Relevant bibliographies by topics / Mao

Academic literature on the topic 'Mao'

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Published: 4 June 2021
Last updated: 28 July 2024

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Journal articles on the topic "Mao"

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Rivenc, François. "Mai, Mao, Milner." Critique 749, no. 10 (2009): 916. http://dx.doi.org/10.3917/criti.749.0916.

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Yan, Bing, Hongxia Zhu, and Lei Zhou. "Novel Molecular Precursor of Lanthanide Complexes with LongChain Mono Cis-Butene Dicarboxylate to the Controlled Synthesis of Y2O3:Eu3+ Phosphors." Journal of Nanoscience and Nanotechnology 8, no. 3 (March 1, 2008): 1191–98. http://dx.doi.org/10.1166/jnn.2008.18170.

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Maleic anhydride was modified with long chain alcohols (1-hexadecanol, 1-octadecanol, 1-eicosanol and docosyl) to their corresponding amphiphilic mono-L cis-butene dicarboxylates (L = hexadecyl, octadecyl, eicosyl and docosyl). Subsequently, corresponding amphiphilic lanthanide (Y3+, Eu3+) complexes with these four mono-L cis-butene dicarboxylate ligands [Ln(L′)3, Ln = Eu, Y; L′ = MAH, MAO, MAE, MAD] were synthesized. Then, under heating at various temperatures (700, 800, 900, 1000, and 1,100 °C), twenty kinds of nanosized Y2O3:Eu3+ phosphors were prepared using these four as-derived amphiphilic lanthanide (Y3+, Eu3+) complexes as precursors. All four complexes can form nanosized micelle-like aggregates by special self-assembly. Results show that, under heating at 1,000 °C, the four Y2O3:Eu3+ phosphors present more regular dispersion particle-like morphology, and the particle size is in the range of 30–80 nm. They exhibit an especially strong emission at 609 nm, and the luminescence intensity of the sample derived from MAD at 1,000 °C is best.
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Meiyasa, F., N. Taringan, K. U. Henggu, Y. R. Tega, S. Ndahawali, K. E. Zulfamy, M. N. B. Saputro, and I. Priyastiti. "Biological activities of macroalgae in the Moudulung waters: bioactive compounds and antioxidant activity." Food Research 8, no. 1 (January 13, 2024): 82–91. http://dx.doi.org/10.26656/fr.2017.8(1).050.

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This study aimed to determine the bioactive compounds and antioxidant activity of macroalgae in Moudolung Waters. The bioactive compounds in seven samples of macroalgae were extracted with methanol. Analysis of macroalgae bioactive compounds was carried out qualitatively by determining the presence of bioactive compounds including alkaloids, flavonoids, saponins, tannins, phenol hydroquinone, and steroids/ terpenoids. antioxidant activity was carried out using the DPPH (2,2-diphenyl-1-picrylhydrazyl-hydrate) method. Data were analyzed descriptively using Microsoft Excel and all data are expressed as mean. The results showed that these seven macroalgae species have bioactive compounds such as alkaloids, flavonoids, saponins, tannins, phenol hydroquinone, and steroids/terpenoids which function as antioxidants. The highest antioxidant activity was the MA6 (Turbinaria ornate) followed by MA1 (Hormopysa triquetra), MA4 (Ulva flexuosa syn. Enteromorpha flexuosa), MA5 (Eucheuma spinosum), MA2 (Sargassum muticum), MA3 (Gracilaria corticate), and MA7 (Ulva reticulata) were 75.25 mg/mL, 90.31 mg/mL, 134.52 mg/mL, 200.22 mg/mL, 216.91 mg/mL, 259.16 mg/mL, and 270.42 mg/mL, respectively. The results suggested that Turbinaria ornate and Hormopysa triquetra could be used as an important substitute for functional ingredients in foods and pharmaceuticals or nutraceuticals.
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Zedong, Mao. "Mao on Mao." Chinese Sociology & Anthropology 28, no. 1 (October 1995): 33. http://dx.doi.org/10.2753/csa0009-4625280133.

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Limandal, Hüsnü Kamil, and Taha Özkara. "FACTORS AFFECTING MAJOR ADVERSE EFFECTS AFTER CORONARY ARTERY BYPASS SURGERY." Kocatepe Tıp Dergisi 25, no. 2 (September 26, 2023): 221–26. http://dx.doi.org/10.18229/kocatepetip.1315953.

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OBJECTIVE: The present study aimed to evaluate the patient population who underwent coronary artery bypass grafting (CABG) operation in terms of mortality and major adverse effects (MAE) incidence and examine the factors affecting MAE incidence. MATERIAL AND METHODS: 169 consecutive patients who underwent CABG surgery between January 2017 and December 2019 were retrospectively analyzed. Mortality, myocardial infarction, reoperation, cardiac tamponade, stroke, renal failure, sternal infection, need for extracorporeal membrane oxygenator and cardio pulmonary resuscitation were defined as MAO. RESULTS: The mean age of the patients was 63.19 ±0.72 years, the mean duration of cardiopulmonary bypass (CPB) was 106.95 ±27 minutes, and the mean duration of aortic cross-clamp was 44.87 ±1.05 minutes. Extracorporeal membrane oxygenator support was provided to 11 (6.5%) patients, 7 (4.1%) patients underwent reoperation, 5 (3%) patients experienced a postoperative stroke, 5 (3%) patients required cardiopulmonary resuscitation, and postoperative myocardial infarction was observed in 1 (0.6%) patient. In total, MAE was determined in 28 (16.6%) patients. Mortality occurred in 9 (5.3%) patients. In the univariate analysis, Euroscore, mean arterial pressure during CPB, and ultrafiltration volume were associated with MAE (p=0.004, p=0.026, and p=0.037, respectively). However, in multivariate analysis, only Euroscore (odds ratio: 1.453, 95% CI 1.166-1.811 p=0.001) and ultrafiltration volume (odds ratio:-0.002, 95% CI 0.996-1 p=0.04) were correlated to MAE. CONCLUSIONS: In our study, we observed that high Euroscore levels increased not only mortality but also the incidence of MAO, and increased ultrafiltration volumes reduced the incidence of MAO. We believe that it should be kept in mind during CABG surgery that appropriate ultrafiltration and CPB strategy can reduce the incidence of MAO.
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Liu, Liyan. "The Man Who Molded Mao." Modern China 32, no. 4 (October 2006): 483–512. http://dx.doi.org/10.1177/0097700406290790.

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YIN, ZHI-LONG, and BEN-YONG MAO. "A review of Caryanda viridis - species group (Orthoptera: Acrididae) with a new species." Zootaxa 5263, no. 4 (April 11, 2023): 505–19. http://dx.doi.org/10.11646/zootaxa.5263.4.2.

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A new species of Caryanda viridis- species group, i.e. Caryanda biserrata Mao et Yin sp. nov. is described and illustrated. C. xinpingensis Mao, 2017 is included into C. viridis- species group, and C. viridoides Mao, Ren & Ou, 2011 is removed from it. C. viridis- species group presently contains six species: C. viridis (Zheng & Mao, 1996), C. dehongensis Mao, Xu & Yang, 2003, C. albomaculata Mao, Ren & Ou, 2007, C. eshana Mao, 2015, C. xinpingensis Mao, 2017 and C. biserrata Mao et Yin sp. nov.. The key to the six species of C. viridis- species group is updatad.
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Hubálek, Frantisek, Claudia Binda, Ashraf Khalil, Min Li, Andrea Mattevi, Neal Castagnoli, and Dale E. Edmondson. "Demonstration of Isoleucine 199 as a Structural Determinant for the Selective Inhibition of Human Monoamine Oxidase B by Specific Reversible Inhibitors." Journal of Biological Chemistry 280, no. 16 (February 14, 2005): 15761–66. http://dx.doi.org/10.1074/jbc.m500949200.

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Several reversible inhibitors selective for human monoamine oxidase B (MAO B) that do not inhibit MAO A have been described in the literature. The following compounds: 8-(3-chlorostyryl)caffeine, 1,4-diphenyl-2-butene, andtrans,trans-farnesol are shown to inhibit competitively human, horse, rat, and mouse MAO B withKivalues in the low micromolar range but are without effect on either bovine or sheep MAO B or human MAO A. In contrast, the reversible competitive inhibitor isatin binds to all known MAO B and MAO A with similar affinities. Sequence alignments and the crystal structures of human MAO B in complex with 1,4-diphenyl-2-butene or withtrans,trans-farnesol provide molecular insights into these specificities. These inhibitors span the substrate and entrance cavities with the side chain of Ile-199 rotated out of its normal conformation suggesting that Ile-199 is gating the substrate cavity. Ile-199 is conserved in all known MAO B sequences except bovine MAO B, which has Phe in this position (the sequence of sheep MAO B is unknown). Phe is conserved in the analogous position in MAO A sequences. The human MAO B I199F mutant protein of MAO B binds to isatin (Ki= 3 μm) but not to the three inhibitors listed above. The crystal structure of this mutant demonstrates that the side chain of Phe-199 interferes with the binding of those compounds. This suggests that the Ile-199 “gate” is a determinant for the specificity of these MAO B inhibitors and provides a molecular basis for the development of MAO B-specific reversible inhibitors without interference with MAO A function in neurotransmitter metabolism.
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Cho, Hyun-U., Sunpil Kim, Jeongeun Sim, Seulkee Yang, Heeyoung An, Min-Ho Nam, Dong-Pyo Jang, and C. Justin Lee. "Redefining differential roles of MAO-A in dopamine degradation and MAO-B in tonic GABA synthesis." Experimental & Molecular Medicine 53, no. 7 (July 2021): 1148–58. http://dx.doi.org/10.1038/s12276-021-00646-3.

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AbstractMonoamine oxidase (MAO) is believed to mediate the degradation of monoamine neurotransmitters, including dopamine, in the brain. Between the two types of MAO, MAO-B has been believed to be involved in dopamine degradation, which supports the idea that the therapeutic efficacy of MAO-B inhibitors in Parkinson’s disease can be attributed to an increase in extracellular dopamine concentration. However, this belief has been controversial. Here, by utilizing in vivo phasic and basal electrochemical monitoring of extracellular dopamine with fast-scan cyclic voltammetry and multiple-cyclic square wave voltammetry and ex vivo fluorescence imaging of dopamine with GRABDA2m, we demonstrate that MAO-A, but not MAO-B, mainly contributes to striatal dopamine degradation. In contrast, our whole-cell patch-clamp results demonstrated that MAO-B, but not MAO-A, was responsible for astrocytic GABA-mediated tonic inhibitory currents in the rat striatum. We conclude that, in contrast to the traditional belief, MAO-A and MAO-B have profoundly different roles: MAO-A regulates dopamine levels, whereas MAO-B controls tonic GABA levels.
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Prinsloo, Denise, Sandra van Dyk, Anél Petzer, and Jacobus P. Petzer. "Monoamine Oxidase Inhibition by Kavalactones from Kava (Piper Methysticum)." Planta Medica 85, no. 14/15 (September 20, 2019): 1136–42. http://dx.doi.org/10.1055/a-1008-9491.

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AbstractMonoamine oxidases (MAOs) are key metabolic enzymes for neurotransmitter and dietary amines and are targets for the treatment of neuropsychiatric and neurodegenerative disorders. This study examined the MAO inhibition potential of kavain and other kavalactones from the roots of kava (Piper methysticum), a plant that has been used for its anxiolytic properties. (±)-Kavain was found to be a good potency in vitro inhibitor of human MAO-B with an IC50 of 5.34 µM. (±)-Kavain is a weaker MAO-A inhibitor with an IC50 of 19.0 µM. Under the same experimental conditions, the reference MAO inhibitor, curcumin, displays IC50 values of 5.01 µM and 2.55 µM for the inhibition of MAO-A and MAO-B, respectively. It was further established that (±)-kavain interacts reversibly and competitively with MAO-A and MAO-B with enzyme-inhibitor dissociation constants (Ki) of 7.72 and 5.10 µM, respectively. Curcumin in turn, displays a Ki value of 3.08 µM for the inhibition of MAO-A. Based on these findings, other kavalactones (dihydrokavain, methysticin, dihydromethysticin, yangonin, and desmethoxyyangonin) were also evaluated as MAO inhibitors in this study. Yangonin proved to be the most potent MAO inhibitor with IC50 values of 1.29 and 0.085 µM for MAO-A and MAO-B, respectively. It may be concluded that some of the central effects (e.g., anxiolytic) of kava may be mediated by MAO inhibition.
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Dissertations / Theses on the topic "Mao"

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Zhu, Katherine. "Modernity and modernization in Mao Dun's Midnight." Diss., Connect to the thesis, 2007. http://hdl.handle.net/10066/1591.

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梁敏兒 and Man-yee Leung. "Naturalism and Mao Dun's literary theory." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1989. http://hub.hku.hk/bib/B31208733.

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Stenström, Anders. "Intra- and extraneuronal monoamine oxidase (MAO)." Umeå : [University of Umeå], 1986. http://catalog.hathitrust.org/api/volumes/oclc/15239401.html.

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Lai, Yim-ngor Janet. "The narrative art in Mao Dun's short stories Mao Dun duan pian xiao shuo xu shi yan jiu /." Hong Kong : University of Hong Kong, 2000. http://sunzi.lib.hku.hk/hkuto/record.jsp?

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Pang, Hanzhou. "Visual Mao Zedong ideological ideals and rhetorical ordeals /." Pullman, Wash. : Washington State University, 2010. http://www.dissertations.wsu.edu/Dissertations/Spring2010/h_pang_040910.pdf.

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Fresqui, Maíra de Almeida Carvalho. "Modelagem molecular de derivados anfetamínicos e sua atividade antidepressiva." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/75/75131/tde-23042010-102133/.

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As anfetaminas, grupo de moléculas derivadas da anfetamina, são fármacos estimulantes do sistema nervoso central, e possuem, entre outras, atividade antidepressiva sendo sua ação baseada na inativação da enzima monoamina oxidase (MAO) a qual catalisa a desaminação oxidativa de neurotransmissores, como por exemplo, a serotonina e a noradrenalina. Esta enzima pode ser encontrada em duas diferentes isoformas, a MAO A e MAO B. Este trabalho teve como objetivo o estudo de uma série de derivados anfetamínicos os quais apresentam diferente seletividade e diferentes valores de IC50, variando desde moléculas muito potentes, pouco potentes, até inativas, através da aplicação de técnicas de química-quântica no cálculo de descritores moleculares, bem como a aplicação da mecânica clássica na descrição das interações ligante-receptor a partir de estudos de docking e simulações de dinâmica molecular. Inicialmente, foram aplicados os métodos de química-quântica AM1, HF, DFT (com os funcionais B3LYP e BP86) e MP2 para a determinação do nível de teoria mais apropriado para a otimização da geometria desta série de compostos a partir da comparação entre os resultados teóricos e de raios-X obtidos para a molécula MDMA. O método HF/6-31G(d,p) mostrou os melhores resultados. Desta forma, este método foi utilizado na obtenção das geometrias de mínimo das demais moléculas em estudo. Posteriormente, estes métodos foram utilizados no cálculo das propriedades estruturais, eletrônicas e físico-químicas, distribuição de cargas derivadas do potencial eletrostático, momento dipolar, energia total, energia dos orbitais de fronteira, GAP de energia entre o orbital ocupado de mais alta energia (HOMO) e o orbital desocupado de mais baixa energia (LUMO), dureza, potencial químico, eletronegatividade, eletronegatividade absoluta e eletrofilicidade. Assim, foram verificadas possíveis relações entre os descritores calculados e a atividade biológica determinada por Scorza et al, Hurtado-Guzmán et al and Sterling et al.esta para esta série de compostos. A análise destes resultados foi feita através da aplicação da técnica quimiométrica de análise de componentes principais para, desta forma, verificar-se o agrupamento dos compostos segundo a presença ou ausência de atividade biológica na série estudada. Entretanto, não foi possível se identificar um padrão de agrupamento para as moléculas ativas e inativas, sugerindo assim, que estes descritores não são os mais adequados para a descrição da atividade antidepressiva destes compostos. Em uma segunda etapa, foram feitos estudos de docking para seis diferentes estruturas da MAO B (1OJA, 1OJ9, 2BK3, 2V5Z, 2V60 e 2V61) e cinco da MAO A (2BXR, 2BXS, 2Z5X e 2Z5Y) todas disponíveis no banco de dados de proteína, PDB, no qual se avaliou o modo de interação do ligante no sitio ativo da proteína. Os resultados de docking para a MAO B mostraram que o tamanho do inibidor é importante para uma correta interação no sítio ativo da enzima, tendo-se em vista que o tamanho da cavidade catalítica é dependente da conformação do aminoácido isoleucina 199 e, que a conformação deste aminoácido está relacionada com o tamanho do ligante. Desta forma, a escolha correta da estrutura da proteína torna-se importante para uma correta descrição do sistema. Os resultados sugerem ainda que o átomo do ligante, no qual ocorre a reação com o receptor, deve estar a uma distância média de 3,5 Å do sitio reativo. Os resultados de MD mostraram que este aminoácido é flexível na ausência de um inibidor, onde sua conformação varia entre as chamadas formas aberta e fechada ao longo do tempo, porém, quando o estudo é feito na presença de um ligante, sua conformação perrnanece, de modo geral, constante.
The amphetamine family of drugs is central nervous system stimulant drugs. Amphetamine inhibits the monoamine oxidase enzyme (MAO, isoforms A and B) which catalyzes the oxidative deamination of the neurotransmitter, e. g., serotonin and noradrenalin. In the present study, the aim was to understand the main features of a series of amphetamines derivatives, which have different substrate selectivity and a good range of activity varying from very potent to low potent compounds, even inactive molecules by the application of quantum chemistry techniques to calculate the molecular descriptors, as well as the application of a classical mechanics to describe the ligand-receptor interactions from docking studies and molecular dynamics (MD) simulation. First of all, was applied the AM1, HF, DFT (B3LYP and BP86 functionals) and MP2 quantum chemical methods to analyze which theoretical level is more appropriated for the molecular geometry optimization of this series of compounds from a comparison between the theoretical results for MDMA molecule and it\'s X-ray data. The HF/6-3lG** calculations produced results in close agreement with X-ray crystallography. Thus, was employed the same method for the molecular optimization of the other compounds in the series under investigation. Furthermore, the same method was applied to calculate quantum-chemical parameters (atomic charges, total energy, highest occupied molecular orbital -HOMO- lowest unoccupied molecular orbital -LUMO- dipole moments, hardness, electronegativity, chemical potential, absolute electronegativity and electrophilicity). It was examined possible correlations between the theoretical parameters as calculated by us with the biological activity results as reported by Scorza et al, Hurtado-Guzman et al and Sterling et al. The chemometric technique of Principal Component Analysis for the quantum chemical parameters of these compounds was employed in order to identify some pattern of grouping between the active and inactive molecules. However, it was not possible to identify a pattern between active and inactive compounds suggesting that these above-mentioned parameters are not the best descriptors to evaluate the antidepressant activity for this group of molecules. Later, a docking study was performed for six different PDB structure of MAO B (1OJA, 1OJ9, 2BK3, 2V5Z, 2V60 e 2V61) and five different structure of MAO A (2BXR, 2BXS, 2Z5X e 2Z5Y). It was possible to analyze the ligand-receptor interaction and, according to the bind site size, the activity molecules showed a 3.5A distance between the reactive atoms of the inhibitor and of the protein. Because the conformation of the isoleucine 199 (Ile 199) amino acid can change, the chosen of the correct PDB structure is important for a write description of that interaction. The MD results for the 1OJA structure showed that the Ile199 is flexible in the absence of an inhibitor, where its conformation varies between so-called closed and open forms over the simulation time. However, when the study was done in the presence of a ligand, its conformation remains by generally constant.
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Li, Jie. "Sovietology in post-Mao China, 1980-1999." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/22947.

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The breakup of the Union of Soviet Socialist Republics (USSR) in 1991 has had a variety of significant repercussions on Chinese politics, foreign policy, and other aspects. This doctoral project examines the evolution of Chinese intellectual perceptions of the Soviet Union in the 1980s and 1990s, before and after the collapse. Relying on a larger body of updated Chinese sources, this thesis will offer re-evaluations of many key issues in post-Mao Chinese Sovietology. The following topics will be explored or re-examined: Chinese views of Soviet policies in the early 1980s prior to Mikhail Gorbachev’s assumption of power; Chinese perceptions of Gorbachev’s political reform from the mid-1980s onward, before the outbreak of the Tiananmen Incident in 1989; Chinese scholars’ evolving views on Gorbachev from the 1980s to 1990s; the Chinese use of Vladimir Lenin and his policies in the early 1980s and early 1990s for bolstering and legitimizing the CCP regime after the Cultural Revolution and the Tiananmen Incident, respectively; and the re-evaluations of Leonid Brezhnev and Joseph Stalin since the mid-1990s. First, the thesis argues that the changing Chinese views on the USSR were not only shaped by the ups-and-downs of Sino-Soviet (and later Sino-Russian) relations, China’s domestic political climate, and the political developments in Moscow. Even more importantly, views changed in response to the earth-shaking event of the rise and fall of world communism in the last two decades of the 20th century. Second, by researching the country of the Soviet Union, Chinese Soviet-watchers did not focus on the USSR alone, but mostly attempted to confirm and legitimize the Chinese state policies of reform and open door in both decades. By examining the Soviet past, Chinese scholars not only demonstrated concern for the survival of the CCP regime, but also attempted to envision the future direction and position of China in the post-communist world. This included analysis of how China could rise to be a powerful nation under the authoritarian one-party rule, without succumbing to Western democracy and the sort of collapse that doomed the USSR. In short, Chinese research on Soviet socialism has primarily served to trace the current problems of Chinese socialism, in order to legitimize their solutions – rather than a truth-seeking process devoted to knowledge of the Soviet Union.
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Ahland, Michael, and Michael Ahland. "A GRAMMAR OF NORTHERN MAO (MÀWÉS AAS’È)." Thesis, University of Oregon, 2012. http://hdl.handle.net/1794/12456.

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Northern Mao is an endangered Afroasiatic-Omotic language of western Ethiopia with fewer than 5,000 speakers. This study is a comprehensive grammar of the language, written from a functional/typological perspective which embraces historical change as an explanation for synchronic structure. The grammar introduces the Northern Mao people, aspects of their culture and history, and the major aspects of the language: contrastive phonology, tone phenomena, nouns, pronouns, demonstratives, numerals, noun phrases, verbs and verbal morphology, single verb constructions, non-final/medial clauses, subordinate clauses and alignment. The tone system has three contrastive levels, where the Mid tones subdivide into two classes which historically derive from two different sources. Nouns each exhibit two tonal melodies: one melody in citation form or other unmodified environments and another melody when syntactically modified. Extensive coverage is given to developments in the pronominal and subject-marking systems as well as the verbal system. In the pronominal and subject marking systems, innovations include the development of a dual opposition, the fusion of an affirmative verbal prefix to subject prefixes, and the development of these subject prefixes into new pronouns. In the verbal system, innovations include the development of new verbal wordforms from subordinate + final verb periphrastic constructions and a set of new subject markers from an old subordinator morpheme. The verbal system is oriented around two oppositional relations: realis vs. irrealis and finite vs. infinitive verb forms. Realis and irrealis verbs have distinct item-arrangement patterns: realis verbs take subject prefixes while irrealis verbs take subject suffixes. Realis is associated with affirmative polarity and non-future tense and may be used with many aspectual distinctions. Irrealis is associated with negative polarity, future tense, and counterfactual constructions; irrealis verbs do not express many aspectual distinctions. Finite versus infinitive verb stems are differentiated by tone. Finite verb stems are used in affirmative declarative and interrogative utterances, non-final/medial constructions and the more finite subordinate clause structures. Infinitive verb stems are used in negative declarative and interrogative utterances, non-final/medial constructions and the less finite subordinate clause structures. The work concludes with a summary of cross-constructional alignment patterns and evaluates the efficacy of a marked-nominative analysis.
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Anna, Gabriela da Silva Sant. "Efeito de 2-aril(heteroaril)-4,5-diidro-1h-imidazóis sobre a atividade da enzima monoamina oxidase in vitro." Universidade Federal de Santa Maria, 2008. http://repositorio.ufsm.br/handle/1/11095.

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Monoamine oxidase (MAO) is a flavin adenine dinucleotide (FAD)-containing enzyme attached to the mitochondrial outer membrane of neurons, glia, and other cells. Its roles include regulation of the levels of biogenic and xenobiotic amines in the brain and peripheral tissues by catalyzing their oxidative deamination. On the basis of their substrate and inhibitor specificities, two isoforms of MAO have been described (A and B). Due to their role in the metabolism of catecholamines neurotransmitters, MAO-A and MAO-B have long been of pharmacological interest. Accordingly, and reversible and irreversible inhibitors of MAO-A and MAO-B have been used in the clinics to treat neurological disorders including depression and Parkinson´s disease. Since the demonstration that I2- imidazoline sites are associated with mitochondrial membranes 15 years ago, several studies have provided evidence that these sites represent regions on MAOs. In line with this view, it has been demonstrated that imidazoline derivatives inhibit MAO activity. This effect has been attributed to a high affinity I2 binding site on MAO-B (I2B) and to a similar lower affinity site on MAO-A (I2A). This study investigated the effect of 4,5-dihydro-1H-imidazole-2-substituted compounds on MAO activity in vitro by spectrophotometric and fluorimetric methods using kynuramine as substrate. Among the compounds that inhibited MAO-A (3c-e, 3j), compound 3d was 73-fold more selective towards MAO-A than MAO-B. Among the compounds that selectively inhibited MAO-B (3g-I, 3k, 3o), imidazoline 3g was shown to be potent with Ki value of 5,3 μM. Some of compounds that selectively bind to I2-sites, such as 3l (benazoline), 3n (2-BFI), and 3p (BU224) showed good inhibitory activity especially against MAO-B. Imidazolines inhibited MAO-A and MAO-B activities in liver with less selectively than in rat brain. The compounds 3d and 3g reversibly inhibited MAO, and kinetics studies showed that compound 3d and 3g inhibited MAO in a mixed manner (decreased Vmax and increased Km values). These results confirm that imidazolines inhibit MAO activity and suggest a relationship between I2 binding site and modulation of central MAO
A monoamina oxidase (MAO) é uma enzima que contém o dinucleotídeo adenina-flavina (FAD) e que está presente na membrana externa da mitocôndria de células neuronais, glia e outras células. Seu papel inclui a regulação dos níveis de aminas biogênicas e xenobióticas no cérebro e em tecidos periféricos pela desaminação oxidativa. Com base na especificidade a substrato e inibidores, são descritas duas isoformas da MAO (A e B). Devido aos seus papéis no metabolismo das catecolaminas neurotransmissoras, a MAO-A e a MAO-B são consideradas farmacologicamente interessantes, e inibidores reversíveis e irreversíveis destas isoformas são usados clinicamente para tratar doenças neurológicas incluindo depressão e doença de Parkinson. Nos últimos 15 anos, desde a demonstração que sítios I2 estão associados com frações da membrana mitocondrial, muitos estudos provem evidências de que estes sítios representam regiões da MAO. Além disso, alguns estudos têm demonstrado que derivados imidazolínicos são capazes de inibir a atividade da MAO. Este efeito tem sido atribuído a sítios I2 de alta afinidade na MAO-B (I2B) e a um sítio similar de baixa afinidade na MAO-A (I2A). Assim, este estudo teve como objetivo investigar o efeito in vitro de compostos 4,5-diidro-1H-imidazol-2-substituídos sobre a atividade da enzima monoamina oxidase através de métodos espectrofotométricos e fluorimétricos usando quinuramina como substrato. Entre os compostos estudados que inibiram preferencialmente a MAO-A (3c-e, 3j) apenas o composto 3d foi seletivo, apresentando um Ki para a MAO-A de aproximadamente 73 vezes menor do que seu Ki para MAO-B. Entre os compostos obtidos que seletivamente inibiram MAO-B (3g-l, 3K, 3o), apenas a imidazolina 3g mostrou ser potente, com valores de Ki de 5,3 μM. Alguns compostos que exercem ligação potente e seletiva à sítios I2, como o 3l (benazolina), 3n (2-BFI) e 3p (BU224) mostraram boa atividade inibitória especialmente contra MAO-B. Em fígado de ratos, as imidazolinas inibiram com menos seletividade a MAO-A e MAO-B quando comparado com cérebro de ratos. Os compostos 3d e 3g inibiram a MAO de maneira reversível e apresentaram inibição de natureza mista (diminuindo o valor de Vmáx e aumentando o valor de Km) sobre a enzima MAO. Estes resultados confirmam que drogas imidazolinas podem inibir a atividade da MAO e sugerem uma relação entre sítios I2 e a modulação da atividade da enzima.
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Tran, Phu-Dennis. "Ethen-Norbornen-Copolymerisation durch Single-site-Katalysatoren-MAO." [S.l. : s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=968875459.

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Books on the topic "Mao"

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wen, Sun bo, and En de. Mao mao. Xi an: Shi jie tu shu chu ban xi an you xian gong si, 2013.

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Li shi xun, (1945- ), ed. Mao mao. 3rd ed. Nan chang: Er shi yi shi ji chu ban she, 2006.

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ill, Yun Chŏng-ju 1971, and Li Yinghua, eds. Mao mao chong chi mao mao chong. Taibei Xian Yonghe Shi: Gou gou tu shu you xian gong si, 2003.

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Rongzhen, Zheng, ed. Mai mao zi. Taibei Shi: Shang yi wen hua shi ye gu fen you xian gong si, 1988.

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ill, Yin Lu, and Chen Yi, eds. Za mao mao. [Xianggang] Quanwan: Jiao yu chu ban she you xian gong si, 2004.

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Lan mo shui bian yi zhong xin, ed. Mao mao jing. Tai bei shi: Lan mo shui chu ban, 1995.

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Lu, Yin, ed. Za mao mao. Nanjing shi: Jiangsu shao nian er tong chu ban she, 2001.

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Khap, Mūnnithi Mao Mai. Mūnnithi Mao Mai Khap. Bangkok]: Mūnnithi Mao Mai Khap, 2007.

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Khap, Mūnnithi Mao Mai. Kanlayānamit Mao Mai Khap. Krung Thēp: Mūnnithi Mao Mai Khap, 2012.

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Dingli, Xiao. Mao mao xiao jie tong hua wu: Mao mao xiao jie. Beijing: Xian dai chu ban she, 2016.

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Book chapters on the topic "Mao"

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Lynch, Michael. "Introduction." In Mao, 1–22. Second edition. | New York : Routledge, 2017. | Series: Routledge historical biographies: Routledge, 2017. http://dx.doi.org/10.4324/9781315200514-1.

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Lynch, Michael. "Young Mao." In Mao, 23–56. Second edition. | New York : Routledge, 2017. | Series: Routledge historical biographies: Routledge, 2017. http://dx.doi.org/10.4324/9781315200514-2.

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Lynch, Michael. "Mao the Communist and Nationalist: 1921–30." In Mao, 57–89. Second edition. | New York : Routledge, 2017. | Series: Routledge historical biographies: Routledge, 2017. http://dx.doi.org/10.4324/9781315200514-3.

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Lynch, Michael. "From Futian to the Long March: 1930–35." In Mao, 90–120. Second edition. | New York : Routledge, 2017. | Series: Routledge historical biographies: Routledge, 2017. http://dx.doi.org/10.4324/9781315200514-4.

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Lynch, Michael. "The Yanan years: 1935–43." In Mao, 121–56. Second edition. | New York : Routledge, 2017. | Series: Routledge historical biographies: Routledge, 2017. http://dx.doi.org/10.4324/9781315200514-5.

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Lynch, Michael. "Years of triumph: 1943–50." In Mao, 157–86. Second edition. | New York : Routledge, 2017. | Series: Routledge historical biographies: Routledge, 2017. http://dx.doi.org/10.4324/9781315200514-6.

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Lynch, Michael. "Emperor of the Blue Ants: 1950–62." In Mao, 187–226. Second edition. | New York : Routledge, 2017. | Series: Routledge historical biographies: Routledge, 2017. http://dx.doi.org/10.4324/9781315200514-7.

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Lynch, Michael. "The cult of Mao and the Cultural Revolution: 1962–76." In Mao, 227–65. Second edition. | New York : Routledge, 2017. | Series: Routledge historical biographies: Routledge, 2017. http://dx.doi.org/10.4324/9781315200514-8.

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Lynch, Michael. "Mao Zedong: an assessment." In Mao, 266–87. Second edition. | New York : Routledge, 2017. | Series: Routledge historical biographies: Routledge, 2017. http://dx.doi.org/10.4324/9781315200514-9.

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Bauer, Wolfgang. "Mao Zedong: Mao zhuxi yulu." In Kindlers Literatur Lexikon (KLL), 1–2. Stuttgart: J.B. Metzler, 2020. http://dx.doi.org/10.1007/978-3-476-05728-0_15081-1.

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Conference papers on the topic "Mao"

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Tanaka, Sun, and Shinya Takamaeda-Yamazaki. "MAO: Memory Architecture Obfuscation." In 2023 IEEE 16th International Symposium on Embedded Multicore/Many-core Systems-on-Chip (MCSoC). IEEE, 2023. http://dx.doi.org/10.1109/mcsoc60832.2023.00042.

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Orzechowski, T. "Simulation approach to MAO Service implementation." In EUROCON 2005 - The International Conference on "Computer as a Tool". IEEE, 2005. http://dx.doi.org/10.1109/eurcon.2005.1630022.

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He, Xiaxu, Pengfei Liu, Kejing He, and Weifeng Zhang. "Knowledge Map Analysis of Mao Zedong Thought Research Based on CSSCI Papers." In 2019 IEEE 4th International Conference on Cloud Computing and Big Data Analysis (ICCCBDA). IEEE, 2019. http://dx.doi.org/10.1109/icccbda.2019.8725762.

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Hundt, Robert, Easwaran Raman, Martin Thuresson, and Neil Vachharajani. "MAO — An extensible micro-architectural optimizer." In 2011 9th Annual IEEE/ACM International Symposium on Code Generation and Optimization (CGO). IEEE, 2011. http://dx.doi.org/10.1109/cgo.2011.5764669.

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Shi, Yiwen. "Mao Zedong's Awareness of Ruling Crisis in 1960s." In 2014 International Conference on Education Technology and Social Science. Paris, France: Atlantis Press, 2014. http://dx.doi.org/10.2991/icetss-14.2014.37.

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Zhao, Zheng, Beibei Feng, Xingtuan Yang, and Yanfei Sun. "Prospect of MAO Technology Application in Nuclear Power Industry." In 2013 21st International Conference on Nuclear Engineering. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/icone21-15435.

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Abstract:
Micro arc oxidation (MAO) technology known as a newly surface treatment technology has got a widely application in the field of aviation, aerospace, automotive, electronics, and medical industry. Strength, toughness, hardness and corrosion of valve metal such as aluminum, magnesium, copper, zinc, zirconium and their alloys can be greatly improved by MAO technology. This paper tries to probe into the feasibility of using MAO technology in nuclear power industry. Aluminum and its alloys are used as structural materials such as the cladding of reactor fuel and all kinds of pipes in the low nuclear reactor. Zirconium alloys are widely used for the fuel cladding, cannula, catheter and other components of the fuel assemblies. Titanium and its alloys offer a unique combination of desirable mechanical properties which makes them to be the candidate materials for structural application in the field of nuclear energy. The surface of all these materials may be destroyed which increasing the risk of the nuclear accident due to the severe serving conditions. As a result, it is necessary to improve the corrosion and wear resistance behavior. With the urgent requirements of safety and durability of nuclear reactor, MAO technology must have a broad prospect in nuclear industry.
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Kozuka, M., T. Minamide, H. Saito, K. Otsuka, M. Takao, and K. Mitsubayashi. "An Optical Halitosis (Bad Breath) Sensor with Mao-A." In 2006 5th IEEE Conference on Sensors. IEEE, 2006. http://dx.doi.org/10.1109/icsens.2007.355543.

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Li, Shuang. "Mao Zedong's Class Analysis Method and Its Contemporary Value." In Proceedings of the 2018 8th International Conference on Management, Education and Information (MEICI 2018). Paris, France: Atlantis Press, 2018. http://dx.doi.org/10.2991/meici-18.2018.266.

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Golubkov, Pavel, Ekaterina Pecherskaya, Oleg Karpanin, Maksim Safronov, Juliya Shepeleva, and Aliya Bibarsova. "Intelligent Automated System of Controlled Synthesis of MAO-Coatings." In 2019 24th Conference of Open Innovations Association (FRUCT). IEEE, 2019. http://dx.doi.org/10.23919/fruct.2019.8711874.

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Vogel, S., K. Schötz, and E. Koch. "Flavonoide aus Rhodiola rosea mit moderaten MAO-inhibierenden Eigenschaften." In Phytotherapie 2017 „Von der Innovation zur Evidenz“. Georg Thieme Verlag KG, 2017. http://dx.doi.org/10.1055/s-0037-1607183.

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Reports on the topic "Mao"

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Reilly, Thomas P. Mao Tse-Tung and Operational Art During the Chinese Civll War. Fort Belvoir, VA: Defense Technical Information Center, May 1998. http://dx.doi.org/10.21236/ada357835.

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Liu, Meiru. Administrative Reform in China: its Impact on Economic Development after Mao. Portland State University Library, January 2000. http://dx.doi.org/10.15760/etd.1346.

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Kelshaw, Christopher J. From Mao toward Modernity: The Increasing Westernization of the People's Liberation Army. Fort Belvoir, VA: Defense Technical Information Center, May 2014. http://dx.doi.org/10.21236/ada612233.

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Barron, Andrew R. Tert-butylalumoxanes: Synthetic Analogs for Methylalumoxane (MAO) and New Catalytic Routes to Polyolefins and Polyketones. Fort Belvoir, VA: Defense Technical Information Center, June 1994. http://dx.doi.org/10.21236/ada280511.

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Roots, C. F., and D. C. Murphy. Geology of Mayo map area [105m]. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 1992. http://dx.doi.org/10.4095/133297.

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Johnson, Scott, Randolph Settgast, Pengcheng Fu, Tarabay Antoun, and F. J. Ryerson. GEOS Code Development Road Map - May, 2013. Office of Scientific and Technical Information (OSTI), May 2013. http://dx.doi.org/10.2172/1248286.

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Novichkova, Tatiana. Political administrative map of Isle of Man. Edited by Nikolay Komedchikov, Alexandr Khropov, and Larisa Loginova. Entsiklopediya, July 2013. http://dx.doi.org/10.15356/dm2016-02-12-10.

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Gordey, S. P. Selwyn Mountains Geology: Ne Mayo map area. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 1990. http://dx.doi.org/10.4095/131201.

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Glenn, J. W. BTA Magnet Field Map Archive and MAD Model. Office of Scientific and Technical Information (OSTI), April 2008. http://dx.doi.org/10.2172/939974.

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Glenn J. W. BTA Magnet Field Map Archive and MAD Model. Office of Scientific and Technical Information (OSTI), April 2008. http://dx.doi.org/10.2172/1061896.

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