and Fabiana Lucena Oliveira. "Sistema logístico de recepção e movimentação de cargas aéreas: o caso do pólo indústrial de Manaus (PIM) / Logistics system for reception and handling os air charges: the case of the industrial pole of Manaus (PIM)." Brazilian Journal of Business 4, no. 2 (June 6, 2022): 952–68. http://dx.doi.org/10.34140/bjbv4n2-024.
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A infraestrutura aeroportuária e os serviços de desembaraço aduaneiro de cargas importadas podem ser considerados uma vantagem competitiva das empresas no Pólo Industrial de Manaus (PIM). A redução do tempo de liberação de cargas seria apennas uma das vantagens. O estudo tem como objetivo propor um modelo de gerenciamento ágil e flexível na recepção de cargas aéreas de insumos importados de modo que este atenda satisfatoriamente a Cadeia de Suprimentos Ágil, que tem a capacidade de responder as mudanças, diversidades, demandas imprevisíveis dos clientes, e que reduz os riscos de interrupções dos fornecimentos para as empresas do PIM. Este trabalho, que culmina com um estudo de caso, não somente aborda os fabricantes de produtos high-tech e inovadores, que são de alto valor agregado, mas todos os atores (INFRAERO, RFB, ANVISA, MAPA, DESPACHANTE, Empresas Importadoras) envolvidos na importação da carga, desde sua chegada no TECA até a entrega da carga para o importador. A pesquisa dá visibilidade à importância da infraestrutura e rapidez nos serviços de liberação de cargas importadas, através de um modelo de gerenciamento capaz de incluir o PIM nas exigências da competitividade externa entre as cadeias de suprimento, fazendo uso de estratégias adequadas como o modelo de incerteza da cadeia de suprimentos (MICS). Como resultado obtido é apresentado um modelo identificado como alternativa ao Regime Aduaneiro Especial de Entreposto Industrial sobre Controle Informatizado (RICOF), considerado instrumento de atração e facilitador de desenvolvimento das empresas globais de produtos considerados como integrantes da cadeia de incerteza, de modo que seja observado o ganho logístico e não apenas o tributário, sabendo que no Brasil não se inclui os regimes especiais e atípicos, como as empresas do Pólo Industrial de Manaus (PIM).
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Al-Samkari, Hanny, and David J. Kuter. "Antiplatelet Antibody Testing in Immune Thrombocytopenia and Evans Syndrome: Longitudinal Serologic Evolution and Relation to Clinical Features." Blood 132, Supplement 1 (November 29, 2018): 1137. http://dx.doi.org/10.1182/blood-2018-99-118403.
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Abstract Introduction : Antiplatelet antibody (APA) testing is considered an adjunct laboratory test in the diagnosis of immune thrombocytopenia (ITP). While it is not routinely obtained owing to inconsistent sensitivity and specificity in prior studies (Neunert et al, 2011), the definition of ITP used in these studies was not standardized. Additionally, potential clinical utility of this testing beyond diagnosis has been suggested, such as correlations between certain serologic patterns and response to IVIG (Peng et al, 2014). In consideration of these prior findings, we undertook a retrospective analysis of APA testing [glycoprotein-specific testing done by the commercial PakAuto assay (Immucor, Brookfield, WI), a monoclonal antibody immobilization of platelet antigens (MAIPA) assay, with all testing performed by the same laboratory] utilizing standardized ITP and Evans syndrome (ES) diagnostic criteria for patient inclusion. We examined serologic evolution over time and relation of antibody positivity to disease severity and response to therapies. Methods : Data collected for analysis included dates and results of APA testing (including disease status and platelet count at time of testing), patient demographics, and disease characteristics. Satisfaction of the 2011 American Society of Hematology (ASH) ITP diagnostic criteria were required for ITP patient inclusion and standard definitions of disease severity and response to treatment from the ASH guidelines were used in analysis. Logistic regression was used to model the probability of disease severity (non-severe, severe, or refractory) and treatment response (to corticosteroids or IVIG) based on serologic findings. Longitudinal serologic evolution in patients with multiple APA assays were analyzed. Results : A total of 214 APA assays from 115 ITP patients and 12 ES patients were collected; results from eluate testing (direct assay) only were used in analysis. Baseline patient characteristics are listed in Table 1. Of 7 possible positive test serologic patterns, only 4 were seen (Figure 1); antibodies against both GPIIb/IIIa and GPIb/IX were required for the presence of antibodies against GPIa/IIa. A multinomial logistic regression model including disease severity, age, sex, duration of disease, and platelet count at time of APA assay found a statistically significant predictive relationship between an increasing number of positive antibodies and disease severity [relative to non-severe ITP, relative risk ratio for severe ITP and refractory ITP was 1.89 (P=0.001) and 2.38 (P=0.004), respectively, per one additional positive antibody, Figure 2]. Multiple logistic regression models including antibody positivity to each platelet glycoprotein (GPIIb/IIIa, GPIb/IX, or GPIa/IIa), age, sex, disease duration and splenectomy status found a significant predictive relation between presence of anti-GPIa/IIa and non-response to corticosteroid treatment (odds ratio, 0.082, P=0.008). No significant relation was found between an antibody and non-response to IVIG. Fifty patients had multiple (2 to 5) APA assays performed over months to years. In evaluation of serologic evolution over time, all 7 patients who entered clinical remission also converted from a positive to a negative serology; 22 patients had stable serologic findings over time; 5 patients had a reduction in number of positive antibodies; and 18 patients demonstrated evidence for epitope spreading, with an increase in the number of positive antibodies (Figure 3). The sensitivity of a positive APA assay for the presence of active ITP was 91%. The sensitivity and specificity of a negative APA assay for remission in a patient with previously confirmed ITP (N=40 assays in patients with clinical remission in the study) were 88% and 91%, respectively. Conclusions : The MAIPA-based direct APA assay is sensitive for the presence of active ITP in patients satisfying 2011 ASH diagnostic criteria. To our knowledge, this is the first study demonstrating that a higher number of positive glycoprotein-specific antibodies may predict for more severe disease as defined by 2011 ASH disease severity criteria. Anti-GPIa/IIa antibodies only occur in the setting of pre-existing positivity for both anti-GPIIb/IIIa and anti-GPIb/IX antibodies, possibly due to a distinctive sequence of epitope spreading. Serologic testing typically turns negative when a patient enters clinical remission. Disclosures Al-Samkari: Agios: Consultancy. Kuter:Novartis: Consultancy; Pfizer: Consultancy; Syntimmune: Consultancy; Argenx: Consultancy; Dova Pharmaceuticals: Consultancy, Membership on an entity's Board of Directors or advisory committees; ONO: Consultancy; Amgen Inc.: Consultancy; Bioverativ: Consultancy, Research Funding; Principia: Research Funding; Rigel: Consultancy, Research Funding; BMS: Research Funding; Protalex: Research Funding.
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Calle Flores, Iván A., Rider V. Paredes Maraza, Cristopher Bazan Yaranga, and Aldo A. Guardia Guizado. "Implementación de un robot móvil para optimizar el flujo documentario en el área de logística usando tecnologías de robótica autónoma basada en la plataforma de software libre ROS." Revista Cientifica TECNIA 27, no. 2 (April 4, 2018): 93. http://dx.doi.org/10.21754/tecnia.v27i2.179.
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El presente proyecto consistió en la implementación de un robot móvil autónomo capaz de facilitar el flujo de documentos entre las diferentes áreas de una empresa, universidad, etc. Este robot es capaz de navegar de manera completamente autónoma en ambientes reales tal como los ambientes del CTIC, FIM, FIEE, etc. Tan solo especificando el punto inicial, el mapa del ambiente de navegación, y el punto deseado, este robot es capaz de generar el camino óptimo para llegar a dicha meta, y luego seguir este camino con la capacidad de evitar obstáculos si estos se presentan. Dadas estas características, este robot se puede usar en aplicaciones logísticas en donde el robot debe llevar paquetes, cargas, etc., a algún punto especificado por el usuario. En el proyecto se tienen dos modelos, el primer robot llamado R2D2‐R1 puede llevar cargas de hasta 3kg, y el segundo robot llamado R2D2‐R2 puede llevar cargas de hasta 25kg. Cabe señalar que los algoritmos implementados en este proyecto representan el estado del arte del campo de la robótica autónoma, y su desempeño se ha comprobado en las diversas pruebas de navegación realizadas en ambientes de la UNI. Este proyecto contribuye a cumplir con la misión de la UNI en los temas de innovación y gestión tecnológica para contribuir al bienestar de la sociedad y desarrollo del país. Palabras clave.- Robot móvil, navegación autónoma, planificación de trayectorias, evitamiento de obstáculos, aplicaciones logísticas. ABSTRACT The present project is about the implementation of an autonomous mobile robot designed for logistic tasks in different areas of a company, university, etc. This robot is able to navigate autonomously in real environments, you just need to specify the initial position, the grip map of the world and the target locations, and the robot will generate automatically the optimal path to reach the target positions, and then will follow this path while avoiding obstacles such as persons, trash bins, etc. These characteristics allow that our robot can be used in logistic tasks where the robot needs to carry loads from one place to another. In this project we developed two robot models, the first one called R2d2‐R1 can carry loads of up to 3kg, and the second one called can carry loads of up to 25Kg. The algorithms implemented in this project represent the state‐of‐the‐car methods and its performance has been proved in the several experiments carried out with these two robots. Keywords.- Mobile robot, autonomous navigation, path planning, obstacle avoidance, logistic applications.
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Ahmed, W., A. Goonetilleke, and T. Gardner. "Implications of faecal indicator bacteria for the microbiological assessment of roof-harvested rainwater quality in southeast Queensland, Australia." Canadian Journal of Microbiology 56, no. 6 (June 2010): 471–79. http://dx.doi.org/10.1139/w10-037.
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The study aimed to evaluate the suitability of Escherichia coli , enterococci, and Clostridium perfringens for assessing the microbiological quality of roof-harvested rainwater and assessing whether the concentrations of these faecal indicators can be used to predict the presence or absence of specific zoonotic bacterial or protozoan pathogens. From a total of 100 samples tested, 58%, 83%, and 46% of samples were found to be positive for, respectively, E. coli, enterococci, and Clostridium perfringens spores, as determined by traditional culture-based methods. Additionally, in the samples tested, 7%, 19%, 1%, 8%, 17%, and 15% were PCR positive for Aeromonas hydrophila lip, Campylobacter coli ceuE, Campylobacter jejuni mapA, Legionella pneumophila mip, Salmonella invA, and Giardia lamblia β-giardin genes, respectively. However, none of the samples was positive for E. coli O157 lipopolysaccharide, verocytotoxin 1, and verocytotoxin 2 and Cryptosporidium parvum oocyst wall protein genes. The presence or absence of these potential pathogens did not correlate with any of the faecal indicator bacterial concentrations as determined by a binary logistic regression model. The roof-harvested rainwater samples tested in this study appeared to be of poor microbiological quality, and no significant correlation was found between the concentration of faecal indicators and pathogenic microorganisms. The use of faecal indicator bacteria raises questions regarding their reliability in assessing the microbiological quality of water and particularly their poor correlation with pathogenic microorganisms. The presence of one or more zoonotic pathogens suggests that the microbiological analysis of water should be performed and that appropriate treatment measures should be undertaken, especially in tanks where the water is used for drinking.
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Fortes, Fernanda S., Fernando S. Kloster, Andressa S. Schafer, Daniele Bier, Andréia Buzatti, Ursula Y. Yoshitani, and Marcelo B. Molento. "Evaluation of resistance in a selected field strain of Haemonchus contortus to ivermectin and moxidectin using the Larval Migration on Agar Test." Pesquisa Veterinária Brasileira 33, no. 2 (February 2013): 183–87. http://dx.doi.org/10.1590/s0100-736x2013000200008.
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Haemonchus contortus is one of the most common and economically significant causes of disease in small ruminants worldwide, and the control programs of parasitic nematodes - including H. contortus - rely mostly on the use of anthelmintic drugs. The consequence of the use of this, as the sole sanitary strategy to avoid parasite infections, was the reduction of the efficacy of all chemotherapeutic products with a heavy selection for resistance. The widespread of anthelmintic resistance and the difficulty of its early diagnosis has been a major concern for the sustainable parasite management on farms. The objective of this research was to determine and compare the ivermectin (IVM) and moxidectin (MOX) effect in a selected field strain of H. contortus with a known resistance status, using the in vitro larval migration on agar test (LMAT). Third stage larvae of the selected isolate were obtained from faecal cultures of experimentally infected sheep and incubated in eleven increasing diluted concentrations of IVM and MOX (6, 12, 24, 48, 96, 192, 384, 768, 1536, 3072 and 6144µg/mL). The dose-response sigmoidal curves were obtained using the R² value of >0.90 and the lethal concentration (LC50) dose for the tested anthelmintic drugs using a four-parameter logistic model. The LC50 value for MOX was significantly lower than IVM (1.253µg/mL and 91.06µg/mL), identifying the H. contortus isolate as considerably less susceptible to IVM compared to MOX. Furthermore, the LMAT showed a high consistency (p<0.0001) and provided to be a useful diagnostic tool for monitoring the resistance status of IVM and MOX in H. contortus field isolate, as well as it may be used for official routine drug monitoring programs under the Ministry of Agriculture (MAPA) guidance.
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Mentado Pérez, Lisandra, and Beatriz Mentado Pérez. "Propuesta de procedimiento de control para mejorar el proceso de expedición y aduana en Sherritt-Cubapetróleo." ECA Sinergia 10, no. 1 (January 31, 2019): 19. http://dx.doi.org/10.33936/eca_sinergia.v10i1.1120.
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El proceso de expedición y aduana incluye las operaciones de importación y exportación de mercancía hacia el país, es la vía donde se realiza la tramitación aduanera por parte del Agente de Aduana teniendo bajo su responsabilidad tres aspectos de mucha importancia: La valoración aduanera, mediante la cual se determina la base imponible que determina el pago de los gravámenes; la clasificación arancelaria, por medio de la cual se fijan las preferencias arancelarias que puedan tener las mercancías negociadas en los Tratados de Libre Comercio, y la descripción de las mercancías e inscripción de los productos en las bases de datos de Aduana. Este proceso incluye además los requisitos necesarios para el transporte de los productos de unos países a otros. Para realizar adecuadamente las operaciones de importación y exportación de las mercancías, tanto por la vía aérea como marítima, de acuerdo con la legislación vigente al respecto, es que se desarrolló el presente trabajo, con el objetivo principal de proponer un procedimiento de control, para mejorar el proceso de expedición y aduana en el área logística de SHERRITT-Cubapetróleo. Se utilizaron métodos teóricos y empíricos para fundamentar los resultados. Se partió de la creación del mapa de procesos, describiéndose los mismos para diagnosticar las principales deficiencias que afectan la actividad logística de la entidad y se desarrolló una propuesta de procedimiento para la mejora de los procesos que se llevan a cabo en esta área, en base al seguimiento y medición a través de la definición de indicadores que contribuyen al control con enfoque de sistema.
Palabras clave: procesos administrativos, política pública
ABSTRACT
The process of issuing and customs includes import and export operations of merchandise to the country, it is the way where the customs processing is carried out by the Customs Agent having under his responsibility three aspects of great importance: Customs valuation, through the which determines the tax base that determines the payment of the liens; the tariff classification, by means of which the tariff preferences that the goods negotiated in the Free Trade Agreements may have, and the description of the goods and registration of the products in the Customs databases. This process also includes the necessary requirements for the transportation of products from one country to another. To adequately perform the operations of import and export of goods, both the air and sea, in accordance with the legislation in force in this respect, it is that this work was developed with the aim of proposing a monitoring process, to improve the process of forwarding and customs in the logistics area of SHERRITT-Cubapetroleo. Theoretical and empirical methods were used to substantiate the results. It departed from the creation of the process map, describing them to diagnose the main deficiencies affecting the logistics activities of the entity and developed a proposal for a procedure for the improvement of the processes that are conducted in this area, based on monitoring and measuring through the definition of indicators that contribute to the control with focus on system.
Key words: administrative processes, public policy
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Kaplan-Gouet, Cecile, Corinne Martageix, Vincent Jallu, and Gerald Bertrand. "Is the Maternal Anti HPA-1a Alloantibody Concentration a Predictive Parameter for Fetal Alloimmune Thrombocytopenia?." Blood 106, no. 11 (November 16, 2005): 1233. http://dx.doi.org/10.1182/blood.v106.11.1233.1233.
Full textAbstract:
Abstract Fetal/neonatal alloimmune thrombocytopenia (FNAIT) results from fetomaternal incompatibility for human platelet antigens (HPAs), and the major risk is intracranial hemorrhages (ICH) (up to 20 to 30% of reported cases). In Caucasians HPA-1a is the most frequently involved antigen. The severity of thrombocytopenia usually increases in subsequent pregnancies and antenatal therapy has been developed. Therapy options take into account the risk of ICH in subsequent pregnancies. But until now the only mean to assess the fetal status is performing a fetal blood sampling which carries a risk of fetal loss or premature delivery. The aim of current research is, therefore, to develop non invasive methods for the prediction of disease severity in affected fetuses. We performed a retrospective and prospective study concerning 44 cases of FNAIT, and compared maternal anti HPA-1a alloantibody concentrations with the fetal (FPC) or newborn platelet counts. We recently developed a standardized quantitative MAIPA procedure based on a mathematical approach (four-parameter logistic regression; Bertrand et al., Transfusion, 2005). Taking into account the hemodilution phenomenon during pregnancy maternal anti HPA-1a alloantibody concentrations [expressed in arbitrary units (AU)/mL] were corrected with a factor depending on the gestational term. The results we obtained are as follow: (1) Before antenatal therapy, 31 maternal sera were quantified, when the FPC was concurrently available. Maternal anti HPA-1a alloantibody concentrations >250AU/mL were associated with FPC ≤ 50.109platelets/L in 15/16 cases. Under this threshold 5/15 fetuses were severely affected, showing that the maternal anti HPA-1a alloantibody concentration is predictive of the fetal status only when >250AU/mL. The correlation was statistically validated with Fisher’s exact test only up to 28 weeks of gestation (P=0.015). (2) the maternal anti HPA-1a alloantibody concentration was evaluated for 101 sera during 19 subsequent pregnancies with or without antenatal therapy. We observed a decrease of the maternal anti HPA-1a alloantibody concentration during the pregnancy of 14/19 women including one mother who did not receive any therapy. This decrease was observed despite the correcting factor for the hemodilution. Just before delivery, all women had anti HPA-1a alloantibody concentrations <250AU/mL. In 4 cases there was a therapy failure and severely thrombocytopenic babies required post-natal therapy with IvIgG and/or platelets transfusions. In conclusion, from our results, the maternal anti HPA-1a alloantibody concentration before 28 weeks of gestation could help to predict the severity of the fetal status, if tested in standardized conditions. During pregnancy a trend of decreasing alloantibody concentration does not allow any conclusion about the effectiveness of therapy. If the results of this study are confirmed by a larger cohort, it could provide obstetricians with clinically useful information, concerning appropriateness and timing of invasive monitoring procedure.
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Cuevas Valenzuela, Hernán, Robinson Torres-Salinas, Günter Grosser, Jorge Félez-Bernal, and Jorge Budrovich. "Port-city symbiosis and uneven development: a critical essay on forestry exports and maritime trade from Coronel, Chile." Maritime Economics & Logistics, October 5, 2022. http://dx.doi.org/10.1057/s41278-022-00246-6.
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AbstractThis article explores the concept of port-city territory symbiosis in combination with social and environmental impacts of logistics, port handling, and the global value chains (GVC) of forestry products. Based on fieldwork and a mixed method approach, our analyses of the port-city of Coronel, its forestry hinterland, the port company PuertoCoronel, and the pulp mill MAPA, illustrate a more general pattern of uneven economic, social and spatial development. While forestry and port companies improve and modernize their processes and facilities, the city of Coronel and its territories seem to be left behind. As this case study shows, symbiosis makes an exciting contribution to the study of port-city-territories, if one expands the latter to include its connections to other territories upstream of the GVC, and conceives them as an integral part of the global economy. Additionally, our analysis challenges the concept of symbiosis by providing a critical twist to include phenomena such as environmental injustices and asymmetric relations between companies and local communities and their territories.
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Zhou, Yang, Rui Yang, Yuan Wang, Meng Zhou, Xueyan Zhou, JiQing Xing, Xinxin Wang, and Chunhui Zhang. "Histogram analysis based on multi-parameter MR imaging as a biomarker to predict lymph node metastasis in T3 stage rectal cancer." BMC Medical Imaging 21, no. 1 (November 22, 2021). http://dx.doi.org/10.1186/s12880-021-00706-0.
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Abstract Background Preoperative identification of rectal cancer lymph node status is crucial for patient prognosis and treatment decisions. Rectal magnetic resonance imaging (MRI) plays an essential role in the preoperative staging of rectal cancer, but its ability to predict lymph node metastasis (LNM) is insufficient. This study explored the value of histogram features of primary lesions on multi-parametric MRI for predicting LNM of stage T3 rectal carcinoma. Methods We retrospectively analyzed 175 patients with stage T3 rectal cancer who underwent preoperative MRI, including diffusion-weighted imaging (DWI) before surgery. 62 patients were included in the LNM group, and 113 patients were included in the non-LNM group. Texture features were calculated from histograms derived from T2 weighted imaging (T2WI), DWI, ADC, and T2 maps. Stepwise logistic regression analysis was used to screen independent predictors of LNM from clinical features, imaging features, and histogram features. Predictive performance was evaluated by receiver operating characteristic (ROC) curve analysis. Finally, a nomogram was established for predicting the risk of LNM. Results The clinical, imaging and histogram features were analyzed by stepwise logistic regression. Preoperative carbohydrate antigen 199 level (p = 0.009), MRN stage (p < 0.001), T2WIKurtosis (p = 0.010), DWIMode (p = 0.038), DWICV (p = 0.038), and T2-mapP5 (p = 0.007) were independent predictors of LNM. These factors were combined to form the best predictive model. The model reached an area under the ROC curve (AUC) of 0.860, with a sensitivity of 72.8% and a specificity of 85.5%. Conclusion The histogram features on multi-parametric MRI of the primary tumor in rectal cancer were related to LN status, which is helpful for improving the ability to predict LNM of stage T3 rectal cancer.
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Baxter, Jo-Anna, Yaqub Wasan, Sajid Soofi, Imran Ahmed, and Zulfiqar Bhutta. "Association of Nutritional Status Measures with Self-efficacy and Experiencing Depressed Mood Among Pakistani Young Women (P10-090-19)." Current Developments in Nutrition 3, Supplement_1 (June 1, 2019). http://dx.doi.org/10.1093/cdn/nzz034.p10-090-19.
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Abstract Objectives We aimed to assess self-efficacy and the experience of depression-related emotions among non-pregnant adolescent and young women (15–23 years) living in rural Pakistan, and determine their association with measures of nutritional status. Methods Outcomes were assessed from the Matiari emPowerment and Preconception Supplementation (MaPPS) Trial baseline data (n = 25,279). Self-efficacy and depression-related emotions were determined and categorized using the general self-efficacy scale (low, moderate, and high) and DASS-21 tool (normal, mild, moderate, severe, and extremely severe), respectively. Nutritional status was evaluated using hemoglobin concentration (HemoCue Hb 301 System) and body mass index (BMI). Associations were assessed using ordinal logistic regression, and multivariate models were adjusted for education, parity, wealth index, and clustering. Results The majority of participants were categorized as having moderate self-efficacy (50.6%) and experienced normal range depression-related emotions (76.3%). The mean hemoglobin concentration and BMI were 11.5 ± 1.9 g/dL and 20.2 ± 3.8 kg/m2, respectively. Each unit of increase in hemoglobin was associated with having higher self-efficacy (β = 0.018; 95% confidence interval (CI): 0.005 to 0.031) and lower severe depression-like emotions (β = -0.018; 95% CI: -0.033 to -0.002). Similarly, BMI was associated with higher self-efficacy (β = 0.010; 95% CI: 0.004 to 0.017) and lower severe depression-like emotions (β = -0.014; 95% CI: -0.022 to -0.007). For all models, however, wealth index had a stronger effect on the outcomes of interest. Conclusions Poor nutritional status is suggested to be associated with behavioral organization and one's emotional state. In this setting with a high prevalence of micronutrient deficiencies, we observed associations between lower hemoglobin and BMI with low self-efficacy and experiencing depressed mood, although the effect sizes were small. Findings may reflect potential confounding in the link between empowerment and mood, and poverty. Funding Sources Bill and Melinda Gates Foundation, World Food Programme.