Journal articles on the topic 'Manufacturing USA Institutes'
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Cooper, Khershed. "(Invited) NSF Advanced Manufacturing Program and Nanomanufacturing Research." ECS Meeting Abstracts MA2023-01, no. 16 (August 28, 2023): 1456. http://dx.doi.org/10.1149/ma2023-01161456mtgabs.
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NSF’s Advanced Manufacturing (AM) program supports transformative advances in materials engineering, processing and manufacturing and fosters multidisciplinary research that applies innovative manufacturing approaches to accelerate new product development, customize products, increase production efficiency and reduce production cost. AM is a basic research program the outcomes of which could lead to applications of interest to Industry. The AM program engages industry participation through the GOALI mechanism and through collaborations with the Manufacturing USA Institutes. The AM portfolio includes the entire spectrum of manufacturing processes including nanomanufacturing. Nanomanufacturing is the fabrication of nanoscale (1-100 nm) building-blocks, their assembly into higher-order structures, and the integration of these into larger scale systems. Nanomanufacturing research is the study of processes to manipulate and control matter at the nanoscale in 1-, 2-, and 3-dimensions, reproducibly. This presentation describes the AM program with a focus on Nanomanufacturing research and its role in cross-cutting initiatives.
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Baitanayeva, B. A., S. K. Kondybayeva, G. K. Andabayeva, and A. A. Sagynbayeva. "Development of innovative activity of universities: domestic and international experience." Bulletin of "Turan" University, no. 1 (March 30, 2024): 323–36. http://dx.doi.org/10.46914/1562-2959-2024-1-1-323-336.
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The Republic of Kazakhstan has adopted the State Program of Industrial and Innovative Development for 2020-2025, the purpose of which is to achieve the competitiveness of the manufacturing industry in the domestic and foreign markets. The success of the implementation of this program largely depends on the combined efforts of university science, the potential of research institutes, business, with state support in the field of budget financing and in other areas. The purpose of the study is to identify the challenges facing the modern Kazakh higher education system in the context of economic modernization to increase its sustainability and competitiveness. In this regard, special attention is paid to the innovative component of any field of activity. The article, based on the study of world experience, identifies the main problems that hinder innovation activity at universities in Kazakhstan and provides recommendations on how to overcome them. As the pace of discovery and competition accelerates at the global level, universities are creating a culture in which entrepreneurship and innovative thinking are encouraged. Students under the guidance of teachers actively develop startups, striving to change society for the better by participating in social entrepreneurship. Innovative activities of universities are accompanied by the establishment of partnerships with leading companies and research institutes. The article presents the experience of leading universities in the USA, as well as universities in Central and Eastern Europe, Tokyo University (Japan) to increase the innovation activity of Kazakhstani universities. Traditional methods of analysis and synthesis, logical thinking, systematization and generalization of accumulated material were used to uncover the issues under study.
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Maher, Theodore J., and Michael P. Spencer. "Taking the University to Rural Manufacturers in the USA." Industry and Higher Education 11, no. 6 (December 1997): 355–60. http://dx.doi.org/10.1177/095042229701100605.
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This paper examines how the Cooperative Extension System can be positioned as a collaborator in advancing manufacturing modernization in the USA. The authors consider whether the Cooperative Extension System has an interest in assisting manufacturers and, if so, what capacity it can bring that is complementary to the National Institute of Standards and Technology's (NIST) Technology Centers. They also assess whether there are sufficient parallel interests between the NIST Manufacturing Extension Partnership programme (in rural areas) and the Cooperative Extension System to warrant closer coordination and collaboration at the federal, state and local levels.
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Chen, X. L., Z. Yang, A. Nanjundan, N. Chen, and J. J. Janosch. "Achieving manufacturing quality and reliability using thru-process simulation." Journal de Physique IV 120 (December 2004): 793–800. http://dx.doi.org/10.1051/jp4:2004120092.
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Manufacturing of heavy industrial components such as the front linkage, case frame and car body of construction and mining equipments involves multiple processes including thermal cutting, bending/forming and welding. Distortion, welding joint integrity and manufacturing variability pose significant challenges on today's manufacturing. In this paper, the authors presented VFT$^{\tiny TM}$- Virtual Fabrication Technology [1], a thru-process simulation package, developed at the technical center of Caterpillar Inc., Peoria, IL, USA and Battelle Memorial Institute, Columbus Ohio, USA. VFT is a trademark of Battelle Memorial Institute. This work was performed under the support of the US Department of Commerce, National Institute of Standards, Advanced Technology Program. Steel rolling simulation, thermal cutting simulation, bending and welding simulation capabilities in the VFT software have significantly reduced the time and cost of manufacturing process developments as well as to achieve competitive advantages through quality improvement and differentiated products. Besides the Caterpillar applications, VFT software has also found applications in shipbuilding, nuclear piping, and automotive industry.
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Tkachenko, O., I. Kulaga, L. Kozlovska, O. Shvidanenko, and T. Busarieva. "The impact of knowledge components on the world competitiveness." Naukovyi Visnyk Natsionalnoho Hirnychoho Universytetu, no. 1 (2021): 198–203. http://dx.doi.org/10.33271/nvngu/2021-1/198.
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Purpose. To analyze the impact of the knowledge component on the level of global competitiveness of the world. Methodology. The methodological basis of the article is the methods and forms of scientific knowledge adopted in domestic science, such as system approaches, comparative and synthesis methods, methods of abstract logical evaluation, methods of detailing, groupings and generalizations, experts evaluations; dynamics series, logic analysis, paired and multiple correlation techniques. Moreover, the Google Trends search engine was used, since the use of this search tool allowed drawing the following conclusions: searches for both concepts in the world and in Ukraine are substantially different: both concepts in the global space, particularly in countries with a high level of competitiveness, are hardly in demand. Findings. Knowledge as an economic category and practical skill permeates all spheres of human life. Currently, knowledge formation is concentrated within TNCs localized in the developed countries of the world (the USA, Singapore, the EU countries, Japan, and others), which is confirmed by the level of competitiveness of the economy of these countries and high ranking of the knowledge component in it. In the overall rating of competitiveness of the influence of the components of the knowledge economy, Ukraine ranks below average, while science now barely crosses the threshold of performing a sociocultural function and begins to perform a cognitive one. Originality. Globalization processes and technological revolution of recent decades have transformed knowledge and intellectual capital into key drivers of competitiveness in the world. We have formed and studied groups of subjective (regional and state policy, which determines the quality of economic and financial processes, as well as the management of the public sector) and objective (geographic, natural and climatic conditions, the degree of sufficiency in raw materials, infrastructure, and others) factors affecting competitiveness of countries. According to the research results, the use of this approach allows for continuous monitoring of the competitiveness level of social and economic indicators in order to identify and eliminate bottlenecks in various levels of state management. Practical value. The authors approach suggested is recommended to be used by scientific institutes, universities, government bodies and services for monitoring socio-economic indicators included in the groups of objective and subjective factors in order to form a holistic understanding and systematic analysis of the influence of the competitiveness of the knowledge component on different aspects of the countrys social and economic life.
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Sagadatova, N. M., M. S. Absalyamov, and G. K. Zainutdinova. "Wetlab training: a new approach to ophthalmic surgeons training." Reflection, no. 1 (September 20, 2023): 72–75. http://dx.doi.org/10.25276/2686-6986-2023-1-72-75.
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The article presents the results of Wetlab work in Ufa Eye Research Institute for 2014–2023. The described method of teaching includes theoretical training, step-by-step mastering of phacoemulsification in the training class, work at the operation unit as well as the algorithm for diagnosis and management of patients in the postoperative period. The successful work of Wet Laboratory in Ufa Eye Research Institute has made phaco training more accessible for opthtalmologists from Russia and neighbouring countires. Key words: Ufa Eye Research Institute; Wetlab; results of work.
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Neuenfeldt Júnior, Alvaro Luiz, Julio Cezar Mairesse Siluk, and Elpidio Oscar Benitez Nara. "Estudo de um fluxo interno de materiais baseado na filosofia Lean Manufacturing." Production 25, no. 3 (August 18, 2015): 691–700. http://dx.doi.org/10.1590/0103-6513.112312.
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Nos últimos anos, é notória a evolução das empresas brasileiras no que tange a busca por otimizar os seus resultados industriais. Estudos do Lean Institute Brasil (2012) indicam que as indústrias do Brasil são, em média, as que necessitam o maior número de horas extras para o cumprimento das operações de manufatura, fato diretamente vinculado à elevada quantidade de estoques entre processos, desperdícios na movimentação e armazenagem de materiais. Logo, o artigo objetiva desenvolver uma metodologia que viabilize o estudo da maneira na qual funciona a cadeia de suprimentos interna de empresas fabricantes de ônibus do Brasil, em específico para os seus componentes comprados, com base no método denominado Making Materials Flow, para a correção das situações elencadas, havendo, ao final, uma redução em 40% do total de itens em falta para a linha de montagem e colaborando para o aumento de 37% na produção por dia.
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Boland, Billy. "Quality improvement in mental health services." BJPsych Bulletin 44, no. 1 (October 4, 2019): 30–35. http://dx.doi.org/10.1192/bjb.2019.65.
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Quality improvement (QI) approaches are becoming increasingly important in the delivery of mental healthcare internationally. They were originally developed in the manufacturing industry, but the principle of having a systematic approach to improvement has spread to many other industries, not least to healthcare. Quality improvement approaches in healthcare were pioneered in the USA at organisations such as Virginia Mason and the Institute for Healthcare Improvement. In recent years, they have become firmly established in mental health services in the UK's National Health Service (NHS). There are a number of different approaches to quality improvement, but two leading models have taken root: ‘lean thinking’ (also known as ‘lean methodology’ or simply ‘lean’), which arose out of Virginia Mason, and the ‘Model for Improvement’, which came out of the Institute of Healthcare Improvement. This article describes these two quality improvement approaches, critiques their philosophy and explores how they can apply in the provision of mental healthcare, particularly with reference to the use of data, evidence and metrics.
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Heragu, Sunderesh S., Smart Khaewsukkho, and Shahrukh A. Irani. "A review of: “SPIRAL” SPIRAL was developed by Marc Goetschalckx Industrial and Systems Engineering Department, Georgia Institute of Technology, Atlanta, GA, USA." IIE Transactions 32, no. 7 (July 2000): 677. http://dx.doi.org/10.1080/07408170008967425.
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Nastac, Laurentiu. "3D Modeling of the Solidification Structure Evolution of Superalloys in Powder Bed Fusion Additive Manufacturing Processes." Metals 11, no. 12 (December 10, 2021): 1995. http://dx.doi.org/10.3390/met11121995.
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Recently, a few computational methodologies and algorithms have been developed to simulate the microstructure evolution in powder bed fusion (PBF) additive manufacturing (AM) processes. However, none of these have attempted to simulate the grain structure evolution in multitrack, multilayer AM components in a fully 3D transient mode and for the entire AM geometry. In this work, a multiscale model, which consists of coupling a transient, discrete-source 3D AM process model with a 3D stochastic solidification structure model, was applied to quickly, efficiently, and accurately predict the grain structure evolution of IN625 alloys during Laser Powder Bed Fusion (LPBF). The capabilities of this model include studying the effects of process parameters and part geometry on solidification conditions and their impact on the grain structure formation within multicomponent alloy parts processed via AM. Validation was accomplished based on single-layer LPBF IN625 benchmark experiments, previously performed and analyzed at the National Institute of Standards and Technology (NIST), USA. This modeling approach can also be used to quantitatively predict the solidification structure of Ti-6Al-4V alloys in electron beam AM processes.
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Barros, Fernando Rufino de, and Hudson Fernandes Amaral. "AVALIAÇÃO DA EFICIÊNCIA DOS INSTITUTOS FEDERAIS NO NORDESTE BRASILEIRO." Revista Valore 7 (March 19, 2022): 131–51. http://dx.doi.org/10.22408/reva7120221097131-151.
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A educação profissional e tecnológica possui grande importância para a região em que se instala, sendo uma das responsáveis por capacitar a mão de obra necessária para suprir as demandas do mercado de trabalho e da economia. Neste sentido, objetivou-se com este estudo avaliar a eficiência das instituições federais que compõem a RFEPCT no Nordeste do Brasil nos períodos de 2017-2019 por meio da Análise Envoltória de Dados em conjunto com o Índice de Produtividade de Malmquist. Os resultados encontrados mostraram que apenas três instituições se mantiveram na fronteira eficiente para todos os anos avaliados. Quanto ao índice de produtividade, a média total da amostra apresentou pouco avanço, somente 3% na relação produto/insumo. Conclui-se que, mesmo com aumento na produtividade, a maioria das unidades ainda tem capacidade de ampliar seus resultados, sendo necessária uma melhor atuação da gestão para alocação dos seus insumos de forma assertiva.Palavras-chave: DEA. Índice de Malmquist. Eficiência. Educação Profissional.
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Pransky, Joanne. "The Pransky interview: Dr Howie Choset, CTO, Advanced Robotics for Manufacturing Institute; Professor, Carnegie Mellon; snake robotics inventor and entrepreneur." Industrial Robot: An International Journal 44, no. 5 (August 21, 2017): 571–74. http://dx.doi.org/10.1108/ir-06-2017-0113.
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Purpose The following paper is a “Q&A interview” conducted by Joanne Pransky of Industrial Robot Journal as a method to impart the combined technological, business and personal experience of a prominent, robotic industry PhD-turned-entrepreneur regarding the commercialization and challenges of bringing a technological invention to market. The paper aims to discuss these issues. Design/methodology/approach The interviewee is Dr Howie Choset, Chief Technical Officer at the Advanced Robotics for Manufacturing Institute and Professor of Robotics at Carnegie Mellon University (CMU). Motivated by applications in confined spaces, Dr Choset created a comprehensive program in modular, high degree(s) of freedom (DOF) and multirobot systems. This research led Dr Choset to cofound three companies. In this interview, Dr Choset shares some of his personal and business experiences of working in academia and industry. Findings Dr Choset received his Bachelor of Science, Engineering (BSE) degree in computer science and his Bachelor of Science, Economics (BSEcon) degree in business from the University of Pennsylvania in 1990. Dr Choset received his Masters and PhD from Caltech in mechanical engineering and robotics in 1991 and 1996. Since 1996, Dr Choset has been a Professor of Robotics at CMU and Director of the CMU Biorobotics Lab. He is also the Director of CMU’s undergraduate major and minor of Robotics. Along with his students, Choset formed several companies including Medrobotics (2005) for surgical systems; Hebi Robotics (2014) for modular robots; and Bito Robotics (2017) for autonomous guided vehicles. In 2017, Choset co-led the formation of the Advanced Robotics for Manufacturing Institute, which is a $250m national institute advancing both technology development and education for robotics in manufacturing. Choset is a founding editor of the journal Science Robotics and is currently serving on the editorial board of International Journal Robotics Research. Originality/value Motivated by collaborating with his students and colleagues, Dr Choset continues to make fundamental contributions in design, motion planning, path planning and estimation with the goal of bringing the precision of computer science and applied mathematics to the realities and uncertainties of mechanical systems. Choset’s work has been supported by both industry and government. Medrobotics Corp., a medical robotics company based on Choset’s snake robots, has received US Food and Drug Administration (FDA) regulatory clearance for both colorectal and otolaryngology procedures in the USA.
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Beck, Lee. "Carbon capture and storage in the USA: the role of US innovation leadership in climate-technology commercialization." Clean Energy 4, no. 1 (December 24, 2019): 2–11. http://dx.doi.org/10.1093/ce/zkz031.
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Abstract To limit global warming and mitigate climate change, the global economy needs to decarbonize and reduce emissions to net-zero by mid-century. The asymmetries of the global energy system necessitate the deployment of a suite of decarbonization technologies and an all-of-the-above approach to deliver the steep CO2-emissions reductions necessary. Carbon capture and storage (CCS) technologies that capture CO2 from industrial and power-plant point sources as well as the ambient air and store them underground are largely seen as needed to address both the flow of emissions being released and the stock of CO2 already in the atmosphere. Despite the pressing need to commercialize the technologies, their large-scale deployment has been slow. Initial deployment, however, could lead to near-term cost reduction and technology proliferation, and lowering of the overall system cost of decarbonization. As of November 2019, more than half of global large-scale CCS facilities are in the USA, thanks to a history of sustained government support for the technologies. Recently, the USA has seen a raft of new developments on the policy and project side signaling a reinvigorated push to commercialize the technology. Analysing these recent developments using a policy-priorities framework for CCS commercialization developed by the Global CCS Institute, the paper assesses the USA’s position to lead large-scale deployment of CCS technologies to commercialization. It concludes that the USA is in a prime position due to the political economic characteristics of its energy economy, resource wealth and innovation-driven manufacturing sector.
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Alves, Alex da Silva, and José-Antônio Pimenta-Bueno. "Uma análise exploratória do financiamento público à interação universidade-empresa no Brasil." Production 24, no. 4 (September 24, 2013): 898–910. http://dx.doi.org/10.1590/s0103-65132013005000073.
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O artigo explora o tema do financiamento do esforço de inovação das empresas por meio de parcerias com institutos de ciência e tecnologia, os quais, juntos, formam um importante indutor de políticas de fomento à inovação. No caso brasileiro, a combinação dos recursos de fomento federais e estaduais e a infraestrutura montada nas ICTs nas últimas décadas participam na consolidação desse esforço. O artigo traz reflexões sobre a interação universidade-empresa para a inovação a partir de uma survey realizada junto a ICTs e empresas participantes de um programa nacional de fomento entre 2002 e 2007, intitulado Coopera. Este artigo busca elucidar esses e outros aspectos da natureza da relação criada pelo Coopera. Embora se reconheçam os avanços alcançados, a análise sugere que o programa ainda não logrou estabelecer a qualidade e a periodicidade do relacionamento de que depende o esforço continuado de inovação no meio empresarial brasileiro.
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Varnavskii, V. "The Chinese Phenomenon of Economic Growth." World Economy and International Relations 66, no. 1 (2022): 5–15. http://dx.doi.org/10.20542/0131-2227-2022-66-1-5-15.
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Modern China should be considered as an unique experiment and great world project of human civilization, effectively a co-product of the Communist Party of China (CPC) and the West. The centuries-old concept of a free-market economy fell on fertile ground of the hardworking Chinese people and in a short historical period since the beginning of the reform has finally bore fruit. Globalization and digitalization have greatly helped the Chinese economy to expand around the world and have become powerful catalysts for Chinese economic development, providing it with new approaches to doing business. The article attempts to analyze this phenomenon and systematize the factors of China’s growth. Key aspects of the Chinese economy transformation are studied, such as GDP (in current and constant prices) and GNI per capita, manufacturing and trade, finance and capital. Special attention is paid to the global leadership role of China or/and the USA: Economy, Manufacturing, and International Trade. An in-depth comparative analysis of the economic growth indicators for China and the USA is based on extensive international statistical data. The author focuses on estimates of key indicators published by international bodies, such as the United Nations, UNCTAD, UNIDO, OECD, WTO and others. Various think tanks, independent agencies and other institutions such as McKinsey Global Institute, Primakov Institute of World Economy and International Relations RAS, Congressional Research Service (CRS), United States–China Economic and Security Review Commission, Committee on Foreign Investment in the United States (CFIUS) have been analyzing Chinese phenomenon of economic growth. Quantitative assessments of China’s economic growth are discussed. As shown, China plays a major role in the world economy and manufacturing. It is now the world’s first country by many economic indicators. In 2007, China became the world’s largest merchandise exporter. In 2009, it took the 1st place in manufacturing value-added output. Measured by purchasing power parity (PPP), in 2017 China stood as the world-largest economy in terms of GDP in current US dollars. Over the past decade, China has provided at least 30 percent of global GDP growth, while the United States was half as much. China is in the world’s top two for receiving and being the source of foreign direct investment (FDI). In 2020, China had 124 Global Fortune 500 companies compared to 121 American. At the same time, the US remains the world leader in many other quantitative indicators, for example in GDP at official exchange rates, innovation, research and development, finance, and services. It also ranks first in the world in terms of quality indicators of economic development. The author gives his vision of the China’s economic growth fundamental factors. Four of them are identified: a) low labor costs, b) well-designed legal environment for attracting foreign capital, c) massive FDI influx, d) imports of capital goods as well as modern Western technologies, including transfer of critical technologies, intellectual property and know-how (mainly through acquisition of Western firms). The general conclusion is that the reforms completely transformed the lives of Chinese people. China of the 1970s 80s and today’s China are two different economic, industrial, scientific, technical, socio-humanitarian entities.
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Carlos de Souza, Josiany, Sheida Mehrpour, Matheus Modolo Ferreira, Yves Luduvico Coelho, Gustavo De Castro Vivas, Denis Delisle Rodriguez, Francisco De Assis Santos, and Teodiano Freire Bastos-Filho. "Evaluation of Adverse Events Recorded in FDA/USA and ANVISA/Brazil Databases for Medical Devices: Defibrillator, Infusion Pump, Physiological Monitor, Pulmonary Ventilator and Ultrasonic Scalpel." Global Clinical Engineering Journal 4, no. 2 (June 1, 2021): 5–14. http://dx.doi.org/10.31354/globalce.v4i2.121.
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The use of medical technologies has grown steadily in all health fields, offering numerous benefits to patients. However, related adverse events, which may cause severe consequences for patients, also have increased. Technical factors and human aspects that cause dangers to patients may be related to the complexity of the devices, quality control in manufacturing, software used, maintenance procedures, materials, and mode of use. Thereby, our objective is to present the main alerts, dangers, and failures related to medical equipment and ways to attenuate them. For that purpose, we performed an analysis of adverse events reported for medical equipment in the Food Drugs Administration (FDA/USA) and the Brazilian Health Surveillance Agency (ANVISA) databases, since 2016. Finally, we classified the events into different categories, according to similarity. The results show a total of 3,100 cases registered in the FDA for six types of equipment at the study and 75 cases in ANVISA for two of these equipment. Based on the top ten health hazards (2016-2020) provided by the Emergency Care Research Institute (ECRI) we were able to understand which equipment most offers hazards and the main ways to mitigate them. We found that the risks are common to medical devices, therefore, it is crucial that there are preventative measures to avoid them, for example, training users to use the products, maintenance, improving quality, and reporting adverse events to manufacturers.
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Burdea, Grigore C. "Teaching Virtual Reality: Why and How?" Presence: Teleoperators and Virtual Environments 13, no. 4 (August 2004): 463–83. http://dx.doi.org/10.1162/1054746041944812.
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This article looks at the teaching aspects of virtual reality, as opposed to the use of virtual reality as a teaching tool (in virtual teaching environments). It is motivated by a perceived need for clarity, focus, and dialogue that are lacking within the VR community of developers, instructors, and end users. The market for visualization/3D computer graphics/simulations has seen a steady growth over the last decade. Yet, despite success stories in oil exploration, military training, car manufacturing, and other sectors, the VR curriculum has been fragmented and heterogeneous. The most longevity and success has been shown by programs that are designed to satisfy a societal need, such as the MOVES Institute at the Naval Postgraduate School (USA). The difficulty in adequately teaching VR may be related to the expense of setting up dedicated laboratories, and the lack of supporting textbooks in the 1990s. Yet such laboratories and books are key to gaining true understanding of the VR domain. An informal worldwide survey shows that only 3% of universities offer such courses, with half being in the USA. A listing of courses in Core (VR, VE technology) and Related (human factors, interface design, arts, architecture) areas is included in the Appendix. It is hoped that this article will spark a much-needed dialog within the VR community on ways to better teach VR to address societal needs.
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Jara Ruiz, Cristian, Cindy Navarrete Angulo, and Mariet Zapata Jiménez. "Estrés laboral y desempeño docente en los institutos de educación superior." Revista Científica Ciencia y Tecnología 23, no. 38 (April 30, 2023): 86–97. http://dx.doi.org/10.47189/rcct.v23i38.604.
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Actualmente es común escuchar a personas de nuestro entorno laboral sobre sus manifestaciones de estrés en sus ocupaciones diarias, debido a la exigencia de actividades, afectando a nivel personal, social y laboral. La presente investigación realiza una exploración de la presencia de estrés y su influencia en el desempeño laboral docente. El estudio considera un enfoque cuantitativo, correlacional de alcance transversal, que analiza la presencia de estrés y su repercusión en el desempeño docente en una Institución de Educación Superior, se empleó una muestra de 35 docentes, se aplicó el cuestionario (MBI) para determinar los niveles de estrés, incluyendo variables sociodemográficas, por su parte el desempeño laboral, se valoró recogiendo los resultados del proceso integral de evaluación docente correspondientes al período académico 2022. Los resultados muestran que no existen indicios de Burnout, sin embargo, el 67% de los docentes se encuentran en riesgo de padecer estrés, en cuanto al desempeño laboral los valores superan el 87%; la relación estadística muestra que el estrés no influye significativamente en el desempeño laboral docente, ni las variables sociodemográficas. Se concluye que los niveles de estrés presente no repercuten en sus funciones académicas, sin embargo, no es un factor apartado del entorno laboral.
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Mattedi, Milton, and Fernando José Armando Ribeiro. "REPRESENTATIVIDADE PARLAMENTAR E EFETIVIDADE DEMOCRÁTICA." Revista da Faculdade Mineira de Direito 21, no. 42 (July 16, 2019): 58–76. http://dx.doi.org/10.5752/p.2318-7999.2018v21n42p58-76.
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A democracia representativa é um dos elementos centrais da cultura jurídica e política ocidental. Todavia, como uma decorrência das suas próprias influências teóricas, ela termina por trazer intrínsecas algumas contradições estruturais e ideológicas. Entre tais elementos problemáticos figura, com destacada proeminência a questão da representatividade bem como o papel da técnica (em especial do econômico) em sua relação com o político. A representação parlamentar termina por se deslocar das necessidades da sociedade para a disputa de interesses individuais, excluindo-se o povo do centro das decisões. Neste estudo, por meio de revisão bibliográfica e incursões no direito comparado, procuramos demonstrar como os institutos democráticos requerem um constante labor reflexivo e crítico para que possam atender aos anseios de legitimidade e racionalidade. Assim, é não apenas ilusório mas perigoso acreditar que a democracia seja um conceito perfeitamente estabelecido. Verificamos que a representação não deve ser tida como um sistema que substitui, ainda que imperfeitamente, o exercício da democracia direta. A representatividade política é uma forma contínua de recriar e aprimorar o sistema democrático nos Estados contemporâneos. Para tanto trazemos algumas reflexões sobre diferentes institutos que têm sido utilizados em alguns Estados como aprimoramento da representação democrática.
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Carqueijó, Sérgio, Delfina Ramos, Joaquim Gonçalves, Sandro Carvalho, Federica Murmura, Laura Bravi, Manuel Doiro, Gilberto Santos, and Kristína Zgodavová. "The Importance of Fab Labs in the Development of New Products toward Mass Customization." Sustainability 14, no. 14 (July 15, 2022): 8671. http://dx.doi.org/10.3390/su14148671.
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The idea of developing Fab Labs (Fabrication Laboratories) was originated by Neil Gershenfeld of the Massachusetts Institute of Technology (MIT) Center for Bits and Atoms in 2006, where it signaled the start of a new era that is changing the world economy by breaking down the boundaries between the digital and physical worlds. The Portuguese Fab Labs are analyzed and a subsequent comparison with others European countries and in the USA was made. This comparison is based on aspects of the profile, the knowledge, the services, and the users. The survey was made by questionnaire, where the Portuguese version of it was adapted from another one disseminated at European level and in the USA, created in connection with a doctoral thesis in Italy. There are 25 active Fab Labs in Portugal, of which 16 responses were obtained and considered valid, so they represent the sample of our study. The results show that the Portuguese Fab Labs are in an embryonic phase with few associated or registered users. Portuguese Fab Labs have areas of work and investment capacity in machinery and technology similar to those of other European countries. However, in terms of turnover, there is a big difference between Portugal and some of the European countries, with American Fab Labs having completely different realities from the European ones. This work is relevant because it compares the Fab Labs of developed countries with those of Portugal. To overcome the difference in good practices existing in other countries, the Portuguese Fab Labs need: (1) better publicity, as well as more support for volunteer workers at Fab Labs, so that more ideas will appear and therefore more products; (2) the facilitation of the use of Fab Labs to have more volunteer workers, who must receive experimental courses, in order to make the best use of the available equipment; (3) evolution, from the current subtractive manufacturing to the additive manufacturing looking for innovation; (4) improved quality, ergonomics, and safety in the design of their own products; (5) and on the part of those responsible, therecognition, dissemination, and celebration of the best ideas that have turned into good products, in order to spread good practices.
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Medina Sánchez, Gustavo, Juan Antonio Ordóñez Partal, Rubén Dorado Vicente, and María Francisca Guerrero-Villar. "Surface Quality Optical Measurement of Part Inclined Planes Manufactured by FDM Technology." Key Engineering Materials 959 (October 6, 2023): 45–55. http://dx.doi.org/10.4028/p-agoj9v.
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Fused Filament Deposition (FDM) additive manufacturing technology allows the generation of three-dimensional parts by overlapping layers of an extruded polymer. The staircase effect caused by overlapping is well known and makes the manufactured parts have poor surface quality. This problem has been focused on by numerous works trying to optimize the surface quality by studying the process technological parameters or part geometry. Also, post-processing techniques have been developed that improve this roughness, but which involve an increase in manufacturing time and cost. In this work, a methodology to measure the roughness based on laser confocal microscopy is proposed. To evaluate the methodology, an experimental study is carried out that relates the surface roughness of parts manufactured with FDM with the building orientation and the layer height. The main objective of this study is to compare two roughness measurement methodologies: a mechanical measurement with a conventional contact roughness meter, and an optical measurement with a confocal microscope. The contact roughness meter provides a direct value of the roughness of the part wall profile, while the confocal microscope provides an image of the three-dimensional surface of the part wall, which must be processed. The data from the confocal microscope are evaluated with the Internet-based software Surface Metrology Algorithm Testing System (SMATS) developed by the National Institute of Standards and Technology (NIST) of the USA. The SMATS will provide an average value of the roughness of the analyzed surface. The test results with both methodologies are very similar, with an average difference of 5%. These results show the influence of the printed plane inclination angle on the roughness, which is higher for low values of the angle. It can also be seen that this influence decreases for low-layer heights.
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Bonizzato, Luigi, and Maria Clara Conde Moraes Cosati. "DIREITO ADQUIRIDO E NOVAS POSSIBILIDADES TEÓRICAS EM ÂMBITO DA SEGURIDADE SOCIAL CONSTITUCIONAL:." Revista da Faculdade Mineira de Direito 25, no. 49 (October 1, 2022): 23–48. http://dx.doi.org/10.5752/p.2318-7999.2022v25n49p23-48.
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Este Artigo jurídico, subdividido em duas partes textuais, aborda uma faceta do tema relativo ao direito adquirido, à expectativa de vida e ao aqui denominado direito ao planejamento de vida. Com base no exame de teorias e decisões judiciais clássicas e contemporâneas, além de em reformas legislativas e constitucionais que marcaram e continuam a marcar a história legislativo-constitucional brasileira, no texto faz-se uma abordagem delimitada dos institutos citados, com uma inclinação natural à sua aplicação e incidência na esfera da chamada seguridade social, em especial na esfera da previdência. A utilização de métodos dedutivo e indutivo, com marcos teóricos alicerçados no Direito Administrativo, Constitucional e na teoria do Direito, é feita de modo a trazer algumas novas possibilidades à situação concreta entendida como de alta relevância prática e teórica. Busca-se, também, avançar no conhecimento científico ligado às respectivas áreas do saber anteriormente citadas. Fontes bibliográficas, jurisprudenciais e legislativas amparam as conclusões e resultados finais, confirmados no texto.
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Bordin, Giuiana Martina, Prescila Mota de Oliveira Kublitski, Ádelin Olívia Lopes Joly Rodrigues, Pablo Guilherme Caldarelli, Luiz César Guarita-Souza, Juliana Schaia Rocha, and Marilisa Carneiro Leão Gabardo. "Conhecimento e práticas dos cirurgiões-dentistas para prevenção da endocardite infecciosa: uma revisão sistemática." Revista Sustinere 11, no. 2 (December 23, 2023): 471–96. http://dx.doi.org/10.12957/sustinere.2023.72730.
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A endocardite infecciosa é uma doença inflamatória que afeta o endocárdio e pode ter origem na cavidade oral, considerada a fonte mais frequente de microrganismos associados à bacteremia. O objetivo deste estudo foi avaliar o conhecimento e as práticas adotadas por cirurgiões-dentistas para a prevenção da endocardite infecciosa (EI). Foram incluídos estudos observacionais realizados com cirurgiões-dentistas avaliando seus conhecimentos e práticas para prevenção de EI, com base na diretriz da American Heart Association (AHA). Estudos com estudantes de odontologia ou outros profissionais, estudos nos quais não foi possível isolar AHA ou dados do dentista, estudos com endocardite não infecciosa, todos os tipos de revisões, cartas editoriais, resumos de conferências, estudos piloto, relatos de casos e séries de casos, opinião artigos, artigos técnicos e estudos de intervenção foram excluídos. As buscas foram realizadas no PubMed, Scopus, Web of Science, LILACS, BBO, CINAHL e literatura cinzenta. Dois revisores independentes avaliaram e participaram das etapas de seleção e elegibilidade até a extração dos dados. A lista de verificação do Joanna Briggs Institute foi usada para avaliar a qualidade metodológica e o risco de viés. Vinte e dois dos 1.085 estudos identificados foram incluídos. Doze estudos abordaram o conhecimento sobre EI e as práticas adotadas pelos profissionais para prevenir a morbidade. Sete estudos foram considerados de risco moderado de viés e 15 de baixo risco. Os resultados sugerem que o conhecimento e as práticas adotadas pelos cirurgiões-dentistas para prevenir a EI são insuficientes.
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Aralov, O. V., S. I. Vyunov, E. I. Yangirov, and A. M. Korolenok. "INVESTIGATION OF OIL PIPELINE EQUIPMENT FAILURE-FREE PERFORMANCE DEPENDING ON INTRODUCED QUALITY MANAGEMENT MECHANISMS." Petroleum Engineering 22, no. 1 (February 29, 2024): 140–49. http://dx.doi.org/10.17122/ngdelo-2024-1-140-149.
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The industry system for assessing the conformity of the main types of products used by Transneft has been operating since 2004 and is implemented on the basis of the Research Institute of Pipeline Transport of Transneft Research Institute. Conformity assessment shall be carried out for products of producers ensuring the technological processes of oil and petroleum products transportation and safety of facilities of oil trunk pipelines and petroleum product pipelines, including products operated under excess pressure of oil and petroleum products.As part of the implementation of this area of activity, the institute solves the following tasks:— expert examination of technical documentation of products;— participation in factory tests of products;— conducting tests of products on their own at the Research and Development Center of NII Transneft LLC (Ufa);— participation in the inspection of the production of products. In turn, Transneft has defined a list of the main types of products that are subject to mandatory conformity assessment and inclusion in the ORP Register, after which they are allowed to be used at Transneft’s hazardous production facilities, as well as developed its own industry regulatory documents of the type general technical requirements that take into account the uniqueness of the operating conditions of the equipment. Management of equipment reliability at different stages of the life cycle in an oil transportation enterprise represents a complex multilevel system of interrelated scientific, methodological and organizational and technical measures that directly or indirectly affect the reliability of equipment.Within the framework of the studies carried out by the specialists of Transneft Research Institute, more than thirty such measures were analyzed for direct or indirect impact on the reliability of equipment, including incoming control of equipment, factory, bench, resource, laboratory tests, production inspections, technical supervision of manufacturing, construction control of installation, diagnostics, maintenance, repairs, development of industry standards and other procedures. The variety of such processes makes up the system reliability of hazardous production facilities for pipeline transport of oil and petroleum products. The heterogeneity and sometimes redundancy of such processes negatively affect both operating organizations and equipment manufacturers.
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Romeiro Victor, David, Maria Eugênia Romeiro Victor, and Carlos Antonio de Souza Filho. "Hugh Hamptom Young e a Urologia moderna: uma história entrelaçada." Jornal Memorial da Medicina 5, no. 1 (July 1, 2023): 1–8. http://dx.doi.org/10.37085/jmmv5.n1.2023.pp.1-8.
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O Dr. Hugh Hampton Young (1870-1945) foi um médico americano que revolucionou o campo da Urologia, sendo reconhecido como um dos principais responsáveis por desenvolver e estabelecer a disciplina. As suas contribuições foram numerosas, incluindo a fundação do The Brady Urological Institute, o desenvolvimento de abordagens cirúrgicas pioneiras para patologias na próstata, a realização da primeira prostatectomia radical, a concepção de inovações no âmbito da Urologia Pediátrica e a realização de pesquisas sobre doenças venéreas. Além disso, fora do campo da Urologia, sua enorme curiosidade o levou a identificar o descobridor da anestesia geral por éter, uma contribuição histórica de enorme importância. Durante sua ilustre trajetória, entrou em contato com eminentes figuras dentro e fora da Medicina, tendo sido responsável pelo tratamento urológico do presidente americano Woodrow Wilson. Assim, para destacar a vida e legado de Hugh Young, uma revisão da literatura foi realizada, a primeira na língua portuguesa. Este esforço tem como objetivo levar seu legado a um público mais amplo, resgatar suas contribuições, inspirar as futuras gerações de profissionais médicos através de seu exemplo de profissionalismo e dedicação e recontar seu fascinante percurso de vida.
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Santana, Gislaine Aparecida, Romualdo Douglas Colauto, Cleberson Luiz Santos de Paula, and Gideão José Pinto Oliveira. "Teoria da Entidade versus Teoria dos Fundos: uma análise da evidenciação das demonstrações financeiras de uma organização sem fins lucrativos." Revista de Contabilidade da UFBA 7, no. 2 (November 13, 2013): 4–21. http://dx.doi.org/10.9771/rcufba.v7i2.6174.
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As associações sem finalidade lucrativa não possuem legislação específica para evidenciação de suas Demonstrações Financeiras (DFs) e por isso, são obrigadas a prepará-las conforme as normas para as organizações com finalidades lucrativas. Como a totalidade das rendas arrecadas pelas organizações sem fins lucrativos possui destinação específica, a utilização da teoria dos fundos para evidenciação das DFs pode tornar-se a mais adequada para este tipo de entidade. Assim, objetivou-se com este artigo demonstrar a evidenciação do Patrimônio Líquido em uma organização sem fins lucrativos sob a ótica da Teoria dos Fundos. A pesquisa caracterizada como exploratória, buscou converter as DFs de uma organização sem finalidade lucrativa, elaboradas de acordo com a Teoria da Entidade, em DFs elaboradas segundo os princípios da Teoria dos Fundos. O modelo de DFs utilizado no estudo encontra respaldo no Pronunciamento SFAS 117 do American Institute of Certified Public Accountants de 1993, o qual identifica se os recursos arrecadados apresentam restrições temporárias, permanentes ou nenhum tipo de restrição de uso pela organização. Os resultados mostram que a conversão permite ao usuário das informações contábeis identificar o patrimônio da organização de acordo com a sua finalidade e/ou restrição. Desse modo, a organização em estudo apresentou um patrimônio quase em sua totalidade com característica de restrição de uso. Além de revelar um superávit consolidado no Resultado do Exercício pelo modelo da Teoria da Entidade e um déficit quando segregado por fundos.
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Alcântara, Nelson Guedes de, and Sebastião Elias Kuri. "CCDM: um modelo de terceirização em laboratório de prestação de serviços." Production 8, no. 2 (December 1998): 141–49. http://dx.doi.org/10.1590/s0103-65131998000200001.
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O aumento nos custos de equipamentos de Pesquisa e Desenvolvimento - P&D além da necessidade de aperfeiçoamento constante da mão-de-obra especializada, tem sido uma das principais razões para o fechamento de vários laboratórios de P&D das indústrias. Entretanto, como a pesquisa e desenvolvimento são essenciais para novos produtos em um mercado cada vez mais competitivo, diversos centros de P&D foram criados nos países desenvolvidos. No Brasil, o primeiro centro de prestação de serviços criado pelo Estado está localizado no campus da Universidade Federal de São Carlos: o Centro de Caracterização e Desenvolvimento de Materiais - CCDM, um projeto de US$ 5 milhões. A principal diferença entre o CCDM e os existentes centros de P&D no Brasil, é a de que o CCDM é uma entidade sem fins lucrativos, deve ser auto-sustentável e presta serviços para as empresas, universidades e institutos de pesquisas. Este trabalho apresentará a experiência deste primeiro centro no Brasil. O crescimento contínuo e o sucesso deste centro - exemplo de terceirização - deve conduzir a um progresso na pesquisa e desenvolvimento na área de Ciência e Engenharia de Materiais.
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Salgado, Rômulo Dayan Camelo, Samara Silva Siqueira, and Tayse Camelo Salgado. "Qualidade de vida do estudante trabalhador: uma amostra dos discentes de cursos superiores do Instituto Federal do Piauí - Campus Floriano." Somma: Revista Cientifica do Instituto Federal de Educação Ciência e Tecnologia do Piauí 2, no. 2 (December 31, 2016): 35–46. http://dx.doi.org/10.51361/somma.v2i2.44.
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The daily life of many young people and adults living simultaneous situation to be a worker and university student finds intrinsic conditions in Brazil. In this sense, the objective of this study was to analyze the quality of life related to health according to the questionnaire SF-36 student workers of the higher courses of the Federal Institute of Piauí, Floriano campus. The methodology was characterized as a descriptive, exploratory, qualitative approach with a sample of 100 (47.39%) students workers entering in 2013 and 2014, the 211 (100%) students enrolled in the upper courses of Degree in Biological Sciences, Degree in Mathematics, Analysis and Systems Development. The dominance results pointed to males, with 51%, and an average age of 24.20 years (SD = 2.5, median = 24). As to the characterization of the quality of life, the average for all areas was 68.4. The lowest recorded score was related to pain (47.1), and the highest was for emotional aspects (79.3). The lowest scores were for the domains social, pain, vitality,and general health, more significantly for the last three. The areas with the lowest scores were: general health (63.9), pain (47.1),and vitality (56.7),and the mean between them was 55.9. It was considered the end of thestudy this the quality of life related to health of students working and studying in undergraduate courses of Federal do Piauí Institute campus Floriano, is classified as being regular, inferring that work and study concurrently conducted interfere reasonably quality life of young students, and can harm your performance in activities related to learning.
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Rengarten, G. A. "Introduction and breeding of shadbush in Russia and abroad." Plant Biotechnology and Breeding 6, no. 2 (November 13, 2023): 27–36. http://dx.doi.org/10.30901/2658-6266-2023-2-o2.
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Shadbush is one of the underutilized berry crops. Originally, it was an ornamental crop, but now it is increasingly used as a food crop. Numerous species of shadbush belong to the genus Amelanchier Medik.; wild species grow in North America, Europe, as well as in Western and Eastern Asia, and each region has different species composition. The year of 1590 marked the beginning of introduction of wild shadbush species with the most valuable features to other countries. In the 19th century, the introduction of shadbush became most popular. In 1800, shadbush breeding was launched in Canada, and then in the USA. In 1937, the production of commercial varieties was established. At present, in Russia, the most productive work on introduction and breeding of shadbush is carried out in Michurinsk (All-Russian Scientific Research Institute of Horticulture named after I.V. Michurin), Novosibirsk (Central Siberian Botanical Garden of SB RAS), and Moscow (N.V. Tsitsin Main Botanical Garden). Unfortunately, the assortment of shadbush varieties in Russia is still quite limited and is represented by only two varieties. In recent years, the development of methods of shadbush clonal micropropagation has been underway, which makes it possible to obtain planting material on an industrial scale and accelerate the reproduction of rare varieties.
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Menchik, Jaubert de Castro, Gabriela Brum de Deus, and Renato Xavier Coutinho. "Análise das produções acadêmicas sobre Educação Física e Currículo Integrado para a Educação Profissional entre 2009 a 2022." Revista Prática Docente 9 (April 6, 2024): e24004. http://dx.doi.org/10.23926/rpd.2024.v9.e24004.id734.
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O Ensino Médio Integrado (EMI) é uma modalidade desenvolvida nos Institutos Federais (IFs) que relaciona os conteúdos do ensino básico com o profissionalizante. Assim, este ensaio analisou produções acadêmicas dentro da área da Educação Física (EF), do EMI e dos IFs a partir dos estudos publicados na Biblioteca Digital Brasileira de Teses e Dissertações e no Portal de Periódicos da CAPES no período de 2009 a 2022. Esta pesquisa possuí viés qualiquantitativo, de caráter documental e cienciométrico, traçando um panorama, as implicações nos currículos e nas práticas pedagógicas da EF. Os resultados demonstraram que os percursos da EF nos IFs e as contribuições do EMI dentro da disciplina apresentam caráter relevante. Nota-se que a EF busca sua identidade dentro do EMI, pois, os trabalhos apontam que há uma “esportivização” relativa aos conteúdos. Assim, constata-se a necessidade de ampliar os estudos sobre as possibilidades metodológicas para alcançar a integralidade da educação proposta pelo EMI.
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Lima, Adriano Gouveia, and Rubem Alexandre Maia Fontes. "ANÁLISE SOBRE A POSSIBILIDADE DA CARACTERIZAÇÃO DA INIMPUTABILIDADE PENAL DA PESSOA COM TRANSTORNO BIPOLAR TIPO I." Revista Jurídica 22, no. 2 (August 24, 2023): 127–37. http://dx.doi.org/10.37951/2236-5788.2022v22i2.p127-137.
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Este trabalho acadêmico propôs-se a articular uma análise referente a aspectos psicológicos e jurídicos que dizem respeito ao instituto da inimputabilidade penal no Direito brasileiro vigente. Não se buscou exaurir a temática; antes, almejou-se apresentar um panorama metodologicamente orientado sobre o tema. A diretriz do trabalho seguiu o método de pesquisa científica qualitativa na modalidade bibliográfica. Assim, buscou-se compulsar detidamente a literatura acadêmica especializada da Psicologia e das Ciências Jurídicas para promover uma apropriada articulação teorética que permita melhor pensar os institutos. A pesquisa inicia-se pela apresentação do sentido nuclear da inimputabilidade por transtorno mental. Passa, então, para uma análise que tem por partida o sentido de doença mental no Código Penal. Ao final, vem a revelar o sentido de transtorno bipolar e sua consideração pelo Direito Penal. O resultado consubstancia-se em um texto que anseia contribuir para a comunidade acadêmica pela proposta do didatismo inerente à metodologia adotada.
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Ferreira Almeida, Thiago. "Países Emergentes e a Mudança no Paradigma dos Investimentos Internacionais." Revista da Faculdade de Direito da Universidade Federal de Uberlândia 50, no. 2 (July 12, 2023): 175–200. http://dx.doi.org/10.14393/rfadir-50.2.2022.64327.175-200.
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O artigo objetiva reconhecer a existência de um novo paradigma dos investimentos internacionais. Esse paradigma, iniciado a partir do século XXI, decorre do reposicionamento dos países emergentes. O trabalho está estruturado em duas partes. Primeiro, primou-se pelo reconhecimento de um grupo específico de países emergentes, que apresentam importância econômica, política, jurídica e nas relações internacionais. Esse grupo corresponde aos onze países do G20 Financeiro, que se qualificam como o G11. Em um segundo momento, analisou-se o reconhecimento de um novo paradigma dos investimentos internacionais, pautados por acordos bilaterais mais balanceados, no nível bilateral, novos acordos regionais abrangentes, a envolver temas de liberalização comercial e de investimentos e, principalmente, pela liderança das economias emergentes no G20 Financeiro e nas Conferências Ministeriais da OMC sobre facilitação e promoção do investimento. Tais alterações no paradigma repercutem no Direito Internacional do Investimento, a incorporar a necessidade de um debate contemporâneo por uma reforma em seus institutos em atendimento ao maior reposicionamento das economias emergentes no sistema internacional.
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Lopes, Jaqueline Peixoto, Emanoele Anastácia da Silva Araujo Melo, Frederico Barreto Kochem, Ana Carolina Nader Vasconcelos Messias, Marco Orsini, Victor Hugo do Vale Bastos, Julio Guilherme Silva, Cristiane Sousa Nascimento Baez Garcia, Luciana Moisés Camilo, and Mauricio de Sant Anna Junior. "Função cognitiva, comportamento alimentar e neuroimagem em obesos: uma revisão sistemática." Fisioterapia Brasil 24, no. 4 (September 6, 2023): 506–18. http://dx.doi.org/10.33233/fb.v24i4.5528.
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Introdução: A obesidade é considerada uma desordem multifatorial influenciada por fatores hormonais, dietéticos, comportamentais, emocionais, atencionais e controle cognitivo que interferem no equilíbrio ingestão e gasto energético. A influência da obesidade no declínio cognitivo e prejuízos a funções e estruturas cerebrais além de sua associação com processos neurodegenerativos precoces tem sido observada. Objetivo: Esta revisão buscou identificar as áreas corticais mais ativadas em indivíduos obesos, investigar a existência de comprometimento cognitivo e a possível interferência no comportamento alimentar. Além disso, buscou-se identificar os métodos de neuroimagem mais utilizados para avaliação desses processos. Buscou-se estudos publicados 2006 e 2021. Foram pesquisadas as bases de dados indexadas PUBMED, LILACS e SCIELO. Foram selecionados estudos observacionais que comparassem indivíduos obesos (IMC > 30 kg/m²) e não obesos. Foi utilizado o Quality Assessment of Observational Cohort and Cross-Sectional Studies da National Heart, Lung and Blood Institute (NIH) para análise de qualidade metodológica. Resultados: Foram reportados 22.484 títulos. Após a aplicação dos critérios de elegibilidade, foram selecionados 154 artigos. Desses, onze foramincluídos para análise nesta revisão. Nesta análise, diferenças foram encontradas quanto ao tempo de reação, acurácia ou áreas cerebrais inativadas durante os testescognitvosou estímulos com figuras de comida entre os grupos estudados. Conclusão: Mudanças estruturais compatíveis com prejuízos na performance cognitiva a longo prazo foram identificadas, assim como alterações estruturais e funcionais que podem auxiliar o entendimento de comportamento alimentar compulsivo presente em indivíduos obesos.
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Butovskaya, Marina L., Alexandra P. Buzhilova, Elena Z. Godina, Kaushik S. Bose, Mariya V. Dobrovol'skaya, Andrei I. Kozlov, Mariya B. Mednikova, Irina A. Khomiakova, Anastasiya T. Agdzhoyan, and Taisiya A. Syutkina. "The review of the IX International scientific conference, dedicated to the memory of academicians V.P. Alexeev and T.I. Alexeeva." Moscow University Anthropology Bulletin (Vestnik Moskovskogo Universiteta. Seria XXIII. Antropologia), no. 4 (November 21, 2022): 137–49. http://dx.doi.org/10.32521/2074-8132.2022.4.137-149.
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IX International Scientific Conference dedicated to the memory of academicians V.P. Alexeev and T.I.Alexeeva, was held in Moscow from October 17th to October 20th, 2022. This time, the leading organizer of the event was the Institute of Ethnology and Anthropology N.N. Miklukho-Maclay of the Russian Academy of Sciences, although as in the previous Alexeevsky readings, the Scientific Research Institute and the Museum of Anthropology named after D.N. Anuchin Moscow State University and the Institute of Archaeology of the Russian Academy of Sciences were actively involved in it’s organization. Despite the fact that this time all presentations were held online, it should be noted that the quality of papers, as well as the activity of the participants of the event, turned out to be at the highest level. 90 papers were presented by 120 authors from Russia, Armenia, Belarus, India, Poland, Mongolia and Great Britain. Russian speakers represented scientific institutions from Moscow, Krasnodar region, Nizhny Novgorod, Kemerovo, Tyumen and Rostov regions, Volgograd, Ufa, Magadan, Pskov and St.Petersburg. At the opening of the conference, the names of the winners of the V.P Alexeev and T.I.Alexeeva Award in the field of interdisciplinary research in archaeology and anthropology in 2022 were announced. They were DSci Balabanova Aria Afanasievna and PhD Pererva Evgeny Vladimirovich. We sincerely congratulate our Volgograd colleagues and wish them new discoveries and scientific achievements. The topics of the meeting reflected the main modern trends in biological anthropology and related disciplines and included the Russian-Indian roundtable “Children’s Growth and Health”, conducted in English, as well as the sections “Human Evolution and Behavior: Modern Approaches and Perspectives”, “Modern Problems in Applied Anthropology”, “Adaptation Processes in the Indigenous People from the Modern Human Populations”, “Sports Anthropology”, “Modern Issues of the Ethnogenesis of Ancient Populations”, “Factors of the Population Variability – New Approaches and Perspectives of Research”, “Bioarchaeological Reconstruction – Perspectives and Limits of the Method”, “Paleoecological Aspects of Human Studies in the Context of Modern Biogeochemical Research”, “Demography as a tool for analyzing the stress resistance of a population in the past and present”.
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Barbon, Beatriz Ribeiro Lopes, and Luiz Alberto Pereira Ribeiro. "A atuação das partes no processo civil: uma análise sob a ótica do esclarecimento kantiano." Revista de Argumentação e Hermeneutica Jurídica 8, no. 2 (February 15, 2023): 18. http://dx.doi.org/10.26668/indexlawjournals/2526-0103/2022.v8i2.9126.
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O presente artigo busca refletir acerca da atuação das partes e os princípios da cooperação e da boa-fé no Código de Processo Civil brasileiro especificamente sob a ótica do conceito de esclarecimento kantiano. Para tanto, serão analisados trechos da obra de Immanuel Kant que tratam sobre o tema do esclarecimento, juntamente com obras e artigos científicos sobre princípios do processo civil e alguns de seus institutos. Através do método analítico *dedutivo, busca-se realizar uma interpretação que enfatiza a autonomia das partes na solução da lide, a fim de que obtenham decisões de mérito efetivas e satisfatórias. Inicialmente, apresenta-se a concepção do esclarecimento kantiano e suas implicações no direito; em seguida, são expostos os princípios da cooperação e da boa-fé, interpretando-os como sendo verdadeiros indutores de uma “atuação esclarecida” das partes. Por fim, argumenta-se como esse conceito kantiano é relevante para a consecução dos objetivos processuais de forma mais célere e satisfatória aos litigantes e seus patronos. Nessa linha, conclui-se que ideia de autonomia pode ser corroborada pelo direito e ainda auxiliá-lo, na medida em que a busca pela solução mais adequada do litígio depende significativamente da atuação dos sujeitos processuais.
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Bose, A. "A Review of: “WORLD CONFERENCE ON POWDER METALLURGY” 2-6 July 1990, Wembly Conference Center, London, UK The Institute of Metals 1 Carlton House Terrace, London SW1Y 5DB, UK, and The Institute of Metals North American Publications Center Old Post Road, Brookfield, VT 05036, USA." Materials and Manufacturing Processes 7, no. 3 (January 1992): 469–72. http://dx.doi.org/10.1080/10426919208947433.
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Halim, Paisal, Syamsiah Badruddin, Muhammad Ikhsan Setiawan, and Abdul Talib Bon. "G20, Social Science, Environmental Science, Economics, Econometrics and Finance Research Trend." IJEBD (International Journal of Entrepreneurship and Business Development) 6, no. 2 (March 31, 2023): 381–86. http://dx.doi.org/10.29138/ijebd.v6i2.2240.
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The G20 is a multilateral cooperation forum consisting of 19 major countries and the European Union (EU) which has a middle to high income class, developing countries to developed countries. G20 members consist of countries from various regions of the world. United States, Canada, Mexico, Argentina, Brazil, United Kingdom, Germany, Italy, France, Russia, South Africa, Saudi Arabia, Turkey, China, Japan, South Korea, India, Indonesia, Australia and the European Union. In the G20 Indonesia became one of the 5 strongest economies in Asia Pacific, including: (1) China GDP 14.72 trillion US dollars (2020) Area 9.597 million km2 Population 1.402 billion people (2020) China's largest economy from manufacturing, services, and agriculture. SCOPUS.COM analyze search results, Social Science, Environmental Science, Economics, Econometrics and Finance 22,997 documents result since 1974 to 2022, all field article. So today in good trend of research and publication in Social Science, Environmental Science, Economics, Econometrics and Finance. Compare top 15 affiliations, dominant affiliations from China and Malaysia, the best 3 affiliations are Beijing Institute of Technology 318 documents; Xi'an Jiaotong University 227 documents and Southwestern University of Finance and Economics 211 documents. Still no Indonesia research institution in top 15 of the list. Compare top 15 affiliations, the best 3 countries are China, USA and UK. In ASIA and ASEAN, Indonesia under China, Pakistan and Malaysia. So this is real challenge for Indonesia research institution to expand their research in Social Science, Environmental Science, Economics, Econometrics and Finance, trend in 2010-nowadays
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Mota, Michelle Katiuscia Melo, and Elaine Aparecida Takamatu Watanabe. "ENSINO REMOTO EMERGENCIAL E OS DESAFIOS PARA DOCÊNCIA." Revista Valore 5 (July 2, 2021): 39–47. http://dx.doi.org/10.22408/reva50202088539-47.
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A pandemia causada pelo novo coronavírus adquiriu grandes proporções e seu impacto na sociedade acadêmica culminou em suspensão de aulas presenciais e a implantação de uma nova modalidade de ensino mediado por tecnologia digital: o Ensino Remoto Emergencial. Metodologia: Trata-se de uma revisão integrativa, sobre as dificuldades e desafios dos docentes no manejo do ensino remote, Apresentando como pergunta norteadora: Quais os desafios e dificuldades enfrentados pelos docentes durante o planejamento e uso do ensino remoto no periodo da pandemia COVID-19 ?, o levantamento dos artigos se deu nas bases de dados como: Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), Institute of Education Sciences (Eric) , assim como uma busca de textos cientificos pelo acesso às revistas eletrônicas disponíveis no portal de periódicos CAPES. Resultados :Foram encontrado no total 24 artigos, em seguida foi feita uma pré seleção a partir da leitura na íntegra dos resumos, a qual foram selecionado 8 artigos cujo conteúdo contemplaram os descritores, palavras chave. Considerações finais: estudo conclui que o novo modelo provocou vários desafios incluindo sentimentos de angústia, inquietações, inseguranças, dúvidas e sobrecarga de trabalho a categoria docente. Por outro lado o novo contexto laboral corrobora para aquisição de novas experiências, novas estrátegia metodológicas que direcionam a aprendizagem dos professores.Palavras-chave: Ensino Remoto, Pandemias, Docente
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Sampaio, Luciana Dominici, and Liliane Barbosa Amorim. "O Ensino Médio Integrado nos Institutos Federais de Educação, Ciência e Tecnologia e a formação humana integral." Revista Espaço Pedagógico 30 (April 18, 2023): e14341. http://dx.doi.org/10.5335/rep.v30i0.14341.
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Este artigo propõe refletir sobre os fundamentos históricos e políticos do Ensino Médio Integrado (EMI) e sobre a dualidade estrutural na educação brasileira, tem o objetivo de discutir a relevância da formação humana integral, tendo o trabalho, a ciência, a cultura e a tecnologia como eixos estruturantes dessa formação. Tem como paradigma o materialismo histórico-dialético numa perspectiva de emancipação humana da sociedade. Nas análises, vale ressaltar que, por mais que a sociedade capitalista não tenha interesse no EMI, é esse o percurso que devemos percorrer e insistir, em nome de uma educação mais justa, igualitária e para todos e com a clareza que tanto a educação quanto o trabalho enquanto categorias estruturantes da sociedade continuarão sendo objeto de disputas e embates ideológicos. O grande desafio é lutar para garantir que a ampliação e qualificação do EMI continue acontecendo e que se identifique com o dinamismo social da classe trabalhadora.
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Shirase, Keiichi. "Special Issue on Modeling and Simulation of Cutting Process." International Journal of Automation Technology 4, no. 3 (May 5, 2010): 213. http://dx.doi.org/10.20965/ijat.2010.p0213.
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In the 5 decades-plus since the first numerical control (NC) machine tool was demonstrated at the Massachusetts Institute of Technology in Boston, MA, USA, advances such as high-speed, multi-axis and multi-tasking machine tools have been introduced widely to achieve high quality and productivity in machining operations. In order to handle these sophisticated machine tools freely and effectively, sophisticated NC programs are conventionally required in advance for problem-free machining. Computer simulation and optimization of cutting processes by considering process physics, machine tool dynamics and kinematics and process constraints are helpful in the strategic process planning operation and useful in preparing sophisticated NC programs. However, challenges and models quantitatively predicting cutting process performance remain to be developed. Topics of interests in this special issue include but are not limited to - machining process modeling - machine tool dynamics modeling - cutting force, cutting temperature, surface roughness, etc., prediction - machining stability prediction - simulation-based machining-process diagnostics - optimization using machining simulation The review paper and ten research works accepted are related to state-of-the-art modeling and simulation applicable to the machining and manufacturing domains. Besides traditional machining, nontraditional machining such as laser machining for micromachining have been explored. Also the machining of calcium polyphosphate (CPP) for tissue engineering applications has been investigated. The articles in this special issue are sure to prove interesting, informative, and inspiring to our readers on advances in cutting process modeling and simulation. Finally, we thank the authors, reviewers, and editors for their invaluable contributions and generous efforts in enabling this issue to be published.
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Saini, Rajkumar, Ranu Sewada, and Aaryan Arora. "Current Challenge and Limitations in Quantum Computation." Journal of Nonlinear Analysis and Optimization 13, no. 01 (2023): 26–35. http://dx.doi.org/10.36893/jnao.2022.v13i02.0026-035.
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This paper reviews various engineering hurdles facing the field of quantum computing. Specifically, problems related to decoherence, state preparation, error correction, and implement ability of gates are considered. Computer computation is very advanced computers used in recent days for various applications, including cryptography, optimization problems, financial modelling, route and traffic optimization, manufacturing drug, chemical research, batteries, simulation of quantum systems, and even machine learning. In a quantum computer, two qubits can also represent the exact same four states (00,01,10 or 11). It’s an exciting field with lots of potential. But it faces lots of challenges and problems like maintaining qubits, interaction with the environment can cause decoherence. However, the adventure to harness the enormous power of quantum computer systems is packed with challenges and boundaries. In this discussion, we can embark on an exploration of the current boundaries that researchers and engineers face within the world of quantum computing, losing mild on the complexities and constraints that ought to be overcome to fully free up its ability. Reacher’s are working on error correction techniques to address this issue and make quantum computations more reliable. It’s fascinating area of ongoing research. In recent development in quantum computing on 4 October 2022 The Royal Swedish Academy of Sciences has decided to award the Nobel Prize in Physics 2022 to Alain Aspect (Institute d’Optique Graduate School – Université Paris-Saclay and École Polytechnique, Palaiseau, France ), John F. Clauser ( J.F. Clauser & Assoc., Walnut Creek, CA, USA ) Anton Zeilinger University of Vienna, Austria“for experiments with entangled photons, establishing the violation of Bell inequalities and pioneering quantum
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Silva, Laura Oliveira, and José Cristiano Leão Tolini. "ATIVISMO JUDICIAL E CRIAÇÃO JURÍDICA: existe o direito do legislador e o direito do juiz?" Revista Jurídica 23, no. 1 (September 18, 2023): 1–17. http://dx.doi.org/10.37951/2236-5788.2023v1i1.p1-17.
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O presente artigo objetiva abordar a questão do ativismo judicial contextualizado a partir da análise de recentes casos de grande repercussão no Brasil, que sugerem a ocorrência de ativismo. Para tanto, define ativismo judicial; traz uma breve compreensão dos institutos do recurso extraordinário (RE) e da repercussão geral (RG); realiza a análise do recurso sobre o direito de transexual ser tratado conforme identidade de gênero ante à polêmica em torno dos banheiros públicos; e da Ação Direta de Inconstitucionalidade por Omissão (ADO) 26 somada ao Mandado de Injunção (MI) 4733, em que o STF reconheceu a omissão do Congresso Nacional por não ter ainda editado uma lei que tornasse crime os atos de homofobia e de transfobia. O método empregado na realização desta pesquisa foi o dialético-argumentativo, operacionalizado por ampla pesquisa bibliográfica e documental realizada em artigos, doutrinas e entendimentos jurisprudenciais pertinentes à temática abordada. Concluiu-se que os magistrados também podem exercer uma posição ativa, inovando o ordenamento jurídico, desde que o seu comportamento seja imprescindível no caso concreto. É imprescindível que o juiz também possa inovar o ordenamento jurídico quando essa postura for indispensável, sobretudo quando a matéria em discussão é fundamental para o interesse da sociedade e a proteção legislativa é insuficiente, inexistente ou injusta.
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Da Costa, Alexandre Menezes, and Ricardo Jorge da Cunha Costa Nogueira. "FILOSOFIA LEAN E A FERRAMENTA VSM: UMA ANÁLISE SOBRE A UTILIZAÇÃO DA FILOSOFIA E DA FERRAMENTA NAS TESES E DISSERTAÇÕES PRODUZIDAS NAS INSTITUIÇÕES DE ENSINO SUPERIOR PÚBLICAS BRASILEIRAS." REVISTA FOCO 16, no. 7 (July 7, 2023): e2320. http://dx.doi.org/10.54751/revistafoco.v16n7-018.
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O Lean Thinking, ou Pensamento Enxuto, é uma filosofia de trabalho em que se aplicam determinados princípios, para que se possa obter redução de perdas e melhoria nos processos organizacionais, visando ao aumento da produtividade e da eficiência. O presente artigo tem por finalidade analisar qual o impacto que a filosofia Lean e a ferramenta Value Stream Mapping (VSM) exerceram sobre a produção de teses e dissertações nas Instituições públicas de ensino superior no Brasil, nos últimos 10 (dez) anos, de forma a contribuir para que o universo acadêmico e sociedade em geral possam analisar e avaliar a necessidade de utilização destes recursos, como meio para obtenção de melhoria em seus processos. Para o alcance deste objetivo, quanto à abordagem, a pesquisa se caracterizou como quantitativa. Os procedimentos técnicos utilizados foram baseados em pesquisas nos sites e portais da área e na revisão da literatura, ocorridas em duas fases distintas: sendo a primeira baseada no levantamento e analise dos dados, culminando com a formatação do texto para que a leitura e o entendimento ficassem acessíveis ao leitor. Neste sentido, o resultado obtido foi a constatação de que no total de 61 (sessenta e uma) instituições pesquisadas, entre Institutos de Tecnologia e Universidades, somente 12 (doze) apresentaram em seus programas de pós-graduação Stricto Sensu, no curso de Engenharia de Produção, teses e dissertações produzidas com a temática do Lean Thinking, Lean Manufacturing e a ferramenta VSM. Neste contexto, observou-se uma maior concentração de pesquisas realizadas com este tema nas regiões Sul e Sudeste e de menor produção nas regiões Norte, Nordeste e Centro-Oeste. Este fato evidencia haver ainda um vasto campo de oportunidades de pesquisa a ser exploradas, neste tema, considerando o notório potencial industrial e tecnológico de algumas regiões, a partir dos números apresentados neste estudo.
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Chaves, Joel Ricardo Ribeiro de, and SAMYRA HAYDÊE DAL FARRA NASPOLINI. "OS DIREITOS DA PERSONALIDADE DA PESSOA JURÍDICA NA SOCIEDADE DA INFORMAÇÃO." Revista Brasileira de Direito Civil em Perspectiva 9, no. 1 (August 1, 2023): 62. http://dx.doi.org/10.26668/indexlawjournals/2526-0243/2023.v9i1.9673.
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Amparado na metodologia da pesquisa documental e bibliográfica, buscou-se desenvolver uma análise dos potenciais impactos e transformações que a Sociedade da Informação pode ocasionar aos direitos da personalidade da pessoa jurídica. Observou-se que a Sociedade da Informação, momento histórico, em rede e globalizado, espelha uma profunda mudança na organização da sociedade e da economia, com implicações às estruturas e às dinâmicas outrora consolidadas. Nesse sentido, os direitos da personalidade, próprios da pessoa em si e que albergam também suas projeções, perpassam por uma alimentação e transformação contínua, com novos direitos ou redesignação de seus conteúdos e significados decorrentes de uma ciência e prática jurídica consciente do desenvolvimento e das transformações histórico, social, econômico, político etc., potencializados pelo desenvolvimento tecnológico e pelo momento histórico vivenciado. Assim, reconhecendo-se a aplicabilidade da tutela dos direitos da personalidade à pessoa jurídica, as transformações causadas pela Sociedade da Informação demandam a reavaliação e adequação constante dos institutos jurídicos, sempre com os olhos voltados para o futuro e sem apego a um dogmatismo histórico, com vistas a viabilizar o máximo de desenvolvimento e impacto positivos das inovações tecnológicas ao mesmo tempo em que se adapta e resguarda direitos e garantias consolidados ao longo da História.
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De Soares, Henrique Martins, and Cristiano Sordi Schiavi. "COVID-19 e Responsabilidade Social Corporativa: os posicionamentos dos empresários negacionistas da pandemia." Revista Organizações em Contexto 19, no. 37 (June 21, 2023): 297–328. http://dx.doi.org/10.15603/1982-8756/roc.v19n37p297-328.
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O objetivo do presente estudo é analisar as diferenças existentes entre comunicação e prática de RSC dos empresários negacionistas durante a pandemia da COVID-19. O estudo em questão possui caráter qualitativo, utilizando-se da técnica de coleta de dados documental e da análise de conteúdo. Inicialmente, realizou-se uma pesquisa exploratória para identificar os empresários negacionistas na pandemia, sendo selecionados três a partir de reportagens publicadas nos principais veículos jornalísticos do Brasil. Na análise de dados, foram consideradas as informações presentes no site institucional, na mídia digital da empresa e dos próprios empresários, e nas matérias jornalísticas. Na análise dos resultados percebeu-se: posicionamento negacionista no discurso dos empresários; falta de clareza quanto a segurança do local de trabalho durante a pandemia; desrespeito às recomendações de distanciamento social nas ações das empresas; violação de direitos humanos, como direito à vida e à saúde, nas declarações e ações dos empresários; influência política prejudicial ao desenvolvimento de políticas públicas; posicionamento quanto à RSC limitadas a ações filantrópicas. A partir da análise, concluiu-se que as empresas, e seus respectivos empresários, apresentam ações sociais limitadas à filantropia e descumprem os pressupostos de RSC descritos pelos principais institutos e normas.
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Huseynova, E. "Evaluation of Drought Resistance of Soft Wheat (Triticum aestivum L.) Genotypes in Field Conditions by Turgorometric Method." Bulletin of Science and Practice, no. 3 (March 15, 2023): 109–14. http://dx.doi.org/10.33619/2414-2948/88/13.
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In the research work, 32 were local (materials of the “Cereals and Legumes” Department of the Institute of Genetic Resources of ANAS) and 25 were introduced by CIMMYT (International Center for Maize and Wheat Improvement), a total of 57 (Triticum aestivum L.) studied the effect of stress factors on physiological processes of autumn soft wheat genotypes under field conditions, especially drought on the water retention capacity of leaves. Water retention capacity is considered as a very valuable trait of wheat genotypes and is evaluated as resistance to drought stress. As a result of the study, among 57 wheat genotypes, the following genotypes were classified as I- drought resistant (Gobustan (st.) (AZE), Bol wheat (AZE), Grekum75/50 (AZE), Taraggi (AZE), Akinchi84 (AZE), Giymetli 2/ 17(AZE), Sheki 1(AZE), Tale38 (AZE),TX96V2847(US-TX), Arlin/Yuma (USA-KSU), MV Dalma (HU-MV), Desin (RO-FL), Duopebusa (MOL ), SG-S1915 (CZ), U1254-7-9-2-1/TX86A5616//Rina-6)(TCI), II- moderately resistant to drought (Arzu (AZE), Zardabi (AZE), Durdane (AZE), Mirbashir128 (AZE), Nurlu99 (AZE), Ruzi84 (AZE), Aran (AZE), Murov2(AZE), GobustanS2 (AZE), Starshina (RUS-KR), MV06-02 (HU-MV), Gerek (TR- ESK), Gloria (RO-FL), Bezostaya1(TR-ESK), LC924/Petja (BG-SAD), Sonmez (TR-ESK), Dalnitskaya (UKR)) and III- drought (Birlik (AZE), Gurgane 1 (AZE), Karabakh10 (AZE), Parzivan 1(AZE), Parzivan 2(AZE), Azeri (AZE), Saba (AZE), Zubkov (KYR), Steklovidnaya 24 (KAZ)) are grouped as sensitive.
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Grupp, Stephan A., Shannon L. Maude, Susana Rives, Andre Baruchel, Michael W. Boyer, Henrique Bittencourt, Peter Bader, et al. "Updated Analysis of the Efficacy and Safety of Tisagenlecleucel in Pediatric and Young Adult Patients with Relapsed/Refractory (r/r) Acute Lymphoblastic Leukemia." Blood 132, Supplement 1 (November 29, 2018): 895. http://dx.doi.org/10.1182/blood-2018-99-112599.
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Abstract BACKGROUND Tisagenlecleucel is an FDA approved chimeric antigen receptor (CAR)-T cell therapy that reprograms T cells to eliminate CD19+ B cells. ELIANA (NCT02435849) is a phase 2 pivotal study of tisagenlecleucel in pediatric/young adult patients (pts) with CD19+ r/r B-cell acute lymphoblastic leukemia (ALL), the first global trial of a CAR-T cell therapy. The primary objective was met, with an overall remission rate (ORR) of 81% (complete remission [CR] + CR with incomplete blood count recovery [CRi]). Here we present an update of ELIANA, with additional pts and additional 11 mo follow-up from the previous report (Maude et al. N Engl J Med 2018). METHODS Eligible pts were aged ≥3 y at screening and ≤21 y at diagnosis and had ≥5% leukemic blasts in bone marrow. Tisagenlecleucel was centrally manufactured at 2 sites (Morris Plains, NJ, USA and Leipzig, Germany) by lentiviral transduction of autologous T cells with a vector encoding for a second generation 4-1BB anti-CD19 CAR and expanded ex vivo. Tisagenlecleucel was provided to pts at 25 study centers in 11 countries on 4 continents using cryopreserved apheresed mononuclear cells, central production facilities, and a global supply chain. The primary endpoint, ORR within 3 mo and maintained for ≥28 d among infused pts, was assessed by an independent review committee. Secondary endpoints included duration of remission (DOR), overall survival (OS), safety, and cellular kinetics. RESULTS As of April 13, 2018, 113 pts were screened and 97 enrolled. There were 8 manufacturing failures (8%) and 10 pts (10%) were not infused due to death or adverse events (AEs). Following lymphodepleting chemotherapy in most pts (76/79; fludarabine/cyclophosphamide [n=75]), 79 pts were infused with a single dose of tisagenlecleucel (median dose, 3.0×106 [range, 0.2-5.4×106] CAR-positive viable T cells/kg), and all had ≥3 mo of follow-up or discontinued earlier (median time from infusion to data cutoff, 24 mo [range, 4.5-35 mo]). Median age was 11 y (range, 3-24 y); 61% of pts had prior hematopoietic stem cell transplant (SCT). Among the 65 pts with CR/CRi, 64 (98%) were MRD- within 3 mo. Median DOR by K-M analysis was not reached (Figure): responses were ongoing in 29 pts (max DOR, 29 mo and ongoing); 19 pts relapsed before receiving additional anticancer therapy (13 died subsequently); 8 pts underwent SCT while in remission, 8 received additional anticancer therapy (non-SCT) and 1 discontinued while in remission. The probability of relapse-free survival at 18 mo was 66% (95% CI, 52%-77%). Median OS was not reached; OS probability at 18 mo was 70% (95% CI, 58%-79%). Cytokine release syndrome (CRS) occurred in 77% of pts (grade [G] 3/4; 48%; graded using the Penn scale); 39% of pts received tocilizumab for treatment of CRS with or without other anti-cytokine therapies; 48% of pts required ICU-level care for CRS, with a median ICU stay of 7 d. All cases of CRS were reversible. Most common G 3/4 nonhematologic AEs (>15%) other than CRS were neutropenia with a body temperature >38.3°C (62% within 8 wk of infusion), hypoxia (20%), and hypotension (20%). 13% of pts experienced G 3 neurological events, with no G 4 events or cerebral edema. Based on laboratory results, 43% and 54% of pts had G 3/4 thrombocytopenia and neutropenia not resolved by d 28; the majority of events resolved to G ≤2 by 3 mo. 25 post-infusion deaths were reported: 2 within 30 d (1 disease progression, 1 cerebral hemorrhage); 23 after 30 d of infusion (range, 53-859 d; 18 disease progression, 1 each due to encephalitis, systemic mycosis, VOD [hepatobiliary disorders related to allogeneic-SCT], bacterial lung infection, and an unknown reason after study withdrawal). Tisagenlecleucel expansion in vivo correlated with CRS severity, and persistence of tisagenlecleucel along with B-cell aplasia in peripheral blood was observed for ≥2.5 y in some responding pts. Analysis of B-cell recovery and correlation with relapse will be presented. CONCLUSIONS With longer follow-up, the ELIANA study continues to confirm the efficacy of a single infusion of tisagenlecleucel in pediatric and young adults with ALL without additional therapy. AEs were effectively and reproducibly managed globally by appropriately trained personnel at study sites. The achievement of high overall response rates and deep remissions, in combination with the median duration of response and overall survival not being reached, further corroborate previously reported results. Figure. Figure. Disclosures Grupp: Novartis Pharmaceuticals Corporation: Consultancy, Research Funding; Jazz Pharmaceuticals: Consultancy; Adaptimmune: Consultancy; University of Pennsylvania: Patents & Royalties. Maude:Novartis Pharmaceuticals Corporation: Consultancy, Membership on an entity's Board of Directors or advisory committees. Rives:Shire: Consultancy, Other: Symposia, advisory boards ; Jazz Pharma: Consultancy, Other: Symposia, advisory boards ; Novartis Pharmaceuticals Corporation: Consultancy, Other: Symposia, advisory boards ; Amgen: Consultancy, Other: advisory board . Baruchel:Celgene: Consultancy; Amgen: Consultancy; Roche: Consultancy; Jazz Pharmaceuticals: Consultancy, Honoraria, Other: Travel, accommodations or expenses; Novartis: Membership on an entity's Board of Directors or advisory committees; Shire: Research Funding; Servier: Consultancy. Bittencourt:Novartis Pharmaceuticals Corporation: Consultancy; Jazz Pharmaceuticals: Consultancy, Honoraria. Bader:Riemser: Research Funding; Cellgene: Consultancy; Medac: Patents & Royalties, Research Funding; Neovii: Research Funding; Novartis: Consultancy, Speakers Bureau. Laetsch:Bayer: Consultancy; Pfizer: Equity Ownership; Eli Lilly: Consultancy; Novartis Pharmaceuticals Corporation: Consultancy; Loxo Oncology: Consultancy. Stefanski:Novartis Pharmaceuticals Corporation: Consultancy, Honoraria, Speakers Bureau. Myers:Novartis Pharmaceuticals Corporation: Consultancy, Honoraria, Research Funding, Speakers Bureau. Qayed:Novartis: Consultancy. Pulsipher:CSL Behring: Consultancy; Amgen: Honoraria; Adaptive Biotech: Consultancy, Research Funding; Novartis: Consultancy, Honoraria, Speakers Bureau. Martin:Novartis Pharmaceuticals Corporation: Research Funding; Jazz Pharmaceuticals: Research Funding. Nemecek:Novartis Pharmaceuticals Corporation: Other: advisory boards. Boissel:Servier: Consultancy, Membership on an entity's Board of Directors or advisory committees; Novartis Pharmaceuticals Corporation: Honoraria, Membership on an entity's Board of Directors or advisory committees. Leung:Novartis Pharmaceuticals Corporation: Employment. Eldjerou:Novartis Pharmaceuticals Corporation: Employment. Yi:Novartis Pharmaceuticals Corporation: Employment. Mueller:Novartis Institutes for Biomedical Research: Employment; Novartis Pharmaceuticals Corporation: Equity Ownership, Other: Patent pending. Bleickardt:Novartis Pharmaceuticals Corporation: Employment.
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Shulaeva, Ekaterina A., and Vladimir I. Danilov. "DEVELOPMENT OF AN EDUCATIONAL APPLICATION SIMULATING INDUSTRIAL PRODUCTION PROCESSES IN THE UNITY 3D PERSONAL GAME ENGINE." ELECTRICAL AND DATA PROCESSING FACILITIES AND SYSTEMS 19, no. 2 (2023): 170–80. http://dx.doi.org/10.17122/1999-5458-2023-19-2-170-180.
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Relevance Over time, people's thinking begins to change. They perceive information differently, analyze it differently. As a result, they may have an incorrect or even rare manifestation of the process of any appearance or appearance. Today, written sources, various illustrations, and sometimes video materials are used for use. However, learning means not only the accumulation of knowledge, but also their awareness, embedding them in the mass of the student's already existing experience. If this happens, the requested book will not always be sufficient. When it comes to the fact that a person should not just learn something new, but master, comprehend and apply knowledge in practice, then it is impossible to use it without working out the study of the material on experience. Education based on computer games provides excellent opportunities for learning. Of course, in real life it is possible to simulate this or that situation in the field of application, but this is far from simple and requires quite a lot of time and material costs. In addition, simulating a whole system of situations or even a whole virtual world is a task just for computer games. The development of the educational process in educational institutions requires expectations, and at present there is the possibility of using computer-based learning systems. Training requires the development of high-tech computer applications using modern real-life technologies. As a result, high production processes and an increased understanding of high work skills have been achieved. For the user chose which control. Applications must correctly display the progress of the technological process, its parameters, as well as information in texts or audio format about the process and its elements. Aim of research Development of an educational application in the genre of a simulator that simulates the structure and operation of a neutralization and wastewater treatment plant at manufacturing enterprises in the UNITY 3D PERSONAL development environment. Research methods UNITY 3D PEROSNAL programming environment. Results This article presents the development of an application designed to implement the functions of teaching students and schoolchildren on the basis of Institute of Chemical Technology and Engineering, Ufa State Petroleum Technological University, working out safety precautions by employees of manufacturing enterprises.
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Dobrinsky, J. R., A. M. Paprocki, V. L. Chrostowski, C. M. Penfield, K. R. Rozeboom, and M. E. Wilson. "160 EFFECT OF BSA SOURCES AND TYPES ON IN VITRO-PRODUCED LIVESTOCK EMBRYO DEVELOPMENT." Reproduction, Fertility and Development 18, no. 2 (2006): 188. http://dx.doi.org/10.1071/rdv18n2ab160.
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Bovine serum albumin (BSA) is a macromolecule supplement used in embryo and cell culture media. Other chemicals have been used as macromolecule substitutes in embryo culture with variable effectiveness. There are BSA products available that are defined in their disease status, collection method, and manufacturing process. They are compliant for use in raw form or in culture medium in the USA and EU. It was the purpose of this study to compare the effectiveness of highly defined and internationally compliant BSA with typically used BSA on in vitro-produced pig and cow embryo development. Pig oocyte-cumulus complexes were matured in two stages for 44 h in vitro. Semen from one boar of known high fertility was used across the study to fertilize mature oocytes. After 6-h co-incubation with sperm (50 motile sperm/oocyte), presumptive zygotes were cultured for 120 h in modified NCSU-23 containing 4 mg/mL of one of the following heat-shocked BSA fractions: Sigma A-7906 (control), Minitube Reproductive Biology Grade Fraction-V (RBG-V1, RBG-V2, RBG-V3), or Minitube Reproductive Biology Grade Fatty Acid-Free (RBG-FAF1). Across all treatments, Day 5 morulae were removed from BSA culture and placed into modified NCSU-23 with 10% fetal bovine serum (FBS) (no BSA) and cultured for 48 h. After 168-h total culture, the following blastocyst development was observed: Sigma A-7906, 12.3% (40/324); RBG-V1, 21.1% (36/171); RBG-V2, 19.0% (30/158); RBG-V3, 16.8% (27/161); and RBG-FAF1, 13.4% (21/157). These data show that culture medium supplemented with Minitube Reproductive Biology Grade BSA meets or exceeds (P < 0.05; ANOVA-GLM of SAS; SAS Institute, Inc., Cary, NC, USA) blastocyst development potential when compared to culture medium supplemented with undefined standard BSA preparations, such as Sigma A-7906. In vitro-matured cow cumulus-oocyte complexes were fertilized and cultured in one of two CR-1aa-based media. Oocytes were fertilized in IVF medium containing 6 mg/mL Sigma A-8806 (FAF) or 6 mg/mL Minitube RBG-FAF1. After 24 h in IVF medium, presumptive zygotes from a specific BSA-supplemented medium were cultured for 144 h in CR-1aa supplemented with their respective BSA (8 mg/mL). Day 6 morulae were removed from BSA culture and placed into CR-1aa with 10% FBS (no BSA) and cultured for 48 h. After 192-h total culture, the following blastocyst development from oocytes matured was observed: Sigma A-8806, 21.4% (88/411); RBG-FAF1, 18.9% (70/370). These data show that culture medium supplemented with Minitube Reproductive Biology Grade BSA meets blastocyst development potential (P > 0.05) when compared to culture medium supplemented with undefined standard BSA preparations, such as Sigma A-8806. The inclusion of internationally compliant BSA meets or exceeds blastocyst development rates in comparison to standard BSA preparations in common in vitro embryo production systems for swine and cattle. Although manufacturing differences remain the prominent variant in BSA sources and types, continued monitoring and documentation of BSA preparations tested in livestock in vitro embryo production systems will ensure a safe global supply of BSA products for future culture media production.
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Burkiewicz, Łukasz, and Grażyna Zając. "From the Editors." Perspektywy Kultury 36, no. 1 (March 30, 2022): 11–18. http://dx.doi.org/10.35765/pk.2022.3601.02.
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We begin the new issue of Perspectives on Culture with some very sad news. Dr. Urszula Tes, an outstanding film scholar, affiliated with the Institute of Cultural Studies at Ignatianum University in Krakow for many years, passed away unexpectedly on December 25, 2021. We were not prepared for her passing and we still find it difficult to come to terms with it. Not so long ago we talked with Ula about her idea of creating a permanent film studies section in Perspectives on Culture. Although we were unable to put this idea into motion, we would like to return to it in the near future and dedicate one of the issues of Perspectives on Culture to the memory of Dr. Urszula Tes and film topics so close to her heart.